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LearnMA1-19133
antibody from Invitrogen Antibodies
Targeting: CD59
16.3A5, EJ16, EJ30, EL32, G344, MIC11, MIN1, MIN2, MIN3, MSK21, p18-20
Immunoprecipitation
Immunohistochemistry
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Flow cytometry [1]
- Other assay [5]
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- Product number
- MA1-19133 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD59 Monoclonal Antibody (MEM-43)
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- This antibody reacts with well defined epitope (W40, R-53) on CD59 (Protectin), an 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on the surface of all hematopoietic cells; it is widely present on cells in all tissues. This antibody does not compete with MEM-43/5, and has blocking activity. A suggested positive control for this product is placenta.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- MEM-43
- Vial size
- 100 µg
- Concentration
- 1 mg/mL
- Storage
- 4° C, do not freeze
Submitted references KeepEX, a simple dilution protocol for improving extracellular vesicle yields from urine.
Protective responses to sublytic complement in the retinal pigment epithelium.
CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis.
Identification of a cross-reacting, monoclonal anti-human CD233 antibody for identification and sorting of rhesus macaque erythrocytes.
Human placenta and chorion: potential additional sources of hematopoietic stem cells for transplantation.
Guidelines for the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria and related disorders by flow cytometry.
Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake.
Thrice-weekly low-dose rituximab decreases CD20 loss via shaving and promotes enhanced targeting in chronic lymphocytic leukemia.
Thrice-weekly low-dose rituximab decreases CD20 loss via shaving and promotes enhanced targeting in chronic lymphocytic leukemia.
Signature of B-CLL with different prognosis by Shrunken centroids of surface antigen expression profiling.
Identification of unsuspected PNH-type cells in flow cytometric immunophenotypic analysis of peripheral blood and bone marrow.
Searching for common stem cells of the hepatic and hematopoietic systems in the human fetal liver: CD34+ cytokeratin 7/8+ cells express markers for stellate cells.
Searching for common stem cells of the hepatic and hematopoietic systems in the human fetal liver: CD34+ cytokeratin 7/8+ cells express markers for stellate cells.
Systemic therapy with cyclophosphamide and anti-CD20 antibody (rituximab) in relapsed primary cutaneous B-cell lymphoma: a report of 7 cases.
Systemic therapy with cyclophosphamide and anti-CD20 antibody (rituximab) in relapsed primary cutaneous B-cell lymphoma: a report of 7 cases.
The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes.
The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes.
Complement regulatory molecules on human myelin and glial cells: differential expression affects the deposition of activated complement proteins.
Complement regulatory molecules on human myelin and glial cells: differential expression affects the deposition of activated complement proteins.
Phenotypic and functional analysis of lymphocytes in paroxysmal nocturnal hemoglobinuria.
Phenotypic and functional analysis of lymphocytes in paroxysmal nocturnal hemoglobinuria.
The CD59 antigen is a structural homologue of murine Ly-6 antigens but lacks interferon inducibility.
Puhka M, Nordberg ME, Valkonen S, Rannikko A, Kallioniemi O, Siljander P, Af Hällström TM
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 Feb 15;98:30-39
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 Feb 15;98:30-39
Protective responses to sublytic complement in the retinal pigment epithelium.
Tan LX, Toops KA, Lakkaraju A
Proceedings of the National Academy of Sciences of the United States of America 2016 Aug 2;113(31):8789-94
Proceedings of the National Academy of Sciences of the United States of America 2016 Aug 2;113(31):8789-94
CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis.
LaRocca TJ, Stivison EA, Mal-Sarkar T, Hooven TA, Hod EA, Spitalnik SL, Ratner AJ
Cell death & disease 2015 May 28;6(5):e1773
Cell death & disease 2015 May 28;6(5):e1773
Identification of a cross-reacting, monoclonal anti-human CD233 antibody for identification and sorting of rhesus macaque erythrocytes.
Byrnes C, Terry Lee Y, Donahue RE, Miller JL
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2012 Feb;81(2):165-8
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2012 Feb;81(2):165-8
Human placenta and chorion: potential additional sources of hematopoietic stem cells for transplantation.
Bárcena A, Muench MO, Kapidzic M, Gormley M, Goldfien GA, Fisher SJ
Transfusion 2011 Nov;51 Suppl 4(Suppl 4):94S-105S
Transfusion 2011 Nov;51 Suppl 4(Suppl 4):94S-105S
Guidelines for the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria and related disorders by flow cytometry.
Borowitz MJ, Craig FE, Digiuseppe JA, Illingworth AJ, Rosse W, Sutherland DR, Wittwer CT, Richards SJ, Clinical Cytometry Society
Cytometry. Part B, Clinical cytometry 2010 Jul;78(4):211-30
Cytometry. Part B, Clinical cytometry 2010 Jul;78(4):211-30
Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake.
Willcocks LC, Lyons PA, Clatworthy MR, Robinson JI, Yang W, Newland SA, Plagnol V, McGovern NN, Condliffe AM, Chilvers ER, Adu D, Jolly EC, Watts R, Lau YL, Morgan AW, Nash G, Smith KG
The Journal of experimental medicine 2008 Jul 7;205(7):1573-82
The Journal of experimental medicine 2008 Jul 7;205(7):1573-82
Thrice-weekly low-dose rituximab decreases CD20 loss via shaving and promotes enhanced targeting in chronic lymphocytic leukemia.
