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Learn10493-1-AP
antibody from Proteintech Group
Targeting: TAGLN
DKFZp686P11128, SM22, SMCC, TAGLN1, WS3-10
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ELISAAntibody data
- Antibody Data
- Antigen structure
- References [117]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 10493-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10493-1-AP, RRID:AB_2199363
- Product name
- transgelin/SM22 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated transgelin/SM22 antibody (Cat. #10493-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Insulin-transferrin-selenium promote formation of tissue-engineered vascular grafts in early stage of culture.
TRIM65 promotes vascular smooth muscle cell phenotypic transformation by activating PI3K/Akt/mTOR signaling during atherogenesis.
Knockdown of ARHGAP24 reduces intimal hyperplasia through inhibiting the proliferation and phenotypic switching of smooth muscle cells possibly by inactivating both AKT and ERK1/2 signaling pathways.
Single-cell assessment of primary and stem cell-derived human trophoblast organoids as placenta-modeling platforms.
High estrogen induces trans-differentiation of vascular smooth muscle cells to a macrophage-like phenotype resulting in aortic inflammation via inhibiting VHL/HIF1a/KLF4 axis.
Biphasic regulation of miR-17∼92 transcription during hypoxia: roles of HIF1 and p53 hyperphosphorylation at ser15.
68Ga-FAPI PET imaging monitors response to combined TGF-βR inhibition and immunotherapy in metastatic colorectal cancer.
Quinic acid regulated TMA/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic.
Trimethylamine N-oxide Promotes Atherosclerosis by Regulating Low-Density Lipoprotein-Induced Autophagy in Vascular Smooth Muscle Cells Through PI3K/AKT/mTOR Pathway.
miR-145 Alleviates Smooth Muscle Cell Phenotype Transition via ADAM17-Mediated ACE2 Shedding.
DNMT1 mediates the disturbed flow-induced endothelial to mesenchymal transition through disrupting β-alanine and carnosine homeostasis.
S-propargyl-cysteine promotes the stability of atherosclerotic plaque via maintaining vascular muscle contractile phenotype.
MiR-21-3p in extracellular vesicles from vascular fibroblasts of spontaneously hypertensive rat promotes proliferation and migration of vascular smooth muscle cells.
Clearance of Stress-Induced Premature Senescent Cells Alleviates the Formation of Abdominal Aortic Aneurysms.
Agathis dammara Extract and its Monomer Araucarone Attenuate Abdominal Aortic Aneurysm in Mice.
Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging.
TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease.
Inflachromene inhibits intimal hyperplasia through the HMGB1/2- regulated TLR4-NF-κB pathway.
Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.
A TEMPOL and rapamycin loaded nanofiber-covered stent favors endothelialization and mitigates neointimal hyperplasia and local inflammation.
PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation.
Oleoylethanolamide alleviates hyperlipidaemia-mediated vascular calcification via attenuating mitochondrial DNA stress triggered autophagy-dependent ferroptosis by activating PPARα.
Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15.
CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells.
miR-342-5p promotes vascular smooth muscle cell phenotypic transition through a negative-feedback regulation of Notch signaling via targeting FOXO3.
Exosomes Derived from Endothelial Cells Inhibit Neointimal Hyperplasia Induced by Carotid Artery Injury in Rats via ROS-NLRP3 Inflammasome Pathway.
Fate mapping RNA-sequencing reveal Malat1 regulates Sca1(+) progenitor cells to vascular smooth muscle cells transition in vascular remodeling.
BRG1 is involved in vascular calcification in chronic renal disease via autophagy of vascular smooth muscle cells.
Network pharmacology and experimental analysis to reveal the mechanism of Dan-Shen-Yin against endothelial to mesenchymal transition in atherosclerosis.
Theaflavin-3,3'-Digallate from Black Tea Inhibits Neointima Formation Through Suppression of the PDGFRβ Pathway in Vascular Smooth Muscle Cells.
Stromal Fibroblasts Counteract the Caveolin-1-Dependent Radiation Response of LNCaP Prostate Carcinoma Cells.
Substitution of SERCA2 Cys(674) accelerates aortic aneurysm by inducing endoplasmic reticulum stress and promoting cell apoptosis.
Metabonomics profile analysis in inflammation-induced preterm birth and the potential role of metabolites in regulating premature cervical ripening.
Gut microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation.
Moxifloxacin induces aortic aneurysm and dissection by increasing osteopontin in mice.
The substitution of SERCA2 redox cysteine 674 promotes pulmonary vascular remodeling by activating IRE1α/XBP1s pathway.
miR-335-5p regulates the proliferation, migration and phenotypic switching of vascular smooth muscle cells in aortic dissection by directly regulating SP1.
Kv7.4 channel is a key regulator of vascular inflammation and remodeling in neointimal hyperplasia and abdominal aortic aneurysms.
SIRT6 protects vascular smooth muscle cells from osteogenic transdifferentiation via Runx2 in chronic kidney disease.
Ubiquitin-specific protease 47 is associated with vascular calcification in chronic kidney disease by regulating osteogenic transdifferentiation of vascular smooth muscle cells.
Sclerostin is involved in osteogenic transdifferentiation of vascular smooth muscle cells in chronic kidney disease-associated vascular calcification with non-canonical Wnt signaling.
Defective autophagy triggered by arterial cyclic stretch promotes neointimal hyperplasia in vein grafts via the p62/nrf2/slc7a11 signaling pathway.
Bempedoic acid, an ATP citrate lyase inhibitor, reduces intimal hyperplasia via activation of AMPKα signaling pathway.
Human Placental Endothelial Cell and Trophoblast Heterogeneity and Differentiation Revealed by Single-Cell RNA Sequencing.
Angiogenic factor AGGF1 blocks neointimal formation after vascular injury via interaction with integrin α7 on vascular smooth muscle cells.
Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation.
MED12 Regulates Smooth Muscle Cell Functions and Participates in the Development of Aortic Dissection.
PRDX2 Protects Against Atherosclerosis by Regulating the Phenotype and Function of the Vascular Smooth Muscle Cell.
MicroRNA‑199a‑5p regulates FOXC2 to control human vascular smooth muscle cell phenotypic switch.
Angiotensin II-Induced Long Non-Coding RNA Alivec Regulates Chondrogenesis in Vascular Smooth Muscle Cells.
Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis.
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.
TWIST1 induces phenotypic switching of vascular smooth muscle cells by downregulating p68 and microRNA-143/145.
Compound Danshen Dripping Pill inhibits doxorubicin or isoproterenol-induced cardiotoxicity.
Intermittent short-duration reoxygenation protects against simulated high altitude-induced pulmonary hypertension in rats.
Prostacyclin facilitates vascular smooth muscle cell phenotypic transformation via activating TP receptors when IP receptors are deficient.
Kaposi's sarcoma-associated herpesvirus vFLIP promotes MEndT to generate hybrid M/E state for tumorigenesis.
RETRACTED: The role of ATG-7 contributes to pulmonary hypertension by impacting vascular remodeling.
BGP-15 Inhibits Hyperglycemia-Aggravated VSMC Calcification Induced by High Phosphate.
