60318-1-Ig

antibody from Proteintech Group

Targeting: HSP90AA1 FLJ31884, Hsp89, Hsp90, HSP90N, HSPC1, HSPCA

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

60318-1-Ig

Provider

Proteintech Group

Product name

HSP90 antibody

Antibody type

Monoclonal

Description

HSP90 antibody (Cat. #60318-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat, pig and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat, Porcine

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3F11C1

Vial size

20ul, 150ul

References

Submitted references

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STAU1 promotes adipogenesis by regulating the alternative splicing of Pparγ2 mRNA.

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A curcumin analogue GO-Y030 depletes cancer stem cells by inhibiting the interaction between the HSP70/HSP40 complex and its substrates.

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9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3β and HSP90β.

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QHRD106 ameliorates ischemic stroke injury as a long-acting tissue kallikrein preparation.

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Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer.

Zhang Y, Fan A, Li Y, Liu Z, Yu L, Guo J, Hou J, Li X, Chen W
Cancer letters 2023 Jul 10;566:216244

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SIRT2 promotes cell proliferation and migration through mediating ERK1/2 activation and lactosylceramide accumulation in prostate cancer.

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Inhibition of EZH2 Causes Retrotransposon Derepression and Immune Activation in Porcine Lung Alveolar Macrophages.

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Targeted Protein Degradation Induced by HEMTACs Based on HSP90.

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HOXC11 drives lung adenocarcinoma progression through transcriptional regulation of SPHK1.

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Bone Marrow Mesenchymal Stem Cell-Derived Dermcidin-Containing Migrasomes enhance LC3-Associated Phagocytosis of Pulmonary Macrophages and Protect against Post-Stroke Pneumonia.

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ATF4/MYC Regulates MTHFD2 to Promote NSCLC Progression by Mediating Redox Homeostasis.

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The potential role of exosomal miRNAs and membrane proteins in acute HIV-infected people.

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Identification of a novel pyridine derivative with inhibitory activity against ovarian cancer progression in vivo and in vitro.

Si L, Lai T, Zhao J, Jin Y, Qi M, Li M, Fu H, Shi X, Ma L, Guo R
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PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity.

Li C, Pan Y, Tan Y, Wang Y, Sun X
Frontiers in cell and developmental biology 2022;10:896014

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Insulin induces insulin receptor degradation in the liver through EphB4.

Liu X, Wang K, Hou S, Jiang Q, Ma C, Zhao Q, Kong L, Chen J, Wang Z, Zhang H, Yuan T, Li Y, Huan Y, Shen Z, Hu Z, Huang Z, Cui B, Li P
Nature metabolism 2022 Sep;4(9):1202-1213

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Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.

Boland S, Swarup S, Ambaw YA, Malia PC, Richards RC, Fischer AW, Singh S, Aggarwal G, Spina S, Nana AL, Grinberg LT, Seeley WW, Surma MA, Klose C, Paulo JA, Nguyen AD, Harper JW, Walther TC, Farese RV Jr
Nature communications 2022 Oct 7;13(1):5924

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NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma.

Zhan Y, Zhang Z, Liu Y, Fang Y, Xie Y, Zheng Y, Li G, Liang L, Ding Y
BMC medicine 2022 Oct 19;20(1):365

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Histone Methyltransferase MLL1 Mediates Oxidative Stress and Apoptosis upon Deoxynivalenol Exposure in the Intestinal Porcine Epithelial Cells.

Shi D, Shan Y, Zhu X, Wang H, Wu S, Wu Z, Bao W
Antioxidants (Basel, Switzerland) 2022 Oct 11;11(10)

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Effect and Mechanism Analysis of Pig FUT8 Gene on Resistance to Escherichia coli F18 Infection.

Wu L, Wang Y, Wu S, Wu Z, Bao W
International journal of molecular sciences 2022 Nov 25;23(23)

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Independent effects of Src kinase and podoplanin on anchorage independent cell growth and migration.

Retzbach EP, Sheehan SA, Krishnan H, Zheng H, Zhao C, Goldberg GS
Molecular carcinogenesis 2022 Jul;61(7):677-689

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Genome-wide transcriptional profiling and functional analysis reveal miR-330-MAPK15 axis involving in cellular responses to deoxynivalenol exposure.

Wang H, Zhou Y, Xu C, Cao Y, Xiao Y, Cai D, Uemoto Y, Wu S, Bao W
Chemosphere 2022 Jul;298:134199

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Adtrp regulates thermogenic activity of adipose tissue via mediating the secretion of S100b.

