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Learn60318-1-Ig
antibody from Proteintech Group
Targeting: HSP90AA1
FLJ31884, Hsp89, Hsp90, HSP90N, HSPC1, HSPCA
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [138]
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- Validations
- Western blot [1]
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- Product number
- 60318-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- HSP90 antibody
- Antibody type
- Monoclonal
- Description
- HSP90 antibody (Cat. #60318-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat, pig and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 3F11C1
- Vial size
- 20ul, 150ul
Submitted references Novel Dual-Pharmacophore TrxR Inhibitors Integrating Ferroptosis and Antitumor Immunity: A Closed-Loop Strategy for TIME Remodeling.
The HSP90-dependent bioorthogonal PROTAC prodrug system enables tumor-selective and enhanced protein degradation.
Exercise training alleviates myocardial injury in mice with heart failure with preserved ejection fraction via the TLR4-mediated necroptosis pathway.
BMSC-derived extracellular vesicles enhance osteosarcoma proliferation and metastasis via the circRNA-0010220/β-catenin pathway.
Betaine-homocysteine methyltransferase protects against acetaminophen-induced acute liver failure via BACH1-SCD1-oleic acid axis.
O-GlcNAcylation of AMFR stabilizes TSPAN4 to regulate migrasome formation for viral release.
SLC38A1 Inhibits Ferroptosis of Alveolar Type II Epithelial Cells in Acute Lung Injury by Promoting Autophagic Degradation of Divalent Metal Transporter 1 (DMT1): an In Vivo and In Vitro Study.
Partial embryo loss caused by disruption of the placental hormone CTRP6 coincides with dNK cell abnormalities during pregnancy.
Combination of GLP-1 receptor agonist and Akkermansia muciniphila Akk11 reduces adiposity and ameliorates MASLD in T2D mice.
Nobiletin alleviates heat stress-induced meiotic arrest via restoring CDK1 and MAPK activity in porcine oocytes.
HSP90α facilitates the dephosphorylation of DRP1 at the Ser637 residue, thereby promoting NLRP3 inflammasome activation and exacerbating brain injury in sepsis.
Energy stress activates AMPK to arrest mitochondria via phosphorylation of TRAK1.
Vascular smooth muscle RbFox2 regulates the cytoskeleton and arterial stiffness by a RhoBTB1-Cullin-3 mechanism.
Withaferin-A inhibits colorectal cancer growth and metastasis by targeting the HSP90/HIF-1α/EMT axis.
circSLC39A8 by sponging hsa-miR-11181-5p and direct binding to PIK3CA mRNA promotes retinoblastoma proliferation.
USP8-Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity.
Integrative Analysis of Metabolome and Transcriptome Identifies the Role of γ-Glutamylcysteine in Mitigating Deoxynivalenol-Induced Toxicity.
Engineered platelets as targeted protein degraders and application to breast cancer models.
Serine/Threonine Kinase 33 as a Novel Target of Bufalin in Treatment of Triple-Negative Breast Cancer.
HSP70 chaperones IL-33 in chronic airway disease.
Extracellular HSP90-Facilitated Degradation of Extracellular and Membrane Proteins by Bifunctional Small Molecules.
STAT3-controlled CHI3L1/SPP1 positive feedback loop demonstrates the spatial heterogeneity and immune characteristics of glioblastoma.
Depletion of Fat Mass and Obesity-Associated Protein (FTO) Drives Heterochromatin Loss via Lysine Acetyltransferase 8 (KAT8)-Mediated Remodeling and Spacing Factor 1 (RSF1) Acetylation in Skin Aging.
Secreted EMC10 inhibits muscle GLUT4 activity and glucose uptake in mice.
(124)I-labelled BMSC-Derived Extracellular Vesicles Deliver CRISPR/Cas9 Ribonucleoproteins With a GFP-Reporter System to Inhibit Osteosarcoma Proliferation and Metastasis.
Swimming exercise reduces H-type vessels by down-regulating the Hif-1α/VEGFa pathway in mice with osteoarthritis of the knee.
Acetate Administration Ameliorates Streptozotocin-Induced Hyperglycemia and Adipose Tissue Loss.
Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis.
Jahn-Teller distortion-engineered self-propelled nanorobots for mitochondrial targeting and bioenergetic disruption in tumor therapy.
PSPC1-SMAD3 axis regulates iron-induced beiging of adipocytes in white adipose tissue.
Identification of the Role of NAT10 in the Regulation of Porcine Circovirus Type 2 Infection.
The C1QTNF6-MX2 Antiviral Axis Inhibits Porcine Circovirus Type 2 Replication in Porcine Macrophages.
Aurora A degradation by HSP90 interactome-mediating PROTACs in A549 and paclitaxel-resistant A549 cells.
Upregulating mTOR/S6 K Pathway by CASTOR1 Promotes Astrocyte Proliferation and Myelination in Gpam(-/-)-induced mouse model of cerebral palsy.
Upregulation of E3 ligase UBR2 in acetaldehyde-treated C2C12 myotubes and its potential involvement in fast-twitch muscle atrophy in alcohol-fed rats.
Downregulated TFPI2 Accelerates Skin Aging by Repressing the Cell Cycle through Phosphoinositide 3-Kinase/Protein Kinase B/CDC6 Pathway.
HSP70 is a chaperone for IL-33 activity in chronic airway disease.
Constraint-induced movement therapy combined with mesenchymal stem cell transplantation promotes myelination and functional recovery by inhibiting PRKCD/MEK/ERK pathway in hemiplegic cerebral palsy rats.
Analysis of the Role of KLF4 in the Regulation of Porcine Epidemic Diarrhea Virus Infection.
p23 protects against ferroptosis of brain microvascular endothelial cells in ischemic stroke.
Isoforskolin, adenylate cyclase agonist, inhibits endothelial-to-mesenchymal transition in atherosclerosis.
Systematic pharmacology-based strategy to investigate the mechanism of beta-sitosterol for the treatment of rheumarthritis.
G-Protein-Coupled Receptor Kinase 2 Inhibition Induces Meiotic Arrest by Disturbing Ca(2+) Release in Porcine Oocytes.
Synthesis and characterization of (64)Cu-labeled Geldanamycin derivative for imaging HSP90 expression in breast cancer.
Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis.
TRMT10C-mediated m7G modification of circFAM126A inhibits lung cancer growth by regulating cellular glycolysis.
Protective role of cytosolic prion protein against virus infection in prion-infected cells.
ATR/Chk1 interacting lncRNA modulates DNA damage response to induce breast cancer chemoresistance.
METTL14-mediated N6-methyladenosine modification of TCP1 mRNA promotes acute myeloid leukemia progression.
SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8(+) T cell activation.
Astrocytic HILPDA promotes lipid droplets generation to drive cognitive dysfunction in mice with sepsis-associated encephalopathy.
Heat shock protein 90 and prolyl hydroxylase 2 co-regulate hypoxia-inducible factor-1α expression in porcine small intestinal epithelial cells under heat stress.
Alnustone promotes megakaryocyte differentiation and platelet production via the interleukin-17A/interleukin-17A receptor/Src/RAC1/MEK/ERK signaling pathway.
Empagliflozin attenuates liver fibrosis in high-fat diet/streptozotocin-induced mice by modulating gut microbiota.
Integrated Metabolomic and transcriptomic analyses reveal deoxycholic acid promotes transmissible gastroenteritis virus infection by inhibiting phosphorylation of NF-κB and STAT3.
The Metabolic Pathway of Bile Secretion Is Vulnerable to Salmonella enterica Exposure in Porcine Intestinal Epithelial Cells.
Trimethylamine N-oxide impairs β-cell function and glucose tolerance.
DUB3 is a MAGEA3 deubiquitinase and a potential therapeutic target in hepatocellular carcinoma.
Nomograms incorporating hsa_circ_0029325 highly expressed in exosomes of hepatocellular carcinoma predict the postoperative outcomes.
Synergistic action of gemcitabine and celecoxib in promoting the antitumor efficacy of anti-programmed death-1 monoclonal antibody by triggering immunogenic cell death.
Quercetin attenuates inflammation in rosacea by directly targeting p65 and ICAM-1.
Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling Pathway.
Hsp90 β is critical for the infection of severe fever with thrombocytopenia syndrome virus.
DNA ligase III mediates deoxynivalenol exposure-induced DNA damage in intestinal epithelial cells by regulating oxidative stress and interaction with PCNA.
Mitochondrial HKDC1 suppresses oxidative stress and apoptosis by regulating mitochondrial function in goose fatty liver.
Intestinal epithelial cell NCoR deficiency ameliorates obesity and metabolic syndrome.
Development of Novel Silicon-Based Hydrophobic Tags (SiHyT) for Targeted Proteins Degradation.
Mesenchymal stem cell-derived exosomes ameliorate hypoxic pulmonary hypertension by inhibiting the Hsp90aa1/ERK/pERK pathway.
Hsp90α promotes chemoresistance in pancreatic cancer by regulating Keap1-Nrf2 axis and inhibiting ferroptosis.
GL-V9 synergizes with oxaliplatin of colorectal cancer via Wee1 degradation mediated by HSP90 inhibition.
Bombinin-BO1 induces hepatocellular carcinoma cell-cycle arrest and apoptosis via the HSP90A-Cdc37-CDK1 axis.
Microbial imidazole propionate affects glomerular filtration rate in patients with diabetic nephropathy through association with HSP90α.
microRNAs profiling of small extracellular vesicles from midbrain tissue of Parkinson's disease.
CD24 May Serve as an Immunotherapy Target in Triple-Negative Breast Cancer by Regulating the Expression of PD-L1.
AKIP1 accelerates glioblastoma progression through stabilizing EGFR expression.
Integrative analysis of miRNA in cartilage-derived extracellular vesicles and single-cell RNA-seq profiles in knee osteoarthritis.
Proteome census upon nutrient stress reveals Golgiphagy membrane receptors.
Nuclear import carrier Hikeshi cooperates with HSP70 to promote murine oligodendrocyte differentiation and CNS myelination.
A High-Fat Diet Increases the Characteristics of Gut Microbial Composition and the Intestinal Damage Associated with Non-Alcoholic Fatty Liver Disease.
Combinatorial selective ER-phagy remodels the ER during neurogenesis.
Mesenchymal stem cells ameliorate cisplatin-induced acute kidney injury via let-7b-5p.
STAU1 promotes adipogenesis by regulating the alternative splicing of Pparγ2 mRNA.
KK-LC-1 as a therapeutic target to eliminate ALDH(+) stem cells in triple negative breast cancer.
A curcumin analogue GO-Y030 depletes cancer stem cells by inhibiting the interaction between the HSP70/HSP40 complex and its substrates.
9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3β and HSP90β.
Exosome miRNAs profiling in serum and prognostic evaluation in patients with multiple myeloma.
QHRD106 ameliorates ischemic stroke injury as a long-acting tissue kallikrein preparation.
Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer.
SIRT2 promotes cell proliferation and migration through mediating ERK1/2 activation and lactosylceramide accumulation in prostate cancer.
Inhibition of EZH2 Causes Retrotransposon Derepression and Immune Activation in Porcine Lung Alveolar Macrophages.
Targeted Protein Degradation Induced by HEMTACs Based on HSP90.
HOXC11 drives lung adenocarcinoma progression through transcriptional regulation of SPHK1.
RNA m5C methylation orchestrates BLCA progression via macrophage reprogramming.
E2F2 modulates cell adhesion through the transcriptional regulation of PECAM1 in multiple myeloma.
Bone Marrow Mesenchymal Stem Cell-Derived Dermcidin-Containing Migrasomes enhance LC3-Associated Phagocytosis of Pulmonary Macrophages and Protect against Post-Stroke Pneumonia.
Precise pancreatic cancer therapy through targeted degradation of mutant p53 protein by cerium oxide nanoparticles.
Curcumin Suppresses the Progression of Colorectal Cancer by Improving Immunogenic Cell Death Caused by Irinotecan.
ATF4/MYC Regulates MTHFD2 to Promote NSCLC Progression by Mediating Redox Homeostasis.
The potential role of exosomal miRNAs and membrane proteins in acute HIV-infected people.
Identification of a novel pyridine derivative with inhibitory activity against ovarian cancer progression in vivo and in vitro.
PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity.
Insulin induces insulin receptor degradation in the liver through EphB4.
Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.
NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma.
Histone Methyltransferase MLL1 Mediates Oxidative Stress and Apoptosis upon Deoxynivalenol Exposure in the Intestinal Porcine Epithelial Cells.
Effect and Mechanism Analysis of Pig FUT8 Gene on Resistance to Escherichia coli F18 Infection.
Independent effects of Src kinase and podoplanin on anchorage independent cell growth and migration.
Genome-wide transcriptional profiling and functional analysis reveal miR-330-MAPK15 axis involving in cellular responses to deoxynivalenol exposure.
Adtrp regulates thermogenic activity of adipose tissue via mediating the secretion of S100b.
Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells.
Cold Stress Induced Liver Injury of Mice through Activated NLRP3/Caspase-1/GSDMD Pyroptosis Signaling Pathway.
Plasma extracellular vesicle microRNA profiling and the identification of a diagnostic signature for stage I lung adenocarcinoma.
Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma.
Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis.
Targeted inhibition of ubiquitin signaling reverses metabolic reprogramming and suppresses glioblastoma growth.
Occludin facilitates tumour angiogenesis in bladder cancer by regulating IL8/STAT3 through STAT4.
Plasma extracellular vesicle long RNA profiling identifies a diagnostic signature for stage I lung adenocarcinoma.
MCMBP promotes the assembly of the MCM2-7 hetero-hexamer to ensure robust DNA replication in human cells.
Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.
The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice.
YAP drives fate conversion and chemoresistance of small cell lung cancer.
Chromatin Accessibility and Transcriptomic Alterations in Murine Ovarian Granulosa Cells upon Deoxynivalenol Exposure.
Melatonin Ameliorates the Toxicity Induced by Deoxynivalenol in Murine Ovary Granulosa Cells by Antioxidative and Anti-Inflammatory Effects.
Effects of temperature on proliferation of myoblasts from donor piglets with different thermoregulatory maturities.
The E3 Ubiquitin Ligase RNF5 Facilitates SARS-CoV-2 Membrane Protein-Mediated Virion Release.
(20S) Ginsenoside Rh2 Exerts Its Anti-Tumor Effect by Disrupting the HSP90A-Cdc37 System in Human Liver Cancer Cells.
Elevated matrix metalloproteinase-9 levels in neuronal extracellular vesicles in Alzheimer's disease.
MSC-derived exosomes promote recovery from traumatic brain injury via microglia/macrophages in rat.
Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation.
PES1 is a critical component of telomerase assembly and regulates cellular senescence.
PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma.
Inhibition of Heat Shock Protein 90 by 17-AAG Reduces Inflammation via P2X7 Receptor/NLRP3 Inflammasome Pathway and Increases Neurogenesis After Subarachnoid Hemorrhage in Mice.
Four new antitumor metabolites isolated from a mutant 3-f-31 strain derived from Penicillium purpurogenum G59.
Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation.
The LIS1/NDE1 Complex Is Essential for FGF Signaling by Regulating FGF Receptor Intracellular Trafficking.
DExD/H-Box Helicase 36 Signaling via Myeloid Differentiation Primary Response Gene 88 Contributes to NF-κB Activation to Type 2 Porcine Reproductive and Respiratory Syndrome Virus Infection.
Motile hepatocellular carcinoma cells preferentially secret sugar metabolism regulatory proteins via exosomes.
Isoform composition and gene expression of thick and thin filament proteins in striated muscles of mice after 30-day space flight.
Xu Z, Yang Z, Lv L, Yang J, Liu W
Journal of medicinal chemistry 2026 May 14;69(9):10811-10827
Journal of medicinal chemistry 2026 May 14;69(9):10811-10827
The HSP90-dependent bioorthogonal PROTAC prodrug system enables tumor-selective and enhanced protein degradation.
