orb148114

antibody from Biorbyt

Targeting: CENPA CenH3, CENP-A

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

orb148114

Provider

Biorbyt

Product name

CENP-A Antibody: PerCP

Antibody type

Monoclonal

Description

Mouse monoclonal to CENP-A (PerCP). A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. The Centromere Protein-A, CENP-A, is a Histone H3-like protein that contains a C-terminal H3-like domain, which is required for centromere localization of CENP-A, and an antigenic N-terminal domain. CENP-A, originally isolated from HeLa cells, is essential for kinetochore targeting of CENP-C. In the presence of DNA CENP-A forms an octa-meric complex with histones H4, H2A, H2B. CENP-A specifically localizes to active centromeres and is a component of specialized centromeric nucleosomes, on which kinetochores are assembled. CENP-A is essential for nucleosomal packaging of centromeric DNA at interphase and functions as a centromere formation marker on the chromosome..

Reactivity

Human

Host

Mouse

Conjugate

Red dye

Isotype

IgG

Antibody clone number

5A7-2E11

Vial size

100 ug

Concentration

1 mg/ml

Storage

Conjugated antibodies should be stored according to the product label