60213-1-Ig

antibody from Proteintech Group

Targeting: TAGLN DKFZp686P11128, SM22, SMCC, TAGLN1, WS3-10

Provider product page for 60213-1-Ig

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [32]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 60213-1-Ig - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#60213-1-Ig, RRID:AB_11043177
Product name: transgelin/SM22 antibody
Antibody type: Monoclonal
Description: transgelin/SM22 antibody (Cat. #60213-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, rat, pig, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat, Porcine
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 2A10C2
Vial size: 20ul, 150ul

TAGLN protein structure - 60213-1-Ig shown in red.

Submitted references Cytoskeletal-related genes function as checkpoints for the maintenance of VSMC contractile phenotype and prevent pathological remodeling in arterial diseases.

Liu Y, Zeng L, Cai Q, Zeng Y, Zheng S, Gong X, Zhou L, Tian M, Chen L, Wu G, Zeng C
Journal of advanced research 2026 Mar;81:689-707

Macrophage κ-opioid receptor inhibits hypoxic pulmonary hypertension progression and right heart dysfunction via an SCD1-dependent anti-inflammatory response.

Wang Q, Liu J, Li R, Kong S, Wang Y, Huang G, Zhang S, Feng N, Gu X, Liu Y, Jia M, Fu F, Li J, Li J, Pei J
Genes & diseases 2026 Mar;13(2):101604

Improving erectile function in diabetic male mice by rescuing depalmitoylated FBP1 to reduce cavernosal lactate.

Xiao M, Guo W, Zeng R, Wu S, Jin X
Nature communications 2026 Jan 16;17(1):1740

Discovery of 8-quinolinesulfonamide phenylimidazole-based PKM2 agonists for the prevention and delay of aortic dissection.

Li J, Yang Y, Cheng L, Xu X, Zhong K, Wang T, Chen K, Zhang C, He C, Xu J, Xu S, Luo S
European journal of medicinal chemistry 2026 Feb 15;304:118479

Fosb promotes ferroptosis in vascular smooth muscle cells via the NF-κB pathway to exacerbate abdominal aortic aneurysm progression.

Li X, Wang Q, Zhang J, Zhao W, Zheng X
Cellular signalling 2026 Aug;144:112544

MFG-E8 in Kawasaki Disease: Role in Endothelial Injury and Diagnostic Potential.

Pei Q, Zhang J, Li M, Yang P, Jing F, Yi Q
Journal of inflammation research 2025;18:16365-16383

Quantitative evaluation of IVL: based on the tunica media gypsum calcification model and a prospective animal study.

Liu Z, Xu C, Zhao B, Guo J, Song J, Bi J, Shen Y, Dai X
Frontiers in cardiovascular medicine 2025;12:1620232

FPR2 Agonism Attenuates Restenosis by Mitigating Neointimal Hyperplasia via ELOVL6.

Zhang Q, Zha Y, Wang X, Zhao P, Woodman OL, Zhou M, Chen Y, Zhou X, Qin CX
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 15;39(17):e71020

TRPV4 maintains the contractile phenotype of VSMCs by regulating CPI-17.

Chen J, Chu Y, Lan Y, Wan J, Zhang Y, Liu Y, Yu F, Feng L, Zhu Y
Biochemical pharmacology 2025 Oct;240:117107

MIF Promotes Phenotypic Switching of VSMCs via AKT/mTOR-Mediated Autophagy Regulation in Aortic Dissection.

Pu Y, Zhou Y, Guo T, Pan X, Sun X, Yang G, Chai X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71079

Dynamic WT1 expression during gastrulation specifies peritoneal smooth muscle fate independently of mesothelial fate.

Alsukari SH, Ng HT, Lang L, Lunn S, Beglinger S, Carr L, Boyes M, Turner DA, Wilm B
Development (Cambridge, England) 2025 Jul 1;152(13)

Gut microbiota-derived butyrate prevents aortic dissection via GPR41.

Yang HX, Wang BX, Dong XL, Sun J, Miao ZL, Pan LL
Acta pharmacologica Sinica 2025 Dec;46(12):3230-3243

Hypoxanthine Promotes Pulmonary Vascular Remodeling and Adenosine Deaminase Is a Therapeutic Target for Pulmonary Hypertension.

Shi JZ, Zhu YJ, Zhang MJ, Yan Y, Zhao LL, Zhang HD, Liu Y, Wu WH, Cheng Z, Qiu CG, Kou JJ, Zhou YF, Pang XB, Chen JW, Xie XM, He YY, Jing ZC
JACC. Basic to translational science 2025 Aug;10(8):101273

miR-3529-3p/ABCA1 axis regulates smooth muscle cell homeostasis by enhancing inflammation via JAK2/STAT3 pathway.

Wang T, Yu Y, Ding Y, Yang Z, Jiang S, Gao F, Liu S, Shao L, Shen Z
Frontiers in cardiovascular medicine 2024;11:1441123

Deciphering smooth muscle cell heterogeneity in atherosclerotic plaques and constructing model: a multi-omics approach with focus on KLF15/IGFBP4 axis.

Peng Z, Kan Q, Wang K, Deng T, Wang S, Wu R, Yao C
BMC genomics 2024 May 17;25(1):490

microRNA-125b-1-3p mediates autophagy via the RRAGD/mTOR/ULK1 signaling pathway and mitigates atherosclerosis progression.

Chen X, Cao Y, Guo Y, Liu J, Ye X, Li H, Zhang L, Feng W, Xian S, Yang Z, Wang L, Wang T
Cellular signalling 2024 Jun;118:111136

Endothelial progenitor cells control remodeling of uterine spiral arteries for the establishment of utero-placental circulation.

