Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 10981-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10981-2-AP, RRID:AB_2086422
- Product name
- CUL2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CUL2 antibody (Cat. #10981-2-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A.
A positive feedback loop between miR-574-3p and HIF-1α in promoting angiogenesis under hypoxia.
The N(6)-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.
iASPP is essential for HIF-1α stabilization to promote angiogenesis and glycolysis via attenuating VHL-mediated protein degradation.
CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation.
Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition by targeting ZEB1 for proteasomal degradation in hepatocellular carcinoma.
Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.
A Human Long Non-Coding RNA ALT1 Controls the Cell Cycle of Vascular Endothelial Cells Via ACE2 and Cyclin D1 Pathway.
AMBRA1 interplay with cullin E3 ubiquitin ligases regulates autophagy dynamics.
DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase.
Aberrant expression of microRNAs in gastric cancer and biological significance of miR-574-3p.
Mu M, Zhang Q, Li J, Zhao C, Li X, Chen Z, Sun X, Yu J
Cell death and differentiation 2023 Nov;30(11):2393-2407
Cell death and differentiation 2023 Nov;30(11):2393-2407
A positive feedback loop between miR-574-3p and HIF-1α in promoting angiogenesis under hypoxia.
Zhang R, Miao Z, Liu Y, Zhang X, Yang Q
Microvascular research 2023 Nov;150:104589
Microvascular research 2023 Nov;150:104589
The N(6)-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.
Li B, Zhao R, Qiu W, Pan Z, Zhao S, Qi Y, Qiu J, Zhang S, Guo Q, Fan Y, Xu H, Li M, Li G, Xue H
Theranostics 2022;12(14):6363-6379
Theranostics 2022;12(14):6363-6379
iASPP is essential for HIF-1α stabilization to promote angiogenesis and glycolysis via attenuating VHL-mediated protein degradation.
Zhao D, Zheng S, Wang X, Liu H, Zhao K, Li L, Hu Y
Oncogene 2022 Mar;41(13):1944-1958
Oncogene 2022 Mar;41(13):1944-1958
CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation.
Zhang P, Gao K, Zhang L, Sun H, Zhao X, Liu Y, Lv Z, Shi Q, Chen Y, Jiao D, Li Y, Gu W, Wang C
Cell death and differentiation 2022 Apr;29(4):758-771
Cell death and differentiation 2022 Apr;29(4):758-771
Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition by targeting ZEB1 for proteasomal degradation in hepatocellular carcinoma.
Dong X, Han Y, Zhang E, Wang Y, Zhang P, Wang C, Zhong L, Li Q
Aging 2021 Apr 4;13(7):10603-10618
Aging 2021 Apr 4;13(7):10603-10618
Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.
Nagai T, Mukoyama S, Kagiwada H, Goshima N, Mizuno K
Journal of cell science 2018 Dec 12;131(24)
Journal of cell science 2018 Dec 12;131(24)
A Human Long Non-Coding RNA ALT1 Controls the Cell Cycle of Vascular Endothelial Cells Via ACE2 and Cyclin D1 Pathway.
Li W, Wang R, Ma JY, Wang M, Cui J, Wu WB, Liu RM, Zhang CX, Li W, Wang SM
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(3):1152-1167
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(3):1152-1167
AMBRA1 interplay with cullin E3 ubiquitin ligases regulates autophagy dynamics.
Antonioli M, Albiero F, Nazio F, Vescovo T, Perdomo AB, Corazzari M, Marsella C, Piselli P, Gretzmeier C, Dengjel J, Cecconi F, Piacentini M, Fimia GM
Developmental cell 2014 Dec 22;31(6):734-46
Developmental cell 2014 Dec 22;31(6):734-46
DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase.
Chen H, Ma H, Inuzuka H, Diao J, Lan F, Shi YG, Wei W, Shi Y
Molecular and cellular biology 2013 Mar;33(6):1139-48
Molecular and cellular biology 2013 Mar;33(6):1139-48
Aberrant expression of microRNAs in gastric cancer and biological significance of miR-574-3p.
Su Y, Ni Z, Wang G, Cui J, Wei C, Wang J, Yang Q, Xu Y, Li F
International immunopharmacology 2012 Aug;13(4):468-75
International immunopharmacology 2012 Aug;13(4):468-75
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10981-2-AP(CUL2 antibody) at dilution of 1:100
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using CUL2 antibody 10981-2-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-CUL2 (IP:10981-2-AP, 4ug; Detection:10981-2-AP 1:200) with HeLa cells lysate 2500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 10981-2-AP(CUL2 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue