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- Antigen structure
- References [124]
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- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 10654-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10654-1-AP, RRID:AB_2120153
- Product name
- Hsc70 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Hsc70 antibody (Cat. #10654-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Chondroitin sulfate alleviates osteoarthritis by upregulating HSPA8 to inhibit chondrocyte ferroptosis.
STING1 exacerbates iodinated contrast-induced acute kidney injury by promoting ferroptosis through chaperone-mediated autophagic degradation of FTH1.
p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer.
HSP-1-specific nanobodies alter chaperone function in vitro and in vivo.
Calcium Dysregulation Promotes Glioma Progression by Inhibiting STAT3 Degradation Through Blocking Chaperone-Mediated Autophagy.
Protective impacts of berberine in weaned piglets fed without zinc oxide: Insight of jejunal barrier function, water absorption, and gut microbiota and metabolism.
A new candidate tumor suppressor tRF-Ser inhibits gastric cancer progression by regulating the CNBP/HSPA8 axis.
Small-molecule enhancement of METTL3 S-palmitoylation as a therapeutic strategy for osteoarthritis.
Involvement of L polymerase and heat shock proteins in the biogenesis of viral circular RNAs derived from respiratory syncytial virus.
OXCT1-induced succinylation at K81 shields HADH from HSPA8-Mediated degradation in alveolar epithelial cells to attenuate lung ischemia-reperfusion injury.
Endogenous H₂S promotes HSPA8 sulfhydration to downregulate HIF1α and prevent ferroptosis in septic myocardial injury.
African swine fever virus hijacks lipolysis induced by chaperone-mediated autophagy to upregulate fatty acid β-oxidation and promote viral replication.
Identification of human MLKL Cys184 and HSPBP1 Cys201 as novel cellular targets for necroptosis.
Bafetinib enhances anti-tumor immunity by activating the NLRP3 inflammasome in macrophage.
A bifunctional peptide-selenium nanocomposite for lysosomal degradation of PD-L1 and enhanced cancer immunotherapy.
Enhanced therapeutic efficacy of anti-PD-1 blockade by targeting LAMP2A inhibits lysosomal degradation of STING and TBK1.
TFEB promotes Ginkgetin-induced ferroptosis via TRIM25 mediated GPX4 lysosomal degradation in EGFR wide-type lung adenocarcinoma.
PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation.
Identification of autophagy-related biomarkers in the circulatory system of ischemic stroke.
UBE2D2 promotes gastric cancer progression by inhibiting ferroptosis through autophagy-dependent stabilization of CST1.
Glia maturation factor-β deficiency improves insulin resistance by promoting CARM1-mediated lipid turnover.
Novel Strategy for Acquiring Metabolically-Tagged Nascent Extracellular Vesicles: Implications for Identifying Surface Protein Markers of Extracellular Vesicles From Neuroblastoma Cells Cultured With Native Serum.
CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.
Exosomal Proteome from Hepatocellular Carcinoma Patient-Derived Xenograft Mice Serves as Identity of Liver Cancer.
Acetylation of Hsc70 at K512 inhibits goat ovarian granulosa cell senescence by restoring chaperone-mediated autophagy.
Discovery of a potent inhibitor of chaperone-mediated autophagy that targets the HSC70-LAMP2A interaction in non-small cell lung cancer cells.
USP51/GRP78/ABCB1 axis confers chemoresistance through decreasing doxorubicin accumulation in triple-negative breast cancer cells.
Asb10 accelerates pathological cardiac remodeling by stabilizing HSP70.
Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila.
HSC70 coordinates COP9 signalosome and SCF ubiquitin ligase activity to enable a prompt stress response.
RBMS1-HSPA8 axis activation drives head and neck squamous cell carcinoma progression.
o8G-modified circPLCE1 inhibits lung cancer progression via chaperone-mediated autophagy.
Targeting overexpressed HSPA8 by halofuginone suppresses aberrant proliferation and invasion of rheumatoid arthritis fibroblast-like synoviocytes.
TMEM59 deficiency activates chaperone-mediated autophagy and ameliorates disease-like pathologies in tauopathy model mice.
Limiting cap-dependent translation increases 20S proteasomal degradation and protects the proteomic integrity in autophagy-deficient skeletal muscle.
Quantitative Proteome Analysis of Plasma Extracellular Vesicles Identifies Three Proteins with Potential Diagnostic Value for Mycobacterium bovis Infection in Cows.
Palmitoylation enhances the stability of porcine epidemic diarrhea virus spike protein by antagonizing its degradation via chaperone-mediated autophagy to facilitate viral proliferation.
Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death.
m5C-modified circRREB1 promotes lung cancer progression by inducing mitophagy.
Chronic sleep deprivation induces plasma exosome-derived miR-150-5p downregulation as a novel mechanism involved in Parkinson's disease progression by targeting DCLK1.
Quercetin inhibits hydrogen peroxide-induced cleavage of heat shock protein 90 to prevent glutathione peroxidase 4 degradation via chaperone-mediated autophagy.
Ethyl acetate fraction of Thesium chinense Turcz. alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis mediated by activating Nrf2/SLC7A11/GPX4 axis.
Superoxide dismutase promotes gastric tumorigenesis mediated by Helicobacter pylori and enhances resistance to 5-fluorouracil in gastric cancer.
Rab7-regulated ferroptosis contributes to tubular epithelial cells injury by degradation of GPX4 via chaperone-mediated autophagy in AKI.
From foe to friend: Rewiring oncogenic pathways through artificial selenoprotein to combat immune-resistant tumor.
Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity.
HSP-1-Specific Nanobodies Alter Chaperone Function in vitro and in vivo.
Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation.
Fine-tuned calcium homeostasis is crucial for murine erythropoiesis.
ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution.
Endosome-microautophagy targeting chimera (eMIATAC) for targeted proteins degradation and enhance CAR-T cell anti-tumor therapy.
Mesenchymal stromal cells deliver H(2)S-enhanced Nrf2 via extracellular vesicles to mediate mitochondrial homeostasis for repairing hypoxia-ischemia brain damage.
Porcine reproductive and respiratory syndrome virus degrades TANK-binding kinase 1 via chaperon-mediated autophagy to suppress type I interferon production and facilitate viral proliferation.
Transcription factor FOXM1 specifies chromatin DNA to extracellular vesicles.
Hsc70 promotes anti-tumor immunity by targeting PD-L1 for lysosomal degradation.
HSP90 Inhibition Attenuated Isoflurane-Induced Neurotoxicity in Mice and Human Neuroglioma Cells.
Salidroside directly activates HSC70, revealing a new role for HSC70 in BDNF signalling and neurogenesis after cerebral ischemia.
Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression.
Single-cell and transcriptomic analyses reveal the influence of diabetes on ovarian cancer.
TRPML1 contributes to antimony-induced nephrotoxicity by initiating ferroptosis via chaperone-mediated autophagy.
The African swine fever virus MGF300-4L protein is associated with viral pathogenicity by promoting the autophagic degradation of IKKβ and increasing the stability of IκBα.
Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis.
Apigenin Reduces Lipid Droplet Accumulation in Hepatocytes by Enhancing Chaperone-Mediated Autophagy via AMPK.
Crizotinib and its enantiomer suppress ferroptosis by decreasing PE-O-PUFA content.
Porcine reproductive and respiratory syndrome virus 2 hijacks CMA-mediated lipolysis through upregulation of small GTPase RAB18.
