Antibody data
- Antibody Data
- Antigen structure
- References [33]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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Validation data
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- Product number
- 15518-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15518-1-AP, RRID:AB_2263448
- Product name
- Beta Galactosidase antibody
- Antibody type
- Polyclonal
- Description
- Beta Galactosidase antibody (Cat. #15518-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references P16(INK4a) deletion alleviates contrast-induced acute kidney injury by ameliorating renal cell apoptosis and suppressing inflammation and oxidative stress.
Upregulation of CD8(+) regulatory T cells following liver-directed AAV gene therapy.
Early Pulmonary Fibrosis-like Changes in the Setting of Heat Exposure: DNA Damage and Cell Senescence.
Ultrasound Stimulation of Piezoelectric Nanocomposite Hydrogels Boosts Chondrogenic Differentiation in Vitro, in Both a Normal and Inflammatory Milieu.
HIF-1α/m(6)A/NF-κB/CCL3 axis-mediated immunosurveillance participates in low level benzene-related erythrohematopoietic development toxicity.
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.
Inhibition of Indoxyl Sulfate-Induced Reactive Oxygen Species-Related Ferroptosis Alleviates Renal Cell Injury In Vitro and Chronic Kidney Disease Progression In Vivo.
Integrin β3-Mediated Cell Senescence Associates with Gut Inflammation and Intestinal Degeneration in Models of Alzheimer's Disease.
The Expression of αvβ3 and Osteopontin in Osteoarthritic Knee Cartilage and Their Correlations With Disease Severity and Chondrocyte Senescence.
Gene Editing Corrects In Vitro a G > A GLB1 Transition from a GM1 Gangliosidosis Patient.
Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway In Vitro.
p16(INK4a) Plays Critical Role in Exacerbating Inflammaging in High Fat Diet Induced Skin.
Senescent Phenotype of Astrocytes Leads to Activation of BV2 Microglia and N2a Neuronal Cells Death.
Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.
TMT-based quantitative N-glycoproteomic analysis reveals glycoprotein protection can improve the quality of frozen bovine sperm.
The fiber diameter traits of Tibetan cashmere goats are governed by the inherent differences in stress, hypoxic, and metabolic adaptations: an integrative study of proteome and transcriptome.
Liver glycogen phosphorylase is upregulated in glioblastoma and provides a metabolic vulnerability to high dose radiation.
Heat shock protein A12B gene therapy improves perfusion, promotes neovascularization, and decreases fibrosis in a murine model of hind limb ischemia.
Astrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retention.
OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.
Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.
Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG.
Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation.
Extracellular vesicles from adipose-derived stem cells ameliorate ultraviolet B-induced skin photoaging by attenuating reactive oxygen species production and inflammation.
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Sarcopenia is attenuated by TRB3 knockout in aging mice via the alleviation of atrophy and fibrosis of skeletal muscles.
Galactose-modified duocarmycin prodrugs as senolytics.
Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence.
Cardiac glycosides are broad-spectrum senolytics.
Active PKG II inhibited the growth and migration of ovarian cancer cells through blocking Raf/MEK and PI3K/Akt signaling pathways.
β1-integrin is essential for vasoregulation and smooth muscle survival in vivo.
Unhealthy diet and ultrafine carbon black particles induce senescence and disease associated phenotypic changes.
Pioglitazone activates aortic telomerase and prevents stress-induced endothelial apoptosis.
Zhang X, Huang G, Zhang Z, Wang F, Liu Q, Du Y, Wang X, Gu X
Experimental gerontology 2024 Mar;187:112372
Experimental gerontology 2024 Mar;187:112372
Upregulation of CD8(+) regulatory T cells following liver-directed AAV gene therapy.
Gaddie CD, Senior KG, Chan C, Hoffman BE, Keeler GD
Cellular immunology 2024 Mar-Apr;397-398:104806
Cellular immunology 2024 Mar-Apr;397-398:104806
Early Pulmonary Fibrosis-like Changes in the Setting of Heat Exposure: DNA Damage and Cell Senescence.