The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis.
Hydrogen Sulfide Attenuates Aortic Remodeling in Aortic Dissection Associating with Moderated Inflammation and Oxidative Stress through a NO-Dependent Pathway.
MicroRNA-143-5p modulates pulmonary artery smooth muscle cells functions in hypoxic pulmonary hypertension through targeting HIF-1α.
Septin4 Prevents PDGF-BB-induced HAVSMC Phenotypic Transformation, Proliferation and Migration by Promoting SIRT1-STAT3 Deacetylation and Dephosphorylation.
Bioinformatics Analysis Reveals MicroRNA-193a-3p Regulates ACTG2 to Control Phenotype Switch in Human Vascular Smooth Muscle Cells.
Paired box 9 regulates VSMC phenotypic transformation, proliferation, and migration via sonic hedgehog.
CTRP15 derived from cardiac myocytes attenuates TGFβ1-induced fibrotic response in cardiac fibroblasts.
Inhibition of vascular calcification by microRNA-155-5p is accompanied by the inactivation of TGF-β1/Smad2/3 signaling pathway.
miR-137 and its target T-type Ca(V) 3.1 channel modulate dedifferentiation and proliferation of cerebrovascular smooth muscle cells in simulated microgravity rats by regulating calcineurin/NFAT pathway.
T-cell death-associated gene 8 accelerates atherosclerosis by promoting vascular smooth muscle cell proliferation and migration.
Characterization of Burn Eschar Pericytes.
Mapping the Fine-Scale Organization and Plasticity of the Brain Vasculature.
WWP2 regulates SIRT1-STAT3 acetylation and phosphorylation involved in hypertensive angiopathy.
Icotinib Attenuates Monocrotaline-Induced Pulmonary Hypertension by Preventing Pulmonary Arterial Smooth Muscle Cell Dysfunction.
2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes injury-induced vascular neointima formation in mice.
Reticulocalbin 2 enhances osteogenic differentiation of human vascular smooth muscle cells in diabetic conditions.
MicroRNA-122 promotes endothelial cell apoptosis by targeting XIAP: Therapeutic implication for atherosclerosis.
SPARC induces phenotypic modulation of human brain vascular smooth muscle cells via AMPK/mTOR-mediated autophagy.
Transactivation domain of Krüppel-like factor 15 negatively regulates angiotensin II-induced adventitial inflammation and fibrosis.
Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2.
Death-associated protein kinase 3 deficiency alleviates vascular calcification via AMPK-mediated inhibition of endoplasmic reticulum stress.
Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α Inhibits Vascular Calcification Through Sirtuin 3-Mediated Reduction of Mitochondrial Oxidative Stress.
Temporal and spatial changes of peroxiredoxin 2 levels in aortic media at very early stages of atherosclerotic lesion formation in apoE-knockout mice.
Salusin-β Promotes Vascular Calcification via Nicotinamide Adenine Dinucleotide Phosphate/Reactive Oxygen Species-Mediated Klotho Downregulation.
CTRP13 attenuates vascular calcification by regulating Runx2.
Ultramorphological analysis of plaque advancement and cholesterol crystal formation in Ldlr knockout mouse atherosclerosis.
Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors.
Glucagon-Like Peptide-1 Mediates the Protective Effect of the Dipeptidyl Peptidase IV Inhibitor on Renal Fibrosis via Reducing the Phenotypic Conversion of Renal Microvascular Cells in Monocrotaline-Treated Rats.
Teniposide regulates the phenotype switching of vascular smooth muscle cells in a miR-21-dependent manner.
Chicoric acid prevents PDGF-BB-induced VSMC dedifferentiation, proliferation and migration by suppressing ROS/NFκB/mTOR/P70S6K signaling cascade.
Hyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis.
Targeting AGGF1 (angiogenic factor with G patch and FHA domains 1) for Blocking Neointimal Formation After Vascular Injury.
CD98 regulates vascular smooth muscle cell proliferation in atherosclerosis.
Progression-related loss of stromal Caveolin 1 levels fosters the growth of human PC3 xenografts and mediates radiation resistance.
MicroRNA-99a inhibits insulin-induced proliferation, migration, dedifferentiation, and rapamycin resistance of vascular smooth muscle cells by inhibiting insulin-like growth factor-1 receptor and mammalian target of rapamycin.
Vascular smooth muscle cell differentiation from human stem/progenitor cells.
Protein profile screening: reduced expression of Sord in the mouse epididymis induced by nicotine inhibits tyrosine phosphorylation level in capacitated spermatozoa.
C1q/tumor necrosis factor-related protein-6 attenuates post-infarct cardiac fibrosis by targeting RhoA/MRTF-A pathway and inhibiting myofibroblast differentiation.
Expression and significance of NELIN and SM22α in varicose vein tissue.
5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Promotes Phenotypic Switching from Dedifferentiated to Differentiated Phenotype via Reactive Oxygen Species and p38 Mitogen-Activated Protein Kinase in Vascular Smooth Muscle Cells.
MicroRNA 302a is a novel modulator of cholesterol homeostasis and atherosclerosis.
CTRP3 attenuates post-infarct cardiac fibrosis by targeting Smad3 activation and inhibiting myofibroblast differentiation.
Increased Expression of Tissue/Salivary Transgelin mRNA Predicts Poor Prognosis in Patients with Oral Squamous Cell Carcinoma (OSCC).
Identification of colonic fibroblast secretomes reveals secretory factors regulating colon cancer cell proliferation.
Overexpression of c1q/tumor necrosis factor-related protein-3 promotes phosphate-induced vascular smooth muscle cell calcification both in vivo and in vitro.
Transgelin as a therapeutic target to prevent hypoxic pulmonary hypertension.
Transgelin overexpression in lung adenocarcinoma is associated with tumor progression.
Endothelial insulin-like growth factor-1 modulates proliferation and phenotype of smooth muscle cells induced by low shear stress.
Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis.
Adrenomedullin attenuates vascular calcification in fructose-induced insulin resistance rats.
Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer.
Serum-free differentiation of functional human coronary-like vascular smooth muscle cells from embryonic stem cells.
ADAMTS-12 metalloprotease is necessary for normal inflammatory response.
Profiling of differentially expressed proteins in stage IV colorectal cancers with good and poor outcomes.
Directed differentiation of skin-derived precursors into functional vascular smooth muscle cells.
Peptide-mediated disruption of calmodulin-cyclin E interactions inhibits proliferation of vascular smooth muscle cells and neointima formation.
Up-regulation of two actin-associated proteins prompts pulmonary artery smooth muscle cell migration under hypoxia.
Dependence of proliferative vascular smooth muscle cells on CD98hc (4F2hc, SLC3A2).
Sun X, Wang N, Jiang H, Liu Q, Xiao C, Xu J, Wu Y, Mei J, Wu S, Lin Z
Preparative biochemistry & biotechnology 2024 Oct;54(9):1186-1195
Preparative biochemistry & biotechnology 2024 Oct;54(9):1186-1195
TRIM65 promotes vascular smooth muscle cell phenotypic transformation by activating PI3K/Akt/mTOR signaling during atherogenesis.