Dual RNA sequencing of Helicobacter pylori and host cell transcriptomes reveals ontologically distinct host-pathogen interaction.
WBP2 restrains the lysosomal degradation of GPX4 to inhibit ferroptosis in cisplatin-induced acute kidney injury.
SGLT2 inhibitor empagliflozin downregulates miRNA-34a-5p and targets GREM2 to inactivate hepatic stellate cells and ameliorate non-alcoholic fatty liver disease-associated fibrosis.
Arginine methylation of HSPA8 by PRMT9 inhibits ferroptosis to accelerate hepatitis B virus-associated hepatocellular carcinoma progression.
Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy.
Genetic Reduction of Insulin Signaling Mitigates Amyloid-β Deposition by Promoting Expression of Extracellular Matrix Proteins in the Brain.
Retromer stabilization using a pharmacological chaperone protects in an α-synuclein based mouse model of Parkinson's.
Modification of lysine-260 2-hydroxyisobutyrylation destabilizes ALDH1A1 expression to regulate bladder cancer progression.
Alphaherpesvirus upregulates NDRG1 expression to facilitate the nuclear import of viral UL31 and UL34 proteins.
C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A.
Albumosomes formed by cytoplasmic pre-folding albumin maintain mitochondrial homeostasis and inhibit nonalcoholic fatty liver disease.
Anisomycin inhibits Coxsackievirus B replication by promoting the lysosomal degradation of eEF1A1.
Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons.
The KDET Motif in the Intracellular Domain of the Cell Adhesion Molecule L1 Interacts with Several Nuclear, Cytoplasmic, and Mitochondrial Proteins Essential for Neuronal Functions.
The Interactions of the 70 kDa Fragment of Cell Adhesion Molecule L1 with Topoisomerase 1, Peroxisome Proliferator-Activated Receptor γ and NADH Dehydrogenase (Ubiquinone) Flavoprotein 2 Are Involved in Gene Expression and Neuronal L1-Dependent Functions.
Tunicamycin induces depression-like behaviors in male rats, accompanied by initiated chaperon-mediated autophagy and decreased synaptic protein expression in the hippocampus.
Endoplasmic Reticulum Protein TXNDC5 Interacts with PRDX6 and HSPA9 to Regulate Glutathione Metabolism and Lipid Peroxidation in the Hepatic AML12 Cell Line.
The Binding of HSPA8 and Mitochondrial ALDH2 Mediates Oxygen-Glucose Deprivation-Induced Fibroblast Senescence.
Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing.
HBx-Induced HSPA8 Stimulates HBV Replication and Suppresses Ferroptosis to Support Liver Cancer Progression.
One night of sleep deprivation induces release of small extracellular vesicles into circulation and promotes platelet activation by small EVs.
Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy.
Alternative splicing of the human rhomboid family-1 gene RHBDF1 inhibits epidermal growth factor receptor activation.
A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs.
Proteomic Mapping and Targeting of Mitotic Pericentriolar Material in Tumors Bearing Centrosome Amplification.
Heat Shock Protein Member 8 (HSPA8) Is Involved in Porcine Reproductive and Respiratory Syndrome Virus Attachment and Internalization.
Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregation.
Activation of GRP78 ATPase suppresses A549 lung cancer cell migration by promoting ITGB4 degradation.
Sulforaphane Ameliorates Hepatic Lipid Metabolism via Modulating Lipophagy In Vivo and In Vitro.
A Class of Disulfide Compounds Suppresses Ferroptosis by Stabilizing GPX4.
Lipophagy-ICAM-1 pathway associated with fatty acid and oxygen deficiencies is involved in poor prognoses of ovarian clear cell carcinoma.
USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy.
Bmi-1-RING1B prevents GATA4-dependent senescence-associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4.
Long noncoding RNA SH3PXD2A-AS1 promotes NSCLC proliferation and accelerates cell cycle progression by interacting with DHX9.
GPX4 degradation via chaperone-mediated autophagy contributes to antimony-triggered neuronal ferroptosis.
Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis.
MAPK-RAP1A Signaling Enriched in Hepatocellular Carcinoma Is Associated With Favorable Tumor-Infiltrating Immune Cells and Clinical Prognosis.
Sulourea-coordinated Pd nanocubes for NIR-responsive photothermal/H(2)S therapy of cancer.
Melatonin potentiates the cytotoxic effect of Neratinib in HER2(+) breast cancer through promoting endocytosis and lysosomal degradation of HER2.
Discovery of LAMP-2A as potential biomarkers for glioblastoma development by modulating apoptosis through N-CoR degradation.
The potential LXRβ agonist stigmasterol protects against hypoxia/reoxygenation injury by modulating mitophagy in primary hippocampal neurons.
Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI.
Human bronchial epithelial cell-derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF-β-WNT crosstalk.
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1.
hnRNP K Is a Novel Internal Ribosomal Entry Site-Transacting Factor That Negatively Regulates Foot-and-Mouth Disease Virus Translation and Replication and Is Antagonized by Viral 3C Protease.
Molecular identification of HSPA8 as an accessory protein of a hyperpolarization-activated chloride channel from rat pulmonary vein cardiomyocytes.
Chaperone-mediated autophagy is involved in the execution of ferroptosis.
Exosomes derived from breast cancer lung metastasis subpopulations promote tumor self-seeding.
Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death.
Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer.
MAPKs and Hsc70 are critical to the protective effect of molecular hydrogen during the early phase of acute pancreatitis.
Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death.
A panel of protein markers for the early detection of lung cancer with bronchial brushing specimens.
Proteomic study reveals a co-occurrence of gallic acid-induced apoptosis and glycolysis in B16F10 melanoma cells.
hERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562.
PKCι counteracts oxidative stress by regulating Hsc70 in an esophageal cancer cell line.
Chaperone-mediated autophagy degrades mutant p53.
Proteomic profiling of the 11-dehydrosinulariolide-treated oral carcinoma cells Ca9-22: effects on the cell apoptosis through mitochondrial-related and ER stress pathway.
An investigation into the cytotoxic effects of 13-acetoxysarcocrassolide from the soft coral Sarcophyton crassocaule on bladder cancer cells.
Jiang J, Xu Y, Dai T, Chen J, Li S, Meng Q
PloS one 2026;21(2):e0342242
PloS one 2026;21(2):e0342242
STING1 exacerbates iodinated contrast-induced acute kidney injury by promoting ferroptosis through chaperone-mediated autophagic degradation of FTH1.
Wu T, Wu X, Cai J, Tang CY, Wang XF, Zeng MY, Liu YT, Tang Y, Liu ZW, Meng W, Duan SB
Autophagy 2026 May;22(5):1081-1096
Autophagy 2026 May;22(5):1081-1096
p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer.
Tong J, Han T, Deng J, Gan Y, Ruan R, Zhao W, Xiong C, Liao Q, Chen S, Bu H, Xiong J, Zhou X, Hao Q
Redox biology 2026 Mar;90:104043
Redox biology 2026 Mar;90:104043
HSP-1-specific nanobodies alter chaperone function in vitro and in vivo.
Urban ND, Gharat K, Mattiola ZJ, Scheutzow A, Klaiss A, Tabler S, Huffaker AW, Grootveld M, Skinner ME, Zheng W, O'Meara MJ, Kirstein J, Truttmann MC
The Journal of biological chemistry 2026 Mar;302(3):111238
The Journal of biological chemistry 2026 Mar;302(3):111238
Calcium Dysregulation Promotes Glioma Progression by Inhibiting STAT3 Degradation Through Blocking Chaperone-Mediated Autophagy.