Yin F, Song T, Song Y, Wang K, Zhang H, Jiang M, Wang Z, Fan X, Zhang Y, Wang S, Teng Y, Lun H, Wang S, Xie A, Wang Z, Zhang Z
Journal of controlled release : official journal of the Controlled Release Society 2026 May 10;393:114828
Journal of controlled release : official journal of the Controlled Release Society 2026 May 10;393:114828
Exercise training alleviates myocardial injury in mice with heart failure with preserved ejection fraction via the TLR4-mediated necroptosis pathway.
Dong J, Wang H, Feng Y, Jiang X, Yin Y, Zhang E, Wang C, Xing J
International immunopharmacology 2026 May 1;176:116513
International immunopharmacology 2026 May 1;176:116513
BMSC-derived extracellular vesicles enhance osteosarcoma proliferation and metastasis via the circRNA-0010220/β-catenin pathway.
Pan R, Pan Y, Ruan W, Zheng H, Jiang G, Li J, Tian X, Sun L
Cell death & disease 2026 Mar 25;17(1)
Cell death & disease 2026 Mar 25;17(1)
Betaine-homocysteine methyltransferase protects against acetaminophen-induced acute liver failure via BACH1-SCD1-oleic acid axis.
Zhang YT, Yang XM, Jin QS, Chen JY, Zhu NB, Ju Y, Lin ZY, Zhi Y, Dong YN, Li CM, Mao YM, Zhi XL, Ma MY, Xu YL, Li XB
Acta pharmacologica Sinica 2026 Jan;47(1):119-134
Acta pharmacologica Sinica 2026 Jan;47(1):119-134
O-GlcNAcylation of AMFR stabilizes TSPAN4 to regulate migrasome formation for viral release.
Yu L, Li J, Han Y, Yang X, Fu Y, Zhang W, Jiu Y, Cheng L, Ding B
Nature communications 2026 Jan 7;17(1):1506
Nature communications 2026 Jan 7;17(1):1506
SLC38A1 Inhibits Ferroptosis of Alveolar Type II Epithelial Cells in Acute Lung Injury by Promoting Autophagic Degradation of Divalent Metal Transporter 1 (DMT1): an In Vivo and In Vitro Study.
Su F, Yan X, Li X, Zeng B, Sun X, Huang C, Chen C, Li S, Chen Y
Inflammation 2026 Jan 3;49(1):25
Inflammation 2026 Jan 3;49(1):25
Partial embryo loss caused by disruption of the placental hormone CTRP6 coincides with dNK cell abnormalities during pregnancy.
Fan H, Chen X, Du C, Chen S, Yu W, Tang Y, Wang Y, Wang H, Bao W, Cao B, Sun MA
iScience 2026 Jan 16;29(1):114434
iScience 2026 Jan 16;29(1):114434
Combination of GLP-1 receptor agonist and Akkermansia muciniphila Akk11 reduces adiposity and ameliorates MASLD in T2D mice.
Gao K, Yin Z, Zhang C, Dong Z, Wang R, Chen Q, Liu X, Jiang C, Wang Y, Guo B, Zhou Z, Jia Z, Sun H, Feng Y
Cell & bioscience 2026 Jan 12;16(1):18
Cell & bioscience 2026 Jan 12;16(1):18
Nobiletin alleviates heat stress-induced meiotic arrest via restoring CDK1 and MAPK activity in porcine oocytes.
Sim JM, Lee SH, Zhan CL, Lu QY, Lee GH, Song HJ, Jo YJ, Kim JS, Jeung EB, Cui XS
Theriogenology 2026 Jan 1;249:117653
Theriogenology 2026 Jan 1;249:117653
HSP90α facilitates the dephosphorylation of DRP1 at the Ser637 residue, thereby promoting NLRP3 inflammasome activation and exacerbating brain injury in sepsis.
Yang H, Zhou X, Zhang B, Shan Y, Jin Y, Pan E, Xu D, Fan L, Zhao P, Sun Y, Dong J
Free radical biology & medicine 2026 Feb 16;244:45-67
Free radical biology & medicine 2026 Feb 16;244:45-67
Energy stress activates AMPK to arrest mitochondria via phosphorylation of TRAK1.
Falk JE, Henke T, Gowrisankaran S, Wanderoy S, Basu H, Greally S, Steen J, Schwarz TL
The Journal of cell biology 2026 Apr 6;225(4)
The Journal of cell biology 2026 Apr 6;225(4)
Vascular smooth muscle RbFox2 regulates the cytoskeleton and arterial stiffness by a RhoBTB1-Cullin-3 mechanism.
Kumar G, Chaihongsa N, Brozoski DT, Golosova D, Vazirabad I, Lu KT, Wackman KK, Singh RK, Sigmund CD
JCI insight 2026 Apr 2;
JCI insight 2026 Apr 2;
Withaferin-A inhibits colorectal cancer growth and metastasis by targeting the HSP90/HIF-1α/EMT axis.
Lu WQ, Li XD, Gu Y, Huang JM, Qin YK, Cai XY, Wang CM
Archives of medical science : AMS 2025;21(4):1487-1501
Archives of medical science : AMS 2025;21(4):1487-1501
circSLC39A8 by sponging hsa-miR-11181-5p and direct binding to PIK3CA mRNA promotes retinoblastoma proliferation.
Gong J, Song Z, Pan J, Huang X, Feng X, Li Q
Journal of Cancer 2025;16(8):2434-2448
Journal of Cancer 2025;16(8):2434-2448
USP8-Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity.
Zhang Q, Huang S, He Y, Wang W, Tong C, Ma M, Zhao M, Yi L, Knobeloch KP, Zhang P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e03865
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e03865
Integrative Analysis of Metabolome and Transcriptome Identifies the Role of γ-Glutamylcysteine in Mitigating Deoxynivalenol-Induced Toxicity.
Bao X, Chen X, Chen S, Sun MA, Fan H
Toxins 2025 Sep 12;17(9)
Toxins 2025 Sep 12;17(9)
Engineered platelets as targeted protein degraders and application to breast cancer models.
Chen Y, Pal S, Li W, Liu F, Yuan S, Hu Q
Nature biotechnology 2025 Nov;43(11):1800-1812
Nature biotechnology 2025 Nov;43(11):1800-1812
Serine/Threonine Kinase 33 as a Novel Target of Bufalin in Treatment of Triple-Negative Breast Cancer.
Jiang S, Liu J, Li H, Zou C, Wan X, Gong R, Jiang T, Zhong C, Chen Z, Zhu Z, Cao D, Cheng Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(41):e06253
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(41):e06253
HSP70 chaperones IL-33 in chronic airway disease.
Osorio OA, Kluender CE, Raphael HE, Hassan GF, Cohen LS, Steinberg D, Katz-Kiriakos E, Payne MD, Luo EM, Hicks JL, Byers DE, Alexander-Brett J
bioRxiv : the preprint server for biology 2025 Mar 6;
bioRxiv : the preprint server for biology 2025 Mar 6;
Extracellular HSP90-Facilitated Degradation of Extracellular and Membrane Proteins by Bifunctional Small Molecules.
Zhang D, Li J, Liang Y, Li T, Ji M, Liu X, Li W, Chen P, Zhang J, Yang Z, Wang L, Chen H
Journal of medicinal chemistry 2025 Jun 26;68(12):12641-12657
Journal of medicinal chemistry 2025 Jun 26;68(12):12641-12657
STAT3-controlled CHI3L1/SPP1 positive feedback loop demonstrates the spatial heterogeneity and immune characteristics of glioblastoma.
Yu W, Gui S, Peng L, Luo H, Xie J, Xiao J, Yilamu Y, Sun Y, Cai S, Cheng Z, Tao Z
Developmental cell 2025 Jun 23;60(12):1751-1767.e9
Developmental cell 2025 Jun 23;60(12):1751-1767.e9
Depletion of Fat Mass and Obesity-Associated Protein (FTO) Drives Heterochromatin Loss via Lysine Acetyltransferase 8 (KAT8)-Mediated Remodeling and Spacing Factor 1 (RSF1) Acetylation in Skin Aging.