Zhou ZX, Ma XF, Xiong WH, Ren Z, Jiang M, Deng NH, Zhou BB, Liu HT, Zhou K, Hu HJ, Tang HF, Zheng H, Jiang ZS
Atherosclerosis 2024 Mar;390:117430
Atherosclerosis 2024 Mar;390:117430
Knockdown of ARHGAP24 reduces intimal hyperplasia through inhibiting the proliferation and phenotypic switching of smooth muscle cells possibly by inactivating both AKT and ERK1/2 signaling pathways.
Liu W, Han J, Yang Q, Xia L, Chen C, Song J, Cai Y
Biochemistry and biophysics reports 2024 Mar;37:101591
Biochemistry and biophysics reports 2024 Mar;37:101591
Single-cell assessment of primary and stem cell-derived human trophoblast organoids as placenta-modeling platforms.
Shannon MJ, McNeill GL, Koksal B, Baltayeva J, Wächter J, Castellana B, Peñaherrera MS, Robinson WP, Leung PCK, Beristain AG
Developmental cell 2024 Mar 25;59(6):776-792.e11
Developmental cell 2024 Mar 25;59(6):776-792.e11
High estrogen induces trans-differentiation of vascular smooth muscle cells to a macrophage-like phenotype resulting in aortic inflammation via inhibiting VHL/HIF1a/KLF4 axis.
Zhang R, Wang H, Cheng X, Fan K, Gao T, Qi X, Gao S, Zheng G, Dong H
Aging 2024 Jun 5;16(11):9876-9898
Aging 2024 Jun 5;16(11):9876-9898
Biphasic regulation of miR-17∼92 transcription during hypoxia: roles of HIF1 and p53 hyperphosphorylation at ser15.
Sun MR, Gonzalez S, Huang JB, Zhou Q, Cherukuri A, Adavadkar R, Yan HL, Sun SH, Zhou G, Raj JU, Chen T
American journal of physiology. Lung cellular and molecular physiology 2024 Jul 1;327(1):L102-L113
American journal of physiology. Lung cellular and molecular physiology 2024 Jul 1;327(1):L102-L113
68Ga-FAPI PET imaging monitors response to combined TGF-βR inhibition and immunotherapy in metastatic colorectal cancer.
Li K, Liu W, Yu H, Chen J, Tang W, Wang J, Qi M, Sun Y, Xu X, Zhang J, Li X, Guo W, Li X, Song S, Tang S
The Journal of clinical investigation 2024 Jan 4;134(4)
The Journal of clinical investigation 2024 Jan 4;134(4)
Quinic acid regulated TMA/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic.
Jin Q, Zhang C, Chen R, Jiang L, Li H, Wu P, Li L
Journal of translational medicine 2024 Apr 15;22(1):352
Journal of translational medicine 2024 Apr 15;22(1):352
Trimethylamine N-oxide Promotes Atherosclerosis by Regulating Low-Density Lipoprotein-Induced Autophagy in Vascular Smooth Muscle Cells Through PI3K/AKT/mTOR Pathway.
Shi G, Zeng L, Shi J, Chen Y
International heart journal 2023;64(3):462-469
International heart journal 2023;64(3):462-469
miR-145 Alleviates Smooth Muscle Cell Phenotype Transition via ADAM17-Mediated ACE2 Shedding.
Wen J, Tang B, Guo L, Chen W, Tang X
International journal of hypertension 2023;2023:9497716
International journal of hypertension 2023;2023:9497716
DNMT1 mediates the disturbed flow-induced endothelial to mesenchymal transition through disrupting β-alanine and carnosine homeostasis.
Zhao J, Zhao C, Yang F, Jiang Z, Zhu J, Yao W, Pang W, Zhou J
Theranostics 2023;13(13):4392-4411
Theranostics 2023;13(13):4392-4411
S-propargyl-cysteine promotes the stability of atherosclerotic plaque via maintaining vascular muscle contractile phenotype.
Ping L, Zhi-Ming L, Bi-Shan Z, Lei Z, Bo Y, Yi-Chun Z, Ming-Jie W
Frontiers in cell and developmental biology 2023;11:1291170
Frontiers in cell and developmental biology 2023;11:1291170
MiR-21-3p in extracellular vesicles from vascular fibroblasts of spontaneously hypertensive rat promotes proliferation and migration of vascular smooth muscle cells.
Zheng F, Ye C, Ge R, Wang Y, Tian XL, Chen Q, Li YH, Zhu GQ, Zhou B
Life sciences 2023 Oct 1;330:122023
Life sciences 2023 Oct 1;330:122023
Clearance of Stress-Induced Premature Senescent Cells Alleviates the Formation of Abdominal Aortic Aneurysms.
Xie J, Tang Z, Chen Q, Jia X, Li C, Jin M, Wei G, Zheng H, Li X, Chen Y, Liao W, Liao Y, Bin J, Huang S
Aging and disease 2023 Oct 1;14(5):1778-1798
Aging and disease 2023 Oct 1;14(5):1778-1798
Agathis dammara Extract and its Monomer Araucarone Attenuate Abdominal Aortic Aneurysm in Mice.
Zhang Q, Cai Z, Yu Z, Di C, Qiu Y, Qi R
Cardiovascular drugs and therapy 2023 Nov 18;
Cardiovascular drugs and therapy 2023 Nov 18;
Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging.
Li Y, Huang X, Jin J, Zhang H, Yang K, Han J, Lv Y, Sun Y, Yao C, Lin T, Zhu C, Liu H
Cell & bioscience 2023 May 6;13(1):80
Cell & bioscience 2023 May 6;13(1):80
TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease.
Tang Q, Markby GR, MacNair AJ, Tang K, Tkacz M, Parys M, Phadwal K, MacRae VE, Corcoran BM
Cell proliferation 2023 Jun;56(6):e13435
Cell proliferation 2023 Jun;56(6):e13435
Inflachromene inhibits intimal hyperplasia through the HMGB1/2- regulated TLR4-NF-κB pathway.
Teng S, Zhu Z, Wu C, He Y, Zhou S
International immunopharmacology 2023 Jun;119:110198
International immunopharmacology 2023 Jun;119:110198
Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.
Jiang Q, Lei Z, Wang Z, Wang Q, Zhang Z, Liu X, Xing B, Li S, Guo X, Liu Y, Li X, Qi Y, Shu K, Zhang H, Huang Y, Lei T
Cancers 2023 Jun 27;15(13)
Cancers 2023 Jun 27;15(13)
A TEMPOL and rapamycin loaded nanofiber-covered stent favors endothelialization and mitigates neointimal hyperplasia and local inflammation.
Wang R, Lu J, Yin J, Chen H, Liu H, Xu F, Zang T, Xu R, Li C, Wu Y, Wu Q, Fei X, Zhu M, Shen L, Ge J
Bioactive materials 2023 Jan;19:666-677
Bioactive materials 2023 Jan;19:666-677
PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation.
