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- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 16612-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16612-1-AP, RRID:AB_1850928
- Product name
- BCL2L13 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated BCL2L13 antibody (Cat. #16612-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species.
Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites.
BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma.
The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc.
A role for BCL2L13 and autophagy in germline purifying selection of mtDNA.
The protective effect of inhibiting mitochondrial fission on the juvenile rat brain following PTZ kindling through inhibiting the BCL2L13/LC3 mitophagy pathway.
Profiling of purified autophagic vesicle degradome in the maturing and aging brain.
BNIP3 (BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy.
BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation.
Down-regulation of BCL2L13 renders poor prognosis in clear cell and papillary renal cell carcinoma.
BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains.
Neuroglial transmitophagy and Parkinson's disease.
Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression.
The mitophagy receptor Bcl-2-like protein 13 stimulates adipogenesis by regulating mitochondrial oxidative phosphorylation and apoptosis in mice.
A novel role for Bcl2l13 in promoting beige adipocyte biogenesis.
Degradation of altered mitochondria by autophagy is impaired in Lafora disease.
Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome.
Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation.
Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.
Yamashita SI, Sugiura Y, Matsuoka Y, Maeda R, Inoue K, Furukawa K, Fukuda T, Chan DC, Kanki T
Cell death and differentiation 2024 May;31(5):651-661
Cell death and differentiation 2024 May;31(5):651-661
Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites.
Kim JE, Park SY, Kwak C, Lee Y, Song DG, Jung JW, Lee H, Shin EA, Pinanga Y, Pyo KH, Lee EH, Kim W, Kim S, Jun CD, Yun J, Choi S, Rhee HW, Liu KH, Lee JW
Cancer communications (London, England) 2024 Jan;44(1):47-75
Cancer communications (London, England) 2024 Jan;44(1):47-75
BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma.
Wang J, Chen A, Xue Z, Liu J, He Y, Liu G, Zhao Z, Li W, Zhang Q, Chen A, Wang J, Li X, Wang X, Huang B
Cell death & disease 2023 Sep 2;14(9):585
Cell death & disease 2023 Sep 2;14(9):585
The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc.
Madhu V, Hernandez-Meadows M, Boneski PK, Qiu Y, Guntur AR, Kurland IJ, Barve RA, Risbud MV
Autophagy 2023 Jun;19(6):1821-1843
Autophagy 2023 Jun;19(6):1821-1843
A role for BCL2L13 and autophagy in germline purifying selection of mtDNA.
Kremer LS, Bozhilova LV, Rubalcava-Gracia D, Filograna R, Upadhyay M, Koolmeister C, Chinnery PF, Larsson NG
PLoS genetics 2023 Jan;19(1):e1010573
PLoS genetics 2023 Jan;19(1):e1010573
The protective effect of inhibiting mitochondrial fission on the juvenile rat brain following PTZ kindling through inhibiting the BCL2L13/LC3 mitophagy pathway.
Fang Q, Zheng S, Chen Q, Chen L, Yang Y, Wang Y, Zhang H, Chen J
Metabolic brain disease 2023 Feb;38(2):453-466
Metabolic brain disease 2023 Feb;38(2):453-466
Profiling of purified autophagic vesicle degradome in the maturing and aging brain.
Kallergi E, Siva Sankar D, Matera A, Kolaxi A, Paolicelli RC, Dengjel J, Nikoletopoulou V
Neuron 2023 Aug 2;111(15):2329-2347.e7
Neuron 2023 Aug 2;111(15):2329-2347.e7
BNIP3 (BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy.
Liu K, Zhao Q, Sun H, Liu L, Wang C, Li Z, Xu Y, Wang L, Zhang L, Zhang H, Chen Q, Zhao T
Cell death & disease 2022 Apr 11;13(4):334
Cell death & disease 2022 Apr 11;13(4):334
BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation.
da Silva Rosa SC, Martens MD, Field JT, Nguyen L, Kereliuk SM, Hai Y, Chapman D, Diehl-Jones W, Aliani M, West AR, Thliveris J, Ghavami S, Rampitsch C, Dolinsky VW, Gordon JW
Autophagy 2021 Sep;17(9):2257-2272
Autophagy 2021 Sep;17(9):2257-2272
Down-regulation of BCL2L13 renders poor prognosis in clear cell and papillary renal cell carcinoma.
