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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [88]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Other assay [6]
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- Product number
- MA5-15739-D488 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- beta Actin Loading Control Monoclonal Antibody (BA3R), DyLight™ 488
- Antibody type
- Monoclonal
- Antigen
- Synthetic peptide
- Description
- MA5-15739-D488 detects beta actin from human, mouse, rat, rabbit, and chicken samples. MA5-15739-D488 has been successfully used in immunofluorescence. DyLight 488 has an excitation/emission of 493/518 nm. For visualization of actin filaments by immunofluorescence, fixation and permeabilization with methanol is required.
- Reactivity
- Human, Mouse, Rat, Chicken/Avian, Rabbit
- Host
- Mouse
- Conjugate
- Green dye
- Isotype
- IgG
- Antibody clone number
- BA3R
- Vial size
- 50 µL
- Concentration
- 1 mg/mL
- Storage
- 4° C
Submitted references CLEC14A deficiency exacerbates neuronal loss by increasing blood-brain barrier permeability and inflammation.
Estradiol signaling mediates gender difference in visceral adiposity via autophagy.
NF-κB and IRF1 Induce Endogenous Retrovirus K Expression via Interferon-Stimulated Response Elements in Its 5' Long Terminal Repeat.
A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs.
Papillomavirus E6 PDZ interactions can be replaced by repression of p53 to promote episomal human papillomavirus genome maintenance.
Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer.
Elevated suppressor of cytokine signaling-1 (SOCS-1): a mechanism for dysregulated osteoclastogenesis in HIV transgenic rats.
Control of glutamine metabolism by the tumor suppressor Rb.
Caveolin-1 associated adenovirus entry into human corneal cells.
Programmed cell death is impaired in the developing brain of FMR1 mutants.
Modulation of vascular cell function by bim expression.
Amelioration of carbon tetrachloride-induced cirrhosis and portal hypertension in rat using adenoviral gene transfer of Akt.
Up-regulation of vitamin B1 homeostasis genes in breast cancer.
TNFα-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation.
The aryl hydrocarbon receptor and glucocorticoid receptor interact to activate human metallothionein 2A.
Functional characterisation of p53 mutants identified in breast cancers with suboptimal responses to anthracyclines or mitomycin.
Dynamic mast cell-stromal cell interactions promote growth of pancreatic cancer.
The promotion of functional recovery and nerve regeneration after spinal cord injury by lentiviral vectors encoding Lingo-1 shRNA delivered by Pluronic F-127.
XRN4 and LARP1 are required for a heat-triggered mRNA decay pathway involved in plant acclimation and survival during thermal stress.
Cyp1B1 expression promotes angiogenesis by suppressing NF-κB activity.
GroEL1, from Chlamydia pneumoniae, induces vascular adhesion molecule 1 expression by p37(AUF1) in endothelial cells and hypercholesterolemic rabbit.
Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice.
Pentamidine sensitizes chronic myelogenous leukemia K562 cells to TRAIL-induced apoptosis.
Acute lung inflammatory response and injury after hemorrhagic shock are more severe in postpartum rabbits.
Down-regulation of the PI3K/Akt signaling pathway and induction of apoptosis in CA46 Burkitt lymphoma cells by baicalin.
Downregulation of keratins 8, 18 and 19 influences invasiveness of human cultured squamous cell carcinoma and adenocarcinoma cells.
Androgens inhibit tumor necrosis factor-α-induced cell adhesion and promote tube formation of human coronary artery endothelial cells.
Skeletal muscle protein tyrosine phosphatase 1B regulates insulin sensitivity in African Americans.
Deletion of tuberous sclerosis 1 in somatic cells of the murine reproductive tract causes female infertility.
Hsp40 regulates the amount of keratin proteins via ubiquitin-proteasome pathway in cultured human cells.
Quantitative proteomic analysis reveals protein expression changes in the murine neuronal secretome during apoptosis.
Cholesterol-lowering drugs inhibit lectin-like oxidized low-density lipoprotein-1 receptor function by membrane raft disruption.
Tripchlorolide induces cell death in lung cancer cells by autophagy.
Co-expression of laminin β3 and γ2 chains and epigenetic inactivation of laminin α3 chain in gastric cancer.
Phosphorylated Grb14 is an endogenous inhibitor of retinal protein tyrosine phosphatase 1B, and light-dependent activation of Src phosphorylates Grb14.
Catecholaminergic-induced arrhythmias in failing cardiomyocytes associated with human HRCS96A variant overexpression.
The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior.
NCX is an important determinant for premature ventricular activity in a drug-induced model of Andersen-Tawil syndrome.
Lipid metabolism and peroxisome proliferator-activated receptor signaling pathways participate in late-phase liver regeneration.
Severe early-onset preeclampsia is not associated with a change in placental catechol O-methyltransferase (COMT) expression.
Deletion of the p85alpha regulatory subunit of phosphoinositide 3-kinase in cone photoreceptor cells results in cone photoreceptor degeneration.
An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skeletal muscle in KK-A(y) mice.
Targeted inhibition of multiple receptor tyrosine kinases in mesothelioma.
Targeted inhibition of multiple receptor tyrosine kinases in mesothelioma.
Targeting prostate cancer angiogenesis through metastasis-associated protein 1 (MTA1).
Phosphoinositide 3-kinase signaling in retinal rod photoreceptors.