Peng Z, Tan X, Xie L, Li Z, Zhou S, Li Y
iScience 2023 Jan 20;26(1):105909
iScience 2023 Jan 20;26(1):105909
Oleoylethanolamide alleviates hyperlipidaemia-mediated vascular calcification via attenuating mitochondrial DNA stress triggered autophagy-dependent ferroptosis by activating PPARα.
Chen Z, Sun X, Li X, Liu N
Biochemical pharmacology 2023 Feb;208:115379
Biochemical pharmacology 2023 Feb;208:115379
Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15.
Zhang Q, Du G, Tong L, Guo X, Wei Y
Biochimica et biophysica acta. Molecular basis of disease 2023 Dec;1869(8):166805
Biochimica et biophysica acta. Molecular basis of disease 2023 Dec;1869(8):166805
CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells.
Yu W, Zhang Q, Qiu Y, Chen H, Huang X, Xiao L, Xu G, Li S, Hu P, Tong X
Clinical and experimental hypertension (New York, N.Y. : 1993) 2023 Dec 31;45(1):2272062
Clinical and experimental hypertension (New York, N.Y. : 1993) 2023 Dec 31;45(1):2272062
miR-342-5p promotes vascular smooth muscle cell phenotypic transition through a negative-feedback regulation of Notch signaling via targeting FOXO3.
Wen T, Duan Y, Gao D, Zhang X, Zhang X, Liang L, Yang Z, Zhang P, Zhang J, Sun J, Feng Y, Zheng Q, Han H, Yan X
Life sciences 2023 Aug 1;326:121828
Life sciences 2023 Aug 1;326:121828
Exosomes Derived from Endothelial Cells Inhibit Neointimal Hyperplasia Induced by Carotid Artery Injury in Rats via ROS-NLRP3 Inflammasome Pathway.
Yang SY, Deng WW, Zhao RZ, Long XP, Wang DM, Guo HH, Jiang LX, Chen WM, Shi B
Bulletin of experimental biology and medicine 2023 Apr;174(6):762-767
Bulletin of experimental biology and medicine 2023 Apr;174(6):762-767
Fate mapping RNA-sequencing reveal Malat1 regulates Sca1(+) progenitor cells to vascular smooth muscle cells transition in vascular remodeling.
Lyu L, Li Z, Wen Z, He Y, Wang X, Jiang L, Zhou X, Huang C, Wu Y, Chen T, Guo X
Cellular and molecular life sciences : CMLS 2023 Apr 6;80(5):118
Cellular and molecular life sciences : CMLS 2023 Apr 6;80(5):118
BRG1 is involved in vascular calcification in chronic renal disease via autophagy of vascular smooth muscle cells.
Feng Y, Yu M, Wang C, Xia J, Huang L, Tang Y, Xiao Q, Pu L, Wang L, Li G, Li Y
iScience 2023 Apr 21;26(4):106485
iScience 2023 Apr 21;26(4):106485
Network pharmacology and experimental analysis to reveal the mechanism of Dan-Shen-Yin against endothelial to mesenchymal transition in atherosclerosis.
Hong M, Wu Y, Zhang H, Gu J, Chen J, Guan Y, Qin X, Li Y, Cao J
Frontiers in pharmacology 2022;13:946193
Frontiers in pharmacology 2022;13:946193
Theaflavin-3,3'-Digallate from Black Tea Inhibits Neointima Formation Through Suppression of the PDGFRβ Pathway in Vascular Smooth Muscle Cells.
Wu Y, Chen M, Chen Z, Shu J, Zhang L, Hu J, Yu H, Huang K, Liang M
Frontiers in pharmacology 2022;13:861319
Frontiers in pharmacology 2022;13:861319
Stromal Fibroblasts Counteract the Caveolin-1-Dependent Radiation Response of LNCaP Prostate Carcinoma Cells.
Wittka A, Ketteler J, Borgards L, Maier P, Herskind C, Jendrossek V, Klein D
Frontiers in oncology 2022;12:802482
Frontiers in oncology 2022;12:802482
Substitution of SERCA2 Cys(674) accelerates aortic aneurysm by inducing endoplasmic reticulum stress and promoting cell apoptosis.
Wang L, Yang Z, Wang S, Que Y, Shu X, Wu F, Liu G, Li S, Hu P, Chen H, Shi J, Tong X
British journal of pharmacology 2022 Sep;179(17):4423-4439
British journal of pharmacology 2022 Sep;179(17):4423-4439
Metabonomics profile analysis in inflammation-induced preterm birth and the potential role of metabolites in regulating premature cervical ripening.
Yan Y, Gu Z, Li B, Guo X, Zhang Z, Zhang R, Bian Z, Qiu J
Reproductive biology and endocrinology : RB&E 2022 Sep 6;20(1):135
Reproductive biology and endocrinology : RB&E 2022 Sep 6;20(1):135
Gut microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation.
Tian Z, Zhang Y, Zheng Z, Zhang M, Zhang T, Jin J, Zhang X, Yao G, Kong D, Zhang C, Wang Z, Zhang Q
Cell host & microbe 2022 Oct 12;30(10):1450-1463.e8
Cell host & microbe 2022 Oct 12;30(10):1450-1463.e8
Moxifloxacin induces aortic aneurysm and dissection by increasing osteopontin in mice.
Inada K, Koga M, Yamada A, Dohgu S, Yamauchi A
Biochemical and biophysical research communications 2022 Nov 12;629:1-5
Biochemical and biophysical research communications 2022 Nov 12;629:1-5
The substitution of SERCA2 redox cysteine 674 promotes pulmonary vascular remodeling by activating IRE1α/XBP1s pathway.
Yu W, Xu G, Chen H, Xiao L, Liu G, Hu P, Li S, Kasim V, Zeng C, Tong X
Acta pharmaceutica Sinica. B 2022 May;12(5):2315-2329
Acta pharmaceutica Sinica. B 2022 May;12(5):2315-2329
miR-335-5p regulates the proliferation, migration and phenotypic switching of vascular smooth muscle cells in aortic dissection by directly regulating SP1.
Ma R, Zhang D, Song Y, Kong J, Mu C, Shen P, Gui W
Acta biochimica et biophysica Sinica 2022 Jul 25;54(7):961-973
Acta biochimica et biophysica Sinica 2022 Jul 25;54(7):961-973
Kv7.4 channel is a key regulator of vascular inflammation and remodeling in neointimal hyperplasia and abdominal aortic aneurysms.
Fan XZ, Wang YY, Cui ZY, Cheng ZH, Zhang HL, Gamper N, Zhang F, Han M
Free radical biology & medicine 2022 Jan;178:111-124
Free radical biology & medicine 2022 Jan;178:111-124
SIRT6 protects vascular smooth muscle cells from osteogenic transdifferentiation via Runx2 in chronic kidney disease.
Li W, Feng W, Su X, Luo D, Li Z, Zhou Y, Zhu Y, Zhang M, Chen J, Liu B, Huang H
The Journal of clinical investigation 2022 Jan 4;132(1)
The Journal of clinical investigation 2022 Jan 4;132(1)
Ubiquitin-specific protease 47 is associated with vascular calcification in chronic kidney disease by regulating osteogenic transdifferentiation of vascular smooth muscle cells.
Xiao Q, Tang Y, Xia J, Luo H, Yu M, Chen S, Wang W, Pu L, Wang L, Li G, Li Y
Renal failure 2022 Dec;44(1):752-766
Renal failure 2022 Dec;44(1):752-766
Sclerostin is involved in osteogenic transdifferentiation of vascular smooth muscle cells in chronic kidney disease-associated vascular calcification with non-canonical Wnt signaling.
Xiao Q, Tang Y, Luo H, Chen S, Chen R, Yan Z, Pu L, Wang L, Li G, Li Y
Renal failure 2022 Dec;44(1):1426-1442
Renal failure 2022 Dec;44(1):1426-1442
Defective autophagy triggered by arterial cyclic stretch promotes neointimal hyperplasia in vein grafts via the p62/nrf2/slc7a11 signaling pathway.
Chen Y, Bao M, Liu JT, Bao H, Zhang SM, Lou Y, Qi YX
Journal of molecular and cellular cardiology 2022 Dec;173:101-114
Journal of molecular and cellular cardiology 2022 Dec;173:101-114
Bempedoic acid, an ATP citrate lyase inhibitor, reduces intimal hyperplasia via activation of AMPKα signaling pathway.
Liu W, Liu M, Xiong H, Xia L, Yang Q, Chen M, Cai Y, Li S
International immunopharmacology 2022 Dec;113(Pt A):109392
International immunopharmacology 2022 Dec;113(Pt A):109392
Human Placental Endothelial Cell and Trophoblast Heterogeneity and Differentiation Revealed by Single-Cell RNA Sequencing.
Li H, Peng H, Hong W, Wei Y, Tian H, Huang X, Jia L, Zheng J, Duan T, He Q, Wang K
Cells 2022 Dec 25;12(1)
Cells 2022 Dec 25;12(1)
Angiogenic factor AGGF1 blocks neointimal formation after vascular injury via interaction with integrin α7 on vascular smooth muscle cells.
Yu Y, Li Y, Peng H, Song Q, Da X, Li H, He Z, Ren X, Xu C, Yao Y, Wang QK
The Journal of biological chemistry 2022 Apr;298(4):101759
The Journal of biological chemistry 2022 Apr;298(4):101759
Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation.
Zhong L, Yao L, Holdreith N, Yu W, Gui T, Miao Z, Elkaim Y, Li M, Gong Y, Pacifici M, Maity A, Busch TM, Joeng KS, Cengel K, Seale P, Tong W, Qin L
JCI insight 2022 Apr 8;7(7)
JCI insight 2022 Apr 8;7(7)
MED12 Regulates Smooth Muscle Cell Functions and Participates in the Development of Aortic Dissection.
Zhou Y, Zha L, Wu J, Wang M, Zhou M, Wu G, Cheng X, Huang Z, Xie Q, Tu X
Genes 2022 Apr 14;13(4)
Genes 2022 Apr 14;13(4)
PRDX2 Protects Against Atherosclerosis by Regulating the Phenotype and Function of the Vascular Smooth Muscle Cell.
Li J, Wang C, Wang W, Liu L, Zhang Q, Zhang J, Wang B, Wang S, Hou L, Gao C, Yu X, Sun L
Frontiers in cardiovascular medicine 2021;8:624796
Frontiers in cardiovascular medicine 2021;8:624796
MicroRNA‑199a‑5p regulates FOXC2 to control human vascular smooth muscle cell phenotypic switch.
Cao Y, Cao Z, Wang W, Jie X, Li L
Molecular medicine reports 2021 Sep;24(3)
Molecular medicine reports 2021 Sep;24(3)
Angiotensin II-Induced Long Non-Coding RNA Alivec Regulates Chondrogenesis in Vascular Smooth Muscle Cells.
Samara VA, Das S, Reddy MA, Tanwar VS, Stapleton K, Leung A, Abdollahi M, Ganguly R, Lanting L, Natarajan R
Cells 2021 Oct 9;10(10)
Cells 2021 Oct 9;10(10)
Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis.
Li Z, Li Q, Wang L, Li C, Xu M, Duan Y, Ma L, Li T, Chen Q, Wang Y, Wang Y, Feng J, Yin X, Wang X, Han J, Lu C
Redox biology 2021 Nov;47:102156
Redox biology 2021 Nov;47:102156
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.
Ma WQ, Sun XJ, Zhu Y, Liu NF
Free radical biology & medicine 2021 Mar;165:229-242
Free radical biology & medicine 2021 Mar;165:229-242
TWIST1 induces phenotypic switching of vascular smooth muscle cells by downregulating p68 and microRNA-143/145.
Zhang J, Guo JR, Wu XL, Wang X, Zhu ZM, Wang Y, Gu X, Fan Y
FEBS open bio 2021 Mar;11(3):932-943
FEBS open bio 2021 Mar;11(3):932-943
Compound Danshen Dripping Pill inhibits doxorubicin or isoproterenol-induced cardiotoxicity.
Feng K, Liu Y, Sun J, Zhao C, Duan Y, Wang W, Yan K, Yan X, Sun H, Hu Y, Han J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111531
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111531
Intermittent short-duration reoxygenation protects against simulated high altitude-induced pulmonary hypertension in rats.
Lyu Q, Bai Y, Cheng J, Liu H, Li S, Yang J, Wang Z, Ma Y, Jiang M, Dong D, Yan Y, Shi Q, Ren X, Ma J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21212
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21212
Prostacyclin facilitates vascular smooth muscle cell phenotypic transformation via activating TP receptors when IP receptors are deficient.
Li Z, Luo W, Fang S, Chen X, Lin T, Zhou S, Zhang L, Yang W, Li Z, Ye J, Wang J, Liu P, Li Z
Acta physiologica (Oxford, England) 2021 Feb;231(2):e13555
Acta physiologica (Oxford, England) 2021 Feb;231(2):e13555
Kaposi's sarcoma-associated herpesvirus vFLIP promotes MEndT to generate hybrid M/E state for tumorigenesis.
Chen W, Ding Y, Liu D, Lu Z, Wang Y, Yuan Y
PLoS pathogens 2021 Dec;17(12):e1009600
PLoS pathogens 2021 Dec;17(12):e1009600
RETRACTED: The role of ATG-7 contributes to pulmonary hypertension by impacting vascular remodeling.
Yang X, Zhang L, Ye JQ, Wu XH, Zeng XX, Chen LW, Li YM
Journal of molecular and cellular cardiology 2021 Aug;157:1-13
Journal of molecular and cellular cardiology 2021 Aug;157:1-13
BGP-15 Inhibits Hyperglycemia-Aggravated VSMC Calcification Induced by High Phosphate.
Nagy A, Pethő D, Gesztelyi R, Juhász B, Balla G, Szilvássy Z, Balla J, Gáll T
International journal of molecular sciences 2021 Aug 26;22(17)
International journal of molecular sciences 2021 Aug 26;22(17)
The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis.
