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- Antibody Data
- Antigen structure
- References [167]
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- Product number
- 18202-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18202-1-AP, RRID:AB_10597084
- Product name
- Cyclin A2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Cyclin A2 antibody (Cat. #18202-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references MK8722 initiates early-stage autophagy while inhibiting late-stage autophagy via FASN-dependent reprogramming of lipid metabolism.
Isotoosendanin exerts anti-tumor effects in NSCLC by enhancing the stability of SHP-2 and inhibiting the JAK/STAT3 pathway.
Copper Chaperone Atox1 Protected the Cochlea From Cisplatin by Regulating the Copper Transport Family and Cell Cycle.
Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice.
ZNF862 induces cytostasis and apoptosis via the p21-RB1 and Bcl-xL-Caspase 3 signaling pathways in human gingival fibroblasts.
The anti-non-small cell lung cancer effect of Diosbulbin B: Targeting YY1 induced cell cycle arrest and apoptosis.
Combining transcriptomics and network pharmacology to reveal the mechanism of Zuojin capsule improving spasmolytic polypeptide-expressing metaplasia.
Attenuation of pro-tumorigenic senescent secretory phenotype by StN, a novel derivative of stevioside, potentiates its inhibitory activity on hepatocellular carcinoma.
MAPRE3 as an epigenetic target of EZH2 restricts ovarian cancer proliferation in vitro and in vivo.
Dendrobium nobile active ingredient Dendrobin A against hepatocellular carcinoma via inhibiting nuclear factor kappa-B signaling.
Liensinine inhibits progression of intrahepatic cholangiocarcinoma by regulating TGF-β1 /P-smad3 signaling through HIF-1a.
A novel 2-iminobenzimidazole compound, XYA1353, displays in vitro and in vivo anti-myeloma activity via targeting NF-κB signaling.
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis.
Sphingolipid metabolism controls mammalian heart regeneration.
CGRP Released by Corneal Sensory Nerve Maintains Tear Secretion of the Lacrimal Gland.
GPC3 Promotes Lung Squamous Cell Carcinoma Progression and HLA-A2-Restricted GPC3 Antigenic Peptide-Modified Dendritic Cell-Induced Cytotoxic T Lymphocytes to Kill Lung Squamous Cell Carcinoma Cells.
ESRG is critical to maintain the cell survival and self-renewal/pluripotency of hPSCs by collaborating with MCM2 to suppress p53 pathway.
Ebastine exerts antitumor activity and induces autophagy by activating AMPK/ULK1 signaling in an IPMK-dependent manner in osteosarcoma.
Phosphofructokinase Platelet Overexpression Accelerated Colorectal Cancer Cell Growth and Motility.
Inhibition of STAT3 signaling as critical molecular event in HUC-MSCs suppressed Glioblastoma Cells.
Reduced FANCE Confers Genomic Instability and Malignant Behavior by Regulating Cell Cycle Progression in Endometrial Cancer.
Vitamin D3 promotes gastric cancer cell autophagy by mediating p53/AMPK/mTOR signaling.
A Novel Gene Pair CSTF2/DPE2A Impacts Prognosis and Cell Cycle of Hepatocellular Carcinoma.
Nuclear receptor coactivator 6 (NCoA6) promotes cell proliferation, migration, and invasion in pancreatic cancer.
Tumor-promoting action of ubiquitin protease 43 in gastric cancer progression through deubiquitination and stabilization of stress-inducible phosphoprotein 1.
Activation of endoplasmic reticulum stress by harmine suppresses the growth of esophageal squamous cell carcinoma.
CT2-3 induces cell cycle arrest and apoptosis in rheumatoid arthritis fibroblast-like synoviocytes through regulating PI3K/AKT pathway.
Arecoline hydrobromide suppresses PI3K/AKT pathway in rheumatoid arthritis synovial fibroblasts and relieves collagen-induced arthritis in mice.
Modulation of cell cycle increases CRISPR-mediated homology-directed DNA repair.
ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury.
Angelicin inhibits cell growth and promotes apoptosis in oral squamous cell carcinoma by negatively regulating DUSP6/cMYC signaling pathway.
Proline-rich 11 (PRR11) promotes the progression of cutaneous squamous cell carcinoma by activating the EGFR signaling pathway.
LMNB1 deletion in ovarian cancer inhibits the proliferation and metastasis of tumor cells through PI3K/Akt pathway.
An oral phenylacrylic acid derivative suppressed hepatic stellate cell activation and ameliorated liver fibrosis by blocking TGF-β1 signalling.
CDCA4 interacts with IGF2BP1 to regulate lung adenocarcinoma proliferation via the PI3K/AKT pathway.
LIFR recruits HGF-producing neutrophils to promote liver injury repair and regeneration.
Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice.
Modified Podophyllotoxin Phenoxyacetamide Phenylacetate Derivatives: Tubulin/AKT1 Dual-Targeting and Potential Anticancer Agents for Human NSCLC.
Moringa oleifera Lam. Isothiocyanate Quinazolinone Derivatives Inhibit U251 Glioma Cell Proliferation through Cell Cycle Regulation and Apoptosis Induction.
Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells.
Identification of a transcription factor‑cyclin family genes network in lung adenocarcinoma through bioinformatics analysis and validation through RT‑qPCR.
Parasympathetic-macrophages-ductal epithelial cells axis promotes female rat submandibular gland regeneration after excretory duct ligation/deligation.
CgTNF-2 promotes the proliferation of haemocytes by regulating the expressions of CgRunx and cell cycle related genes in the Pacific oyster Crassostrea gigas.
HDAC7/c-Myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cells.
Revealing active components and action mechanism of Fritillariae Bulbus against non-small cell lung cancer through spectrum-effect relationship and proteomics.
TIM-4 orchestrates mitochondrial homeostasis to promote lung cancer progression via ANXA2/PI3K/AKT/OPA1 axis.
Hypoxia Inhibits Cell Cycle Progression and Cell Proliferation in Brain Microvascular Endothelial Cells via the miR-212-3p/MCM2 Axis.
Dual network analysis of transcriptome data for discovery of new therapeutic targets in non-small cell lung cancer.
Effects of dietary folic acid supplementation on lactation performance and mammary epithelial cell development of dairy cows and its regulatory mechanism.
Proteomics, Transcriptomics, and Phosphoproteomics Reveal the Mechanism of Talaroconvolutin-A Suppressing Bladder Cancer via Blocking Cell Cycle and Triggering Ferroptosis.
Sesamol serves as a p53 stabilizer to relieve rheumatoid arthritis progression and inhibits the growth of synovial organoids.
Lnc-PKNOX1-1 inhibits tumor progression in cutaneous malignant melanoma by regulating NF-κB/IL-8 axis.
Z-Ligustilide Combined with Cisplatin Reduces PLPP1-Mediated Phospholipid Synthesis to Impair Cisplatin Resistance in Lung Cancer.
GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1-dependent manner.
PHF23 promotes NSCLC proliferation, metastasis, and chemoresistance via stabilization of ACTN4 and activation of the ERK pathway.
Low-dose graphene oxide promotes tumor cells proliferation by activating PI3K-AKT-mTOR signaling via cellular membrane protein integrin αV.
The potential mechanism of Neu5Gc inducing colorectal cancer based on network pharmacology and experimental validation.
Prepubertal exposure to copper oxide nanoparticles induces Leydig cell injury with steroidogenesis disorders in mouse testes.
8-Methoxyflindersine-Induced Apoptosis and Cell Cycle Disorder Involving MAPK Signaling Activation in Human Colorectal Cancer Cells.
Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells.
Identification and verification of hub genes associated with the progression of non-small cell lung cancer by integrated analysis.
KIFC3 Promotes Proliferation, Migration, and Invasion in Colorectal Cancer via PI3K/AKT/mTOR Signaling Pathway.
Narciclasine inhibits phospholipase A2 and regulates phospholipid metabolism to ameliorate psoriasis-like dermatitis.
A long noncoding RNA GTF2IRD2P1 suppresses cell proliferation in bladder cancer by inhibiting the Wnt/β‑catenin signaling pathway.
Differentiation Capacity of Bone Marrow-Derived Rat Mesenchymal Stem Cells from DsRed and Cre Transgenic Cre/loxP Models.
