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- References [19]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11107-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11107-1-AP, RRID:AB_2086429
- Product name
- CUL3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CUL3 antibody (Cat. #11107-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references β-Sitosterol targets ASS1 for Nrf2 ubiquitin-dependent degradation, inducing ROS-mediated apoptosis via the PTEN/PI3K/AKT signaling pathway in ovarian cancer.
Pharmacological inhibition of neddylation impairs long interspersed element 1 retrotransposition.
KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC.
CUL3 induces mitochondrial dysfunction via MRPL12 ubiquitination in renal tubular epithelial cells.
DDRGK1 Enhances Osteosarcoma Chemoresistance via Inhibiting KEAP1-Mediated NRF2 Ubiquitination.
Norcantharidin promotes cancer radiosensitization through Cullin1 neddylation-mediated CDC6 protein degradation.
SQSTM1/ p62 oligomerization contributes to Aβ-induced inhibition of Nrf2 signaling.
Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination.
USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway.
Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition by targeting ZEB1 for proteasomal degradation in hepatocellular carcinoma.
Arsenic trioxide (ATO) induced degradation of Cyclin D1 sensitized PD-1/PD-L1 checkpoint inhibitor in oral and esophageal squamous cell carcinoma.
KLHL18 inhibits the proliferation, migration, and invasion of non-small cell lung cancer by inhibiting PI3K/PD-L1 axis activity.
The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina.
Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.
Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.
l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Increased Expression of Cullin 3 in Nasopharyngeal Carcinoma and Knockdown Inhibits Proliferation and Invasion.
H(2)S regulates endothelial nitric oxide synthase protein stability by promoting microRNA-455-3p expression.
Wang H, Liu J, Zhang Z, Peng J, Wang Z, Yang L, Wang X, Hu S, Hong L
Free radical biology & medicine 2024 Mar;214:137-157
Free radical biology & medicine 2024 Mar;214:137-157
Pharmacological inhibition of neddylation impairs long interspersed element 1 retrotransposition.
Li Y, Shen S, Guo H, Li H, Zhang L, Zhang B, Yu XF, Wei W
Cell reports 2024 Feb 27;43(2):113749
Cell reports 2024 Feb 27;43(2):113749
KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC.
Li J, Shi D, Li S, Shi X, Liu Y, Zhang Y, Wang G, Zhang C, Xia T, Piao HL, Liu HX
Cell death & disease 2024 Feb 27;15(2):175
Cell death & disease 2024 Feb 27;15(2):175
CUL3 induces mitochondrial dysfunction via MRPL12 ubiquitination in renal tubular epithelial cells.
Ji X, Yang X, Gu X, Chu L, Sun S, Sun J, Song P, Mu Q, Wang Y, Sun X, Su D, Su T, Hou S, Lu Y, Ma C, Liu M, Zhang T, Zhang W, Liu Y, Wan Q
The FEBS journal 2023 Nov;290(22):5340-5352
The FEBS journal 2023 Nov;290(22):5340-5352
DDRGK1 Enhances Osteosarcoma Chemoresistance via Inhibiting KEAP1-Mediated NRF2 Ubiquitination.
Wang X, Zhou T, Yang X, Cao X, Jin G, Zhang P, Guo J, Rong K, Li B, Hu Y, Liu K, Ma P, Qin A, Zhao J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(14):e2204438
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(14):e2204438
Norcantharidin promotes cancer radiosensitization through Cullin1 neddylation-mediated CDC6 protein degradation.
Deng T, Zhu Q, Xie L, Liu Y, Peng Y, Yin L, Gao Y, Cao T, Fu Y, Qi X, Zhang S, Peng Y, Hou Y, Li X
Molecular carcinogenesis 2022 Aug;61(8):812-824
Molecular carcinogenesis 2022 Aug;61(8):812-824
SQSTM1/ p62 oligomerization contributes to Aβ-induced inhibition of Nrf2 signaling.
