66830-1-Ig

antibody from Proteintech Group

Targeting: APOE AD2

Provider product page for 66830-1-Ig

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [28]
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Product number: 66830-1-Ig - Provider product page
Provider: Proteintech Group
Product name: APOE antibody
Antibody type: Monoclonal
Description: APOE antibody (Cat. #66830-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human, Mouse
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1B2C9
Vial size: 20ul, 150ul

APOE protein structure - 66830-1-Ig shown in red.

Submitted references Endothelial MerTK impairment promotes cardiac dysfunction in the condition of high fat diet.

Huang H, Liu S, Yao J, Bai X, Jin Z, Xue B, Shi H, Ding Z
Redox biology 2026 Jun;93:104184

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression.

Shi J, Li Z, Sun X, Yang Y, Luo Y, Song Z, Dong H, Jin L, Xie J, Shan Y, Zhao G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(2):e05778

APOE suppresses osteosarcoma by modulating ferroptosis through the mTOR/Stat3 signaling pathway.

Cheng X, Bian C, Zhang Y, Gu H, Chen G, Wu L
Archives of medical science : AMS 2025;21(6):2647-2670

Subtype-specific NK cell-TAM interactions drive a novel prognostic signature in HNSCC.

Zhao Z, Han X, Hu Y, Li Y, He Y, Wang Y, Yao Y, Li H, Wei J
Frontiers in immunology 2025;16:1676878

Lipid metabolism and osteonecrosis: unraveling causal mechanisms via multi-omics and mendelian randomization.

Chen Y, Zhou Z, Che H, Li D
Frontiers in physiology 2025;16:1642153

ABCA8-positive lipid-metabolic CAFs mediate immunotherapy resistance in TNBC.

Qin W, Li D, Zhang J, Wang S, Hou L, Zhang C, Wang D, Zhang J
Frontiers in oncology 2025;15:1729275

Malignant epithelia cells-derived spermine induces APOE+ macrophages to suppress tumor immunity in adenocarcinoma of the esophagogastric junction.

Zhang Y, Liu Z, Sun H, Wang Z, Chen Y, Hu Z, Li X, Xu K, Chen Y, Xu Y, Wang C, Xu S
Frontiers in medicine 2025;12:1636699

The APOE ε4 allele affects the survival of patients with Parkinson's disease independent of dementia.

Wang Z, Li L, Xu Q, Pan H, Wang Y, Long Q, Huang Y, Dai Y, Zhang S, Zhou Q, Zhao G, Li B, Tang B, Qiu J, Li J
Journal of translational medicine 2025 Oct 14;23(1):1094

Endothelial MerTK impairment accelerates the development of atherosclerosis.

Liu S, Yao J, Huang H, Bai X, Wu J, Banerjee O, Jin Z, Xue B, Shi H, Ding Z
Redox biology 2025 Nov;87:103861

A Novel Self-Regulated, Non-Directional Magnetic Thermos-Brachytherapy (125)I Seed Enhances Anticancer Efficacy by Rescuing Immune Escape.

Xu B, Wu YM, Cheng YF, Dong L, Ding SW, Chen SR, Chen BD, Yang RP, Zhang WH, Wang YJ, Mao WP, Shi F, Jin ZC, Chen JJ, Qiao EQ, Wang YQ, Li JZ, Zeng P, Wu CW, Zhang W, Xie JB, Lu J, Teng GJ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e08091

Single-cell and spatial RNA sequencing identify divergent microenvironments and progression signatures in early- versus late-onset prostate cancer.

Cheng Y, Liu B, Xin J, Wu X, Li W, Shang J, Wu J, Zhang Z, Xu B, Du M, Cheng G, Wang M
Nature aging 2025 May;5(5):909-928

Egln3 expression in microglia enhances the neuroinflammatory responses in Alzheimer's disease.

Guan J, Wu P, Liu M, Jiang C, Meng X, Wu X, Lu M, Fan Y, Gan L
Brain, behavior, and immunity 2025 Mar;125:21-32

Apolipoprotein E Immunostaining Has Diagnostic Utility in Differentiating Dense Deposit Disease and C3 Glomerulonephritis: Clone-Based Evaluation of D719N, EP1373Y, and 1B2C9.

Hurdogan O, Mirioglu S, Dirim AB, Doksan M, Yuruk Yildirim ZN, Turkmen A, Kilicaslan I, Ozluk Y
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2025 Dec;38(12):100874

SerpinA3N-APOE interaction in astrocytes exacerbates Alzheimer's disease progression through NFκB activation.

