Antibody data
- Antibody Data
- Antigen structure
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- Product number
- AMM00390G - Provider product page
- Provider
- Leading Biology
- Product name
- Cyclin D1 (G1-Cyclin & Mantle Cell Marker) Antibody - Without BSA and Azide
- Antibody type
- Monoclonal
- Description
- Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). About 40% of breast carcinomas are positive for Cyclin D1. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Mouse
- Antibody clone number
- DCS-6
- Storage
- Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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