Chen J, Lai Y, Li M, Cai Z, Lu R, Liu L, Peng Y, Fu C, Xie Z, Zhou X, Liu J, Zhang H
Journal of cellular and molecular medicine 2026 Mar;30(5):e71062
Journal of cellular and molecular medicine 2026 Mar;30(5):e71062
Protective impacts of berberine in weaned piglets fed without zinc oxide: Insight of jejunal barrier function, water absorption, and gut microbiota and metabolism.
Sun Y, Liu S, Xu Y, Zhong R, Zhang L, Chen L, Zhang H
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2026 Mar;24:303-315
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2026 Mar;24:303-315
A new candidate tumor suppressor tRF-Ser inhibits gastric cancer progression by regulating the CNBP/HSPA8 axis.
Jiao J, Wang G, Liu J, Xiao K, Gao Z, Dong D, Shan K, Cui H, Shang L, Li L, Zhang C
Cell death & disease 2026 Mar 25;17(1)
Cell death & disease 2026 Mar 25;17(1)
Small-molecule enhancement of METTL3 S-palmitoylation as a therapeutic strategy for osteoarthritis.
Qin W, Wei J, Li F, Wang L, Zhang Q, Chen J, Lu P, Long T, Liu A, Cao J, Deng Y, Zhang H, Chen D, Cui J, Zhao W
Cell reports 2026 Mar 24;45(3):116993
Cell reports 2026 Mar 24;45(3):116993
Involvement of L polymerase and heat shock proteins in the biogenesis of viral circular RNAs derived from respiratory syncytial virus.
Lin M, Miao S, Yang X, Qiu Y, Mai Z, Xiao Y, Xie M, Luo Y, Ma C, Liu J, Liu Z, Yao W
mBio 2026 Mar 11;17(3):e0398025
mBio 2026 Mar 11;17(3):e0398025
OXCT1-induced succinylation at K81 shields HADH from HSPA8-Mediated degradation in alveolar epithelial cells to attenuate lung ischemia-reperfusion injury.
Li J, Guan H, Miao P, Han Z, Ding C, Jin Z, Wei L
Free radical biology & medicine 2026 Jun;249:43-59
Free radical biology & medicine 2026 Jun;249:43-59
Endogenous H₂S promotes HSPA8 sulfhydration to downregulate HIF1α and prevent ferroptosis in septic myocardial injury.
Jiankui D, Zhang S, Li Z, Li W, Weina L, Miao W, Jian X, Changnan W
Redox report : communications in free radical research 2026 Dec;31(1):2626159
Redox report : communications in free radical research 2026 Dec;31(1):2626159
African swine fever virus hijacks lipolysis induced by chaperone-mediated autophagy to upregulate fatty acid β-oxidation and promote viral replication.
Yang X, Xiong X, Liu H, Wen X, Shi X, Ma H, Wang R, Cao W, Yang F, Ru Y, Tian H, He J, Guo J, Han S, Zhu Z, Zheng H
mBio 2026 Apr 8;17(4):e0336825
mBio 2026 Apr 8;17(4):e0336825
Identification of human MLKL Cys184 and HSPBP1 Cys201 as novel cellular targets for necroptosis.
Shao H, Wu J, Han Q, Xu L, Dai P, Wang R, Li J, Wu W, Hao Y, Hou R, Chai Y, Cheng Z, Wang P, Xue L, Han T, Zhuang C
Cell death & disease 2026 Apr 22;
Cell death & disease 2026 Apr 22;
Bafetinib enhances anti-tumor immunity by activating the NLRP3 inflammasome in macrophage.
Liu D, Jin X, Zeng Y, Zhou X, Wang M, Shen H, Huang Y
Autophagy 2026 Apr 12;:1-19
Autophagy 2026 Apr 12;:1-19
A bifunctional peptide-selenium nanocomposite for lysosomal degradation of PD-L1 and enhanced cancer immunotherapy.
Wang Y, Feng J, Yan J, You W, Yan S
Frontiers in immunology 2025;16:1678911
Frontiers in immunology 2025;16:1678911
Enhanced therapeutic efficacy of anti-PD-1 blockade by targeting LAMP2A inhibits lysosomal degradation of STING and TBK1.
Wang X, Zhang D, Xiao J, Wang L, Wang J, Cui X, Tan J, Liu Y, Miao S
Theranostics 2025;15(7):3207-3222
Theranostics 2025;15(7):3207-3222
TFEB promotes Ginkgetin-induced ferroptosis via TRIM25 mediated GPX4 lysosomal degradation in EGFR wide-type lung adenocarcinoma.
Wang HJ, Dong LF, Ding LL, Miao XY, Zhang YW, Zhao LP, Yu LH, Guan ZR, Jiang YP, Tang XQ, Yan YX, Lou JS
Theranostics 2025;15(7):2991-3012
Theranostics 2025;15(7):2991-3012
PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation.
Zheng P, Hu Z, Shen Y, Gu L, Ouyang Y, Duan Y, Ji G, Dong B, Lin Y, Wen T, Tian Q, Hou Y, Zhou Q, Sun X, Chen X, Wang KL, Luo S, Wu S, Sun Y, Li M, Xiao L, Wu Q, Meng Y, Liu G, Wang Z, Bai X, Duan S, Ding Y, Bi Y, Wang Y, Li G, Liu X, Lu Z, Wu X, Tang Z, Xu D
Nature chemical biology 2025 Sep;21(9):1420-1432
Nature chemical biology 2025 Sep;21(9):1420-1432
Identification of autophagy-related biomarkers in the circulatory system of ischemic stroke.
Xu Y, Duan J, Zhong D, Yuan M, Zhang G, Zhu Z, Xie Y
Neurological research 2025 Sep 2;:1-18
Neurological research 2025 Sep 2;:1-18
UBE2D2 promotes gastric cancer progression by inhibiting ferroptosis through autophagy-dependent stabilization of CST1.
Yang Y, Xu J, Zhao Q, Zhang R, Wang Y, Shang C, Pan S, Hu C, Luo C
International journal of biological macromolecules 2025 Oct;327(Pt 2):147333
International journal of biological macromolecules 2025 Oct;327(Pt 2):147333
Glia maturation factor-β deficiency improves insulin resistance by promoting CARM1-mediated lipid turnover.
Xu J, Zhu L, Li J, Xu J, Cui T, Jia S, Zhu T, Shi S, Gao F, Jin C, Tian H, Wang J, Ou Q, Xu JY, Bi YL, Xu GT, Zhang X, Lu L
Pharmacological research 2025 Oct;220:107937
Pharmacological research 2025 Oct;220:107937
Novel Strategy for Acquiring Metabolically-Tagged Nascent Extracellular Vesicles: Implications for Identifying Surface Protein Markers of Extracellular Vesicles From Neuroblastoma Cells Cultured With Native Serum.
Markus HP, de Jong E, Makridakis M, Frantzi M, Koçer A
Journal of extracellular vesicles 2025 Oct;14(10):e70177
Journal of extracellular vesicles 2025 Oct;14(10):e70177
CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.
Li L, Zuo A, Yin R, Liu Q, Liu C, Li N, Xu D, Zhang S, Li J, Lei S, Ruan S, Li T, Guo Y
Cell death & disease 2025 Oct 7;16(1):710
Cell death & disease 2025 Oct 7;16(1):710
Exosomal Proteome from Hepatocellular Carcinoma Patient-Derived Xenograft Mice Serves as Identity of Liver Cancer.
