Antibody data
- Antibody Data
- Antigen structure
- References [30]
- Comments [0]
- Validations [0]
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- Product number
- 18254-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- APOE antibody
- Antibody type
- Polyclonal
- Description
- APOE antibody (Cat. #18254-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Immune cells regulate circulating adipocyte extracellular vesicle levels in response to metabolic shifts.
Single-cell sequencing reveals APOE deletion alleviates adipose wasting in cancer cachexia via macrophage repolarization.
Malignant epithelia cells-derived spermine induces APOE+ macrophages to suppress tumor immunity in adenocarcinoma of the esophagogastric junction.
Multi-omic analysis reveals retinoic acid molecular drivers for dermal fibrosis and regenerative repair in the skin.
Multi-Omics Profiling Identifies Apolipoprotein E as an Important Regulator of Steroidogenesis in Bactrian Camel Poll Glands During the Breeding Season.
HIF-1α-induced microglia-mediated neuroinflammation is involved in Alzheimer's disease: Evidence from single-cell transcriptomic analysis.
APOE Drives Glioma Progression by Modulating CCL5/CCR5 Signaling in the Tumor Microenvironment and Inducing M2 Macrophage Polarization.
Inducible global knockout of surfeit locus protein 4 in adult mice results in hypolipidemia, intestinal lipid accumulation, liver injury, and increased mortality.
Proteomic Profiling and Therapeutic Targeting of Oxidative Stress in Autoimmune Encephalitis.
Multi-omics and machine learning-driven CD8(+) T cell heterogeneity score for head and neck squamous cell carcinoma.
ATP11B Modulates Microglial Lipid Metabolism and Alleviates Alzheimer's Disease Pathology.
Multi-omics analysis-based macrophage differentiation-associated papillary thyroid cancer patient classifier.
Single-cell sequencing of facial adipose tissue unveils FKBP5 as a therapeutic target for facial infiltrating lipomatosis.
Single-cell RNA profiling reveals classification and characteristics of mononuclear phagocytes in colorectal cancer.
Trilobatin attenuates cerebral ischaemia/reperfusion-induced blood-brain barrier dysfunction by targeting matrix metalloproteinase 9: The legend of a food additive.
Identification of high-performing antibodies for Apolipoprotein E for use in Western Blot and immunoprecipitation.
Single-cell RNA sequencing of retina revealed novel transcriptional landscape in high myopia and underlying cell-type-specific mechanisms.
Single-Cell RNA Sequencing of Coronary Perivascular Adipose Tissue From End-Stage Heart Failure Patients Identifies SPP1(+) Macrophage Subpopulation as a Target for Alleviating Fibrosis.
Apolipoprotein E facilitates titanium implant osseointegration by regulating osteogenesis-lipogenesis balance.
Lipid-accumulated reactive astrocytes promote disease progression in epilepsy.
Identification of hub genes and pathways in lung metastatic colorectal cancer.
Role and mechanism of the zinc finger protein ZNF580 in foam-cell formation.
Effects of apolipoprotein E on regulating insulin sensitivity via regulating insulin receptor signalosome in caveolae.
Protective effects of adipose-derived biogenic nanoparticles on the pulmonary microvascular endothelial barrier in mice with ventilator-induced lung injury via the TRPV4/ROCK1 signalling pathway.
Inclisiran inhibits oxidized low-density lipoprotein-induced foam cell formation in Raw264.7 macrophages via activating the PPARγ pathway.
Serine protease HtrA2/Omi regulates adaptive mitochondrial reprogramming in the brain cortex after ischemia/reperfusion injury via UCP2-SIRT3-PGC1 axis.
SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway.
Comprehensive lipidomics in apoM(-/-) mice reveals an overall state of metabolic distress and attenuated hepatic lipid secretion into the circulation.
SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway.
A new panel of pancreatic cancer biomarkers discovered using a mass spectrometry-based pipeline.
Tiash S, Patel SA, Russo M, Suresh A, Pang B, Pai YL, Jia W, Field RL, Pietka T, Abumrad NA, Smith GI, Samovski D, Klein S, Brestoff JR, Crewe C
Cell metabolism 2026 May 5;38(5):929-943.e8
Cell metabolism 2026 May 5;38(5):929-943.e8
Single-cell sequencing reveals APOE deletion alleviates adipose wasting in cancer cachexia via macrophage repolarization.
Han J, Yao Q, Huang Q, Ding Z, Wu G
Clinical immunology (Orlando, Fla.) 2026 Feb;283:110660
Clinical immunology (Orlando, Fla.) 2026 Feb;283:110660
Malignant epithelia cells-derived spermine induces APOE+ macrophages to suppress tumor immunity in adenocarcinoma of the esophagogastric junction.
Zhang Y, Liu Z, Sun H, Wang Z, Chen Y, Hu Z, Li X, Xu K, Chen Y, Xu Y, Wang C, Xu S
Frontiers in medicine 2025;12:1636699
Frontiers in medicine 2025;12:1636699
Multi-omic analysis reveals retinoic acid molecular drivers for dermal fibrosis and regenerative repair in the skin.