Pi S, Mao L, Chen J, Shi H, Liu Y, Guo X, Li Y, Zhou L, He H, Yu C, Liu J, Dang Y, Xia Y, He Q, Jin H, Li Y, Hu Y, Miao Y, Yue Z, Hu B
Autophagy 2021 Apr;17(4):980-1000
Autophagy 2021 Apr;17(4):980-1000
Hydrogen Sulfide Attenuates Aortic Remodeling in Aortic Dissection Associating with Moderated Inflammation and Oxidative Stress through a NO-Dependent Pathway.
Lu HY, Hsu HL, Li CH, Li SJ, Lin SJ, Shih CM, Shih CC
Antioxidants (Basel, Switzerland) 2021 Apr 27;10(5)
Antioxidants (Basel, Switzerland) 2021 Apr 27;10(5)
MicroRNA-143-5p modulates pulmonary artery smooth muscle cells functions in hypoxic pulmonary hypertension through targeting HIF-1α.
Tang BI, Tang MM, Xu QM, Guo JL, Xuan L, Zhou J, Wang XJ, Zhang H, Kang PF
Journal of biosciences 2020;45
Journal of biosciences 2020;45
Septin4 Prevents PDGF-BB-induced HAVSMC Phenotypic Transformation, Proliferation and Migration by Promoting SIRT1-STAT3 Deacetylation and Dephosphorylation.
Zhang N, Zhang Y, You S, Tian Y, Lu S, Cao L, Sun Y
International journal of biological sciences 2020;16(4):708-718
International journal of biological sciences 2020;16(4):708-718
Bioinformatics Analysis Reveals MicroRNA-193a-3p Regulates ACTG2 to Control Phenotype Switch in Human Vascular Smooth Muscle Cells.
Wang W, Wang Y, Piao H, Li B, Zhu Z, Li D, Wang T, Liu K
Frontiers in genetics 2020;11:572707
Frontiers in genetics 2020;11:572707
Paired box 9 regulates VSMC phenotypic transformation, proliferation, and migration via sonic hedgehog.
Xu J, Zhang Y, You S, Guo Y, Chen S, Chang Y, Zhang N, Sun Y
Life sciences 2020 Sep 15;257:118053
Life sciences 2020 Sep 15;257:118053
CTRP15 derived from cardiac myocytes attenuates TGFβ1-induced fibrotic response in cardiac fibroblasts.
Zhao Q, Zhang CL, Xiang RL, Wu LL, Li L
Cardiovascular drugs and therapy 2020 Oct;34(5):591-604
Cardiovascular drugs and therapy 2020 Oct;34(5):591-604
Inhibition of vascular calcification by microRNA-155-5p is accompanied by the inactivation of TGF-β1/Smad2/3 signaling pathway.
Zhao F, Wu Y, Yang W, Wu D, Wang C, Zhang F
Acta histochemica 2020 May;122(4):151551
Acta histochemica 2020 May;122(4):151551
miR-137 and its target T-type Ca(V) 3.1 channel modulate dedifferentiation and proliferation of cerebrovascular smooth muscle cells in simulated microgravity rats by regulating calcineurin/NFAT pathway.
Zhang B, Chen L, Bai YG, Song JB, Cheng JH, Ma HZ, Ma J, Xie MJ
Cell proliferation 2020 Mar;53(3):e12774
Cell proliferation 2020 Mar;53(3):e12774
T-cell death-associated gene 8 accelerates atherosclerosis by promoting vascular smooth muscle cell proliferation and migration.
Chen LD, Zhu WT, Cheng YY, Li ZH, Chen YQ, Yuan ZW, Lin CY, Jing DD, Liu ZQ, Yan PK
Atherosclerosis 2020 Mar;297:64-73
Atherosclerosis 2020 Mar;297:64-73
Characterization of Burn Eschar Pericytes.
Evdokiou A, Kanisicak O, Gierek S, Barry A, Ivey MJ, Zhang X, Bodnar RJ, Satish L
Journal of clinical medicine 2020 Feb 24;9(2)
Journal of clinical medicine 2020 Feb 24;9(2)
Mapping the Fine-Scale Organization and Plasticity of the Brain Vasculature.
Kirst C, Skriabine S, Vieites-Prado A, Topilko T, Bertin P, Gerschenfeld G, Verny F, Topilko P, Michalski N, Tessier-Lavigne M, Renier N
Cell 2020 Feb 20;180(4):780-795.e25
Cell 2020 Feb 20;180(4):780-795.e25
WWP2 regulates SIRT1-STAT3 acetylation and phosphorylation involved in hypertensive angiopathy.
Zhang Y, You S, Tian Y, Lu S, Cao L, Sun Y, Zhang N
Journal of cellular and molecular medicine 2020 Aug;24(16):9041-9054
Journal of cellular and molecular medicine 2020 Aug;24(16):9041-9054
Icotinib Attenuates Monocrotaline-Induced Pulmonary Hypertension by Preventing Pulmonary Arterial Smooth Muscle Cell Dysfunction.
Peng LY, Yu M, Yang MX, Liu P, Zhou H, Huang W, Kong H, Xie WP
American journal of hypertension 2020 Aug 4;33(8):775-783
American journal of hypertension 2020 Aug 4;33(8):775-783
2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes injury-induced vascular neointima formation in mice.
Guo S, Zhang R, Liu Q, Wan Q, Wang Y, Yu Y, Liu G, Shen Y, Yu Y, Zhang J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10207-10217
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10207-10217
Reticulocalbin 2 enhances osteogenic differentiation of human vascular smooth muscle cells in diabetic conditions.
Chang Z, Yan G, Yan H, Zheng J, Liu Z
Life sciences 2019 Sep 15;233:116746
Life sciences 2019 Sep 15;233:116746
MicroRNA-122 promotes endothelial cell apoptosis by targeting XIAP: Therapeutic implication for atherosclerosis.
Li Y, Yang N, Dong B, Yang J, Kou L, Qin Q
Life sciences 2019 Sep 1;232:116590
Life sciences 2019 Sep 1;232:116590
SPARC induces phenotypic modulation of human brain vascular smooth muscle cells via AMPK/mTOR-mediated autophagy.
Li T, Tan X, Zhu S, Zhong W, Huang B, Sun J, Li F, Wang Y
Neuroscience letters 2019 Nov 1;712:134485
Neuroscience letters 2019 Nov 1;712:134485
Transactivation domain of Krüppel-like factor 15 negatively regulates angiotensin II-induced adventitial inflammation and fibrosis.
Lu YY, Li XD, Zhou HD, Shao S, He S, Hong MN, Liu JC, Xu YL, Wu YJ, Zhu DL, Wang JG, Gao PJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):6254-6268
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):6254-6268
Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2.
Wang C, Xu W, An J, Liang M, Li Y, Zhang F, Tong Q, Huang K
Nature communications 2019 Mar 13;10(1):1203
Nature communications 2019 Mar 13;10(1):1203
Death-associated protein kinase 3 deficiency alleviates vascular calcification via AMPK-mediated inhibition of endoplasmic reticulum stress.