A natural halogenated fluoride adenosine analog 5'-fluorodeoxy adenosine induced anticolon cancer activity in vivo and in vitro.
Xanthotoxol suppresses non-small cell lung cancer progression and might improve patients' prognosis.
Radix Glycyrrhizae Preparata Induces Cell Cycle Arrest and Induced Caspase-Dependent Apoptosis in Glioblastoma Multiforme.
Spindle and kinetochore-associated complex 3 promotes cell growth via the PI3K/AKT/GSK3β and PI3K/AKT/FOXO1 pathways and is a potential prognostic biomarker for oral squamous cell carcinoma.
Porcine Circovirus 2 Activates the PERK-Reactive Oxygen Species Axis To Induce p53 Phosphorylation with Subsequent Cell Cycle Arrest at S Phase in Favor of Its Replication.
WY-14643 attenuates lipid deposition via activation of the PPARα/CPT1A axis by targeting Gly335 to inhibit cell proliferation and migration in ccRCC.
The substitution of SERCA2 redox cysteine 674 promotes pulmonary vascular remodeling by activating IRE1α/XBP1s pathway.
Novel dual-targeting c-Myc inhibitor D347-2761 represses myeloma growth via blocking c-Myc/Max heterodimerization and disturbing its stability.
Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells.
Effects of 4-vinylcyclohexene diepoxide on the cell cycle, apoptosis, and steroid hormone secretion of goat ovarian granulosa cells.
Simvastatin Downregulates Cofilin and Stathmin to Inhibit Skeletal Muscle Cells Migration.
ALKBH3-dependent m(1)A demethylation of Aurora A mRNA inhibits ciliogenesis.
MCTS1 promotes laryngeal squamous cell carcinoma cell growth via enhancing LARP7 stability.
CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m(6)A-modified CREB1 mRNA.
Disruption of mitochondrial redox homeostasis as a mechanism of antimony-induced reactive oxygen species and cytotoxicity.
c-myc-mediated upregulation of NAT10 facilitates tumor development via cell cycle regulation in non-small cell lung cancer.
PTBP3 regulates proliferation of lung squamous cell carcinoma cells via CDC25A-mediated cell cycle progression.
Anlotinib combined with temozolomide suppresses glioblastoma growth via mediation of JAK2/STAT3 signaling pathway.
Cellular communication network factor 1 interlinks autophagy and ERK signaling to promote osteogenesis of periodontal ligament stem cells.
Comparative oncology reveals DNMT3B as a molecular vulnerability in undifferentiated pleomorphic sarcoma.
Artemisitene suppresses rheumatoid arthritis progression via modulating METTL3-mediated N6-methyladenosine modification of ICAM2 mRNA in fibroblast-like synoviocytes.
The NF-κB/miR-488/ERBB2 axis modulates pancreatic cancer cell malignancy and tumor growth through cell cycle signaling.
Thymidine Kinase 1 Mediates the Synergistic Antitumor Activity of Ubenimex and Celecoxib via Regulation of Cell Cycle in Colorectal Cancer.
Epithelial cells-enriched lncRNA SNHG8 regulates chromatin condensation by binding to Histone H1s.
The Phytochemical Rhein Mediates M(6)A-Independent Suppression of Adipocyte Differentiation.
The ALDH Family Contributes to Immunocyte Infiltration, Proliferation and Epithelial-Mesenchymal Transformation in Glioma.
Induction of Mitosis Delay and Apoptosis by CDDO-TFEA in Glioblastoma Multiforme.
CDCA7 Facilitates Tumor Progression by Directly Regulating CCNA2 Expression in Esophageal Squamous Cell Carcinoma.
Potential Role of SWI/SNF Complex Subunit Actin-Like Protein 6A in Cervical Cancer.
Pinocembrin Inhibits the Proliferation and Metastasis of Breast Cancer via Suppression of the PI3K/AKT Signaling Pathway.
RTA404, an Activator of Nrf2, Activates the Checkpoint Kinases and Induces Apoptosis through Intrinsic Apoptotic Pathway in Malignant Glioma.
β-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight.
Quantitative differences between cyclin-dependent kinases underlie the unique functions of CDK1 in human cells.
Identification of a Proteomic Signature of Senescence in Primary Human Mammary Epithelial Cells.
lncRNA SNHG4 modulates colorectal cancer cell cycle and cell proliferation through regulating miR-590-3p/CDK1 axis.
miR-937-5p targets SOX17 to modulate breast cancer cell cycle and cell proliferation through the Wnt signaling pathway.
UHRF1 Knockdown Attenuates Cell Growth, Migration, and Invasion in Cutaneous Squamous Cell Carcinoma.
Bioinformatics analysis combined with experiments predicts CENPK as a potential prognostic factor for lung adenocarcinoma.
Total saponins from Rhizoma Panacis Majoris inhibit proliferation, induce cell cycle arrest and apoptosis and influence MAPK signalling pathways on the colorectal cancer cell.
SETD4 in the Proliferation, Migration, Angiogenesis, Myogenic Differentiation and Genomic Methylation of Bone Marrow Mesenchymal Stem Cells.
STAT3-mediated activation of mitochondrial pathway contributes to antitumor effect of dihydrotanshinone I in esophageal squamous cell carcinoma cells.
Silencing of ELK3 Induces S-M Phase Arrest and Apoptosis and Upregulates SERPINE1 Expression Reducing Migration in Prostate Cancer Cells.
Ethanol extract of Ophiorrhiza pumila suppresses liver cancer cell proliferation and migration.
Weighted gene co-expression network analysis identifies CCNA2 as a treatment target of prostate cancer through inhibiting cell cycle.
Ursolic Acid Regulates Cell Cycle and Proliferation in Colon Adenocarcinoma by Suppressing Cyclin B1.
The Long Noncoding RNA LOC441461 (STX17-AS1) Modulates Colorectal Cancer Cell Growth and Motility.
A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets.
Mitochondrial UQCC3 Modulates Hypoxia Adaptation by Orchestrating OXPHOS and Glycolysis in Hepatocellular Carcinoma.
Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway.
EVI5 is an oncogene that regulates the proliferation and metastasis of NSCLC cells.
AQP1 modulates tendon stem/progenitor cells senescence during tendon aging.
BRCA1 protects cardiac microvascular endothelial cells against irradiation by regulating p21-mediated cell cycle arrest.
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Blockade of JAK2 protects mice against hypoxia-induced pulmonary arterial hypertension by repressing pulmonary arterial smooth muscle cell proliferation.
Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
IGFBP6 regulates vascular smooth muscle cell proliferation and morphology via cyclin E-CDK2.
Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway.
Magnetic targeting enhances the cutaneous wound healing effects of human mesenchymal stem cell-derived iron oxide exosomes.
Effect of KIF22 on promoting proliferation and migration of gastric cancer cells via MAPK-ERK pathways.
Celastrol attenuates ox-LDL-induced mesangial cell proliferation via suppressing NLRP3 inflammasome activation.
RRM2 is a potential prognostic biomarker with functional significance in glioma.
Enhanced anti-tumor effect of liposomal Fasudil on hepatocellular carcinoma in vitro and in vivo.
The effect of MTHFD2 on the proliferation and migration of colorectal cancer cell lines.
Pterostilbene, An Active Constituent of Blueberries, Suppresses Proliferation Potential of Human Cholangiocarcinoma via Enhancing the Autophagic Flux.
MicroRNA-191 promotes hepatocellular carcinoma cell proliferation by has_circ_0000204/miR-191/KLF6 axis.
Semaphorin 4C Promotes Macrophage Recruitment and Angiogenesis in Breast Cancer.
RANBP9 suppresses tumor proliferation in colorectal cancer.
Lin28 promotes dental pulp cell proliferation via upregulation of cyclin-dependent proteins and interaction with let-7a/IGF2BP2 pathways.
Low C6orf141 Expression is Significantly Associated with a Poor Prognosis in Patients with Oral Cancer.
A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network.
Dual regulatory role of CCNA2 in modulating CDK6 and MET-mediated cell-cycle pathway and EMT progression is blocked by miR-381-3p in bladder cancer.
Fibroblast growth factor-5 promotes spermatogonial stem cell proliferation via ERK and AKT activation.