Zuo T, Chen P, Zhang Z, Mao M, Li Y, Li Z, Feng X, Wang Y, Sun Z, Jiao F, Gao F, Zhang T, Li Y, Zhang Y, Liu F, Zhang Y, Ruan Y, Chang L, Hu L, Zhang Y, Xu P
Journal of proteome research 2025 Oct 3;24(10):4977-4987
Journal of proteome research 2025 Oct 3;24(10):4977-4987
Acetylation of Hsc70 at K512 inhibits goat ovarian granulosa cell senescence by restoring chaperone-mediated autophagy.
Li Y, Wang Y, Yao H, Li Z, Wang L, Song S, Li J, Li Y, Yang M, Zhang K, Han Y, Zhao Y, Yao S, Li Q, Ma Z, Xu D, Zhao Z
International journal of biological macromolecules 2025 May;310(Pt 2):143119
International journal of biological macromolecules 2025 May;310(Pt 2):143119
Discovery of a potent inhibitor of chaperone-mediated autophagy that targets the HSC70-LAMP2A interaction in non-small cell lung cancer cells.
Dong RF, Qin CJ, Yin Y, Han LL, Xiao CM, Wang KD, Wei RY, Xia YZ, Kong LY
British journal of pharmacology 2025 May;182(10):2287-2309
British journal of pharmacology 2025 May;182(10):2287-2309
USP51/GRP78/ABCB1 axis confers chemoresistance through decreasing doxorubicin accumulation in triple-negative breast cancer cells.
Ou Y, Zhang K, Shuai Q, Wang C, Hu H, Cao L, Qi C, Guo M, Li Z, Shi J, Liu Y, Zuo S, Chen X, Wang Y, Feng M, Wang H, Sun P, Shi Y, Yang G, Yang S
Acta pharmaceutica Sinica. B 2025 May;15(5):2593-2611
Acta pharmaceutica Sinica. B 2025 May;15(5):2593-2611
Asb10 accelerates pathological cardiac remodeling by stabilizing HSP70.
Lin K, Wei W, Chen S, Gong Y, Wang X, Wang M, Li R, Zhao Y, Xu S, Jin C, Jiang C, Fu G, Li Q
Cell death & disease 2025 May 22;16(1):409
Cell death & disease 2025 May 22;16(1):409
Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila.
Fletcher SJ, Bardossy ES, Tomé-Poderti L, Moss T, Mongelli V, Frangeul L, Blanc H, Verdier Y, Vinh J, Mukherjee S, Saleh MC
Science advances 2025 May 16;11(20):eadv1286
Science advances 2025 May 16;11(20):eadv1286
HSC70 coordinates COP9 signalosome and SCF ubiquitin ligase activity to enable a prompt stress response.
Nishimura S, Kioka H, Ding S, Hakui H, Shinomiya H, Tanabe K, Hitsumoto T, Matsuoka K, Kato H, Tsukamoto O, Asano Y, Takashima S, Enchev RI, Sakata Y
EMBO reports 2025 Mar;26(5):1344-1366
EMBO reports 2025 Mar;26(5):1344-1366
RBMS1-HSPA8 axis activation drives head and neck squamous cell carcinoma progression.
Yin X, Luo M, Zha X, Duan M, Liu Y
BMC cancer 2025 Mar 27;25(1):549
BMC cancer 2025 Mar 27;25(1):549
o8G-modified circPLCE1 inhibits lung cancer progression via chaperone-mediated autophagy.
Zhao Q, Cai D, Xu H, Gao Y, Zhang R, Zhou X, Chen X, Chen S, Wu J, Peng W, Yuan S, Li D, Li G, Nan A
Molecular cancer 2025 Mar 17;24(1):82
Molecular cancer 2025 Mar 17;24(1):82
Targeting overexpressed HSPA8 by halofuginone suppresses aberrant proliferation and invasion of rheumatoid arthritis fibroblast-like synoviocytes.
Tang Y, Wu H, Yan P, Yue Z, Hu Z, Liao X, Wang Y, Lin Y, Li L, Cai X
Pharmacological research 2025 Jun;216:107762
Pharmacological research 2025 Jun;216:107762
TMEM59 deficiency activates chaperone-mediated autophagy and ameliorates disease-like pathologies in tauopathy model mice.
Zheng N, Wang Z, Cao J, Li K, Xu H, Wang J, Zhang L, Meng J, Tang Z, Luo H, Sun H, Zhang X, Zhang YW
Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Jun;21(6):e70369
Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Jun;21(6):e70369
Limiting cap-dependent translation increases 20S proteasomal degradation and protects the proteomic integrity in autophagy-deficient skeletal muscle.
Dong H, Lyu Y, Huang CY, Tsai SY
Autophagy 2025 Jun;21(6):1212-1227
Autophagy 2025 Jun;21(6):1212-1227
Quantitative Proteome Analysis of Plasma Extracellular Vesicles Identifies Three Proteins with Potential Diagnostic Value for Mycobacterium bovis Infection in Cows.
Zhou H, Wu W, Zhang Q, Zhang T, Jiang S, Liu H, Ma Y, Chang L, Xie Y, Zhu J, Zhou D, Zhang Y, Xu P
Journal of proteome research 2025 Jun 6;24(6):2926-2938
Journal of proteome research 2025 Jun 6;24(6):2926-2938
Palmitoylation enhances the stability of porcine epidemic diarrhea virus spike protein by antagonizing its degradation via chaperone-mediated autophagy to facilitate viral proliferation.
Qian Q, Zhao S-s, Yang L, Xing G, Chen Y, Liang C, Wang H, Li R, Qiao S, Wang A, Zhang G
Journal of virology 2025 Jun 17;99(6):e0034725
Journal of virology 2025 Jun 17;99(6):e0034725
Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death.
Zhang D, Song S, Lin J, Ye T, Yang X, Jiang Q, Mi Y, Zhang M, Ge X, Shen Y, Du P, Shi Y, Zhang X, Li L, Zhang Y, Ding L, Liu J, Zhang Y, Gao S, Ye Q
Developmental cell 2025 Jul 21;60(14):1958-1973.e9
Developmental cell 2025 Jul 21;60(14):1958-1973.e9
m5C-modified circRREB1 promotes lung cancer progression by inducing mitophagy.
Cai D, Chen X, Xu H, Zhao Q, Zhou X, Wu J, Yuan S, Gao Y, Li D, Zhang R, Peng W, Li G, Nan A
Journal of experimental & clinical cancer research : CR 2025 Jul 14;44(1):203
Journal of experimental & clinical cancer research : CR 2025 Jul 14;44(1):203
Chronic sleep deprivation induces plasma exosome-derived miR-150-5p downregulation as a novel mechanism involved in Parkinson's disease progression by targeting DCLK1.
Liu L, Liu X, Zhang R, Sun X, Zhang K, Zheng B, Yang R, Yang K, Song G, Zhang Z
Journal of translational medicine 2025 Jul 11;23(1):781
Journal of translational medicine 2025 Jul 11;23(1):781
Quercetin inhibits hydrogen peroxide-induced cleavage of heat shock protein 90 to prevent glutathione peroxidase 4 degradation via chaperone-mediated autophagy.