Griffin M, Guo JL, Parker JBL, Kuhnert M, Li DJ, Valencia C, Morgan A, Downer M, Cotterell AC, Lu JM, Dilorio S, Bauer-Rowe Ramos KE, Januszyk M, Chang HY, Wan DC, Longaker MT
Cell stem cell 2025 Sep 4;32(9):1421-1437.e6
Cell stem cell 2025 Sep 4;32(9):1421-1437.e6
Multi-Omics Profiling Identifies Apolipoprotein E as an Important Regulator of Steroidogenesis in Bactrian Camel Poll Glands During the Breeding Season.
Ma Q, Zhang B, Li J, Zhang Q
Animals : an open access journal from MDPI 2025 Oct 30;15(21)
Animals : an open access journal from MDPI 2025 Oct 30;15(21)
HIF-1α-induced microglia-mediated neuroinflammation is involved in Alzheimer's disease: Evidence from single-cell transcriptomic analysis.
Dong M, Qian Y, Geng Y, Wang R, Wang Y, Cai J, Wang X, Huang Y, Liu Y, Liu W, Wu Q, Shen Y
Journal of Alzheimer's disease : JAD 2025 Nov;108(2):643-660
Journal of Alzheimer's disease : JAD 2025 Nov;108(2):643-660
APOE Drives Glioma Progression by Modulating CCL5/CCR5 Signaling in the Tumor Microenvironment and Inducing M2 Macrophage Polarization.
Huang W, Li W, Chen X, Xiang C, Luo K
Immunobiology 2025 May;230(3):152895
Immunobiology 2025 May;230(3):152895
Inducible global knockout of surfeit locus protein 4 in adult mice results in hypolipidemia, intestinal lipid accumulation, liver injury, and increased mortality.
Chen W, Chen Y, Song B, Zhai L, Tao G, Wang B, Liu B, Wang H, Zhang CX, Gu HM, Yin D, Qin S, Zhang DW
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Mar;1870(2):159577
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Mar;1870(2):159577
Proteomic Profiling and Therapeutic Targeting of Oxidative Stress in Autoimmune Encephalitis.
Zhang F, Zhang C, Sun W, Xie S, Wu P, Zeng G, Liu X
Journal of molecular neuroscience : MN 2025 Mar 19;75(2):38
Journal of molecular neuroscience : MN 2025 Mar 19;75(2):38
Multi-omics and machine learning-driven CD8(+) T cell heterogeneity score for head and neck squamous cell carcinoma.
He D, Yang Z, Zhang T, Luo Y, Peng L, Yan J, Qiu T, Zhang J, Qin L, Liu Z, Sun M
Molecular therapy. Nucleic acids 2025 Mar 11;36(1):102413
Molecular therapy. Nucleic acids 2025 Mar 11;36(1):102413
ATP11B Modulates Microglial Lipid Metabolism and Alleviates Alzheimer's Disease Pathology.
Zhang Y, Zhang S, Zhao X, Wu P, Ying Y, Wu L, Zhuang J, Chen Z, Chao Y, Dong X, Zhao RC, Wang J
MedComm 2025 Apr;6(4):e70139
MedComm 2025 Apr;6(4):e70139
Multi-omics analysis-based macrophage differentiation-associated papillary thyroid cancer patient classifier.
Sun H, Chang Z, Li H, Tang Y, Liu Y, Qiao L, Feng G, Huang R, Han D, Yin DT
Translational oncology 2024 May;43:101889
Translational oncology 2024 May;43:101889
Single-cell sequencing of facial adipose tissue unveils FKBP5 as a therapeutic target for facial infiltrating lipomatosis.
Chen H, Sun B, Chang SJ, Yu Z, Qiu Y, Hua C, Lin X
Stem cell research & therapy 2024 Jul 18;15(1):209
Stem cell research & therapy 2024 Jul 18;15(1):209
Single-cell RNA profiling reveals classification and characteristics of mononuclear phagocytes in colorectal cancer.
Ji T, Fu H, Wang L, Chen J, Tian S, Wang G, Wang L, Wang Z
PLoS genetics 2024 Feb;20(2):e1011176
PLoS genetics 2024 Feb;20(2):e1011176
Trilobatin attenuates cerebral ischaemia/reperfusion-induced blood-brain barrier dysfunction by targeting matrix metalloproteinase 9: The legend of a food additive.
Feng L, Li Y, Lin M, Xie D, Luo Y, Zhang Y, He Z, Gong Q, Zhun ZY, Gao J
British journal of pharmacology 2024 Apr;181(7):1005-1027
British journal of pharmacology 2024 Apr;181(7):1005-1027
Identification of high-performing antibodies for Apolipoprotein E for use in Western Blot and immunoprecipitation.
Ayoubi R, Southern K, Laflamme C, NeuroSGC/YCharOS collaborative group
F1000Research 2023;12:810
F1000Research 2023;12:810
Single-cell RNA sequencing of retina revealed novel transcriptional landscape in high myopia and underlying cell-type-specific mechanisms.