Wang F, Zhou L, Zhong Y, Cai Y, Meng X, Chen M, Mao R, Xiao X, Yi C, Guo Y, Xie H, Zhang Y, Li J
MedComm 2025 Jul;6(7):e70205
MedComm 2025 Jul;6(7):e70205
Secreted EMC10 inhibits muscle GLUT4 activity and glucose uptake in mice.
Jin S, Wu W, Liu S, Wang Y, Huang Q, He K, Ni Y, Chen K, Huang J, Liu L, Dai J, Zhan C, Wang X, Guan Y, Blüher M, Wang X
The Journal of biological chemistry 2025 Jul;301(7):110296
The Journal of biological chemistry 2025 Jul;301(7):110296
(124)I-labelled BMSC-Derived Extracellular Vesicles Deliver CRISPR/Cas9 Ribonucleoproteins With a GFP-Reporter System to Inhibit Osteosarcoma Proliferation and Metastasis.
Pan Y, Yang X, Zeng Z, Liu F, Luo J, Shen M, Zhou W, Li J, Jiang G, Sun L, Huang H, Pan R
Journal of extracellular vesicles 2025 Jul;14(7):e70130
Journal of extracellular vesicles 2025 Jul;14(7):e70130
Swimming exercise reduces H-type vessels by down-regulating the Hif-1α/VEGFa pathway in mice with osteoarthritis of the knee.
Huang L, Du W, Jin X, Chen B, Meng Z
BMC musculoskeletal disorders 2025 Jul 5;26(1):657
BMC musculoskeletal disorders 2025 Jul 5;26(1):657
Acetate Administration Ameliorates Streptozotocin-Induced Hyperglycemia and Adipose Tissue Loss.
Zhang C, Wang Z, Luo L, Liu X, Jia Z, Zhang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 31;39(14):e70855
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 31;39(14):e70855
Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis.
Liu L, Ma Y, Jian Z, Liao B, Li Y, Lin L, Wang M, Chen J, Wei J, Yang M, Liu Y, Yuan Y, Wen J, Xiang L, Qi S, Jin X, Wang K
Cell reports 2025 Jul 22;44(7):115936
Cell reports 2025 Jul 22;44(7):115936
Jahn-Teller distortion-engineered self-propelled nanorobots for mitochondrial targeting and bioenergetic disruption in tumor therapy.
Luo T, Zhang M, Xu J, Yuan D, Yin B, Zhu Y, Yan S, Pan M, Mo D, Li X, Liang X, Qin Z, Deng H, Qian Z
Bioactive materials 2025 Dec;54:273-290
Bioactive materials 2025 Dec;54:273-290
PSPC1-SMAD3 axis regulates iron-induced beiging of adipocytes in white adipose tissue.
Peng XM, He R, Wang HY, Liu JD, Xie YY, Wang ZH, Deng HY, Wang WS, Zhu ZZ, Ge J, Liu YL, Gao RH, Yang M, Li DP, Kang QQ, Pan RP, Chen Y
Cell communication and signaling : CCS 2025 Dec 4;24(1):12
Cell communication and signaling : CCS 2025 Dec 4;24(1):12
Identification of the Role of NAT10 in the Regulation of Porcine Circovirus Type 2 Infection.
Liu Y, Zhou G, Wang G, Wu Z
Veterinary sciences 2025 Dec 4;12(12)
Veterinary sciences 2025 Dec 4;12(12)
The C1QTNF6-MX2 Antiviral Axis Inhibits Porcine Circovirus Type 2 Replication in Porcine Macrophages.
Chen X, Jiang J, Bao X, Xu C, Chen S, Wu Z, Wang H, Fan H, Bao W
Veterinary sciences 2025 Dec 21;13(1)
Veterinary sciences 2025 Dec 21;13(1)
Aurora A degradation by HSP90 interactome-mediating PROTACs in A549 and paclitaxel-resistant A549 cells.
Deng XY, Xu H, Peng YX, Guo YY, He RF, Lu G
European journal of medicinal chemistry 2025 Dec 15;300:118141
European journal of medicinal chemistry 2025 Dec 15;300:118141
Upregulating mTOR/S6 K Pathway by CASTOR1 Promotes Astrocyte Proliferation and Myelination in Gpam(-/-)-induced mouse model of cerebral palsy.
Chen Z, Liu L, Guo X, Zhang Y, Zhong M, Xu Y, Peng T Sr, Peng T Jr, Zhang Y, Hou Q, Fan D, Gao T, He L, Tang H, Hu H, Xu K
Molecular neurobiology 2025 Aug;62(8):10724-10741
Molecular neurobiology 2025 Aug;62(8):10724-10741
Upregulation of E3 ligase UBR2 in acetaldehyde-treated C2C12 myotubes and its potential involvement in fast-twitch muscle atrophy in alcohol-fed rats.
Shintani-Ishida K, Ikegaya H
Alcohol, clinical & experimental research 2025 Aug;49(8):1667-1677
Alcohol, clinical & experimental research 2025 Aug;49(8):1667-1677
Downregulated TFPI2 Accelerates Skin Aging by Repressing the Cell Cycle through Phosphoinositide 3-Kinase/Protein Kinase B/CDC6 Pathway.
Wang F, Yi C, Zhong Y, Zhou L, Meng X, Mao R, Guo Y, Xie H, Zhang Y, Huang Y, Li J
The Journal of investigative dermatology 2025 Aug;145(8):1910-1920.e7
The Journal of investigative dermatology 2025 Aug;145(8):1910-1920.e7
HSP70 is a chaperone for IL-33 activity in chronic airway disease.
Osorio OA, Raphael HE, Kluender CE, Hassan GF, Cohen LS, Steinberg DF, Katz-Kiriakos E, Payne MD, Luo EM, Hicks JL, Byers DE, Alexander-Brett J
JCI insight 2025 Aug 8;10(15)
JCI insight 2025 Aug 8;10(15)
Constraint-induced movement therapy combined with mesenchymal stem cell transplantation promotes myelination and functional recovery by inhibiting PRKCD/MEK/ERK pathway in hemiplegic cerebral palsy rats.
Guo X, Liu L, Luo J, Peng T Jr, Wang Y, Huang S, Zeng X, Peng T Sr, Chen A, Zhong M, Zhang Y, Xu K, He L
Stem cell research & therapy 2025 Aug 21;16(1):447
Stem cell research & therapy 2025 Aug 21;16(1):447
Analysis of the Role of KLF4 in the Regulation of Porcine Epidemic Diarrhea Virus Infection.
Wang H, Zhou Y, Gu S, Feng M, Wang J, Jin J, Huang X, Wu S, Bao W
Animals : an open access journal from MDPI 2025 Aug 11;15(16)
Animals : an open access journal from MDPI 2025 Aug 11;15(16)
p23 protects against ferroptosis of brain microvascular endothelial cells in ischemic stroke.
Zhao Y, Xu Y, Xu Q, He N, Zhao J, Liu Y
International journal of molecular medicine 2025 Apr;55(4)
International journal of molecular medicine 2025 Apr;55(4)
Isoforskolin, adenylate cyclase agonist, inhibits endothelial-to-mesenchymal transition in atherosclerosis.
Ma Y, Shi Y, Lun J, Wang M, Zhang C, Li X, Yi Q, Cao X, Hu Z, Yang W, Cai H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156520
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156520
Systematic pharmacology-based strategy to investigate the mechanism of beta-sitosterol for the treatment of rheumarthritis.
Wang X, Mao J
Frontiers in genetics 2024;15:1507606
Frontiers in genetics 2024;15:1507606
G-Protein-Coupled Receptor Kinase 2 Inhibition Induces Meiotic Arrest by Disturbing Ca(2+) Release in Porcine Oocytes.
