BS6991

antibody from Bioworld Technology, Inc
Targeting: CUL2
Provider product page for BS6991
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6991 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CUL 2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human CUL 2.
Description
CUL-1 mediated ubiquitination results in the degradation of cell cycle proteins cyclin D, p21 and cyclin E. Another cullin, CUL-3 facilitates the degradation of cyclin E independent of SCF activity, while CUL-2 associates with the tumor suppressing protein VHL and elongin B to form VBC complexes, which structurally resemble the SCF ligase. Proteolysis also occurs by way of CUL-4 associating with Nedd-8, a ubiquitin- like protein, where it too functions as an active component of a multifunctional E3 complex. CUL-5, or vasopressin-activated, calcium-mobilizing protein (VACM-1), is also included in the cullin family as it shares substantial sequence homology with CUL-1.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CUL2 protein structure - BS6991 shown in red.