Peng C, Li H, Mao Q, Tang K, Sun M, Ai Q, Yang Y, Liu F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156286
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156286
Ethyl acetate fraction of Thesium chinense Turcz. alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis mediated by activating Nrf2/SLC7A11/GPX4 axis.
Liu MJ, Xu ZP, Guan YQ, Wang YY, Wen XS, Li GH, Wang XN, Shen T
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118776
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118776
Superoxide dismutase promotes gastric tumorigenesis mediated by Helicobacter pylori and enhances resistance to 5-fluorouracil in gastric cancer.
Fu H, Zhang Y, Duan Y, Zhang X, Yao J, Yang D, Wei Z, Zhu Z, Xu J, Hu Z, You Q, Yan R, Wang W
iScience 2025 Feb 21;28(2):111553
iScience 2025 Feb 21;28(2):111553
Rab7-regulated ferroptosis contributes to tubular epithelial cells injury by degradation of GPX4 via chaperone-mediated autophagy in AKI.
Liu L, Wei Q, Wang R, Sun H, He S, Tang L, Zhang S, Liu Y, Yu S
American journal of physiology. Cell physiology 2025 Feb 1;328(2):C699-C709
American journal of physiology. Cell physiology 2025 Feb 1;328(2):C699-C709
From foe to friend: Rewiring oncogenic pathways through artificial selenoprotein to combat immune-resistant tumor.
You W, Zhou Z, Li Z, Yan J, Wang Y
Journal of pharmaceutical analysis 2025 Dec;15(12):101322
Journal of pharmaceutical analysis 2025 Dec;15(12):101322
Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity.
Li Y, Sheng M, Li W, Liu S, Wang B, Liu B, Luo M, Zhou X, Xia Q, Hong S, Zheng Z, Cheng SY, Jiang X, Li J, Huang T
Nature communications 2025 Dec 13;17(1):440
Nature communications 2025 Dec 13;17(1):440
HSP-1-Specific Nanobodies Alter Chaperone Function in vitro and in vivo.
Urban ND, Gharat K, Mattiola ZJ, Scheutzow A, Klaiss A, Tabler S, Huffaker AW, Grootveld M, Skinner ME, Kirstein J, Truttmann MC
bioRxiv : the preprint server for biology 2025 Aug 26;
bioRxiv : the preprint server for biology 2025 Aug 26;
Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation.
Fang R, Bai L, Verheijen BM, Li B, Dong K, Paulo JA, Zhou M, Chu YC, Song Y, Sherman MY, Gygi S, Field CM, Mitchison TJ, Lu Y
Nature communications 2025 Aug 22;16(1):7852
Nature communications 2025 Aug 22;16(1):7852
Fine-tuned calcium homeostasis is crucial for murine erythropoiesis.
Zhang S, Zhang Y, Li Y, Zhang Z, Li H, Xu M, Lu Z, Li Y, Zhao B
The FEBS journal 2025 Apr;292(8):1934-1949
The FEBS journal 2025 Apr;292(8):1934-1949
ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution.
McKenna MJ, Kraus F, Coelho JPL, Vasandani M, Zhang J, Adams BM, Paulo JA, Harper JW, Shao S
Science advances 2025 Apr 11;11(15):eadu5091
Science advances 2025 Apr 11;11(15):eadu5091
Endosome-microautophagy targeting chimera (eMIATAC) for targeted proteins degradation and enhance CAR-T cell anti-tumor therapy.
Lei K, Li J, Tu Z, Gong C, Liu J, Luo M, Ai W, Wu L, Li Y, Zhou Z, Chen Z, Lv S, Ye M, Wu M, Long X, Zhu X, Huang K
Theranostics 2024;14(11):4481-4498
Theranostics 2024;14(11):4481-4498
Mesenchymal stromal cells deliver H(2)S-enhanced Nrf2 via extracellular vesicles to mediate mitochondrial homeostasis for repairing hypoxia-ischemia brain damage.
Gai C, Li T, Zhao Y, Cheng Y, Song Y, Luo Q, Liu D, Wang Z
Free radical biology & medicine 2024 Nov 20;225:528-545
Free radical biology & medicine 2024 Nov 20;225:528-545
Porcine reproductive and respiratory syndrome virus degrades TANK-binding kinase 1 via chaperon-mediated autophagy to suppress type I interferon production and facilitate viral proliferation.
Zhao SS, Qian Q, Wang Y, Qiao S, Li R
Veterinary research 2024 Nov 14;55(1):151
Veterinary research 2024 Nov 14;55(1):151
Transcription factor FOXM1 specifies chromatin DNA to extracellular vesicles.
Zhang Y, Ding N, Li Y, Ouyang M, Fu P, Peng Y, Tan Y
Autophagy 2024 May;20(5):1054-1071
Autophagy 2024 May;20(5):1054-1071
Hsc70 promotes anti-tumor immunity by targeting PD-L1 for lysosomal degradation.
Xu X, Xie T, Zhou M, Sun Y, Wang F, Tian Y, Chen Z, Xie Y, Wu R, Cen X, Zhou J, Hou T, Zhang L, Huang C, Zhao Q, Wang D, Xia H
Nature communications 2024 May 18;15(1):4237
Nature communications 2024 May 18;15(1):4237
HSP90 Inhibition Attenuated Isoflurane-Induced Neurotoxicity in Mice and Human Neuroglioma Cells.
Zhang C, Chen X, Liu R, Zhao G
Neurochemical research 2024 Mar;49(3):706-717
Neurochemical research 2024 Mar;49(3):706-717
Salidroside directly activates HSC70, revealing a new role for HSC70 in BDNF signalling and neurogenesis after cerebral ischemia.
Lai W, Luo R, Tang Y, Yu Z, Zhou B, Yang Z, Brown J, Hong G
Phytotherapy research : PTR 2024 Jun;38(6):2619-2640
Phytotherapy research : PTR 2024 Jun;38(6):2619-2640
Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression.
Qin L, Berk M, Chung YM, Cui D, Zhu Z, Chakraborty AA, Sharifi N
Cell reports 2024 Jan 23;43(1):113575
Cell reports 2024 Jan 23;43(1):113575
Single-cell and transcriptomic analyses reveal the influence of diabetes on ovarian cancer.
Zhao Z, Wang Q, Zhao F, Ma J, Sui X, Choe HC, Chen P, Gao X, Zhang L
BMC genomics 2024 Jan 2;25(1):1
BMC genomics 2024 Jan 2;25(1):1
TRPML1 contributes to antimony-induced nephrotoxicity by initiating ferroptosis via chaperone-mediated autophagy.
Liu L, Luo C, Zheng D, Wang X, Wang R, Ding W, Shen Z, Xue P, Yu S, Liu Y, Zhao X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114378
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114378
The African swine fever virus MGF300-4L protein is associated with viral pathogenicity by promoting the autophagic degradation of IKKβ and increasing the stability of IκBα.
Wang T, Luo R, Zhang J, Lan J, Lu Z, Zhai H, Li LF, Sun Y, Qiu HJ
Emerging microbes & infections 2024 Dec;13(1):2333381
Emerging microbes & infections 2024 Dec;13(1):2333381
Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis.
Alecki C, Rizwan J, Le P, Jacob-Tomas S, Comaduran MF, Verbrugghe M, Xu JMS, Minotti S, Lynch J, Biswas J, Wu T, Durham HD, Yeo GW, Vera M
Nature communications 2024 Dec 30;15(1):10796
Nature communications 2024 Dec 30;15(1):10796
Apigenin Reduces Lipid Droplet Accumulation in Hepatocytes by Enhancing Chaperone-Mediated Autophagy via AMPK.