Kim JD, Lee SH, Li XH, Lu QY, Zhan CL, Lee GH, Sim JM, Song HJ, Zhou D, Cui XS
Reproduction in domestic animals = Zuchthygiene 2024 Sep;59(9):e14715
Reproduction in domestic animals = Zuchthygiene 2024 Sep;59(9):e14715
Synthesis and characterization of (64)Cu-labeled Geldanamycin derivative for imaging HSP90 expression in breast cancer.
Li F, Fan Y, Zhou L, Martin DR, Liu Z, Li Z
Nuclear medicine and biology 2024 Sep-Oct;136-137:108929
Nuclear medicine and biology 2024 Sep-Oct;136-137:108929
Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis.
Dong J, Ma F, Cai M, Cao F, Li H, Liang H, Li Y, Ding G, Li J, Cheng X, Qin JJ
Journal of medicinal chemistry 2024 Sep 26;67(18):16712-16736
Journal of medicinal chemistry 2024 Sep 26;67(18):16712-16736
TRMT10C-mediated m7G modification of circFAM126A inhibits lung cancer growth by regulating cellular glycolysis.
Zhao Q, Li X, Wu J, Zhang R, Chen S, Cai D, Xu H, Peng W, Li G, Nan A
Cell biology and toxicology 2024 Sep 18;40(1):78
Cell biology and toxicology 2024 Sep 18;40(1):78
Protective role of cytosolic prion protein against virus infection in prion-infected cells.
Hara H, Chida J, Batchuluun B, Takahashi E, Kido H, Sakaguchi S
Journal of virology 2024 Sep 17;98(9):e0126224
Journal of virology 2024 Sep 17;98(9):e0126224
ATR/Chk1 interacting lncRNA modulates DNA damage response to induce breast cancer chemoresistance.
Luo R, Wu J, Chen X, Liu Y, Liu D, Song E, Luo ML
Cell insight 2024 Oct;3(5):100183
Cell insight 2024 Oct;3(5):100183
METTL14-mediated N6-methyladenosine modification of TCP1 mRNA promotes acute myeloid leukemia progression.
Zhang M, Xie Z, Tan Y, Wu Y, Wang M, Zhang P, Yuan Y, Li J
Cellular signalling 2024 Oct;122:111304
Cellular signalling 2024 Oct;122:111304
SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8(+) T cell activation.
Liu W, You D, Lin J, Zou H, Zhang L, Luo S, Yuan Y, Wang Z, Qi J, Wang W, Ye X, Yang X, Deng Y, Teng F, Zheng X, Lin Y, Huang Z, Huang Y, Yang Z, Zhou X, Zhang Y, Chen R, Xu L, Li J, Yang W, Zhang H
Cell metabolism 2024 Oct 1;36(10):2245-2261.e6
Cell metabolism 2024 Oct 1;36(10):2245-2261.e6
Astrocytic HILPDA promotes lipid droplets generation to drive cognitive dysfunction in mice with sepsis-associated encephalopathy.
Li L, Lixia D, Gan G, Li J, Yang L, Wu Y, Fang Z, Zhang X
CNS neuroscience & therapeutics 2024 May;30(5):e14758
CNS neuroscience & therapeutics 2024 May;30(5):e14758
Heat shock protein 90 and prolyl hydroxylase 2 co-regulate hypoxia-inducible factor-1α expression in porcine small intestinal epithelial cells under heat stress.
Liu Y, Fan G, Zhang G, Xiong Y, Li H
Journal of thermal biology 2024 May;122:103881
Journal of thermal biology 2024 May;122:103881
Alnustone promotes megakaryocyte differentiation and platelet production via the interleukin-17A/interleukin-17A receptor/Src/RAC1/MEK/ERK signaling pathway.
Li Y, Lai J, Ran M, Yi T, Zhou L, Luo J, Liu X, Tang X, Huang M, Xie X, Li H, Yang Y, Zou W, Wu J
European journal of pharmacology 2024 May 15;971:176548
European journal of pharmacology 2024 May 15;971:176548
Empagliflozin attenuates liver fibrosis in high-fat diet/streptozotocin-induced mice by modulating gut microbiota.
Huang C, Qian J, Liu Y, Zhang L, Yang Y
Clinical and experimental pharmacology & physiology 2024 Mar;51(3):e13842
Clinical and experimental pharmacology & physiology 2024 Mar;51(3):e13842
Integrated Metabolomic and transcriptomic analyses reveal deoxycholic acid promotes transmissible gastroenteritis virus infection by inhibiting phosphorylation of NF-κB and STAT3.
Zhou Y, Xu C, Gu S, Xiao Y, Wu S, Wang H, Bao W
BMC genomics 2024 Mar 4;25(1):239
BMC genomics 2024 Mar 4;25(1):239
The Metabolic Pathway of Bile Secretion Is Vulnerable to Salmonella enterica Exposure in Porcine Intestinal Epithelial Cells.
Cai J, Chen X, Xu C, Zhu X, Wang H, Wu S, Cai D, Fan H
Animals : an open access journal from MDPI 2024 Mar 3;14(5)
Animals : an open access journal from MDPI 2024 Mar 3;14(5)
Trimethylamine N-oxide impairs β-cell function and glucose tolerance.
Kong L, Zhao Q, Jiang X, Hu J, Jiang Q, Sheng L, Peng X, Wang S, Chen Y, Wan Y, Hou S, Liu X, Ma C, Li Y, Quan L, Chen L, Cui B, Li P
Nature communications 2024 Mar 21;15(1):2526
Nature communications 2024 Mar 21;15(1):2526
DUB3 is a MAGEA3 deubiquitinase and a potential therapeutic target in hepatocellular carcinoma.
Chen Y, Gao F, He Y, Liu M, Quan Y, Zhang P
iScience 2024 Mar 15;27(3):109181
iScience 2024 Mar 15;27(3):109181
Nomograms incorporating hsa_circ_0029325 highly expressed in exosomes of hepatocellular carcinoma predict the postoperative outcomes.
Yin KL, Sun T, Duan YX, Ye WT, Ming Li, Liao R
Discover oncology 2024 Jun 5;15(1):212
Discover oncology 2024 Jun 5;15(1):212
Synergistic action of gemcitabine and celecoxib in promoting the antitumor efficacy of anti-programmed death-1 monoclonal antibody by triggering immunogenic cell death.
Zhu X, Zhang W, Yu Z, Yang X, Li L, Chen C, Djumanazarov T, Piquemal D, Yusupbekov AA, Zheng Y
Translational cancer research 2024 Jun 30;13(6):3031-3045
Translational cancer research 2024 Jun 30;13(6):3031-3045
Quercetin attenuates inflammation in rosacea by directly targeting p65 and ICAM-1.
Meng X, Li Y, Wang F, Li T, Wang B, Wang Q, Long J, Xie H, Zhang Y, Li J
Life sciences 2024 Jun 15;347:122675
Life sciences 2024 Jun 15;347:122675
Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling Pathway.
Song Y, Li H, Lian R, Dou X, Li S, Xie J, Li X, Feng R, Li Z
Viruses 2024 Jan 24;16(2)
Viruses 2024 Jan 24;16(2)
Hsp90 β is critical for the infection of severe fever with thrombocytopenia syndrome virus.
Wang B, Zhang L, Deng F, Hu Z, Wang M, Liu J
Virologica Sinica 2024 Feb;39(1):113-122
Virologica Sinica 2024 Feb;39(1):113-122
DNA ligase III mediates deoxynivalenol exposure-induced DNA damage in intestinal epithelial cells by regulating oxidative stress and interaction with PCNA.
Zhu X, Wu J, Chen X, Shi D, Hui P, Wang H, Wu Z, Wu S, Bao W, Fan H
International journal of biological macromolecules 2024 Dec;282(Pt 5):137137
International journal of biological macromolecules 2024 Dec;282(Pt 5):137137
Mitochondrial HKDC1 suppresses oxidative stress and apoptosis by regulating mitochondrial function in goose fatty liver.
Xing Y, Ge J, Wang Y, Zhou X, Yuan Z, Lv M, Zhao M, Liu L, Gong D, Geng T, Xie K
International journal of biological macromolecules 2024 Dec;282(Pt 4):137222
International journal of biological macromolecules 2024 Dec;282(Pt 4):137222
Intestinal epithelial cell NCoR deficiency ameliorates obesity and metabolic syndrome.