Guo C, Zhang Y, Nie Q, Cao D, Wang X, Wan X, Liu M, Cui J, Sun J, Bai Y, Li L
Neurobiology of aging 2021 Feb;98:10-20
Neurobiology of aging 2021 Feb;98:10-20
Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination.
Wang Y, Jin R, Chen J, Cao J, Xiao J, Li X, Sun C
Food chemistry 2021 Dec 15;365:130470
Food chemistry 2021 Dec 15;365:130470
USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway.
Zhang L, Gao X, Qin Z, Shi X, Xu K, Wang S, Tang M, Wang W, Gao S, Zuo L, Zhang L, Zhang W
The Science of the total environment 2021 Aug 20;783:146898
The Science of the total environment 2021 Aug 20;783:146898
Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition by targeting ZEB1 for proteasomal degradation in hepatocellular carcinoma.
Dong X, Han Y, Zhang E, Wang Y, Zhang P, Wang C, Zhong L, Li Q
Aging 2021 Apr 4;13(7):10603-10618
Aging 2021 Apr 4;13(7):10603-10618
Arsenic trioxide (ATO) induced degradation of Cyclin D1 sensitized PD-1/PD-L1 checkpoint inhibitor in oral and esophageal squamous cell carcinoma.
Zhu G, Li X, Li J, Zhou W, Chen Z, Fan Y, Jiang Y, Zhao Y, Sun G, Mao W
Journal of Cancer 2020;11(22):6516-6529
Journal of Cancer 2020;11(22):6516-6529
KLHL18 inhibits the proliferation, migration, and invasion of non-small cell lung cancer by inhibiting PI3K/PD-L1 axis activity.
Jiang X, Xu Y, Ren H, Jiang J, Wudu M, Wang Q, Guan J, Su H, Zhang Y, Zhang B, Guo Y, Hu Y, Jiang L, Liu Z, Wang H, Cheng Y, Sun L, Qiu X
Cell & bioscience 2020 Nov 27;10(1):139
Cell & bioscience 2020 Nov 27;10(1):139
The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina.
Toulis V, García-Monclús S, de la Peña-Ramírez C, Arenas-Galnares R, Abril JF, Todi SV, Khan N, Garanto A, Costa MDC, Marfany G
Cell reports 2020 Nov 10;33(6):108360
Cell reports 2020 Nov 10;33(6):108360
Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.
Wang Z, Cai L, Li H, Liang M, Zhang Y, Wu Q, Yang L
Journal of food biochemistry 2020 May;44(5):e13180
Journal of food biochemistry 2020 May;44(5):e13180
Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.
Li H, Liang M, Wang Z, Zhang Y, Wu Q, Yang L
Journal of medicinal food 2020 Jun;23(6):565-574
Journal of medicinal food 2020 Jun;23(6):565-574
l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.
Wang Z, Liang M, Li H, Cai L, He H, Wu Q, Yang L
Journal of the science of food and agriculture 2019 Aug 15;99(10):4849-4862
Journal of the science of food and agriculture 2019 Aug 15;99(10):4849-4862
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Liang M, Wang Z, Li H, Cai L, Pan J, He H, Wu Q, Tang Y, Ma J, Yang L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
Increased Expression of Cullin 3 in Nasopharyngeal Carcinoma and Knockdown Inhibits Proliferation and Invasion.
Zeng R, Tan G, Li W, Ma Y
Oncology research 2018 Jan 19;26(1):111-122
Oncology research 2018 Jan 19;26(1):111-122
H(2)S regulates endothelial nitric oxide synthase protein stability by promoting microRNA-455-3p expression.
Li XH, Xue WL, Wang MJ, Zhou Y, Zhang CC, Sun C, Zhu L, Liang K, Chen Y, Tao BB, Tan B, Yu B, Zhu YC
Scientific reports 2017 Mar 21;7:44807
Scientific reports 2017 Mar 21;7:44807
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 11107-1-AP(CUL3 antibody) at dilution of 1:200
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CUL3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CUL3. This antibody recognizes human,mouse,rat antigen. The CUL3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