Lu J, Zhou H, Hu J, Zhang R, Meng Z, Guan S
Journal of agricultural and food chemistry 2024 Dec 18;72(50):27965-27977
Journal of agricultural and food chemistry 2024 Dec 18;72(50):27965-27977
Crizotinib and its enantiomer suppress ferroptosis by decreasing PE-O-PUFA content.
Cen SY, Lin F, Li X, Hu Y, Liu JP, Xue Z, Gao Y, Sun YP, Zhu S, Dang Y, Zhao Y, Yuan HX
Cell death discovery 2024 Aug 12;10(1):360
Cell death discovery 2024 Aug 12;10(1):360
Porcine reproductive and respiratory syndrome virus 2 hijacks CMA-mediated lipolysis through upregulation of small GTPase RAB18.
Li GL, Han YQ, Su BQ, Yu HS, Zhang S, Yang GY, Wang J, Liu F, Ming SL, Chu BB
PLoS pathogens 2024 Apr;20(4):e1012123
PLoS pathogens 2024 Apr;20(4):e1012123
Dual RNA sequencing of Helicobacter pylori and host cell transcriptomes reveals ontologically distinct host-pathogen interaction.
Hu W, Zhai ZY, Huang ZY, Chen ZM, Zhou P, Li XX, Yang GH, Bao CJ, You LJ, Cui XB, Xia GL, Ou Yang MP, Zhang L, Wu WKK, Li LF, Zhang YX, Xiao ZG, Gong W
mSystems 2024 Apr 16;9(4):e0020624
mSystems 2024 Apr 16;9(4):e0020624
WBP2 restrains the lysosomal degradation of GPX4 to inhibit ferroptosis in cisplatin-induced acute kidney injury.
Deng Z, Wang Y, Liu J, Zhang H, Zhou L, Zhao H, Han Y, Yan S, Dong Z, Wang Y, Dai Y, Deng F
Redox biology 2023 Sep;65:102826
Redox biology 2023 Sep;65:102826
SGLT2 inhibitor empagliflozin downregulates miRNA-34a-5p and targets GREM2 to inactivate hepatic stellate cells and ameliorate non-alcoholic fatty liver disease-associated fibrosis.
Shen Y, Cheng L, Xu M, Wang W, Wan Z, Xiong H, Guo W, Cai M, Xu F
Metabolism: clinical and experimental 2023 Sep;146:155657
Metabolism: clinical and experimental 2023 Sep;146:155657
Arginine methylation of HSPA8 by PRMT9 inhibits ferroptosis to accelerate hepatitis B virus-associated hepatocellular carcinoma progression.
Deng W, Ai J, Zhang W, Zhou Z, Li M, Yan L, Zhang L, Huang Z, Wu Z, Ai J, Jiang H
Journal of translational medicine 2023 Sep 15;21(1):625
Journal of translational medicine 2023 Sep 15;21(1):625
Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy.
Huang Y, Gu L, Li GM
Cell discovery 2023 Oct 31;9(1):107
Cell discovery 2023 Oct 31;9(1):107
Genetic Reduction of Insulin Signaling Mitigates Amyloid-β Deposition by Promoting Expression of Extracellular Matrix Proteins in the Brain.
Sano T, Ochiai T, Nagayama T, Nakamura A, Kubota N, Kadowaki T, Wakabayashi T, Iwatsubo T
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Oct 25;43(43):7226-7241
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Oct 25;43(43):7226-7241
Retromer stabilization using a pharmacological chaperone protects in an α-synuclein based mouse model of Parkinson's.
Eleuteri S, Fang TSZ, Cutillo G, Persico M, Simon DK
Research square 2023 Oct 19;
Research square 2023 Oct 19;
Modification of lysine-260 2-hydroxyisobutyrylation destabilizes ALDH1A1 expression to regulate bladder cancer progression.
Zhang Z, Wang Y, Liang Z, Meng Z, Zhang X, Ma G, Chen Y, Zhang M, Su Y, Li Z, Liang Y, Niu H
iScience 2023 Nov 17;26(11):108142
iScience 2023 Nov 17;26(11):108142
Alphaherpesvirus upregulates NDRG1 expression to facilitate the nuclear import of viral UL31 and UL34 proteins.
Zhang S, Ming SL, Zeng L, Wang LF, Zhang C, Zhu HS, Yang GY, Zhang GP, Chu BB, Wang J
Journal of medical virology 2023 Mar;95(3):e28591
Journal of medical virology 2023 Mar;95(3):e28591
C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A.
Tan J, Wang W, Liu X, Xu J, Che Y, Liu Y, Hu J, Hu L, Li J, Zhou Q
Communications biology 2023 Jun 5;6(1):606
Communications biology 2023 Jun 5;6(1):606
Albumosomes formed by cytoplasmic pre-folding albumin maintain mitochondrial homeostasis and inhibit nonalcoholic fatty liver disease.
Ma B, Ju A, Zhang S, An Q, Xu S, Liu J, Yu L, Fu Y, Luo Y
Signal transduction and targeted therapy 2023 Jun 16;8(1):229
Signal transduction and targeted therapy 2023 Jun 16;8(1):229
Anisomycin inhibits Coxsackievirus B replication by promoting the lysosomal degradation of eEF1A1.
Shao E, Zhao S, Dong Y, Wang Y, Fei Y, Li S, Wang L, Bashir T, Luan T, Lin L, Wang Y, Zhao W, Zhong Z
Antiviral research 2023 Jul;215:105621
Antiviral research 2023 Jul;215:105621
Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons.
Mun SH, Lee CS, Kim HJ, Kim J, Lee H, Yang J, Im SH, Kim JH, Seong JK, Hwang CS
Cell reports 2023 Jul 25;42(7):112746
Cell reports 2023 Jul 25;42(7):112746
The KDET Motif in the Intracellular Domain of the Cell Adhesion Molecule L1 Interacts with Several Nuclear, Cytoplasmic, and Mitochondrial Proteins Essential for Neuronal Functions.
Kleene R, Loers G, Schachner M
International journal of molecular sciences 2023 Jan 4;24(2)
International journal of molecular sciences 2023 Jan 4;24(2)
The Interactions of the 70 kDa Fragment of Cell Adhesion Molecule L1 with Topoisomerase 1, Peroxisome Proliferator-Activated Receptor γ and NADH Dehydrogenase (Ubiquinone) Flavoprotein 2 Are Involved in Gene Expression and Neuronal L1-Dependent Functions.
Loers G, Kleene R, Bork U, Schachner M
International journal of molecular sciences 2023 Jan 20;24(3)
International journal of molecular sciences 2023 Jan 20;24(3)
Tunicamycin induces depression-like behaviors in male rats, accompanied by initiated chaperon-mediated autophagy and decreased synaptic protein expression in the hippocampus.
Yuan G, Xiao L, Xie Y, Si L, Xu H, Xu W, Wang G
Neuroscience letters 2023 Feb 28;798:137058
Neuroscience letters 2023 Feb 28;798:137058
Endoplasmic Reticulum Protein TXNDC5 Interacts with PRDX6 and HSPA9 to Regulate Glutathione Metabolism and Lipid Peroxidation in the Hepatic AML12 Cell Line.
