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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [8]
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- Product number
- ABIN117947 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Cullin 1 (CUL1) (C-Term), (AA 742-752) antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide corresponding to amino acids 742-752 of Human Cul1 (C-terminus) coupled to KLH.
- Description
- Delipidation and defibrination.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Antigen sequence
Human Cullin 1 (776 aa 89.6 kDa): 1
msstrsqnph glkqigldqi wddlragiqq v
ytrqsmaks rymelythvy nyctsvhqsn 61
qargagvpps kskkgqtpgg aqfvglelyk rl
keflknyl tnllkdgedl mdesvlkfyt 121
qqwedyrfss kvlngicayl nrhwvrrecd eg
rkgiyeiy slalvtwrdc lfrplnkqvt 181
navlklieke rngetintrl isgvvqsyve lg
lneddafa kgptltvyke sfesqfladt 241
erfytreste flqqnpvtey mkkaearlle eq
rrvqvylh estqdelark ceqvliekhl 301
eifhtefqnl ldadknedlg rmynlvsriq dg
lgelkkll ethihnqgla aiekcgeaal 361
ndpkmyvqtv ldvhkkynal vmsafnndag fv
aaldkacg rfinnnavtk maqssskspe 421
llarycdsll kkssknpeea eledtlnqvm vv
fkyiedkd vfqkfyakml akrlvhqnsa 481
sddaeasmis klkqacgfey tsklqrmfqd ig
vskdlneq fkkhltnsep ldldfsiqvl 541
ssgswpfqqs ctfalpsele rsyqrftafy as
rhsgrklt wlyqlskgel vtncfknryt 601
lqastfqmai llqynteday tvqqltdstq ik
mdilaqvl qillkskllv ledenanvde 661
velkpdtlik lylgyknkkl rvninvpmkt eq
kqeqetth knieedrkll iqaaivrimk 721
mrkvlkhqql lgevltqlss rfkprvpvik kc
idilieke ylervdgekd tysyla- Epitope
- C-Term,AA 742-752
- Vial size
- 0.1 mL
- Concentration
- 85.0 mg/mL (by Refractometry)
- Storage
- Store undiluted at 2-8°C for one month or at -20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references Ubiquitin and its kin: how close are the family ties?
Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha.
Covalent modification of all members of human cullin family proteins by NEDD8.
ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.
Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha.
Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A.
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.
Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins.
Jentsch S, Pyrowolakis G
Trends in cell biology 2000 Aug;10(8):335-42
Trends in cell biology 2000 Aug;10(8):335-42
Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha.
Read MA, Brownell JE, Gladysheva TB, Hottelet M, Parent LA, Coggins MB, Pierce JW, Podust VN, Luo RS, Chau V, Palombella VJ
Molecular and cellular biology 2000 Apr;20(7):2326-33
Molecular and cellular biology 2000 Apr;20(7):2326-33
Covalent modification of all members of human cullin family proteins by NEDD8.
Hori T, Osaka F, Chiba T, Miyamoto C, Okabayashi K, Shimbara N, Kato S, Tanaka K
Oncogene 1999 Nov 18;18(48):6829-34
Oncogene 1999 Nov 18;18(48):6829-34
ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.
Ohta T, Michel JJ, Schottelius AJ, Xiong Y
Molecular cell 1999 Apr;3(4):535-41
Molecular cell 1999 Apr;3(4):535-41
Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha.
Tan P, Fuchs SY, Chen A, Wu K, Gomez C, Ronai Z, Pan ZQ
Molecular cell 1999 Apr;3(4):527-33
Molecular cell 1999 Apr;3(4):527-33
Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A.
Michel JJ, Xiong Y
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998 Jun;9(6):435-49
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998 Jun;9(6):435-49
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.
Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM
Cell 1996 Jun 14;85(6):829-39
Cell 1996 Jun 14;85(6):829-39
Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins.
Mathias N, Johnson SL, Winey M, Adams AE, Goetsch L, Pringle JR, Byers B, Goebl MG
Molecular and cellular biology 1996 Dec;16(12):6634-43
Molecular and cellular biology 1996 Dec;16(12):6634-43
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