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Learn13171-1-AP
antibody from Proteintech Group
Targeting: HSP90AA1
FLJ31884, Hsp89, Hsp90, HSP90N, HSPC1, HSPCA
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [515]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 13171-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13171-1-AP, RRID:AB_2120924
- Product name
- HSP90 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HSP90 antibody (Cat. #13171-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Bioactive derivatives of the antimicrobial peptide esculentin-1a promote human dermal fibroblast migration and activate genes involved in early wound healing.
Macrophage SH3 domain‑containing GRB2‑like protein B1 is required for Rab7‑mediated mitophagy in inflammation during sea water drowning acute lung injury.
PIAS4 inhibition induces cell cycle arrest and exhibits a synergistic effect in combination with CDK4/6 inhibitor in breast cancer treatment.
Stem Cell-Derived Exosomes Improve Neurological Dysfunction in a Rat Model of Moderate-to-Severe Cerebral Palsy.
Minimolide F alleviates inflammatory diseases by specifically targeting STING and blocking IRF3 recruitment.
Gut Microbiota-Derived Tryptophan Indole Metabolites Ameliorate Collagen-Induced Arthritis in Mice Via Aryl Hydrocarbon Receptor Activation.
Amygdalin synergizes with the TNF-α monoclonal antibody infliximab to modulate HSP90 and related necro-inflammatory/oxidative stress pathways in a rat model of hepatic I/R.
Decreased Glucose Metabolism and Declined Chaperones Are Unique Features Required for the Survival of Senescent Fibroblasts and Pyruvate Dehydrogenase Is a Potent Senolytic Target.
Vitamin A and its analogues modulate MUFAs metabolism to improve ferroptosis and aging by direct targeting of ACSL3.
Ribonuclease κ promotes longevity by preventing age-associated accumulation of circular RNA in stress granules.
GLUD1 supports ovarian cancer progression by counteracting anoikis via ARAF/MEK/ERK signaling.
Multi-omics and network pharmacology reveal the mechanisms of Scutellaria barbata D.Don and Scleromitrion diffusum (Willd.) R.J.Wang against pancreatic cancer.
Cars2-Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2.
Integrative computational and experimental analysis identifies MEK-mediated carcinogenic effects of bisphenol A and diethyl phthalate in head and neck cancer.
PARKIN overexpression confers cardioprotection via suppressing the mtDNA-cGAS-STING axis in myocardial ischemia/reperfusion injury.
Ailanthone ameliorates CCl(4)-induced liver fibrosis by targeting PKM2-mediated macrophage M1 polarization and glycolytic reprogramming.
Mn(3)O(4)-potentiated bifunctional hydrogel for mild temperature-controlled tumor ablation and osteogenesis.
A unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy.
Oroxin A suppresses non-small cell lung cancer via the HSP90AA1/AKT signaling pathway.
Microenvironment-activatable nanoagent for real-time NIR-II monitoring and targeted therapy of arterial restenosis.
Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice.
Tumor-Derived CDC37 Inhibits Antigen Cross-Presentation in Dendritic Cells and Impairs Anti-Tumor Immunity in Breast Cancer.
The Circadian Transcription Factor CLOCK Modulates Oxidative Stress Resistance via the ACHL-Relish Axis in Drosophila.
Fractional carbon dioxide laser-induced photothermal activation of mesenchymal stem cell-derived exosomes accelerates diabetic wound healing by enhancing angiogenesis.
C-C motif receptor 2 is a core profibrotic factor in uremic cardiomyopathy.
Integrated spatial and single-cell transcriptomics reveals RPL8 as a prognostic biomarker and therapeutic target in hepatocellular carcinoma.
Autocrine Netrin-1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet-Induced Metabolic Dysfunction-Associated Steatohepatitis in Mice.
Epithelial Dynamics of Cystogenesis in Genetic Models of Autosomal Dominant Polycystic Kidney Disease.
Investigating the mechanisms by which bisphenol A affects osteoarthritis through a novel network toxicology framework and experimental validation.
Role of lipid rafts in the FGFR2c-mediated oncogenic signaling by involvement of TRPA1 channel in pancreatic ductal adenocarcinoma cells.
PRMT3-mediated post-translational adaptation to fasting regulates metabolic flexibility.
Antigen-encoding circular single-stranded DNA for cancer vaccine.
VDAC1 protein derived from extracellular vesicles promotes paclitaxel resistance in gastric cancer through autophagy and mitophagy.
Maternal Fine Particulate Matter Exposure Impairs Inguinal White Adipose Tissue Plasticity in Middle-Aged Male Mouse Offspring.
Ginkgetin inhibits non-small cell lung cancer via the HSP90-AKT signaling pathway.
Cytosine base editor-mediated ZSCAN4 ablation impairs zygotic genome activation via epigenetic dysregulation in porcine parthenogenetic embryos.
Recoding multiple rare codons enables the simultaneous incorporation of up to five distinct noncanonical amino acids.
Ferritin-Doped Nanoparticles Triggered Tumor-Specific Darkening for Enhanced Photothermal Tumor Ablation and Immune Activation.
Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis.
Neuroprotective effects of quercetin in LPS-induced depression: implications for antidepressant therapy.
GPX4 predicts poor prognosis and regulates tumor proliferation and senescence in colorectal adenocarcinoma.
Ultrasound-Targeted Nanobubbles Codelivering NKP-1339 and miR-142-5p for Synergistic Mitochondrial Immunogenic Cell Death and PD-L1 Inhibition in Cancer Therapy.
Heat shock protein 90 mediates the protective effects of vericiguat on myocardial ischemia/reperfusion injury by inhibiting toll-like receptor 4 and c-Jun N-terminal kinases.
SESN2 inhibits tubular exosome secretion and diabetic kidney disease progression by restoring the autophagy‒lysosome pathway.
GDF10 attenuates MASH progression by restoring quiescent hepatic stellate cells via competitive inhibition of TGF-β/SMAD2 signaling.
Unveiling the Novel Anti - Tumor Potential of Digitonin, a Steroidal Saponin, in Gastric Cancer: A Network Pharmacology and Experimental Validation Study.
Barnesiella intestinihominis improves gut microbiota disruption and intestinal barrier integrity in mice with impaired glucose regulation.
Fbxo16 mediates degradation of NF-κB p65 subunit and inhibits inflammatory response in dendritic cells.
Reversed role of CD36 deficiency in high-fat diet or methionine/choline-deficient diet-induced hepatic steatosis and steatohepatitis.
ASPHD1 Is a tumor-suppressive and prognostic marker in glioma.
Isowighteone attenuates vascular calcification by targeting HSP90AA1-mediated PI3K-Akt pathway and suppressing osteogenic gene expression.
Ginsenoside Rg5 enhances Abemaciclib sensitivity in ER+ breast cancer by modulating cell cycle proteins via transcriptional and post-translational levels.
Hepatic ASPG-mediated lysophosphatidylinositol catabolism impairs insulin signal transduction.
Roles of human SPATA3 in cell proliferation and expression pattern of Spata3 in mouse testis.
METTL3 Silencing Suppresses Cardiac Fibrosis Post Myocardial Infarction via m6A Modification of SMOC2.
Photodynamic enhancement of PROTAC prodrug activation in hypoxic tumors.
Dihydrotanshinone I, a main compound of Salvia miltiorrhiza, alleviates autoimmune and inflammatory diseases by directly targeting IRF3.
Epoxide hydrolases are involved in the metabolism of 5(6)-epoxyeicosatrienoic acid.
Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps.
A Preliminary Study of the Relationship Between Zinc and the AhR Signaling Pathway During Palatal Development.
Hepatocyte FAM210A deficiency disrupts mitochondrial function and triggers juvenile steatosis with compensatory repair in adulthood.
Clinical, neuropathological, and biochemical characterization of ALS in a large CHCHD10 R15L family.
SHP2 genetic variants in NSML-associated RASopathies disrupt the PZR-IRX transcription factor signaling axis.
LncRNA AC021683.2 promotes chemotherapy resistance in acute myeloid leukemia.
Magnesium ions attenuate tendon graft fibrosis during its ligamentization after ACL reconstruction through modulation of fibroblast to myofibroblast trans-differentiation by promoting PGE2 secretion.
Dual-Functional Silicon-Based Nanofluorescent Platform for Iron Detection and Capecitabine Delivery in Colorectal Cancer Treatment.
Streptococcus pyogenes EVs induce the alternative inflammasome via caspase-4/-5 in human monocytes.
Guanosine enhances thermogenesis and impairs KEAP1-mediated NRF2 degradation to resist ferroptosis in brown adipose tissue.
Salvia miltiorrhiza water extract ameliorated cGAS-STING-mediated acute liver injury by blocking interaction between STING and TBK1.
HSP90 Mediates Targeted Degradation of Nonclient Protein PARP1 for Breast Cancer Treatment.
IRE1α translational suppression potentiates STING-dependent chemoresistance in pancreatic cancer.
Gold-Decorated Upconversion Luminescent Nanozyme Enables ROS-Responsive Antioxidant for Myocardial Injury Repair.
Exploring the mechanism of volatile organic compounds in respiratory tract tumors based on network toxicology and molecular simulation.
Novel E-F ring derivatives of aconitine scaffold as potent Hsp90 inhibitors for the treatment of colorectal cancer.
Small Extracellular Vesicles Derived from NF2-Associated Schwannoma Cells Modulate Tumor Progression and Immunity via HSP90.
A Phototherapy Nanosensitizer-Unlocked Multihit Strategy to Inhibit Tumor Stemness and Potentiate Sorafenib Response in Hepatocellular Carcinoma.
The deubiquitinase USP17LA negatively regulates T-cell activation and attenuates anti-tumor immunity.
Bald disease in a natural population of the purple sea urchin Paracentrotus lividus of the Mediterranean Sea: From spines to tissues.
Andrographolide Promotes Ferroptosis in Pancreatic Cancer via Targeting and Activating HSP90/GPX4 Ubiquitination.
Gallic acid lessens kidney injury induced by inorganic arsenic and zinc oxide nanoparticles in rats via controlling electrolyte balance, oxidative stress, and Nrf-2 and HSP-90 expression.
Enhancer regulator MLL4 controls skeletal muscle metabolic efficiency by limiting AMPK-mediated fuel catabolism.
Quercetin ameliorates doxorubicin-induced atrial fibrillation via EGFR-mediated restoration of autophagic flux.
Quercetin as a Novel Antidepressant: Mechanistic Insights into Its Neuroprotective and Anti-inflammatory Effects.
The novel selective HDAC1 inhibitor ZJH-1 exhibits potent antitumor activity in castration-resistant prostate cancer, potentially involving HSP90AA1.
Brigatinib activates inflammasomes: Implication for immune-related adverse events.
DNMT3B inhibits PCV2 replication via targeting TMEM37 to regulate Ca(2 +) influx in PK15 cells.
Genetic mutation in HSF4 is associated with retinal degeneration in mice.
Methionine is an essential amino acid in doxorubicin-induced cardiotoxicity through modulating mitophagy.
A cardiac fibroblast-enriched micropeptide regulates inflammation in ischemia/reperfusion injury.
Advanced Paternal Age and Sperm Proteome Dynamics: A Possible Explanation for Age-Associated Male Fertility Decline.
hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer.
Accelerated differentiation of photothermal effect-induced mesenchymal stem cells regulated by activating HSP90-autophagy boosts wound repair.
Anemarrhena asphodeloides Bunge and Phellodendri Chinensis Cortex inhibits the PTGS2/EP2/cAMP/Epac1 signaling pathway to reduce microglial M1 polarization, thereby blocking chronic stress-induced depression-like behavior.
Tea Polyphenols Mitigate Radiation-Induced Ferroptosis and Intestinal Injury by Targeting the Nrf2/HO-1/GPX4 Signaling Pathway.
FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation.
COPB1 deficiency triggers osteoporosis with elevated iron stores by inducing osteoblast ferroptosis.
SLC13A2 promotes hepatocyte metabolic remodeling and liver regeneration by enhancing de novo cholesterol biosynthesis.
Bisdemethoxycurcumin mitigates traumatic brain injury in rats by modulating autophagy and oxidative stress via heat shock protein 90 alpha family class A member 1-mediated nuclear translocation of transcription factor EB.
Interleukin-37 promotes wound healing in diabetic mice by inhibiting the MAPK/NLRP3 pathway.
Excessive MYC Orchestrates Macrophages induced Chromatin Remodeling to Sustain Micropapillary-Patterned Malignancy in Lung Adenocarcinoma.
Inhibiting HMGB1/AGER/NF-κB pathway prevents pro-inflammatory microglia polarization and protect photoreceptors in retinitis pigmentosa.
FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology.
Endophilin B1 is essential for maintaining cardiac function by regulating mitocytosis.
Phenethyl isothiocyanate ameliorates liver injuries secondary to inflammatory bowel disease.
Targeting USP8 causes synthetic lethality through degradation of FGFR2 in ARID1A-deficient ovarian clear cell carcinoma.
Microenvironment-induced programmable nanotherapeutics restore mitochondrial dysfunction for the amelioration of non-alcoholic fatty liver disease.
Angiotensin 1-7 Attenuates the Development of Ischemia-Reperfusion-Induced Arrhythmia in Rats: Electrophysiology, Molecular, and Immunohistochemical Study.
Meg3-NONO-RAR axis mediates RA pathway activation in TCDD-induced cleft palate.
Endoscopic nasal delivery of engineered endothelial progenitor cell-derived exosomes improves angiogenesis and neurological deficits in rats with intracerebral hemorrhage.
Black phosphorus nanosheets activate tumor immunity of glioblastoma by modulating the expression of the immunosuppressive molecule PD-L1.
α‑ketoglutarate protects against septic cardiomyopathy by improving mitochondrial mitophagy and fission.
Taurine Alleviates Pancreatic β-Cell Senescence by Inhibition of p53 Pathway.
GART promotes multiple myeloma malignancy via tumor stemness mediated by activating the HSP90α/CDK6/β-catenin axis.
Erzhi pill promotes norepinephrine synthesis in locus coeruleus through ERβ-TFAP2A-TH plays a neuroprotective role.
Extrusion fountains are restricted by WAPL-dependent cohesin release and CTCF barriers.
An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis.
Oxaliplatin accelerates immunogenic cell death by activating the cGAS/STING/TBK1/IRF5 pathway in gastric cancer.
Sex-dependent effects of heat exposure on the middle ear health in mice.
Intermediate Filament Protein BFSP1 Maintains Oocyte Asymmetric Division by Modulating Spindle Length.
Xanthosine alleviates myocardial ischemia-reperfusion injury through attenuation of cardiomyocyte ferroptosis.
Heat shock protein 90 chaperone activity is required for hepatitis A virus replication.
Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis.
Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction.
Gambogic acid and IR780 self-assembled nanoparticles for combined chemo-phototherapy.
Quercetin inhibits hydrogen peroxide-induced cleavage of heat shock protein 90 to prevent glutathione peroxidase 4 degradation via chaperone-mediated autophagy.
C9ORF72 poly-PR induces TDP-43 nuclear condensation via NEAT1 and is modulated by HSP70 activity.
Deciphering the Transcriptional Metabolic Profile of Adipose-Derived Stem Cells During Osteogenic Differentiation and Epigenetic Drug Treatment.
More than just DNA damage: Pt(ΙΙ)-NHC complexes derived from 4,5-diarylimidazoles augment immunogenic cell death.
Heterogeneous nuclear ribonucleoprotein C promotes non-small cell lung cancer progression by enhancing XB130 mRNA stability and translation.
Shuangdan Jiedu Decoction improved LPS-induced acute lung injury by regulating both cGAS-STING pathway and inflammasome.
AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice.
RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus.
Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway.
Structural Plasticity of RRE Stem-Loop II Modulates Nuclear Export of HIV-1 RNA.
Novel reporter of the PINK1-Parkin mitophagy pathway identifies its damage sensor in the import gate.
Paeoniflorin Inhibits Porcine Circovirus Type 2 Replication by Inhibiting Autophagy and Targeting AKT/mTOR Signaling.
Exosomes containing miR-148a-3p derived from mesenchymal stem cells suppress epithelial-mesenchymal transition in lens epithelial cells.
HSP90 co-regulates the formation and nuclear distribution of the glycolytic output complex to promote resistance and poor prognosis in gastric cancer patients.
Non-catalytic mechanisms of KMT5C regulating hepatic gluconeogenesis.
Cadmium exposure induces oxidative stress-mediated necroptosis via TLR4/NF-κB signaling pathway in pig epididymis.
The receptor tyrosine kinase ErbB2/HER2 governs CDK4 inhibitor sensitivity, timing, and irreversibility of the G1/S transition.
The suprachiasmatic nucleus regulates brown fat thermogenesis in male mice through an adrenergic receptor ADRB3-S100B signaling pathway.
Extracellular vesicles from obese visceral adipose promote pancreatic cancer development and resistance to immune checkpoint blockade therapy.
Ubiquitination by HRD1 is essential for TLR3 trafficking and its innate immune signaling.
Heparanase 1 produced by keratinocytes contributes to psoriatic inflammation by promoting neutrophil infiltration.
Extracellular vesicle-mediated delivery of circp53 suppresses the progression of multiple cancers by activating the CypD/TRAP/HSP90 pathway.
Kurarinone Alleviates cGAS-STING-Triggered Inflammatory Diseases by Targeting STING.
Immunogenic cuproptosis in cancer immunotherapy via an in situ cuproptosis-inducing system.
Combining label-free quantitative proteomics and 2D-DIGE to identify the potential targets of Sini Decoction acting on myocardial infarction.
Cadmium Exposure Induces Inflammation Through Oxidative Stress-Mediated Activation of the NF-κB Signaling Pathway and Causes Heat Shock Response in a Piglet Testis.
HnRNPR promotes non-small cell lung cancer progression by protecting XB130 mRNA from XRN1- and DIS3L2-mediated degradation.
SD49-7 attenuates cardiac hypertrophy by upregulation of S100B through KDM4A inhibition.
Nanoparticle conjugation of ginsenoside Rh2 enhanced antitumor efficacy on hepatocellular carcinoma.
Cardiopulmonary Bypass-Induced IL-17A Aggravates Caspase-12-Dependent Neuronal Apoptosis Through the Act1-IRE1-JNK1 Pathway.
GLUTs-Facilitated Targeting BRD4 Degradation in Breast Cancer through Carbohydrate-Conjugated PROTACs.
Biomineralized Albumin-Macrocyclic Conjugates for Synergistic Metal Ion-Based Combination Therapy in Cancer Treatment.
Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation.
Browning effect of LncRNA00602 in Ad36-induced differentiated adipocytes.
Integration of Metabolomics, Transcriptomics, and 16s rRNA Sequencing Reveals the Mechanism of Morus alba L. (Sangzhi) Alkaloids (SZ-A) in Improving Cholesterol Metabolism in Diabetic Rats.
Exploring the anti-NSCLC mechanism of phillyrin targeting inhibition of the HSP90-AKT pathway.
HSP90 Complex From OLP Lesion Induces T-Cell Polarization via Activation of Dendritic Cells.
Hepatoprotective effects of polysaccharide from Morchella esculenta are associated with activation of the AMPK/Sirt1 signaling pathway in mice with NAFLD.
Targeting HSP90AA1 to overcome multiple drug resistance in breast cancer using magnetic nanoparticles loaded with salicylic acid.
3-Hydroxypropionaldehyde modulates tryptophan metabolism to activate AhR signaling and alleviate ethanol-induced liver injury.
Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD.
Burn-Induced Gut Microbiota Dysbiosis Aggravates Skeletal Muscle Atrophy by Tryptophan-Kynurenine Mediated AHR Pathway Activation.
Network Pharmacology Integrated Experimental Validation Uncover Quercetin as the Key Ingredient of Hedyotis diffusa Anti-BRCA.
Liraglutide modulates ALCAT1-Mediated cardiolipin remodeling to improve cardiac function in obese mice.
Estradiol Alleviates Elevated Temperature-Induced Damage in Yak Oviductal Epithelial Cells by Maintaining Endoplasmic Reticulum Calcium Homeostasis.
An unconventional autophagic pathway that inhibits ATP secretion during apoptotic cell death.
Polyoxometalates Ameliorate Metabolic Dysfunction-Associated Steatotic Liver Disease by Activating the AMPK Signaling Pathway.
Heat acclimation with probiotics-based ORS supplementation alleviates heat stroke-induced multiple organ dysfunction via improving intestinal thermotolerance and modulating gut microbiota in rats.
A rapid and simple non-radioactive assay for measuring uptake by solute carrier transporters.
Quercetin Ameliorates Cognitive Impairment in Depression by Targeting HSP90 to Inhibit NLRP3 Inflammasome Activation.
Effect of cholesterol-loaded cyclodextrin treatment on boar sperm cryopreservation.
Zinc-Mediated Endoplasmic Reticulum Stress and Metallothionein Alleviate Arsenic-Induced Cardiotoxicity in Cyprinus Carpio.
Hsp90 Promotes Gastric Cancer Cell Metastasis and Stemness by Regulating the Regional Distribution of Glycolysis-Related Metabolic Enzymes in the Cytoplasm.
Discovery of novel quinoline scaffold selective estrogen receptor degraders (SERDs) for treatment of ER positive breast cancer with enhanced antiproliferative bioactivity through immunogenic cell death (ICD) effects.
Pentagalloylglucose alleviates acetaminophen-induced acute liver injury by modulating inflammation via cGAS-STING pathway.
DVL/GSK3/ISL1 pathway signaling: unraveling the mechanism of SIRT3 in neurogenesis and AD therapy.
Roles of m(6)A modification in regulating PPER pathway in cadmium-induced pancreatic β cell death.
Platelet membrane-coated oncolytic vaccinia virus with indocyanine green for the second near-infrared imaging guided multi-modal therapy of colorectal cancer.
Biomimetic nanocomplex based corneal neovascularization theranostics.
HSP90 Enhances Mitophagy to Improve the Resistance of Car-Diomyocytes to Heat Stress in Wenchang Chickens.
Exploring the anti-inflammatory and immune regulatory effects of Taohe Chengqi decoction in sepsis-induced lung injury.
Polo-like kinase 2 promotes microglial activation via regulation of the HSP90α/IKKβ pathway.
Paraventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits.
Legumain-deficient macrophages regulate inflammation and lipid metabolism in adipose tissues to protect against diet-induced obesity.
Atg16l2 augments Nlrc4 inflammasome activation by facilitating NAIPs-NLRC4 association.
DELE1 maintains muscle proteostasis to promote growth and survival in mitochondrial myopathy.
Mechanism of Gastrodin against neurotoxicity based on network pharmacology, molecular docking and experimental verification.
Celastrol induces DNA damage and cell death in BCR-ABL T315I-mutant CML by targeting YY1 and HMCES.
Total glucosides of paeony alleviates cGAS-STING-mediated diseases by blocking the STING-IRF3 interaction.
Downregulated SPESP1-driven fibroblast senescence decreases wound healing in aged mice.
Small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery.
Intermittent mild cold acclimation ameliorates intestinal inflammation and immune dysfunction in acute cold-stressed broilers by regulating the TLR4/MyD88/NF-κB pathway.
Identification of immunogenic cell death-related damage-related molecular patterns (DAMPs) to predict outcomes in patients with head and neck squamous cell carcinoma.
Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity.
Integrating cryo-OrbiSIMS with computational modelling and metadynamics simulations enhances RNA structure prediction at atomic resolution.
HSP90 Inhibition Attenuated Isoflurane-Induced Neurotoxicity in Mice and Human Neuroglioma Cells.
TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.
Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.
Identification of the Effects of 5-Azacytidine on Porcine Circovirus Type 2 Replication in Porcine Kidney Cells.
A technique for repeated blood and cerebrospinal fluid sampling from individual rats over time without the need for repeated anesthesia.
The combination of Schisandrin C and Luteolin synergistically attenuates hepatitis B virus infection via repressing HBV replication and promoting cGAS-STING pathway activation in macrophages.
Endoplasmic reticulum stress impedes regulated secretion by governing key exocytotic and granulogenic molecular switches.
Ponicidin-induced conformational changes of HSP90 regulates the MAPK pathway to relieve ulcerative colitis.
Reactive metabolite of trovafloxacin activates inflammasomes: Implications for trovafloxacin-induced liver injury.
Neutrophil-derived nanovesicles deliver IL-37 to mitigate renal ischemia-reperfusion injury via endothelial cell targeting.
Flavonoid extracted from Epimedium attenuate cGAS-STING-mediated diseases by targeting the formation of functional STING signalosome.
Compound Danshen Dripping Pill effectively alleviates cGAS-STING-triggered diseases by disrupting STING-TBK1 interaction.
SAHA/5-AZA Enhances Acetylation and Degradation of mutp53, Upregulates p21 and Downregulates c-Myc and BRCA-1 in Pancreatic Cancer Cells.
Deciphering ER stress-unfolded protein response relationship by visualizing unfolded proteins in the ER.
CGG repeats in the human FMR1 gene regulate mRNA localization and cellular stress in developing neurons.
MYG1 drives glycolysis and colorectal cancer development through nuclear-mitochondrial collaboration.
GITR exacerbates lysophosphatidylcholine-induced macrophage pyroptosis in sepsis via posttranslational regulation of NLRP3.
Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair.
Characterization of HSP90 expression and function following CNS injury.
FADD regulates adipose inflammation, adipogenesis, and adipocyte survival.
Targeting Liver Xor by GalNAc-siRNA Is an Effective Strategy for Hyperuricemia Therapy.
HSP90AB1 is a host factor that promotes porcine deltacoronavirus replication.
Candidate biomarkers in brown adipose tissue for post-mortem diagnosis of fatal hypothermia.
Chlorogenic acid regulates the expression of NPC1L1 and HMGCR through PXR and SREBP2 signaling pathways and their interactions with HSP90 to maintain cholesterol homeostasis.
Targeting HSP70 chaperones by rhein sensitizes liver cancer to artemisinin derivatives.
TRPA1 Contributes to FGFR2c Signaling and to Its Oncogenic Outcomes in Pancreatic Ductal Adenocarcinoma-Derived Cell Lines.
Didymin protects pancreatic beta cells by enhancing mitochondrial function in high-fat diet-induced impaired glucose tolerance.
Single-cell and transcriptomic analyses reveal the influence of diabetes on ovarian cancer.
The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8(+) T cells.
Amyloid aggregates induced by the p53-R280T mutation lead to loss of p53 function in nasopharyngeal carcinoma.
Proteolysis Targeting Chimeras (PROTACs) based on celastrol induce multiple protein degradation for triple-negative breast cancer treatment.
Self-heating mitochondrion-induced free radical blast for immunogenic cell death stimulation and HCC immunotherapy.
Genetically engineered M2-like macrophage-derived exosomes for P. gingivalis-suppressed cementum regeneration: From mechanism to therapy.
Ketone bodies promote epididymal white adipose expansion to alleviate liver steatosis in response to a ketogenic diet.
DELE1 promotes translation-associated homeostasis, growth, and survival in mitochondrial myopathy.
Protective effects of Pt-N-C single-atom nanozymes against myocardial ischemia-reperfusion injury.
Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer.
Dysregulation of Glucocorticoid Receptor Homeostasis and Glucocorticoid-Associated Genes in Umbilical Cord Endothelial Cells of Diet-Induced Obese Pregnant Sheep.
Herpes simplex virus type 1 modifies the protein composition of extracellular vesicles to promote neurite outgrowth and neuroinfection.
Ocular mucoadhesive and biodegradable spanlastics loaded cationic spongy insert for enhancing and sustaining the anti-inflammatory effect of prednisolone Na phosphate; Preparation, I-optimal optimization, and In-vivo evaluation.
Exploring the role of YBX3 in PEDV infection through the utilization of YBX3 knockout and overexpression cell lines.
The noncanonical RNA-binding protein RAN stabilizes the mRNA of intranuclear stress granule assembly factor G3BP1 in nasopharyngeal carcinoma.
TGF-β1-mediated upregulation of LMCD1 drives corneal myofibroblast differentiation and corneal fibrosis.
Acacetin alleviates rheumatoid arthritis by targeting HSP90 ATPase domain to promote COX-2 degradation.
The deubiquitinase OTUB1 inhibits gluconeogenesis by stabilizing YWHAB.
Zbtb7b defines a compensatory mechanism in MASLD-related HCC progression by suppressing H19-mediated hepatic lipid deposition.
Silk fibroin microneedles loaded with epigallocatechin gallate mitigate atrazine-induced testicular toxicity.
Cyberpharmacology uncover the mechanism of the total Rhizoma Coptidis extracts ameliorate chronic atrophic gastritis.
Functional anatomy of zinc finger antiviral protein complexes.
PPDPF promotes esophageal squamous cell carcinoma progression by blocking PCCA binding to PCCB and inhibiting methionine catabolism.
Dihydroartemisinin-driven TOM70 inhibition leads to mitochondrial destabilization to induce pyroptosis against lung cancer.
A small protein encoded by PCBP1-AS1 is identified as a key regulator of influenza virus replication via enhancing autophagy.
Epigenome-wide impact of MAT2A sustains the androgen-indifferent state and confers synthetic vulnerability in ERG fusion-positive prostate cancer.
Exploring the Effects and Potential Mechanisms of Hesperidin for the Treatment of CPT-11-Induced Diarrhea: Network Pharmacology, Molecular Docking, and Experimental Validation.
Extreme Heat Exposure Induced Acute Kidney Injury through NLRP3 Inflammasome Activation in Mice.
Total tanshinones ameliorates cGAS-STING-mediated inflammatory and autoimmune diseases by affecting STING-IRF3 binding.
Characterization of Novel PHEX Variants in X-linked Hypophosphatemic Rickets and Genotype-PHEX Activity Correlation.
Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage.
Twin defect-rich Pt ultrathin nanowire nanozymes alleviate inflammatory skin diseases by scavenging reactive oxygen species.