TROAP regulates prostate cancer progression via the WNT3/survivin signalling pathways.
Metformin Treatment Suppresses Melanoma Cell Growth and Motility Through Modulation of microRNA Expression.
Deficiency of VCP-Interacting Membrane Selenoprotein (VIMP) Leads to G1 Cell Cycle Arrest and Cell Death in MIN6 Insulinoma Cells.
VEGFC/VEGFR3 Signaling Regulates Mouse Spermatogonial Cell Proliferation via the Activation of AKT/MAPK and Cyclin D1 Pathway and Mediates the Apoptosis by affecting Caspase 3/9 and Bcl-2.
Photothermal exposure of polydopamine-coated branched Au-Ag nanoparticles induces cell cycle arrest, apoptosis, and autophagy in human bladder cancer cells.
USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1.
USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization.
Linc00659, a long noncoding RNA, acts as novel oncogene in regulating cancer cell growth in colorectal cancer.
The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression.
PSMB8 regulates glioma cell migration, proliferation, and apoptosis through modulating ERK1/2 and PI3K/AKT signaling pathways.
Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation.
Pseudolaric acid B inhibits neuroglioma cell proliferation through DNA damage response.
Immature colon carcinoma transcript-1 promotes proliferation of gastric cancer cells.
Rheum emodin inhibits enterovirus 71 viral replication and affects the host cell cycle environment.
Therapeutic Targeting of RNA Polymerase I With the Small-Molecule CX-5461 for Prevention of Arterial Injury-Induced Neointimal Hyperplasia.
PTENp1, a natural sponge of miR-21, mediates PTEN expression to inhibit the proliferation of oral squamous cell carcinoma.
G protein subunit α q regulates gastric cancer growth via the p53/p21 and MEK/ERK pathways.
Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro.
Lobaplatin for the treatment of SK-MES-1 lung squamous cell line in vitro and in vivo.
Down-regulation of long non-coding RNA FOXD3 antisense RNA 1 (FOXD3-AS1) inhibits cell proliferation, migration, and invasion in malignant glioma cells.
High Expression of PTGR1 Promotes NSCLC Cell Growth via Positive Regulation of Cyclin-Dependent Protein Kinase Complex.
A novel strategy of profiling the mechanism of herbal medicines by combining network pharmacology with plasma concentration determination and affinity constant measurement.
Overexpression of myosin VI regulates gastric cancer cell progression.
Activation of anaphase-promoting complex by p53 induces a state of dormancy in cancer cells against chemotherapeutic stress.
The Role of the Y Box Binding Protein 1 C-Terminal Domain in Vascular Endothelial Cell Proliferation, Apoptosis, and Angiogenesis.
HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc.
Modulation of cyclins and p53 in mesangial cell proliferation and apoptosis during Habu nephritis.
Doxorubicin-poly (ethylene glycol)-alendronate self-assembled micelles for targeted therapy of bone metastatic cancer.
Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells.
Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth.
Wang L, Zhu H, Shi Z, Chen B, Huang H, Lin G, Li J, Yu H, Xu S, Chen G, Ou R, Dai C
Theranostics 2024;14(1):75-95
Theranostics 2024;14(1):75-95
Isotoosendanin exerts anti-tumor effects in NSCLC by enhancing the stability of SHP-2 and inhibiting the JAK/STAT3 pathway.
Shu C, Chen Y, Wu Z, Zhang W, Zhao J, Wang Y, Zeng Y, Li J, Zhu J, Yan Z, Liu Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155832
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155832
Copper Chaperone Atox1 Protected the Cochlea From Cisplatin by Regulating the Copper Transport Family and Cell Cycle.
Chen X, Xiang W, Li L, Xu K
International journal of toxicology 2024 Mar-Apr;43(2):134-145
International journal of toxicology 2024 Mar-Apr;43(2):134-145
Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice.
Wang P, Kang Q, Wu WS, Rui L
Cell reports 2024 Mar 26;43(3):113875
Cell reports 2024 Mar 26;43(3):113875
ZNF862 induces cytostasis and apoptosis via the p21-RB1 and Bcl-xL-Caspase 3 signaling pathways in human gingival fibroblasts.
Zhu Y, Zhao T, Wu Y, Xie S, Sun W, Wu J
Journal of periodontal research 2024 Jun;59(3):599-610
Journal of periodontal research 2024 Jun;59(3):599-610
The anti-non-small cell lung cancer effect of Diosbulbin B: Targeting YY1 induced cell cycle arrest and apoptosis.
Zhao JQ, Zhou QQ, Sun Y, Yu T, Jiang Y, Li HJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155734
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155734
Combining transcriptomics and network pharmacology to reveal the mechanism of Zuojin capsule improving spasmolytic polypeptide-expressing metaplasia.
Xiong M, Chen X, Wang H, Tang X, Wang Q, Li X, Ma H, Ye X
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117075
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117075
Attenuation of pro-tumorigenic senescent secretory phenotype by StN, a novel derivative of stevioside, potentiates its inhibitory activity on hepatocellular carcinoma.
Guo Y, Wang S, Dong Y, Liu Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114371
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114371
MAPRE3 as an epigenetic target of EZH2 restricts ovarian cancer proliferation in vitro and in vivo.
Zhang Y, Liu F, Zheng J, Jiang K, Ai H, Liu L, Mao D
Experimental cell research 2024 Feb 1;435(1):113913
Experimental cell research 2024 Feb 1;435(1):113913
Dendrobium nobile active ingredient Dendrobin A against hepatocellular carcinoma via inhibiting nuclear factor kappa-B signaling.
Yu Y, Fan Y, Mei W, Xu X, Chen Y, Zhao Y, Ruan B, Shen Z, Lu Y, Zheng S, Jie W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117013
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117013
Liensinine inhibits progression of intrahepatic cholangiocarcinoma by regulating TGF-β1 /P-smad3 signaling through HIF-1a.
Zhu X, Bao W, Xie X, Chen B, Li R, Zhao J, Wu L, Yu Z, Li S, Zhu Q, Chen G, Li J
Molecular carcinogenesis 2024 Apr;63(4):772-784
Molecular carcinogenesis 2024 Apr;63(4):772-784
A novel 2-iminobenzimidazole compound, XYA1353, displays in vitro and in vivo anti-myeloma activity via targeting NF-κB signaling.
Gao J, Zhou J, Zhang M, Zhang Y, Zeng Y, Li S, Xu K, Yao R
Molecular and cellular biochemistry 2024 Apr;479(4):843-857
Molecular and cellular biochemistry 2024 Apr;479(4):843-857
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis.
Bao K, Ma Y, Li Y, Shen X, Zhao J, Tian S, Zhang C, Liang C, Zhao Z, Yang Y, Zhang K, Yang N, Meng FL, Hao J, Yang J, Liu T, Yao Z, Ai D, Shi L
Molecular cell 2024 Apr 4;84(7):1206-1223.e15
Molecular cell 2024 Apr 4;84(7):1206-1223.e15
Sphingolipid metabolism controls mammalian heart regeneration.
Ji X, Chen Z, Wang Q, Li B, Wei Y, Li Y, Lin J, Cheng W, Guo Y, Wu S, Mao L, Xiang Y, Lan T, Gu S, Wei M, Zhang JZ, Jiang L, Wang J, Xu J, Cao N
Cell metabolism 2024 Apr 2;36(4):839-856.e8
Cell metabolism 2024 Apr 2;36(4):839-856.e8
CGRP Released by Corneal Sensory Nerve Maintains Tear Secretion of the Lacrimal Gland.
Ma L, Yang L, Wang X, Zhao L, Bai X, Qi X, Chen Q, Li Y, Zhou Q
Investigative ophthalmology & visual science 2024 Apr 1;65(4):30
Investigative ophthalmology & visual science 2024 Apr 1;65(4):30
GPC3 Promotes Lung Squamous Cell Carcinoma Progression and HLA-A2-Restricted GPC3 Antigenic Peptide-Modified Dendritic Cell-Induced Cytotoxic T Lymphocytes to Kill Lung Squamous Cell Carcinoma Cells.
