66442-1-Ig

antibody from Proteintech Group

Targeting: HSPA8 HSC70, HSC71, HSP73, HSPA10

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66442-1-Ig

Provider

Proteintech Group

Product name

Hsc70 antibody

Antibody type

Monoclonal

Description

Hsc70 antibody (Cat. #66442-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1A4B3

Vial size

20ul, 150ul

References

Submitted references

ACE2 mitigates Streptococcus uberis-induced ferroptosis in goat mammary epithelial cells by inhibiting ROS-chaperone-mediated autophagic degradation of GPX4.

Wu G, Ma C, Xu J, Chen X, Chen X, Wang G, Zhang Y
Microbial pathogenesis 2026 Jan;210:108141

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Goat bone marrow mesenchymal stem cell angiotensin-converting enzyme 2 attenuates Streptococcus uberis-induced ferroptosis in goat mammary epithelial cells by downregulating the reactive oxygen species-chaperone-mediated autophagy pathway.

Wu G, Xu J, Chen X, Wang G, Zhang Y
Journal of dairy science 2026 Feb;109(2):1854-1873

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Engineering of an Exosome-Based GPIHBP1 mRNA Delivery System for Efficient Therapy of Familial Hypertriglyceridemia.

Cao Y, Meng X, Xu X, Xia C, Yang C, Cui X, He Q, Song G
Journal of medicinal chemistry 2025 Sep 25;68(18):19554-19566

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Heat shock protein A1 inhibits the replication of foot-and-mouth disease virus by degrading viral RNA polymerase 3D through chaperone-mediated autophagy.

Ren M, Zhou H, Wu J-e, Wang J-n, Wang X, Abdullah SW, Guo H, Sun S
Journal of virology 2025 May 20;99(5):e0016825

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HSC70 coordinates COP9 signalosome and SCF ubiquitin ligase activity to enable a prompt stress response.

Nishimura S, Kioka H, Ding S, Hakui H, Shinomiya H, Tanabe K, Hitsumoto T, Matsuoka K, Kato H, Tsukamoto O, Asano Y, Takashima S, Enchev RI, Sakata Y
EMBO reports 2025 Mar;26(5):1344-1366

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Deficiency of HSF4 Increases the Secretion of Small Extracellular Vesicles via Upregulation of Chaperone-Mediated Autophagy.

Liu J, Liu X, Xie X, Si W, Zhang Y, Xue M, Peng X, Jiang M, Du S, Shao J, Mao Y, Zhang F, Hu Y
Journal of cellular biochemistry 2025 Apr;126(4):e70031

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TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington's disease.

Qin Y, Chen L, Zhu W, Song J, Lin J, Li Y, Zhang J, Song X, Xing T, Guo T, Duan X, Zhang Y, Ruan E, Wang Q, Li B, Yang W, Yin P, Yan XX, Li S, Li XJ, Yang S
Science advances 2024 May 17;10(20):eadl2036

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Arginine methylation of HSPA8 by PRMT9 inhibits ferroptosis to accelerate hepatitis B virus-associated hepatocellular carcinoma progression.

Deng W, Ai J, Zhang W, Zhou Z, Li M, Yan L, Zhang L, Huang Z, Wu Z, Ai J, Jiang H
Journal of translational medicine 2023 Sep 15;21(1):625

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C-IGF1R encoded by cIGF1R acts as a molecular switch to restrict mitophagy of drug-tolerant persister tumour cells in non-small cell lung cancer.

Wang H, Liang Y, Zhang T, Yu X, Song X, Chen Y, Mao Q, Xia W, Chen B, Xu L, Dong G, Jiang F
Cell death and differentiation 2023 Nov;30(11):2365-2381

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A curcumin analogue GO-Y030 depletes cancer stem cells by inhibiting the interaction between the HSP70/HSP40 complex and its substrates.

Suzuki M, Yamamoto Y, Nishijima-Matsunobu A, Kawasaki Y, Shibata H, Omori Y
FEBS open bio 2023 Mar;13(3):434-446

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PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration.

Zhang H, Xie Z, Peng Y, Xie A, Fu C, Zheng D, Cai Z, Zhong J, Ming Q, Li M, Lu R, Liu X, Chen J
Ecotoxicology and environmental safety 2023 Mar 1;252:114630

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Integrative Proteomics and Transcriptomics Profiles of the Oviduct Reveal the Prolificacy-Related Candidate Biomarkers of Goats (Capra hircus) in Estrous Periods.

Sun Z, Liu Y, He X, Di R, Wang X, Ren C, Zhang Z, Chu M
International journal of molecular sciences 2022 Nov 28;23(23)

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Heat Shock Protein Member 8 (HSPA8) Is Involved in Porcine Reproductive and Respiratory Syndrome Virus Attachment and Internalization.

Wang L, Li R, Geng R, Zhang L, Chen XX, Qiao S, Zhang G
Microbiology spectrum 2022 Feb 23;10(1):e0186021

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Discovery of LAMP-2A as potential biomarkers for glioblastoma development by modulating apoptosis through N-CoR degradation.

Wang Y, Zhang B, Wang J, Wu H, Xu S, Zhang J, Wang L
Cell communication and signaling : CCS 2021 Mar 24;19(1):40

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p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease.

Chen J, Mao K, Yu H, Wen Y, She H, Zhang H, Liu L, Li M, Li W, Zou F
Journal of neuroinflammation 2021 Dec 20;18(1):295