Identification of COQ2 as a regulator of proliferation and lipid peroxidation through genome-scale CRISPR-Cas9 screening in myeloma cells.
LDL receptor-related protein 5 selectively transports unesterified polyunsaturated fatty acids to intracellular compartments.
Terazosin attenuates abdominal aortic aneurysm formation by downregulating Peg3 expression to inhibit vascular smooth muscle cell apoptosis and senescence.
Up-regulation of HSP90α in HDM-induced asthma causes pyroptosis of airway epithelial cells by activating the cGAS-STING-ER stress pathway.
The coumarin component isofraxidin targets the G-protein-coupled receptor S1PR1 to modulate IL-17 signaling and alleviate ulcerative colitis.
IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline.
LRRK2 is involved in heat exposure-induced acute lung injury and alveolar type II epithelial cell dysfunction.
Tyrosine hydroxylase inhibits HCC progression by downregulating TGFβ/Smad signaling.
Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation.
Construction and validation of a prognostic signature based on necroptosis-related genes in hepatocellular carcinoma.
Sarcoma protein kinase inhibition alleviates liver fibrosis by promoting hepatic stellate cells ferroptosis.
DNAJC8: a prognostic marker and potential therapeutic target for hepatocellular carcinoma.
Unveiling the role of hypoxic macrophage-derived exosomes in driving colorectal cancer progression.
Activation of telomerase activity and telomere elongation of host cells by Theileria annulata infection.
Phenylalanine promotes alveolar macrophage pyroptosis via the activation of CaSR in ARDS.
Involvement of p38 MAPK in Leydig cell aging and age-related decline in testosterone.
Novel flavonoid 1,3,4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway.
LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11-dependent repression of CDKN2A.
1,8-cineole ameliorates colon injury by downregulating macrophage M1 polarization via inhibiting the HSP90-NLRP3-SGT1 complex.
Disulfiram suppresses epithelial-mesenchymal transition (EMT), migration and invasion in cervical cancer through the HSP90A/NDRG1 pathway.
Exploiting immunostimulatory mechanisms of immunogenic cell death to develop membrane-encapsulated nanoparticles as a potent tumor vaccine.
HSP90/CDC37 inactivation promotes degradation of LKB1 protein to suppress AMPK signaling in bronchial epithelial cells exposed to sulfur mustard analog, 2-chloroethyl ethyl sulfide.
USP14 Positively Modulates Head and Neck Squamous Carcinoma Tumorigenesis and Potentiates Heat Shock Pathway through HSF1 Stabilization.
Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway.
Identification of combinatorial miRNA panels derived from extracellular vesicles as biomarkers for esophageal squamous cell carcinoma.
Targeting HSP90 with picropodophyllin suppresses gastric cancer tumorigenesis by disrupting the association of HSP90 and AKT.
Targeting TNFAIP2 induces immunogenic cell death and sensitizes glioblastoma multiforme to anti-PD-1 therapy.
Smoking Induces a Decline in Semen Quality and the Activation of Stress Response Pathways in Sperm.
Phosphorylated YBX2 is stabilized to promote glycolysis in brown adipocytes.
LncRNA MALAT1 Promoted Neuronal Necroptosis in Cerebral Ischemia-reperfusion Mice by Stabilizing HSP90.
6-Methyl flavone inhibits Nogo-B expression and improves high fructose diet-induced liver injury in mice.
A Dihydroartemisinin-Loaded Nanoreactor Motivates Anti-Cancer Immunotherapy by Synergy-Induced Ferroptosis to Activate Cgas/STING for Reprogramming of Macrophage.
FNIP1 abrogation promotes functional revascularization of ischemic skeletal muscle by driving macrophage recruitment.
HSP90AB1 Is a Host Factor Required for Transmissible Gastroenteritis Virus Infection.
Lactate Conversion by Lactate Dehydrogenase B Is Involved in Beige Adipocyte Differentiation and Thermogenesis in Mice.
The HDAC inhibitor HFY-4A improves TUSC2 transcription to induce immunogenic cell death in breast cancer.
Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles.
Flavonoids derived from licorice suppress LPS-induced acute lung injury in mice by inhibiting the cGAS-STING signaling pathway.
Hsp90 is a potential risk factor for ovarian cancer prognosis: an evidence of a Chinese clinical center.
Poly (ADP-ribose) polymerases 16 triggers pathological cardiac hypertrophy via activating IRE1α-sXBP1-GATA4 pathway.
PPARγ Acetylation in Adipocytes Exacerbates BAT Whitening and Worsens Age-Associated Metabolic Dysfunction.
9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3β and HSP90β.
LncRNA446 Regulates Tight Junctions by Inhibiting the Ubiquitinated Degradation of Alix after Porcine Epidemic Diarrhea Virus Infection.
PPT1 regulation of HSP90α depalmitoylation participates in the pathogenesis of hyperandrogenism.
FGFR2c Upregulation Contributes to Cancer-Associated Fibroblast Program Activation and to Enhanced Autophagy in Actinic Keratosis-Derived Dermal Fibroblasts: A Possible Role in Precancerous Cell/Stromal Cell Crosstalk.
Dysregulation of striatal dopamine D2/D3 receptor-mediated by hypocretin induces depressive behaviors in rats.
Near-Infrared Phototheranostic Iron Pyrite Nanocrystals Simultaneously Induce Dual Cell Death Pathways via Enhanced Fenton Reactions in Triple-Negative Breast Cancer.
Preterm birth alters the feeding-induced activation of Akt signaling in the muscle of neonatal piglets.
Paeoniflorin protects against cisplatin-induced acute kidney injury through targeting Hsp90AA1-Akt protein-protein interaction.
Long noncoding RNA HITT coordinates with RGS2 to inhibit PD-L1 translation in T cell immunity.
Control of SOX2 protein stability and tumorigenic activity by E3 ligase CHIP in esophageal cancer cells.
Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis.
Nogo-B inhibition restricts ulcerative colitis via inhibiting p68/miR-155 signaling pathway.
Design, synthesis, and SAR study of novel flavone 1,2,4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease.
Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance.
PPARγ (Peroxisome Proliferator-Activated Receptor γ) Deacetylation Suppresses Aging-Associated Atherosclerosis and Hypercholesterolemia.
PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms.
Initiation of HIV-1 Gag lattice assembly is required for recognition of the viral genome packaging signal.
Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis.
Chlorin e6-induced photodynamic effect facilitates immunogenic cell death of lung cancer as a result of oxidative endoplasmic reticulum stress and DNA damage.
N(6)-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis.
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Exosomal HSP90 induced by remote ischemic preconditioning alleviates myocardial ischemia/reperfusion injury by inhibiting complement activation and inflammation.
Effects of heat shock protein 90 on complement activation in myocardial ischemia/reperfusion injury after pioglitazone preconditioning.
Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes.
The pterostilbene-dihydropyrazole derivative Ptd-1 ameliorates vascular calcification by regulating inflammation.
Phenylboronic Acid-Modified Near-Infrared Region II Excitation Donor-Acceptor-Donor Molecule for 2-Deoxy-d-Glucose Improved Starvation/Chemo/Photothermal Combination Therapy.
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production.
Metabolomics and Transcriptomics Analyses of Curcumin Alleviation of Ochratoxin A-Induced Hepatotoxicity.
Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development.
Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis.
Bioinformatics-based identification and validation of hub genes associated with aging in patients with coronary artery disease.
Photothermal-Ionic-Pharmacotherapy of Myocardial Infarction with Enhanced Angiogenesis and Antiapoptosis.
JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens Fiber Maturation in Murine Lens Development.
ZDHHC17 participates in the pathogenesis of polycystic ovary syndrome by affecting androgen conversion to estrogen in granulosa cells.
lnc-HC ameliorates steatosis by promoting miR-130b-3p biogenesis and the assembly of an RNA-induced silencing complex.
Mechanism of non-steroidal anti-androgen-induced liver injury: Reactive metabolites of flutamide and bicalutamide activate inflammasomes.
Exosomal PPARγ derived from macrophages suppresses LPS-induced peritonitis by negative regulation of CD14/TLR4 axis.
Transcription factor 21 accelerates vascular calcification in mice by activating the IL-6/STAT3 signaling pathway and the interplay between VSMCs and ECs.
Maresin-1 protects against pulmonary arterial hypertension by improving mitochondrial homeostasis through ALXR/HSP90α axis.
An injectable, activated neutrophil-derived exosome mimetics/extracellular matrix hybrid hydrogel with antibacterial activity and wound healing promotion effect for diabetic wound therapy.
Immunogenic cell death-based prognostic model for predicting the response to immunotherapy and common therapy in lung adenocarcinoma.
Effects of diazoxide on streptozotocin induced β cell damage via HSP70/HSP90/TLR4/AMPK signaling pathways.
An artificial intelligence network-guided signature for predicting outcome and immunotherapy response in lung adenocarcinoma patients based on 26 machine learning algorithms.
RNA-Seq-based transcriptomics analysis during the photodynamic therapy of primary cells in secondary hyperparathyroidism.
Dihydroartemisinin elicits immunogenic death through ferroptosis-triggered ER stress and DNA damage for lung cancer immunotherapy.
Mechanism of HSP90 Inhibitor in the Treatment of DSS-induced Colitis in Mice by Inhibiting MAPK Pathway and Synergistic Effect of Compound Sophorae Decoction.
Egr1 confers protection against acetaminophen‑induced hepatotoxicity via transcriptional upregulating of Acaa2.
Patient-Derived Pancreatic Cancer Cells Induce C2C12 Myotube Atrophy by Releasing Hsp70 and Hsp90.
Hepatic AMPK signaling dynamic activation in response to REDOX balance are sentinel biomarkers of exercise and antioxidant intervention to improve blood glucose control.
AHSA1 Promotes Proliferation and EMT by Regulating ERK/CALD1 Axis in Hepatocellular Carcinoma.
Daidzein alleviates doxorubicin-induced heart failure via the SIRT3/FOXO3a signaling pathway.
CTCF and cohesin promote focal detachment of DNA from the nuclear lamina.
Neural stem cell‑derived exosomes transfer miR‑124‑3p into cells to inhibit glioma growth by targeting FLOT2.
c-Myc Sustains Pancreatic Cancer Cell Survival and mutp53 Stability through the Mevalonate Pathway.
Analysis of RIOK2 Functions in Mediating the Toxic Effects of Deoxynivalenol in Porcine Intestinal Epithelial Cells.
Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation.
p38α in the preoptic area inhibits brown adipose tissue thermogenesis.
Defective Human SRP Induces Protein Quality Control and Triggers Stress Response.
Activation of the Chemokine Receptor CCR1 and Preferential Recruitment of Gαi Suppress RSV Replication: Implications for Developing Novel Respiratory Syncytial Virus Treatment Strategies.
Class 3 phosphoinositide 3-kinase promotes hepatic glucocorticoid receptor stability and transcriptional activity.
Zinc Alleviates Arsenic-Induced Inflammation and Apoptosis in the Head Kidney of Common Carp by Inhibiting Oxidative Stress and Endoplasmic Reticulum Stress.
Identification of metastasis-associated exoDEPs in colorectal cancer using label-free proteomics.
Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells.
In situ injectable hydrogel-loaded drugs induce anti-tumor immune responses in melanoma immunochemotherapy.
miR-15a and miR-20b sensitize hepatocellular carcinoma cells to sorafenib through repressing CDC37L1 and consequent PPIA downregulation.
ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress.
FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated mitochondrial fusion.
Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice.
Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90α, and RXRα.
The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice.
The impairment of DDR reduces XBP1s, further increasing DNA damage, and triggers autophagy via PERK/eIF2alpha in MM and IRE1alpha/JNK1/2 in PEL cells.
Dual targeted delivery of statins and nucleic acids by chitosan-based nanoparticles for enhanced antiatherosclerotic efficacy.
AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma.
Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy.
SLCO4A1-AS1 promotes colorectal tumourigenesis by regulating Cdk2/c-Myc signalling.
Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis.
HSP90 inhibitors 17-AAG and VER-82576 inhibit porcine deltacoronavirus replication in vitro.
High-dose VitC plus oncolytic adenoviruses enhance immunogenic tumor cell death and reprogram tumor immune microenvironment.
Novel Loss of Function Variant in BCKDK Causes a Treatable Developmental and Epileptic Encephalopathy.
VPA and TSA Interrupt the Interplay between mutp53 and HSP70, Leading to CHK1 and RAD51 Down-Regulation and Sensitizing Pancreatic Cancer Cells to AZD2461 PARP Inhibitor.
The two-domain architecture of LAMP2A regulates its interaction with Hsc70.
RNA sequence analysis reveals pathways and candidate genes associated with pancreatic acinar cells injury in a mouse pancreatitis model.
Inhibition of HSPA8 by rifampicin contributes to ferroptosis via enhancing autophagy.
Selective targeting of visceral adiposity by polycation nanomedicine.
A functionalized collagen-I scaffold delivers microRNA 21-loaded exosomes for spinal cord injury repair.
Acetylation of PPARγ in macrophages promotes visceral fat degeneration in obesity.
ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5-12-16L1 complex assembly and autophagy.
METTL3 preferentially enhances non-m(6)A translation of epigenetic factors and promotes tumourigenesis.
p62/SQSTM1 promotes mitophagy and activates the NRF2-mediated antioxidant and anti-inflammatory response restraining EBV-driven B lymphocyte proliferation.
Role of caspase-8 and/or -9 as biomarkers that can distinguish the potential to cause toxic- and immune related-adverse event, for the progress of acetaminophen-induced liver injury.
A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90.
Comparative analysis of ChAdOx1 nCoV-19 and Ad26.COV2.S SARS-CoV-2 vector vaccines.
NudC L279P Mutation Destabilizes Filamin A by Inhibiting the Hsp90 Chaperoning Pathway and Suppresses Cell Migration.
Plasma HSP90AA1 Predicts the Risk of Breast Cancer Onset and Distant Metastasis.
The Formation of Melanocyte Apoptotic Bodies in Vitiligo and the Relocation of Vitiligo Autoantigens under Oxidative Stress.
New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB.
Sorafenib-Induced Autophagy Promotes Glycolysis by Upregulating the p62/HDAC6/HSP90 Axis in Hepatocellular Carcinoma Cells.
SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation.
Osteosarcoma Cell-Derived Small Extracellular Vesicles Enhance Osteoclastogenesis and Bone Resorption Through Transferring MicroRNA-19a-3p.
The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum.
Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism.
Quantitative proteomic analysis of the effects of dietary deprivation of methionine and cystine on A549 xenograft and A549 xenograft-bearing mouse.
Mt-Keima detects PINK1-PRKN mitophagy in vivo with greater sensitivity than mito-QC.
Formation and persistence of polyglutamine aggregates in mistranslating cells.
Hsp90 and its co-chaperone Sti1 control TDP-43 misfolding and toxicity.
LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy.
A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin(2α)-induced corpus luteum regression.
Ubc13 Promotes K63-Linked Polyubiquitination of NLRP3 to Activate Inflammasome.
Inhibition of heat shock protein 90 alleviates cholestatic liver injury by decreasing IL-1β and IL-18 expression.
Single-cell RNA sequencing reveals that targeting HSP90 suppresses PDAC progression by restraining mitochondrial bioenergetics.
Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis.
Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice.
Procyanidin B2 Reduces Vascular Calcification through Inactivation of ERK1/2-RUNX2 Pathway.
Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells.
UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model.
Identification of exosome miRNAs in bronchial epithelial cells after PM2.5 chronic exposure.
LYSMD3: A mammalian pattern recognition receptor for chitin.
WAPL maintains a cohesin loading cycle to preserve cell-type-specific distal gene regulation.
The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer.
Cytoprotective Effects of Taurine on Heat-Induced Bovine Mammary Epithelial Cells In Vitro.
Echinatin effectively protects against NLRP3 inflammasome-driven diseases by targeting HSP90.
Hydrogen Peroxide-Induced Senescence Reduces the Wound Healing-Promoting Effects of Mesenchymal Stem Cell-Derived Exosomes Partially via miR-146a.
CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity.
MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2α-CYR61 axis.
In Vitro Study of Licorice on IL-1β-Induced Chondrocytes and In Silico Approach for Osteoarthritis.
Lactoferrin Alleviates Acute Alcoholic Liver Injury by Improving Redox-Stress Response Capacity in Female C57BL/6J Mice.
Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues.
PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.
Exosomal miR-193b-5p as a regulator of LPS-induced inflammation in dairy cow mammary epithelial cells.
Augmentation of the heat shock axis during exceptional longevity in Ames dwarf mice.
Amiodarone, Unlike Dronedarone, Activates Inflammasomes via Its Reactive Metabolites: Implications for Amiodarone Adverse Reactions.
Lamin-A interacting protein Hsp90 is required for DNA damage repair and chemoresistance of ovarian cancer cells.
Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effect.
Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction.
OSCC Exosomes Regulate miR-210-3p Targeting EFNA3 to Promote Oral Cancer Angiogenesis through the PI3K/AKT Pathway.
17-Allylamino-Demethoxygeldanamycin Ameliorate Microthrombosis Via HSP90/RIP3/NLRP3 Pathway After Subarachnoid Hemorrhage in Rats.
Influenza A Virus Induces Autophagy by Its Hemagglutinin Binding to Cell Surface Heat Shock Protein 90AA1.
The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer.
Hsp90 inhibitor HSP990 in very low dose upregulates EAAT2 and exerts potent antiepileptic activity.
Multifactorial Attenuation of the Murine Heat Shock Response With Age.
Heat shock protein 90 inhibitors suppress pyroptosis in THP-1 cells.
Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer.
Inhibitory effect of edible natural compounds with di- and tri-carboxyl moiety on endogenous protease inducing disassembly and degradation of myofibrils from grass carp (Ctenopharyngodon idella).
CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury.
Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity.
Light-activated oxygen self-supplied starving therapy in near-infrared (NIR) window and adjuvant hyperthermia-induced tumor ablation with an augmented sensitivity.
LongShengZhi capsule inhibits doxorubicin-induced heart failure by anti-oxidative stress.
Cytotoxic necrotizing factor 1 promotes bladder cancer angiogenesis through activating RhoC.
The Activation of Heat-Shock Protein After Copper(II) and/or Arsenic(III)-Induced Imbalance of Homeostasis, Inflammatory Response in Chicken Rectum.
Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.
Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia.
FBXL6 governs c-MYC to promote hepatocellular carcinoma through ubiquitination and stabilization of HSP90AA1.
SIRT2 suppresses expression of inflammatory factors via Hsp90-glucocorticoid receptor signalling.
NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.
Aspirin Enhances the Protection of Hsp90 from Heat-Stressed Injury in Cardiac Microvascular Endothelial Cells Through PI3K-Akt and PKM2 Pathways.
Hsp90 Relieves Heat Stress-Induced Damage in Mouse Kidneys: Involvement of Antiapoptotic PKM2-AKT and Autophagic HIF-1α Signaling.
Zinc application alleviates the adverse renal effects of arsenic stress in a protein quality control way in common carp.
Dual-specificity phosphatase 29 is induced during neurogenic skeletal muscle atrophy and attenuates glucocorticoid receptor activity in muscle cell culture.
Carnosol inhibits inflammasome activation by directly targeting HSP90 to treat inflammasome-mediated diseases.
The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions.
The LIV-1-GRPEL1 axis adjusts cell fate during anti-mitotic agent-damaged mitosis.
First Insights on the Presence of the Unfolded Protein Response in Human Spermatozoa.
Hydroxysteroid sulfotransferase 2B1 affects gastric epithelial function and carcinogenesis induced by a carcinogenic agent.
A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network.
Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system.
Identification and validation of circulating exosomes-based liquid biopsy for esophageal cancer.
Atlastin-mediated membrane tethering is critical for cargo mobility and exit from the endoplasmic reticulum.
Calpain2 but not calpain1 mediated by calpastatin following glutamate-induced regulated necrosis in rat retinal neurons.
Chaperone-mediated autophagy is involved in the execution of ferroptosis.
Cross-Species Suppression of Hepatoma Cell Growth and Migration by a Schistosoma japonicum MicroRNA.
Vesicular Stomatitis Virus Transcription Is Inhibited by TRIM69 in the Interferon-Induced Antiviral State.
KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly.
SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism.
Porcine Reproductive and Respiratory Syndrome Virus nsp11 Antagonizes Type I Interferon Signaling by Targeting IRF9.
The PERK-EIF2α-ATF4 signaling branch regulates osteoblast differentiation and proliferation by PTH.
Visualizing tRNA-dependent mistranslation in human cells.
KDM5B demethylates H3K4 to recruit XRCC1 and promote chemoresistance.
Inhibition of Heat Shock Protein 90 by 17-AAG Reduces Inflammation via P2X7 Receptor/NLRP3 Inflammasome Pathway and Increases Neurogenesis After Subarachnoid Hemorrhage in Mice.
Whole-brain low-intensity pulsed ultrasound therapy markedly improves cognitive dysfunctions in mouse models of dementia - Crucial roles of endothelial nitric oxide synthase.
Nogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells.
Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway.
Impacts of simultaneous exposure to arsenic (III) and copper (II) on inflammatory response, immune homeostasis, and heat shock response in chicken thymus.
Non-canonical roles of PFKFB3 in regulation of cell cycle through binding to CDK4.
Arsenic and/or copper caused inflammatory response via activation of inducible nitric oxide synthase pathway and triggered heat shock protein responses in testis tissues of chicken.
Intestinal Epithelial Cell-Derived LKB1 Suppresses Colitogenic Microbiota.
Inhibition of HSP90α protects cultured neurons from oxygen-glucose deprivation induced necroptosis by decreasing RIP3 expression.
HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma.
A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C. elegans.
Nogo-B receptor increases the resistance of estrogen receptor positive breast cancer to paclitaxel.
HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway.
Assessment of arsenic trioxide toxicity on cock muscular tissue: alterations of oxidative damage parameters, inflammatory cytokines and heat shock proteins.
Jolkinolide B induces apoptosis of colorectal carcinoma through ROS-ER stress-Ca(2+)-mitochondria dependent pathway.
LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection.
Proteomics and metabolomics analysis of hepatic mitochondrial metabolism in alcohol-preferring and non-preferring rats.
Copper or/and arsenic induce oxidative stress-cascaded, nuclear factor kappa B-dependent inflammation and immune imbalance, trigging heat shock response in the kidney of chicken.
Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis.
Identification of two p53 isoforms from Litopenaeus vannamei and their interaction with NF-κB to induce distinct immune response.
Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins.
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
Synergistic inhibition of tumor growth by combination treatment with drugs against different subpopulations of glioblastoma cells.
Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells.
SILAC-based quantitative proteomic analysis of secretome of Marc-145 cells infected with porcine reproductive and respiratory syndrome virus.
Cytoskeleton-centric protein transportation by exosomes transforms tumor-favorable macrophages.
Geldanamycin, an inhibitor of Hsp90, increases paclitaxel-mediated toxicity in ovarian cancer cells through sustained activation of the p38/H2AX axis.
Exogenous Estradiol Benzoate Induces Spermatogenesis Disorder through Influencing Apoptosis and Oestrogen Receptor Signalling Pathway.
Bioinformatics analysis of proteomics profiles in senescent human primary proximal tubule epithelial cells.
Changes in gene expression and content of Hsp70 and Hsp90 in striated muscles of mice after 30-day space flight on the biosatellite Bion-M1.
Tom70 mediates Sendai virus-induced apoptosis on mitochondria.
A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis.
Dynamic expression patterns of differential proteins during early invasion of hepatocellular carcinoma.
Identification of Hsf1 as a novel androgen receptor-regulated gene in mouse Sertoli cells.
PP2A-AMPKα-HSF1 axis regulates the metal-inducible expression of HSPs and ROS clearance.
Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.
Salivary monitoring related to major surgery.
Cappiello F, Grisard E, Traversa A, Ranieri D, Mangoni ML
BBA advances 2026;9:100186
BBA advances 2026;9:100186
Macrophage SH3 domain‑containing GRB2‑like protein B1 is required for Rab7‑mediated mitophagy in inflammation during sea water drowning acute lung injury.
Ning H, Deng J, Gao Y, Zhang W, Chen J, Guo X, Jin F
International journal of molecular medicine 2026 May;57(5)
International journal of molecular medicine 2026 May;57(5)
PIAS4 inhibition induces cell cycle arrest and exhibits a synergistic effect in combination with CDK4/6 inhibitor in breast cancer treatment.
Chen H, Hu X, Feng L, Cheng X, Zhu L, Xu F, Zhu T, Gao Y, Wang J, Jin H, Jiang Z
Oncogene 2026 May;45(19):1756-1770
Oncogene 2026 May;45(19):1756-1770
Stem Cell-Derived Exosomes Improve Neurological Dysfunction in a Rat Model of Moderate-to-Severe Cerebral Palsy.
Peng T Jr, Lin H, Zeng X, Xie Y, Luo J, Zhang L, Huang S, Ye Z, Guo X, Le W, Zhang M, Li W, Peng T Sr, Liu L, Han M, Gao T, Tang H, Zhang J, He L, Xu K
Stem cell reviews and reports 2026 May;22(4):1865-1885
Stem cell reviews and reports 2026 May;22(4):1865-1885
Minimolide F alleviates inflammatory diseases by specifically targeting STING and blocking IRF3 recruitment.
Wen J, Xu Y, Qin S, Guo Y, Wang X, Liu L, Lu Z, Yan Y, Zhan X, Zhao J, Xiao X, Bai Z
International immunopharmacology 2026 May 1;176:116468
International immunopharmacology 2026 May 1;176:116468
Gut Microbiota-Derived Tryptophan Indole Metabolites Ameliorate Collagen-Induced Arthritis in Mice Via Aryl Hydrocarbon Receptor Activation.
Wu L, Zhang Q, Tang Z, Li Y, Wu T, Chen L, Tan C, Zhang L, Ji X, Zhang S, Wu Y, Bozec A, Zaiss MM, Luo Y
Arthritis & rheumatology (Hoboken, N.J.) 2026 Mar;78(3):613-629
Arthritis & rheumatology (Hoboken, N.J.) 2026 Mar;78(3):613-629
Amygdalin synergizes with the TNF-α monoclonal antibody infliximab to modulate HSP90 and related necro-inflammatory/oxidative stress pathways in a rat model of hepatic I/R.
Mohamed RA, Ghoneim ME, Tawfiq RA, El Sayed NF
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar;399(5):7643-7657
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar;399(5):7643-7657
Decreased Glucose Metabolism and Declined Chaperones Are Unique Features Required for the Survival of Senescent Fibroblasts and Pyruvate Dehydrogenase Is a Potent Senolytic Target.
Zhang M, Hu Z, Piao S, Song Y, Jia Y, Liu J, Zhao N, Liu A, Fu S, Sun W, Xu H, Yang Y, Gygi SP, Zhou C
Aging cell 2026 Mar;25(3):e70434
Aging cell 2026 Mar;25(3):e70434
Vitamin A and its analogues modulate MUFAs metabolism to improve ferroptosis and aging by direct targeting of ACSL3.
Luo N, Xiao Y, Zhai Y, Li J, Lv L, Yin H, Lin F, Wan B, Zhang K, Hu J, Liu J, Dang Y, He Y, Zhao Y, Zhang Z, Nie S, Yuan HX
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1510-1529
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1510-1529
Ribonuclease κ promotes longevity by preventing age-associated accumulation of circular RNA in stress granules.
Kim SS, Ham S, Boo SH, Lee D, Min H, Kang E, Haque R, Lee H, Jung Y, Kwon S, Park S, Park HH, Kim EJE, Hwang W, Kim E, Lee GY, Park KY, Suh JM, Lee G, Kim YK, Lee SV
Molecular cell 2026 Mar 5;86(5):885-900.e14
Molecular cell 2026 Mar 5;86(5):885-900.e14
GLUD1 supports ovarian cancer progression by counteracting anoikis via ARAF/MEK/ERK signaling.
Feng H, Chen Y, Wu G, Zhang Z, Lai H, Yang C, Zhang S, Lin Y, Liu Y, Ye H, Wu S, Cao L
NPJ precision oncology 2026 Mar 5;10(1)
NPJ precision oncology 2026 Mar 5;10(1)
Multi-omics and network pharmacology reveal the mechanisms of Scutellaria barbata D.Don and Scleromitrion diffusum (Willd.) R.J.Wang against pancreatic cancer.
Zhao Z, Yang Y, Zhang L, He X, Ding K, Chen Y, Huo Y, Li P, Li R, Ali T, Zhao D, Choe H, Ma J, Shang D, Zhang L
Scientific reports 2026 Mar 27;16(1)
Scientific reports 2026 Mar 27;16(1)
Cars2-Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2.
Peng X, Song H, Long Y, Wu K, Fu Y, Zhou W, Li W, Shi Z, Zhao XY
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 18;:e22690
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 18;:e22690
Integrative computational and experimental analysis identifies MEK-mediated carcinogenic effects of bisphenol A and diethyl phthalate in head and neck cancer.
Ding R, Quan T, Wu J, Huang R, Liang L, Quan Q, Long Z
Ecotoxicology and environmental safety 2026 Mar 1;312:119924
Ecotoxicology and environmental safety 2026 Mar 1;312:119924
PARKIN overexpression confers cardioprotection via suppressing the mtDNA-cGAS-STING axis in myocardial ischemia/reperfusion injury.
Li Y, Wang Y, Zhang H, Xu P, Yuan X, Yuan H, Yang C, Zhou Y, Shen J, Du H, Gao Z, Zang J, Liang S, Qu J, Song M
Basic research in cardiology 2026 Jun;121(3):395-412
Basic research in cardiology 2026 Jun;121(3):395-412
Ailanthone ameliorates CCl(4)-induced liver fibrosis by targeting PKM2-mediated macrophage M1 polarization and glycolytic reprogramming.