Ning J, Ding J, Wang S, Jiang Y, Wang D, Jiang S
Journal of immunology research 2023;2023:5532617
Journal of immunology research 2023;2023:5532617
ESRG is critical to maintain the cell survival and self-renewal/pluripotency of hPSCs by collaborating with MCM2 to suppress p53 pathway.
Li S, Liu H, Liu W, Shi N, Zhao M, Wanggou S, Luo W, Wang L, Zhu B, Zuo X, Xie W, Zhao C, Zhou Y, Luo L, Gao X, Jiang X, Ren C
International journal of biological sciences 2023;19(3):916-935
International journal of biological sciences 2023;19(3):916-935
Ebastine exerts antitumor activity and induces autophagy by activating AMPK/ULK1 signaling in an IPMK-dependent manner in osteosarcoma.
Pan Z, Li SJ, Guo H, Li ZH, Fei X, Chang SM, Yang QC, Cheng DD
International journal of biological sciences 2023;19(2):537-551
International journal of biological sciences 2023;19(2):537-551
Phosphofructokinase Platelet Overexpression Accelerated Colorectal Cancer Cell Growth and Motility.
Lu TJ, Yang YF, Cheng CF, Tu YT, Chen YR, Lee MC, Tsai KW
Journal of Cancer 2023;14(6):943-951
Journal of Cancer 2023;14(6):943-951
Inhibition of STAT3 signaling as critical molecular event in HUC-MSCs suppressed Glioblastoma Cells.
Wang M, Zhang Y, Liu M, Jia Y, He J, Xu X, Shi H, Zhang Y, Zhang J, Liu Y
Journal of Cancer 2023;14(4):611-627
Journal of Cancer 2023;14(4):611-627
Reduced FANCE Confers Genomic Instability and Malignant Behavior by Regulating Cell Cycle Progression in Endometrial Cancer.
Zheng C, Ren Z, Chen H, Yuan X, Suye S, Yin H, Fu C
Journal of Cancer 2023;14(14):2670-2685
Journal of Cancer 2023;14(14):2670-2685
Vitamin D3 promotes gastric cancer cell autophagy by mediating p53/AMPK/mTOR signaling.
Wang Y, He Q, Rong K, Zhu M, Zhao X, Zheng P, Mi Y
Frontiers in pharmacology 2023;14:1338260
Frontiers in pharmacology 2023;14:1338260
A Novel Gene Pair CSTF2/DPE2A Impacts Prognosis and Cell Cycle of Hepatocellular Carcinoma.
Huang Y, Xu J, Xie C, Liao Y, Lin R, Zeng Y, Yu F
Journal of hepatocellular carcinoma 2023;10:1639-1657
Journal of hepatocellular carcinoma 2023;10:1639-1657
Nuclear receptor coactivator 6 (NCoA6) promotes cell proliferation, migration, and invasion in pancreatic cancer.
Wang X, Jia Y, Xu X, Hu Y, Fan G, Jing D, Zhang Z, Wang C, Song C, Qin Y, Peng L
Cancer medicine 2023 Sep;12(17):18425-18439
Cancer medicine 2023 Sep;12(17):18425-18439
Tumor-promoting action of ubiquitin protease 43 in gastric cancer progression through deubiquitination and stabilization of stress-inducible phosphoprotein 1.
Guo Z, Guo L
Experimental cell research 2023 Sep 15;430(2):113714
Experimental cell research 2023 Sep 15;430(2):113714
Activation of endoplasmic reticulum stress by harmine suppresses the growth of esophageal squamous cell carcinoma.
Fan R, Wang S, Wu Y, Feng Y, Gao M, Cao Y, Ma X, Xie S, Wang C, Gao L, Wang Y, Dai F
Phytotherapy research : PTR 2023 Oct;37(10):4655-4673
Phytotherapy research : PTR 2023 Oct;37(10):4655-4673
CT2-3 induces cell cycle arrest and apoptosis in rheumatoid arthritis fibroblast-like synoviocytes through regulating PI3K/AKT pathway.
Chen J, Lin X, Liu K, He J, Li X, Zhang C, Deng Y, Luo L, Tao C, Wang Q
European journal of pharmacology 2023 Oct 5;956:175871
European journal of pharmacology 2023 Oct 5;956:175871
Arecoline hydrobromide suppresses PI3K/AKT pathway in rheumatoid arthritis synovial fibroblasts and relieves collagen-induced arthritis in mice.
He J, Lin X, Wang X, Lin T, Lyu S, Gao X, Chen J, Wang Q
International immunopharmacology 2023 Nov;124(Pt B):110925
International immunopharmacology 2023 Nov;124(Pt B):110925
Modulation of cell cycle increases CRISPR-mediated homology-directed DNA repair.
Li G, Yang X, Luo X, Wu Z, Yang H
Cell & bioscience 2023 Nov 25;13(1):215
Cell & bioscience 2023 Nov 25;13(1):215
ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury.
Zhang Y, Fan Y, Hu H, Zhang X, Wang Z, Wu Z, Wang L, Yu X, Song X, Xiang P, Zhang X, Wang T, Tan S, Li C, Gao L, Liang X, Li S, Li N, Yue X, Ma C
Nature communications 2023 Nov 18;14(1):7527
Nature communications 2023 Nov 18;14(1):7527
Angelicin inhibits cell growth and promotes apoptosis in oral squamous cell carcinoma by negatively regulating DUSP6/cMYC signaling pathway.
Liu N, Li C, Shang Q, Qi J, Li Q, Deng J, Dan H, Xie L, Chen Q
Experimental cell research 2023 Nov 15;432(2):113793
Experimental cell research 2023 Nov 15;432(2):113793
Proline-rich 11 (PRR11) promotes the progression of cutaneous squamous cell carcinoma by activating the EGFR signaling pathway.
Wang S, Zhang X, Lei H, Song L, Huang Y, Kang T, Zhang M, Wang N, Yang P, Feng S, Wang J, Bai R, Wang N, Wang W, Zheng Y
Molecular carcinogenesis 2023 May;62(5):613-627
Molecular carcinogenesis 2023 May;62(5):613-627
LMNB1 deletion in ovarian cancer inhibits the proliferation and metastasis of tumor cells through PI3K/Akt pathway.
Dong J, Ru Y, Zhai L, Gao Y, Guo X, Chen B, Lv X
Experimental cell research 2023 May 15;426(2):113573
Experimental cell research 2023 May 15;426(2):113573
An oral phenylacrylic acid derivative suppressed hepatic stellate cell activation and ameliorated liver fibrosis by blocking TGF-β1 signalling.
Xue T, Yue L, Zhu G, Tan Z, Liu H, Gan C, Fan C, Su X, Xie Y, Ye T
Liver international : official journal of the International Association for the Study of the Liver 2023 Mar;43(3):718-732
Liver international : official journal of the International Association for the Study of the Liver 2023 Mar;43(3):718-732
CDCA4 interacts with IGF2BP1 to regulate lung adenocarcinoma proliferation via the PI3K/AKT pathway.
Feng S, Cao H, Sui Y, Shen Z, Wu J, Ma R, Feng J
Thoracic cancer 2023 Mar;14(8):724-735
Thoracic cancer 2023 Mar;14(8):724-735
LIFR recruits HGF-producing neutrophils to promote liver injury repair and regeneration.
Deng Y, Zhao Z, Sheldon M, Zhao Y, Teng H, Martinez C, Zhang J, Lin C, Sun Y, Yao F, Zhu H, Ma L
bioRxiv : the preprint server for biology 2023 Mar 21;
bioRxiv : the preprint server for biology 2023 Mar 21;
Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice.
Chen Y, Chen L, Wu X, Zhao Y, Wang Y, Jiang D, Liu X, Zhou T, Li S, Wei Y, Liu Y, Hu C, Zhou B, Qin J, Ying H, Ding Q
Nature communications 2023 Mar 18;14(1):1521
Nature communications 2023 Mar 18;14(1):1521
Modified Podophyllotoxin Phenoxyacetamide Phenylacetate Derivatives: Tubulin/AKT1 Dual-Targeting and Potential Anticancer Agents for Human NSCLC.