Hou T, Zhang J, Wang Y, Zhang G, Li S, Fan W, Li R, Sun Q, Liu C
International journal of molecular sciences 2024 Mar 5;25(5)
International journal of molecular sciences 2024 Mar 5;25(5)
Ultrasound Stimulation of Piezoelectric Nanocomposite Hydrogels Boosts Chondrogenic Differentiation in Vitro, in Both a Normal and Inflammatory Milieu.
Ricotti L, Cafarelli A, Manferdini C, Trucco D, Vannozzi L, Gabusi E, Fontana F, Dolzani P, Saleh Y, Lenzi E, Columbaro M, Piazzi M, Bertacchini J, Aliperta A, Cain M, Gemmi M, Parlanti P, Jost C, Fedutik Y, Nessim GD, Telkhozhayeva M, Teblum E, Dumont E, Delbaldo C, Codispoti G, Martini L, Tschon M, Fini M, Lisignoli G
ACS nano 2024 Jan 23;18(3):2047-2065
ACS nano 2024 Jan 23;18(3):2047-2065
HIF-1α/m(6)A/NF-κB/CCL3 axis-mediated immunosurveillance participates in low level benzene-related erythrohematopoietic development toxicity.
Cong X, Li X, Xu K, Yin L, Liang G, Sun R, Pu Y, Zhang J
Environment international 2024 Feb;184:108493
Environment international 2024 Feb;184:108493
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.
He Y, Kaya I, Shariatgorji R, Lundkvist J, Wahlberg LU, Nilsson A, Mamula D, Kehr J, Zareba-Paslawska J, Biverstål H, Chergui K, Zhang X, Andren PE, Svenningsson P
Nature communications 2023 Sep 19;14(1):5804
Nature communications 2023 Sep 19;14(1):5804
Inhibition of Indoxyl Sulfate-Induced Reactive Oxygen Species-Related Ferroptosis Alleviates Renal Cell Injury In Vitro and Chronic Kidney Disease Progression In Vivo.
Tsai LT, Weng TI, Chang TY, Lan KC, Chiang CK, Liu SH
Antioxidants (Basel, Switzerland) 2023 Oct 30;12(11)
Antioxidants (Basel, Switzerland) 2023 Oct 30;12(11)
Integrin β3-Mediated Cell Senescence Associates with Gut Inflammation and Intestinal Degeneration in Models of Alzheimer's Disease.
Tun X, Wang EJ, Gao Z, Lundberg K, Xu R, Hu D
International journal of molecular sciences 2023 Mar 16;24(6)
International journal of molecular sciences 2023 Mar 16;24(6)
The Expression of αvβ3 and Osteopontin in Osteoarthritic Knee Cartilage and Their Correlations With Disease Severity and Chondrocyte Senescence.
Cheng C, Tian J, Gao SG, Zhou ZH, Yang RQ, Xiao K, Guo W, Liu L, Yang H, Zhang FJ
Applied immunohistochemistry & molecular morphology : AIMM 2023 Jan 1;31(1):57-63
Applied immunohistochemistry & molecular morphology : AIMM 2023 Jan 1;31(1):57-63
Gene Editing Corrects In Vitro a G > A GLB1 Transition from a GM1 Gangliosidosis Patient.
Leclerc D, Goujon L, Jaillard S, Nouyou B, Cluzeau L, Damaj L, Dubourg C, Etcheverry A, Levade T, Froissart R, Dréano S, Guillory X, Eriksson LA, Launay E, Mouriaux F, Belaud-Rotureau MA, Odent S, Gilot D
The CRISPR journal 2023 Feb;6(1):17-31
The CRISPR journal 2023 Feb;6(1):17-31
Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway In Vitro.
Li JQ, Jiang HJ, Su XY, Feng L, Zhan NZ, Li SS, Chen ZJ, Chang BH, Cheng PZ, Yang L, Pei GX
Stem cells international 2022;2022:4363632
Stem cells international 2022;2022:4363632
p16(INK4a) Plays Critical Role in Exacerbating Inflammaging in High Fat Diet Induced Skin.
Liang Y, Gu T, Peng S, Lin Y, Liu J, Wang X, Huang X, Zhang X, Zhu J, Zhao L, Fan C, Wang G, Gu X, Lin J
Oxidative medicine and cellular longevity 2022;2022:3415528
Oxidative medicine and cellular longevity 2022;2022:3415528
Senescent Phenotype of Astrocytes Leads to Activation of BV2 Microglia and N2a Neuronal Cells Death.
Zhang W, Yang X, Liu J, Pan Y, Zhang M, Chen L
Molecules (Basel, Switzerland) 2022 Sep 12;27(18)
Molecules (Basel, Switzerland) 2022 Sep 12;27(18)
Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.
Boland S, Swarup S, Ambaw YA, Malia PC, Richards RC, Fischer AW, Singh S, Aggarwal G, Spina S, Nana AL, Grinberg LT, Seeley WW, Surma MA, Klose C, Paulo JA, Nguyen AD, Harper JW, Walther TC, Farese RV Jr
Nature communications 2022 Oct 7;13(1):5924
Nature communications 2022 Oct 7;13(1):5924
TMT-based quantitative N-glycoproteomic analysis reveals glycoprotein protection can improve the quality of frozen bovine sperm.
Wang N, Yang M, He D, Li X, Zhang X, Han B, Liu C, Hai C, Li G, Zhao Y
International journal of biological macromolecules 2022 Oct 1;218:168-180
International journal of biological macromolecules 2022 Oct 1;218:168-180
The fiber diameter traits of Tibetan cashmere goats are governed by the inherent differences in stress, hypoxic, and metabolic adaptations: an integrative study of proteome and transcriptome.
Zhao B, Wu C, Sammad A, Ma Z, Suo L, Wu Y, Fu X
BMC genomics 2022 Mar 7;23(1):191
BMC genomics 2022 Mar 7;23(1):191
Liver glycogen phosphorylase is upregulated in glioblastoma and provides a metabolic vulnerability to high dose radiation.
Zois CE, Hendriks AM, Haider S, Pires E, Bridges E, Kalamida D, Voukantsis D, Lagerholm BC, Fehrmann RSN, den Dunnen WFA, Tarasov AI, Baba O, Morris J, Buffa FM, McCullagh JSO, Jalving M, Harris AL
Cell death & disease 2022 Jun 28;13(6):573
Cell death & disease 2022 Jun 28;13(6):573
Heat shock protein A12B gene therapy improves perfusion, promotes neovascularization, and decreases fibrosis in a murine model of hind limb ischemia.
Thirunavukkarasu M, Tipu Rishi M, Pradeep SR, Swaminathan S, Accorsi D, Palesty JA, Maulik N
Surgery 2021 Sep;170(3):969-977
Surgery 2021 Sep;170(3):969-977
Astrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retention.
Vignoli B, Sansevero G, Sasi M, Rimondini R, Blum R, Bonaldo V, Biasini E, Santi S, Berardi N, Lu B, Canossa M
Communications biology 2021 Oct 5;4(1):1152
Communications biology 2021 Oct 5;4(1):1152
OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.
Tian J, Cheng C, Kuang SD, Su C, Zhao X, Xiong YL, Li YS, Gao SG
Pain research & management 2020;2020:3428587
Pain research & management 2020;2020:3428587
Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.
Zou G, Zhang X, Wang L, Li X, Xie T, Zhao J, Yan J, Wang L, Ye H, Jiao S, Xiang R, Shi Y
Theranostics 2020;10(15):6839-6853
Theranostics 2020;10(15):6839-6853
Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG.
Balakrishnan I, Danis E, Pierce A, Madhavan K, Wang D, Dahl N, Sanford B, Birks DK, Davidson N, Metselaar DS, Meel MH, Lemma R, Donson A, Vijmasi T, Katagi H, Sola I, Fosmire S, Alimova I, Steiner J, Gilani A, Hulleman E, Serkova NJ, Hashizume R, Hawkins C, Carcaboso AM, Gupta N, Monje M, Jabado N, Jones K, Foreman N, Green A, Vibhakar R, Venkataraman S
Cell reports 2020 Oct 20;33(3):108286
Cell reports 2020 Oct 20;33(3):108286
Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation.