Wan Y, Wang T, Wang K, Huo Q, Cheng X
International immunopharmacology 2026 Jun 15;179:116640
International immunopharmacology 2026 Jun 15;179:116640
Mn(3)O(4)-potentiated bifunctional hydrogel for mild temperature-controlled tumor ablation and osteogenesis.
Zhao Y, Wang W, Liu M, Cai Y, Wang Y, Dong Y, Bai YK, Zhu J, Tay FR, Niu L
Bioactive materials 2026 Jan;55:391-409
Bioactive materials 2026 Jan;55:391-409
A unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy.
Thayer JA, Petersen JD, Huang X, Gruel Budet LM, Hawrot J, Ramos DM, Sekine S, Li Y, Ward ME, Narendra DP
The EMBO journal 2026 Jan;45(1):64-105
The EMBO journal 2026 Jan;45(1):64-105
Oroxin A suppresses non-small cell lung cancer via the HSP90AA1/AKT signaling pathway.
Wang M, Zhang Y, Liu R, Lin J, Wang T, Dong H, Yang J, Li X, Yu D
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(2):2291-2305
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(2):2291-2305
Microenvironment-activatable nanoagent for real-time NIR-II monitoring and targeted therapy of arterial restenosis.
Meng X, Song J, Meng H, Liao C, Yin Z, Gong K, Kong D, Qi J, Duan Y
Biomaterials 2026 Jan;324:123482
Biomaterials 2026 Jan;324:123482
Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice.
Shi M, Ye Y, Hu L, Yan Y, Jiang S, Wang P, Li F, Ai M, Huang J, Yang L, Huang K, Liang M
EMBO molecular medicine 2026 Jan;18(1):55-90
EMBO molecular medicine 2026 Jan;18(1):55-90
Tumor-Derived CDC37 Inhibits Antigen Cross-Presentation in Dendritic Cells and Impairs Anti-Tumor Immunity in Breast Cancer.
Wang R, Zhang Y, Meng X, Zhao J, Xing Y, Ouyang Q, Zhang N, Chen H, Miao N, Song E, Huang D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e06518
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e06518
The Circadian Transcription Factor CLOCK Modulates Oxidative Stress Resistance via the ACHL-Relish Axis in Drosophila.
Liu X, Fang J, Cheng D, Luan W, Lv Y, Hu W, Pan L, Zhang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(4):e14388
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(4):e14388
Fractional carbon dioxide laser-induced photothermal activation of mesenchymal stem cell-derived exosomes accelerates diabetic wound healing by enhancing angiogenesis.
Chen JY, Ji Z, Guo K, Wang HN, Zhu CC, Li T, Zhao XB, Wang YT, Li Q, Jin PS, Li XY
World journal of diabetes 2026 Jan 15;17(1):112942
World journal of diabetes 2026 Jan 15;17(1):112942
C-C motif receptor 2 is a core profibrotic factor in uremic cardiomyopathy.
Bao JF, Guo BC, Mo JJ, Zhu H, Jia N, Hou F, Liu Y, Li A
Disease models & mechanisms 2026 Jan 1;19(1)
Disease models & mechanisms 2026 Jan 1;19(1)
Integrated spatial and single-cell transcriptomics reveals RPL8 as a prognostic biomarker and therapeutic target in hepatocellular carcinoma.
Tan J, Liang J, Li Y, He J, Yin H, Wu H, Luo Y, Li M, Long F, Lin H
Translational oncology 2026 Feb;64:102663
Translational oncology 2026 Feb;64:102663
Autocrine Netrin-1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet-Induced Metabolic Dysfunction-Associated Steatohepatitis in Mice.
Zhao J, Peng Y, Lei H, Wang T, Wang H, Wang B, Li J, Li X, Xiong X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e14545
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e14545
Epithelial Dynamics of Cystogenesis in Genetic Models of Autosomal Dominant Polycystic Kidney Disease.
Sun M, Wu Z, Hu M, Luo W, Chen X, Ma M
Cells 2026 Feb 4;15(3)
Cells 2026 Feb 4;15(3)
Investigating the mechanisms by which bisphenol A affects osteoarthritis through a novel network toxicology framework and experimental validation.
He Q, Li S, Chen Y, Liu Y, Li Y, Min S, Yi S, Li F, Zhou X
BMC pharmacology & toxicology 2026 Feb 25;27(1)
BMC pharmacology & toxicology 2026 Feb 25;27(1)
Role of lipid rafts in the FGFR2c-mediated oncogenic signaling by involvement of TRPA1 channel in pancreatic ductal adenocarcinoma cells.
Mancini V, Manganelli V, Garofalo T, Sorice M, Raffa S, Scullari D, Ranieri D, Belleudi F
Cell death & disease 2026 Feb 24;17(1)
Cell death & disease 2026 Feb 24;17(1)
PRMT3-mediated post-translational adaptation to fasting regulates metabolic flexibility.
Huang Z, Liu X, Chen X, Zhou Y, Chen Q, Liu Y, Zhu H, Cheng K, Feng Y, Dong M, Song L, Wang L, Liu S, Shan T, Kuang S, Dong Y, Vidal-Puig A, Zhang Y, Jia Z
Nature communications 2026 Feb 2;17(1)
Nature communications 2026 Feb 2;17(1)
Antigen-encoding circular single-stranded DNA for cancer vaccine.
Liu R, Ye R, Hu G, Chen H, Niu M, Wang R, Shuai X, Ji Q, Li Z, Zhang Y, Xu Y, Xie R, Song J
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Feb 18;
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Feb 18;
VDAC1 protein derived from extracellular vesicles promotes paclitaxel resistance in gastric cancer through autophagy and mitophagy.
Bi Y, Wei S, Zhang Z, Wang Y, Wen Y, Wang H, Li K, Zhang C, Wang Y, Zhao L, Sun G
Cancer biology & medicine 2026 Feb 17;23(2):252-75
Cancer biology & medicine 2026 Feb 17;23(2):252-75
Maternal Fine Particulate Matter Exposure Impairs Inguinal White Adipose Tissue Plasticity in Middle-Aged Male Mouse Offspring.
Hu R, Li R, Wang L, Li S, Chu H, Zhang L, Qin L, Sun Q, Liu C
ACS nano 2026 Feb 17;20(6):5054-5071
ACS nano 2026 Feb 17;20(6):5054-5071
Ginkgetin inhibits non-small cell lung cancer via the HSP90-AKT signaling pathway.
Li R, Gao H, Wang M, Zhang Y
Naunyn-Schmiedeberg's archives of pharmacology 2026 Apr;399(7):10815-10830
Naunyn-Schmiedeberg's archives of pharmacology 2026 Apr;399(7):10815-10830
Cytosine base editor-mediated ZSCAN4 ablation impairs zygotic genome activation via epigenetic dysregulation in porcine parthenogenetic embryos.
Bi D, Wang Y, Liu R, Wang S, Mao K, Wu T, Yang S, Zhao J, Wang Y
International journal of biological macromolecules 2026 Apr;354:151451
International journal of biological macromolecules 2026 Apr;354:151451
Recoding multiple rare codons enables the simultaneous incorporation of up to five distinct noncanonical amino acids.
Fang Y, Yu W, Li J, Lao L, Yuan Y, Chen Y, Ding W, Lin S
Nature chemistry 2026 Apr;18(4):695-706
Nature chemistry 2026 Apr;18(4):695-706
Ferritin-Doped Nanoparticles Triggered Tumor-Specific Darkening for Enhanced Photothermal Tumor Ablation and Immune Activation.
Zha H, Liang X, Xi L, Chen J, Zhong W, Yuan Z, Xu M, Zheng Y
Advanced healthcare materials 2026 Apr;15(14):e05119
Advanced healthcare materials 2026 Apr;15(14):e05119
Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis.
Zhang Y, Wang Y, Li B, Li X, Liu C, Chen Y, Tian C, Wang D, Gu X, Jiang C, Wei Y, Ding Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(22):e19563
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(22):e19563
Neuroprotective effects of quercetin in LPS-induced depression: implications for antidepressant therapy.
Sun L, Ding Z, Chen J, Kong Y, Qin Y, Han F, Du L, Liu Y
Progress in neuro-psychopharmacology & biological psychiatry 2026 Apr 17;147:111706
Progress in neuro-psychopharmacology & biological psychiatry 2026 Apr 17;147:111706
GPX4 predicts poor prognosis and regulates tumor proliferation and senescence in colorectal adenocarcinoma.
Zhang YU, Wang Q, Han Y, Piao J, Jin X
Oncology research 2025;33(8):1933-1945
Oncology research 2025;33(8):1933-1945
Ultrasound-Targeted Nanobubbles Codelivering NKP-1339 and miR-142-5p for Synergistic Mitochondrial Immunogenic Cell Death and PD-L1 Inhibition in Cancer Therapy.
Zhang Y, Liu C, Jin S, Xie L, Xiao Q, Yao J
Biomaterials research 2025;29:0232
Biomaterials research 2025;29:0232
Heat shock protein 90 mediates the protective effects of vericiguat on myocardial ischemia/reperfusion injury by inhibiting toll-like receptor 4 and c-Jun N-terminal kinases.
Pan SJ, Chen JY, Wang DX, Meng JJ, Wang M, Zhong GQ, Zeng ZY, Tu RH
Iranian journal of basic medical sciences 2025;28(9):1220-1229
Iranian journal of basic medical sciences 2025;28(9):1220-1229
SESN2 inhibits tubular exosome secretion and diabetic kidney disease progression by restoring the autophagy‒lysosome pathway.
Zheng Z, Chen J, Xue X, Ma X, Zhang S, Wang M, Xue Y, Jia Y
International journal of biological sciences 2025;21(9):4215-4230
International journal of biological sciences 2025;21(9):4215-4230
GDF10 attenuates MASH progression by restoring quiescent hepatic stellate cells via competitive inhibition of TGF-β/SMAD2 signaling.
Peng Y, Lei H, Zhao J, Wang H, Luo Z, Wang D, Shi S, Wang T, Li J, Pang Z, Wang B, Xiong X
International journal of biological sciences 2025;21(15):6997-7012
International journal of biological sciences 2025;21(15):6997-7012
Unveiling the Novel Anti - Tumor Potential of Digitonin, a Steroidal Saponin, in Gastric Cancer: A Network Pharmacology and Experimental Validation Study.
Lu D, Huang L, Weng C
Drug design, development and therapy 2025;19:2653-2666
Drug design, development and therapy 2025;19:2653-2666
Barnesiella intestinihominis improves gut microbiota disruption and intestinal barrier integrity in mice with impaired glucose regulation.
Liu X, Wang L, Huang B, Jiao Y, Guan Y, Nuli R
Frontiers in pharmacology 2025;16:1635579
Frontiers in pharmacology 2025;16:1635579
Fbxo16 mediates degradation of NF-κB p65 subunit and inhibits inflammatory response in dendritic cells.
Sugimoto-Ishige A, Jodo A, Tanaka T
Frontiers in immunology 2025;16:1524110
Frontiers in immunology 2025;16:1524110
Reversed role of CD36 deficiency in high-fat diet or methionine/choline-deficient diet-induced hepatic steatosis and steatohepatitis.
Zhu W, Ma J, Zhang T, Zhu M, Duan Y, Yang X, Chen Y
Frontiers in pharmacology 2025;16:1522177
Frontiers in pharmacology 2025;16:1522177
ASPHD1 Is a tumor-suppressive and prognostic marker in glioma.
Yang J, Gao F, Wang X, Zhang Y, Li S
Frontiers in oncology 2025;15:1694116
Frontiers in oncology 2025;15:1694116
Isowighteone attenuates vascular calcification by targeting HSP90AA1-mediated PI3K-Akt pathway and suppressing osteogenic gene expression.
Mo Y, Jin A, Hong W, Peng J, Yang R, Song Q, Liu Y, Cheng Y, Wong WT, Huang Q, Jiang L, Xu Z, Tan N
Frontiers in bioengineering and biotechnology 2025;13:1636883
Frontiers in bioengineering and biotechnology 2025;13:1636883
Ginsenoside Rg5 enhances Abemaciclib sensitivity in ER+ breast cancer by modulating cell cycle proteins via transcriptional and post-translational levels.
Chen J, Liao D, Wu C, Liu L, Luo J, Li G, Cao L
Journal of ginseng research 2025 Sep;49(5):594-603
Journal of ginseng research 2025 Sep;49(5):594-603
Hepatic ASPG-mediated lysophosphatidylinositol catabolism impairs insulin signal transduction.
Li F, Huang HS, Zhao Q, Zhang W, Shi T, Lv W, Zhu Q, Liu H, Xu Y, Huang H, Tang QQ, Gao Y, Peng T, Pan D
The EMBO journal 2025 Sep;44(18):5005-5036
The EMBO journal 2025 Sep;44(18):5005-5036
Roles of human SPATA3 in cell proliferation and expression pattern of Spata3 in mouse testis.
Fu L, Zhou B, Jiang X, Cheng J, Wu Q, Fu J
Molecular medicine reports 2025 Sep;32(3)
Molecular medicine reports 2025 Sep;32(3)
METTL3 Silencing Suppresses Cardiac Fibrosis Post Myocardial Infarction via m6A Modification of SMOC2.
He Y, Pan X, Liu Z, Zuo P, Sheng Z, Hao C, Tao Z, Chen Z, Song J, Ma G, Ling S
Journal of cellular and molecular medicine 2025 Sep;29(17):e70829
Journal of cellular and molecular medicine 2025 Sep;29(17):e70829
Photodynamic enhancement of PROTAC prodrug activation in hypoxic tumors.
Fu Z, Yang C, Yang Y, Pan M, Hou H, Li J
Acta pharmaceutica Sinica. B 2025 Sep;15(9):4945-4960
Acta pharmaceutica Sinica. B 2025 Sep;15(9):4945-4960
Dihydrotanshinone I, a main compound of Salvia miltiorrhiza, alleviates autoimmune and inflammatory diseases by directly targeting IRF3.
Shi W, Wen J, Gao Y, Liu T, Li H, Yang H, Zhao J, Wei Z, Li C, Yao Q, Xiao X, Bai Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157005
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157005
Epoxide hydrolases are involved in the metabolism of 5(6)-epoxyeicosatrienoic acid.
Zhou X, Liu YN, Yin HH, Liu JY
Biochemical and biophysical research communications 2025 Sep 8;778:152394
Biochemical and biophysical research communications 2025 Sep 8;778:152394
Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps.
He D, Wu Q, Tian P, Liu Y, Jia Z, Li Z, Wang Y, Jin Y, Luo W, Li L, Zhang P, Jin Q, Zhao W, Hu W, Liang Y, Zhou B, Yang Q, Jiang YZ, Shao ZM, Hu G
Cancer cell 2025 Sep 8;43(9):1622-1636.e7
Cancer cell 2025 Sep 8;43(9):1622-1636.e7
A Preliminary Study of the Relationship Between Zinc and the AhR Signaling Pathway During Palatal Development.
Liang S, Zhai Y, Chen Z, Yang J, Shu X, Luo J, Wang N, Wang F, Song Q
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2025 Sep 8;:10556656251375952
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2025 Sep 8;:10556656251375952
Hepatocyte FAM210A deficiency disrupts mitochondrial function and triggers juvenile steatosis with compensatory repair in adulthood.
Wang Y, Chu L, Zhou Y, Jin Z, Kim K, Heiden K, Gutierrez-Monreal MA, Ren J, Li Y, Cheng Z, Basso KB, Esser KA, Ryan TE, Yue F
bioRxiv : the preprint server for biology 2025 Sep 4;
bioRxiv : the preprint server for biology 2025 Sep 4;
Clinical, neuropathological, and biochemical characterization of ALS in a large CHCHD10 R15L family.
Kwan JY, Lantz CI, Korobeynikov VA, Snyder A, Huang X, Haselhuhn T, Dore KN, Madruga A, Danielian LE, Schindler AB, Chia R, Rasheed M, Crook J, Szabo M, Portley M, Sherer CM, King MC, Huang TH, Kosa P, Bielekova B, Ward ME, Grunseich C, Shneider NA, Traynor BJ, Narendra DP
medRxiv : the preprint server for health sciences 2025 Sep 26;
medRxiv : the preprint server for health sciences 2025 Sep 26;
SHP2 genetic variants in NSML-associated RASopathies disrupt the PZR-IRX transcription factor signaling axis.
Perla S, Stiegler AL, Yi JS, Enyenihi L, Zhang L, Riaz M, An E, Qyang Y, Boggon TJ, Bennett AM
Proceedings of the National Academy of Sciences of the United States of America 2025 Sep 2;122(35):e2503631122
Proceedings of the National Academy of Sciences of the United States of America 2025 Sep 2;122(35):e2503631122
LncRNA AC021683.2 promotes chemotherapy resistance in acute myeloid leukemia.
Li L, An XN, Ruan YT, Liang X, Hao JL, Gao GX, Bi JF, Gao YR, Lu X, Tang HL, Gao P, Dong XM
iScience 2025 Sep 19;28(9):113439
iScience 2025 Sep 19;28(9):113439
Magnesium ions attenuate tendon graft fibrosis during its ligamentization after ACL reconstruction through modulation of fibroblast to myofibroblast trans-differentiation by promoting PGE2 secretion.
Xu C, Luo Y, Cai Z, Ji J, Guo Z, Cai Z, You C, Zhou Y, Chen Z, Zhang W, Gong N, Wang J
Bioactive materials 2025 Oct;52:474-491
Bioactive materials 2025 Oct;52:474-491
Dual-Functional Silicon-Based Nanofluorescent Platform for Iron Detection and Capecitabine Delivery in Colorectal Cancer Treatment.
Fang X, Wang T, Zhang Y, Song J
Journal of fluorescence 2025 Oct;35(10):9559-9571
Journal of fluorescence 2025 Oct;35(10):9559-9571
Streptococcus pyogenes EVs induce the alternative inflammasome via caspase-4/-5 in human monocytes.
Krause K, Franch Arroyo S, Ugolini M, Kueck T, Sullivan TJ, Gálvez EJC, Muenzner M, Goosmann C, Brinkmann V, Frese CK, Alagesan K, Vierbuchen T, Heine H, Resch U, Sander LE, Charpentier E
EMBO reports 2025 Oct;26(19):4847-4885
EMBO reports 2025 Oct;26(19):4847-4885
Guanosine enhances thermogenesis and impairs KEAP1-mediated NRF2 degradation to resist ferroptosis in brown adipose tissue.
Tang Y, Zhao M, Wang N, Nie H, Song J, Zhou Z, Tang W, Zhang J, Li C, Fang L
Free radical biology & medicine 2025 Oct;238:360-369
Free radical biology & medicine 2025 Oct;238:360-369
Salvia miltiorrhiza water extract ameliorated cGAS-STING-mediated acute liver injury by blocking interaction between STING and TBK1.
Li C, Xu R, Zhang M, Chen S, Yao Q, Zheng C, Wang X, Wen X, Xiao X, Wang Y, Bai Z
Chinese herbal medicines 2025 Oct;17(4):768-778
Chinese herbal medicines 2025 Oct;17(4):768-778
HSP90 Mediates Targeted Degradation of Nonclient Protein PARP1 for Breast Cancer Treatment.
Liu W, Liu J, Shu H, Zhang L, Yin X, Xu X, You Q, Wang L
Journal of medicinal chemistry 2025 Oct 9;68(19):19933-19954
Journal of medicinal chemistry 2025 Oct 9;68(19):19933-19954
IRE1α translational suppression potentiates STING-dependent chemoresistance in pancreatic cancer.
Luo Y, Sun M, Chang L, He Z, Zhou X, Yuan Y, Sun H, Luo S, Huang J, Wu H, Liu W, Zhou Z, Mao Y, Ji Y, Liang T
Cell death & disease 2025 Oct 6;16(1):680
Cell death & disease 2025 Oct 6;16(1):680
Gold-Decorated Upconversion Luminescent Nanozyme Enables ROS-Responsive Antioxidant for Myocardial Injury Repair.
Li Y, Li Y
ACS applied materials & interfaces 2025 Oct 29;17(43):59198-59210
ACS applied materials & interfaces 2025 Oct 29;17(43):59198-59210
Exploring the mechanism of volatile organic compounds in respiratory tract tumors based on network toxicology and molecular simulation.
Ding R, Quan Q, Dai Q, Quan T, Huang R, Xie D, Long Z
The Science of the total environment 2025 Oct 25;1001:180500
The Science of the total environment 2025 Oct 25;1001:180500
Novel E-F ring derivatives of aconitine scaffold as potent Hsp90 inhibitors for the treatment of colorectal cancer.
Zhang Y, Wang YP, Guo S, Li TT, Wang QY, Zhang X, Zheng YM, Wen YQ, Meng FH, Zhang TJ
European journal of medicinal chemistry 2025 Oct 15;296:117895
European journal of medicinal chemistry 2025 Oct 15;296:117895
Small Extracellular Vesicles Derived from NF2-Associated Schwannoma Cells Modulate Tumor Progression and Immunity via HSP90.
Wang Y, Ren Y, Zhang Q, Zhang C, Yan M, Ma X, Wang B, Li P, Liu P
Current oncology (Toronto, Ont.) 2025 Oct 13;32(10)
Current oncology (Toronto, Ont.) 2025 Oct 13;32(10)
A Phototherapy Nanosensitizer-Unlocked Multihit Strategy to Inhibit Tumor Stemness and Potentiate Sorafenib Response in Hepatocellular Carcinoma.
Qin T, Lu H, Wang Q, Deng Y, Zeng J, Chen Y, Liao X
ACS applied materials & interfaces 2025 Oct 1;17(39):54537-54552
ACS applied materials & interfaces 2025 Oct 1;17(39):54537-54552
The deubiquitinase USP17LA negatively regulates T-cell activation and attenuates anti-tumor immunity.
Zhang H, Guo Z, Wei G, Yi J, Wang Z, Zhang Y, Zhao H, Ren T, Wang Y, Kuang J, Sheng Z, Zhang D
EMBO reports 2025 Nov;26(21):5300-5325
EMBO reports 2025 Nov;26(21):5300-5325
Bald disease in a natural population of the purple sea urchin Paracentrotus lividus of the Mediterranean Sea: From spines to tissues.
Carella F, Correggia M, Cordone A, Iacovino O, Maresca F, Villari G, Roque A, Vico G
Journal of invertebrate pathology 2025 Nov;213:108415
Journal of invertebrate pathology 2025 Nov;213:108415
Andrographolide Promotes Ferroptosis in Pancreatic Cancer via Targeting and Activating HSP90/GPX4 Ubiquitination.
Ullah A, Xing H, Wang X, Zhou C, Rui Z, Iqbal H, Chengfeng X, Khan ZU, Khan NU, Jin ZM
BioFactors (Oxford, England) 2025 Nov-Dec;51(6):e70063
BioFactors (Oxford, England) 2025 Nov-Dec;51(6):e70063
Gallic acid lessens kidney injury induced by inorganic arsenic and zinc oxide nanoparticles in rats via controlling electrolyte balance, oxidative stress, and Nrf-2 and HSP-90 expression.
Abd-Elhakim YM, Hashem MMM, Abo-El-Sooud K, Mousa MR, Hassan BA
BMC pharmacology & toxicology 2025 Nov 29;26(1):206
BMC pharmacology & toxicology 2025 Nov 29;26(1):206
Enhancer regulator MLL4 controls skeletal muscle metabolic efficiency by limiting AMPK-mediated fuel catabolism.
Yang L, Liu L, Wang W, Ding C, Asokan AK, Feng T, Zhou D, Xu Z, Fu T, Guo Q, Zhou Z, Pei S, Shen G, Xiao L, Yin Y, Sun Z, Mao Y, Sun W, Li J, Xue J, Zhu MS, Ge K, Sreekumaran Nair K, Piao HL, Gan Z
Nature communications 2025 Nov 26;16(1):11644
Nature communications 2025 Nov 26;16(1):11644
Quercetin ameliorates doxorubicin-induced atrial fibrillation via EGFR-mediated restoration of autophagic flux.
Bian WH, Wang SH, Kang ZC, Xu Y, Li YN, Yang MZ, Yang JH, Liu JY, Cheng YL, Chang D, Xie X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157357
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157357
Quercetin as a Novel Antidepressant: Mechanistic Insights into Its Neuroprotective and Anti-inflammatory Effects.
Fan X, Wang Z, Sun L, Qin Y, Liu Y, Wu S, Du L
Molecular neurobiology 2025 Nov 24;63(1):155
Molecular neurobiology 2025 Nov 24;63(1):155
The novel selective HDAC1 inhibitor ZJH-1 exhibits potent antitumor activity in castration-resistant prostate cancer, potentially involving HSP90AA1.
Bao Y, Li J, Zhang A, Ni Y, Bi M, Chen J
Chemico-biological interactions 2025 Nov 1;421:111777
Chemico-biological interactions 2025 Nov 1;421:111777
Brigatinib activates inflammasomes: Implication for immune-related adverse events.
Noda T, Tanaka S, Maruta Y, Haruna M, Mizuguchi S, Fujimoto A, Urashima K, Kohda Y, Kato R
Toxicology and applied pharmacology 2025 May;498:117310
Toxicology and applied pharmacology 2025 May;498:117310
DNMT3B inhibits PCV2 replication via targeting TMEM37 to regulate Ca(2 +) influx in PK15 cells.
Du X, Xiao Q, Yang L, Shan Y, Hu Y, Bao W, Wu S, Wu Z
Veterinary microbiology 2025 May;304:110480
Veterinary microbiology 2025 May;304:110480
Genetic mutation in HSF4 is associated with retinal degeneration in mice.
Liu B, Lang Y, Li Y, Jiang M, Xue M, Jia X, Peng X, Hu Y
Experimental eye research 2025 May;254:110316
Experimental eye research 2025 May;254:110316
Methionine is an essential amino acid in doxorubicin-induced cardiotoxicity through modulating mitophagy.
Xin Y, Zhang Y, Yuan Z, Li S
Free radical biology & medicine 2025 May;232:28-39
Free radical biology & medicine 2025 May;232:28-39
A cardiac fibroblast-enriched micropeptide regulates inflammation in ischemia/reperfusion injury.
Yan Y, Zhang T, He X, Du T, Dai G, Xu X, Chen Z, Wu J, Zhou H, Peng Y, Li Y, Liu C, Liao X, Dong Y, Ou JS, Huang ZP
JCI insight 2025 May 8;10(9)
JCI insight 2025 May 8;10(9)
Advanced Paternal Age and Sperm Proteome Dynamics: A Possible Explanation for Age-Associated Male Fertility Decline.
Santiago J, Silva JV, Santos MAS, Fardilha M
Cells 2025 May 30;14(11)
Cells 2025 May 30;14(11)
hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer.
Qin F, Wang Y, Yang C, Ren Y, Wei Q, Tang Y, Xu J, Wang H, Luo F, Luo Q, Luo X, Liu X, Yang D, Zuo X, Yang Y, Cheng C, Xu J, Wang W, Liu T, Yi P
Nature communications 2025 May 24;16(1):4828
Nature communications 2025 May 24;16(1):4828
Accelerated differentiation of photothermal effect-induced mesenchymal stem cells regulated by activating HSP90-autophagy boosts wound repair.
Li XY, Ding DP, Zhan MY, Ma TQ, Zhao XY, Zheng L, Han N, Leng F, Mao YC, Li Z, Wei W, Tan Y, Tang JM, Li TF
International journal of pharmaceutics 2025 May 15;676:125631
International journal of pharmaceutics 2025 May 15;676:125631
Anemarrhena asphodeloides Bunge and Phellodendri Chinensis Cortex inhibits the PTGS2/EP2/cAMP/Epac1 signaling pathway to reduce microglial M1 polarization, thereby blocking chronic stress-induced depression-like behavior.
Zhao DP, Xue A, Yuan K, Zuo K, Li Y, Bian ZH, Xu HD, Cheng SM, Yang M, Zhao HM, Ma X, Lei X, Zhang N
Journal of ethnopharmacology 2025 May 12;347:119792
Journal of ethnopharmacology 2025 May 12;347:119792
Tea Polyphenols Mitigate Radiation-Induced Ferroptosis and Intestinal Injury by Targeting the Nrf2/HO-1/GPX4 Signaling Pathway.
Li R, Li L, Wu H, Gan H, Wu Z, Gu R, Zhu X, Liu S, Meng Z, Dou G
Antioxidants (Basel, Switzerland) 2025 May 11;14(5)
Antioxidants (Basel, Switzerland) 2025 May 11;14(5)
FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation.
Xiao D, Ran H, Chen L, Li Y, Cai Y, Zhang S, Qi Q, Wu H, Zhang C, Cao S, Mi L, Huang H, Qi J, Han Q, Tu H, Li H, Zhou T, Li F, Li A, Man J
Science China. Life sciences 2025 Mar;68(3):673-688
Science China. Life sciences 2025 Mar;68(3):673-688
COPB1 deficiency triggers osteoporosis with elevated iron stores by inducing osteoblast ferroptosis.
Wang Y, Zhang R, Wang A, Wang X, Wang X, Zhang J, Liu G, Huang K, Liu B, Hu Y, Pan S, Ruze X, Zhai Q, Xu Y
Journal of orthopaedic translation 2025 Mar;51:312-328
Journal of orthopaedic translation 2025 Mar;51:312-328
SLC13A2 promotes hepatocyte metabolic remodeling and liver regeneration by enhancing de novo cholesterol biosynthesis.
Shi L, Chen H, Zhang Y, An D, Qin M, Yu W, Wen B, He D, Hao H, Xiong J
The EMBO journal 2025 Mar;44(5):1442-1463
The EMBO journal 2025 Mar;44(5):1442-1463
Bisdemethoxycurcumin mitigates traumatic brain injury in rats by modulating autophagy and oxidative stress via heat shock protein 90 alpha family class A member 1-mediated nuclear translocation of transcription factor EB.