Bidooki SH, Sánchez-Marco J, Martínez-Beamonte R, Herrero-Continente T, Navarro MA, Rodríguez-Yoldi MJ, Osada J
International journal of molecular sciences 2023 Dec 5;24(24)
International journal of molecular sciences 2023 Dec 5;24(24)
The Binding of HSPA8 and Mitochondrial ALDH2 Mediates Oxygen-Glucose Deprivation-Induced Fibroblast Senescence.
Hui W, Song T, Yu L, Chen X
Antioxidants (Basel, Switzerland) 2023 Dec 25;13(1)
Antioxidants (Basel, Switzerland) 2023 Dec 25;13(1)
Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing.
Lv D, Cao X, Zhong L, Dong Y, Xu Z, Rong Y, Xu H, Wang Z, Yang H, Yin R, Chen M, Ke C, Hu Z, Deng W, Tang B
Cell reports. Medicine 2023 Aug 15;4(8):101129
Cell reports. Medicine 2023 Aug 15;4(8):101129
HBx-Induced HSPA8 Stimulates HBV Replication and Suppresses Ferroptosis to Support Liver Cancer Progression.
Wang Y, Zhao M, Zhao L, Geng Y, Li G, Chen L, Yu J, Yuan H, Zhang H, Yun H, Yuan Y, Wang G, Feng J, Xu L, Wang S, Hou C, Yang G, Zhang N, Lu W, Zhang X
Cancer research 2023 Apr 4;83(7):1048-1061
Cancer research 2023 Apr 4;83(7):1048-1061
One night of sleep deprivation induces release of small extracellular vesicles into circulation and promotes platelet activation by small EVs.
Wang C, Li L, Yang C, Zhang Z, Li X, Wang Y, Lv X, Qi X, Song G
Journal of cellular and molecular medicine 2022 Oct;26(19):5033-5043
Journal of cellular and molecular medicine 2022 Oct;26(19):5033-5043
Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy.
Liu C, Sun W, Zhu T, Shi S, Zhang J, Wang J, Gao F, Ou Q, Jin C, Li J, Xu JY, Zhang J, Tian H, Xu GT, Lu L
Redox biology 2022 Jun;52:102292
Redox biology 2022 Jun;52:102292
Alternative splicing of the human rhomboid family-1 gene RHBDF1 inhibits epidermal growth factor receptor activation.
Ji R, Shi Q, Cao Y, Zhang J, Zhao C, Zhao H, Sayyed Y, Fu L, Li LY
The Journal of biological chemistry 2022 Jun;298(6):102033
The Journal of biological chemistry 2022 Jun;298(6):102033
A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs.
Liu X, Mei W, Padmanaban V, Alwaseem H, Molina H, Passarelli MC, Tavora B, Tavazoie SF
Molecular cell 2022 Jul 21;82(14):2604-2617.e8
Molecular cell 2022 Jul 21;82(14):2604-2617.e8
Proteomic Mapping and Targeting of Mitotic Pericentriolar Material in Tumors Bearing Centrosome Amplification.
Xie B, Pu Y, Yang F, Chen W, Yue W, Ma J, Zhang N, Jiang Y, Wu J, Lin Y, Liang X, Wang C, Zou P, Li M
Cancer research 2022 Jul 18;82(14):2576-2592
Cancer research 2022 Jul 18;82(14):2576-2592
Heat Shock Protein Member 8 (HSPA8) Is Involved in Porcine Reproductive and Respiratory Syndrome Virus Attachment and Internalization.
Wang L, Li R, Geng R, Zhang L, Chen XX, Qiao S, Zhang G
Microbiology spectrum 2022 Feb 23;10(1):e0186021
Microbiology spectrum 2022 Feb 23;10(1):e0186021
Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregation.
Liu F, Morderer D, Wren MC, Vettleson-Trutza SA, Wang Y, Rabichow BE, Salemi MR, Phinney BS, Oskarsson B, Dickson DW, Rossoll W
Acta neuropathologica communications 2022 Feb 14;10(1):22
Acta neuropathologica communications 2022 Feb 14;10(1):22
Activation of GRP78 ATPase suppresses A549 lung cancer cell migration by promoting ITGB4 degradation.
Ning J, Cui X, Li N, Li N, Zhao B, Miao J, Lin Z
Cell adhesion & migration 2022 Dec;16(1):107-114
Cell adhesion & migration 2022 Dec;16(1):107-114
Sulforaphane Ameliorates Hepatic Lipid Metabolism via Modulating Lipophagy In Vivo and In Vitro.
Lei P, Hu Y, Gao P, Ding Q, Yan J, Zhao J, Li B, Shan Y
Journal of agricultural and food chemistry 2022 Dec 7;70(48):15126-15133
Journal of agricultural and food chemistry 2022 Dec 7;70(48):15126-15133
A Class of Disulfide Compounds Suppresses Ferroptosis by Stabilizing GPX4.
Liu JP, Cen SY, Xue Z, Wang TX, Gao Y, Zheng J, Zhang C, Hu J, Nie S, Xiong Y, Guan KL, Yuan HX
ACS chemical biology 2022 Dec 16;17(12):3389-3406
ACS chemical biology 2022 Dec 16;17(12):3389-3406
Lipophagy-ICAM-1 pathway associated with fatty acid and oxygen deficiencies is involved in poor prognoses of ovarian clear cell carcinoma.
Koizume S, Takahashi T, Nakamura Y, Yoshihara M, Ota Y, Sato S, Tadokoro H, Yokose T, Kato H, Miyagi E, Miyagi Y
British journal of cancer 2022 Aug;127(3):462-473
British journal of cancer 2022 Aug;127(3):462-473
USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy.
Zhao X, Di Q, Yu J, Quan J, Xiao Y, Zhu H, Li H, Ling J, Chen W
Autophagy 2022 Apr;18(4):891-908
Autophagy 2022 Apr;18(4):891-908
Bmi-1-RING1B prevents GATA4-dependent senescence-associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4.
Chen H, Zhou J, Chen H, Liang J, Xie C, Gu X, Wang R, Mao Z, Zhang Y, Li Q, Zuo G, Miao D, Jin J
Clinical and translational medicine 2022 Apr;12(4):e574
Clinical and translational medicine 2022 Apr;12(4):e574
Long noncoding RNA SH3PXD2A-AS1 promotes NSCLC proliferation and accelerates cell cycle progression by interacting with DHX9.
Zhou Y, Yong H, Cui W, Chu S, Li M, Li Z, Bai J, Zhang H
Cell death discovery 2022 Apr 11;8(1):192
Cell death discovery 2022 Apr 11;8(1):192
GPX4 degradation via chaperone-mediated autophagy contributes to antimony-triggered neuronal ferroptosis.
Yu S, Li Z, Zhang Q, Wang R, Zhao Z, Ding W, Wang F, Sun C, Tang J, Wang X, Zhang H, Huang R, Wu Q, Jiang J, Zhao X
Ecotoxicology and environmental safety 2022 Apr 1;234:113413
Ecotoxicology and environmental safety 2022 Apr 1;234:113413
Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis.
Jin C, Ou Q, Chen J, Wang T, Zhang J, Wang Z, Wang Y, Tian H, Xu JY, Gao F, Wang J, Li J, Lu L, Xu GT
Stem cell research & therapy 2022 Apr 1;13(1):136
Stem cell research & therapy 2022 Apr 1;13(1):136
MAPK-RAP1A Signaling Enriched in Hepatocellular Carcinoma Is Associated With Favorable Tumor-Infiltrating Immune Cells and Clinical Prognosis.
