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ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [2]
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- Product number
- ABIN362371 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (pSer69) antibody
- Antibody type
- Polyclonal
- Antigen
- Peptide sequence around phosphorylation site of pSer69 (P-A-S (p) -P-G) derived from Human BIM. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
- Description
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- pSer69
- Isotype
- IgG
- Vial size
- 50 μL
- Concentration
- 1 mg/mL
- Storage
- Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Submitted references BimEL is an important determinant for induction of anoikis sensitivity by mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitors.
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.
Fukazawa H, Noguchi K, Masumi A, Murakami Y, Uehara Y
Molecular cancer therapeutics 2004 Oct;3(10):1281-8
Molecular cancer therapeutics 2004 Oct;3(10):1281-8
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.
Luciano F, Jacquel A, Colosetti P, Herrant M, Cagnol S, Pages G, Auberger P
Oncogene 2003 Oct 2;22(43):6785-93
Oncogene 2003 Oct 2;22(43):6785-93
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