NBP2-48073
antibody from Novus Biologicals
Targeting: TAGLN
DKFZp686P11128, SM22, SMCC, TAGLN1, WS3-10
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Immunohistochemistry [2]
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Validation data
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- Product number
- NBP2-48073 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal Transgelin/TAGLN/SM22 alpha Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified. This MAb recognizes a 22kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.
- Reactivity
- Human, Mouse, Porcine, Rabbit, Simian
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 7 ml
- Storage
- Store at 4C.
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Transgelin/TAGLN/SM22 alpha Antibody (TAGLN/247) - IHC-Prediluted [NBP2-48073] - Human Colon Carcinoma stained with Transgelin Monoclonal Antibody (TAGLN/247)
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Transgelin/TAGLN/SM22 alpha Antibody (TAGLN/247) - IHC-Prediluted [NBP2-48073] - Human Colon Carcinoma stained with Transgelin Monoclonal Antibody (TAGLN/247)