Williams ME, Densmore JJ, Pawluczkowycz AW, Beum PV, Kennedy AD, Lindorfer MA, Hamil SH, Eggleton JC, Taylor RP
Journal of immunology (Baltimore, Md. : 1950) 2006 Nov 15;177(10):7435-43
Journal of immunology (Baltimore, Md. : 1950) 2006 Nov 15;177(10):7435-43
Thrice-weekly low-dose rituximab decreases CD20 loss via shaving and promotes enhanced targeting in chronic lymphocytic leukemia.
Williams ME, Densmore JJ, Pawluczkowycz AW, Beum PV, Kennedy AD, Lindorfer MA, Hamil SH, Eggleton JC, Taylor RP
Journal of immunology (Baltimore, Md. : 1950) 2006 Nov 15;177(10):7435-43
Journal of immunology (Baltimore, Md. : 1950) 2006 Nov 15;177(10):7435-43
Signature of B-CLL with different prognosis by Shrunken centroids of surface antigen expression profiling.
Zucchetto A, Sonego P, Degan M, Bomben R, Dal Bo M, Russo S, Attadia V, Rupolo M, Buccisano F, Del Principe MI, Del Poeta G, Pucillo C, Colombatti A, Campanini R, Gattei V
Journal of cellular physiology 2005 Jul;204(1):113-23
Journal of cellular physiology 2005 Jul;204(1):113-23
Identification of unsuspected PNH-type cells in flow cytometric immunophenotypic analysis of peripheral blood and bone marrow.
Thomason RW, Papiez J, Lee RV, Szczarkowski W
American journal of clinical pathology 2004 Jul;122(1):128-34
American journal of clinical pathology 2004 Jul;122(1):128-34
Searching for common stem cells of the hepatic and hematopoietic systems in the human fetal liver: CD34+ cytokeratin 7/8+ cells express markers for stellate cells.
Suskind DL, Muench MO
Journal of hepatology 2004 Feb;40(2):261-8
Journal of hepatology 2004 Feb;40(2):261-8
Searching for common stem cells of the hepatic and hematopoietic systems in the human fetal liver: CD34+ cytokeratin 7/8+ cells express markers for stellate cells.
Suskind DL, Muench MO
Journal of hepatology 2004 Feb;40(2):261-8
Journal of hepatology 2004 Feb;40(2):261-8
Systemic therapy with cyclophosphamide and anti-CD20 antibody (rituximab) in relapsed primary cutaneous B-cell lymphoma: a report of 7 cases.
Fierro MT, Savoia P, Quaglino P, Novelli M, Barberis M, Bernengo MG
Journal of the American Academy of Dermatology 2003 Aug;49(2):281-7
Journal of the American Academy of Dermatology 2003 Aug;49(2):281-7
Systemic therapy with cyclophosphamide and anti-CD20 antibody (rituximab) in relapsed primary cutaneous B-cell lymphoma: a report of 7 cases.
Fierro MT, Savoia P, Quaglino P, Novelli M, Barberis M, Bernengo MG
Journal of the American Academy of Dermatology 2003 Aug;49(2):281-7
Journal of the American Academy of Dermatology 2003 Aug;49(2):281-7
The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes.
Solomon KR, Rudd CE, Finberg RW
Proceedings of the National Academy of Sciences of the United States of America 1996 Jun 11;93(12):6053-8
Proceedings of the National Academy of Sciences of the United States of America 1996 Jun 11;93(12):6053-8
The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes.
Solomon KR, Rudd CE, Finberg RW
Proceedings of the National Academy of Sciences of the United States of America 1996 Jun 11;93(12):6053-8
Proceedings of the National Academy of Sciences of the United States of America 1996 Jun 11;93(12):6053-8
Complement regulatory molecules on human myelin and glial cells: differential expression affects the deposition of activated complement proteins.
Koski CL, Estep AE, Sawant-Mane S, Shin ML, Highbarger L, Hansch GM
Journal of neurochemistry 1996 Jan;66(1):303-12
Journal of neurochemistry 1996 Jan;66(1):303-12
Complement regulatory molecules on human myelin and glial cells: differential expression affects the deposition of activated complement proteins.
Koski CL, Estep AE, Sawant-Mane S, Shin ML, Highbarger L, Hansch GM
Journal of neurochemistry 1996 Jan;66(1):303-12
Journal of neurochemistry 1996 Jan;66(1):303-12
Phenotypic and functional analysis of lymphocytes in paroxysmal nocturnal hemoglobinuria.
Tseng JE, Hall SE, Howard TA, Ware RE
American journal of hematology 1995 Dec;50(4):244-53
American journal of hematology 1995 Dec;50(4):244-53
Phenotypic and functional analysis of lymphocytes in paroxysmal nocturnal hemoglobinuria.
Tseng JE, Hall SE, Howard TA, Ware RE
American journal of hematology 1995 Dec;50(4):244-53
American journal of hematology 1995 Dec;50(4):244-53
The CD59 antigen is a structural homologue of murine Ly-6 antigens but lacks interferon inducibility.
Philbrick WM, Palfree RG, Maher SE, Bridgett MM, Sirlin S, Bothwell AL
European journal of immunology 1990 Jan;20(1):87-92
European journal of immunology 1990 Jan;20(1):87-92
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Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Flow cytometry analysis of CD59 using a monoclonal antibody (Product # MA1-19133).
Supportive validation
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