Modulation of interleukin-1β-induced inflammatory responses by a synthetic cationic innate defence regulator peptide, IDR-1002, in synovial fibroblasts.
Transient receptor potential A1 and cannabinoid receptor activity in human normal and hyperplastic prostate: relation to nerves and interstitial cells.
Enhanced retinal insulin receptor-activated neuroprotective survival signal in mice lacking the protein-tyrosine phosphatase-1B gene.
Involvement of the MEKK1 signaling pathway in the regulation of epicardial cell behavior by hyaluronan.
Overexpression of miR-152 leads to reduced expression of human leukocyte antigen-G and increased natural killer cell mediated cytolysis in JEG-3 cells.
Isoniazid-induced apoptosis in HepG2 cells: generation of oxidative stress and Bcl-2 down-regulation.
A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation.
Hypermethylation of HLA class I gene is associated with HLA class I down-regulation in human gastric cancer.
Aspirin inhibits proliferation of gemcitabine-resistant human pancreatic cancer cells and augments gemcitabine-induced cytotoxicity.
Anti-angiogenic activity of triptolide in anaplastic thyroid carcinoma is mediated by targeting vascular endothelial and tumor cells.
Opposing effects of two tissue transglutaminase protein isoforms in neuroblastoma cell differentiation.
Polycomb complexes act redundantly to repress genomic repeats and genes.
Androgens stimulate telomerase expression, activity and phosphorylation in ovarian adenocarcinoma cells.
TGFβ2-mediated production of hyaluronan is important for the induction of epicardial cell differentiation and invasion.
Rimonabant is a dual inhibitor of acyl CoA:cholesterol acyltransferases 1 and 2.
Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence.
Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NuRD complex.
Th17: a new participant in gut dysfunction in mice infected with Trichinella spiralis.
Homologous recombination but not nucleotide excision repair plays a pivotal role in tolerance of DNA-protein cross-links in mammalian cells.
Basal and oxidative stress-induced expression of metallothionein is decreased in ascending aortic aneurysms of bicuspid aortic valve patients.
JNK and p38 were involved in hypoxia and reoxygenation-induced apoptosis of cultured rat cerebellar granule neurons.
Induction of ERBB2 nuclear transport after radiation in breast cancer cells.
IFATS collection: Adipose stromal cells adopt a proangiogenic phenotype under the influence of hypoxia.
Th17 cells influence intestinal muscle contraction during Trichinella spiralis infection.
Size-dependent regulation of Snail2 by hyaluronan: its role in cellular invasion.
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues.
A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factor-kappa B pathway.
Distribution and function of cannabinoid receptors 1 and 2 in the rat, monkey and human bladder.
Transcription factor Sp1 plays an important role in the regulation of copper homeostasis in mammalian cells.
Elevated glutathione levels confer cellular sensitization to cisplatin toxicity by up-regulation of copper transporter hCtr1.
Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis.
SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages.
Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans.
Regulation of sarco/endoplasmic and plasma membrane calcium ATPase gene expression by calcium in cultured human lens epithelial cells.
Activation of PI3-K/Akt pathway for thermal preconditioning to protect cultured cerebellar granule neurons against low potassium-induced apoptosis.
Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells.
Mouse opsin promoter-directed Cre recombinase expression in transgenic mice.
Bacterial redox protein azurin induce apoptosis in human osteosarcoma U2OS cells.
Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation.
Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase.
Protection against oxidized low-density lipoprotein-induced vascular endothelial cell death by integrin-linked kinase.
Protection against oxidized low-density lipoprotein-induced vascular endothelial cell death by integrin-linked kinase.
Kim Y, Lee S, Zhang H, Lee S, Kim H, Kim Y, Won MH, Kim YM, Kwon YG
Journal of neuroinflammation 2020 Feb 4;17(1):48
Journal of neuroinflammation 2020 Feb 4;17(1):48
Estradiol signaling mediates gender difference in visceral adiposity via autophagy.
Tao Z, Zheng LD, Smith C, Luo J, Robinson A, Almeida FA, Wang Z, Olumi AF, Liu D, Cheng Z
Cell death & disease 2018 Feb 22;9(3):309
Cell death & disease 2018 Feb 22;9(3):309
NF-κB and IRF1 Induce Endogenous Retrovirus K Expression via Interferon-Stimulated Response Elements in Its 5' Long Terminal Repeat.
Manghera M, Ferguson-Parry J, Lin R, Douville RN
Journal of virology 2016 Oct 15;90(20):9338-49
Journal of virology 2016 Oct 15;90(20):9338-49
A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs.
Choi J, Lee S, Mallard W, Clement K, Tagliazucchi GM, Lim H, Choi IY, Ferrari F, Tsankov AM, Pop R, Lee G, Rinn JL, Meissner A, Park PJ, Hochedlinger K
Nature biotechnology 2015 Nov;33(11):1173-81
Nature biotechnology 2015 Nov;33(11):1173-81
Papillomavirus E6 PDZ interactions can be replaced by repression of p53 to promote episomal human papillomavirus genome maintenance.
Brimer N, Vande Pol SB
Journal of virology 2014 Mar;88(5):3027-30
Journal of virology 2014 Mar;88(5):3027-30
Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer.