Hou S, Yu H, Liu C, Johnson AMF, Liu X, Jiang Q, Zhao Q, Kong L, Wan Y, Xing X, Chen Y, Chen J, Wu Q, Zhang P, Jiang C, Cui B, Li P
Acta pharmaceutica Sinica. B 2024 Dec;14(12):5267-5285
Acta pharmaceutica Sinica. B 2024 Dec;14(12):5267-5285
Development of Novel Silicon-Based Hydrophobic Tags (SiHyT) for Targeted Proteins Degradation.
Ma L, Zhang K, Huang Z, Guo Y, Liu N, Chen J, Wang X, Liu Y, Li M, Li J, Yang C, Liu S, Yang G
Journal of medicinal chemistry 2024 Dec 12;67(23):21344-21363
Journal of medicinal chemistry 2024 Dec 12;67(23):21344-21363
Mesenchymal stem cell-derived exosomes ameliorate hypoxic pulmonary hypertension by inhibiting the Hsp90aa1/ERK/pERK pathway.
Deng ZH, Chen YX, Xue-Gao, Yang JY, Wei XY, Zhang GX, Qian JX
Biochemical pharmacology 2024 Aug;226:116382
Biochemical pharmacology 2024 Aug;226:116382
Hsp90α promotes chemoresistance in pancreatic cancer by regulating Keap1-Nrf2 axis and inhibiting ferroptosis.
Liu B, Chen Z, Li Z, Zhao X, Zhang W, Zhang A, Wen L, Wang X, Zhou S, Qian D
Acta biochimica et biophysica Sinica 2024 Aug 22;57(2):295-309
Acta biochimica et biophysica Sinica 2024 Aug 22;57(2):295-309
GL-V9 synergizes with oxaliplatin of colorectal cancer via Wee1 degradation mediated by HSP90 inhibition.
Chen H, Yang F, Zhao Q, Wang H, Zhu M, Li H, Ge Z, Zhang S, Guo Q, Hui H
The Journal of pharmacy and pharmacology 2024 Aug 2;76(8):1006-1017
The Journal of pharmacy and pharmacology 2024 Aug 2;76(8):1006-1017
Bombinin-BO1 induces hepatocellular carcinoma cell-cycle arrest and apoptosis via the HSP90A-Cdc37-CDK1 axis.
Wang X, Tang P, Gong Y, Yao H, Liang M, Qu H, Han X, Zheng Q, Shi Z, Li D, Jiang Q
iScience 2024 Aug 16;27(8):110382
iScience 2024 Aug 16;27(8):110382
Microbial imidazole propionate affects glomerular filtration rate in patients with diabetic nephropathy through association with HSP90α.
Lv D, Zheng W, Zhang Z, Lin Z, Wu K, Liu H, Liao X, Sun Y
Biochimica et biophysica acta. Molecular cell research 2024 Apr;1871(4):119703
Biochimica et biophysica acta. Molecular cell research 2024 Apr;1871(4):119703
microRNAs profiling of small extracellular vesicles from midbrain tissue of Parkinson's disease.
Li Z, Chen D, Pan R, Zhong Y, Zhong T, Jiao Z
Frontiers in molecular neuroscience 2023;16:1090556
Frontiers in molecular neuroscience 2023;16:1090556
CD24 May Serve as an Immunotherapy Target in Triple-Negative Breast Cancer by Regulating the Expression of PD-L1.
Zhu X, Yu J, Ai F, Wang Y, Lv W, Yu G, Cao X, Lin J
Breast cancer (Dove Medical Press) 2023;15:967-984
Breast cancer (Dove Medical Press) 2023;15:967-984
AKIP1 accelerates glioblastoma progression through stabilizing EGFR expression.
Wan S, Liu C, Li C, Wang Z, Zhao G, Li J, Ran W, Zhong X, Li Y, Zhang L, Cui H
Oncogene 2023 Sep;42(39):2905-2918
Oncogene 2023 Sep;42(39):2905-2918
Integrative analysis of miRNA in cartilage-derived extracellular vesicles and single-cell RNA-seq profiles in knee osteoarthritis.
Ning Y, Zhang F, Li S, Wang C, Wu Y, Chen S, Liu Y, Chen F, Guo X, Wang X, Zhao H
Archives of biochemistry and biophysics 2023 Oct 15;748:109785
Archives of biochemistry and biophysics 2023 Oct 15;748:109785
Proteome census upon nutrient stress reveals Golgiphagy membrane receptors.
Hickey KL, Swarup S, Smith IR, Paoli JC, Miguel Whelan E, Paulo JA, Harper JW
Nature 2023 Nov;623(7985):167-174
Nature 2023 Nov;623(7985):167-174
Nuclear import carrier Hikeshi cooperates with HSP70 to promote murine oligodendrocyte differentiation and CNS myelination.
Li L, Li D, Sun D, Zhang X, Lei W, Wu M, Huang Q, Nian X, Dai W, Lu X, Zhou Z, Zhu Y, Xiao Y, Zhang L, Mo W, Liu Z, Zhang L
Developmental cell 2023 Nov 6;58(21):2275-2291.e6
Developmental cell 2023 Nov 6;58(21):2275-2291.e6
A High-Fat Diet Increases the Characteristics of Gut Microbial Composition and the Intestinal Damage Associated with Non-Alcoholic Fatty Liver Disease.
Zhu X, Cai J, Wang Y, Liu X, Chen X, Wang H, Wu Z, Bao W, Fan H, Wu S
International journal of molecular sciences 2023 Nov 24;24(23)
International journal of molecular sciences 2023 Nov 24;24(23)
Combinatorial selective ER-phagy remodels the ER during neurogenesis.
Hoyer MJ, Capitanio C, Smith IR, Paoli JC, Bieber A, Jiang Y, Paulo JA, Gonzalez-Lozano MA, Baumeister W, Wilfling F, Schulman BA, Harper JW
bioRxiv : the preprint server for biology 2023 Nov 10;
bioRxiv : the preprint server for biology 2023 Nov 10;
Mesenchymal stem cells ameliorate cisplatin-induced acute kidney injury via let-7b-5p.
Wang SY, Xu Y, Hong Q, Chen XM, Cai GY
Cell and tissue research 2023 May;392(2):517-533
Cell and tissue research 2023 May;392(2):517-533
STAU1 promotes adipogenesis by regulating the alternative splicing of Pparγ2 mRNA.
Jiang S, Meng X, Gu H, Sun J, Chen S, Chen Z, Liu D, Liang X
Biochimica et biophysica acta. Molecular and cell biology of lipids 2023 May;1868(5):159293
Biochimica et biophysica acta. Molecular and cell biology of lipids 2023 May;1868(5):159293
KK-LC-1 as a therapeutic target to eliminate ALDH(+) stem cells in triple negative breast cancer.
Bu J, Zhang Y, Wu S, Li H, Sun L, Liu Y, Zhu X, Qiao X, Ma Q, Liu C, Niu N, Xue J, Chen G, Yang Y, Liu C
Nature communications 2023 May 5;14(1):2602
Nature communications 2023 May 5;14(1):2602
A curcumin analogue GO-Y030 depletes cancer stem cells by inhibiting the interaction between the HSP70/HSP40 complex and its substrates.
Suzuki M, Yamamoto Y, Nishijima-Matsunobu A, Kawasaki Y, Shibata H, Omori Y
FEBS open bio 2023 Mar;13(3):434-446
FEBS open bio 2023 Mar;13(3):434-446
9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3β and HSP90β.
Wang C, Wang T, Hu R, Duan L, Hou Q, Han Y, Dai J, Wang W, Ren S, Liu H, Wang X, Xiao S, Li N, Wang J, Yang Z
Journal of virology 2023 Mar 30;97(3):e0198422
Journal of virology 2023 Mar 30;97(3):e0198422
Exosome miRNAs profiling in serum and prognostic evaluation in patients with multiple myeloma.