Shen L, Kang L, Wang D, Xun J, Chen C, Du L, Zhang M, Gong J, Mi X, Yue S, Zhang Y, Song X, Xiang R, Zhang Z, Tan X
Cancer letters 2020 Mar 1;472:40-49
Cancer letters 2020 Mar 1;472:40-49
Extracellular vesicles from adipose-derived stem cells ameliorate ultraviolet B-induced skin photoaging by attenuating reactive oxygen species production and inflammation.
Xu P, Xin Y, Zhang Z, Zou X, Xue K, Zhang H, Zhang W, Liu K
Stem cell research & therapy 2020 Jul 1;11(1):264
Stem cell research & therapy 2020 Jul 1;11(1):264
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Wang J, Li S, Wang J, Wu F, Chen Y, Zhang H, Guo Y, Lin Y, Li L, Yu X, Liu T, Zhao Y
Aging 2020 Jan 6;12(1):650-671
Aging 2020 Jan 6;12(1):650-671
Sarcopenia is attenuated by TRB3 knockout in aging mice via the alleviation of atrophy and fibrosis of skeletal muscles.
Shang GK, Han L, Wang ZH, Liu YP, Yan SB, Sai WW, Wang D, Li YH, Zhang W, Zhong M
Journal of cachexia, sarcopenia and muscle 2020 Aug;11(4):1104-1120
Journal of cachexia, sarcopenia and muscle 2020 Aug;11(4):1104-1120
Galactose-modified duocarmycin prodrugs as senolytics.
Guerrero A, Guiho R, Herranz N, Uren A, Withers DJ, Martínez-Barbera JP, Tietze LF, Gil J
Aging cell 2020 Apr;19(4):e13133
Aging cell 2020 Apr;19(4):e13133
Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence.
Li Y, Li X, Cao M, Jiang Y, Yan J, Liu Z, Yang R, Chen X, Sun P, Xiang R, Wang L, Shi Y
Signal transduction and targeted therapy 2019;4:50
Signal transduction and targeted therapy 2019;4:50
Cardiac glycosides are broad-spectrum senolytics.
Guerrero A, Herranz N, Sun B, Wagner V, Gallage S, Guiho R, Wolter K, Pombo J, Irvine EE, Innes AJ, Birch J, Glegola J, Manshaei S, Heide D, Dharmalingam G, Harbig J, Olona A, Behmoaras J, Dauch D, Uren AG, Zender L, Vernia S, Martínez-Barbera JP, Heikenwalder M, Withers DJ, Gil J
Nature metabolism 2019 Nov;1(11):1074-1088
Nature metabolism 2019 Nov;1(11):1074-1088
Active PKG II inhibited the growth and migration of ovarian cancer cells through blocking Raf/MEK and PI3K/Akt signaling pathways.
Wu Y, Cai Q, Li W, Cai Z, Liu Y, Li H, Pang J, Chen Y
Bioscience reports 2019 Aug 30;39(8)
Bioscience reports 2019 Aug 30;39(8)
β1-integrin is essential for vasoregulation and smooth muscle survival in vivo.
Turlo KA, Scapa J, Bagher P, Jones AW, Feil R, Korthuis RJ, Segal SS, Iruela-Arispe ML
Arteriosclerosis, thrombosis, and vascular biology 2013 Oct;33(10):2325-35
Arteriosclerosis, thrombosis, and vascular biology 2013 Oct;33(10):2325-35
Unhealthy diet and ultrafine carbon black particles induce senescence and disease associated phenotypic changes.
Büchner N, Ale-Agha N, Jakob S, Sydlik U, Kunze K, Unfried K, Altschmied J, Haendeler J
Experimental gerontology 2013 Jan;48(1):8-16
Experimental gerontology 2013 Jan;48(1):8-16
Pioglitazone activates aortic telomerase and prevents stress-induced endothelial apoptosis.
Werner C, Gensch C, Pöss J, Haendeler J, Böhm M, Laufs U
Atherosclerosis 2011 May;216(1):23-34
Atherosclerosis 2011 May;216(1):23-34
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 15518-1-AP(GLB1 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using GLB1 antibody 15518-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line