Xu Y, Peng LS, Xiao CQ, Zhou Y, Wang QS, Fu H
Brain research bulletin 2025 Mar;222:111221
Brain research bulletin 2025 Mar;222:111221
Interleukin-37 promotes wound healing in diabetic mice by inhibiting the MAPK/NLRP3 pathway.
Cui Q, Zhang Z, Qin L, Teng Z, Wang Z, Wu W, Fan L, Su J, Hao Y, Qin J, Zhang L, Wang Q, Zhuang Y, Zheng H, Zhang S, Geng X, Zhu L, Chen Y, Lu B, Li Y, Zhu X
Journal of diabetes investigation 2025 Mar;16(3):405-413
Journal of diabetes investigation 2025 Mar;16(3):405-413
Excessive MYC Orchestrates Macrophages induced Chromatin Remodeling to Sustain Micropapillary-Patterned Malignancy in Lung Adenocarcinoma.
Song X, Pan Z, Zhang Y, Yang W, Zhang T, Wang H, Chen Y, Yu X, Ding H, Li R, Ge P, Xu L, Dong G, Jiang F
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2403851
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2403851
Inhibiting HMGB1/AGER/NF-κB pathway prevents pro-inflammatory microglia polarization and protect photoreceptors in retinitis pigmentosa.
Hu C, Cui T, Xu Z, Yang K, Wu Y, Cai W, Yu J, Qiu Y
International immunopharmacology 2025 Mar 6;149:114192
International immunopharmacology 2025 Mar 6;149:114192
FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology.
Yu L, Yang YX, Gong Z, Wan Q, Du Y, Zhou Q, Xiao Y, Zahr T, Wang Z, Yu Z, Yang K, Geng J, Fried SK, Li J, Haeusler RA, Leong KW, Bai L, Wu Y, Sun L, Wang P, Zhu BT, Wang L, Qiang L
Cell metabolism 2025 Mar 4;37(3):656-672.e7
Cell metabolism 2025 Mar 4;37(3):656-672.e7
Endophilin B1 is essential for maintaining cardiac function by regulating mitocytosis.
Deng J, Chang X, Zhang X, Li C, Guo G, Song H, Zheng Y, Zhang C, Yang B, Zhang C, Xing P, Zhang Z, Yin T, Tao L, Wang S
Cellular and molecular life sciences : CMLS 2025 Mar 26;82(1):130
Cellular and molecular life sciences : CMLS 2025 Mar 26;82(1):130
Phenethyl isothiocyanate ameliorates liver injuries secondary to inflammatory bowel disease.
Ma C, Zhang L, Huang Q, Deng Q, Huang F, Xu J
Food & function 2025 Mar 17;16(6):2589-2597
Food & function 2025 Mar 17;16(6):2589-2597
Targeting USP8 causes synthetic lethality through degradation of FGFR2 in ARID1A-deficient ovarian clear cell carcinoma.
Saito R, Fukushima M, Sasaki M, Okamoto A, Ogiwara H
NPJ precision oncology 2025 Mar 12;9(1):69
NPJ precision oncology 2025 Mar 12;9(1):69
Microenvironment-induced programmable nanotherapeutics restore mitochondrial dysfunction for the amelioration of non-alcoholic fatty liver disease.
Zhang J, Yang W, Zhu Y, Li Z, Zheng Y, Zhang Y, Gao W, Zhang X, Wu Z, Gao L
Acta biomaterialia 2025 Mar 1;194:323-335
Acta biomaterialia 2025 Mar 1;194:323-335
Angiotensin 1-7 Attenuates the Development of Ischemia-Reperfusion-Induced Arrhythmia in Rats: Electrophysiology, Molecular, and Immunohistochemical Study.
Boushra AF, Soliman GF, Ibrahim W, Rashed LA, El-Meguid EAA, Abouelela YS, Yasin NAE, Gomaa E, Ali E, Bastawy N
Microscopy research and technique 2025 Jun;88(6):1643-1653
Microscopy research and technique 2025 Jun;88(6):1643-1653
Meg3-NONO-RAR axis mediates RA pathway activation in TCDD-induced cleft palate.
Yu Z, Su H, Gao Z, Chen Y, Zhang Y, Duan W, Zhang T, Wang X, Xu D, Liu X
Toxicology 2025 Jun;514:154099
Toxicology 2025 Jun;514:154099
Endoscopic nasal delivery of engineered endothelial progenitor cell-derived exosomes improves angiogenesis and neurological deficits in rats with intracerebral hemorrhage.
Wan G, Li Z, Gu L, Sun Y, Wang Y, Wang Y, Geng R, Chen Y, Ma W, Bao X, Wang R
Materials today. Bio 2025 Jun;32:101652
Materials today. Bio 2025 Jun;32:101652
Black phosphorus nanosheets activate tumor immunity of glioblastoma by modulating the expression of the immunosuppressive molecule PD-L1.
Xiong Y, He C, Qi J, Xiong M, Liu S, Zhao J, Li Y, Liu G, Deng W
Biomaterials 2025 Jun;317:123062
Biomaterials 2025 Jun;317:123062
α‑ketoglutarate protects against septic cardiomyopathy by improving mitochondrial mitophagy and fission.
Wu W, Ma Q, Li BT, Shi S, Guan GC, Wang JK, Xue BY, Liu ZW
Molecular medicine reports 2025 Jun;31(6)
Molecular medicine reports 2025 Jun;31(6)
Taurine Alleviates Pancreatic β-Cell Senescence by Inhibition of p53 Pathway.
Wang B, Wang Z, Yang Y, Ho MYM, Yang R, Yang H, Liu S, Lin H, Cheng KKY, Li X
Journal of diabetes 2025 Jun;17(6):e70100
Journal of diabetes 2025 Jun;17(6):e70100
GART promotes multiple myeloma malignancy via tumor stemness mediated by activating the HSP90α/CDK6/β-catenin axis.
Qian J, Meng H, Wang Z, Sun Y, Xu X, Shi H, Wang C, Zhou L, Lv X, Yang Y, Gu C
European journal of pharmacology 2025 Jun 5;996:177584
European journal of pharmacology 2025 Jun 5;996:177584
Erzhi pill promotes norepinephrine synthesis in locus coeruleus through ERβ-TFAP2A-TH plays a neuroprotective role.
Xue A, Zhao D, Xu H, Lei X, Li D, Ren Y, Zhou Q, Qiu Q, Cai L, Zhang Y, Zhang N
Journal of ethnopharmacology 2025 Jun 26;350:120015
Journal of ethnopharmacology 2025 Jun 26;350:120015
Extrusion fountains are restricted by WAPL-dependent cohesin release and CTCF barriers.
Liu NQ, Magnitov M, Schijns MMGA, van Schaik T, Teunissen H, van Steensel B, de Wit E
Nucleic acids research 2025 Jun 20;53(12)
Nucleic acids research 2025 Jun 20;53(12)
An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis.
Zhang Y, Wang J, Yi C, Su Y, Yin Z, Zhang S, Jin L, Stoneking M, Yang J, Wang K, Huang H, Li J, Fan S
Cell genomics 2025 Jun 11;5(6):100855
Cell genomics 2025 Jun 11;5(6):100855
Oxaliplatin accelerates immunogenic cell death by activating the cGAS/STING/TBK1/IRF5 pathway in gastric cancer.
Zhao S, Sun D, Yu H, Wang M, Xu B, Wang Y, Hu F, Wang X, Zhang J, Wang Y, Chai J
The FEBS journal 2025 Jul;292(14):3814-3828
The FEBS journal 2025 Jul;292(14):3814-3828
Sex-dependent effects of heat exposure on the middle ear health in mice.
Li J, Fan W, Yuan X, Wan T, Qin L, Zhang L, Hou T, Liu C, Li R
Journal of thermal biology 2025 Jul;131:104198
Journal of thermal biology 2025 Jul;131:104198
Intermediate Filament Protein BFSP1 Maintains Oocyte Asymmetric Division by Modulating Spindle Length.
Li Y, Zhang H, Zeng W, Miao Y, Sun S, Zhang Y, Xiong B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(28):e2504066
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(28):e2504066
Xanthosine alleviates myocardial ischemia-reperfusion injury through attenuation of cardiomyocyte ferroptosis.
Xu Y, Zhou W, Fan Z, Cheng Y, Xiao Y, Liu Y, Li X, Ji Z, Fan Y, Ma G
Cellular & molecular biology letters 2025 Jul 28;30(1):93
Cellular & molecular biology letters 2025 Jul 28;30(1):93
Heat shock protein 90 chaperone activity is required for hepatitis A virus replication.
Li Y, Zheng X, Xie L, Kapustina M, Shirasaki T, Yonish B, Chen X, Hirai-Yuki A, Nagata N, Suzuki R, Isogawa M, Vogt MR, Muramatsu M, Lemon SM
Journal of virology 2025 Jul 22;99(7):e0050225
Journal of virology 2025 Jul 22;99(7):e0050225
Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis.
Liu L, Ma Y, Jian Z, Liao B, Li Y, Lin L, Wang M, Chen J, Wei J, Yang M, Liu Y, Yuan Y, Wen J, Xiang L, Qi S, Jin X, Wang K
Cell reports 2025 Jul 22;44(7):115936
Cell reports 2025 Jul 22;44(7):115936
Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction.
Ye Y, Shen F, Yan M, Zhan C, Lv J, Zou M, Wang Z, Ning S, Gao Y, Wu J, Li W
Cell death & disease 2025 Jul 10;16(1):509
Cell death & disease 2025 Jul 10;16(1):509
Gambogic acid and IR780 self-assembled nanoparticles for combined chemo-phototherapy.
Ruan M, Wang X, Guo M, Hu Z, Hu W, Guo Z, Chen W, Li S, Wu K, Du S, Han N
Colloids and surfaces. B, Biointerfaces 2025 Jan;245:114254
Colloids and surfaces. B, Biointerfaces 2025 Jan;245:114254
Quercetin inhibits hydrogen peroxide-induced cleavage of heat shock protein 90 to prevent glutathione peroxidase 4 degradation via chaperone-mediated autophagy.
Peng C, Li H, Mao Q, Tang K, Sun M, Ai Q, Yang Y, Liu F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156286
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156286
C9ORF72 poly-PR induces TDP-43 nuclear condensation via NEAT1 and is modulated by HSP70 activity.
Agnihotri D, Lee CC, Lu PC, He RY, Huang YA, Kuo HC, Huang JJ
Cell reports 2025 Jan 28;44(1):115173
Cell reports 2025 Jan 28;44(1):115173
Deciphering the Transcriptional Metabolic Profile of Adipose-Derived Stem Cells During Osteogenic Differentiation and Epigenetic Drug Treatment.
Gerini G, Traversa A, Cece F, Cassandri M, Pontecorvi P, Camero S, Nannini G, Romano E, Marampon F, Venneri MA, Ceccarelli S, Angeloni A, Amedei A, Marchese C, Megiorni F
Cells 2025 Jan 17;14(2)
Cells 2025 Jan 17;14(2)
More than just DNA damage: Pt(ΙΙ)-NHC complexes derived from 4,5-diarylimidazoles augment immunogenic cell death.
Tang L, Chang X, Shi J, Wen Z, Bi C, Liu W
European journal of medicinal chemistry 2025 Jan 15;282:117014
European journal of medicinal chemistry 2025 Jan 15;282:117014
Heterogeneous nuclear ribonucleoprotein C promotes non-small cell lung cancer progression by enhancing XB130 mRNA stability and translation.
Wang Q, Gou X, Liu L, Deng D, Zhao Y, Zhou J, Xie Y, Jiang Y, Li J, Zhang J, Liu Y
Cancer cell international 2025 Jan 13;25(1):10
Cancer cell international 2025 Jan 13;25(1):10
Shuangdan Jiedu Decoction improved LPS-induced acute lung injury by regulating both cGAS-STING pathway and inflammasome.
Yao Q, Wen J, Chen S, Wang Y, Wen X, Wang X, Li C, Zheng C, Li J, Ma Z, Zhan X, Xiao X, Bai Z
Journal of ethnopharmacology 2025 Jan 10;336:118661
Journal of ethnopharmacology 2025 Jan 10;336:118661
AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice.
Hu Z, Yang J, Zhang S, Li M, Zuo C, Mao C, Zhang Z, Tang M, Shi C, Xu Y
Neural regeneration research 2025 Jan 1;20(1):253-264
Neural regeneration research 2025 Jan 1;20(1):253-264
RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus.
Pang X, Gu L, Han QY, Xing JQ, Zhao M, Huang SY, Yi JX, Pan J, Hong H, Xue W, Zhou XQ, Su ZH, Zhang XR, Sun LM, Jiang SZ, Luo D, Chen L, Wang ZJ, Yu Y, Xia T, Zhang XM, Li AL, Zhou T, Cai H, Li T
Science China. Life sciences 2025 Feb;68(2):441-453
Science China. Life sciences 2025 Feb;68(2):441-453
Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway.
Xu M, Chen J, Gao L, Cai S, Dong H
Ecotoxicology and environmental safety 2025 Feb;291:117828
Ecotoxicology and environmental safety 2025 Feb;291:117828
Structural Plasticity of RRE Stem-Loop II Modulates Nuclear Export of HIV-1 RNA.
Ojha M, Hudson L, Photenhauer A, Zang T, Lerew L, Ekesan Ş, Daniels J, Nguyen M, Paudyal H, York DM, Ohi MD, Marchant J, Bieniasz PD, Koirala D
bioRxiv : the preprint server for biology 2025 Feb 26;
bioRxiv : the preprint server for biology 2025 Feb 26;
Novel reporter of the PINK1-Parkin mitophagy pathway identifies its damage sensor in the import gate.
Thayer JA, Petersen JD, Huang X, Hawrot J, Ramos DM, Sekine S, Li Y, Ward ME, Narendra DP
bioRxiv : the preprint server for biology 2025 Feb 20;
bioRxiv : the preprint server for biology 2025 Feb 20;
Paeoniflorin Inhibits Porcine Circovirus Type 2 Replication by Inhibiting Autophagy and Targeting AKT/mTOR Signaling.
Wu Z, Yu L, Hu Y, Bao W, Wu S
Veterinary sciences 2025 Feb 2;12(2)
Veterinary sciences 2025 Feb 2;12(2)
Exosomes containing miR-148a-3p derived from mesenchymal stem cells suppress epithelial-mesenchymal transition in lens epithelial cells.
Ma J, Sun Q, Chen Y, Li J, Chen S, Luo L
Stem cells translational medicine 2025 Feb 11;14(2)
Stem cells translational medicine 2025 Feb 11;14(2)
HSP90 co-regulates the formation and nuclear distribution of the glycolytic output complex to promote resistance and poor prognosis in gastric cancer patients.
Shen G, Liu S, Cao Y, Chen Z, Wang G, Yu L, Sun L, Ran Y
Journal of translational medicine 2025 Feb 10;23(1):172
Journal of translational medicine 2025 Feb 10;23(1):172
Non-catalytic mechanisms of KMT5C regulating hepatic gluconeogenesis.
Zhao Q, Cui X, Zhu Q, Li F, Bao R, Shi T, Liu H, Lv W, Xu Y, Gao Y, Tang QQ, Zhang M, Pan D
Nature communications 2025 Feb 10;16(1):1483
Nature communications 2025 Feb 10;16(1):1483
Cadmium exposure induces oxidative stress-mediated necroptosis via TLR4/NF-κB signaling pathway in pig epididymis.
Li Y, Wang S, Wang Y
Environmental pollution (Barking, Essex : 1987) 2025 Feb 1;366:125514
Environmental pollution (Barking, Essex : 1987) 2025 Feb 1;366:125514
The receptor tyrosine kinase ErbB2/HER2 governs CDK4 inhibitor sensitivity, timing, and irreversibility of the G1/S transition.
Nagasato-Ichikawa A, Murakami K, Aoki K, Okada M
The Journal of biological chemistry 2025 Dec;301(12):110865
The Journal of biological chemistry 2025 Dec;301(12):110865
The suprachiasmatic nucleus regulates brown fat thermogenesis in male mice through an adrenergic receptor ADRB3-S100B signaling pathway.
Zeng Y, Song X, Chen Q, Gu Y, Zhang J, Zhou T, Li Z, Wang T, Chang L, Yao H, Wang Y, Miao L, Qian L, Guo T, Zhang Y, Rodriguez-Fernandez S, Vidal-Puig A, Xu Y
PLoS biology 2025 Dec;23(12):e3003534
PLoS biology 2025 Dec;23(12):e3003534
Extracellular vesicles from obese visceral adipose promote pancreatic cancer development and resistance to immune checkpoint blockade therapy.
Xue C, Zhao S, Zhou Y, Chen Z, Liu J, Deng S, Zeng L, Zhao H, Xu Z, Li M, He X, Liu S, Liu S, Zhang S, Peng X, Wu X, Bai R, Zhuang L, Wu S, Zhang J, Lin D, Huang X, Zheng J
Cell metabolism 2025 Dec 2;37(12):2381-2401.e9
Cell metabolism 2025 Dec 2;37(12):2381-2401.e9
Ubiquitination by HRD1 is essential for TLR3 trafficking and its innate immune signaling.
Zhao L, He Z, Sun Y, Sun M, Liu Z, Zhou Z, Qi L, Luo Y, Ji Y, Liang T
Nature communications 2025 Dec 10;17(1):525
Nature communications 2025 Dec 10;17(1):525
Heparanase 1 produced by keratinocytes contributes to psoriatic inflammation by promoting neutrophil infiltration.
Main H, Lobreau F, Chassaing D, Clarhault S, Wierzbicka-Hainaut E, Daviaud C, Cherfan J, Havret R, Lecron JC, Jégou JF, Favot L, Baranger K, Morel F
International immunopharmacology 2025 Dec 10;167:115742
International immunopharmacology 2025 Dec 10;167:115742
Extracellular vesicle-mediated delivery of circp53 suppresses the progression of multiple cancers by activating the CypD/TRAP/HSP90 pathway.
Yu X, Ding P, Guo M, Tang X, Wang Z, Zhang Y, Zhou L, Lv X, Shi H, Huang H, Mao J, Gu Z, Gu C, Yang Y
Experimental & molecular medicine 2025 Aug;57(8):1711-1726
Experimental & molecular medicine 2025 Aug;57(8):1711-1726
Kurarinone Alleviates cGAS-STING-Triggered Inflammatory Diseases by Targeting STING.
Liu L, Wang Z, Qi Y, Huang A, He C, Zhan X, Xiao X, Bai Z
Phytotherapy research : PTR 2025 Aug;39(8):3450-3465
Phytotherapy research : PTR 2025 Aug;39(8):3450-3465
Immunogenic cuproptosis in cancer immunotherapy via an in situ cuproptosis-inducing system.
Li J, Zhang G, Sun Z, Jiang M, Jia G, Liu H, Liu N, Shi L, Zhang L, Nie L, Zhang Y, Fu Y
Biomaterials 2025 Aug;319:123201
Biomaterials 2025 Aug;319:123201
Combining label-free quantitative proteomics and 2D-DIGE to identify the potential targets of Sini Decoction acting on myocardial infarction.
Feng F, Zhang W, Cao Y, Lv D, Chai Y, Guo D, Chen X
Chinese journal of natural medicines 2025 Aug;23(8):1016-1024
Chinese journal of natural medicines 2025 Aug;23(8):1016-1024
Cadmium Exposure Induces Inflammation Through Oxidative Stress-Mediated Activation of the NF-κB Signaling Pathway and Causes Heat Shock Response in a Piglet Testis.
Li Y, Wang H, Wang Y
Biological trace element research 2025 Aug;203(8):4128-4138
Biological trace element research 2025 Aug;203(8):4128-4138
HnRNPR promotes non-small cell lung cancer progression by protecting XB130 mRNA from XRN1- and DIS3L2-mediated degradation.
Wang QR, Liu LL, Gou XJ, Liu Y, Zhao Y, Zhang T, Jiang YH, Zhou JJ, Li JL, Zhang J, Xie Y
Cellular signalling 2025 Aug;132:111816
Cellular signalling 2025 Aug;132:111816
SD49-7 attenuates cardiac hypertrophy by upregulation of S100B through KDM4A inhibition.
Zhang Z, Gao M, Yan T, Feng Z, Lu S, Tang L, Li X, Wang W, Yang P, Zhou S, Hu Y, Duan Y, Zhang S
Biochemical pharmacology 2025 Aug 8;242(Pt 1):117218
Biochemical pharmacology 2025 Aug 8;242(Pt 1):117218
Nanoparticle conjugation of ginsenoside Rh2 enhanced antitumor efficacy on hepatocellular carcinoma.
Sun F, Liu J, Gao S, Zhang M, Sun X, Tian Y, Wang S
Scientific reports 2025 Aug 8;15(1):29111
Scientific reports 2025 Aug 8;15(1):29111
Cardiopulmonary Bypass-Induced IL-17A Aggravates Caspase-12-Dependent Neuronal Apoptosis Through the Act1-IRE1-JNK1 Pathway.
Zhao R, Ma Y, Li S, Li J
Biomolecules 2025 Aug 6;15(8)
Biomolecules 2025 Aug 6;15(8)
GLUTs-Facilitated Targeting BRD4 Degradation in Breast Cancer through Carbohydrate-Conjugated PROTACs.
Gao Y, Ni D, Li Y, Zheng J, Zhang K, Xiao Y, Tang X, Li L, Wang X, Wei Y, He Y, Guo Z, Nie S
Journal of medicinal chemistry 2025 Aug 28;68(16):17046-17064
Journal of medicinal chemistry 2025 Aug 28;68(16):17046-17064
Biomineralized Albumin-Macrocyclic Conjugates for Synergistic Metal Ion-Based Combination Therapy in Cancer Treatment.
Zhang Y, Ke Y, Li S, Cai X, Li S, Shao Y, Chen X, Zhang Z, Sun SK
ACS nano 2025 Aug 26;19(33):30383-30395
ACS nano 2025 Aug 26;19(33):30383-30395
Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation.
Fang R, Bai L, Verheijen BM, Li B, Dong K, Paulo JA, Zhou M, Chu YC, Song Y, Sherman MY, Gygi S, Field CM, Mitchison TJ, Lu Y
Nature communications 2025 Aug 22;16(1):7852
Nature communications 2025 Aug 22;16(1):7852
Browning effect of LncRNA00602 in Ad36-induced differentiated adipocytes.
Gao J, Meng X, Jiao Y, Abudukeremu A, Nuermaimaiti N, Ma W, Li X, Guan Y
Medicine 2025 Aug 22;104(34):e43816
Medicine 2025 Aug 22;104(34):e43816
Integration of Metabolomics, Transcriptomics, and 16s rRNA Sequencing Reveals the Mechanism of Morus alba L. (Sangzhi) Alkaloids (SZ-A) in Improving Cholesterol Metabolism in Diabetic Rats.
Li C, Ma Y, Wen S, Lei L, Huan Y, Zhai J, Xu K, Cao H, Lei L, Feng C, Liu Y, Shen Z, Liu Q, Liu S
ACS omega 2025 Aug 12;10(31):34597-34607
ACS omega 2025 Aug 12;10(31):34597-34607
Exploring the anti-NSCLC mechanism of phillyrin targeting inhibition of the HSP90-AKT pathway.
Duan Q, Li R, Wang M, Cui Z, Zhu X, Chen F, Han F, Ma J
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):3789-3802
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):3789-3802
HSP90 Complex From OLP Lesion Induces T-Cell Polarization via Activation of Dendritic Cells.
Pan L, Chen J, Lai Y, Du G, Wang H, Sun L, Tang G, Wang Y
Oral diseases 2025 Apr;31(4):1228-1236
Oral diseases 2025 Apr;31(4):1228-1236
Hepatoprotective effects of polysaccharide from Morchella esculenta are associated with activation of the AMPK/Sirt1 signaling pathway in mice with NAFLD.
Wang D, Zhang M, Zhang Y, Yin Z, Zhang S, Zhao Z, Duan Y
International journal of biological macromolecules 2025 Apr;301:140444
International journal of biological macromolecules 2025 Apr;301:140444
Targeting HSP90AA1 to overcome multiple drug resistance in breast cancer using magnetic nanoparticles loaded with salicylic acid.
Chen O, Fu L, Wang Y, Li J, Liu J, Wen Y
International journal of biological macromolecules 2025 Apr;298:139443
International journal of biological macromolecules 2025 Apr;298:139443
3-Hydroxypropionaldehyde modulates tryptophan metabolism to activate AhR signaling and alleviate ethanol-induced liver injury.
Liu C, Wang Y, Sheng L, Zhang Y, Luo G, Ruan XZ, Chen Y, Huang M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156445
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156445
Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD.
Zhang F, Yue K, Sun S, Lu S, Jia G, Zha Y, Zhang S, Chou CJ, Liao C, Li X, Duan Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2412903
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2412903
Burn-Induced Gut Microbiota Dysbiosis Aggravates Skeletal Muscle Atrophy by Tryptophan-Kynurenine Mediated AHR Pathway Activation.
Gao S, Leng Y, Qiu Z, Li K, Li J, Peng J, Xie W, Lei S, Xia Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2409296
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2409296
Network Pharmacology Integrated Experimental Validation Uncover Quercetin as the Key Ingredient of Hedyotis diffusa Anti-BRCA.
Chen Q, Xu Y, Ma J, Zhang G, Yin Z, Zhang D, Luo D, Liu Z
Chemical biology & drug design 2025 Apr;105(4):e70112
Chemical biology & drug design 2025 Apr;105(4):e70112
Liraglutide modulates ALCAT1-Mediated cardiolipin remodeling to improve cardiac function in obese mice.
Wang L, Hu T, Zhang R, Shi Y, Wang Y, Xuan Q, Zhou X
Biochemical and biophysical research communications 2025 Apr 5;756:151583
Biochemical and biophysical research communications 2025 Apr 5;756:151583
Estradiol Alleviates Elevated Temperature-Induced Damage in Yak Oviductal Epithelial Cells by Maintaining Endoplasmic Reticulum Calcium Homeostasis.
Ye X, Wang M, Qiu S, Pan Y, Cui Y, Yu S
Animals : an open access journal from MDPI 2025 Apr 30;15(9)
Animals : an open access journal from MDPI 2025 Apr 30;15(9)
An unconventional autophagic pathway that inhibits ATP secretion during apoptotic cell death.
Terraza-Silvestre E, Villamuera R, Bandera-Linero J, Letek M, Oña-Sánchez D, Ramón-Barros C, Moyano-Jimeno C, Pimentel-Muiños FX
Nature communications 2025 Apr 10;16(1):3409
Nature communications 2025 Apr 10;16(1):3409
Polyoxometalates Ameliorate Metabolic Dysfunction-Associated Steatotic Liver Disease by Activating the AMPK Signaling Pathway.
Wang D, Wang J, Yin Z, Gong K, Zhang S, Zha Z, Duan Y
International journal of nanomedicine 2024;19:10839-10856
International journal of nanomedicine 2024;19:10839-10856
Heat acclimation with probiotics-based ORS supplementation alleviates heat stroke-induced multiple organ dysfunction via improving intestinal thermotolerance and modulating gut microbiota in rats.
Li L, Chen J, Wang Y, Pei Y, Ren L, Dai X, Li J, Ma J, Wang M, Chang W, Chen J, Song Q, Xu S
Frontiers in microbiology 2024;15:1385333
Frontiers in microbiology 2024;15:1385333
A rapid and simple non-radioactive assay for measuring uptake by solute carrier transporters.
Song K, Zhang L, Fu X, Li L, Zhu G, Wu M, Zhang W, He J, Zhu S, Dang Y, Liu JY, Chen C, Guo Z
Frontiers in pharmacology 2024;15:1355507
Frontiers in pharmacology 2024;15:1355507
Quercetin Ameliorates Cognitive Impairment in Depression by Targeting HSP90 to Inhibit NLRP3 Inflammasome Activation.
Du L, Fan X, Yang Y, Wu S, Liu Y
Molecular neurobiology 2024 Sep;61(9):6628-6641
Molecular neurobiology 2024 Sep;61(9):6628-6641
Effect of cholesterol-loaded cyclodextrin treatment on boar sperm cryopreservation.
Zhang S, Zhang H, Liu K, Xu X, Qin Y, Xiao L, Zhou C, Wu J, Liu Y, Bai J
Animal bioscience 2024 Sep;37(9):1558-1567
Animal bioscience 2024 Sep;37(9):1558-1567
Zinc-Mediated Endoplasmic Reticulum Stress and Metallothionein Alleviate Arsenic-Induced Cardiotoxicity in Cyprinus Carpio.
Dong H, Song H, Liu Y, Zou H
Biological trace element research 2024 Sep;202(9):4203-4215
Biological trace element research 2024 Sep;202(9):4203-4215
Hsp90 Promotes Gastric Cancer Cell Metastasis and Stemness by Regulating the Regional Distribution of Glycolysis-Related Metabolic Enzymes in the Cytoplasm.
Liu S, Shen G, Zhou X, Sun L, Yu L, Cao Y, Shu X, Ran Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(33):e2310109
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(33):e2310109
Discovery of novel quinoline scaffold selective estrogen receptor degraders (SERDs) for treatment of ER positive breast cancer with enhanced antiproliferative bioactivity through immunogenic cell death (ICD) effects.
Lu Y, Liang Z, Liu L, Zhou Y, Liu C, Zhao Z, Zheng T, Du Q, Liu W
European journal of medicinal chemistry 2024 Sep 5;275:116534
European journal of medicinal chemistry 2024 Sep 5;275:116534
Pentagalloylglucose alleviates acetaminophen-induced acute liver injury by modulating inflammation via cGAS-STING pathway.