Fang T, Sun H, Sun X, He Y, Tang P, Gong L, Yu Z, Liu L, Xie S, Wang T, Xu Z, Yi S, An G, Xu Y, Zhu G, Qiu L, Hao M
Blood science (Baltimore, Md.) 2023 Jul;5(3):196-208
Blood science (Baltimore, Md.) 2023 Jul;5(3):196-208
QHRD106 ameliorates ischemic stroke injury as a long-acting tissue kallikrein preparation.
Xu SY, Jia JQ, Sun M, Bao XY, Xia SN, Shu S, Liu PY, Ji SL, Ye L, Cao X, Xu Y
iScience 2023 Jul 21;26(7):107268
iScience 2023 Jul 21;26(7):107268
Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer.
Zhang Y, Fan A, Li Y, Liu Z, Yu L, Guo J, Hou J, Li X, Chen W
Cancer letters 2023 Jul 10;566:216244
Cancer letters 2023 Jul 10;566:216244
SIRT2 promotes cell proliferation and migration through mediating ERK1/2 activation and lactosylceramide accumulation in prostate cancer.
Lin R, Yang Y, Wu E, Zhou M, Wang S, Zhang Q
The Prostate 2023 Jan;83(1):71-81
The Prostate 2023 Jan;83(1):71-81
Inhibition of EZH2 Causes Retrotransposon Derepression and Immune Activation in Porcine Lung Alveolar Macrophages.
Zhang L, Jin J, Qin W, Jiang J, Bao W, Sun MA
International journal of molecular sciences 2023 Jan 25;24(3)
International journal of molecular sciences 2023 Jan 25;24(3)
Targeted Protein Degradation Induced by HEMTACs Based on HSP90.
Li Z, Ma S, Zhang L, Zhang S, Ma Z, Du L, Li M
Journal of medicinal chemistry 2023 Jan 12;66(1):733-751
Journal of medicinal chemistry 2023 Jan 12;66(1):733-751
HOXC11 drives lung adenocarcinoma progression through transcriptional regulation of SPHK1.
Peng X, Liu X, Hu W, Zhou Y, Ouyang L, Peng X, Long Y, Sun J, Tao T, Chen L, Shi Y, Tao Y, Xiao D, Liu S
Cell death & disease 2023 Feb 23;14(2):153
Cell death & disease 2023 Feb 23;14(2):153
RNA m5C methylation orchestrates BLCA progression via macrophage reprogramming.
Yan D, Xie Y, Huang L, Zhang Y, Gu R, Xie H, Huang X, Luo H
Journal of cellular and molecular medicine 2023 Aug;27(16):2398-2411
Journal of cellular and molecular medicine 2023 Aug;27(16):2398-2411
E2F2 modulates cell adhesion through the transcriptional regulation of PECAM1 in multiple myeloma.
Chen SN, Mai ZY, Mai JN, Liang W, Dong ZX, Ju FE, Chan SH, Fang Z, Xu Y, Uziel O, He C, Zhang XD, Zheng Y
British journal of haematology 2023 Aug;202(4):840-855
British journal of haematology 2023 Aug;202(4):840-855
Bone Marrow Mesenchymal Stem Cell-Derived Dermcidin-Containing Migrasomes enhance LC3-Associated Phagocytosis of Pulmonary Macrophages and Protect against Post-Stroke Pneumonia.
Li T, Su X, Lu P, Kang X, Hu M, Li C, Wang S, Lu D, Shen S, Huang H, Liu Y, Deng X, Cai W, Wei L, Lu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Aug;10(22):e2206432
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Aug;10(22):e2206432
Precise pancreatic cancer therapy through targeted degradation of mutant p53 protein by cerium oxide nanoparticles.
Zhang H, Zhang W, Hu B, Qin X, Yi T, Ye Y, Huang X, Song Y, Yang Z, Qian J, Zhang Y
Journal of nanobiotechnology 2023 Apr 1;21(1):117
Journal of nanobiotechnology 2023 Apr 1;21(1):117
Curcumin Suppresses the Progression of Colorectal Cancer by Improving Immunogenic Cell Death Caused by Irinotecan.
Zhu C, Fang Z, Peng L, Gao F, Peng W, Song F
Chemotherapy 2022;67(4):211-222
Chemotherapy 2022;67(4):211-222
ATF4/MYC Regulates MTHFD2 to Promote NSCLC Progression by Mediating Redox Homeostasis.
Gao Y, Feng L, Zhang L, Geng J, Zhang E
Disease markers 2022;2022:7527996
Disease markers 2022;2022:7527996
The potential role of exosomal miRNAs and membrane proteins in acute HIV-infected people.
Li X, Wang W, Chen J, Xie B, Luo S, Chen D, Cai C, Li C, Li W
Frontiers in immunology 2022;13:939504
Frontiers in immunology 2022;13:939504
Identification of a novel pyridine derivative with inhibitory activity against ovarian cancer progression in vivo and in vitro.
Si L, Lai T, Zhao J, Jin Y, Qi M, Li M, Fu H, Shi X, Ma L, Guo R
Frontiers in pharmacology 2022;13:1064485
Frontiers in pharmacology 2022;13:1064485
PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity.
Li C, Pan Y, Tan Y, Wang Y, Sun X
Frontiers in cell and developmental biology 2022;10:896014
Frontiers in cell and developmental biology 2022;10:896014
Insulin induces insulin receptor degradation in the liver through EphB4.
Liu X, Wang K, Hou S, Jiang Q, Ma C, Zhao Q, Kong L, Chen J, Wang Z, Zhang H, Yuan T, Li Y, Huan Y, Shen Z, Hu Z, Huang Z, Cui B, Li P
Nature metabolism 2022 Sep;4(9):1202-1213
Nature metabolism 2022 Sep;4(9):1202-1213
Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.
Boland S, Swarup S, Ambaw YA, Malia PC, Richards RC, Fischer AW, Singh S, Aggarwal G, Spina S, Nana AL, Grinberg LT, Seeley WW, Surma MA, Klose C, Paulo JA, Nguyen AD, Harper JW, Walther TC, Farese RV Jr
Nature communications 2022 Oct 7;13(1):5924
Nature communications 2022 Oct 7;13(1):5924
NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma.
Zhan Y, Zhang Z, Liu Y, Fang Y, Xie Y, Zheng Y, Li G, Liang L, Ding Y
BMC medicine 2022 Oct 19;20(1):365
BMC medicine 2022 Oct 19;20(1):365
Histone Methyltransferase MLL1 Mediates Oxidative Stress and Apoptosis upon Deoxynivalenol Exposure in the Intestinal Porcine Epithelial Cells.
Shi D, Shan Y, Zhu X, Wang H, Wu S, Wu Z, Bao W
Antioxidants (Basel, Switzerland) 2022 Oct 11;11(10)
Antioxidants (Basel, Switzerland) 2022 Oct 11;11(10)
Effect and Mechanism Analysis of Pig FUT8 Gene on Resistance to Escherichia coli F18 Infection.
Wu L, Wang Y, Wu S, Wu Z, Bao W
International journal of molecular sciences 2022 Nov 25;23(23)
International journal of molecular sciences 2022 Nov 25;23(23)
Independent effects of Src kinase and podoplanin on anchorage independent cell growth and migration.
Retzbach EP, Sheehan SA, Krishnan H, Zheng H, Zhao C, Goldberg GS
Molecular carcinogenesis 2022 Jul;61(7):677-689
Molecular carcinogenesis 2022 Jul;61(7):677-689
Genome-wide transcriptional profiling and functional analysis reveal miR-330-MAPK15 axis involving in cellular responses to deoxynivalenol exposure.
Wang H, Zhou Y, Xu C, Cao Y, Xiao Y, Cai D, Uemoto Y, Wu S, Bao W
Chemosphere 2022 Jul;298:134199
Chemosphere 2022 Jul;298:134199
Adtrp regulates thermogenic activity of adipose tissue via mediating the secretion of S100b.