Tanwar PS, Mohapatra G, Chiang S, Engler DA, Zhang L, Kaneko-Tarui T, Ohguchi Y, Birrer MJ, Teixeira JM
Carcinogenesis 2014 Mar;35(3):546-53
Carcinogenesis 2014 Mar;35(3):546-53
Elevated suppressor of cytokine signaling-1 (SOCS-1): a mechanism for dysregulated osteoclastogenesis in HIV transgenic rats.
Lafferty MK, Fantry L, Bryant J, Jones O, Hammoud D, Weitzmann MN, Lewis GK, Garzino-Demo A, Reid W
Pathogens and disease 2014 Jun;71(1):81-9
Pathogens and disease 2014 Jun;71(1):81-9
Control of glutamine metabolism by the tumor suppressor Rb.
Reynolds MR, Lane AN, Robertson B, Kemp S, Liu Y, Hill BG, Dean DC, Clem BF
Oncogene 2014 Jan 30;33(5):556-66
Oncogene 2014 Jan 30;33(5):556-66
Caveolin-1 associated adenovirus entry into human corneal cells.
Yousuf MA, Zhou X, Mukherjee S, Chintakuntlawar AV, Lee JY, Ramke M, Chodosh J, Rajaiya J
PloS one 2013;8(10):e77462
PloS one 2013;8(10):e77462
Programmed cell death is impaired in the developing brain of FMR1 mutants.
Cheng Y, Corbin JG, Levy RJ
Developmental neuroscience 2013;35(4):347-58
Developmental neuroscience 2013;35(4):347-58
Modulation of vascular cell function by bim expression.
Morrison ME, Palenski TL, Jamali N, Sheibani N, Sorenson CM
International journal of cell biology 2013;2013:297537
International journal of cell biology 2013;2013:297537
Amelioration of carbon tetrachloride-induced cirrhosis and portal hypertension in rat using adenoviral gene transfer of Akt.
Deng G, Huang XJ, Luo HW, Huang FZ, Liu XY, Wang YH
World journal of gastroenterology 2013;19(43):7778-87
World journal of gastroenterology 2013;19(43):7778-87
Up-regulation of vitamin B1 homeostasis genes in breast cancer.
Zastre JA, Hanberry BS, Sweet RL, McGinnis AC, Venuti KR, Bartlett MG, Govindarajan R
The Journal of nutritional biochemistry 2013 Sep;24(9):1616-24
The Journal of nutritional biochemistry 2013 Sep;24(9):1616-24
TNFα-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation.
Huai J, Vögtle FN, Jöckel L, Li Y, Kiefer T, Ricci JE, Borner C
Journal of cell science 2013 Sep 1;126(Pt 17):4015-25
Journal of cell science 2013 Sep 1;126(Pt 17):4015-25
The aryl hydrocarbon receptor and glucocorticoid receptor interact to activate human metallothionein 2A.
Sato S, Shirakawa H, Tomita S, Tohkin M, Gonzalez FJ, Komai M
Toxicology and applied pharmacology 2013 Nov 15;273(1):90-9
Toxicology and applied pharmacology 2013 Nov 15;273(1):90-9
Functional characterisation of p53 mutants identified in breast cancers with suboptimal responses to anthracyclines or mitomycin.
Berge EO, Huun J, Lillehaug JR, Lønning PE, Knappskog S
Biochimica et biophysica acta 2013 Mar;1830(3):2790-7
Biochimica et biophysica acta 2013 Mar;1830(3):2790-7
Dynamic mast cell-stromal cell interactions promote growth of pancreatic cancer.
Ma Y, Hwang RF, Logsdon CD, Ullrich SE
Cancer research 2013 Jul 1;73(13):3927-37
Cancer research 2013 Jul 1;73(13):3927-37
The promotion of functional recovery and nerve regeneration after spinal cord injury by lentiviral vectors encoding Lingo-1 shRNA delivered by Pluronic F-127.
Wu HF, Cen JS, Zhong Q, Chen L, Wang J, Deng DY, Wan Y
Biomaterials 2013 Feb;34(6):1686-700
Biomaterials 2013 Feb;34(6):1686-700
XRN4 and LARP1 are required for a heat-triggered mRNA decay pathway involved in plant acclimation and survival during thermal stress.
Merret R, Descombin J, Juan YT, Favory JJ, Carpentier MC, Chaparro C, Charng YY, Deragon JM, Bousquet-Antonelli C
Cell reports 2013 Dec 12;5(5):1279-93
Cell reports 2013 Dec 12;5(5):1279-93
Cyp1B1 expression promotes angiogenesis by suppressing NF-κB activity.
Palenski TL, Gurel Z, Sorenson CM, Hankenson KD, Sheibani N
American journal of physiology. Cell physiology 2013 Dec 1;305(11):C1170-84
American journal of physiology. Cell physiology 2013 Dec 1;305(11):C1170-84
GroEL1, from Chlamydia pneumoniae, induces vascular adhesion molecule 1 expression by p37(AUF1) in endothelial cells and hypercholesterolemic rabbit.
Huang CY, Shih CM, Tsao NW, Chen YH, Li CY, Chang YJ, Chang NC, Ou KL, Lin CY, Lin YW, Nien CH, Lin FY
PloS one 2012;7(8):e42808
PloS one 2012;7(8):e42808
Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice.
Wang ZQ, Yu Y, Zhang XH, Floyd ZE, Boudreau A, Lian K, Cefalu WT
International journal of nanomedicine 2012;7:2999-3012
International journal of nanomedicine 2012;7:2999-3012
Pentamidine sensitizes chronic myelogenous leukemia K562 cells to TRAIL-induced apoptosis.
Qiu G, Jiang J, Liu XS
Leukemia research 2012 Nov;36(11):1417-21
Leukemia research 2012 Nov;36(11):1417-21
Acute lung inflammatory response and injury after hemorrhagic shock are more severe in postpartum rabbits.
Sheng C, Yu YH, Zhao KS, Huang LP, Lodato RF, Wang ZJ, Wang CH, Wang SH, Zha DS
Critical care medicine 2012 May;40(5):1570-7
Critical care medicine 2012 May;40(5):1570-7
Down-regulation of the PI3K/Akt signaling pathway and induction of apoptosis in CA46 Burkitt lymphoma cells by baicalin.
Huang Y, Hu J, Zheng J, Li J, Wei T, Zheng Z, Chen Y
Journal of experimental & clinical cancer research : CR 2012 May 20;31(1):48
Journal of experimental & clinical cancer research : CR 2012 May 20;31(1):48
Downregulation of keratins 8, 18 and 19 influences invasiveness of human cultured squamous cell carcinoma and adenocarcinoma cells.
Uchiumi A, Yamashita M, Katagata Y
Experimental and therapeutic medicine 2012 Mar;3(3):443-448
Experimental and therapeutic medicine 2012 Mar;3(3):443-448
Androgens inhibit tumor necrosis factor-α-induced cell adhesion and promote tube formation of human coronary artery endothelial cells.
Liao CH, Lin FY, Wu YN, Chiang HS
Steroids 2012 Jun;77(7):756-64
Steroids 2012 Jun;77(7):756-64
Skeletal muscle protein tyrosine phosphatase 1B regulates insulin sensitivity in African Americans.
Stull AJ, Wang ZQ, Zhang XH, Yu Y, Johnson WD, Cefalu WT
Diabetes 2012 Jun;61(6):1415-22
Diabetes 2012 Jun;61(6):1415-22
Deletion of tuberous sclerosis 1 in somatic cells of the murine reproductive tract causes female infertility.
Tanaka Y, Park JH, Tanwar PS, Kaneko-Tarui T, Mittal S, Lee HJ, Teixeira JM
Endocrinology 2012 Jan;153(1):404-16
Endocrinology 2012 Jan;153(1):404-16
Hsp40 regulates the amount of keratin proteins via ubiquitin-proteasome pathway in cultured human cells.
Yamazaki S, Uchiumi A, Katagata Y
International journal of molecular medicine 2012 Feb;29(2):165-8
International journal of molecular medicine 2012 Feb;29(2):165-8
Quantitative proteomic analysis reveals protein expression changes in the murine neuronal secretome during apoptosis.
Thouvenot E, Urbach S, Vigy O, Séveno M, Galéotti N, Nguyen G, Bockaert J, Marin P
Journal of proteomics 2012 Dec 21;77:394-405
Journal of proteomics 2012 Dec 21;77:394-405
Cholesterol-lowering drugs inhibit lectin-like oxidized low-density lipoprotein-1 receptor function by membrane raft disruption.
Matarazzo S, Quitadamo MC, Mango R, Ciccone S, Novelli G, Biocca S
Molecular pharmacology 2012 Aug;82(2):246-54
Molecular pharmacology 2012 Aug;82(2):246-54
Tripchlorolide induces cell death in lung cancer cells by autophagy.
Chen L, Liu Q, Huang Z, Wu F, Li Z, Chen X, Lin T
International journal of oncology 2012 Apr;40(4):1066-70
International journal of oncology 2012 Apr;40(4):1066-70
Co-expression of laminin β3 and γ2 chains and epigenetic inactivation of laminin α3 chain in gastric cancer.
Ii M, Yamamoto H, Taniguchi H, Adachi Y, Nakazawa M, Ohashi H, Tanuma T, Sukawa Y, Suzuki H, Sasaki S, Imai K, Shinomura Y
International journal of oncology 2011 Sep;39(3):593-9
International journal of oncology 2011 Sep;39(3):593-9
Phosphorylated Grb14 is an endogenous inhibitor of retinal protein tyrosine phosphatase 1B, and light-dependent activation of Src phosphorylates Grb14.
Basavarajappa DK, Gupta VK, Dighe R, Rajala A, Rajala RV
Molecular and cellular biology 2011 Oct;31(19):3975-87
Molecular and cellular biology 2011 Oct;31(19):3975-87
Catecholaminergic-induced arrhythmias in failing cardiomyocytes associated with human HRCS96A variant overexpression.
Han P, Cai W, Wang Y, Lam CK, Arvanitis DA, Singh VP, Chen S, Zhang H, Zhang R, Cheng H, Kranias EG
American journal of physiology. Heart and circulatory physiology 2011 Oct;301(4):H1588-95
American journal of physiology. Heart and circulatory physiology 2011 Oct;301(4):H1588-95
The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior.
Sánchez NS, Hill CR, Love JD, Soslow JH, Craig E, Austin AF, Brown CB, Czirok A, Camenisch TD, Barnett JV
Developmental biology 2011 Oct 15;358(2):331-43
Developmental biology 2011 Oct 15;358(2):331-43
NCX is an important determinant for premature ventricular activity in a drug-induced model of Andersen-Tawil syndrome.