Zheng C, Chen Y, He T, Xiu Y, Dong X, Wang X, Wen X, Li C, Yao Q, Chen S, Zhan X, Gao L, Bai Z
Molecular medicine (Cambridge, Mass.) 2024 Sep 27;30(1):160
Molecular medicine (Cambridge, Mass.) 2024 Sep 27;30(1):160
DVL/GSK3/ISL1 pathway signaling: unraveling the mechanism of SIRT3 in neurogenesis and AD therapy.
Dai N, Su X, Li A, Li J, Jiang D, Wang Y
Stem cell research & therapy 2024 Sep 12;15(1):299
Stem cell research & therapy 2024 Sep 12;15(1):299
Roles of m(6)A modification in regulating PPER pathway in cadmium-induced pancreatic β cell death.
Sun Y, Li R, Li W, Zhang N, Liu G, Zhao B, Mei Z, Gu S, He Z
Ecotoxicology and environmental safety 2024 Sep 1;282:116672
Ecotoxicology and environmental safety 2024 Sep 1;282:116672
Platelet membrane-coated oncolytic vaccinia virus with indocyanine green for the second near-infrared imaging guided multi-modal therapy of colorectal cancer.
Huang J, Ji L, Si J, Yang X, Luo Y, Zheng X, Ye L, Li Y, Wang S, Ge T, Tong X, Cai Y, Mou X
Journal of colloid and interface science 2024 Oct;671:216-231
Journal of colloid and interface science 2024 Oct;671:216-231
Biomimetic nanocomplex based corneal neovascularization theranostics.
Ye J, Cheng Y, Wen X, Han Y, Wei X, Wu Y, Chen C, Su M, Cai S, Pan J, Liu G, Chu C
Journal of controlled release : official journal of the Controlled Release Society 2024 Oct;374:50-60
Journal of controlled release : official journal of the Controlled Release Society 2024 Oct;374:50-60
HSP90 Enhances Mitophagy to Improve the Resistance of Car-Diomyocytes to Heat Stress in Wenchang Chickens.
Shi J, Ji Z, Yao X, Yao Y, Li C, Liang Q, Zhang X
International journal of molecular sciences 2024 Oct 30;25(21)
International journal of molecular sciences 2024 Oct 30;25(21)
Exploring the anti-inflammatory and immune regulatory effects of Taohe Chengqi decoction in sepsis-induced lung injury.
Deng M, Chen S, Wu J, Su L, Xu Z, Jiang C, Sheng L, Yang X, Zeng L, Wang J, Dai W
Journal of ethnopharmacology 2024 Oct 28;333:118404
Journal of ethnopharmacology 2024 Oct 28;333:118404
Polo-like kinase 2 promotes microglial activation via regulation of the HSP90α/IKKβ pathway.
Cheng J, Wu L, Chen X, Li S, Xu Z, Sun R, Huang Y, Wang P, Ouyang J, Pei P, Yang H, Wang G, Zhen X, Zheng LT
Cell reports 2024 Oct 22;43(10):114827
Cell reports 2024 Oct 22;43(10):114827
Paraventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits.
Xing M, Li Y, Zhang Y, Zhou J, Ma D, Zhang M, Tang M, Ouyang T, Zhang F, Shi X, Sun J, Chen Z, Zhang WJ, Zhang S, Xie X
Nature communications 2024 Oct 16;15(1):8939
Nature communications 2024 Oct 16;15(1):8939
Legumain-deficient macrophages regulate inflammation and lipid metabolism in adipose tissues to protect against diet-induced obesity.
Zhang W, Wang S, Liu Z, Qian P, Li Y, Wu J
Molecular and cellular endocrinology 2024 Oct 1;592:112283
Molecular and cellular endocrinology 2024 Oct 1;592:112283
Atg16l2 augments Nlrc4 inflammasome activation by facilitating NAIPs-NLRC4 association.
Wen Z, Yuan T, Liu J, Wang D, Ni J, Yan X, Tang J, Tang J, Wu X, Wang Z
European journal of immunology 2024 Nov;54(11):e2451078
European journal of immunology 2024 Nov;54(11):e2451078
DELE1 maintains muscle proteostasis to promote growth and survival in mitochondrial myopathy.
Lin HP, Petersen JD, Gilsrud AJ, Madruga A, D'Silva TM, Huang X, Shammas MK, Randolph NP, Johnson KR, Li Y, Jones DR, Pacold ME, Narendra DP
The EMBO journal 2024 Nov;43(22):5548-5585
The EMBO journal 2024 Nov;43(22):5548-5585
Mechanism of Gastrodin against neurotoxicity based on network pharmacology, molecular docking and experimental verification.
Guo H, Li C, Zhao J, Guo T, Chen S, Qin X, Zhu K, Zhang W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117611
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117611
Celastrol induces DNA damage and cell death in BCR-ABL T315I-mutant CML by targeting YY1 and HMCES.
Yang F, Zhou H, Luo P, Jia L, Hou M, Huang J, Gao L, Zhang Q, Guan Y, Bao H, Zhang B, Liu L, Zou C, Yang Q, Wang J, Dai L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155937
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155937
Total glucosides of paeony alleviates cGAS-STING-mediated diseases by blocking the STING-IRF3 interaction.
Xiu Y, Wang S, Zhang P, Li C, Wu Z, Wen J, Xu Y, Lv G, Zhao X, Dong X, Chen Y, Li J, Wang Y, Zou L, Xiao X, Bai Z
Chinese journal of natural medicines 2024 May;22(5):402-415
Chinese journal of natural medicines 2024 May;22(5):402-415
Downregulated SPESP1-driven fibroblast senescence decreases wound healing in aged mice.
Zhong Y, Zhou L, Guo Y, Wang F, He F, Cheng Y, Meng X, Xie H, Zhang Y, Li J
Clinical and translational medicine 2024 May;14(5):e1660
Clinical and translational medicine 2024 May;14(5):e1660
Small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery.
Zahr T, Boda VK, Ge J, Yu L, Wu Z, Que J, Li W, Qiang L
Acta pharmaceutica Sinica. B 2024 May;14(5):2137-2152
Acta pharmaceutica Sinica. B 2024 May;14(5):2137-2152
Intermittent mild cold acclimation ameliorates intestinal inflammation and immune dysfunction in acute cold-stressed broilers by regulating the TLR4/MyD88/NF-κB pathway.
Bi Y, Wei H, Chai Y, Wang H, Xue Q, Li J
Poultry science 2024 May;103(5):103637
Poultry science 2024 May;103(5):103637
Identification of immunogenic cell death-related damage-related molecular patterns (DAMPs) to predict outcomes in patients with head and neck squamous cell carcinoma.
Zhang J, Shi X, Wang M, Zhai R, Wang M, Gong Z, Ni Z, Xu T, Zhu W, Liu L
Journal of cancer research and clinical oncology 2024 May 7;150(5):240
Journal of cancer research and clinical oncology 2024 May 7;150(5):240
Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity.
Hurrell BP, Shen S, Li X, Sakano Y, Kazemi MH, Quach C, Shafiei-Jahani P, Sakano K, Ghiasi H, Akbari O
The Journal of experimental medicine 2024 May 6;221(5)
The Journal of experimental medicine 2024 May 6;221(5)
Integrating cryo-OrbiSIMS with computational modelling and metadynamics simulations enhances RNA structure prediction at atomic resolution.
Ward S, Childs A, Staley C, Waugh C, Watts JA, Kotowska AM, Bhosale R, Borkar AN
Nature communications 2024 May 22;15(1):4367
Nature communications 2024 May 22;15(1):4367
HSP90 Inhibition Attenuated Isoflurane-Induced Neurotoxicity in Mice and Human Neuroglioma Cells.
Zhang C, Chen X, Liu R, Zhao G
Neurochemical research 2024 Mar;49(3):706-717
Neurochemical research 2024 Mar;49(3):706-717
TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.
Deng B, Wang J, Yang T, Deng Z, Yuan J, Zhang B, Zhou Z, Chen F, Fang L, Liang C, Yan B, Ai Y
The Journal of cell biology 2024 Mar 4;223(3)
The Journal of cell biology 2024 Mar 4;223(3)
Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.
Muthukumar G, Stevens TA, Inglis AJ, Esantsi TK, Saunders RA, Schulte F, Voorhees RM, Guna A, Weissman JS
Molecular cell 2024 Mar 21;84(6):1101-1119.e9
Molecular cell 2024 Mar 21;84(6):1101-1119.e9
Identification of the Effects of 5-Azacytidine on Porcine Circovirus Type 2 Replication in Porcine Kidney Cells.
Shan Y, Xiao Q, He K, Wu S, Bao W, Wu Z
Veterinary sciences 2024 Mar 20;11(3)
Veterinary sciences 2024 Mar 20;11(3)
A technique for repeated blood and cerebrospinal fluid sampling from individual rats over time without the need for repeated anesthesia.
Santandrea E, Aliakbari F, Truscott E, McCaig L, Donison NS, Graham D, Strong MJ, Volkening K
Scientific reports 2024 Mar 2;14(1):5171
Scientific reports 2024 Mar 2;14(1):5171
The combination of Schisandrin C and Luteolin synergistically attenuates hepatitis B virus infection via repressing HBV replication and promoting cGAS-STING pathway activation in macrophages.
Wu Z, Zhao X, Li R, Wen X, Xiu Y, Long M, Li J, Huang X, Wen J, Dong X, Xu Y, Bai Z, Zhan X, Xiao X
Chinese medicine 2024 Mar 18;19(1):48
Chinese medicine 2024 Mar 18;19(1):48
Endoplasmic reticulum stress impedes regulated secretion by governing key exocytotic and granulogenic molecular switches.
Mukherjee M, Mukherjee C, Ghosh V, Jain A, Sadhukhan S, Dagar S, Sahu BS
Journal of cell science 2024 Mar 15;137(6)
Journal of cell science 2024 Mar 15;137(6)
Ponicidin-induced conformational changes of HSP90 regulates the MAPK pathway to relieve ulcerative colitis.
Zhang X, Xu Y, Fan M, Lv X, Long J, Yang R, Zhang R, Liu Z, Gu J, Wu P, Wang C
Journal of ethnopharmacology 2024 Mar 1;321:117483
Journal of ethnopharmacology 2024 Mar 1;321:117483
Reactive metabolite of trovafloxacin activates inflammasomes: Implications for trovafloxacin-induced liver injury.
Tanaka S, Noda T, Urashima K, Ijiri Y, Kohda Y, Kato R
Journal of applied toxicology : JAT 2024 Jun;44(6):846-852
Journal of applied toxicology : JAT 2024 Jun;44(6):846-852
Neutrophil-derived nanovesicles deliver IL-37 to mitigate renal ischemia-reperfusion injury via endothelial cell targeting.
Ma W, Wu D, Long C, Liu J, Xu L, Zhou L, Dou Q, Ge Y, Zhou C, Jia R
Journal of controlled release : official journal of the Controlled Release Society 2024 Jun;370:66-81
Journal of controlled release : official journal of the Controlled Release Society 2024 Jun;370:66-81
Flavonoid extracted from Epimedium attenuate cGAS-STING-mediated diseases by targeting the formation of functional STING signalosome.
Wang Y, Xu G, Wen J, Zhao X, Zhao H, Lv G, Xu Y, Xiu Y, Li J, Chen S, Yao Q, Chen Y, Ma L, Xiao X, Cao J, Bai Z
Immunology 2024 Jun;172(2):295-312
Immunology 2024 Jun;172(2):295-312
Compound Danshen Dripping Pill effectively alleviates cGAS-STING-triggered diseases by disrupting STING-TBK1 interaction.
Shi W, Xu G, Gao Y, Yang H, Liu T, Zhao J, Li H, Wei Z, Hou X, Chen Y, Wen J, Li C, Zhao J, Zhang P, Wang Z, Xiao X, Bai Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155404
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155404
SAHA/5-AZA Enhances Acetylation and Degradation of mutp53, Upregulates p21 and Downregulates c-Myc and BRCA-1 in Pancreatic Cancer Cells.
Di Crosta M, Ragone FC, Benedetti R, D'Orazi G, Gilardini Montani MS, Cirone M
International journal of molecular sciences 2024 Jun 27;25(13)
International journal of molecular sciences 2024 Jun 27;25(13)
Deciphering ER stress-unfolded protein response relationship by visualizing unfolded proteins in the ER.
Xu F, Wang L
Cell reports 2024 Jun 25;43(6):114358
Cell reports 2024 Jun 25;43(6):114358
CGG repeats in the human FMR1 gene regulate mRNA localization and cellular stress in developing neurons.
Sirois CL, Guo Y, Li M, Wolkoff NE, Korabelnikov T, Sandoval S, Lee J, Shen M, Contractor A, Sousa AMM, Bhattacharyya A, Zhao X
Cell reports 2024 Jun 25;43(6):114330
Cell reports 2024 Jun 25;43(6):114330
MYG1 drives glycolysis and colorectal cancer development through nuclear-mitochondrial collaboration.
Chen J, Duan S, Wang Y, Ling Y, Hou X, Zhang S, Liu X, Long X, Lan J, Zhou M, Xu H, Zheng H, Zhou J
Nature communications 2024 Jun 11;15(1):4969
Nature communications 2024 Jun 11;15(1):4969
GITR exacerbates lysophosphatidylcholine-induced macrophage pyroptosis in sepsis via posttranslational regulation of NLRP3.
Liang S, Zhou J, Cao C, Liu Y, Ming S, Liu X, Shang Y, Lao J, Peng Q, Yang J, Wu M
Cellular & molecular immunology 2024 Jul;21(7):674-688
Cellular & molecular immunology 2024 Jul;21(7):674-688
Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair.
Li J, Dong M, Yao Q, Dong X, Chen Y, Wen J, Xu Y, Wu Z, Zhao X, Xiu Y, Zhan X, Bai Z, Xiao X
Chinese herbal medicines 2024 Jul;16(3):422-434
Chinese herbal medicines 2024 Jul;16(3):422-434
Characterization of HSP90 expression and function following CNS injury.
Fu C, Lei Y, Liang L, Jiang J, Qin Y, Lao Y, Tan Z, Wang Y, Liu Q
Neuroscience letters 2024 Jul 27;836:137875
Neuroscience letters 2024 Jul 27;836:137875
FADD regulates adipose inflammation, adipogenesis, and adipocyte survival.
Tang J, Ma Y, Li M, Liu X, Wang Y, Zhang J, Shu H, Liu Z, Zhang C, Fu L, Hu J, Zhang Y, Jia Z, Feng Y
Cell death discovery 2024 Jul 15;10(1):323
Cell death discovery 2024 Jul 15;10(1):323
Targeting Liver Xor by GalNAc-siRNA Is an Effective Strategy for Hyperuricemia Therapy.
Sun H, Wang X, Li Y, Shen Y, Zhang L, Xu Y, Liu J, Fan X
Pharmaceutics 2024 Jul 14;16(7)
Pharmaceutics 2024 Jul 14;16(7)
HSP90AB1 is a host factor that promotes porcine deltacoronavirus replication.
Zhao Y, Yuan J, Xiao D, Zhang L, Li C, Hu J, Chen R, Song D, Wen Y, Wu R, Zhao Q, Du S, Yan Q, Han X, Wen X, Cao S, Huang X
The Journal of biological chemistry 2024 Jan;300(1):105536
The Journal of biological chemistry 2024 Jan;300(1):105536
Candidate biomarkers in brown adipose tissue for post-mortem diagnosis of fatal hypothermia.
Zhang M, Wang N, Guo XS, Wang LL, Wang PF, Cao ZP, Zhang FY, Wang ZW, Guan DW, Zhao R
International journal of legal medicine 2024 Jan;138(1):61-72
International journal of legal medicine 2024 Jan;138(1):61-72
Chlorogenic acid regulates the expression of NPC1L1 and HMGCR through PXR and SREBP2 signaling pathways and their interactions with HSP90 to maintain cholesterol homeostasis.
Meng C, Zhou L, Huang L, Gu Q, Du X, Wang C, Liu F, Xia C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155271
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155271
Targeting HSP70 chaperones by rhein sensitizes liver cancer to artemisinin derivatives.
Wang J, Zhang J, Guo Z, Hua H, Zhang H, Liu Y, Jiang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155156
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155156
TRPA1 Contributes to FGFR2c Signaling and to Its Oncogenic Outcomes in Pancreatic Ductal Adenocarcinoma-Derived Cell Lines.
Mancini V, Raffa S, Fiorio Pla A, French D, Torrisi MR, Ranieri D, Belleudi F
Cancers 2024 Jan 31;16(3)
Cancers 2024 Jan 31;16(3)
Didymin protects pancreatic beta cells by enhancing mitochondrial function in high-fat diet-induced impaired glucose tolerance.
Yang J, Zou Y, Lv X, Chen J, Cui C, Song J, Yang M, Hu H, Gao J, Xia L, Wang L, Chen L, Hou X
Diabetology & metabolic syndrome 2024 Jan 3;16(1):7
Diabetology & metabolic syndrome 2024 Jan 3;16(1):7
Single-cell and transcriptomic analyses reveal the influence of diabetes on ovarian cancer.
Zhao Z, Wang Q, Zhao F, Ma J, Sui X, Choe HC, Chen P, Gao X, Zhang L
BMC genomics 2024 Jan 2;25(1):1
BMC genomics 2024 Jan 2;25(1):1
The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8(+) T cells.
Liao X, Li W, Zhou H, Rajendran BK, Li A, Ren J, Luan Y, Calderwood DA, Turk B, Tang W, Liu Y, Wu D
Nature communications 2024 Jan 19;15(1):603
Nature communications 2024 Jan 19;15(1):603
Amyloid aggregates induced by the p53-R280T mutation lead to loss of p53 function in nasopharyngeal carcinoma.
Li J, Guo M, Chen L, Chen Z, Fu Y, Chen Y
Cell death & disease 2024 Jan 11;15(1):35
Cell death & disease 2024 Jan 11;15(1):35
Proteolysis Targeting Chimeras (PROTACs) based on celastrol induce multiple protein degradation for triple-negative breast cancer treatment.
Gan X, Wang F, Luo J, Zhao Y, Wang Y, Yu C, Chen J
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Jan 1;192:106624
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Jan 1;192:106624
Self-heating mitochondrion-induced free radical blast for immunogenic cell death stimulation and HCC immunotherapy.
Peng M, Dong H, Shao M, Zhang X, Sun J, Ding C, Han X, Yang Q, Sang X, Cao G
Journal of controlled release : official journal of the Controlled Release Society 2024 Feb;366:694-711
Journal of controlled release : official journal of the Controlled Release Society 2024 Feb;366:694-711
Genetically engineered M2-like macrophage-derived exosomes for P. gingivalis-suppressed cementum regeneration: From mechanism to therapy.
Huang X, Deng Y, Xiao J, Wang H, Yang Q, Cao Z
Bioactive materials 2024 Feb;32:473-487
Bioactive materials 2024 Feb;32:473-487
Ketone bodies promote epididymal white adipose expansion to alleviate liver steatosis in response to a ketogenic diet.
Zhao MF, Zhang XG, Tang YP, Zhu YX, Nie HY, Bu DD, Fang L, Li CJ
The Journal of biological chemistry 2024 Feb;300(2):105617
The Journal of biological chemistry 2024 Feb;300(2):105617
DELE1 promotes translation-associated homeostasis, growth, and survival in mitochondrial myopathy.
Lin HP, Petersen JD, Gilsrud AJ, Madruga A, D'Silva TM, Huang X, Shammas MK, Randolph NP, Li Y, Jones DR, Pacold ME, Narendra DP
bioRxiv : the preprint server for biology 2024 Feb 29;
bioRxiv : the preprint server for biology 2024 Feb 29;
Protective effects of Pt-N-C single-atom nanozymes against myocardial ischemia-reperfusion injury.
Ye T, Chen C, Wang D, Huang C, Yan Z, Chen Y, Jin X, Wang X, Ding X, Shen C
Nature communications 2024 Feb 23;15(1):1682
Nature communications 2024 Feb 23;15(1):1682
Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer.
Rinaldi L, Chiuso F, Senatore E, Borzacchiello D, Lignitto L, Iannucci R, Donne RD, Fuggi M, Reale C, Russo F, Russo NA, Giurato G, Rizzo F, Sellitto A, Santangelo M, De Biase D, Paciello O, D'Ambrosio C, Amente S, Garbi C, Dalla E, Scaloni A, Weisz A, Ambrosino C, Insabato L, Feliciello A
Communications biology 2024 Feb 20;7(1):208
Communications biology 2024 Feb 20;7(1):208
Dysregulation of Glucocorticoid Receptor Homeostasis and Glucocorticoid-Associated Genes in Umbilical Cord Endothelial Cells of Diet-Induced Obese Pregnant Sheep.
Mata-Greenwood E, Chow WL, Anti NAO, Sands LD, Adeoye O, Ford SP, Nathanielsz PW
International journal of molecular sciences 2024 Feb 15;25(4)
International journal of molecular sciences 2024 Feb 15;25(4)
Herpes simplex virus type 1 modifies the protein composition of extracellular vesicles to promote neurite outgrowth and neuroinfection.
Sun G, Kropp KA, Kirchner M, Plückebaum N, Selich A, Serrero M, Dhingra A, Cabrera JR, Ritter B, Bauerfeind R, Wyler E, Landthaler M, Schambach A, Sodeik B, Mertins P, Viejo-Borbolla A
mBio 2024 Feb 14;15(2):e0330823
mBio 2024 Feb 14;15(2):e0330823
Ocular mucoadhesive and biodegradable spanlastics loaded cationic spongy insert for enhancing and sustaining the anti-inflammatory effect of prednisolone Na phosphate; Preparation, I-optimal optimization, and In-vivo evaluation.
Said M, Ali KM, Alfadhel MM, Afzal O, Aldosari BN, Alsunbul M, Bafail R, Zaki RM
International journal of pharmaceutics: X 2024 Dec;8:100293
International journal of pharmaceutics: X 2024 Dec;8:100293
Exploring the role of YBX3 in PEDV infection through the utilization of YBX3 knockout and overexpression cell lines.
Wu J, Gao H, Rui H, Xu P, Ni L, Zhang J, Wang L
Virus genes 2024 Dec;60(6):667-673
Virus genes 2024 Dec;60(6):667-673
The noncanonical RNA-binding protein RAN stabilizes the mRNA of intranuclear stress granule assembly factor G3BP1 in nasopharyngeal carcinoma.
Yang PY, Yang Z, Lv J, Jiang PY, Quan TQ, Huang ZH, Xu XD, Guo R, Wei D, Sun Y
The Journal of biological chemistry 2024 Dec;300(12):107964
The Journal of biological chemistry 2024 Dec;300(12):107964
TGF-β1-mediated upregulation of LMCD1 drives corneal myofibroblast differentiation and corneal fibrosis.
Tang Y, Xu L, Yang Y, Qin F, Meng F, Dai L, Meng Z, Ren S
Experimental eye research 2024 Dec;249:110130
Experimental eye research 2024 Dec;249:110130
Acacetin alleviates rheumatoid arthritis by targeting HSP90 ATPase domain to promote COX-2 degradation.
Wang W, Zhai S, Yang W, Gao H, Chang N, Zhang M, Hou Y, Bai G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156171
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156171
The deubiquitinase OTUB1 inhibits gluconeogenesis by stabilizing YWHAB.
Zhao Q, Wang Q, Li B, Han S, Zhang Y, Wang Y, Lu R, Chen Q, Sun Z, Ding M, Liang Z, Gao Y
Cellular signalling 2024 Dec;124:111408
Cellular signalling 2024 Dec;124:111408
Zbtb7b defines a compensatory mechanism in MASLD-related HCC progression by suppressing H19-mediated hepatic lipid deposition.
Han Y, Wu K, Peng X, Fu Y, Li W, Ma J, Jiang H, Zhao XY
Physiological reports 2024 Dec;12(24):e70160
Physiological reports 2024 Dec;12(24):e70160
Silk fibroin microneedles loaded with epigallocatechin gallate mitigate atrazine-induced testicular toxicity.
Fang C, Li Y, He G, Gan RY, Luo F, Lei L, Hou X, Ye Y
Journal of hazardous materials 2024 Dec 5;480:136252
Journal of hazardous materials 2024 Dec 5;480:136252
Cyberpharmacology uncover the mechanism of the total Rhizoma Coptidis extracts ameliorate chronic atrophic gastritis.
Ma Z, Chen X, Xiong M, Wang H, Sun C, Tang W, Li J, Li X, Ma H, Ye X
Journal of ethnopharmacology 2024 Dec 5;335:118644
Journal of ethnopharmacology 2024 Dec 5;335:118644
Functional anatomy of zinc finger antiviral protein complexes.
Bohn JA, Meagher JL, Takata MA, Gonçalves-Carneiro D, Yeoh ZC, Ohi MD, Smith JL, Bieniasz PD
Nature communications 2024 Dec 30;15(1):10834
Nature communications 2024 Dec 30;15(1):10834
PPDPF promotes esophageal squamous cell carcinoma progression by blocking PCCA binding to PCCB and inhibiting methionine catabolism.
Li M, Zhang Y, Wang Z, Wang K, Gao J, Gu H, Zeng Z, Jiang H, Fan Q, Zhang Y, Hu X, Cui L, Deng Y, Sun Y
Cancer letters 2024 Dec 16;611:217402
Cancer letters 2024 Dec 16;611:217402
Dihydroartemisinin-driven TOM70 inhibition leads to mitochondrial destabilization to induce pyroptosis against lung cancer.
Li LG, Hu J, Han N, Chen NN, Yu TT, Ren T, Xu HZ, Peng XC, Li XY, Ma TQ, Chen H, Zhang L, Chen X, Wang MF, Li TF
Phytotherapy research : PTR 2024 Aug;38(8):3856-3876
Phytotherapy research : PTR 2024 Aug;38(8):3856-3876
A small protein encoded by PCBP1-AS1 is identified as a key regulator of influenza virus replication via enhancing autophagy.
Chi X, Huang G, Wang L, Zhang X, Liu J, Yin Z, Guo G, Chen Y, Wang S, Chen JL
PLoS pathogens 2024 Aug;20(8):e1012461
PLoS pathogens 2024 Aug;20(8):e1012461
Epigenome-wide impact of MAT2A sustains the androgen-indifferent state and confers synthetic vulnerability in ERG fusion-positive prostate cancer.
Cacciatore A, Shinde D, Musumeci C, Sandrini G, Guarrera L, Albino D, Civenni G, Storelli E, Mosole S, Federici E, Fusina A, Iozzo M, Rinaldi A, Pecoraro M, Geiger R, Bolis M, Catapano CV, Carbone GM
Nature communications 2024 Aug 6;15(1):6672
Nature communications 2024 Aug 6;15(1):6672
Exploring the Effects and Potential Mechanisms of Hesperidin for the Treatment of CPT-11-Induced Diarrhea: Network Pharmacology, Molecular Docking, and Experimental Validation.
Shu X, Xu R, Xiong P, Liu J, Zhou Z, Shen T, Zhang X
International journal of molecular sciences 2024 Aug 28;25(17)
International journal of molecular sciences 2024 Aug 28;25(17)
Extreme Heat Exposure Induced Acute Kidney Injury through NLRP3 Inflammasome Activation in Mice.
Wang J, Wang K, Shi X, Hu Z, Zhao L, Chen K, Zhang L, Li R, Zhang G, Liu C
Environment & health (Washington, D.C.) 2024 Aug 16;2(8):563-571
Environment & health (Washington, D.C.) 2024 Aug 16;2(8):563-571
Total tanshinones ameliorates cGAS-STING-mediated inflammatory and autoimmune diseases by affecting STING-IRF3 binding.
Li C, Wen J, Zhan X, Shi W, Ye X, Yao Q, Chen S, Zheng C, Wang X, Wen X, Xiao X, Wang Y, Bai Z
Chinese medicine 2024 Aug 15;19(1):107
Chinese medicine 2024 Aug 15;19(1):107
Characterization of Novel PHEX Variants in X-linked Hypophosphatemic Rickets and Genotype-PHEX Activity Correlation.
Wu H, Ying H, Zhao W, Sun Y, Wang Y, Chen X, Li G, Yao Y, Xu S, Li T, Fang L, Sun X, Wang N, Xu J, Guan Q, Xia W, Wang L, Gao L, Zhao J, Xu C
The Journal of clinical endocrinology and metabolism 2024 Aug 13;109(9):2242-2255
The Journal of clinical endocrinology and metabolism 2024 Aug 13;109(9):2242-2255
Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage.
Gong K, Xue C, Feng Z, Pan R, Wang M, Chen S, Chen Y, Guan Y, Dai L, Zhang S, Jiang L, Li L, Wang B, Yin Z, Ma L, Iwakiri Y, Tang J, Liao C, Chen H, Duan Y
Nature communications 2024 Aug 10;15(1):6845
Nature communications 2024 Aug 10;15(1):6845
Twin defect-rich Pt ultrathin nanowire nanozymes alleviate inflammatory skin diseases by scavenging reactive oxygen species.
Zhao H, Zhao H, Li M, Tang Y, Xiao X, Cai Y, He F, Huang H, Zhang Y, Li J
Redox biology 2024 Apr;70:103055
Redox biology 2024 Apr;70:103055
Identification of COQ2 as a regulator of proliferation and lipid peroxidation through genome-scale CRISPR-Cas9 screening in myeloma cells.
Li M, Zhang CL, Zhou DS, Chan SH, Liu XQ, Chen SN, Yang ZY, Ju FE, Sang XY, Liu ZX, Zhang QX, Pan YM, Deng SS, Wang XM, Zhong L, Zhang XD, Du X
British journal of haematology 2024 Apr;204(4):1307-1324
British journal of haematology 2024 Apr;204(4):1307-1324
LDL receptor-related protein 5 selectively transports unesterified polyunsaturated fatty acids to intracellular compartments.