Li P, Song R, Du Y, Liu H, Li X
Cellular and molecular life sciences : CMLS 2022 Jul 8;79(8):407
Cellular and molecular life sciences : CMLS 2022 Jul 8;79(8):407
Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells.
Xu D, Ma R, Ju Y, Song X, Niu B, Hong W, Wang R, Yang Q, Zhao Z, Zhang Y, Zheng Y, Bai Q, Lv M, Sun N, Li X
Nature communications 2022 Jul 30;13(1):4428
Nature communications 2022 Jul 30;13(1):4428
Cold Stress Induced Liver Injury of Mice through Activated NLRP3/Caspase-1/GSDMD Pyroptosis Signaling Pathway.
Liu Y, Xue N, Zhang B, Lv H, Li S
Biomolecules 2022 Jul 1;12(7)
Biomolecules 2022 Jul 1;12(7)
Plasma extracellular vesicle microRNA profiling and the identification of a diagnostic signature for stage I lung adenocarcinoma.
Gao S, Guo W, Liu T, Liang N, Ma Q, Gao Y, Tan F, Xue Q, He J
Cancer science 2022 Feb;113(2):648-659
Cancer science 2022 Feb;113(2):648-659
Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma.
Xu Z, Xu J, Sun S, Lin W, Li Y, Lu Q, Li F, Yang Z, Lu Y, Liu W
Redox biology 2022 Aug;54:102351
Redox biology 2022 Aug;54:102351
Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis.
D'Amico D, Olmer M, Fouassier AM, Valdés P, Andreux PA, Rinsch C, Lotz M
Aging cell 2022 Aug;21(8):e13662
Aging cell 2022 Aug;21(8):e13662
Targeted inhibition of ubiquitin signaling reverses metabolic reprogramming and suppresses glioblastoma growth.
Delle Donne R, Iannucci R, Rinaldi L, Roberto L, Oliva MA, Senatore E, Borzacchiello D, Lignitto L, Giurato G, Rizzo F, Sellitto A, Chiuso F, Castaldo S, Scala G, Campani V, Nele V, De Rosa G, D'Ambrosio C, Garbi C, Scaloni A, Weisz A, Ambrosino C, Arcella A, Feliciello A
Communications biology 2022 Aug 2;5(1):780
Communications biology 2022 Aug 2;5(1):780
Occludin facilitates tumour angiogenesis in bladder cancer by regulating IL8/STAT3 through STAT4.
Yang F, Liu XQ, He JZ, Xian SP, Yang PF, Mai ZY, Li M, Liu Y, Zhang XD
Journal of cellular and molecular medicine 2022 Apr;26(8):2363-2376
Journal of cellular and molecular medicine 2022 Apr;26(8):2363-2376
Plasma extracellular vesicle long RNA profiling identifies a diagnostic signature for stage I lung adenocarcinoma.
Guo W, Huai Q, Liu T, Zhang G, Liang N, Ma Q, Liu X, Tan F, Xue Q, Gao S, Gao Y, He J
Translational lung cancer research 2022 Apr;11(4):572-587
Translational lung cancer research 2022 Apr;11(4):572-587
MCMBP promotes the assembly of the MCM2-7 hetero-hexamer to ensure robust DNA replication in human cells.
Saito Y, Santosa V, Ishiguro KI, Kanemaki MT
eLife 2022 Apr 19;11
eLife 2022 Apr 19;11
Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.
Wang CM, Li HF, Wang XK, Li WG, Su Q, Xiao X, Hao TF, Chen W, Zhang YW, Zhang HY, Wu W, Hu ZR, Zhao GY, Huo MY, He YL, Zhang CH
International journal of biological sciences 2021;17(11):2811-2825
International journal of biological sciences 2021;17(11):2811-2825
The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice.
Yu Y, Liu X, Zhao Z, Xu Z, Qiao Y, Zhou Y, Qiao H, Zhong J, Dai J, Suo G
Frontiers in pharmacology 2021;12:747223
Frontiers in pharmacology 2021;12:747223
YAP drives fate conversion and chemoresistance of small cell lung cancer.
Wu Q, Guo J, Liu Y, Zheng Q, Li X, Wu C, Fang D, Chen X, Ma L, Xu P, Xu X, Liao C, Wu M, Shen L, Song H
Science advances 2021 Oct;7(40):eabg1850
Science advances 2021 Oct;7(40):eabg1850
Chromatin Accessibility and Transcriptomic Alterations in Murine Ovarian Granulosa Cells upon Deoxynivalenol Exposure.
Fan H, Ren Z, Xu C, Wang H, Wu Z, Rehman ZU, Wu S, Sun MA, Bao W
Cells 2021 Oct 20;10(11)
Cells 2021 Oct 20;10(11)
Melatonin Ameliorates the Toxicity Induced by Deoxynivalenol in Murine Ovary Granulosa Cells by Antioxidative and Anti-Inflammatory Effects.
Fan H, Wang S, Wang H, Sun M, Wu S, Bao W
Antioxidants (Basel, Switzerland) 2021 Jun 29;10(7)
Antioxidants (Basel, Switzerland) 2021 Jun 29;10(7)
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BMC molecular and cell biology 2021 Jun 26;22(1):36
BMC molecular and cell biology 2021 Jun 26;22(1):36
The E3 Ubiquitin Ligase RNF5 Facilitates SARS-CoV-2 Membrane Protein-Mediated Virion Release.
Yuan Z, Hu B, Xiao H, Tan X, Li Y, Tang K, Zhang Y, Cai K, Ding B
mBio 2021 Feb 22;13(1):e0316821
mBio 2021 Feb 22;13(1):e0316821
(20S) Ginsenoside Rh2 Exerts Its Anti-Tumor Effect by Disrupting the HSP90A-Cdc37 System in Human Liver Cancer Cells.
Chen C, Wang YS, Zhang ET, Li GA, Liu WY, Li Y, Jin YH
International journal of molecular sciences 2021 Dec 6;22(23)
International journal of molecular sciences 2021 Dec 6;22(23)
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Annals of clinical and translational neurology 2020 Sep;7(9):1681-1691
Annals of clinical and translational neurology 2020 Sep;7(9):1681-1691
MSC-derived exosomes promote recovery from traumatic brain injury via microglia/macrophages in rat.
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Molecular cancer 2020 Jun 29;19(1):112
Molecular cancer 2020 Jun 29;19(1):112
PES1 is a critical component of telomerase assembly and regulates cellular senescence.
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Science advances 2019 May;5(5):eaav1090
Science advances 2019 May;5(5):eaav1090
PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma.
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Journal of experimental & clinical cancer research : CR 2019 May 17;38(1):204
Inhibition of Heat Shock Protein 90 by 17-AAG Reduces Inflammation via P2X7 Receptor/NLRP3 Inflammasome Pathway and Increases Neurogenesis After Subarachnoid Hemorrhage in Mice.
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Frontiers in molecular neuroscience 2018;11:401
Frontiers in molecular neuroscience 2018;11:401
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European journal of medicinal chemistry 2018 Oct 5;158:548-558
European journal of medicinal chemistry 2018 Oct 5;158:548-558
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Guo XB, Deng X, Wei Y
Stem cells (Dayton, Ohio) 2018 Mar;36(3):406-419
Stem cells (Dayton, Ohio) 2018 Mar;36(3):406-419
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Cell reports 2018 Mar 20;22(12):3277-3291
Cell reports 2018 Mar 20;22(12):3277-3291
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Jing H, Zhou Y, Fang L, Ding Z, Wang D, Ke W, Chen H, Xiao S
Frontiers in immunology 2017;8:1365
Frontiers in immunology 2017;8:1365
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Proteomics 2017 Jul;17(13-14)
Proteomics 2017 Jul;17(13-14)
Isoform composition and gene expression of thick and thin filament proteins in striated muscles of mice after 30-day space flight.
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BioMed research international 2015;2015:104735
BioMed research international 2015;2015:104735
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HSP90 antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human HSP90. This antibody recognizes human antigen. The HSP90 antibody has been validated for the following applications: ELISA, WB analysis.