Liu C, Xu S, Yao H, Wang Y, Liu Q, Zhou H, Luo Y, Li X, Li S, Li C
Journal of neuroinflammation 2025 Dec 4;23(1):8

Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor-Stroma Ratio and Promote Cancer Progression.

Lou X, Shi Y, Zhao F, Xu X, Wang Y, Qin Y, Zhang W, Ye Z, Wang F, Ding T, Jing D, Fan G, Zhang Y, Chen X, Chen J, Yu X, Xu J, Ji S
Cancer research 2025 Aug 1;85(15):2805-2819

hUC-MSCs Prevent Acute High-Altitude Injury through Apoe/Pdgf-b/p-Erk1/2 Axis in Mice.

Yan S, Bi Y, Liu Q, Song S, Ma L, Ji G
Stem cell reviews and reports 2025 Apr;21(3):834-848

Circulating extracellular vesicles from severe COVID-19 patients induce lung inflammation.

Qian H, Zang R, Zhang R, Zheng G, Qiu G, Meng J, Wang J, Xia J, Huang R, Le Z, Shu Q, Xu J
mSphere 2024 Nov 21;9(11):e0076424

Pan-Cancer Single-Cell and Spatial-Resolved Profiling Reveals the Immunosuppressive Role of APOE+ Macrophages in Immune Checkpoint Inhibitor Therapy.

Liu C, Xie J, Lin B, Tian W, Wu Y, Xin S, Hong L, Li X, Liu L, Jin Y, Tang H, Deng X, Zou Y, Zheng S, Fang W, Cheng J, Dai X, Bao X, Zhao P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(23):e2401061

Leukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis.

Xian M, Wang Q, Xiao L, Zhong L, Xiong W, Ye L, Su P, Zhang C, Li Y, Orlowski RZ, Zhan F, Ganguly S, Zu Y, Qian J, Yi Q
Nature communications 2024 Jul 9;15(1):5767

Single-cell RNA sequencing of cervical exfoliated cells reveals potential biomarkers and cellular pathogenesis in cervical carcinogenesis.

Sheng B, Pan S, Ye M, Liu H, Zhang J, Zhao B, Ji H, Zhu X
Cell death & disease 2024 Feb 12;15(2):130

Rab2A-mediated Golgi-lipid droplet interactions support very-low-density lipoprotein secretion in hepatocytes.

Xu M, Chen ZY, Li Y, Li Y, Guo G, Dai RZ, Ni N, Tao J, Wang HY, Chen QL, Wang H, Zhou H, Yang YN, Chen S, Chen L
The EMBO journal 2024 Dec;43(24):6383-6409

Identification of high-performing antibodies for Apolipoprotein E for use in Western Blot and immunoprecipitation.

Ayoubi R, Southern K, Laflamme C, NeuroSGC/YCharOS collaborative group
F1000Research 2023;12:810

Discovery of lipid profiles in plasma-derived extracellular vesicles as biomarkers for breast cancer diagnosis.

Liu L, Kawashima M, Sugimoto M, Sonomura K, Pu F, Li W, Takeda M, Goto T, Kawaguchi K, Sato TA, Toi M
Cancer science 2023 Oct;114(10):4020-4031

Lack of ApoE inhibits ADan amyloidosis in a mouse model of familial Danish dementia.

Fernandez A, Gomez MT, Vidal R
The Journal of biological chemistry 2023 Jan;299(1):102751

Lipid-accumulated reactive astrocytes promote disease progression in epilepsy.

Chen ZP, Wang S, Zhao X, Fang W, Wang Z, Ye H, Wang MJ, Ke L, Huang T, Lv P, Jiang X, Zhang Q, Li L, Xie ST, Zhu JN, Hang C, Chen D, Liu X, Yan C
Nature neuroscience 2023 Apr;26(4):542-554

Single-cell and spatial analyses reveal the association between gene expression of glutamine synthetase with the immunosuppressive phenotype of APOE+CTSZ+TAM in cancers.

Wei J, Yu W, Chen J, Huang G, Zhang L, Chen Z, Hu M, Gong X, Du H
Molecular oncology 2023 Apr;17(4):611-628

Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures.

Alberts A, Klingberg A, Hoffmeister L, Wessig AK, Brand K, Pich A, Neumann K
Frontiers in immunology 2020;11:596103

A critical role of VMP1 in lipoprotein secretion.

Morishita H, Zhao YG, Tamura N, Nishimura T, Kanda Y, Sakamaki Y, Okazaki M, Li D, Mizushima N
eLife 2019 Sep 17;8

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