Radwański PB, Poelzing S
Cardiovascular research 2011 Oct 1;92(1):57-66
Cardiovascular research 2011 Oct 1;92(1):57-66
Lipid metabolism and peroxisome proliferator-activated receptor signaling pathways participate in late-phase liver regeneration.
Yuan X, Yan S, Zhao J, Shi D, Yuan B, Dai W, Jiao B, Zhang W, Miao M
Journal of proteome research 2011 Mar 4;10(3):1179-90
Journal of proteome research 2011 Mar 4;10(3):1179-90
Severe early-onset preeclampsia is not associated with a change in placental catechol O-methyltransferase (COMT) expression.
Palmer K, Saglam B, Whitehead C, Stock O, Lappas M, Tong S
The American journal of pathology 2011 Jun;178(6):2484-8
The American journal of pathology 2011 Jun;178(6):2484-8
Deletion of the p85alpha regulatory subunit of phosphoinositide 3-kinase in cone photoreceptor cells results in cone photoreceptor degeneration.
Ivanovic I, Anderson RE, Le YZ, Fliesler SJ, Sherry DM, Rajala RV
Investigative ophthalmology & visual science 2011 Jun 1;52(6):3775-83
Investigative ophthalmology & visual science 2011 Jun 1;52(6):3775-83
An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skeletal muscle in KK-A(y) mice.
Wang ZQ, Ribnicky D, Zhang XH, Zuberi A, Raskin I, Yu Y, Cefalu WT
The Journal of nutritional biochemistry 2011 Jan;22(1):71-8
The Journal of nutritional biochemistry 2011 Jan;22(1):71-8
Targeted inhibition of multiple receptor tyrosine kinases in mesothelioma.
Ou WB, Hubert C, Corson JM, Bueno R, Flynn DL, Sugarbaker DJ, Fletcher JA
Neoplasia (New York, N.Y.) 2011 Jan;13(1):12-22
Neoplasia (New York, N.Y.) 2011 Jan;13(1):12-22
Targeted inhibition of multiple receptor tyrosine kinases in mesothelioma.
Ou WB, Hubert C, Corson JM, Bueno R, Flynn DL, Sugarbaker DJ, Fletcher JA
Neoplasia (New York, N.Y.) 2011 Jan;13(1):12-22
Neoplasia (New York, N.Y.) 2011 Jan;13(1):12-22
Targeting prostate cancer angiogenesis through metastasis-associated protein 1 (MTA1).
Kai L, Wang J, Ivanovic M, Chung YT, Laskin WB, Schulze-Hoepfner F, Mirochnik Y, Satcher RL Jr, Levenson AS
The Prostate 2011 Feb 15;71(3):268-80
The Prostate 2011 Feb 15;71(3):268-80
Phosphoinositide 3-kinase signaling in retinal rod photoreceptors.
Ivanovic I, Allen DT, Dighe R, Le YZ, Anderson RE, Rajala RV
Investigative ophthalmology & visual science 2011 Aug 11;52(9):6355-62
Investigative ophthalmology & visual science 2011 Aug 11;52(9):6355-62
Modulation of interleukin-1β-induced inflammatory responses by a synthetic cationic innate defence regulator peptide, IDR-1002, in synovial fibroblasts.
Turner-Brannen E, Choi KY, Lippert DN, Cortens JP, Hancock RE, El-Gabalawy H, Mookherjee N
Arthritis research & therapy 2011 Aug 11;13(4):R129
Arthritis research & therapy 2011 Aug 11;13(4):R129
Transient receptor potential A1 and cannabinoid receptor activity in human normal and hyperplastic prostate: relation to nerves and interstitial cells.
Gratzke C, Weinhold P, Reich O, Seitz M, Schlenker B, Stief CG, Andersson KE, Hedlund P
European urology 2010 May;57(5):902-10
European urology 2010 May;57(5):902-10
Enhanced retinal insulin receptor-activated neuroprotective survival signal in mice lacking the protein-tyrosine phosphatase-1B gene.
Rajala RV, Tanito M, Neel BG, Rajala A
The Journal of biological chemistry 2010 Mar 19;285(12):8894-904
The Journal of biological chemistry 2010 Mar 19;285(12):8894-904
Involvement of the MEKK1 signaling pathway in the regulation of epicardial cell behavior by hyaluronan.
Craig EA, Parker P, Austin AF, Barnett JV, Camenisch TD
Cellular signalling 2010 Jun;22(6):968-76
Cellular signalling 2010 Jun;22(6):968-76
Overexpression of miR-152 leads to reduced expression of human leukocyte antigen-G and increased natural killer cell mediated cytolysis in JEG-3 cells.
Zhu XM, Han T, Wang XH, Li YH, Yang HG, Luo YN, Yin GW, Yao YQ
American journal of obstetrics and gynecology 2010 Jun;202(6):592.e1-7
American journal of obstetrics and gynecology 2010 Jun;202(6):592.e1-7
Isoniazid-induced apoptosis in HepG2 cells: generation of oxidative stress and Bcl-2 down-regulation.