Li KX, Du Q, Wang HP, Sun HJ
European journal of pharmacology 2019 Jun 5;852:90-98
European journal of pharmacology 2019 Jun 5;852:90-98
Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α Inhibits Vascular Calcification Through Sirtuin 3-Mediated Reduction of Mitochondrial Oxidative Stress.
Feng H, Wang JY, Yu B, Cong X, Zhang WG, Li L, Liu LM, Zhou Y, Zhang CL, Gu PL, Wu LL
Antioxidants & redox signaling 2019 Jul 1;31(1):75-91
Antioxidants & redox signaling 2019 Jul 1;31(1):75-91
Temporal and spatial changes of peroxiredoxin 2 levels in aortic media at very early stages of atherosclerotic lesion formation in apoE-knockout mice.
Kato R, Hayashi M, Aiuchi T, Sawada N, Obama T, Itabe H
Free radical biology & medicine 2019 Jan;130:348-360
Free radical biology & medicine 2019 Jan;130:348-360
Salusin-β Promotes Vascular Calcification via Nicotinamide Adenine Dinucleotide Phosphate/Reactive Oxygen Species-Mediated Klotho Downregulation.
Sun H, Zhang F, Xu Y, Sun S, Wang H, Du Q, Gu C, Black SM, Han Y, Tang H
Antioxidants & redox signaling 2019 Dec 20;31(18):1352-1370
Antioxidants & redox signaling 2019 Dec 20;31(18):1352-1370
CTRP13 attenuates vascular calcification by regulating Runx2.
Li Y, Wang W, Chao Y, Zhang F, Wang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Aug;33(8):9627-9637
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Aug;33(8):9627-9637
Ultramorphological analysis of plaque advancement and cholesterol crystal formation in Ldlr knockout mouse atherosclerosis.
Baumer Y, McCurdy S, Jin X, Weatherby TM, Dey AK, Mehta NN, Yap JK, Kruth HS, Boisvert WA
Atherosclerosis 2019 Aug;287:100-111
Atherosclerosis 2019 Aug;287:100-111
Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors.
Huang YY, Yu YF, Zhang C, Chen Y, Zhou Q, Li Z, Zhou S, Li Z, Guo L, Wu D, Wu Y, Luo HB
Journal of medicinal chemistry 2019 Apr 11;62(7):3707-3721
Journal of medicinal chemistry 2019 Apr 11;62(7):3707-3721
Glucagon-Like Peptide-1 Mediates the Protective Effect of the Dipeptidyl Peptidase IV Inhibitor on Renal Fibrosis via Reducing the Phenotypic Conversion of Renal Microvascular Cells in Monocrotaline-Treated Rats.
Xu J, Wang J, Cheng Y, Li X, He M, Zhu J, Han H, Wei G, Kong H, Xie W, Wang H, Zuo X
BioMed research international 2018;2018:1864107
BioMed research international 2018;2018:1864107
Teniposide regulates the phenotype switching of vascular smooth muscle cells in a miR-21-dependent manner.
Han H, Yang S, Liang Y, Zeng P, Liu L, Yang X, Duan Y, Han J, Chen Y
Biochemical and biophysical research communications 2018 Dec 2;506(4):1040-1046
Biochemical and biophysical research communications 2018 Dec 2;506(4):1040-1046
Chicoric acid prevents PDGF-BB-induced VSMC dedifferentiation, proliferation and migration by suppressing ROS/NFκB/mTOR/P70S6K signaling cascade.
Lu QB, Wan MY, Wang PY, Zhang CX, Xu DY, Liao X, Sun HJ
Redox biology 2018 Apr;14:656-668
Redox biology 2018 Apr;14:656-668
Hyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis.
Baumer Y, McCurdy S, Weatherby TM, Mehta NN, Halbherr S, Halbherr P, Yamazaki N, Boisvert WA
Nature communications 2017 Oct 24;8(1):1129
Nature communications 2017 Oct 24;8(1):1129
Targeting AGGF1 (angiogenic factor with G patch and FHA domains 1) for Blocking Neointimal Formation After Vascular Injury.
Yao Y, Hu Z, Ye J, Hu C, Song Q, Da X, Yu Y, Li H, Xu C, Chen Q, Wang QK
Journal of the American Heart Association 2017 Jun 25;6(6)
Journal of the American Heart Association 2017 Jun 25;6(6)
CD98 regulates vascular smooth muscle cell proliferation in atherosclerosis.
Baumer Y, McCurdy S, Alcala M, Mehta N, Lee BH, Ginsberg MH, Boisvert WA
Atherosclerosis 2017 Jan;256:105-114
Atherosclerosis 2017 Jan;256:105-114
Progression-related loss of stromal Caveolin 1 levels fosters the growth of human PC3 xenografts and mediates radiation resistance.
Panic A, Ketteler J, Reis H, Sak A, Herskind C, Maier P, Rübben H, Jendrossek V, Klein D
Scientific reports 2017 Jan 23;7:41138
Scientific reports 2017 Jan 23;7:41138
MicroRNA-99a inhibits insulin-induced proliferation, migration, dedifferentiation, and rapamycin resistance of vascular smooth muscle cells by inhibiting insulin-like growth factor-1 receptor and mammalian target of rapamycin.
Zhang ZW, Guo RW, Lv JL, Wang XM, Ye JS, Lu NH, Liang X, Yang LX
Biochemical and biophysical research communications 2017 Apr 29;486(2):414-422
Biochemical and biophysical research communications 2017 Apr 29;486(2):414-422
Vascular smooth muscle cell differentiation from human stem/progenitor cells.
Steinbach SK, Husain M
Methods (San Diego, Calif.) 2016 May 15;101:85-92
Methods (San Diego, Calif.) 2016 May 15;101:85-92
Protein profile screening: reduced expression of Sord in the mouse epididymis induced by nicotine inhibits tyrosine phosphorylation level in capacitated spermatozoa.
Dai J, Xu W, Zhao X, Zhang M, Zhang D, Nie D, Bao M, Wang Z, Wang L, Qiao Z
Reproduction (Cambridge, England) 2016 Mar;151(3):227-37
Reproduction (Cambridge, England) 2016 Mar;151(3):227-37
C1q/tumor necrosis factor-related protein-6 attenuates post-infarct cardiac fibrosis by targeting RhoA/MRTF-A pathway and inhibiting myofibroblast differentiation.
Lei H, Wu D, Wang JY, Li L, Zhang CL, Feng H, Fu FY, Wu LL
Basic research in cardiology 2015;110(4):35
Basic research in cardiology 2015;110(4):35
Expression and significance of NELIN and SM22α in varicose vein tissue.
Chen S, Qin S, Wang M, Zhang S
Experimental and therapeutic medicine 2015 Mar;9(3):845-849
Experimental and therapeutic medicine 2015 Mar;9(3):845-849
5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Promotes Phenotypic Switching from Dedifferentiated to Differentiated Phenotype via Reactive Oxygen Species and p38 Mitogen-Activated Protein Kinase in Vascular Smooth Muscle Cells.
Dan J, Sun X, Li W, Zhang Y, Li X, Xu H, Li Z, Tian Z, Guo S, Yao J, Gao W, Tian Y
Ultrasound in medicine & biology 2015 Jun;41(6):1681-9
Ultrasound in medicine & biology 2015 Jun;41(6):1681-9
MicroRNA 302a is a novel modulator of cholesterol homeostasis and atherosclerosis.
Meiler S, Baumer Y, Toulmin E, Seng K, Boisvert WA
Arteriosclerosis, thrombosis, and vascular biology 2015 Feb;35(2):323-31
Arteriosclerosis, thrombosis, and vascular biology 2015 Feb;35(2):323-31
CTRP3 attenuates post-infarct cardiac fibrosis by targeting Smad3 activation and inhibiting myofibroblast differentiation.
Wu D, Lei H, Wang JY, Zhang CL, Feng H, Fu FY, Li L, Wu LL
Journal of molecular medicine (Berlin, Germany) 2015 Dec;93(12):1311-25
Journal of molecular medicine (Berlin, Germany) 2015 Dec;93(12):1311-25
Increased Expression of Tissue/Salivary Transgelin mRNA Predicts Poor Prognosis in Patients with Oral Squamous Cell Carcinoma (OSCC).
Bu J, Bu X, Liu B, Chen F, Chen P
Medical science monitor : international medical journal of experimental and clinical research 2015 Aug 5;21:2275-81
Medical science monitor : international medical journal of experimental and clinical research 2015 Aug 5;21:2275-81
Identification of colonic fibroblast secretomes reveals secretory factors regulating colon cancer cell proliferation.
Chen SX, Xu XE, Wang XQ, Cui SJ, Xu LL, Jiang YH, Zhang Y, Yan HB, Zhang Q, Qiao J, Yang PY, Liu F
Journal of proteomics 2014 Oct 14;110:155-71
Journal of proteomics 2014 Oct 14;110:155-71
Overexpression of c1q/tumor necrosis factor-related protein-3 promotes phosphate-induced vascular smooth muscle cell calcification both in vivo and in vitro.
Zhou Y, Wang JY, Feng H, Wang C, Li L, Wu D, Lei H, Li H, Wu LL
Arteriosclerosis, thrombosis, and vascular biology 2014 May;34(5):1002-10
Arteriosclerosis, thrombosis, and vascular biology 2014 May;34(5):1002-10
Transgelin as a therapeutic target to prevent hypoxic pulmonary hypertension.
Zhang R, Shi L, Zhou L, Zhang G, Wu X, Shao F, Ma G, Ying K
American journal of physiology. Lung cellular and molecular physiology 2014 Mar 15;306(6):L574-83
American journal of physiology. Lung cellular and molecular physiology 2014 Mar 15;306(6):L574-83
Transgelin overexpression in lung adenocarcinoma is associated with tumor progression.
Wu X, Dong L, Zhang R, Ying K, Shen H
International journal of molecular medicine 2014 Aug;34(2):585-91
International journal of molecular medicine 2014 Aug;34(2):585-91
Endothelial insulin-like growth factor-1 modulates proliferation and phenotype of smooth muscle cells induced by low shear stress.
Wang L, Han Y, Shen Y, Yan ZQ, Zhang P, Yao QP, Shen BR, Gao LZ, Qi YX, Jiang ZL
Annals of biomedical engineering 2014 Apr;42(4):776-86
Annals of biomedical engineering 2014 Apr;42(4):776-86
Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis.
Meiler S, Baumer Y, Huang Z, Hoffmann FW, Fredericks GJ, Rose AH, Norton RL, Hoffmann PR, Boisvert WA
Journal of leukocyte biology 2013 May;93(5):771-80
Journal of leukocyte biology 2013 May;93(5):771-80
Adrenomedullin attenuates vascular calcification in fructose-induced insulin resistance rats.
Zhou YB, Gao Q, Li P, Han Y, Zhang F, Qi YF, Tang CS, Gao XY, Zhu GQ
Acta physiologica (Oxford, England) 2013 Mar;207(3):437-46
Acta physiologica (Oxford, England) 2013 Mar;207(3):437-46
Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer.
Zhou L, Zhang R, Zhang L, Sun Y, Yao W, Zhao A, Li J, Yuan Y
Cancer science 2013 Apr;104(4):423-30
Cancer science 2013 Apr;104(4):423-30
Serum-free differentiation of functional human coronary-like vascular smooth muscle cells from embryonic stem cells.
El-Mounayri O, Mihic A, Shikatani EA, Gagliardi M, Steinbach SK, Dubois N, Dacosta R, Li RK, Keller G, Husain M
Cardiovascular research 2013 Apr 1;98(1):125-35
Cardiovascular research 2013 Apr 1;98(1):125-35
ADAMTS-12 metalloprotease is necessary for normal inflammatory response.
Moncada-Pazos A, Obaya AJ, Llamazares M, Heljasvaara R, Suárez MF, Colado E, Noël A, Cal S, López-Otín C
The Journal of biological chemistry 2012 Nov 16;287(47):39554-63
The Journal of biological chemistry 2012 Nov 16;287(47):39554-63
Profiling of differentially expressed proteins in stage IV colorectal cancers with good and poor outcomes.
Kim HJ, Kang UB, Lee H, Jung JH, Lee ST, Yu MH, Kim H, Lee C
Journal of proteomics 2012 Jun 6;75(10):2983-97
Journal of proteomics 2012 Jun 6;75(10):2983-97
Directed differentiation of skin-derived precursors into functional vascular smooth muscle cells.
Steinbach SK, El-Mounayri O, DaCosta RS, Frontini MJ, Nong Z, Maeda A, Pickering JG, Miller FD, Husain M
Arteriosclerosis, thrombosis, and vascular biology 2011 Dec;31(12):2938-48
Arteriosclerosis, thrombosis, and vascular biology 2011 Dec;31(12):2938-48
Peptide-mediated disruption of calmodulin-cyclin E interactions inhibits proliferation of vascular smooth muscle cells and neointima formation.
Hui S, Choi J, Zaidi S, Momen A, Steinbach SK, Sadi AM, Ban K, Husain M
Circulation research 2011 Apr 29;108(9):1053-62
Circulation research 2011 Apr 29;108(9):1053-62
Up-regulation of two actin-associated proteins prompts pulmonary artery smooth muscle cell migration under hypoxia.
Zhang R, Zhou L, Li Q, Liu J, Yao W, Wan H
American journal of respiratory cell and molecular biology 2009 Oct;41(4):467-75
American journal of respiratory cell and molecular biology 2009 Oct;41(4):467-75
Dependence of proliferative vascular smooth muscle cells on CD98hc (4F2hc, SLC3A2).
Fogelstrand P, Féral CC, Zargham R, Ginsberg MH
The Journal of experimental medicine 2009 Oct 26;206(11):2397-406
The Journal of experimental medicine 2009 Oct 26;206(11):2397-406
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse colon tissue were subjected to SDS PAGE followed by western blot with 10493-1-AP( TAGLN Antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The transgelin/SM22 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human transgelin/SM22. This antibody recognizes human,mouse,rat antigen. The transgelin/SM22 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