Tang W, Luan Y, Yuan Q, Li A, Chen S, Menacherry S, Young L, Wu D
Nature communications 2024 Apr 9;15(1):3068
Nature communications 2024 Apr 9;15(1):3068
Terazosin attenuates abdominal aortic aneurysm formation by downregulating Peg3 expression to inhibit vascular smooth muscle cell apoptosis and senescence.
Wei X, Li Y, Jiang T, Luo P, Dai Y, Wang Q, Xu M, Yan J, Li Y, Gao J, Liu L, Zhang C, Liu Y
European journal of pharmacology 2024 Apr 5;968:176397
European journal of pharmacology 2024 Apr 5;968:176397
Up-regulation of HSP90α in HDM-induced asthma causes pyroptosis of airway epithelial cells by activating the cGAS-STING-ER stress pathway.
Huang H, Qiao Y, Chu L, Ye C, Lin L, Liao H, Meng X, Zou F, Zhao H, Zou M, Cai S, Dong H
International immunopharmacology 2024 Apr 20;131:111917
International immunopharmacology 2024 Apr 20;131:111917
The coumarin component isofraxidin targets the G-protein-coupled receptor S1PR1 to modulate IL-17 signaling and alleviate ulcerative colitis.
Huang Y, Chen X, Liu X, Lin C, Wang Y
International immunopharmacology 2024 Apr 20;131:111814
International immunopharmacology 2024 Apr 20;131:111814
IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline.
Yu L, Wan Q, Liu Q, Fan Y, Zhou Q, Skowronski AA, Wang S, Shao Z, Liao CY, Ding L, Kennedy BK, Zha S, Que J, LeDuc CA, Sun L, Wang L, Qiang L
Cell metabolism 2024 Apr 2;36(4):793-807.e5
Cell metabolism 2024 Apr 2;36(4):793-807.e5
LRRK2 is involved in heat exposure-induced acute lung injury and alveolar type II epithelial cell dysfunction.
Wang Y, Fan W, Zhang G, Zhao L, Li T, Zhang L, Hou T, Hong H, You Z, Sun Q, Li R, Liu C
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123643
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123643
Tyrosine hydroxylase inhibits HCC progression by downregulating TGFβ/Smad signaling.
Liu G, Li M, Zeng Z, Fan Q, Ren X, Wang Z, Sun Y, He Y, Sun L, Deng Y, Liu S, Zhong C, Gao J
European journal of medical research 2024 Apr 12;29(1):228
European journal of medical research 2024 Apr 12;29(1):228
Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation.
Zhou C, Yu T, Zhu R, Lu J, Ouyang X, Zhang Z, Chen Q, Li J, Cui J, Jiang F, Jin KY, Sarapultsev A, Li F, Zhang G, Luo S, Hu D
International journal of biological sciences 2023;19(5):1471-1489
International journal of biological sciences 2023;19(5):1471-1489
Construction and validation of a prognostic signature based on necroptosis-related genes in hepatocellular carcinoma.
Peng YL, Wang LX, Li MY, Liu LP, Li RS
PloS one 2023;18(2):e0279744
PloS one 2023;18(2):e0279744
Sarcoma protein kinase inhibition alleviates liver fibrosis by promoting hepatic stellate cells ferroptosis.
Cheng Z, Zhang X, Chen P, Wang H, Wang K, Shen Y
Open life sciences 2023;18(1):20220781
Open life sciences 2023;18(1):20220781
DNAJC8: a prognostic marker and potential therapeutic target for hepatocellular carcinoma.
Zhang Z, Ju M, Tang Z, He Z, Hua S
Frontiers in immunology 2023;14:1289548
Frontiers in immunology 2023;14:1289548
Unveiling the role of hypoxic macrophage-derived exosomes in driving colorectal cancer progression.
Jiang J, Wang W, Zhu L, Shi B, Chen Y, Xia Y, Feng W, Yao W, Lu A, Zhang H
Frontiers in immunology 2023;14:1260638
Frontiers in immunology 2023;14:1260638
Activation of telomerase activity and telomere elongation of host cells by Theileria annulata infection.
Liu J, Zhao S, Li Z, Zhang Z, Zhao B, Guan G, Yin H, Luo J
Frontiers in microbiology 2023;14:1128433
Frontiers in microbiology 2023;14:1128433
Phenylalanine promotes alveolar macrophage pyroptosis via the activation of CaSR in ARDS.
Tang Y, Yu Y, Li R, Tao Z, Zhang L, Wang X, Qi X, Li Y, Meng T, Qu H, Zhou M, Xu J, Liu J
Frontiers in immunology 2023;14:1114129
Frontiers in immunology 2023;14:1114129
Involvement of p38 MAPK in Leydig cell aging and age-related decline in testosterone.
Luo D, Qi X, Xu X, Yang L, Yu C, Guan Q
Frontiers in endocrinology 2023;14:1088249
Frontiers in endocrinology 2023;14:1088249
Novel flavonoid 1,3,4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway.
Meng HW, Shen ZB, Meng XS, Leng-Wei, Yin ZQ, Wang XR, Zou TF, Liu ZG, Wang TX, Zhang S, Chen YL, Yang XX, Li QS, Duan YJ
Bioorganic chemistry 2023 Sep;138:106654
Bioorganic chemistry 2023 Sep;138:106654
LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11-dependent repression of CDKN2A.
Chen D, Wang J, Li Y, Xu C, Fanzheng M, Zhang P, Liu L
Clinical and translational medicine 2023 Sep;13(9):e1418
Clinical and translational medicine 2023 Sep;13(9):e1418
1,8-cineole ameliorates colon injury by downregulating macrophage M1 polarization via inhibiting the HSP90-NLRP3-SGT1 complex.
Ma S, Yang B, Du Y, Lv Y, Liu J, Shi Y, Huang T, Xu H, Deng L, Chen X
Journal of pharmaceutical analysis 2023 Sep;13(9):984-998
Journal of pharmaceutical analysis 2023 Sep;13(9):984-998
Disulfiram suppresses epithelial-mesenchymal transition (EMT), migration and invasion in cervical cancer through the HSP90A/NDRG1 pathway.
Zheng P, Wu Y, Wang Y, Hu F
Cellular signalling 2023 Sep;109:110771
Cellular signalling 2023 Sep;109:110771
Exploiting immunostimulatory mechanisms of immunogenic cell death to develop membrane-encapsulated nanoparticles as a potent tumor vaccine.
Liu Q, Hu Y, Zheng P, Yang Y, Fu Y, Yang Y, Duan B, Wang M, Li D, Li W, He J, Zheng X, Long Q, Ma Y
Journal of nanobiotechnology 2023 Sep 8;21(1):326
Journal of nanobiotechnology 2023 Sep 8;21(1):326
HSP90/CDC37 inactivation promotes degradation of LKB1 protein to suppress AMPK signaling in bronchial epithelial cells exposed to sulfur mustard analog, 2-chloroethyl ethyl sulfide.
Ye F, Wang X, Liu H, Dong X, Cheng J, Chen M, Dan G, Sai Y, Zou Z
Chemico-biological interactions 2023 Sep 1;382:110643
Chemico-biological interactions 2023 Sep 1;382:110643
USP14 Positively Modulates Head and Neck Squamous Carcinoma Tumorigenesis and Potentiates Heat Shock Pathway through HSF1 Stabilization.
Wang J, Xiang Y, Xie Z, Fan M, Fang S, Wan H, Zhao R, Zeng F, Hua Q
Cancers 2023 Sep 1;15(17)
Cancers 2023 Sep 1;15(17)
Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway.
Zou TF, Liu ZG, Cao PC, Zheng SH, Guo WT, Wang TX, Chen YL, Duan YJ, Li QS, Liao CZ, Xie ZL, Han JH, Yang XX
Acta pharmacologica Sinica 2023 Oct;44(10):2065-2074
Acta pharmacologica Sinica 2023 Oct;44(10):2065-2074
Identification of combinatorial miRNA panels derived from extracellular vesicles as biomarkers for esophageal squamous cell carcinoma.
Wang Y, Li X, Wei X, Li L, Bai H, Yan X, Zhang H, Zhao L, Zhou W, Zhao L
MedComm 2023 Oct;4(5):e377
MedComm 2023 Oct;4(5):e377
Targeting HSP90 with picropodophyllin suppresses gastric cancer tumorigenesis by disrupting the association of HSP90 and AKT.
Li X, Wang G, Zhou X, Zhao H, Chen X, Cui Q, Li M, Gao X, Wei X, Ye L, Li D, Hong P
Phytotherapy research : PTR 2023 Oct;37(10):4740-4754
Phytotherapy research : PTR 2023 Oct;37(10):4740-4754
Targeting TNFAIP2 induces immunogenic cell death and sensitizes glioblastoma multiforme to anti-PD-1 therapy.
Hou C, Shi S, Gao M, Ji J, Ma C, Wang T, Chen T, Liu Y, Zhong J, Zheng Y, Ye J, Ke Y
Journal of neuro-oncology 2023 Oct;165(1):79-90
Journal of neuro-oncology 2023 Oct;165(1):79-90
Smoking Induces a Decline in Semen Quality and the Activation of Stress Response Pathways in Sperm.
Henriques MC, Santiago J, Patrício A, Herdeiro MT, Loureiro S, Fardilha M
Antioxidants (Basel, Switzerland) 2023 Oct 4;12(10)
Antioxidants (Basel, Switzerland) 2023 Oct 4;12(10)
Phosphorylated YBX2 is stabilized to promote glycolysis in brown adipocytes.
Zhao Q, Yu C, Xu X, Jin W, Zhang Z, Huang H, Gao Y, Pan D
iScience 2023 Oct 20;26(10):108091
iScience 2023 Oct 20;26(10):108091
LncRNA MALAT1 Promoted Neuronal Necroptosis in Cerebral Ischemia-reperfusion Mice by Stabilizing HSP90.
Huang S, Hou D, Zhang L, Pei C, Liang J, Li J, Yang G, Yu D
Neurochemical research 2023 Nov;48(11):3457-3471
Neurochemical research 2023 Nov;48(11):3457-3471
6-Methyl flavone inhibits Nogo-B expression and improves high fructose diet-induced liver injury in mice.
Gong K, Zhang Z, Chen SS, Zhu XR, Wang MY, Yang XY, Ding C, Han JH, Li QS, Duan YJ
Acta pharmacologica Sinica 2023 Nov;44(11):2216-2229
Acta pharmacologica Sinica 2023 Nov;44(11):2216-2229
A Dihydroartemisinin-Loaded Nanoreactor Motivates Anti-Cancer Immunotherapy by Synergy-Induced Ferroptosis to Activate Cgas/STING for Reprogramming of Macrophage.
Li LG, Yang XX, Xu HZ, Yu TT, Li QR, Hu J, Peng XC, Han N, Xu X, Chen NN, Chen X, Tang JM, Li TF
Advanced healthcare materials 2023 Nov;12(28):e2301561
Advanced healthcare materials 2023 Nov;12(28):e2301561
FNIP1 abrogation promotes functional revascularization of ischemic skeletal muscle by driving macrophage recruitment.
Sun Z, Yang L, Kiram A, Yang J, Yang Z, Xiao L, Yin Y, Liu J, Mao Y, Zhou D, Yu H, Zhou Z, Xu D, Jia Y, Ding C, Guo Q, Wang H, Li Y, Wang L, Fu T, Hu S, Gan Z
Nature communications 2023 Nov 6;14(1):7136
Nature communications 2023 Nov 6;14(1):7136
HSP90AB1 Is a Host Factor Required for Transmissible Gastroenteritis Virus Infection.
Song D, Zhao Y, Sun Y, Liang Y, Chen R, Wen Y, Wu R, Zhao Q, Du S, Yan Q, Han X, Cao S, Huang X
International journal of molecular sciences 2023 Nov 4;24(21)
International journal of molecular sciences 2023 Nov 4;24(21)
Lactate Conversion by Lactate Dehydrogenase B Is Involved in Beige Adipocyte Differentiation and Thermogenesis in Mice.
Guo B, Shu H, Luo L, Liu X, Ma Y, Zhang J, Liu Z, Zhang Y, Fu L, Song T, Qiao Y, Zhang C
Nutrients 2023 Nov 20;15(22)
Nutrients 2023 Nov 20;15(22)
The HDAC inhibitor HFY-4A improves TUSC2 transcription to induce immunogenic cell death in breast cancer.
Yin Y, Guan X, Li G, Chen C, Duan Y, Yu Z
Toxicology and applied pharmacology 2023 Nov 1;478:116698
Toxicology and applied pharmacology 2023 Nov 1;478:116698
Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles.
Wang Y, Zhang Y, Li Z, Wei S, Chi X, Yan X, Lv H, Zhao L, Zhao L
Proteomics 2023 May;23(9):e2200364
Proteomics 2023 May;23(9):e2200364
Flavonoids derived from licorice suppress LPS-induced acute lung injury in mice by inhibiting the cGAS-STING signaling pathway.
Wen J, Qin S, Li Y, Zhang P, Zhan X, Fang M, Shi C, Mu W, Kan W, Zhao J, Hui S, Hou M, Li H, Xiao X, Xu G, Bai Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113732
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113732
Hsp90 is a potential risk factor for ovarian cancer prognosis: an evidence of a Chinese clinical center.
Duan C, Li K, Pan X, Wei Z, Xiao L
BMC cancer 2023 May 31;23(1):489
BMC cancer 2023 May 31;23(1):489
Poly (ADP-ribose) polymerases 16 triggers pathological cardiac hypertrophy via activating IRE1α-sXBP1-GATA4 pathway.
Su H, Xu J, Su Z, Xiao C, Wang J, Zhong W, Meng C, Yang D, Zhu Y
Cellular and molecular life sciences : CMLS 2023 May 23;80(6):161
Cellular and molecular life sciences : CMLS 2023 May 23;80(6):161
PPARγ Acetylation in Adipocytes Exacerbates BAT Whitening and Worsens Age-Associated Metabolic Dysfunction.
He Y, Zhang R, Yu L, Zahr T, Li X, Kim TW, Qiang L
Cells 2023 May 18;12(10)
Cells 2023 May 18;12(10)
9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3β and HSP90β.
Wang C, Wang T, Hu R, Duan L, Hou Q, Han Y, Dai J, Wang W, Ren S, Liu H, Wang X, Xiao S, Li N, Wang J, Yang Z
Journal of virology 2023 Mar 30;97(3):e0198422
Journal of virology 2023 Mar 30;97(3):e0198422
LncRNA446 Regulates Tight Junctions by Inhibiting the Ubiquitinated Degradation of Alix after Porcine Epidemic Diarrhea Virus Infection.
Qin W, Qi X, Xie Y, Wang H, Wu S, Sun MA, Bao W
Journal of virology 2023 Mar 30;97(3):e0188422
Journal of virology 2023 Mar 30;97(3):e0188422
PPT1 regulation of HSP90α depalmitoylation participates in the pathogenesis of hyperandrogenism.
Xue T, Zhao S, Zhang H, Tang T, Zheng L, Jing J, Ge X, Ma R, Ma J, Ren X, Jueraitetibaike K, Guo Z, Chen L, Yao B
iScience 2023 Mar 17;26(3):106131
iScience 2023 Mar 17;26(3):106131
FGFR2c Upregulation Contributes to Cancer-Associated Fibroblast Program Activation and to Enhanced Autophagy in Actinic Keratosis-Derived Dermal Fibroblasts: A Possible Role in Precancerous Cell/Stromal Cell Crosstalk.
Guttieri L, Raffa S, Salerno G, Bigi R, Persechino F, Visco V, Torrisi MR, Ranieri D, Belleudi F
Biology 2023 Mar 16;12(3)
Biology 2023 Mar 16;12(3)
Dysregulation of striatal dopamine D2/D3 receptor-mediated by hypocretin induces depressive behaviors in rats.
Chen B, Xu J, Chen S, Mou T, Wang Y, Wang H, Zhang Z, Ren F, Wang Z, Jin K, Lu J
Journal of affective disorders 2023 Mar 15;325:256-263
Journal of affective disorders 2023 Mar 15;325:256-263
Near-Infrared Phototheranostic Iron Pyrite Nanocrystals Simultaneously Induce Dual Cell Death Pathways via Enhanced Fenton Reactions in Triple-Negative Breast Cancer.
Zhao C, Liu Z, Chang CC, Chen YC, Zhang Q, Zhang XD, Andreou C, Pang J, Liu ZX, Wang DY, Kircher MF, Yang J
ACS nano 2023 Mar 14;17(5):4261-4278
ACS nano 2023 Mar 14;17(5):4261-4278
Preterm birth alters the feeding-induced activation of Akt signaling in the muscle of neonatal piglets.
Suryawan A, Rudar M, Naberhuis JK, Fiorotto ML, Davis TA
Pediatric research 2023 Jun;93(7):1891-1898
Pediatric research 2023 Jun;93(7):1891-1898
Paeoniflorin protects against cisplatin-induced acute kidney injury through targeting Hsp90AA1-Akt protein-protein interaction.
Zhang MY, Ma LJ, Jiang L, Gao L, Wang X, Huang YB, Qi XM, Wu YG, Liu XQ
Journal of ethnopharmacology 2023 Jun 28;310:116422
Journal of ethnopharmacology 2023 Jun 28;310:116422
Long noncoding RNA HITT coordinates with RGS2 to inhibit PD-L1 translation in T cell immunity.
Lin Q, Liu T, Wang X, Hou G, Xiang Z, Zhang W, Zheng S, Zhao D, Leng Q, Zhang X, Lu M, Guan T, Liu H, Hu Y
The Journal of clinical investigation 2023 Jun 1;133(11)
The Journal of clinical investigation 2023 Jun 1;133(11)
Control of SOX2 protein stability and tumorigenic activity by E3 ligase CHIP in esophageal cancer cells.
Kang L, Zhang H, Wang Y, Chu M, He J, Xue M, Pan L, Zhang Y, Wang Z, Chen Z, Huang Y, Chen Z, Li E, Li J, Xu L, Zhang R, Wong J
Oncogene 2023 Jul;42(30):2315-2328
Oncogene 2023 Jul;42(30):2315-2328
Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis.
Alkhoury C, Henneman NF, Petrenko V, Shibayama Y, Segaloni A, Gadault A, Nemazanyy I, Le Guillou E, Wolide AD, Antoniadou K, Tong X, Tamaru T, Ozawa T, Girard M, Hnia K, Lutter D, Dibner C, Panasyuk G
Nature cell biology 2023 Jul;25(7):975-988
Nature cell biology 2023 Jul;25(7):975-988
Nogo-B inhibition restricts ulcerative colitis via inhibiting p68/miR-155 signaling pathway.
Zheng J, Wang S, Zhang T, Li H, Zhu M, Wei X, Ge Y, Yang X, Zhang S, Xu H, Duan Y, Liu L, Chen Y
International immunopharmacology 2023 Jul;120:110378
International immunopharmacology 2023 Jul;120:110378
Design, synthesis, and SAR study of novel flavone 1,2,4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease.
Shen ZB, Meng HW, Meng XS, Lv ZK, Fang MY, Zhang LL, Lv ZL, Li MS, Liu AK, Han JH, Li QS, Duan YJ
European journal of medicinal chemistry 2023 Jul 5;255:115417
European journal of medicinal chemistry 2023 Jul 5;255:115417
Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance.
He Y, Zheng CC, Yang J, Li SJ, Xu TY, Wei X, Chen WY, Jiang ZL, Xu JJ, Zhang GG, Cheng C, Chen KS, Shi XY, Qin DJ, Liu JB, Li B
Cell discovery 2023 Jul 18;9(1):74
Cell discovery 2023 Jul 18;9(1):74
PPARγ (Peroxisome Proliferator-Activated Receptor γ) Deacetylation Suppresses Aging-Associated Atherosclerosis and Hypercholesterolemia.
Zahr T, Liu L, Chan M, Zhou Q, Cai B, He Y, Aaron N, Accili D, Sun L, Qiang L
Arteriosclerosis, thrombosis, and vascular biology 2023 Jan;43(1):30-44
Arteriosclerosis, thrombosis, and vascular biology 2023 Jan;43(1):30-44
PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms.
He Y, B'nai Taub A, Yu L, Yao Y, Zhang R, Zahr T, Aaron N, LeSauter J, Fan L, Liu L, Tazebay R, Que J, Pajvani U, Wang L, Silver R, Qiang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jan;10(2):e2204190
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jan;10(2):e2204190
Initiation of HIV-1 Gag lattice assembly is required for recognition of the viral genome packaging signal.
Lei X, Gonçalves-Carneiro D, Zang TM, Bieniasz PD
eLife 2023 Jan 23;12
eLife 2023 Jan 23;12
Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis.
Zhou Y, Tang J, Lan J, Zhang Y, Wang H, Chen Q, Kang Y, Sun Y, Feng X, Wu L, Jin H, Chen S, Peng Y
Acta pharmaceutica Sinica. B 2023 Feb;13(2):577-597
Acta pharmaceutica Sinica. B 2023 Feb;13(2):577-597
Chlorin e6-induced photodynamic effect facilitates immunogenic cell death of lung cancer as a result of oxidative endoplasmic reticulum stress and DNA damage.
Yu TT, Hu J, Li QR, Peng XC, Xu HZ, Han N, Li LG, Yang XX, Xu X, Yang ZY, Chen H, Chen X, Wang MF, Li TF
International immunopharmacology 2023 Feb;115:109661
International immunopharmacology 2023 Feb;115:109661
N(6)-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis.
Chen B, Huang Y, He S, Yu P, Wu L, Peng H
Cell chemical biology 2023 Feb 16;30(2):144-158.e10
Cell chemical biology 2023 Feb 16;30(2):144-158.e10
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Hung ST, Linares GR, Chang WH, Eoh Y, Krishnan G, Mendonca S, Hong S, Shi Y, Santana M, Kueth C, Macklin-Isquierdo S, Perry S, Duhaime S, Maios C, Chang J, Perez J, Couto A, Lai J, Li Y, Alworth SV, Hendricks E, Wang Y, Zlokovic BV, Dickman DK, Parker JA, Zarnescu DC, Gao FB, Ichida JK
Cell 2023 Feb 16;186(4):786-802.e28
Cell 2023 Feb 16;186(4):786-802.e28
Exosomal HSP90 induced by remote ischemic preconditioning alleviates myocardial ischemia/reperfusion injury by inhibiting complement activation and inflammation.
Cheng XF, He ST, Zhong GQ, Meng JJ, Wang M, Bi Q, Tu RH
BMC cardiovascular disorders 2023 Feb 1;23(1):58
BMC cardiovascular disorders 2023 Feb 1;23(1):58
Effects of heat shock protein 90 on complement activation in myocardial ischemia/reperfusion injury after pioglitazone preconditioning.
Wang D, He S, Zhong G, Meng J, Bi Q, Tu R
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Dec;32(12):1401-1412
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Dec;32(12):1401-1412
Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes.
Liu Y, Wu K, Fu Y, Li W, Zhao XY
Redox report : communications in free radical research 2023 Dec;28(1):2260646
Redox report : communications in free radical research 2023 Dec;28(1):2260646
The pterostilbene-dihydropyrazole derivative Ptd-1 ameliorates vascular calcification by regulating inflammation.
Wei X, Shen Z, Zhu M, Fang M, Wang S, Zhang T, Zhang B, Yang X, Lv Z, Duan Y, Jiang M, Ma C, Li Q, Chen Y
International immunopharmacology 2023 Dec;125(Pt B):111198
International immunopharmacology 2023 Dec;125(Pt B):111198
Phenylboronic Acid-Modified Near-Infrared Region II Excitation Donor-Acceptor-Donor Molecule for 2-Deoxy-d-Glucose Improved Starvation/Chemo/Photothermal Combination Therapy.
Sun P, Yang W, He J, He L, Chen P, Xu W, Shen Q, Li D, Fan Q
Advanced healthcare materials 2023 Dec;12(30):e2302099
Advanced healthcare materials 2023 Dec;12(30):e2302099
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production.
Wen J, Mu W, Li H, Yan Y, Zhan X, Luo W, Wang Z, Kan W, Zhao J, Hui S, He P, Qin S, Xu Y, Zhang P, Xiao X, Xu G, Bai Z
Molecular medicine (Cambridge, Mass.) 2023 Dec 8;29(1):167
Molecular medicine (Cambridge, Mass.) 2023 Dec 8;29(1):167
Metabolomics and Transcriptomics Analyses of Curcumin Alleviation of Ochratoxin A-Induced Hepatotoxicity.
Hui P, Zheng X, Dong J, Lu F, Xu C, Qu H, Zhu X, Uemoto Y, Lv X, Yin Z, Sun W, Bao W, Wang H
International journal of molecular sciences 2023 Dec 21;25(1)
International journal of molecular sciences 2023 Dec 21;25(1)
Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development.
Shen M, Sirois CL, Guo Y, Li M, Dong Q, Méndez-Albelo NM, Gao Y, Khullar S, Kissel L, Sandoval SO, Wolkoff NE, Huang SX, Xu Z, Bryan JE, Contractor AM, Korabelnikov T, Glass IA, Doherty D, Birth Defects Research Laboratory, Levine JE, Sousa AMM, Chang Q, Bhattacharyya A, Wang D, Werling DM, Zhao X
Neuron 2023 Dec 20;111(24):3988-4005.e11
Neuron 2023 Dec 20;111(24):3988-4005.e11
Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis.
Yang JW, Zou Y, Chen J, Cui C, Song J, Yang MM, Gao J, Hu HQ, Xia LQ, Wang LM, Lv XY, Chen L, Hou XG
Journal of translational medicine 2023 Dec 19;21(1):921
Journal of translational medicine 2023 Dec 19;21(1):921
Bioinformatics-based identification and validation of hub genes associated with aging in patients with coronary artery disease.
Zhang W, Zhao M, Xin L, Qi X, Cao P, Wang J, Li X
Aging 2023 Dec 14;15(24):14830-14844
Aging 2023 Dec 14;15(24):14830-14844
Photothermal-Ionic-Pharmacotherapy of Myocardial Infarction with Enhanced Angiogenesis and Antiapoptosis.
Feng K, Ruan Y, Zhang X, Wu X, Liu Z, Sun X
ACS applied materials & interfaces 2023 Dec 13;15(49):56846-56858
ACS applied materials & interfaces 2023 Dec 13;15(49):56846-56858
JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens Fiber Maturation in Murine Lens Development.
Sun Q, Li J, Ma J, Zheng Y, Ju R, Li X, Ren X, Huang L, Chen R, Tan X, Luo L
Investigative ophthalmology & visual science 2023 Dec 1;64(15):15
Investigative ophthalmology & visual science 2023 Dec 1;64(15):15
ZDHHC17 participates in the pathogenesis of polycystic ovary syndrome by affecting androgen conversion to estrogen in granulosa cells.
Zhao S, Ma R, Jueraitetibaike K, Xu Y, Jing J, Tang T, Shi M, Zhang H, Ge X, Chen L, Yao B, Guo Z
Molecular and cellular endocrinology 2023 Dec 1;578:112076
Molecular and cellular endocrinology 2023 Dec 1;578:112076
lnc-HC ameliorates steatosis by promoting miR-130b-3p biogenesis and the assembly of an RNA-induced silencing complex.
Lan X, Ren J, Du X, Zhang L, Wang S, Yang X, Lu S
Molecular and cellular endocrinology 2023 Dec 1;578:112061
Molecular and cellular endocrinology 2023 Dec 1;578:112061
Mechanism of non-steroidal anti-androgen-induced liver injury: Reactive metabolites of flutamide and bicalutamide activate inflammasomes.
Kato R, Yamada T, Noda T, Tanaka S, Kohda Y, Ijiri Y
Toxicology in vitro : an international journal published in association with BIBRA 2023 Aug;90:105606
Toxicology in vitro : an international journal published in association with BIBRA 2023 Aug;90:105606
Exosomal PPARγ derived from macrophages suppresses LPS-induced peritonitis by negative regulation of CD14/TLR4 axis.
Meng M, Lu M, Feng J, Zhou X, Meng P, Chen L, Zou X, Liu X, Liu L, Gao X, Zhang Y
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Aug;72(8):1567-1581
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Aug;72(8):1567-1581
Transcription factor 21 accelerates vascular calcification in mice by activating the IL-6/STAT3 signaling pathway and the interplay between VSMCs and ECs.
Zhao XK, Zhu MM, Wang SN, Zhang TT, Wei XN, Wang CY, Zheng J, Zhu WY, Jiang MX, Xu SW, Yang XX, Duan YJ, Zhang BC, Han JH, Miao QR, Hu H, Chen YL
Acta pharmacologica Sinica 2023 Aug;44(8):1625-1636
Acta pharmacologica Sinica 2023 Aug;44(8):1625-1636
Maresin-1 protects against pulmonary arterial hypertension by improving mitochondrial homeostasis through ALXR/HSP90α axis.
Liu M, He H, Fan F, Qiu L, Zheng F, Guan Y, Yang G, Chen L
Journal of molecular and cellular cardiology 2023 Aug;181:15-30
Journal of molecular and cellular cardiology 2023 Aug;181:15-30
An injectable, activated neutrophil-derived exosome mimetics/extracellular matrix hybrid hydrogel with antibacterial activity and wound healing promotion effect for diabetic wound therapy.
Yu Y, Jin H, Li L, Zhang X, Zheng C, Gao X, Yang Y, Sun B
Journal of nanobiotechnology 2023 Aug 30;21(1):308
Journal of nanobiotechnology 2023 Aug 30;21(1):308
Immunogenic cell death-based prognostic model for predicting the response to immunotherapy and common therapy in lung adenocarcinoma.
Zhou X, Xu R, Lu T, Wang C, Chang X, Peng B, Shen Z, Yao L, Wang K, Xu C, Shi J, Zhang R, Zhao J, Zhang L
Scientific reports 2023 Aug 16;13(1):13305
Scientific reports 2023 Aug 16;13(1):13305
Effects of diazoxide on streptozotocin induced β cell damage via HSP70/HSP90/TLR4/AMPK signaling pathways.
Kaya ST
Biotechnic & histochemistry : official publication of the Biological Stain Commission 2023 Apr;98(3):210-219
Biotechnic & histochemistry : official publication of the Biological Stain Commission 2023 Apr;98(3):210-219
An artificial intelligence network-guided signature for predicting outcome and immunotherapy response in lung adenocarcinoma patients based on 26 machine learning algorithms.
Zhang N, Zhang H, Liu Z, Dai Z, Wu W, Zhou R, Li S, Wang Z, Liang X, Wen J, Zhang X, Zhang B, Ouyang S, Zhang J, Luo P, Li X, Cheng Q
Cell proliferation 2023 Apr;56(4):e13409
Cell proliferation 2023 Apr;56(4):e13409
RNA-Seq-based transcriptomics analysis during the photodynamic therapy of primary cells in secondary hyperparathyroidism.
Wen Y, Zeng L, Chen Q, Li Y, Fu M, Wang Z, Liu H, Li X, Huang P, Wu W, Zou Q, Yi W
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2023 Apr;22(4):905-917
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2023 Apr;22(4):905-917
Dihydroartemisinin elicits immunogenic death through ferroptosis-triggered ER stress and DNA damage for lung cancer immunotherapy.
Han N, Yang ZY, Xie ZX, Xu HZ, Yu TT, Li QR, Li LG, Peng XC, Yang XX, Hu J, Xu X, Chen X, Wang MF, Li TF
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Apr;112:154682
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Apr;112:154682
Mechanism of HSP90 Inhibitor in the Treatment of DSS-induced Colitis in Mice by Inhibiting MAPK Pathway and Synergistic Effect of Compound Sophorae Decoction.
Yuan Y, Wu H, Shuai B, Liu C, Zhu F, Gao F, Wei C, Fan H
Current pharmaceutical design 2022;28(42):3456-3468
Current pharmaceutical design 2022;28(42):3456-3468
Egr1 confers protection against acetaminophen‑induced hepatotoxicity via transcriptional upregulating of Acaa2.
Lei X, Xu Q, Li C, Niu B, Ming Y, Li J, Tang Y, Li X, Tang J, Wu J, Ju Y, Yao L, Wang B, Miao Q, Zhong W, Zhi Y, Xu L, Li C, Li X, Mao Y
International journal of biological sciences 2022;18(9):3800-3817
International journal of biological sciences 2022;18(9):3800-3817
Patient-Derived Pancreatic Cancer Cells Induce C2C12 Myotube Atrophy by Releasing Hsp70 and Hsp90.
Wu HY, Trevino JG, Fang BL, Riner AN, Vudatha V, Zhang GH, Li YP
Cells 2022 Sep 3;11(17)
Cells 2022 Sep 3;11(17)
Hepatic AMPK signaling dynamic activation in response to REDOX balance are sentinel biomarkers of exercise and antioxidant intervention to improve blood glucose control.
Wu M, Zhao A, Yan X, Gao H, Zhang C, Liu X, Luo Q, Xie F, Liu S, Shi D
eLife 2022 Sep 26;11
eLife 2022 Sep 26;11
AHSA1 Promotes Proliferation and EMT by Regulating ERK/CALD1 Axis in Hepatocellular Carcinoma.
Zhang J, Ren Z, Zheng D, Song Z, Lin J, Luo Y, Zou X, Pan Y, Qi N, Li A, Liu X
Cancers 2022 Sep 22;14(19)
Cancers 2022 Sep 22;14(19)
Daidzein alleviates doxorubicin-induced heart failure via the SIRT3/FOXO3a signaling pathway.
Li H, Zhang M, Wang Y, Gong K, Yan T, Wang D, Meng X, Yang X, Chen Y, Han J, Duan Y, Zhang S
Food & function 2022 Sep 22;13(18):9576-9588
Food & function 2022 Sep 22;13(18):9576-9588
CTCF and cohesin promote focal detachment of DNA from the nuclear lamina.
van Schaik T, Liu NQ, Manzo SG, Peric-Hupkes D, de Wit E, van Steensel B
Genome biology 2022 Sep 1;23(1):185
Genome biology 2022 Sep 1;23(1):185
Neural stem cell‑derived exosomes transfer miR‑124‑3p into cells to inhibit glioma growth by targeting FLOT2.
Qian C, Wang Y, Ji Y, Chen D, Wang C, Zhang G, Wang Y
International journal of oncology 2022 Oct;61(4)
International journal of oncology 2022 Oct;61(4)
c-Myc Sustains Pancreatic Cancer Cell Survival and mutp53 Stability through the Mevalonate Pathway.
Romeo MA, Gilardini Montani MS, Arena A, Benedetti R, D'Orazi G, Cirone M
Biomedicines 2022 Oct 5;10(10)
Biomedicines 2022 Oct 5;10(10)
Analysis of RIOK2 Functions in Mediating the Toxic Effects of Deoxynivalenol in Porcine Intestinal Epithelial Cells.
Gao Z, Xu C, Fan H, Wang H, Wu Z, Wu S, Bao W
International journal of molecular sciences 2022 Oct 22;23(21)
International journal of molecular sciences 2022 Oct 22;23(21)
Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation.
Su H, Meng C, Xu J, Su Z, Xiao C, Yang D
Cell death & disease 2022 Oct 21;13(10):890
Cell death & disease 2022 Oct 21;13(10):890
p38α in the preoptic area inhibits brown adipose tissue thermogenesis.
Wang J, Wu S, Zhan H, Bi W, Xu Y, Liang Y, Ge Y, Peng L, Jin X, Lu K, Zhao J, Gao L, He Z
Obesity (Silver Spring, Md.) 2022 Nov;30(11):2242-2255
Obesity (Silver Spring, Md.) 2022 Nov;30(11):2242-2255
Defective Human SRP Induces Protein Quality Control and Triggers Stress Response.
Tikhonova EB, Gutierrez Guarnizo SA, Kellogg MK, Karamyshev A, Dozmorov IM, Karamysheva ZN, Karamyshev AL
Journal of molecular biology 2022 Nov 30;434(22):167832
Journal of molecular biology 2022 Nov 30;434(22):167832
Activation of the Chemokine Receptor CCR1 and Preferential Recruitment of Gαi Suppress RSV Replication: Implications for Developing Novel Respiratory Syncytial Virus Treatment Strategies.
Li J, Xue L, Wang J, Meng A, Qiao J, Li M, Wang X, Meng L, Ning J, Gao X, Li W, Ma C, Wei L
Journal of virology 2022 Nov 23;96(22):e0130922
Journal of virology 2022 Nov 23;96(22):e0130922
Class 3 phosphoinositide 3-kinase promotes hepatic glucocorticoid receptor stability and transcriptional activity.
Shibayama Y, Alkhoury C, Nemazanyy I, F Henneman N, Cagnard N, Girard M, Atsumi T, Panasyuk G
Acta physiologica (Oxford, England) 2022 May;235(1):e13793
Acta physiologica (Oxford, England) 2022 May;235(1):e13793
Zinc Alleviates Arsenic-Induced Inflammation and Apoptosis in the Head Kidney of Common Carp by Inhibiting Oxidative Stress and Endoplasmic Reticulum Stress.
Xing P, Zhang Y, Chi Q, Li S
Biological trace element research 2022 May;200(5):2380-2390
Biological trace element research 2022 May;200(5):2380-2390
Identification of metastasis-associated exoDEPs in colorectal cancer using label-free proteomics.
Liu X, Li N, Zhang C, Wu X, Zhang S, Dong G, Liu G
Translational oncology 2022 May;19:101389
Translational oncology 2022 May;19:101389
Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells.
Zhang J, Gan Y, Li H, Yin J, He X, Lin L, Xu S, Fang Z, Kim BW, Gao L, Ding L, Zhang E, Ma X, Li J, Li L, Xu Y, Horne D, Xu R, Yu H, Gu Y, Huang W
Nature communications 2022 May 20;13(1):2835
Nature communications 2022 May 20;13(1):2835
In situ injectable hydrogel-loaded drugs induce anti-tumor immune responses in melanoma immunochemotherapy.
Li J, Luo G, Zhang C, Long S, Guo L, Yang G, Wang F, Zhang L, Shi L, Fu Y, Zhang Y
Materials today. Bio 2022 Mar;14:100238
Materials today. Bio 2022 Mar;14:100238
miR-15a and miR-20b sensitize hepatocellular carcinoma cells to sorafenib through repressing CDC37L1 and consequent PPIA downregulation.
Li L, Yu S, Chen J, Quan M, Gao Y, Li Y
Cell death discovery 2022 Jun 27;8(1):297
Cell death discovery 2022 Jun 27;8(1):297
ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress.
Benedetti R, Romeo MA, Arena A, Gilardini Montani MS, Di Renzo L, D'Orazi G, Cirone M
Cell death discovery 2022 Jun 25;8(1):295
Cell death discovery 2022 Jun 25;8(1):295
FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated mitochondrial fusion.
Li S, Han S, Zhang Q, Zhu Y, Zhang H, Wang J, Zhao Y, Zhao J, Su L, Li L, Zhou D, Ye C, Feng XH, Liang T, Zhao B
Nature communications 2022 Jun 17;13(1):3486
Nature communications 2022 Jun 17;13(1):3486
Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice.
Zhang XZ, Wei LL, Zhang XH, Jin HJ, Chen SR
Development (Cambridge, England) 2022 Jun 15;149(12)
Development (Cambridge, England) 2022 Jun 15;149(12)
Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90α, and RXRα.
Zhang L, Yan J, Liu J, Meng C, Liu F, Xia C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul;101:154097
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul;101:154097
The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice.
Zhang XZ, Wei LL, Jin HJ, Zhang XH, Chen SR
Cell reports 2022 Jul 5;40(1):111049
Cell reports 2022 Jul 5;40(1):111049
The impairment of DDR reduces XBP1s, further increasing DNA damage, and triggers autophagy via PERK/eIF2alpha in MM and IRE1alpha/JNK1/2 in PEL cells.
Arena A, Romeo MA, Benedetti R, Gilardini Montani MS, Cirone M
Biochemical and biophysical research communications 2022 Jul 12;613:19-25
Biochemical and biophysical research communications 2022 Jul 12;613:19-25
Dual targeted delivery of statins and nucleic acids by chitosan-based nanoparticles for enhanced antiatherosclerotic efficacy.
Jiang T, Xu L, Zhao M, Kong F, Lu X, Tang C, Yin C
Biomaterials 2022 Jan;280:121324
Biomaterials 2022 Jan;280:121324
AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma.
Gu C, Wang Y, Zhang L, Qiao L, Sun S, Shao M, Tang X, Ding P, Tang C, Cao Y, Zhou Y, Guo M, Wei R, Li N, Xiao Y, Duan J, Yang Y
Journal of experimental & clinical cancer research : CR 2022 Jan 6;41(1):11
Journal of experimental & clinical cancer research : CR 2022 Jan 6;41(1):11
Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy.
van de Veerdonk FL, Renga G, Pariano M, Bellet MM, Servillo G, Fallarino F, De Luca A, Iannitti RG, Piobbico D, Gargaro M, Manni G, D'Onofrio F, Stincardini C, Sforna L, Borghi M, Castelli M, Pieroni S, Oikonomou V, Villella VR, Puccetti M, Giovagnoli S, Galarini R, Barola C, Maiuri L, Della Fazia MA, Cellini B, Talesa VN, Dinarello CA, Costantini C, Romani L
The Journal of clinical investigation 2022 Jan 18;132(2)
The Journal of clinical investigation 2022 Jan 18;132(2)
SLCO4A1-AS1 promotes colorectal tumourigenesis by regulating Cdk2/c-Myc signalling.
Zhang J, Cui K, Huang L, Yang F, Sun S, Bian Z, Wang X, Li C, Yin Y, Huang S, Zhou L, Fei B, Huang Z
Journal of biomedical science 2022 Jan 17;29(1):4
Journal of biomedical science 2022 Jan 17;29(1):4
Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis.
Qin M, Xin Y, Bian Y, Yang X, Xi T, Xiong J
Cells 2022 Jan 13;11(2)
Cells 2022 Jan 13;11(2)
HSP90 inhibitors 17-AAG and VER-82576 inhibit porcine deltacoronavirus replication in vitro.
Zhao Y, Xiao D, Zhang L, Song D, Chen R, Li S, Liao Y, Wen Y, Liu W, Yu E, Wen Y, Wu R, Zhao Q, Du S, Wen X, Cao S, Huang X
Veterinary microbiology 2022 Feb;265:109316
Veterinary microbiology 2022 Feb;265:109316
High-dose VitC plus oncolytic adenoviruses enhance immunogenic tumor cell death and reprogram tumor immune microenvironment.
Ma J, Zhang C, Shi G, Yue D, Shu Y, Hu S, Qi Z, Chen Y, Zhang B, Zhang Y, Huang A, Su C, Zhang Y, Deng H, Cheng P
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Feb 2;30(2):644-661
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Feb 2;30(2):644-661
Novel Loss of Function Variant in BCKDK Causes a Treatable Developmental and Epileptic Encephalopathy.
Boemer F, Josse C, Luis G, Di Valentin E, Thiry J, Cello C, Caberg JH, Dadoumont C, Harvengt J, Lumaka A, Bours V, Debray FG
International journal of molecular sciences 2022 Feb 18;23(4)
International journal of molecular sciences 2022 Feb 18;23(4)
VPA and TSA Interrupt the Interplay between mutp53 and HSP70, Leading to CHK1 and RAD51 Down-Regulation and Sensitizing Pancreatic Cancer Cells to AZD2461 PARP Inhibitor.
Romeo MA, Gilardini Montani MS, Benedetti R, Arena A, D'Orazi G, Cirone M
International journal of molecular sciences 2022 Feb 18;23(4)
International journal of molecular sciences 2022 Feb 18;23(4)
The two-domain architecture of LAMP2A regulates its interaction with Hsc70.
Ikami Y, Terasawa K, Sakamoto K, Ohtake K, Harada H, Watabe T, Yokoyama S, Hara-Yokoyama M
Experimental cell research 2022 Feb 1;411(1):112986
Experimental cell research 2022 Feb 1;411(1):112986
RNA sequence analysis reveals pathways and candidate genes associated with pancreatic acinar cells injury in a mouse pancreatitis model.
Chaoqun H, Rong Y, Yunpeng P, Xiaole Z, Wanli G, Chenyuan S, Dongya H, Yi M, Qiang L
Tissue & cell 2022 Dec;79:101940
Tissue & cell 2022 Dec;79:101940
Inhibition of HSPA8 by rifampicin contributes to ferroptosis via enhancing autophagy.
Zhou J, Tan Y, Hu L, Fu J, Li D, Chen J, Long Y
Liver international : official journal of the International Association for the Study of the Liver 2022 Dec;42(12):2889-2899
Liver international : official journal of the International Association for the Study of the Liver 2022 Dec;42(12):2889-2899
Selective targeting of visceral adiposity by polycation nanomedicine.
Wan Q, Huang B, Li T, Xiao Y, He Y, Du W, Wang BZ, Dakin GF, Rosenbaum M, Goncalves MD, Chen S, Leong KW, Qiang L
Nature nanotechnology 2022 Dec;17(12):1311-1321
Nature nanotechnology 2022 Dec;17(12):1311-1321
A functionalized collagen-I scaffold delivers microRNA 21-loaded exosomes for spinal cord injury repair.
Liu X, Zhang L, Xu Z, Xiong X, Yu Y, Wu H, Qiao H, Zhong J, Zhao Z, Dai J, Suo G
Acta biomaterialia 2022 Dec;154:385-400
Acta biomaterialia 2022 Dec;154:385-400
Acetylation of PPARγ in macrophages promotes visceral fat degeneration in obesity.
Aaron N, Zahr T, He Y, Yu L, Mayfield B, Pajvani UB, Qiang L
Life metabolism 2022 Dec;1(3):258-269
Life metabolism 2022 Dec;1(3):258-269
ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5-12-16L1 complex assembly and autophagy.
Wang D, Yuan T, Liu J, Wen Z, Shen Y, Tang J, Wang Z, Wu X
European journal of immunology 2022 Aug;52(8):1321-1334
European journal of immunology 2022 Aug;52(8):1321-1334
METTL3 preferentially enhances non-m(6)A translation of epigenetic factors and promotes tumourigenesis.
Wei X, Huo Y, Pi J, Gao Y, Rao S, He M, Wei Q, Song P, Chen Y, Lu D, Song W, Liang J, Xu L, Wang H, Hong G, Guo Y, Si Y, Xu J, Wang X, Ma Y, Yu S, Zou D, Jin J, Wang F, Yu J
Nature cell biology 2022 Aug;24(8):1278-1290
Nature cell biology 2022 Aug;24(8):1278-1290
p62/SQSTM1 promotes mitophagy and activates the NRF2-mediated antioxidant and anti-inflammatory response restraining EBV-driven B lymphocyte proliferation.
Gilardini Montani MS, Tarquini G, Santarelli R, Gonnella R, Romeo MA, Benedetti R, Arena A, Faggioni A, Cirone M
Carcinogenesis 2022 Apr 25;43(3):277-287
Carcinogenesis 2022 Apr 25;43(3):277-287
Role of caspase-8 and/or -9 as biomarkers that can distinguish the potential to cause toxic- and immune related-adverse event, for the progress of acetaminophen-induced liver injury.
Noda T, Kato R, Hattori T, Furukawa Y, Ijiri Y, Tanaka K
Life sciences 2022 Apr 1;294:120351
Life sciences 2022 Apr 1;294:120351
A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90.
Ngo V, Brickenden A, Liu H, Yeung C, Choy WY, Duennwald ML
Disease models & mechanisms 2022 Apr 1;15(4)
Disease models & mechanisms 2022 Apr 1;15(4)
Comparative analysis of ChAdOx1 nCoV-19 and Ad26.COV2.S SARS-CoV-2 vector vaccines.
Michalik S, Siegerist F, Palankar R, Franzke K, Schindler M, Reder A, Seifert U, Cammann C, Wesche J, Steil L, Hentschker C, Gesell-Salazar M, Reisinger E, Beer M, Endlich N, Greinacher A, Völker U
Haematologica 2022 Apr 1;107(4):947-957
Haematologica 2022 Apr 1;107(4):947-957
NudC L279P Mutation Destabilizes Filamin A by Inhibiting the Hsp90 Chaperoning Pathway and Suppresses Cell Migration.
Liu M, Xu Z, Zhang C, Yang C, Feng J, Lu Y, Zhang W, Chen W, Xu X, Sun X, Yang M, Liu W, Zhou T, Yang Y
Frontiers in cell and developmental biology 2021;9:671233
Frontiers in cell and developmental biology 2021;9:671233
Plasma HSP90AA1 Predicts the Risk of Breast Cancer Onset and Distant Metastasis.
Liu H, Zhang Z, Huang Y, Wei W, Ning S, Li J, Liang X, Liu K, Zhang L
Frontiers in cell and developmental biology 2021;9:639596
Frontiers in cell and developmental biology 2021;9:639596
The Formation of Melanocyte Apoptotic Bodies in Vitiligo and the Relocation of Vitiligo Autoantigens under Oxidative Stress.
Tian J, Wang Y, Ding M, Zhang Y, Chi J, Wang T, Jiao B, Jian Z, Yi X, Huang Y, Liu L, Li K, Chen J, Wang G, Gao T, Li C, Li Q
Oxidative medicine and cellular longevity 2021;2021:7617839
Oxidative medicine and cellular longevity 2021;2021:7617839
New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB.
Tu RH, Wang DX, Zhong GQ, Meng JJ, Wen H, Jie-Feng, Bi Q, He Y
Open medicine (Warsaw, Poland) 2021;16(1):1552-1563
Open medicine (Warsaw, Poland) 2021;16(1):1552-1563
Sorafenib-Induced Autophagy Promotes Glycolysis by Upregulating the p62/HDAC6/HSP90 Axis in Hepatocellular Carcinoma Cells.
Yan X, Tian R, Sun J, Zhao Y, Liu B, Su J, Li M, Sun W, Xu X
Frontiers in pharmacology 2021;12:788667
Frontiers in pharmacology 2021;12:788667
SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation.
Guan C, Huang X, Yue J, Xiang H, Shaheen S, Jiang Z, Tao Y, Tu J, Liu Z, Yao Y, Yang W, Hou Z, Liu J, Yang XD, Zou Q, Su B, Liu Z, Ni J, Cheng J, Wu X
Theranostics 2021;11(8):3981-3995
Theranostics 2021;11(8):3981-3995
Osteosarcoma Cell-Derived Small Extracellular Vesicles Enhance Osteoclastogenesis and Bone Resorption Through Transferring MicroRNA-19a-3p.
Luo T, Zhou X, Jiang E, Wang L, Ji Y, Shang Z
Frontiers in oncology 2021;11:618662
Frontiers in oncology 2021;11:618662
The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum.
Wang F, Wang Q, Liu B, Mei L, Ma S, Wang S, Wang R, Zhang Y, Niu C, Xiong Z, Zheng Y, Zhang Z, Shi J, Song X
Cell death and differentiation 2021 Sep;28(9):2634-2650
Cell death and differentiation 2021 Sep;28(9):2634-2650
Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism.
Paulo E, Zhang Y, Masand R, Huynh TL, Seo Y, Swaney DL, Soucheray M, Stevenson E, Jimenez-Morales D, Krogan NJ, Wang B
Cell reports 2021 Sep 21;36(12):109742
Cell reports 2021 Sep 21;36(12):109742
Quantitative proteomic analysis of the effects of dietary deprivation of methionine and cystine on A549 xenograft and A549 xenograft-bearing mouse.
Yang H, Zheng H, Pan Y, Zhang W, Yang M, Du H, Yu A, Li P, Chen X, Xie W, Ren K, Zhao Y, Wang T, He X, Zhou Z
Proteomics 2021 Oct;21(20):e2100007
Proteomics 2021 Oct;21(20):e2100007
Mt-Keima detects PINK1-PRKN mitophagy in vivo with greater sensitivity than mito-QC.
Liu YT, Sliter DA, Shammas MK, Huang X, Wang C, Calvelli H, Maric DS, Narendra DP
Autophagy 2021 Nov;17(11):3753-3762
Autophagy 2021 Nov;17(11):3753-3762
Formation and persistence of polyglutamine aggregates in mistranslating cells.
Lant JT, Kiri R, Duennwald ML, O'Donoghue P
Nucleic acids research 2021 Nov 18;49(20):11883-11899
Nucleic acids research 2021 Nov 18;49(20):11883-11899
Hsp90 and its co-chaperone Sti1 control TDP-43 misfolding and toxicity.
Lin LT, Razzaq A, Di Gregorio SE, Hong S, Charles B, Lopes MH, Beraldo F, Prado VF, Prado MAM, Duennwald ML
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21594
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21594
LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy.
Li G, Kryczek I, Nam J, Li X, Li S, Li J, Wei S, Grove S, Vatan L, Zhou J, Du W, Lin H, Wang T, Subramanian C, Moon JJ, Cieslik M, Cohen M, Zou W
Nature cell biology 2021 May;23(5):526-537
Nature cell biology 2021 May;23(5):526-537
A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin(2α)-induced corpus luteum regression.
Li D, Chen J, Guo J, Li L, Cai G, Chen S, Huang J, Yang H, Zhuang Y, Wang F, Wang X
eLife 2021 May 24;10
eLife 2021 May 24;10
Ubc13 Promotes K63-Linked Polyubiquitination of NLRP3 to Activate Inflammasome.
Ni J, Guan C, Liu H, Huang X, Yue J, Xiang H, Jiang Z, Tao Y, Cao W, Liu J, Wang Z, Wang Y, Wu X
Journal of immunology (Baltimore, Md. : 1950) 2021 May 15;206(10):2376-2385
Journal of immunology (Baltimore, Md. : 1950) 2021 May 15;206(10):2376-2385
Inhibition of heat shock protein 90 alleviates cholestatic liver injury by decreasing IL-1β and IL-18 expression.
Tong C, Li J, Lin W, Cen W, Zhang W, Zhu Z, Lu B, Yu J
Experimental and therapeutic medicine 2021 Mar;21(3):241
Experimental and therapeutic medicine 2021 Mar;21(3):241
Single-cell RNA sequencing reveals that targeting HSP90 suppresses PDAC progression by restraining mitochondrial bioenergetics.
Hu LP, Zhou KX, Huo YM, Liu DJ, Li Q, Yang MW, Huang PQ, Xu CJ, Tian GA, Yao LL, Zhang XL, Wang YH, Li J, Zhang ZG, Jiang SH, Xing X, Wang X, Qin WT, Yang Q
Oncogenesis 2021 Mar 3;10(3):22
Oncogenesis 2021 Mar 3;10(3):22
Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis.
Zheng S, Cao P, Yin Z, Wang X, Chen Y, Yu M, Xu B, Liao C, Duan Y, Zhang S, Han J, Yang X
Food & function 2021 Mar 15;12(5):2323-2334
Food & function 2021 Mar 15;12(5):2323-2334
Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice.
Wang D, Yin Z, Ma L, Han L, Chen Y, Pan W, Gong K, Gao Y, Yang X, Chen Y, Han J, Duan Y
Food & function 2021 Jun 7;12(11):4842-4854
Food & function 2021 Jun 7;12(11):4842-4854
Procyanidin B2 Reduces Vascular Calcification through Inactivation of ERK1/2-RUNX2 Pathway.
Liang Y, Chen G, Zhang F, Yang X, Chen Y, Duan Y, Yu M, Zhang S, Han J
Antioxidants (Basel, Switzerland) 2021 Jun 5;10(6)
Antioxidants (Basel, Switzerland) 2021 Jun 5;10(6)
Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells.
Aaron N, Kraakman MJ, Zhou Q, Liu Q, Costa S, Yang J, Liu L, Yu L, Wang L, He Y, Fan L, Hirakawa H, Ding L, Lo J, Wang W, Zhao B, Guo E, Sun L, Rosen CJ, Qiang L
eLife 2021 Jun 22;10
eLife 2021 Jun 22;10
UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model.
Zhang K, Wang A, Zhong K, Qi S, Wei C, Shu X, Tu WY, Xu W, Xia C, Xiao Y, Chen A, Bai L, Zhang J, Luo B, Wang W, Shen C
Neuron 2021 Jun 16;109(12):1949-1962.e6
Neuron 2021 Jun 16;109(12):1949-1962.e6
Identification of exosome miRNAs in bronchial epithelial cells after PM2.5 chronic exposure.
Wang Y, Zhong Y, Sun K, Fan Y, Liao J, Wang G
Ecotoxicology and environmental safety 2021 Jun 1;215:112127
Ecotoxicology and environmental safety 2021 Jun 1;215:112127
LYSMD3: A mammalian pattern recognition receptor for chitin.
He X, Howard BA, Liu Y, Neumann AK, Li L, Menon N, Roach T, Kale SD, Samuels DC, Li H, Kite T, Kita H, Hu TY, Luo M, Jones CN, Okaa UJ, Squillace DL, Klein BS, Lawrence CB
Cell reports 2021 Jul 20;36(3):109392
Cell reports 2021 Jul 20;36(3):109392
WAPL maintains a cohesin loading cycle to preserve cell-type-specific distal gene regulation.
Liu NQ, Maresca M, van den Brand T, Braccioli L, Schijns MMGA, Teunissen H, Bruneau BG, Nora EP, de Wit E
Nature genetics 2021 Jan;53(1):100-109
Nature genetics 2021 Jan;53(1):100-109
The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer.
Qian W, Chen K, Qin T, Xiao Y, Li J, Yue Y, Zhou C, Ma J, Duan W, Lei J, Han L, Li L, Shen X, Wu Z, Ma Q, Wang Z
Journal of experimental & clinical cancer research : CR 2021 Jan 9;40(1):25
Journal of experimental & clinical cancer research : CR 2021 Jan 9;40(1):25
Cytoprotective Effects of Taurine on Heat-Induced Bovine Mammary Epithelial Cells In Vitro.
Bai H, Li T, Yu Y, Zhou N, Kou H, Guo Y, Yang L, Yan P
Cells 2021 Jan 28;10(2)
Cells 2021 Jan 28;10(2)
Echinatin effectively protects against NLRP3 inflammasome-driven diseases by targeting HSP90.
Xu G, Fu S, Zhan X, Wang Z, Zhang P, Shi W, Qin N, Chen Y, Wang C, Niu M, Guo Y, Wang J, Bai Z, Xiao X
JCI insight 2021 Jan 25;6(2)
JCI insight 2021 Jan 25;6(2)
Hydrogen Peroxide-Induced Senescence Reduces the Wound Healing-Promoting Effects of Mesenchymal Stem Cell-Derived Exosomes Partially via miR-146a.
Xu M, Su X, Xiao X, Yu H, Li X, Keating A, Wang S, Zhao RC
Aging and disease 2021 Feb;12(1):102-115
Aging and disease 2021 Feb;12(1):102-115
CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity.
Long L, Wei J, Lim SA, Raynor JL, Shi H, Connelly JP, Wang H, Guy C, Xie B, Chapman NM, Fu G, Wang Y, Huang H, Su W, Saravia J, Risch I, Wang YD, Li Y, Niu M, Dhungana Y, Kc A, Zhou P, Vogel P, Yu J, Pruett-Miller SM, Peng J, Chi H
Nature 2021 Dec;600(7888):308-313
Nature 2021 Dec;600(7888):308-313
MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2α-CYR61 axis.
Yan F, Wang Q, Xia M, Ru Y, Hu W, Yan G, Xiong X, Zhang M, Wang J, Li Q, Zhang B, Wang H, Lin W, Wu G, Li X
Cancer biology & medicine 2021 Dec 22;19(6):818-35
Cancer biology & medicine 2021 Dec 22;19(6):818-35
In Vitro Study of Licorice on IL-1β-Induced Chondrocytes and In Silico Approach for Osteoarthritis.
