Antibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- ABIN2846193 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 130-165), (BH3 Domain) antibody
- Antibody type
- Polyclonal
- Description
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- AA 130-165, BH3 Domain
- Antibody clone number
- RB00963
- Vial size
- 80 μL
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Submitted references BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia.
Caspase cleavage of BimEL triggers a positive feedback amplification of apoptotic signaling.
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.
FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines.
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis.
HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim.
Del Gaizo Moore V, Schlis KD, Sallan SE, Armstrong SA, Letai A
Blood 2008 Feb 15;111(4):2300-9
Blood 2008 Feb 15;111(4):2300-9
Caspase cleavage of BimEL triggers a positive feedback amplification of apoptotic signaling.
Chen D, Zhou Q
Proceedings of the National Academy of Sciences of the United States of America 2004 Feb 3;101(5):1235-40
Proceedings of the National Academy of Sciences of the United States of America 2004 Feb 3;101(5):1235-40
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.
Luciano F, Jacquel A, Colosetti P, Herrant M, Cagnol S, Pages G, Auberger P
Oncogene 2003 Oct 2;22(43):6785-93
Oncogene 2003 Oct 2;22(43):6785-93
FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines.
Sunters A, Fernández de Mattos S, Stahl M, Brosens JJ, Zoumpoulidou G, Saunders CA, Coffer PJ, Medema RH, Coombes RC, Lam EW
The Journal of biological chemistry 2003 Dec 12;278(50):49795-805
The Journal of biological chemistry 2003 Dec 12;278(50):49795-805
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis.
Reginato MJ, Mills KR, Paulus JK, Lynch DK, Sgroi DC, Debnath J, Muthuswamy SK, Brugge JS
Nature cell biology 2003 Aug;5(8):733-40
Nature cell biology 2003 Aug;5(8):733-40
HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim.
Chen D, Wang M, Zhou S, Zhou Q
The EMBO journal 2002 Dec 16;21(24):6801-10
The EMBO journal 2002 Dec 16;21(24):6801-10
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC