Antibody data
- Antibody Data
- Antigen structure
- References [20]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 12303-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12303-1-AP, RRID:AB_2162459
- Product name
- PDCD6 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PDCD6 antibody (Cat. #12303-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PDCD6 Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis through the AKT/GSK3β/β-catenin Pathway.
Lysosomal swelling and lysis mediate delivery of C3 toxins to their cytoplasmic targets.
Giant worm-shaped ESCRT scaffolds surround actin-independent integrin clusters.
Analysis of Dysferlin Direct Interactions with Putative Repair Proteins Links Apoptotic Signaling to Ca(2+) Elevation via PDCD6 and FKBP8.
Interplay in neural functions of cell adhesion molecule close homolog of L1 (CHL1) and Programmed Cell Death 6 (PDCD6).
Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion.
Co-adaptor driven assembly of a CUL3 E3 ligase complex.
Dense Granule Protein GRA64 Interacts with Host Cell ESCRT Proteins during Toxoplasma gondii Infection.
Annexins A1 and A2 are recruited to larger lysosomal injuries independently of ESCRTs to promote repair.
MAT2A facilitates PDCD6 methylation and promotes cell growth under glucose deprivation in cervical cancer.
Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cells Pyroptosis via the Circ-Calm4/miR-124-3p/PDCD6 Axis.
Genetic screening of ANXA11 revealed novel mutations linked to amyotrophic lateral sclerosis.
An epithelial-mesenchymal transition-related 5-gene signature predicting the prognosis of hepatocellular carcinoma patients.
Structural basis for dimerization quality control.
PDCD6 cooperates with C-Raf to facilitate colorectal cancer progression via Raf/MEK/ERK activation.
IL-27 posttranslationally regulates Y-box binding protein-1 to inhibit HIV-1 replication in human CD4+ T cells.
Triggered recruitment of ESCRT machinery promotes endolysosomal repair.
Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor.
Luteinizing hormone inhibits cisplatin-induced apoptosis in human epithelial ovarian cancer cells.
FSH inhibits ovarian cancer cell apoptosis by up-regulating survivin and down-regulating PDCD6 and DR5.
Wen SY, Liu YT, Wei BY, Ma JQ, Chen YY
Biomedical and environmental sciences : BES 2023 Mar 20;36(3):241-252
Biomedical and environmental sciences : BES 2023 Mar 20;36(3):241-252
Lysosomal swelling and lysis mediate delivery of C3 toxins to their cytoplasmic targets.
Turner M, Plumb J, Merrill AR, Grinstein S, Westman J
Molecular microbiology 2023 Jun;119(6):695-710
Molecular microbiology 2023 Jun;119(6):695-710
Giant worm-shaped ESCRT scaffolds surround actin-independent integrin clusters.
Stempels FC, Jiang M, Warner HM, Moser ML, Janssens MH, Maassen S, Nelen IH, de Boer R, Jiemy WF, Knight D, Selley J, O'Cualain R, Baranov MV, Burgers TCQ, Sansevrino R, Milovanovic D, Heeringa P, Jones MC, Vlijm R, Ter Beest M, van den Bogaart G
The Journal of cell biology 2023 Jul 3;222(7)
The Journal of cell biology 2023 Jul 3;222(7)
Analysis of Dysferlin Direct Interactions with Putative Repair Proteins Links Apoptotic Signaling to Ca(2+) Elevation via PDCD6 and FKBP8.
Drescher DG, Drescher MJ, Selvakumar D, Annam NP
International journal of molecular sciences 2023 Feb 28;24(5)
International journal of molecular sciences 2023 Feb 28;24(5)
Interplay in neural functions of cell adhesion molecule close homolog of L1 (CHL1) and Programmed Cell Death 6 (PDCD6).
Loers G, Theis T, Baixia Hao H, Kleene R, Arsha S, Samuel N, Arsha N, Young W, Schachner M
FASEB bioAdvances 2022 Jan;4(1):43-59
FASEB bioAdvances 2022 Jan;4(1):43-59
Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion.
Westman J, Plumb J, Licht A, Yang M, Allert S, Naglik JR, Hube B, Grinstein S, Maxson ME
Cell reports 2022 Jan 4;38(1):110187
Cell reports 2022 Jan 4;38(1):110187
Co-adaptor driven assembly of a CUL3 E3 ligase complex.
Akopian D, McGourty CA, Rapé M
Molecular cell 2022 Feb 3;82(3):585-597.e11
Molecular cell 2022 Feb 3;82(3):585-597.e11
Dense Granule Protein GRA64 Interacts with Host Cell ESCRT Proteins during Toxoplasma gondii Infection.
Mayoral J, Guevara RB, Rivera-Cuevas Y, Tu V, Tomita T, Romano JD, Gunther-Cummins L, Sidoli S, Coppens I, Carruthers VB, Weiss LM
mBio 2022 Aug 30;13(4):e0144222
mBio 2022 Aug 30;13(4):e0144222
Annexins A1 and A2 are recruited to larger lysosomal injuries independently of ESCRTs to promote repair.
Yim WW, Yamamoto H, Mizushima N
FEBS letters 2022 Apr;596(8):991-1003
FEBS letters 2022 Apr;596(8):991-1003
MAT2A facilitates PDCD6 methylation and promotes cell growth under glucose deprivation in cervical cancer.
Luo H, Song Y, Zhang JA, Liu Y, Chen F, Wang Z, Zhu X
Cell death discovery 2022 Apr 8;8(1):176
Cell death discovery 2022 Apr 8;8(1):176
Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cells Pyroptosis via the Circ-Calm4/miR-124-3p/PDCD6 Axis.
Jiang Y, Liu H, Yu H, Zhou Y, Zhang J, Xin W, Li Y, He S, Ma C, Zheng X, Zhang L, Zhao X, Wu B, Jiang C, Zhu D
Arteriosclerosis, thrombosis, and vascular biology 2021 May 5;41(5):1675-1693
Arteriosclerosis, thrombosis, and vascular biology 2021 May 5;41(5):1675-1693
Genetic screening of ANXA11 revealed novel mutations linked to amyotrophic lateral sclerosis.
Teyssou E, Muratet F, Amador MD, Ferrien M, Lautrette G, Machat S, Boillée S, Larmonier T, Saker S, Leguern E, Cazeneuve C, Marie Y, Guegan J, Gyorgy B, Cintas P, Meininger V, Le Forestier N, Salachas F, Couratier P, Camu W, Seilhean D, Millecamps S
Neurobiology of aging 2021 Mar;99:102.e11-102.e20
Neurobiology of aging 2021 Mar;99:102.e11-102.e20
An epithelial-mesenchymal transition-related 5-gene signature predicting the prognosis of hepatocellular carcinoma patients.
Zhu G, Xia H, Tang Q, Bi F
Cancer cell international 2021 Mar 12;21(1):166
Cancer cell international 2021 Mar 12;21(1):166
Structural basis for dimerization quality control.
Mena EL, Jevtić P, Greber BJ, Gee CL, Lew BG, Akopian D, Nogales E, Kuriyan J, Rape M
Nature 2020 Oct;586(7829):452-456
Nature 2020 Oct;586(7829):452-456
PDCD6 cooperates with C-Raf to facilitate colorectal cancer progression via Raf/MEK/ERK activation.
Wang X, Wu F, Wang H, Duan X, Huang R, Tuersuntuoheti A, Su L, Yan S, Zhao Y, Lu Y, Li K, Yao J, Luo Z, Guo L, Liu J, Chen X, Lu Y, Hu H, Li X, Bao M, Bi X, Du B, Miao S, Cai J, Wang L, Zhou H, Ying J, Song W, Zhao H
Journal of experimental & clinical cancer research : CR 2020 Aug 3;39(1):147
Journal of experimental & clinical cancer research : CR 2020 Aug 3;39(1):147
IL-27 posttranslationally regulates Y-box binding protein-1 to inhibit HIV-1 replication in human CD4+ T cells.
Poudyal D, Yang J, Chen Q, Goswami S, Adelsberger JW, Das S, Herman A, Hornung RL, Andresson T, Imamichi T
AIDS (London, England) 2019 Oct 1;33(12):1819-1830
AIDS (London, England) 2019 Oct 1;33(12):1819-1830
Triggered recruitment of ESCRT machinery promotes endolysosomal repair.
Skowyra ML, Schlesinger PH, Naismith TV, Hanson PI
Science (New York, N.Y.) 2018 Apr 6;360(6384)
Science (New York, N.Y.) 2018 Apr 6;360(6384)
Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor.
McGourty CA, Akopian D, Walsh C, Gorur A, Werner A, Schekman R, Bautista D, Rape M
Cell 2016 Oct 6;167(2):525-538.e14
Cell 2016 Oct 6;167(2):525-538.e14
Luteinizing hormone inhibits cisplatin-induced apoptosis in human epithelial ovarian cancer cells.
Xia L, Wen H, Han X, Tang J, Huang Y
Oncology letters 2016 Mar;11(3):1943-1947
Oncology letters 2016 Mar;11(3):1943-1947
FSH inhibits ovarian cancer cell apoptosis by up-regulating survivin and down-regulating PDCD6 and DR5.
Huang Y, Jin H, Liu Y, Zhou J, Ding J, Cheng KW, Yu Y, Feng Y
Endocrine-related cancer 2011 Feb;18(1):13-26
Endocrine-related cancer 2011 Feb;18(1):13-26
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Supportive validation
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- Proteintech Group (provider)
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- Experimental details
- The PDCD6 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PDCD6. This antibody recognizes human, mouse, rat antigen. The PDCD6 antibody has been validated for the following applications: ELISA, WB analysis.