Bhadauria S, Mishra R, Kanchan R, Tripathi C, Srivastava A, Tiwari A, Sharma S
Toxicology mechanisms and methods 2010 Jun;20(5):242-51
Toxicology mechanisms and methods 2010 Jun;20(5):242-51
A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation.
Hubbard LL, Ballinger MN, Thomas PE, Wilke CA, Standiford TJ, Kobayashi KS, Flavell RA, Moore BB
Journal of immunology (Baltimore, Md. : 1950) 2010 Jun 1;184(11):6299-308
Journal of immunology (Baltimore, Md. : 1950) 2010 Jun 1;184(11):6299-308
Hypermethylation of HLA class I gene is associated with HLA class I down-regulation in human gastric cancer.
Ye Q, Shen Y, Wang X, Yang J, Miao F, Shen C, Zhang J
Tissue antigens 2010 Jan;75(1):30-9
Tissue antigens 2010 Jan;75(1):30-9
Aspirin inhibits proliferation of gemcitabine-resistant human pancreatic cancer cells and augments gemcitabine-induced cytotoxicity.
Ou YQ, Zhu Wb, Li Y, Qiu PX, Huang YJ, Xie J, He SM, Zheng XK, Leng TD, Xu D, Yan GM
Acta pharmacologica Sinica 2010 Jan;31(1):73-80
Acta pharmacologica Sinica 2010 Jan;31(1):73-80
Anti-angiogenic activity of triptolide in anaplastic thyroid carcinoma is mediated by targeting vascular endothelial and tumor cells.
Zhu W, He S, Li Y, Qiu P, Shu M, Ou Y, Zhou Y, Leng T, Xie J, Zheng X, Xu D, Su X, Yan G
Vascular pharmacology 2010 Jan-Feb;52(1-2):46-54
Vascular pharmacology 2010 Jan-Feb;52(1-2):46-54
Opposing effects of two tissue transglutaminase protein isoforms in neuroblastoma cell differentiation.
Tee AEL, Marshall GM, Liu PY, Xu N, Haber M, Norris MD, Iismaa SE, Liu T
The Journal of biological chemistry 2010 Feb 5;285(6):3561-3567
The Journal of biological chemistry 2010 Feb 5;285(6):3561-3567
Polycomb complexes act redundantly to repress genomic repeats and genes.
Leeb M, Pasini D, Novatchkova M, Jaritz M, Helin K, Wutz A
Genes & development 2010 Feb 1;24(3):265-76
Genes & development 2010 Feb 1;24(3):265-76
Androgens stimulate telomerase expression, activity and phosphorylation in ovarian adenocarcinoma cells.
Nourbakhsh M, Golestani A, Zahrai M, Modarressi MH, Malekpour Z, Karami-Tehrani F
Molecular and cellular endocrinology 2010 Dec 15;330(1-2):10-6
Molecular and cellular endocrinology 2010 Dec 15;330(1-2):10-6
TGFβ2-mediated production of hyaluronan is important for the induction of epicardial cell differentiation and invasion.
Craig EA, Austin AF, Vaillancourt RR, Barnett JV, Camenisch TD
Experimental cell research 2010 Dec 10;316(20):3397-405
Experimental cell research 2010 Dec 10;316(20):3397-405
Rimonabant is a dual inhibitor of acyl CoA:cholesterol acyltransferases 1 and 2.
Netherland C, Thewke DP
Biochemical and biophysical research communications 2010 Aug 6;398(4):671-6
Biochemical and biophysical research communications 2010 Aug 6;398(4):671-6
Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence.
Tavana O, Benjamin CL, Puebla-Osorio N, Sang M, Ullrich SE, Ananthaswamy HN, Zhu C
Cell cycle (Georgetown, Tex.) 2010 Aug 15;9(16):3328-36
Cell cycle (Georgetown, Tex.) 2010 Aug 15;9(16):3328-36
Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NuRD complex.
Kai L, Samuel SK, Levenson AS
International journal of cancer 2010 Apr 1;126(7):1538-48
International journal of cancer 2010 Apr 1;126(7):1538-48
Th17: a new participant in gut dysfunction in mice infected with Trichinella spiralis.
Fu Y, Wang W, Tong J, Pan Q, Long Y, Qian W, Hou X
Mediators of inflammation 2009;2009:517052
Mediators of inflammation 2009;2009:517052
Homologous recombination but not nucleotide excision repair plays a pivotal role in tolerance of DNA-protein cross-links in mammalian cells.
Nakano T, Katafuchi A, Matsubara M, Terato H, Tsuboi T, Masuda T, Tatsumoto T, Pack SP, Makino K, Croteau DL, Van Houten B, Iijima K, Tauchi H, Ide H
The Journal of biological chemistry 2009 Oct 2;284(40):27065-76
The Journal of biological chemistry 2009 Oct 2;284(40):27065-76
Basal and oxidative stress-induced expression of metallothionein is decreased in ascending aortic aneurysms of bicuspid aortic valve patients.
Phillippi JA, Klyachko EA, Kenny JP 4th, Eskay MA, Gorman RC, Gleason TG
Circulation 2009 May 12;119(18):2498-506
Circulation 2009 May 12;119(18):2498-506
JNK and p38 were involved in hypoxia and reoxygenation-induced apoptosis of cultured rat cerebellar granule neurons.
Liu AL, Wang XW, Liu AH, Su XW, Jiang WJ, Qiu PX, Yan GM
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 2009 Mar;61(2):137-43
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 2009 Mar;61(2):137-43
Induction of ERBB2 nuclear transport after radiation in breast cancer cells.
Luo B, Yu S, Zhuang L, Xia S, Zhao Z, Rong L
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2009 Jun;29(3):350-3
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2009 Jun;29(3):350-3
IFATS collection: Adipose stromal cells adopt a proangiogenic phenotype under the influence of hypoxia.
Thangarajah H, Vial IN, Chang E, El-Ftesi S, Januszyk M, Chang EI, Paterno J, Neofytou E, Longaker MT, Gurtner GC
Stem cells (Dayton, Ohio) 2009 Jan;27(1):266-74
Stem cells (Dayton, Ohio) 2009 Jan;27(1):266-74
Th17 cells influence intestinal muscle contraction during Trichinella spiralis infection.
Fu Y, Wang W, Tong J, Pan Q, Long Y, Qian W, Hou X
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2009 Aug;29(4):481-5
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2009 Aug;29(4):481-5
Size-dependent regulation of Snail2 by hyaluronan: its role in cellular invasion.
Craig EA, Parker P, Camenisch TD
Glycobiology 2009 Aug;19(8):890-8
Glycobiology 2009 Aug;19(8):890-8
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues.
Thangarajah H, Yao D, Chang EI, Shi Y, Jazayeri L, Vial IN, Galiano RD, Du XL, Grogan R, Galvez MG, Januszyk M, Brownlee M, Gurtner GC
Proceedings of the National Academy of Sciences of the United States of America 2009 Aug 11;106(32):13505-10
Proceedings of the National Academy of Sciences of the United States of America 2009 Aug 11;106(32):13505-10
A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factor-kappa B pathway.
Zhu W, Ou Y, Li Y, Xiao R, Shu M, Zhou Y, Xie J, He S, Qiu P, Yan G
Molecular pharmacology 2009 Apr;75(4):812-9
Molecular pharmacology 2009 Apr;75(4):812-9
Distribution and function of cannabinoid receptors 1 and 2 in the rat, monkey and human bladder.
Gratzke C, Streng T, Park A, Christ G, Stief CG, Hedlund P, Andersson KE
The Journal of urology 2009 Apr;181(4):1939-48
The Journal of urology 2009 Apr;181(4):1939-48
Transcription factor Sp1 plays an important role in the regulation of copper homeostasis in mammalian cells.
Song IS, Chen HH, Aiba I, Hossain A, Liang ZD, Klomp LW, Kuo MT
Molecular pharmacology 2008 Sep;74(3):705-13
Molecular pharmacology 2008 Sep;74(3):705-13
Elevated glutathione levels confer cellular sensitization to cisplatin toxicity by up-regulation of copper transporter hCtr1.
Chen HH, Song IS, Hossain A, Choi MK, Yamane Y, Liang ZD, Lu J, Wu LY, Siddik ZH, Klomp LW, Savaraj N, Kuo MT
Molecular pharmacology 2008 Sep;74(3):697-704
Molecular pharmacology 2008 Sep;74(3):697-704
Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis.
Li Z, Jiang J, Wang Z, Zhang J, Xiao M, Wang C, Lu Y, Qin Z
Cancer research 2008 Nov 1;68(21):8687-94
Cancer research 2008 Nov 1;68(21):8687-94
SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages.
Chiu SY, Asai N, Costantini F, Hsu W
PLoS biology 2008 Dec 16;6(12):e310
PLoS biology 2008 Dec 16;6(12):e310
Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans.
An G, Wei B, Xia B, McDaniel JM, Ju T, Cummings RD, Braun J, Xia L
The Journal of experimental medicine 2007 Jun 11;204(6):1417-29
The Journal of experimental medicine 2007 Jun 11;204(6):1417-29
Regulation of sarco/endoplasmic and plasma membrane calcium ATPase gene expression by calcium in cultured human lens epithelial cells.
Marian MJ, Mukhopadhyay P, Borchman D, Tang D, Paterson CA
Cell calcium 2007 Jan;41(1):87-95
Cell calcium 2007 Jan;41(1):87-95
Activation of PI3-K/Akt pathway for thermal preconditioning to protect cultured cerebellar granule neurons against low potassium-induced apoptosis.
Cao L, Cao DX, Su XW, Chen LJ, Liu AL, Jian WJ, Wu YP, Qiu PX, Yan GM
Acta pharmacologica Sinica 2007 Feb;28(2):173-9
Acta pharmacologica Sinica 2007 Feb;28(2):173-9
Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells.
Thebault S, Flourakis M, Vanoverberghe K, Vandermoere F, Roudbaraki M, Lehen'kyi V, Slomianny C, Beck B, Mariot P, Bonnal JL, Mauroy B, Shuba Y, Capiod T, Skryma R, Prevarskaya N
Cancer research 2006 Feb 15;66(4):2038-47
Cancer research 2006 Feb 15;66(4):2038-47
Mouse opsin promoter-directed Cre recombinase expression in transgenic mice.
Le YZ, Zheng L, Zheng W, Ash JD, Agbaga MP, Zhu M, Anderson RE
Molecular vision 2006 Apr 18;12:389-98
Molecular vision 2006 Apr 18;12:389-98
Bacterial redox protein azurin induce apoptosis in human osteosarcoma U2OS cells.
Yang DS, Miao XD, Ye ZM, Feng J, Xu RZ, Huang X, Ge FF
Pharmacological research 2005 Nov;52(5):413-21
Pharmacological research 2005 Nov;52(5):413-21
Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation.
Ehrhart J, Obregon D, Mori T, Hou H, Sun N, Bai Y, Klein T, Fernandez F, Tan J, Shytle RD
Journal of neuroinflammation 2005 Dec 12;2:29
Journal of neuroinflammation 2005 Dec 12;2:29
Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase.
Zhang X, Li Y, Huang Q, Wang H, Yan B, Dewhirst MW, Li CY
Clinical cancer research : an official journal of the American Association for Cancer Research 2003 Mar;9(3):1155-60
Clinical cancer research : an official journal of the American Association for Cancer Research 2003 Mar;9(3):1155-60
Protection against oxidized low-density lipoprotein-induced vascular endothelial cell death by integrin-linked kinase.
Zhang X, Hu K, Li CY
Circulation 2001 Dec 4;104(23):2762-6
Circulation 2001 Dec 4;104(23):2762-6
Protection against oxidized low-density lipoprotein-induced vascular endothelial cell death by integrin-linked kinase.
Zhang X, Hu K, Li CY
Circulation 2001 Dec 4;104(23):2762-6
Circulation 2001 Dec 4;104(23):2762-6
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- Western Blot was performed using Anti-beta Actin Loading Control Monoclonal Antibody (BA3R), DyLight 488 (Product # MA5-15739-D488) and a ~40 kDa band corresponding to Actin, cytoplasmic 1 was observed across cell lines and tissues tested. Whole cell extracts (30 µg lysate) of HeLa (Lane 1), A549 (Lane 2), A-431 (Lane 3), U-2 OS (Lane 4), Jurkat (Lane 5), PC-12 (Lane 6), NIH/3T3 (Lane 7), Mouse Spleen (Lane 8), Mouse Liver (Lane 9), Rat Spleen (Lane 10), Rat Liver (Lane 11) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). Resolved proteins were then transferred onto a Nitrocellulose membrane (Product # LC2001) by iBlot® 2 Dry Blotting System (Product # IB21001). The Blot was probed with the primary antibody (1:1000 dilution) and detected by fluorescence using the iBright FL 1000 (Product # A32752). Fluorescent detection was performed. doi:10.1038/bcj.2014.18
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- Immunofluorescent analysis of beta-actin (green) in HeLa cells. Cells were fixed with either 4% paraformaldehyde (PFA) for 15 minutes at room temperature followed by permeabilization with 0.5% Triton X-100 in PBS for 15 minutes at room temperature (left panel) or fixed and permeabilized with ice-cold methanol for 10 minutes at room temperature (right panel). Cells were blocked with 0.3% BSA in PBS for 15 minutes, and probed with a DyLight 488-conjugated beta-actin monoclonal antibody (Product # MA5-15739-D488) at a dilution of 1:20 overnight at 4C. Nuclei (blue) were stained with DAPI (Product # 62247). Images were taken on a ToxInsight Instrument at 20X magnification.
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- Figure 3 Differentially expressed genes (DEGs) between isogenic hESC and hiPSC lines (a) Venn diagram showing the number of genes consistently up- or down- regulated in 3 biological replicate hiPSC lines when compared to 3 biological replicate hESC GFP lines from the same genetic background. (FDR
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- Fig. 2 Loss of CLEC14A exacerbated cerebral injury with VEGFR2 activation in MCAO stroke model. a , c Images of whole brains and comparison of Evans blue dye (EB) leakage in brains (P8 and adult) after EB injection (intraperitoneal route) in WT and CLEC14A KO mice ( n = 6, each group). b , d The quantitative analysis of Evans blue (EB) dye extravasation using spectrophotometer, 24 h after intraperitoneal injection of EB dye. e TTC staining of brain slices in the sham, WT, and CLEC14A KO groups 24-h post ischemia-reperfusion. Severe infarction was present in the CLEC14A KO group. Scale bar = 1 mm. f Percentage of infarct volume in the WT and CLEC14A KO groups 24 h after ischemia-reperfusion. g Neurological scores of WT and CLEC14A KO mice were evaluated. h VEGFR2, pVEGFR2 protein expression in ipsilateral brain lysate after ischemia-reperfusion injury. i , j Quantification data of relative pVEGFR2 and VEGFR2 protein expression. n = 6 per group; * P < 0.05, ** P < 0.01, *** P < 0.001. The results are mean values and the error bars represent the mean +- SD
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- Fig. 4 CLEC14A deletion attenuated tight junctional proteins in cerebral ischemic regions. a Immunofluorescence staining for Occludin, Claudin-5, ZO-1, and CD31 with DAPI in the ischemic cortex of WT and CLEC14A KO mice 24 h after ischemia-reperfusion. n = 6 per group. Scale bars: 20 mum. b Quantitative analysis of Occludin/CD31 ratio. c Quantitative analysis of Claudin-5/CD31 ratio. d Quantitative analysis of ZO-1/CD31 ratio. e , f Western blot analysis of tight junctional proteins from ischemic brain and quantitative graph. * P < 0.05, ** P < 0.01, and *** P < 0.001. The results are mean values and the error bars represent the mean +- SD
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