Lin H, Ai D, Liu Q, Wang X, Gao J, Chen Q, Ruan L, Tao Y, Gao J, Wang L
Journal of natural products 2023 Jul 28;86(7):1844-1854
Journal of natural products 2023 Jul 28;86(7):1844-1854
Moringa oleifera Lam. Isothiocyanate Quinazolinone Derivatives Inhibit U251 Glioma Cell Proliferation through Cell Cycle Regulation and Apoptosis Induction.
Xie J, Yang MR, Hu X, Hong ZS, Bai YY, Sheng J, Tian Y, Shi CY
International journal of molecular sciences 2023 Jul 12;24(14)
International journal of molecular sciences 2023 Jul 12;24(14)
Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells.
Wu J, Wang D, Zhou J, Li J, Xie R, Li Y, Huang J, Liu B, Qiu J
Phytotherapy research : PTR 2023 Jan;37(1):310-328
Phytotherapy research : PTR 2023 Jan;37(1):310-328
Identification of a transcription factor‑cyclin family genes network in lung adenocarcinoma through bioinformatics analysis and validation through RT‑qPCR.
Yang X, Zhou Y, Ge H, Tian Z, Li P, Zhao X
Experimental and therapeutic medicine 2023 Jan;25(1):63
Experimental and therapeutic medicine 2023 Jan;25(1):63
Parasympathetic-macrophages-ductal epithelial cells axis promotes female rat submandibular gland regeneration after excretory duct ligation/deligation.
Wang B, Li D, Li J, An W, Li Z, Shao Q, Qin L
Archives of oral biology 2023 Jan;145:105586
Archives of oral biology 2023 Jan;145:105586
CgTNF-2 promotes the proliferation of haemocytes by regulating the expressions of CgRunx and cell cycle related genes in the Pacific oyster Crassostrea gigas.
Wu W, Sun J, Dong M, Yang Q, Yang W, Zhang T, Wang L, Song L
Fish & shellfish immunology 2023 Jan;132:108478
Fish & shellfish immunology 2023 Jan;132:108478
HDAC7/c-Myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cells.
Zhang Y, Ding P, Wang Y, Shao C, Guo K, Yang H, Feng Y, Ning J, Pan M, Wang P, Yan X, Ma Z, Han J
Cell death & disease 2023 Jan 18;14(1):38
Cell death & disease 2023 Jan 18;14(1):38
Revealing active components and action mechanism of Fritillariae Bulbus against non-small cell lung cancer through spectrum-effect relationship and proteomics.
Liu FJ, Chen XY, Yang J, Zhao Z, Wang QL, Li P, Jiang Y, Li HJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154635
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154635
TIM-4 orchestrates mitochondrial homeostasis to promote lung cancer progression via ANXA2/PI3K/AKT/OPA1 axis.
Wang Y, Wang Y, Liu W, Ding L, Zhang X, Wang B, Tong Z, Yue X, Li C, Xu L, Wu Z, Liang X, Ma C, Gao L
Cell death & disease 2023 Feb 20;14(2):141
Cell death & disease 2023 Feb 20;14(2):141
Hypoxia Inhibits Cell Cycle Progression and Cell Proliferation in Brain Microvascular Endothelial Cells via the miR-212-3p/MCM2 Axis.
Shi Q, Li S, Lyu Q, Zhang S, Bai Y, Ma J
International journal of molecular sciences 2023 Feb 1;24(3)
International journal of molecular sciences 2023 Feb 1;24(3)
Dual network analysis of transcriptome data for discovery of new therapeutic targets in non-small cell lung cancer.
Bai Y, Zhou L, Zhang C, Guo M, Xia L, Tang Z, Liu Y, Deng S
Oncogene 2023 Dec;42(49):3605-3618
Oncogene 2023 Dec;42(49):3605-3618
Effects of dietary folic acid supplementation on lactation performance and mammary epithelial cell development of dairy cows and its regulatory mechanism.
Zhang J, Liu YP, Bu LJ, Liu Q, Pei CX, Huo WJ
Animal biotechnology 2023 Dec;34(8):3796-3807
Animal biotechnology 2023 Dec;34(8):3796-3807
Proteomics, Transcriptomics, and Phosphoproteomics Reveal the Mechanism of Talaroconvolutin-A Suppressing Bladder Cancer via Blocking Cell Cycle and Triggering Ferroptosis.
Xia Y, Xiang L, Yao M, Ai Z, Yang W, Guo J, Fan S, Liu N, Yang X
Molecular & cellular proteomics : MCP 2023 Dec;22(12):100672
Molecular & cellular proteomics : MCP 2023 Dec;22(12):100672
Sesamol serves as a p53 stabilizer to relieve rheumatoid arthritis progression and inhibits the growth of synovial organoids.
Lin X, Lin T, Wang X, He J, Gao X, Lyu S, Wang Q, Chen J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155109
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155109
Lnc-PKNOX1-1 inhibits tumor progression in cutaneous malignant melanoma by regulating NF-κB/IL-8 axis.
Hong A, Cao M, Li D, Wang Y, Zhang G, Fang F, Zhao L, Wang Q, Lin T, Wang Y
Carcinogenesis 2023 Dec 30;44(12):871-883
Carcinogenesis 2023 Dec 30;44(12):871-883
Z-Ligustilide Combined with Cisplatin Reduces PLPP1-Mediated Phospholipid Synthesis to Impair Cisplatin Resistance in Lung Cancer.
Geng P, Zhao J, Li Q, Wang X, Qin W, Wang T, Shi X, Liu X, Chen J, Qiu H, Xu G
International journal of molecular sciences 2023 Dec 1;24(23)
International journal of molecular sciences 2023 Dec 1;24(23)
GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1-dependent manner.
Shi M, Hou J, Liang W, Li Q, Shao S, Ci S, Shu C, Zhao X, Zhao S, Huang M, Wu C, Hu Z, He L, Guo Z, Pan F
EMBO reports 2023 Aug 3;24(8):e56437
EMBO reports 2023 Aug 3;24(8):e56437
PHF23 promotes NSCLC proliferation, metastasis, and chemoresistance via stabilization of ACTN4 and activation of the ERK pathway.
Cheng M, Cao H, Yao P, Guan J, Wu P, Ji H, Jiang S, Yuan Y, Fu L, Zheng Q, Li Q
Cell death & disease 2023 Aug 25;14(8):558
Cell death & disease 2023 Aug 25;14(8):558
Low-dose graphene oxide promotes tumor cells proliferation by activating PI3K-AKT-mTOR signaling via cellular membrane protein integrin αV.
Zheng Z, Halifu A, Ma J, Liu L, Fu Q, Yi B, Du E, Tian D, Xu Y, Zhang Z, Zhu J
Environmental pollution (Barking, Essex : 1987) 2023 Aug 1;330:121817
Environmental pollution (Barking, Essex : 1987) 2023 Aug 1;330:121817
The potential mechanism of Neu5Gc inducing colorectal cancer based on network pharmacology and experimental validation.
Zhang LC, Liu YN, La XQ, Yan SN, Chen Y, Liang JY, Li ZY
Naunyn-Schmiedeberg's archives of pharmacology 2023 Apr;396(4):705-718
Naunyn-Schmiedeberg's archives of pharmacology 2023 Apr;396(4):705-718
Prepubertal exposure to copper oxide nanoparticles induces Leydig cell injury with steroidogenesis disorders in mouse testes.
Zheng X, Chen J, Kang L, Wei Y, Wu Y, Hong Y, Wang X, Li D, Shen L, Long C, Wei G, Wu S
Biochemical and biophysical research communications 2023 Apr 30;654:62-72
Biochemical and biophysical research communications 2023 Apr 30;654:62-72
8-Methoxyflindersine-Induced Apoptosis and Cell Cycle Disorder Involving MAPK Signaling Activation in Human Colorectal Cancer Cells.
Zhang D, Fu Y, Liu Y, Wu Y, Chen J, Zhang L, Wang R, Chen Z, Liu T
International journal of molecular sciences 2023 Apr 28;24(9)
International journal of molecular sciences 2023 Apr 28;24(9)
Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells.
Sun YS, Wang ZW, Gao Z, Zhao W, Thakur K, Zhong Q, Wei ZJ
Current research in food science 2022;5:904-917
Current research in food science 2022;5:904-917
Identification and verification of hub genes associated with the progression of non-small cell lung cancer by integrated analysis.
Mengyan X, Kun D, Xinming J, Yutian W, Yongqian S
Frontiers in pharmacology 2022;13:997842
Frontiers in pharmacology 2022;13:997842
KIFC3 Promotes Proliferation, Migration, and Invasion in Colorectal Cancer via PI3K/AKT/mTOR Signaling Pathway.
Liao H, Zhang L, Lu S, Li W, Dong W
Frontiers in genetics 2022;13:848926
Frontiers in genetics 2022;13:848926
Narciclasine inhibits phospholipase A2 and regulates phospholipid metabolism to ameliorate psoriasis-like dermatitis.
Kong Y, Jiang J, Huang Y, Liu X, Jin Z, Li L, Wei F, Liu X, Yin J, Zhang Y, Tong Q, Chen H
Frontiers in immunology 2022;13:1094375
Frontiers in immunology 2022;13:1094375
A long noncoding RNA GTF2IRD2P1 suppresses cell proliferation in bladder cancer by inhibiting the Wnt/β‑catenin signaling pathway.
Huang Z, Gao H, Qing L, Wang B, He C, Luo N, Lu C, Fan S, Gu P, Zhao H
PeerJ 2022;10:e13220
PeerJ 2022;10:e13220
Differentiation Capacity of Bone Marrow-Derived Rat Mesenchymal Stem Cells from DsRed and Cre Transgenic Cre/loxP Models.
Tseng HC, Wu MR, Lee CH, Hsiao JK
Cells 2022 Sep 5;11(17)
Cells 2022 Sep 5;11(17)
A natural halogenated fluoride adenosine analog 5'-fluorodeoxy adenosine induced anticolon cancer activity in vivo and in vitro.
Ma L, Liu T, Lu Y, Dong Y, Zhao X, Man S
Environmental toxicology 2022 Oct;37(10):2493-2502
Environmental toxicology 2022 Oct;37(10):2493-2502
Xanthotoxol suppresses non-small cell lung cancer progression and might improve patients' prognosis.
Lin X, Liu J, Zou Y, Tao C, Chen J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Oct;105:154364
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Oct;105:154364
Radix Glycyrrhizae Preparata Induces Cell Cycle Arrest and Induced Caspase-Dependent Apoptosis in Glioblastoma Multiforme.
Lin TY, Wu TH, Tzou RD, Hsu YC, Lee KT, Tsai TH
Neurology international 2022 Oct 13;14(4):804-823
Neurology international 2022 Oct 13;14(4):804-823
Spindle and kinetochore-associated complex 3 promotes cell growth via the PI3K/AKT/GSK3β and PI3K/AKT/FOXO1 pathways and is a potential prognostic biomarker for oral squamous cell carcinoma.
Xu H, Chen G, Niu Q, Song K, Feng Z, Han Z
Oral surgery, oral medicine, oral pathology and oral radiology 2022 Nov;134(5):599-614
Oral surgery, oral medicine, oral pathology and oral radiology 2022 Nov;134(5):599-614
Porcine Circovirus 2 Activates the PERK-Reactive Oxygen Species Axis To Induce p53 Phosphorylation with Subsequent Cell Cycle Arrest at S Phase in Favor of Its Replication.
Deng Z, Sun R, Han X, Zhang Y, Zhou Y, Shan Y, Xu J, Li X, He F, Fang W
Journal of virology 2022 Nov 23;96(22):e0127422
Journal of virology 2022 Nov 23;96(22):e0127422
WY-14643 attenuates lipid deposition via activation of the PPARα/CPT1A axis by targeting Gly335 to inhibit cell proliferation and migration in ccRCC.
Wang R, Zhao J, Jin J, Tian Y, Lan L, Wang X, Zhu L, Wang J
Lipids in health and disease 2022 Nov 16;21(1):121
Lipids in health and disease 2022 Nov 16;21(1):121
The substitution of SERCA2 redox cysteine 674 promotes pulmonary vascular remodeling by activating IRE1α/XBP1s pathway.
Yu W, Xu G, Chen H, Xiao L, Liu G, Hu P, Li S, Kasim V, Zeng C, Tong X
Acta pharmaceutica Sinica. B 2022 May;12(5):2315-2329
Acta pharmaceutica Sinica. B 2022 May;12(5):2315-2329
Novel dual-targeting c-Myc inhibitor D347-2761 represses myeloma growth via blocking c-Myc/Max heterodimerization and disturbing its stability.
Yao R, Zhang M, Zhou J, Liu L, Zhang Y, Gao J, Xu K
Cell communication and signaling : CCS 2022 May 26;20(1):73
Cell communication and signaling : CCS 2022 May 26;20(1):73
Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells.
Zhang J, Gan Y, Li H, Yin J, He X, Lin L, Xu S, Fang Z, Kim BW, Gao L, Ding L, Zhang E, Ma X, Li J, Li L, Xu Y, Horne D, Xu R, Yu H, Gu Y, Huang W
Nature communications 2022 May 20;13(1):2835
Nature communications 2022 May 20;13(1):2835
Effects of 4-vinylcyclohexene diepoxide on the cell cycle, apoptosis, and steroid hormone secretion of goat ovarian granulosa cells.
Miao Y, Wan W, Zhu K, Pan M, Zhao X, Ma B, Wei Q
In vitro cellular & developmental biology. Animal 2022 Mar;58(3):220-231
In vitro cellular & developmental biology. Animal 2022 Mar;58(3):220-231
Simvastatin Downregulates Cofilin and Stathmin to Inhibit Skeletal Muscle Cells Migration.
Lin LP, Yu TY, Chang HN, Tsai WC, Pang JS
International journal of molecular sciences 2022 Mar 5;23(5)
International journal of molecular sciences 2022 Mar 5;23(5)
ALKBH3-dependent m(1)A demethylation of Aurora A mRNA inhibits ciliogenesis.
Kuang W, Jin H, Yang F, Chen X, Liu J, Li T, Chang Y, Liu M, Xu Z, Huo C, Yan X, Yang Y, Liu W, Shu Q, Xie S, Zhou T
Cell discovery 2022 Mar 11;8(1):25
Cell discovery 2022 Mar 11;8(1):25
MCTS1 promotes laryngeal squamous cell carcinoma cell growth via enhancing LARP7 stability.
Yang M, Ma B, Liu X
Clinical and experimental pharmacology & physiology 2022 Jun;49(6):652-660
Clinical and experimental pharmacology & physiology 2022 Jun;49(6):652-660
CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m(6)A-modified CREB1 mRNA.
Yao B, Zhang Q, Yang Z, An F, Nie H, Wang H, Yang C, Sun J, Chen K, Zhou J, Bai B, Gu S, Zhao W, Zhan Q
Molecular cancer 2022 Jun 30;21(1):140
Molecular cancer 2022 Jun 30;21(1):140
Disruption of mitochondrial redox homeostasis as a mechanism of antimony-induced reactive oxygen species and cytotoxicity.
Su L, Fang W, Zhao X, Zhu L, Gao L, Chen G
Ecotoxicology and environmental safety 2022 Jun 1;237:113519
Ecotoxicology and environmental safety 2022 Jun 1;237:113519
c-myc-mediated upregulation of NAT10 facilitates tumor development via cell cycle regulation in non-small cell lung cancer.
Wang Z, Huang Y, Lu W, Liu J, Li X, Zhu S, Liu H, Song Y
Medical oncology (Northwood, London, England) 2022 Jul 14;39(10):140
Medical oncology (Northwood, London, England) 2022 Jul 14;39(10):140
PTBP3 regulates proliferation of lung squamous cell carcinoma cells via CDC25A-mediated cell cycle progression.
Chen Y, Ji Y, Liu S, Liu Y, Feng W, Jin L
Cancer cell international 2022 Jan 11;22(1):19
Cancer cell international 2022 Jan 11;22(1):19
Anlotinib combined with temozolomide suppresses glioblastoma growth via mediation of JAK2/STAT3 signaling pathway.
Xu P, Wang H, Pan H, Chen J, Deng C
Cancer chemotherapy and pharmacology 2022 Feb;89(2):183-196
Cancer chemotherapy and pharmacology 2022 Feb;89(2):183-196
Cellular communication network factor 1 interlinks autophagy and ERK signaling to promote osteogenesis of periodontal ligament stem cells.
Li Z, Wu Z, Xi X, Zhao F, Liu H, Liu D
Journal of periodontal research 2022 Dec;57(6):1169-1182
Journal of periodontal research 2022 Dec;57(6):1169-1182
Comparative oncology reveals DNMT3B as a molecular vulnerability in undifferentiated pleomorphic sarcoma.
Fuller AM, DeVine A, Murazzi I, Mason NJ, Weber K, Eisinger-Mathason TSK
Cellular oncology (Dordrecht, Netherlands) 2022 Dec;45(6):1277-1295
Cellular oncology (Dordrecht, Netherlands) 2022 Dec;45(6):1277-1295
Artemisitene suppresses rheumatoid arthritis progression via modulating METTL3-mediated N6-methyladenosine modification of ICAM2 mRNA in fibroblast-like synoviocytes.
Chen J, Lin X, He J, Liu D, He L, Zhang M, Luan H, Hu Y, Tao C, Wang Q
Clinical and translational medicine 2022 Dec;12(12):e1148
Clinical and translational medicine 2022 Dec;12(12):e1148
The NF-κB/miR-488/ERBB2 axis modulates pancreatic cancer cell malignancy and tumor growth through cell cycle signaling.
Han D, Zhu S, Li X, Li Z, Huang H, Gao W, Liu Y, Zhu H, Yu X
Cancer biology & therapy 2022 Dec 31;23(1):294-309
Cancer biology & therapy 2022 Dec 31;23(1):294-309
Thymidine Kinase 1 Mediates the Synergistic Antitumor Activity of Ubenimex and Celecoxib via Regulation of Cell Cycle in Colorectal Cancer.
Wang A, Shang Y, Ni J, Wang W, Wang C, Li G, Chen SZ
The Journal of pharmacology and experimental therapeutics 2022 Aug;382(2):188-198
The Journal of pharmacology and experimental therapeutics 2022 Aug;382(2):188-198
Epithelial cells-enriched lncRNA SNHG8 regulates chromatin condensation by binding to Histone H1s.
He P, Zhang C, Ji Y, Ge MK, Yu Y, Zhang N, Yang S, Yu JX, Shen SM, Chen GQ
Cell death and differentiation 2022 Aug;29(8):1569-1581
Cell death and differentiation 2022 Aug;29(8):1569-1581
The Phytochemical Rhein Mediates M(6)A-Independent Suppression of Adipocyte Differentiation.
Huang L, Zhang J, Zhu X, Mi X, Li Q, Gao J, Zhou J, Zhou J, Liu XM
Frontiers in nutrition 2021;8:756803
Frontiers in nutrition 2021;8:756803
The ALDH Family Contributes to Immunocyte Infiltration, Proliferation and Epithelial-Mesenchymal Transformation in Glioma.
Wang Z, Mo Y, Tan Y, Wen Z, Dai Z, Zhang H, Zhang X, Feng S, Liang X, Song T, Cheng Q
Frontiers in immunology 2021;12:756606
Frontiers in immunology 2021;12:756606
Induction of Mitosis Delay and Apoptosis by CDDO-TFEA in Glioblastoma Multiforme.
Tsai TH, Lieu AS, Huang TY, Kwan AL, Lin CL, Hsu YC
Frontiers in pharmacology 2021;12:756228
Frontiers in pharmacology 2021;12:756228
CDCA7 Facilitates Tumor Progression by Directly Regulating CCNA2 Expression in Esophageal Squamous Cell Carcinoma.
Li H, Weng Y, Wang S, Wang F, Wang Y, Kong P, Zhang L, Cheng C, Cui H, Xu E, Wei S, Guo D, Chen F, Bi Y, Meng Y, Cheng X, Cui Y
Frontiers in oncology 2021;11:734655
Frontiers in oncology 2021;11:734655
Potential Role of SWI/SNF Complex Subunit Actin-Like Protein 6A in Cervical Cancer.
Wang Q, Cao Z, Wei Y, Zhang J, Cheng Z
Frontiers in oncology 2021;11:724832
Frontiers in oncology 2021;11:724832
Pinocembrin Inhibits the Proliferation and Metastasis of Breast Cancer via Suppression of the PI3K/AKT Signaling Pathway.
Zhu X, Li R, Wang C, Zhou S, Fan Y, Ma S, Gao D, Gai N, Yang J
Frontiers in oncology 2021;11:661184
Frontiers in oncology 2021;11:661184
RTA404, an Activator of Nrf2, Activates the Checkpoint Kinases and Induces Apoptosis through Intrinsic Apoptotic Pathway in Malignant Glioma.
Tsai TH, Lieu AS, Huang TY, Kwan AL, Lin CL, Hsu YC
Journal of clinical medicine 2021 Oct 20;10(21)
Journal of clinical medicine 2021 Oct 20;10(21)
β-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight.
Hidalgo-Gutiérrez A, Barriocanal-Casado E, Díaz-Casado ME, González-García P, Zenezini Chiozzi R, Acuña-Castroviejo D, López LC
Biomedicines 2021 Oct 13;9(10)
Biomedicines 2021 Oct 13;9(10)
Quantitative differences between cyclin-dependent kinases underlie the unique functions of CDK1 in human cells.
Lau HW, Ma HT, Yeung TK, Tam MY, Zheng D, Chu SK, Poon RYC
Cell reports 2021 Oct 12;37(2):109808
Cell reports 2021 Oct 12;37(2):109808
Identification of a Proteomic Signature of Senescence in Primary Human Mammary Epithelial Cells.
Delfarah A, Hartel NG, Zheng D, Yang J, Graham NA
Journal of proteome research 2021 Nov 5;20(11):5169-5179
Journal of proteome research 2021 Nov 5;20(11):5169-5179
lncRNA SNHG4 modulates colorectal cancer cell cycle and cell proliferation through regulating miR-590-3p/CDK1 axis.
Zhou Z, Tan F, Pei Q, Li C, Zhou Y, Li Y, Pei H
Aging 2021 Mar 19;13(7):9838-9858
Aging 2021 Mar 19;13(7):9838-9858
miR-937-5p targets SOX17 to modulate breast cancer cell cycle and cell proliferation through the Wnt signaling pathway.
Xiong X, Xu W, Gong J, Wang L, Dai M, Chen G, Yuan L
Cellular signalling 2021 Jan;77:109818
Cellular signalling 2021 Jan;77:109818
UHRF1 Knockdown Attenuates Cell Growth, Migration, and Invasion in Cutaneous Squamous Cell Carcinoma.
Li Q, Chu Z, Geng S
Cancer investigation 2021 Jan;39(1):84-97
Cancer investigation 2021 Jan;39(1):84-97
Bioinformatics analysis combined with experiments predicts CENPK as a potential prognostic factor for lung adenocarcinoma.
Ma J, Chen X, Lin M, Wang Z, Wu Y, Li J
Cancer cell international 2021 Jan 21;21(1):65
Cancer cell international 2021 Jan 21;21(1):65
Total saponins from Rhizoma Panacis Majoris inhibit proliferation, induce cell cycle arrest and apoptosis and influence MAPK signalling pathways on the colorectal cancer cell.
Chang L, Zhou R, He Y, Meng M, Hu J, Liu Y, Pan Y, Tang Z, Yue Z
Molecular medicine reports 2021 Aug;24(2)
Molecular medicine reports 2021 Aug;24(2)
SETD4 in the Proliferation, Migration, Angiogenesis, Myogenic Differentiation and Genomic Methylation of Bone Marrow Mesenchymal Stem Cells.
Liao X, Wu C, Shao Z, Zhang S, Zou Y, Wang K, Ha Y, Xing J, Zheng A, Shen Z, Zheng S, Guo J, Jie W
Stem cell reviews and reports 2021 Aug;17(4):1374-1389
Stem cell reviews and reports 2021 Aug;17(4):1374-1389
STAT3-mediated activation of mitochondrial pathway contributes to antitumor effect of dihydrotanshinone I in esophageal squamous cell carcinoma cells.
Qi MM, He PZ, Zhang L, Dong WG
World journal of gastrointestinal oncology 2021 Aug 15;13(8):893-914
World journal of gastrointestinal oncology 2021 Aug 15;13(8):893-914
Silencing of ELK3 Induces S-M Phase Arrest and Apoptosis and Upregulates SERPINE1 Expression Reducing Migration in Prostate Cancer Cells.
Mao Y, Li W, Hua B, Gu X, Pan W, Chen Q, Xu B, Wang Z, Lu C
BioMed research international 2020;2020:2406159
BioMed research international 2020;2020:2406159
Ethanol extract of Ophiorrhiza pumila suppresses liver cancer cell proliferation and migration.
Liu H, Liao W, Fan L, Zheng Z, Liu D, Zhang QW, Yang A, Liu F
Chinese medicine 2020;15:11
Chinese medicine 2020;15:11
Weighted gene co-expression network analysis identifies CCNA2 as a treatment target of prostate cancer through inhibiting cell cycle.
Yang R, Du Y, Wang L, Chen Z, Liu X
Journal of Cancer 2020;11(5):1203-1211
Journal of Cancer 2020;11(5):1203-1211
Ursolic Acid Regulates Cell Cycle and Proliferation in Colon Adenocarcinoma by Suppressing Cyclin B1.
Yang M, Hu C, Cao Y, Liang W, Yang X, Xiao T
Frontiers in pharmacology 2020;11:622212
Frontiers in pharmacology 2020;11:622212
The Long Noncoding RNA LOC441461 (STX17-AS1) Modulates Colorectal Cancer Cell Growth and Motility.
Wang JH, Lu TJ, Kung ML, Yang YF, Yeh CY, Tu YT, Chen WS, Tsai KW
Cancers 2020 Oct 28;12(11)
Cancers 2020 Oct 28;12(11)
A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets.
Watanabe M, Saeki Y, Takahashi H, Ohtake F, Yoshida Y, Kasuga Y, Kondo T, Yaguchi H, Suzuki M, Ishida H, Tanaka K, Hatakeyama S
Communications biology 2020 Oct 20;3(1):592
Communications biology 2020 Oct 20;3(1):592
Mitochondrial UQCC3 Modulates Hypoxia Adaptation by Orchestrating OXPHOS and Glycolysis in Hepatocellular Carcinoma.
Yang Y, Zhang G, Guo F, Li Q, Luo H, Shu Y, Shen Y, Gan J, Xu L, Yang H
Cell reports 2020 Nov 3;33(5):108340
Cell reports 2020 Nov 3;33(5):108340
Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway.
Yuan J, Zhang G, Li X, Ma Q, Cheng W, Wang W, Zhang B, Hu T, Song G
International journal of molecular sciences 2020 Nov 25;21(23)
International journal of molecular sciences 2020 Nov 25;21(23)
EVI5 is an oncogene that regulates the proliferation and metastasis of NSCLC cells.
Cai T, Zhou J, Zeng Y, Du W, Zhang Y, Liu T, Fu Y, Huang JA, Qian Q, Zhu J, Ling C, Liu Z
Journal of experimental & clinical cancer research : CR 2020 May 11;39(1):84
Journal of experimental & clinical cancer research : CR 2020 May 11;39(1):84
AQP1 modulates tendon stem/progenitor cells senescence during tendon aging.
Chen M, Li Y, Xiao L, Dai G, Lu P, Wang Y, Rui Y
Cell death & disease 2020 Mar 18;11(3):193
Cell death & disease 2020 Mar 18;11(3):193
BRCA1 protects cardiac microvascular endothelial cells against irradiation by regulating p21-mediated cell cycle arrest.
Zeng ZM, Du HY, Xiong L, Zeng XL, Zhang P, Cai J, Huang L, Liu AW
Life sciences 2020 Mar 1;244:117342
Life sciences 2020 Mar 1;244:117342
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Tang Q, Ren L, Liu J, Li W, Zheng X, Wang J, Du G
Cell proliferation 2020 Jan;53(1):e12706
Cell proliferation 2020 Jan;53(1):e12706
Blockade of JAK2 protects mice against hypoxia-induced pulmonary arterial hypertension by repressing pulmonary arterial smooth muscle cell proliferation.
Zhang L, Wang Y, Wu G, Rao L, Wei Y, Yue H, Yuan T, Yang P, Xiong F, Zhang S, Zhou Q, Chen Z, Li J, Mo BW, Zhang H, Xiong W, Wang CY
Cell proliferation 2020 Feb;53(2):e12742
Cell proliferation 2020 Feb;53(2):e12742
Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
Liu Y, Zhang M, He T, Yang W, Wang L, Zhang L, Guo M
Clinical epigenetics 2020 Feb 10;12(1):22
Clinical epigenetics 2020 Feb 10;12(1):22
IGFBP6 regulates vascular smooth muscle cell proliferation and morphology via cyclin E-CDK2.
Wang Z, Qi Y, Wang R, Wu W, Li Z, Wang M, Liu R, Zhang C, Li W, Wang S
Journal of cellular physiology 2020 Dec;235(12):9538-9556
Journal of cellular physiology 2020 Dec;235(12):9538-9556
Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway.
Ren S, Xing Y, Wang C, Jiang F, Liu G, Li Z, Jiang T, Zhu Y, Piao D
The international journal of biochemistry & cell biology 2020 Aug;125:105777
The international journal of biochemistry & cell biology 2020 Aug;125:105777
Magnetic targeting enhances the cutaneous wound healing effects of human mesenchymal stem cell-derived iron oxide exosomes.
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Journal of nanobiotechnology 2020 Aug 14;18(1):113
Journal of nanobiotechnology 2020 Aug 14;18(1):113
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Chinese medical journal 2020 Apr 20;133(8):919-928
Chinese medical journal 2020 Apr 20;133(8):919-928
Celastrol attenuates ox-LDL-induced mesangial cell proliferation via suppressing NLRP3 inflammasome activation.
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International journal of biological sciences 2019;15(3):533-543
International journal of biological sciences 2019;15(3):533-543
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PloS one 2019;14(10):e0223232
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OncoTargets and therapy 2019;12:6361-6370
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Pterostilbene, An Active Constituent of Blueberries, Suppresses Proliferation Potential of Human Cholangiocarcinoma via Enhancing the Autophagic Flux.
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Frontiers in pharmacology 2019;10:1238
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MicroRNA-191 promotes hepatocellular carcinoma cell proliferation by has_circ_0000204/miR-191/KLF6 axis.
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Cell proliferation 2019 Sep;52(5):e12635
Cell proliferation 2019 Sep;52(5):e12635
Semaphorin 4C Promotes Macrophage Recruitment and Angiogenesis in Breast Cancer.
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Molecular cancer research : MCR 2019 Oct;17(10):2015-2028
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RANBP9 suppresses tumor proliferation in colorectal cancer.
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Oncology letters 2019 May;17(5):4409-4416
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Lin28 promotes dental pulp cell proliferation via upregulation of cyclin-dependent proteins and interaction with let-7a/IGF2BP2 pathways.
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 May;113:108742
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 May;113:108742
Low C6orf141 Expression is Significantly Associated with a Poor Prognosis in Patients with Oral Cancer.
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Scientific reports 2019 Mar 14;9(1):4520
Scientific reports 2019 Mar 14;9(1):4520
A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network.
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Dual regulatory role of CCNA2 in modulating CDK6 and MET-mediated cell-cycle pathway and EMT progression is blocked by miR-381-3p in bladder cancer.
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):1374-1388
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):1374-1388
Fibroblast growth factor-5 promotes spermatogonial stem cell proliferation via ERK and AKT activation.
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TROAP regulates prostate cancer progression via the WNT3/survivin signalling pathways.
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Metformin Treatment Suppresses Melanoma Cell Growth and Motility Through Modulation of microRNA Expression.
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Cancers 2019 Feb 11;11(2)
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Cell cycle (Georgetown, Tex.) 2018;17(2):225-239
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Journal of virology 2018 Oct 15;92(20)
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Nature communications 2018 Mar 29;9(1):1285
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eLife 2018 Aug 22;7
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Molecular pharmacology 2012 Dec;82(6):1115-28
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HL-60 cells were subjected to SDS PAGE followed by western blot with 18202-1-AP(CCNA2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using CCNA2 antibody 18202-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