Meng F, Zhang L, Zhang M, Ye K, Guo W, Liu Y, Yang W, Zhai Z, Wang H, Xiao J, Dai H
Cancer cell international 2021 Jun 30;21(1):332
Cancer cell international 2021 Jun 30;21(1):332
BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains.
Wu X, Zheng Y, Liu M, Li Y, Ma S, Tang W, Yan W, Cao M, Zheng W, Jiang L, Wu J, Han F, Qin Z, Fang L, Hu W, Chen Z, Zhang X
Autophagy 2021 Aug;17(8):1934-1946
Autophagy 2021 Aug;17(8):1934-1946
Neuroglial transmitophagy and Parkinson's disease.
Morales I, Sanchez A, Puertas-Avendaño R, Rodriguez-Sabate C, Perez-Barreto A, Rodriguez M
Glia 2020 Nov;68(11):2277-2299
Glia 2020 Nov;68(11):2277-2299
Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression.
Zhang X, Huang CR, Pan S, Pang Y, Chen YS, Zha GC, Guo KJ, Zheng X
International immunopharmacology 2020 Jun;83:106425
International immunopharmacology 2020 Jun;83:106425
The mitophagy receptor Bcl-2-like protein 13 stimulates adipogenesis by regulating mitochondrial oxidative phosphorylation and apoptosis in mice.
Fujiwara M, Tian L, Le PT, DeMambro VE, Becker KA, Rosen CJ, Guntur AR
The Journal of biological chemistry 2019 Aug 23;294(34):12683-12694
The Journal of biological chemistry 2019 Aug 23;294(34):12683-12694
A novel role for Bcl2l13 in promoting beige adipocyte biogenesis.
Ju L, Chen S, Alimujiang M, Bai N, Yan H, Fang Q, Han J, Ma X, Yang Y, Jia W
Biochemical and biophysical research communications 2018 Nov 30;506(3):485-491
Biochemical and biophysical research communications 2018 Nov 30;506(3):485-491
Degradation of altered mitochondria by autophagy is impaired in Lafora disease.
Lahuerta M, Aguado C, Sánchez-Martín P, Sanz P, Knecht E
The FEBS journal 2018 Jun;285(11):2071-2090
The FEBS journal 2018 Jun;285(11):2071-2090
Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome.
Siegmund SE, Yang H, Sharma R, Javors M, Skinner O, Mootha V, Hirano M, Schon EA
Human molecular genetics 2017 Dec 1;26(23):4588-4605
Human molecular genetics 2017 Dec 1;26(23):4588-4605
Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation.
Murakawa T, Yamaguchi O, Hashimoto A, Hikoso S, Takeda T, Oka T, Yasui H, Ueda H, Akazawa Y, Nakayama H, Taneike M, Misaka T, Omiya S, Shah AM, Yamamoto A, Nishida K, Ohsumi Y, Okamoto K, Sakata Y, Otsu K
Nature communications 2015 Jul 6;6:7527
Nature communications 2015 Jul 6;6:7527
Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.
Jensen SA, Calvert AE, Volpert G, Kouri FM, Hurley LA, Luciano JP, Wu Y, Chalastanis A, Futerman AH, Stegh AH
Proceedings of the National Academy of Sciences of the United States of America 2014 Apr 15;111(15):5682-7
Proceedings of the National Academy of Sciences of the United States of America 2014 Apr 15;111(15):5682-7
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 16612-1-AP(BCL2L13 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using BCL2L13 antibody 16612-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas using 16612-1-AP(BCL2L13 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas using 16612-1-AP(BCL2L13 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