Li P, Song R, Du Y, Liu H, Li X
Cellular and molecular life sciences : CMLS 2022 Jul 8;79(8):407

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Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells.

Xu D, Ma R, Ju Y, Song X, Niu B, Hong W, Wang R, Yang Q, Zhao Z, Zhang Y, Zheng Y, Bai Q, Lv M, Sun N, Li X
Nature communications 2022 Jul 30;13(1):4428

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Cold Stress Induced Liver Injury of Mice through Activated NLRP3/Caspase-1/GSDMD Pyroptosis Signaling Pathway.

Liu Y, Xue N, Zhang B, Lv H, Li S
Biomolecules 2022 Jul 1;12(7)

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Plasma extracellular vesicle microRNA profiling and the identification of a diagnostic signature for stage I lung adenocarcinoma.

Gao S, Guo W, Liu T, Liang N, Ma Q, Gao Y, Tan F, Xue Q, He J
Cancer science 2022 Feb;113(2):648-659

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Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma.

Xu Z, Xu J, Sun S, Lin W, Li Y, Lu Q, Li F, Yang Z, Lu Y, Liu W
Redox biology 2022 Aug;54:102351

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Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis.

D'Amico D, Olmer M, Fouassier AM, Valdés P, Andreux PA, Rinsch C, Lotz M
Aging cell 2022 Aug;21(8):e13662

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Targeted inhibition of ubiquitin signaling reverses metabolic reprogramming and suppresses glioblastoma growth.

Delle Donne R, Iannucci R, Rinaldi L, Roberto L, Oliva MA, Senatore E, Borzacchiello D, Lignitto L, Giurato G, Rizzo F, Sellitto A, Chiuso F, Castaldo S, Scala G, Campani V, Nele V, De Rosa G, D'Ambrosio C, Garbi C, Scaloni A, Weisz A, Ambrosino C, Arcella A, Feliciello A
Communications biology 2022 Aug 2;5(1):780

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Occludin facilitates tumour angiogenesis in bladder cancer by regulating IL8/STAT3 through STAT4.

Yang F, Liu XQ, He JZ, Xian SP, Yang PF, Mai ZY, Li M, Liu Y, Zhang XD
Journal of cellular and molecular medicine 2022 Apr;26(8):2363-2376

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Plasma extracellular vesicle long RNA profiling identifies a diagnostic signature for stage I lung adenocarcinoma.

Guo W, Huai Q, Liu T, Zhang G, Liang N, Ma Q, Liu X, Tan F, Xue Q, Gao S, Gao Y, He J
Translational lung cancer research 2022 Apr;11(4):572-587

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MCMBP promotes the assembly of the MCM2-7 hetero-hexamer to ensure robust DNA replication in human cells.

Saito Y, Santosa V, Ishiguro KI, Kanemaki MT
eLife 2022 Apr 19;11

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Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.

Wang CM, Li HF, Wang XK, Li WG, Su Q, Xiao X, Hao TF, Chen W, Zhang YW, Zhang HY, Wu W, Hu ZR, Zhao GY, Huo MY, He YL, Zhang CH
International journal of biological sciences 2021;17(11):2811-2825

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The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice.

Yu Y, Liu X, Zhao Z, Xu Z, Qiao Y, Zhou Y, Qiao H, Zhong J, Dai J, Suo G
Frontiers in pharmacology 2021;12:747223

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YAP drives fate conversion and chemoresistance of small cell lung cancer.

Wu Q, Guo J, Liu Y, Zheng Q, Li X, Wu C, Fang D, Chen X, Ma L, Xu P, Xu X, Liao C, Wu M, Shen L, Song H
Science advances 2021 Oct;7(40):eabg1850

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Chromatin Accessibility and Transcriptomic Alterations in Murine Ovarian Granulosa Cells upon Deoxynivalenol Exposure.

Fan H, Ren Z, Xu C, Wang H, Wu Z, Rehman ZU, Wu S, Sun MA, Bao W
Cells 2021 Oct 20;10(11)

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Melatonin Ameliorates the Toxicity Induced by Deoxynivalenol in Murine Ovary Granulosa Cells by Antioxidative and Anti-Inflammatory Effects.

Fan H, Wang S, Wang H, Sun M, Wu S, Bao W
Antioxidants (Basel, Switzerland) 2021 Jun 29;10(7)

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Effects of temperature on proliferation of myoblasts from donor piglets with different thermoregulatory maturities.

Metzger K, Dannenberger D, Tuchscherer A, Ponsuksili S, Kalbe C
BMC molecular and cell biology 2021 Jun 26;22(1):36

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The E3 Ubiquitin Ligase RNF5 Facilitates SARS-CoV-2 Membrane Protein-Mediated Virion Release.

Yuan Z, Hu B, Xiao H, Tan X, Li Y, Tang K, Zhang Y, Cai K, Ding B
mBio 2021 Feb 22;13(1):e0316821

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(20S) Ginsenoside Rh2 Exerts Its Anti-Tumor Effect by Disrupting the HSP90A-Cdc37 System in Human Liver Cancer Cells.

Chen C, Wang YS, Zhang ET, Li GA, Liu WY, Li Y, Jin YH
International journal of molecular sciences 2021 Dec 6;22(23)

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Elevated matrix metalloproteinase-9 levels in neuronal extracellular vesicles in Alzheimer's disease.

Gu D, Liu F, Meng M, Zhang L, Gordon ML, Wang Y, Cai L, Zhang N
Annals of clinical and translational neurology 2020 Sep;7(9):1681-1691

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MSC-derived exosomes promote recovery from traumatic brain injury via microglia/macrophages in rat.

Chen Y, Li J, Ma B, Li N, Wang S, Sun Z, Xue C, Han Q, Wei J, Zhao RC
Aging 2020 Sep 23;12(18):18274-18296

---

Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation.

Xie M, Yu T, Jing X, Ma L, Fan Y, Yang F, Ma P, Jiang H, Wu X, Shu Y, Xu T
Molecular cancer 2020 Jun 29;19(1):112

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PES1 is a critical component of telomerase assembly and regulates cellular senescence.

Cheng L, Yuan B, Ying S, Niu C, Mai H, Guan X, Yang X, Teng Y, Lin J, Huang J, Jin R, Wu J, Liu B, Chang S, Wang E, Zhang C, Hou N, Cheng X, Xu D, Yang X, Gao S, Ye Q
Science advances 2019 May;5(5):eaav1090

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PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma.

Feng J, Wu L, Ji J, Chen K, Yu Q, Zhang J, Chen J, Mao Y, Wang F, Dai W, Xu L, Wu J, Guo C
Journal of experimental & clinical cancer research : CR 2019 May 17;38(1):204

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Inhibition of Heat Shock Protein 90 by 17-AAG Reduces Inflammation via P2X7 Receptor/NLRP3 Inflammasome Pathway and Increases Neurogenesis After Subarachnoid Hemorrhage in Mice.

Zuo Y, Wang J, Liao F, Yan X, Li J, Huang L, Liu F
Frontiers in molecular neuroscience 2018;11:401

---

Four new antitumor metabolites isolated from a mutant 3-f-31 strain derived from Penicillium purpurogenum G59.

Wang N, Li CW, Cui CB, Cai B, Xu LL, Zhu HJ
European journal of medicinal chemistry 2018 Oct 5;158:548-558

---

Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation.

Guo XB, Deng X, Wei Y
Stem cells (Dayton, Ohio) 2018 Mar;36(3):406-419

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The LIS1/NDE1 Complex Is Essential for FGF Signaling by Regulating FGF Receptor Intracellular Trafficking.

Liu L, Lu J, Li X, Wu A, Wu Q, Zhao M, Tang N, Song H
Cell reports 2018 Mar 20;22(12):3277-3291

---

DExD/H-Box Helicase 36 Signaling via Myeloid Differentiation Primary Response Gene 88 Contributes to NF-κB Activation to Type 2 Porcine Reproductive and Respiratory Syndrome Virus Infection.

Jing H, Zhou Y, Fang L, Ding Z, Wang D, Ke W, Chen H, Xiao S
Frontiers in immunology 2017;8:1365

---

Motile hepatocellular carcinoma cells preferentially secret sugar metabolism regulatory proteins via exosomes.

Zhang J, Lu S, Zhou Y, Meng K, Chen Z, Cui Y, Shi Y, Wang T, He QY
Proteomics 2017 Jul;17(13-14)

---

Isoform composition and gene expression of thick and thin filament proteins in striated muscles of mice after 30-day space flight.

Ulanova A, Gritsyna Y, Vikhlyantsev I, Salmov N, Bobylev A, Abdusalamova Z, Rogachevsky V, Shenkman B, Podlubnaya Z
BioMed research international 2015;2015:104735

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The HSP90 antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human HSP90. This antibody recognizes human antigen. The HSP90 antibody has been validated for the following applications: ELISA, WB analysis.

Appendix

60318-1-Ig.pdf

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