Tan B, Lin L, Yuan Y, Long Y, Kang Y, Huang B, Huang LF, Li JH, Tong C, Qi HB
Developmental cell 2024 Jul 22;59(14):1842-1859.e12

Isolation and Cultivation of Vascular Smooth Muscle Cells from the Mouse Circle of Willis.

Chang W, Li Y, Liu F, Zang K, Zhang P, Qu S, Zhao J, Xue J
Journal of vascular research 2023;60(4):234-244

S-propargyl-cysteine promotes the stability of atherosclerotic plaque via maintaining vascular muscle contractile phenotype.

Ping L, Zhi-Ming L, Bi-Shan Z, Lei Z, Bo Y, Yi-Chun Z, Ming-Jie W
Frontiers in cell and developmental biology 2023;11:1291170

The alcohol extracts of Sceptridium ternatum (Thunb.) Lyon exert anti-pulmonary fibrosis effect through targeting SETDB1/STAT3/p-STAT3 signaling.

Zou X, Huang Z, Zhan Z, Yuan M, Zhang Y, Liu T, Hu X, Fan W, Chen P, Qin H, Zhang S, Xia Y, Zheng S, Pan Z, Huang P
Journal of ethnopharmacology 2023 Sep 15;313:116520

Non-coding RNA-mediated endothelial-to-mesenchymal transition in human diabetic cardiomyopathy, potential regulation by DNA methylation.

Wang E, Chen S, Wang H, Chen T, Chakrabarti S
Cardiovascular diabetology 2023 Nov 3;22(1):303

Identification of necroptosis-related gene TRAF5 as potential target of diagnosing atherosclerosis and assessing its stability.

Peng Z, Wang K, Wang S, Wu R, Yao C
BMC medical genomics 2023 Jun 17;16(1):139

Contribution of calcium dysregulation to impaired coronary artery contraction in Zucker diabetic fatty rats.

Liu L, Yang H, Kuang SJ, Zhang L, Zhou MY, Zeng P, Zhang MZ, Rao F, Zhou ZL, Deng CY
Clinical and experimental pharmacology & physiology 2023 Feb;50(2):158-168

The Compatibility of Alisma and Atractylodes Affects the Biological Behaviours of VSMCs by Inhibiting the miR-128-5p/p21 Gene.

Wei W, Zhou YJ, Shen JL, Lu L, Lv XR, Lu TT, Xu PT, Xue XH
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7617258

Methamphetamine induces thoracic aortic aneurysm/dissection through C/EBPβ.

Luo BY, Zhou J, Guo D, Yang Q, Tian Q, Cai DP, Zhou RM, Xu ZZ, Wang HJ, Chen SY, Xie WB
Biochimica et biophysica acta. Molecular basis of disease 2022 Sep 1;1868(9):166447

LncRNA PSR Regulates Vascular Remodeling Through Encoding a Novel Protein Arteridin.

Yu J, Wang W, Yang J, Zhang Y, Gong X, Luo H, Cao N, Xu Z, Tian M, Yang P, Mei Q, Chen Z, Li Z, Li C, Duan X, Lyu QR, Gao C, Zhang B, Wang Y, Wu G, Zeng C
Circulation research 2022 Oct 14;131(9):768-787

LDHA mediated degradation of extracellular matrix is a potential target for the treatment of aortic dissection.

Wu X, Ye J, Cai W, Yang X, Zou Q, Lin J, Zheng H, Wang C, Chen L, Li Y
Pharmacological research 2022 Feb;176:106051

Platelet-Derived Microvesicles Promote VSMC Dedifferentiation After Intimal Injury via Src/Lamtor1/mTORC1 Signaling.

Liu JT, Bao H, Fan YJ, Li ZT, Yao QP, Han Y, Zhang ML, Jiang ZL, Qi YX
Frontiers in cell and developmental biology 2021;9:744320

Insulin Resistance Promotes the Formation of Aortic Dissection by Inducing the Phenotypic Switch of Vascular Smooth Muscle Cells.

Zheng H, Qiu Z, Chai T, He J, Zhang Y, Wang C, Ye J, Wu X, Li Y, Zhang L, Chen L
Frontiers in cardiovascular medicine 2021;8:732122

The near-infrared dye IR-61 restores erectile function in a streptozotocin-induced diabetes model via mitochondrial protection.

Yue XF, Shen CX, Wang JW, Dai LY, Fang Q, Long L, Zhi Y, Li XR, Wang YW, Shen GF, Liu ZJ, Shi CM, Li WB
Asian journal of andrology 2021 May-Jun;23(3):249-258

Characterization of Carotid Smooth Muscle Cells during Phenotypic Transition.

Goikuria H, Freijo MDM, Vega Manrique R, Sastre M, Elizagaray E, Lorenzo A, Vandenbroeck K, Alloza I
Cells 2018 Mar 18;7(3)

Specific role of RhoC in tumor invasion and metastasis.

Lang S, Busch H, Boerries M, Brummer T, Timme S, Lassmann S, Aktories K, Schmidt G
Oncotarget 2017 Oct 20;8(50):87364-87378

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human colon tissue were subjected to SDS PAGE followed by western blot with 60213-1-Ig(TAGLN antibody) at dilution of 1:1000
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The transgelin/SM22 antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human transgelin/SM22. This antibody recognizes human,mouse antigen. The transgelin/SM22 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 60213-1-Ig.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon using 60213-1-Ig(TAGLN antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue