22037-1-AP

antibody from Proteintech Group

Targeting: BCL2L11 BIM, BimEL, BimL, BimS, BOD

Provider product page for 22037-1-AP

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [33]
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Product number: 22037-1-AP - Provider product page
Provider: Proteintech Group
Product name: Bim antibody
Antibody type: Polyclonal
Description: Bim antibody (Cat. #22037-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

BCL2L11 protein structure - 22037-1-AP shown in red.

Submitted references FBXO3-mediated DUSP9 ubiquitination promotes leukemia stem cell maintenance and tyrosine kinase inhibitor resistance in chronic myeloid leukemia.

Li X, Zuo S, Zhang Y, Liu Z, Shen N, Ma Q, Sun M, Zhang B, Li M, Huang H, Gao M, Huang Z, Zhao H, Chen Y, Gao F, Fan W, Zhang Z, Hu Y, An Y, Li S, Liu M, Liu Y, Liu Y, Li C, Zhang Y, Li Y, Cao W, Wang F, Song Y, Xu L, Bian Z, Li W
Cell reports. Medicine 2026 Mar 17;7(3):102686

TRV130 inhibits colon cancer progression via suppressing the Hedgehog signaling pathway: in vitro and in vivo evidence.

Zhuang Y, Jiang C, Guo Y, Sun J
Hereditas 2026 Jan 19;163(1):26

Ailanthone induces apoptosis in U-2OS cells through the endoplasmic reticulum stress.

Zhang Y, Wu T, Li C, Luo N, Wang J, Li J, Tian M, Liu L, Li R, Zhang J
Frontiers in immunology 2025;16:1633643

TRIM24 promotes T-cell lymphoma development and glucocorticoid resistance via FUS-mediated phase separation of the glucocorticoid receptor.

Wang C, Zhong Y, Xu S, Cai W, Zhao J, Mao J, Jin H, Ouyang C, Shi Y, Chan WC, Huang W, Zhang J, Gu Y
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 Sep;82:101270

Chrysin inhibits PEDV replication by antagonizing apoptosis via the ROS/JNK/p53 axis.

Zhi Y, Ren Y, Xia X, Tian Q, Meng Y, Tao S
Microbial pathogenesis 2025 Nov;208:107957

EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib-Resistant Lung Cancer Therapy.

Wang D, Liu Y, Chen Y, Dai C, Hu W, Han J, Li Z, Yin F, Zhang Y, Shi C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e10197

Glutamine transporter inhibitor enhances the sensitivity of NSCLC to trametinib through GSDME-dependent pyroptosis.

Liu Q, Hu J, Li X, Gao H, Kong D, Jin M
Biochemical pharmacology 2025 Mar;233:116796

FOXK1 promotes hormonally responsive breast carcinogenesis by suppressing apoptosis.

Zhao M, Ma T, Zhang Z, Wang Y, Wang X, Wang W, Chen X, Gao R, Shan L
Animal models and experimental medicine 2025 Apr;8(4):638-648

Selective Organ-Targeting Hafnium Oxide Nanoparticles with Multienzyme-Mimetic Activities Attenuate Radiation-Induced Tissue Damage.

Liu D, Cao F, Xu Z, Zhao C, Liu Z, Pang J, Liu ZX, Moghiseh M, Butler A, Liang S, Fan W, Yang J
Advanced materials (Deerfield Beach, Fla.) 2024 May;36(19):e2308098

N6-Methyladenosine Modification of lncCCKAR-5 Regulates Autophagy in Human Umbilical Cord Mesenchymal Stem Cells by Destabilizing LMNA and Inhibits Diabetic Wound Healing.

Wang J, Wang X, Chen F, Ning Q, Liu Y, Zhu Y, Wei W, Leng M, Wang Z, Jin P, Li Q
The Journal of investigative dermatology 2024 May;144(5):1148-1160.e15

In silico and in vitro analyses of a novel FoxO1 agonist reducing Aβ levels via downregulation of BACE1.

Lv MT, Wang HC, Meng XW, Shi YT, Zhang YM, Shan LL, Shi RL, Ni TJ, Duan YC, Yang ZJ, Zhang W
CNS neuroscience & therapeutics 2024 Mar;30(3):e14140

Cepharanthine sensitizes gastric cancer cells to chemotherapy by targeting TRIB3-FOXO3-FOXM1 axis to inhibit autophagy.

Lu YY, Fang YY, Wang SS, Guo J, Song JL, Zhu L, Lin ZK, Wang R, Zhang SY, Qiu WS, Qi WW
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156161

Luteolin inhibits triple-negative breast cancer by inducing apoptosis and autophagy through SGK1-FOXO3a-BNIP3 signaling.

Wu L, Lin Y, Gao S, Wang Y, Pan H, Wang Z, Pozzolini M, Yang F, Zhang H, Yang Y, Xiao L, Xu Y
Frontiers in pharmacology 2023;14:1200843

High expression of peroxisomal D-bifunctional protein in cytosol regulates apoptosis and energy metabolism of hepatocellular carcinoma cells via PI3K/AKT pathway.