Li H, Han G, Li X, Li B, Wu B, Jin H, Wu L, Wang W
Frontiers in oncology 2021;11:649980
Frontiers in oncology 2021;11:649980
Sulourea-coordinated Pd nanocubes for NIR-responsive photothermal/H(2)S therapy of cancer.
Guo X, Liu J, Jiang L, Gong W, Wu H, He Q
Journal of nanobiotechnology 2021 Oct 14;19(1):321
Journal of nanobiotechnology 2021 Oct 14;19(1):321
Melatonin potentiates the cytotoxic effect of Neratinib in HER2(+) breast cancer through promoting endocytosis and lysosomal degradation of HER2.
Liu Z, Sang X, Wang M, Liu Y, Liu J, Wang X, Liu P, Cheng H
Oncogene 2021 Nov;40(44):6273-6283
Oncogene 2021 Nov;40(44):6273-6283
Discovery of LAMP-2A as potential biomarkers for glioblastoma development by modulating apoptosis through N-CoR degradation.
Wang Y, Zhang B, Wang J, Wu H, Xu S, Zhang J, Wang L
Cell communication and signaling : CCS 2021 Mar 24;19(1):40
Cell communication and signaling : CCS 2021 Mar 24;19(1):40
The potential LXRβ agonist stigmasterol protects against hypoxia/reoxygenation injury by modulating mitophagy in primary hippocampal neurons.
Haque MN, Hannan MA, Dash R, Choi SM, Moon IS
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;81:153415
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;81:153415
Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI.
Chen C, Wang D, Yu Y, Zhao T, Min N, Wu Y, Kang L, Zhao Y, Du L, Zhang M, Gong J, Zhang Z, Zhang Y, Mi X, Yue S, Tan X
Cell death & disease 2021 Jan 11;12(1):65
Cell death & disease 2021 Jan 11;12(1):65
Human bronchial epithelial cell-derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF-β-WNT crosstalk.
Kadota T, Fujita Y, Araya J, Watanabe N, Fujimoto S, Kawamoto H, Minagawa S, Hara H, Ohtsuka T, Yamamoto Y, Kuwano K, Ochiya T
Journal of extracellular vesicles 2021 Aug;10(10):e12124
Journal of extracellular vesicles 2021 Aug;10(10):e12124
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1.
Tao P, Sun J, Wu Z, Wang S, Wang J, Li W, Pan H, Bai R, Zhang J, Wang Y, Lee PY, Ying W, Zhou Q, Hou J, Wang W, Sun B, Yang M, Liu D, Fang R, Han H, Yang Z, Huang X, Li H, Deuitch N, Zhang Y, Dissanayake D, Haude K, McWalter K, Roadhouse C, MacKenzie JJ, Laxer RM, Aksentijevich I, Yu X, Wang X, Yuan J, Zhou Q
Nature 2020 Jan;577(7788):109-114
Nature 2020 Jan;577(7788):109-114
hnRNP K Is a Novel Internal Ribosomal Entry Site-Transacting Factor That Negatively Regulates Foot-and-Mouth Disease Virus Translation and Replication and Is Antagonized by Viral 3C Protease.
Liu W, Yang D, Sun C, Wang H, Zhao B, Zhou G, Yu L
Journal of virology 2020 Aug 17;94(17)
Journal of virology 2020 Aug 17;94(17)
Molecular identification of HSPA8 as an accessory protein of a hyperpolarization-activated chloride channel from rat pulmonary vein cardiomyocytes.
Okamoto Y, Nagasawa Y, Obara Y, Ishii K, Takagi D, Ono K
The Journal of biological chemistry 2019 Nov 1;294(44):16049-16061
The Journal of biological chemistry 2019 Nov 1;294(44):16049-16061
Chaperone-mediated autophagy is involved in the execution of ferroptosis.
Wu Z, Geng Y, Lu X, Shi Y, Wu G, Zhang M, Shan B, Pan H, Yuan J
Proceedings of the National Academy of Sciences of the United States of America 2019 Feb 19;116(8):2996-3005
Proceedings of the National Academy of Sciences of the United States of America 2019 Feb 19;116(8):2996-3005
Exosomes derived from breast cancer lung metastasis subpopulations promote tumor self-seeding.
Huang H, Zheng X, Cai C, Yao Z, Lu S, Meng X, Miao Y, He Z, Cai C, Zou F
Biochemical and biophysical research communications 2018 Sep 3;503(1):242-248
Biochemical and biophysical research communications 2018 Sep 3;503(1):242-248
Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death.
Ouchida AT, Li Y, Geng J, Najafov A, Ofengeim D, Sun X, Yu Q, Yuan J
Cell death & disease 2018 Jan 26;9(2):138
Cell death & disease 2018 Jan 26;9(2):138
Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer.
Liu B, Wang T, Wang H, Zhang L, Xu F, Fang R, Li L, Cai X, Wu Y, Zhang W, Ye L
Journal of hematology & oncology 2018 Feb 23;11(1):26
Journal of hematology & oncology 2018 Feb 23;11(1):26
MAPKs and Hsc70 are critical to the protective effect of molecular hydrogen during the early phase of acute pancreatitis.
Han B, Zhou H, Jia G, Wang Y, Song Z, Wang G, Pan S, Bai X, Lv J, Sun B
The FEBS journal 2016 Feb;283(4):738-56
The FEBS journal 2016 Feb;283(4):738-56
Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death.
Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, Wu K, Cai Y, Yates JR, Zhu Z, Yuan J, Vakifahmetoglu-Norberg H
The Journal of cell biology 2015 Aug 31;210(5):705-16
The Journal of cell biology 2015 Aug 31;210(5):705-16
A panel of protein markers for the early detection of lung cancer with bronchial brushing specimens.
Liu YZ, Jiang YY, Wang BS, Hao JJ, Shang L, Zhang TT, Cao J, Xu X, Zhan QM, Wang MR
Cancer cytopathology 2014 Nov;122(11):833-41
Cancer cytopathology 2014 Nov;122(11):833-41
Proteomic study reveals a co-occurrence of gallic acid-induced apoptosis and glycolysis in B16F10 melanoma cells.
Liu C, Lin JJ, Yang ZY, Tsai CC, Hsu JL, Wu YJ
Journal of agricultural and food chemistry 2014 Dec 3;62(48):11672-80
Journal of agricultural and food chemistry 2014 Dec 3;62(48):11672-80
hERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562.
Ma J, Hu Y, Guo M, Huang Z, Li W, Wu Y
PloS one 2013;8(12):e84903
PloS one 2013;8(12):e84903
PKCι counteracts oxidative stress by regulating Hsc70 in an esophageal cancer cell line.
Wang BS, Yang Y, Yang H, Liu YZ, Hao JJ, Zhang Y, Shi ZZ, Jia XM, Zhan QM, Wang MR
Cell stress & chaperones 2013 May;18(3):359-66
Cell stress & chaperones 2013 May;18(3):359-66
Chaperone-mediated autophagy degrades mutant p53.
Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J
Genes & development 2013 Aug 1;27(15):1718-30
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 10654-1-AP(HSPA8 antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-HSPA8 (IP:10654-1-AP, 3ug; Detection:10654-1-AP 1:1000) with HEK-293 cells lysate 2500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Hsc70 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Hsc70. This antibody recognizes human,mouse,rat antigen. The Hsc70 antibody has been validated for the following applications: ELISA, IHC, IP, WB analysis.
