11-0108-42

antibody from Invitrogen Antibodies
Targeting: MME CALLA, CD10, NEP
Provider product page for 11-0108-42

Antibody data

Product number
11-0108-42 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD10 Monoclonal Antibody (SN5c), FITC, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: The eBioSN5c monoclonal antibody recognizes human CD10 (CALLA, NEP, enkephalinase, Neprilysin), which is a 100 kDa, type II cell surface glycoprotein originally identified for its expression on most acute lymphoblastic leukemias (ALLs). Subsequently, CD10 was shown to be the same molecule as neutral endopeptidase (NEP), or KII-NA. CD10 is a Zn^2+-dependent metallopeptidase acting on substrates such as endothelin, glucagon, gastrin, neurotensin and bradykinin. CD10 is involved in the regulation of chemotactic and inflammatory processes involving neutrophils. In B cells, CD10 regulates stromal cell-dependent B lymphopoiesis and its expression has been reported on mature germinal center B cells. CD10 expression is also found on normal donor granulocytes and bone marrow stromal cells. Most likely, CB-CALLA and eBioSN5c see different epitopes due to their ability to co-stain.
Conjugate
Green dye
Antibody clone number
SN5c
Concentration
5 µL/Test
MME protein structure - 11-0108-42 shown in red.