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- Antibody Data
- Antigen structure
- References [25]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
- Other assay [2]
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- Product number
- MA5-15237 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Melan-A Monoclonal Antibody (M2-7C10)
- Antibody type
- Monoclonal
- Antigen
- Recombinant full-length protein
- Description
- MA5-15237 targets MART-1 in FACS, IHC (P), IP, and WB applications and shows reactivity with Human samples. The MA5-15237 immunogen is recombinant hMART-1 protein.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- M2-7C10
- Vial size
- 500 µL
- Concentration
- 0.1 mg/mL
- Storage
- 4° C
Submitted references Two novel TSC2 mutations in renal epithelioid angiomyolipoma sensitive to everolimus.
Notch transactivates Rheb to maintain the multipotency of TSC-null cells.
Vaccination with antigen-transfected, NKT cell ligand-loaded, human cells elicits robust in situ immune responses by dendritic cells.
Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes.
Intraglomerular crescentic metastases of malignant melanoma.
Cellular blue nevus of the uterus: a case report and review of the literature.
Glycoprotein nonmetastatic melanoma protein b, a melanocytic cell marker, is a melanosome-specific and proteolytically released protein.
Regulation of human skin pigmentation in situ by repetitive UV exposure: molecular characterization of responses to UVA and/or UVB.
Cyclobutane pyrimidine dimer formation and p53 production in human skin after repeated UV irradiation.
Dendritic cell vaccine with mRNA targeted to the proteasome by polyubiquitination.
Glomus tumor and glomangioma of the nerve. Report of two cases.
Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation.
Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics.
Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi.
McCune-Albright syndrome in a boy may present with a monolateral macroorchidism as an early and isolated clinical manifestation.
Accumulation of low-avidity anti-melanocortin receptor 1 (anti-MC1R) CD8+ T cells in the lesional skin of a patient with melanoma-related depigmentation.
Mechanisms of skin tanning in different racial/ethnic groups in response to ultraviolet radiation.
Immunogenicity, including vitiligo, and feasibility of vaccination with autologous GM-CSF-transduced tumor cells in metastatic melanoma patients.
MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes.
Identification of monoclonal anti-HMW-MAA antibody linear peptide epitope by proteomic database mining.
Computational peptide dissection of Melan-a/MART-1 oncoprotein antigenicity.
On the role of melanoma-specific CD8+ T-cell immunity in disease progression of advanced-stage melanoma patients.
Intraparenchymal nevus cell aggregates in lymph nodes: a possible diagnostic pitfall with malignant melanoma and carcinoma.
Magnetic bead RT-PCR: establishment of a new method for detecting circulating melanoma cells.
Peripheral burst of tumor-specific cytotoxic T lymphocytes and infiltration of metastatic lesions by memory CD8+ T cells in melanoma patients receiving interleukin 12.
Wang T, Xie S, Luo R, Shi L, Bai P, Wang X, Wan R, Deng J, Wu Z, Li W, Xiao W, Wang Y, Chen B, Zhang K, Xing J
Cancer biology & therapy 2020;21(1):4-11
Cancer biology & therapy 2020;21(1):4-11
Notch transactivates Rheb to maintain the multipotency of TSC-null cells.
Cho JH, Patel B, Bonala S, Manne S, Zhou Y, Vadrevu SK, Patel J, Peronaci M, Ghouse S, Henske EP, Roegiers F, Giannikou K, Kwiatkowski DJ, Mansouri H, Markiewski MM, White B, Karbowniczek M
Nature communications 2017 Nov 29;8(1):1848
Nature communications 2017 Nov 29;8(1):1848
Vaccination with antigen-transfected, NKT cell ligand-loaded, human cells elicits robust in situ immune responses by dendritic cells.
Shimizu K, Mizuno T, Shinga J, Asakura M, Kakimi K, Ishii Y, Masuda K, Maeda T, Sugahara H, Sato Y, Matsushita H, Nishida K, Hanada K, Dorrie J, Schaft N, Bickham K, Koike H, Ando T, Nagai R, Fujii S
Cancer research 2013 Jan 1;73(1):62-73
Cancer research 2013 Jan 1;73(1):62-73
Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes.
Pedersen M, Küsters-Vandevelde HVN, Viros A, Groenen PJTA, Sanchez-Laorden B, Gilhuis JH, van Engen-van Grunsven IA, Renier W, Schieving J, Niculescu-Duvaz I, Springer CJ, Küsters B, Wesseling P, Blokx WAM, Marais R
Cancer discovery 2013 Apr;3(4):458-469
Cancer discovery 2013 Apr;3(4):458-469
Intraglomerular crescentic metastases of malignant melanoma.
Ozluk Y, Kilicaslan I, Kazancioglu R, Demirkesen C, Derin D, Mandel NM
Human pathology 2011 Dec;42(12):2025-8
Human pathology 2011 Dec;42(12):2025-8
Cellular blue nevus of the uterus: a case report and review of the literature.
Eskue K, Prieto VG, Malpica A
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2010 Nov;29(6):583-6
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2010 Nov;29(6):583-6
Glycoprotein nonmetastatic melanoma protein b, a melanocytic cell marker, is a melanosome-specific and proteolytically released protein.
Hoashi T, Sato S, Yamaguchi Y, Passeron T, Tamaki K, Hearing VJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 May;24(5):1616-29
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 May;24(5):1616-29
Regulation of human skin pigmentation in situ by repetitive UV exposure: molecular characterization of responses to UVA and/or UVB.
Choi W, Miyamura Y, Wolber R, Smuda C, Reinhold W, Liu H, Kolbe L, Hearing VJ
The Journal of investigative dermatology 2010 Jun;130(6):1685-96
The Journal of investigative dermatology 2010 Jun;130(6):1685-96
Cyclobutane pyrimidine dimer formation and p53 production in human skin after repeated UV irradiation.
Yamaguchi Y, Coelho SG, Zmudzka BZ, Takahashi K, Beer JZ, Hearing VJ, Miller SA
Experimental dermatology 2008 Nov;17(11):916-24
Experimental dermatology 2008 Nov;17(11):916-24
Dendritic cell vaccine with mRNA targeted to the proteasome by polyubiquitination.
Hosoi A, Takeda Y, Sakuta K, Ueha S, Kurachi M, Kimura K, Maekawa R, Kakimi K
Biochemical and biophysical research communications 2008 Jun 27;371(2):242-6
Biochemical and biophysical research communications 2008 Jun 27;371(2):242-6
Glomus tumor and glomangioma of the nerve. Report of two cases.
Scheithauer BW, Rodriguez FJ, Spinner RJ, Dyck PJ, Salem A, Edelman FL, Amrami KK, Fu YS
Journal of neurosurgery 2008 Feb;108(2):348-56
Journal of neurosurgery 2008 Feb;108(2):348-56
Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation.
Dissanayake SK, Olkhanud PB, O'Connell MP, Carter A, French AD, Camilli TC, Emeche CD, Hewitt KJ, Rosenthal DT, Leotlela PD, Wade MS, Yang SW, Brant L, Nickoloff BJ, Messina JL, Biragyn A, Hoek KS, Taub DD, Longo DL, Sondak VK, Hewitt SM, Weeraratna AT
Cancer research 2008 Dec 15;68(24):10205-14
Cancer research 2008 Dec 15;68(24):10205-14
Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics.
Zhang JG, Eguchi J, Kruse CA, Gomez GG, Fakhrai H, Schroter S, Ma W, Hoa N, Minev B, Delgado C, Wepsic HT, Okada H, Jadus MR
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Jan 15;13(2 Pt 1):566-575
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Jan 15;13(2 Pt 1):566-575
Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi.
Bandyopadhyay D, Curry JL, Lin Q, Richards HW, Chen D, Hornsby PJ, Timchenko NA, Medrano EE
Aging cell 2007 Aug;6(4):577-91
Aging cell 2007 Aug;6(4):577-91
McCune-Albright syndrome in a boy may present with a monolateral macroorchidism as an early and isolated clinical manifestation.
Arrigo T, Pirazzoli P, De Sanctis L, Leone O, Wasniewska M, Messina MF, De Luca F
Hormone research 2006;65(3):114-9
Hormone research 2006;65(3):114-9
Accumulation of low-avidity anti-melanocortin receptor 1 (anti-MC1R) CD8+ T cells in the lesional skin of a patient with melanoma-related depigmentation.
Wankowicz-Kalinska A, Mailliard RB, Olson K, Graham F, Edington H, Kirkwood JM, Martinek S, Das PK, Storkus WJ
Melanoma research 2006 Apr;16(2):165-74
Melanoma research 2006 Apr;16(2):165-74
Mechanisms of skin tanning in different racial/ethnic groups in response to ultraviolet radiation.
Tadokoro T, Yamaguchi Y, Batzer J, Coelho SG, Zmudzka BZ, Miller SA, Wolber R, Beer JZ, Hearing VJ
The Journal of investigative dermatology 2005 Jun;124(6):1326-32
The Journal of investigative dermatology 2005 Jun;124(6):1326-32
Immunogenicity, including vitiligo, and feasibility of vaccination with autologous GM-CSF-transduced tumor cells in metastatic melanoma patients.
Luiten RM, Kueter EW, Mooi W, Gallee MP, Rankin EM, Gerritsen WR, Clift SM, Nooijen WJ, Weder P, van de Kasteele WF, Sein J, van den Berk PC, Nieweg OE, Berns AM, Spits H, de Gast GC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005 Dec 10;23(35):8978-91
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005 Dec 10;23(35):8978-91
MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes.
Hoashi T, Watabe H, Muller J, Yamaguchi Y, Vieira WD, Hearing VJ
The Journal of biological chemistry 2005 Apr 8;280(14):14006-16
The Journal of biological chemistry 2005 Apr 8;280(14):14006-16
Identification of monoclonal anti-HMW-MAA antibody linear peptide epitope by proteomic database mining.
Mittelman A, Tiwari R, Lucchese G, Willers J, Dummer R, Kanduc D
The Journal of investigative dermatology 2004 Oct;123(4):670-5
The Journal of investigative dermatology 2004 Oct;123(4):670-5
Computational peptide dissection of Melan-a/MART-1 oncoprotein antigenicity.
Tiwari R, Geliebter J, Lucchese A, Mittelman A, Kanduc D
Peptides 2004 Nov;25(11):1865-71
Peptides 2004 Nov;25(11):1865-71
On the role of melanoma-specific CD8+ T-cell immunity in disease progression of advanced-stage melanoma patients.
van Oijen M, Bins A, Elias S, Sein J, Weder P, de Gast G, Mallo H, Gallee M, Van Tinteren H, Schumacher T, Haanen J
Clinical cancer research : an official journal of the American Association for Cancer Research 2004 Jul 15;10(14):4754-60
Clinical cancer research : an official journal of the American Association for Cancer Research 2004 Jul 15;10(14):4754-60
Intraparenchymal nevus cell aggregates in lymph nodes: a possible diagnostic pitfall with malignant melanoma and carcinoma.
Biddle DA, Evans HL, Kemp BL, El-Naggar AK, Harvell JD, White WL, Iskandar SS, Prieto VG
The American journal of surgical pathology 2003 May;27(5):673-81
The American journal of surgical pathology 2003 May;27(5):673-81
Magnetic bead RT-PCR: establishment of a new method for detecting circulating melanoma cells.
Georgieva J, Milling A, Orfanos CE, Geilen CC
Melanoma research 2002 Aug;12(4):309-17
Melanoma research 2002 Aug;12(4):309-17
Peripheral burst of tumor-specific cytotoxic T lymphocytes and infiltration of metastatic lesions by memory CD8+ T cells in melanoma patients receiving interleukin 12.
Mortarini R, Borri A, Tragni G, Bersani I, Vegetti C, Bajetta E, Pilotti S, Cerundolo V, Anichini A
Cancer research 2000 Jul 1;60(13):3559-68
Cancer research 2000 Jul 1;60(13):3559-68
No comments: Submit comment
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot of MART-1 using MART-1 Monoclonal Antibody (Product # MA5-15237) on CaC1 Cells.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Formalin-fixed, paraffin-embedded human melanoma stained with Mart-1 antibody using peroxidase-conjugate and DAB chromogen. Note cytoplasmic staining of tumor cells.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunoprecipitation of MART-1 using MART-1 Monoclonal Antibody (Product # MA5-15237) on denatured Human IMR-5 Cells.