Zhang N, Wang YQ, Sun C, Shi Y, Hou LG, Yao M, Hu M, Wang XM, Ma PP, Li WJ, Jiang LL
American journal of cancer research 2023;13(5):1884-1903

Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.

Zhang X, Dong Z, Yang Y, Liu C, Li J, Sun W, Zhu Y, Shen Y, Wang Z, Lü M, Cui H
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16016-16031

20S-Protopanaxatriol improves cognitive function of Alzheimer's disease by promoting endogenous neurogenesis.

Zhang Q, Yang X, Liu J, Song J, Zhang S, Chen L, Zhang M
Food & function 2023 May 11;14(9):4191-4203

CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway.

Wen C, Li Y, Huang Y, Wang N, He S, Bao M, Zhou H, Wu L
The international journal of biochemistry & cell biology 2023 Jan;154:106344

The miR-27a-3p/FTO axis modifies hypoxia-induced malignant behaviors of glioma cells.

Du P, Meng L, Liao X, Liu Y, Mo X, Gong M, Liao Y
Acta biochimica et biophysica Sinica 2023 Jan 25;55(1):103-116

Combination of a New Oral Demethylating Agent, OR2100, and Venetoclax for Treatment of Acute Myeloid Leukemia.

Kamachi K, Ureshino H, Watanabe T, Yoshida-Sakai N, Fukuda-Kurahashi Y, Kawasoe K, Hoshiko T, Yamamoto Y, Kurahashi Y, Kimura S
Cancer research communications 2023 Feb;3(2):297-308

Circular RNA ARHGAP5 inhibits cisplatin resistance in cervical squamous cell carcinoma by interacting with AUF1.

Deng S, Qian L, Liu L, Liu H, Xu Z, Liu Y, Wang Y, Chen L, Zhou Y
Cancer science 2023 Apr;114(4):1582-1595

Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.

Jiang B, Zhang J, Zhao G, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, Wu C, Yao L, Liu Q, Chen X, Cao Y, Zheng Y, Zhang C, Han A, Lin D, Li Q
Molecular cell 2022 May 19;82(10):1821-1835.e6

Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.

Kang H, Dong Y, Peng R, Liu H, Guo Q, Song K, Zhu M, Yu K, Wu W, Li F
Biochemical pharmacology 2022 Mar;197:114932

Box C/D snoRNA SNORD89 influences the occurrence and development of endometrial cancer through 2'-O-methylation modification of Bim.

Bao HJ, Chen X, Liu X, Wu W, Li QH, Xian JY, Zhao Y, Chen S
Cell death discovery 2022 Jul 5;8(1):309

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Aging 2022 Jan 7;14(1):410-429

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Jie W, Rui-Fen Z, Zhong-Xiang H, Yan W, Wei-Na L, Yong-Ping M, Jing S, Jing-Yi C, Wan-Hong L, Xiao-Hua H, Zhi L, Yan S
Virulence 2022 Dec;13(1):342-354

GABA regulates IL-1β production in macrophages.

Fu J, Han Z, Wu Z, Xia Y, Yang G, Yin Y, Ren W
Cell reports 2022 Dec 6;41(10):111770

The microRNA-10b-Bim axis promotes cancer progression through activating autophagy in oral squamous cell carcinoma.

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Sertad1 Induces Neurological Injury after Ischemic Stroke via the CDK4/p-Rb Pathway.

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One-Two Punch Therapy for the Treatment of T-Cell Malignancies Involving p53-Dependent Cellular Senescence.

Qing Y, Li H, Zhao Y, Hu P, Wang X, Yu X, Zhu M, Wang H, Wang Z, Guo Q, Hui H
Oxidative medicine and cellular longevity 2021;2021:5529518

HES5-mediated repression of LIGHT transcription may contribute to apoptosis in hepatocytes.

Miao X, Guo Y, Zeng S, Liu X, Teng X, Li L, Hong W
Cell death discovery 2021 Oct 23;7(1):308

Inhibition of Bcl-2 and Bcl-xL overcomes the resistance to the third-generation EGFR tyrosine kinase inhibitor osimertinib in non-small cell lung cancer.

Lu Y, Bian D, Zhang X, Zhang H, Zhu Z
Molecular medicine reports 2021 Jan;23(1)

Knockdown of METTL14 inhibits the growth and invasion of cervical cancer.

Geng F, Fan MJ, Li J, Liang SM, Li CY, Li N
Translational cancer research 2019 Oct;8(6):2307-2315

Inhibition of FOXO1 by small interfering RNA enhances proliferation and inhibits apoptosis of papillary thyroid carcinoma cells via Akt/FOXO1/Bim pathway.

Song HM, Song JL, Li DF, Hua KY, Zhao BK, Fang L
OncoTargets and therapy 2015;8:3565-73

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