Yao Y, Chen Z, Wu Q, Lu Y, Zhou X, Zhu X
MedComm 2023 Oct;4(5):e372
MedComm 2023 Oct;4(5):e372
Single-Cell RNA Sequencing of Coronary Perivascular Adipose Tissue From End-Stage Heart Failure Patients Identifies SPP1(+) Macrophage Subpopulation as a Target for Alleviating Fibrosis.
Fu M, Shu S, Peng Z, Liu X, Chen X, Zeng Z, Yang Y, Cui H, Zhao R, Wang X, Du L, Wu M, Feng W, Song J
Arteriosclerosis, thrombosis, and vascular biology 2023 Nov;43(11):2143-2164
Arteriosclerosis, thrombosis, and vascular biology 2023 Nov;43(11):2143-2164
Apolipoprotein E facilitates titanium implant osseointegration by regulating osteogenesis-lipogenesis balance.
Wang YN, Yu L, Wang T, Liu S
International journal of biological macromolecules 2023 May 1;236:123998
International journal of biological macromolecules 2023 May 1;236:123998
Lipid-accumulated reactive astrocytes promote disease progression in epilepsy.
Chen ZP, Wang S, Zhao X, Fang W, Wang Z, Ye H, Wang MJ, Ke L, Huang T, Lv P, Jiang X, Zhang Q, Li L, Xie ST, Zhu JN, Hang C, Chen D, Liu X, Yan C
Nature neuroscience 2023 Apr;26(4):542-554
Nature neuroscience 2023 Apr;26(4):542-554
Identification of hub genes and pathways in lung metastatic colorectal cancer.
Dai W, Guo C, Wang Y, Li Y, Xie R, Wu J, Yao B, Xie D, He L, Li Y, Huang H, Wang Y, Liu S
BMC cancer 2023 Apr 6;23(1):323
BMC cancer 2023 Apr 6;23(1):323
Role and mechanism of the zinc finger protein ZNF580 in foam-cell formation.
Zhang Z, Qin X, Liu J, Li Y, Chen H, Xie H, Chen J, Li C, Tong Y, Yang M, Zhang M
Experimental and therapeutic medicine 2022 Sep;24(3):579
Experimental and therapeutic medicine 2022 Sep;24(3):579
Effects of apolipoprotein E on regulating insulin sensitivity via regulating insulin receptor signalosome in caveolae.
Liu M, Chen MY, An L, Ma SQ, Mei J, Huang WH, Zhang W
Life sciences 2022 Nov 1;308:120929
Life sciences 2022 Nov 1;308:120929
Protective effects of adipose-derived biogenic nanoparticles on the pulmonary microvascular endothelial barrier in mice with ventilator-induced lung injury via the TRPV4/ROCK1 signalling pathway.
Yu Q, Wang D, Fan S, Tang X, He J, Peng J, Qi D
Pulmonary pharmacology & therapeutics 2022 Jun;73-74:102123
Pulmonary pharmacology & therapeutics 2022 Jun;73-74:102123
Inclisiran inhibits oxidized low-density lipoprotein-induced foam cell formation in Raw264.7 macrophages via activating the PPARγ pathway.
Wang Z, Chen X, Liu J, Wang Y, Zhang S
Autoimmunity 2022 Jun;55(4):223-232
Autoimmunity 2022 Jun;55(4):223-232
Serine protease HtrA2/Omi regulates adaptive mitochondrial reprogramming in the brain cortex after ischemia/reperfusion injury via UCP2-SIRT3-PGC1 axis.
Meng H, Sun LK, Su J, Yan WY, Jin Y, Luo X, Jiang XR, Wang HL
Human cell 2022 Jan;35(1):63-82
Human cell 2022 Jan;35(1):63-82
SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway.
Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Fuchs SY, Connor JH, Douam F, Emili A, Saeed M
Journal of virology 2021 Sep 9;95(19):e0086221
Journal of virology 2021 Sep 9;95(19):e0086221
Comprehensive lipidomics in apoM(-/-) mice reveals an overall state of metabolic distress and attenuated hepatic lipid secretion into the circulation.
Shi Y, Lam SM, Liu H, Luo G, Zhang J, Yao S, Li J, Zheng L, Xu N, Zhang X, Shui G
Journal of genetics and genomics = Yi chuan xue bao 2020 Sep 20;47(9):523-534
Journal of genetics and genomics = Yi chuan xue bao 2020 Sep 20;47(9):523-534
SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway.
Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Kapell S, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Connor JH, Douam F, Emili A, Saeed M
bioRxiv : the preprint server for biology 2020 Oct 28;
bioRxiv : the preprint server for biology 2020 Oct 28;
A new panel of pancreatic cancer biomarkers discovered using a mass spectrometry-based pipeline.
Liu X, Zheng W, Wang W, Shen H, Liu L, Lou W, Wang X, Yang P
British journal of cancer 2017 Dec 5;117(12):1846-1854
British journal of cancer 2017 Dec 5;117(12):1846-1854
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