Ali A, Park Y, Lee J, An HJ, Jin JS, Lee JH, Chang J, Kim DK, Goo B, Park YC, Leem KH, Seong S, Kim W
Pharmaceuticals (Basel, Switzerland) 2021 Dec 20;14(12)
Pharmaceuticals (Basel, Switzerland) 2021 Dec 20;14(12)
Lactoferrin Alleviates Acute Alcoholic Liver Injury by Improving Redox-Stress Response Capacity in Female C57BL/6J Mice.
Li D, Hu Z, He Q, Guo Y, Chong Y, Xu J, Qin L
Journal of agricultural and food chemistry 2021 Dec 15;69(49):14856-14867
Journal of agricultural and food chemistry 2021 Dec 15;69(49):14856-14867
Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues.
Xu Y, Shi T, Cui X, Yan L, Wang Q, Xu X, Zhao Q, Xu X, Tang QQ, Tang H, Pan D
The EMBO journal 2021 Dec 15;40(24):e108069
The EMBO journal 2021 Dec 15;40(24):e108069
PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.
Yan L, Jin W, Zhao Q, Cui X, Shi T, Xu Y, Li F, Jin W, Zhang Z, Zhang Z, Tang QQ, Pan D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Aug;8(16):e2102060
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Aug;8(16):e2102060
Exosomal miR-193b-5p as a regulator of LPS-induced inflammation in dairy cow mammary epithelial cells.
Xu H, Zhang T, Hu X, Xie Y, Wu R, Lian S, Wang J
In vitro cellular & developmental biology. Animal 2021 Aug;57(7):695-703
In vitro cellular & developmental biology. Animal 2021 Aug;57(7):695-703
Augmentation of the heat shock axis during exceptional longevity in Ames dwarf mice.
Trivedi R, Knopf B, Tripathi JK, Rakoczy S, Manocha GD, Brown-Borg H, Jurivich DA
GeroScience 2021 Aug;43(4):1921-1934
GeroScience 2021 Aug;43(4):1921-1934
Amiodarone, Unlike Dronedarone, Activates Inflammasomes via Its Reactive Metabolites: Implications for Amiodarone Adverse Reactions.
Kato R, Ijiri Y, Hayashi T
Chemical research in toxicology 2021 Aug 16;34(8):1860-1865
Chemical research in toxicology 2021 Aug 16;34(8):1860-1865
Lamin-A interacting protein Hsp90 is required for DNA damage repair and chemoresistance of ovarian cancer cells.
Wang Y, Chen Q, Wu D, Chen Q, Gong G, He L, Wu X
Cell death & disease 2021 Aug 12;12(8):786
Cell death & disease 2021 Aug 12;12(8):786
Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effect.
Zhu D, Li S, Chen C, Wang S, Zhu J, Kong L, Luo J
Pharmacological research 2021 Apr;166:105523
Pharmacological research 2021 Apr;166:105523
Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction.
Kato R, Ijiri Y, Hayashi T, Uetrecht J
The Journal of toxicological sciences 2020;45(11):673-680
The Journal of toxicological sciences 2020;45(11):673-680
OSCC Exosomes Regulate miR-210-3p Targeting EFNA3 to Promote Oral Cancer Angiogenesis through the PI3K/AKT Pathway.
Wang H, Wang L, Zhou X, Luo X, Liu K, Jiang E, Chen Y, Shao Z, Shang Z
BioMed research international 2020;2020:2125656
BioMed research international 2020;2020:2125656
17-Allylamino-Demethoxygeldanamycin Ameliorate Microthrombosis Via HSP90/RIP3/NLRP3 Pathway After Subarachnoid Hemorrhage in Rats.
Zuo Y, He T, Liao P, Zhuang K, Yan X, Liu F
Acta neurochirurgica. Supplement 2020;127:69-75
Acta neurochirurgica. Supplement 2020;127:69-75
Influenza A Virus Induces Autophagy by Its Hemagglutinin Binding to Cell Surface Heat Shock Protein 90AA1.
Wang X, Zheng T, Lin L, Zhang Y, Peng X, Yan Y, Lei J, Zhou J, Hu B
Frontiers in microbiology 2020;11:566348
Frontiers in microbiology 2020;11:566348
The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer.
Chou CW, Yang RY, Chan LC, Li CF, Sun L, Lee HH, Lee PC, Sher YP, Ying H, Hung MC
American journal of cancer research 2020;10(8):2621-2634
American journal of cancer research 2020;10(8):2621-2634
Hsp90 inhibitor HSP990 in very low dose upregulates EAAT2 and exerts potent antiepileptic activity.
Sha L, Chen T, Deng Y, Du T, Ma K, Zhu W, Shen Y, Xu Q
Theranostics 2020;10(18):8415-8429
Theranostics 2020;10(18):8415-8429
Multifactorial Attenuation of the Murine Heat Shock Response With Age.
Jurivich DA, Manocha GD, Trivedi R, Lizakowski M, Rakoczy S, Brown-Borg H
The journals of gerontology. Series A, Biological sciences and medical sciences 2020 Sep 25;75(10):1846-1852
The journals of gerontology. Series A, Biological sciences and medical sciences 2020 Sep 25;75(10):1846-1852
Heat shock protein 90 inhibitors suppress pyroptosis in THP-1 cells.
Zhou Z, Li X, Qian Y, Liu C, Huang X, Fu M
The Biochemical journal 2020 Oct 30;477(20):3923-3934
The Biochemical journal 2020 Oct 30;477(20):3923-3934
Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer.
Zhang P, Li C, Li H, Yuan L, Dai H, Peng Z, Deng Z, Chang Z, Cui CP, Zhang L
Cell death and differentiation 2020 Nov;27(11):3177-3195
Cell death and differentiation 2020 Nov;27(11):3177-3195
Inhibitory effect of edible natural compounds with di- and tri-carboxyl moiety on endogenous protease inducing disassembly and degradation of myofibrils from grass carp (Ctenopharyngodon idella).
Ge L, Zhao N, Miao Y, Zhang S, Zhao M, Luo Y, Lai H, Huang Y, Wang Y
Food research international (Ottawa, Ont.) 2020 Nov;137:109457
Food research international (Ottawa, Ont.) 2020 Nov;137:109457
CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury.
Shen Y, Zou Y, Li J, Chen F, Li H, Cai Y
International journal of molecular sciences 2020 Nov 9;21(21)
International journal of molecular sciences 2020 Nov 9;21(21)
Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.
Wang D, Yang X, Chen Y, Gong K, Yu M, Gao Y, Wu X, Hu H, Liao C, Han J, Duan Y
The Journal of biological chemistry 2020 Nov 20;295(47):15870-15882
The Journal of biological chemistry 2020 Nov 20;295(47):15870-15882
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Wang Y, Chen J, Li S, Zhang X, Guo Z, Hu J, Shao X, Song N, Zhao Y, Li H, Yang G, Xu C, Wei C
Redox biology 2020 May;32:101514
Redox biology 2020 May;32:101514
Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity.
Yang B, Xue Q, Guo J, Wang X, Zhang Y, Guo K, Li W, Chen S, Xue T, Qi X, Wang J
Autophagy 2020 May;16(5):842-861
Autophagy 2020 May;16(5):842-861
Light-activated oxygen self-supplied starving therapy in near-infrared (NIR) window and adjuvant hyperthermia-induced tumor ablation with an augmented sensitivity.
Ren J, Zhang L, Zhang J, Zhang W, Cao Y, Xu Z, Cui H, Kang Y, Xue P
Biomaterials 2020 Mar;234:119771
Biomaterials 2020 Mar;234:119771
LongShengZhi capsule inhibits doxorubicin-induced heart failure by anti-oxidative stress.
Xu S, Wang Y, Yu M, Wang D, Liang Y, Chen Y, Liao C, Xie Z, Zhao B, Han J, Duan Y, Yang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109803
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109803
Cytotoxic necrotizing factor 1 promotes bladder cancer angiogenesis through activating RhoC.
Guo Y, Wang J, Zhou K, Lv J, Wang L, Gao S, Keller ET, Zhang ZS, Wang Q, Yao Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):7927-7940
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):7927-7940
The Activation of Heat-Shock Protein After Copper(II) and/or Arsenic(III)-Induced Imbalance of Homeostasis, Inflammatory Response in Chicken Rectum.
Yang X, Zhao H, Wang Y, Liu J, Guo M, Fei D, Mu M, Xing M
Biological trace element research 2020 Jun;195(2):613-623
Biological trace element research 2020 Jun;195(2):613-623
Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.
Liu YT, Huang X, Nguyen D, Shammas MK, Wu BP, Dombi E, Springer DA, Poulton J, Sekine S, Narendra DP
Human molecular genetics 2020 Jun 3;29(9):1547-1567
Human molecular genetics 2020 Jun 3;29(9):1547-1567
Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia.
Di Nardo A, Lenoël I, Winden KD, Rühmkorf A, Modi ME, Barrett L, Ercan-Herbst E, Venugopal P, Behne R, Lopes CAM, Kleiman RJ, Bettencourt-Dias M, Sahin M
Cell reports 2020 Jun 23;31(12):107780
Cell reports 2020 Jun 23;31(12):107780
FBXL6 governs c-MYC to promote hepatocellular carcinoma through ubiquitination and stabilization of HSP90AA1.
Shi W, Feng L, Dong S, Ning Z, Hua Y, Liu L, Chen Z, Meng Z
Cell communication and signaling : CCS 2020 Jun 23;18(1):100
Cell communication and signaling : CCS 2020 Jun 23;18(1):100
SIRT2 suppresses expression of inflammatory factors via Hsp90-glucocorticoid receptor signalling.
Sun K, Wang X, Fang N, Xu A, Lin Y, Zhao X, Nazarali AJ, Ji S
Journal of cellular and molecular medicine 2020 Jul;24(13):7439-7450
Journal of cellular and molecular medicine 2020 Jul;24(13):7439-7450
NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.
Chen W, Wang W, Sun X, Xie S, Xu X, Liu M, Yang C, Li M, Zhang W, Liu W, Wang L, Zhou T, Yang Y
Cell death & disease 2020 Jul 14;11(7):534
Cell death & disease 2020 Jul 14;11(7):534
Aspirin Enhances the Protection of Hsp90 from Heat-Stressed Injury in Cardiac Microvascular Endothelial Cells Through PI3K-Akt and PKM2 Pathways.
Zhang X, Chen B, Wu J, Sha J, Yang B, Zhu J, Sun J, Hartung J, Bao E
Cells 2020 Jan 18;9(1)
Cells 2020 Jan 18;9(1)
Hsp90 Relieves Heat Stress-Induced Damage in Mouse Kidneys: Involvement of Antiapoptotic PKM2-AKT and Autophagic HIF-1α Signaling.
Chen B, Yang B, Zhu J, Wu J, Sha J, Sun J, Bao E, Zhang X
International journal of molecular sciences 2020 Feb 28;21(5)
International journal of molecular sciences 2020 Feb 28;21(5)
Zinc application alleviates the adverse renal effects of arsenic stress in a protein quality control way in common carp.
Wang Y, Zhao H, Nie X, Guo M, Jiang G, Xing M
Environmental research 2020 Dec;191:110063
Environmental research 2020 Dec;191:110063
Dual-specificity phosphatase 29 is induced during neurogenic skeletal muscle atrophy and attenuates glucocorticoid receptor activity in muscle cell culture.
Cooper LM, West RC, Hayes CS, Waddell DS
American journal of physiology. Cell physiology 2020 Aug 1;319(2):C441-C454
American journal of physiology. Cell physiology 2020 Aug 1;319(2):C441-C454
Carnosol inhibits inflammasome activation by directly targeting HSP90 to treat inflammasome-mediated diseases.
Shi W, Xu G, Zhan X, Gao Y, Wang Z, Fu S, Qin N, Hou X, Ai Y, Wang C, He T, Liu H, Chen Y, Liu Y, Wang J, Niu M, Guo Y, Xiao X, Bai Z
Cell death & disease 2020 Apr 20;11(4):252
Cell death & disease 2020 Apr 20;11(4):252
The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions.
Kato R, Ijiri Y, Hayashi T, Uetrecht J
Drug metabolism and disposition: the biological fate of chemicals 2019 Oct;47(10):1093-1096
Drug metabolism and disposition: the biological fate of chemicals 2019 Oct;47(10):1093-1096
The LIV-1-GRPEL1 axis adjusts cell fate during anti-mitotic agent-damaged mitosis.
Chen P, Wang B, Mo Q, Wu P, Fang Y, Tian Y, Jin X, Gao Y, Wu Y, Cao Y, Zhang Y, Xi L, Wang S, Hu J, Ma D, Zhou J, Gao Q, Chen G
EBioMedicine 2019 Nov;49:26-39
EBioMedicine 2019 Nov;49:26-39
First Insights on the Presence of the Unfolded Protein Response in Human Spermatozoa.
Santiago J, Silva JV, Fardilha M
International journal of molecular sciences 2019 Nov 5;20(21)
International journal of molecular sciences 2019 Nov 5;20(21)
Hydroxysteroid sulfotransferase 2B1 affects gastric epithelial function and carcinogenesis induced by a carcinogenic agent.
Hong W, Guo F, Yang M, Xu D, Zhuang Z, Niu B, Bai Q, Li X
Lipids in health and disease 2019 Nov 22;18(1):203
Lipids in health and disease 2019 Nov 22;18(1):203
A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network.
Chen D, Liu X, Xia T, Tekcham DS, Wang W, Chen H, Li T, Lu C, Ning Z, Liu X, Liu J, Qi H, He H, Piao HL
iScience 2019 Jun 28;16:177-191
iScience 2019 Jun 28;16:177-191
Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system.
Rinaldi L, Delle Donne R, Catalanotti B, Torres-Quesada O, Enzler F, Moraca F, Nisticò R, Chiuso F, Piccinin S, Bachmann V, Lindner HH, Garbi C, Scorziello A, Russo NA, Synofzik M, Stelzl U, Annunziato L, Stefan E, Feliciello A
Nature communications 2019 Jun 12;10(1):2572
Nature communications 2019 Jun 12;10(1):2572
Identification and validation of circulating exosomes-based liquid biopsy for esophageal cancer.
Zhao A, Guo L, Xu J, Zheng L, Guo Z, Ling Z, Wang L, Mao W
Cancer medicine 2019 Jul;8(7):3566-3574
Cancer medicine 2019 Jul;8(7):3566-3574
Atlastin-mediated membrane tethering is critical for cargo mobility and exit from the endoplasmic reticulum.
Niu L, Ma T, Yang F, Yan B, Tang X, Yin H, Wu Q, Huang Y, Yao ZP, Wang J, Guo Y, Hu J
Proceedings of the National Academy of Sciences of the United States of America 2019 Jul 9;116(28):14029-14038
Proceedings of the National Academy of Sciences of the United States of America 2019 Jul 9;116(28):14029-14038
Calpain2 but not calpain1 mediated by calpastatin following glutamate-induced regulated necrosis in rat retinal neurons.
Wang S, Huang Y, Yan Y, Zhou H, Wang M, Liao L, Wang Z, Chen D, Ji D, Xia X, Liu F, Huang J, Xiong K
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2019 Jan;221:57-67
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2019 Jan;221:57-67
Chaperone-mediated autophagy is involved in the execution of ferroptosis.
Wu Z, Geng Y, Lu X, Shi Y, Wu G, Zhang M, Shan B, Pan H, Yuan J
Proceedings of the National Academy of Sciences of the United States of America 2019 Feb 19;116(8):2996-3005
Proceedings of the National Academy of Sciences of the United States of America 2019 Feb 19;116(8):2996-3005
Cross-Species Suppression of Hepatoma Cell Growth and Migration by a Schistosoma japonicum MicroRNA.
Lin Y, Zhu S, Hu C, Wang J, Jiang P, Zhu L, Li Z, Wang S, Zhang Y, Xu X, Pan W
Molecular therapy. Nucleic acids 2019 Dec 6;18:400-412
Molecular therapy. Nucleic acids 2019 Dec 6;18:400-412
Vesicular Stomatitis Virus Transcription Is Inhibited by TRIM69 in the Interferon-Induced Antiviral State.
Kueck T, Bloyet LM, Cassella E, Zang T, Schmidt F, Brusic V, Tekes G, Pornillos O, Whelan SPJ, Bieniasz PD
Journal of virology 2019 Dec 15;93(24)
Journal of virology 2019 Dec 15;93(24)
KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly.
Liu Y, Yin W, Wang J, Lei Y, Sun G, Li W, Huang Z, Guo M
Cells 2019 Dec 10;8(12)
Cells 2019 Dec 10;8(12)
SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism.
Wang T, Cao Y, Zheng Q, Tu J, Zhou W, He J, Zhong J, Chen Y, Wang J, Cai R, Zuo Y, Wei B, Fan Q, Yang J, Wu Y, Yi J, Li D, Liu M, Wang C, Zhou A, Li Y, Wu X, Yang W, Chin YE, Chen G, Cheng J
Molecular cell 2019 Aug 22;75(4):823-834.e5
Molecular cell 2019 Aug 22;75(4):823-834.e5
Porcine Reproductive and Respiratory Syndrome Virus nsp11 Antagonizes Type I Interferon Signaling by Targeting IRF9.
Wang D, Chen J, Yu C, Zhu X, Xu S, Fang L, Xiao S
Journal of virology 2019 Aug 1;93(15)
Journal of virology 2019 Aug 1;93(15)
The PERK-EIF2α-ATF4 signaling branch regulates osteoblast differentiation and proliferation by PTH.
Zhang K, Wang M, Li Y, Li C, Tang S, Qu X, Feng N, Wu Y
American journal of physiology. Endocrinology and metabolism 2019 Apr 1;316(4):E590-E604
American journal of physiology. Endocrinology and metabolism 2019 Apr 1;316(4):E590-E604
Visualizing tRNA-dependent mistranslation in human cells.
Lant JT, Berg MD, Sze DHW, Hoffman KS, Akinpelu IC, Turk MA, Heinemann IU, Duennwald ML, Brandl CJ, O'Donoghue P
RNA biology 2018;15(4-5):567-575
RNA biology 2018;15(4-5):567-575
KDM5B demethylates H3K4 to recruit XRCC1 and promote chemoresistance.
Xu W, Zhou B, Zhao X, Zhu L, Xu J, Jiang Z, Chen D, Wei Q, Han M, Feng L, Wang S, Wang X, Zhou J, Jin H
International journal of biological sciences 2018;14(9):1122-1132
International journal of biological sciences 2018;14(9):1122-1132
Inhibition of Heat Shock Protein 90 by 17-AAG Reduces Inflammation via P2X7 Receptor/NLRP3 Inflammasome Pathway and Increases Neurogenesis After Subarachnoid Hemorrhage in Mice.
Zuo Y, Wang J, Liao F, Yan X, Li J, Huang L, Liu F
Frontiers in molecular neuroscience 2018;11:401
Frontiers in molecular neuroscience 2018;11:401
Whole-brain low-intensity pulsed ultrasound therapy markedly improves cognitive dysfunctions in mouse models of dementia - Crucial roles of endothelial nitric oxide synthase.
Eguchi K, Shindo T, Ito K, Ogata T, Kurosawa R, Kagaya Y, Monma Y, Ichijo S, Kasukabe S, Miyata S, Yoshikawa T, Yanai K, Taki H, Kanai H, Osumi N, Shimokawa H
Brain stimulation 2018 Sep-Oct;11(5):959-973
Brain stimulation 2018 Sep-Oct;11(5):959-973
Nogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells.
Gao P, Wang X, Jin Y, Hu W, Duan Y, Shi A, Du Y, Song D, Yang M, Li S, Han B, Zhao G, Zhang H, Fan Z, Miao QR
Breast cancer research : BCR 2018 Sep 12;20(1):112
Breast cancer research : BCR 2018 Sep 12;20(1):112
Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway.
Zhou X, Yan T, Huang C, Xu Z, Wang L, Jiang E, Wang H, Chen Y, Liu K, Shao Z, Shang Z
Journal of experimental & clinical cancer research : CR 2018 Oct 3;37(1):242
Journal of experimental & clinical cancer research : CR 2018 Oct 3;37(1):242
Impacts of simultaneous exposure to arsenic (III) and copper (II) on inflammatory response, immune homeostasis, and heat shock response in chicken thymus.
Liu J, Zhao H, Wang Y, Shao Y, Zhang L, Xing M
International immunopharmacology 2018 Nov;64:60-68
International immunopharmacology 2018 Nov;64:60-68
Non-canonical roles of PFKFB3 in regulation of cell cycle through binding to CDK4.
Jia W, Zhao X, Zhao L, Yan H, Li J, Yang H, Huang G, Liu J
Oncogene 2018 Mar;37(13):1685-1698
Oncogene 2018 Mar;37(13):1685-1698
Arsenic and/or copper caused inflammatory response via activation of inducible nitric oxide synthase pathway and triggered heat shock protein responses in testis tissues of chicken.
Shao Y, Zhao H, Wang Y, Liu J, Li J, Chai H, Xing M
Environmental science and pollution research international 2018 Mar;25(8):7719-7729
Environmental science and pollution research international 2018 Mar;25(8):7719-7729
Intestinal Epithelial Cell-Derived LKB1 Suppresses Colitogenic Microbiota.
Liu X, Lu J, Liu Z, Zhao J, Sun H, Wu N, Liu H, Liu W, Hu Z, Meng G, Shen L, Miller AW, Su B, Li X, Kang Z
Journal of immunology (Baltimore, Md. : 1950) 2018 Mar 1;200(5):1889-1900
Journal of immunology (Baltimore, Md. : 1950) 2018 Mar 1;200(5):1889-1900
Inhibition of HSP90α protects cultured neurons from oxygen-glucose deprivation induced necroptosis by decreasing RIP3 expression.
Wang Z, Guo LM, Wang Y, Zhou HK, Wang SC, Chen D, Huang JF, Xiong K
Journal of cellular physiology 2018 Jun;233(6):4864-4884
Journal of cellular physiology 2018 Jun;233(6):4864-4884
HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma.
Xiao X, Wang W, Li Y, Yang D, Li X, Shen C, Liu Y, Ke X, Guo S, Guo Z
Journal of experimental & clinical cancer research : CR 2018 Aug 28;37(1):201
Journal of experimental & clinical cancer research : CR 2018 Aug 28;37(1):201
A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C. elegans.
Jiang W, Wei Y, Long Y, Owen A, Wang B, Wu X, Luo S, Dang Y, Ma DK
eLife 2018 Apr 17;7
eLife 2018 Apr 17;7
Nogo-B receptor increases the resistance of estrogen receptor positive breast cancer to paclitaxel.
Jin Y, Hu W, Liu T, Rana U, Aguilera-Barrantes I, Kong A, Kumar SN, Wang B, Gao P, Wang X, Duan Y, Shi A, Song D, Yang M, Li S, Han B, Zhao G, Fan Z, Miao QR
Cancer letters 2018 Apr 10;419:233-244
Cancer letters 2018 Apr 10;419:233-244
HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway.
Deng X, Song L, Zhao W, Wei Y, Guo XB
Frontiers in cellular neuroscience 2017;11:420
Frontiers in cellular neuroscience 2017;11:420
Assessment of arsenic trioxide toxicity on cock muscular tissue: alterations of oxidative damage parameters, inflammatory cytokines and heat shock proteins.
Li SW, Guo Y, He Y, Sun X, Zhao HJ, Wang Y, Wang YJ, Xing MW
Ecotoxicology (London, England) 2017 Oct;26(8):1078-1088
Ecotoxicology (London, England) 2017 Oct;26(8):1078-1088
Jolkinolide B induces apoptosis of colorectal carcinoma through ROS-ER stress-Ca(2+)-mitochondria dependent pathway.
Zhang J, Wang Y, Zhou Y, He QY
Oncotarget 2017 Oct 31;8(53):91223-91237
Oncotarget 2017 Oct 31;8(53):91223-91237
LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection.
Liu W, Liu X, Li Y, Zhao J, Liu Z, Hu Z, Wang Y, Yao Y, Miller AW, Su B, Cookson MR, Li X, Kang Z
The Journal of experimental medicine 2017 Oct 2;214(10):3051-3066
The Journal of experimental medicine 2017 Oct 2;214(10):3051-3066
Proteomics and metabolomics analysis of hepatic mitochondrial metabolism in alcohol-preferring and non-preferring rats.
Zeng HL, Yang Q, Du H, Li H, Shen Y, Liu T, Chen X, Kamal GM, Guan Q, Cheng L, Wang J, Xu F
Oncotarget 2017 Nov 24;8(60):102020-102032
Oncotarget 2017 Nov 24;8(60):102020-102032
Copper or/and arsenic induce oxidative stress-cascaded, nuclear factor kappa B-dependent inflammation and immune imbalance, trigging heat shock response in the kidney of chicken.
Wang Y, Zhao H, Shao Y, Liu J, Li J, Xing M
Oncotarget 2017 Nov 17;8(58):98103-98116
Oncotarget 2017 Nov 17;8(58):98103-98116
Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis.
Zhang F, Hao M, Jin H, Yao Z, Lian N, Wu L, Shao J, Chen A, Zheng S
British journal of pharmacology 2017 Mar;174(5):409-423
British journal of pharmacology 2017 Mar;174(5):409-423
Identification of two p53 isoforms from Litopenaeus vannamei and their interaction with NF-κB to induce distinct immune response.
Li H, Wang S, Chen Y, Lǚ K, Yin B, Li S, He J, Li C
Scientific reports 2017 Mar 31;7:45821
Scientific reports 2017 Mar 31;7:45821
Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins.
Li R, Yuan F, Fu W, Zhang L, Zhang N, Wang Y, Ma K, Li X, Wang L, Zhu WG, Zhao Y
The Journal of biological chemistry 2017 Feb 17;292(7):2830-2841
The Journal of biological chemistry 2017 Feb 17;292(7):2830-2841
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
Lian S, Guo J, Wang L, Li W, Wang J, Ji H, Kong F, Xu B, Li S, Yang H
Oncotarget 2017 Dec 29;8(70):115304-115314
Oncotarget 2017 Dec 29;8(70):115304-115314
Synergistic inhibition of tumor growth by combination treatment with drugs against different subpopulations of glioblastoma cells.
Chang CH, Liu WT, Hung HC, Gean CY, Tsai HM, Su CL, Gean PW
BMC cancer 2017 Dec 29;17(1):905
BMC cancer 2017 Dec 29;17(1):905
Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells.
Sun B, Bai Y, Zhang L, Gong L, Qi X, Li H, Wang F, Chi X, Jiang Y, Shao S
PloS one 2016;11(9):e0163622
PloS one 2016;11(9):e0163622
SILAC-based quantitative proteomic analysis of secretome of Marc-145 cells infected with porcine reproductive and respiratory syndrome virus.
Zhao F, Fang L, Wang D, Song T, Wang T, Xin Y, Chen H, Xiao S
Proteomics 2016 Oct;16(20):2678-2687
Proteomics 2016 Oct;16(20):2678-2687
Cytoskeleton-centric protein transportation by exosomes transforms tumor-favorable macrophages.
Chen Z, Yang L, Cui Y, Zhou Y, Yin X, Guo J, Zhang G, Wang T, He QY
Oncotarget 2016 Oct 11;7(41):67387-67402
Oncotarget 2016 Oct 11;7(41):67387-67402
Geldanamycin, an inhibitor of Hsp90, increases paclitaxel-mediated toxicity in ovarian cancer cells through sustained activation of the p38/H2AX axis.
Mo Q, Zhang Y, Jin X, Gao Y, Wu Y, Hao X, Gao Q, Chen P
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Nov;37(11):14745-14755
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Nov;37(11):14745-14755
Exogenous Estradiol Benzoate Induces Spermatogenesis Disorder through Influencing Apoptosis and Oestrogen Receptor Signalling Pathway.
Lei X, Cui K, Liu Q, Zhang H, Li Z, Huang B, Shi D
Reproduction in domestic animals = Zuchthygiene 2016 Feb;51(1):75-84
Reproduction in domestic animals = Zuchthygiene 2016 Feb;51(1):75-84
Bioinformatics analysis of proteomics profiles in senescent human primary proximal tubule epithelial cells.
Lu Y, Wang J, Dapeng C, Wu D, Cai G, Chen X
BMC nephrology 2016 Apr 1;17:39
BMC nephrology 2016 Apr 1;17:39
Changes in gene expression and content of Hsp70 and Hsp90 in striated muscles of mice after 30-day space flight on the biosatellite Bion-M1.
Gritsyna YV, Abdusalamova ZR, Vikhlyantsev IM, Ulanova AD, Shenkman BS, Podlubnaya ZA, Kozlovskaya IB
Doklady. Biochemistry and biophysics 2015;463:199-202
Doklady. Biochemistry and biophysics 2015;463:199-202
Tom70 mediates Sendai virus-induced apoptosis on mitochondria.
Wei B, Cui Y, Huang Y, Liu H, Li L, Li M, Ruan KC, Zhou Q, Wang C
Journal of virology 2015 Apr;89(7):3804-18
Journal of virology 2015 Apr;89(7):3804-18
A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis.
Li D, Xu T, Cao Y, Wang H, Li L, Chen S, Wang X, Shen Z
Proceedings of the National Academy of Sciences of the United States of America 2015 Apr 21;112(16):5017-22
Proceedings of the National Academy of Sciences of the United States of America 2015 Apr 21;112(16):5017-22
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PloS one 2014;9(3):e88543
PloS one 2014;9(3):e88543
Identification of Hsf1 as a novel androgen receptor-regulated gene in mouse Sertoli cells.
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Molecular reproduction and development 2014 Jun;81(6):514-23
Molecular reproduction and development 2014 Jun;81(6):514-23
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Cellular signalling 2014 Apr;26(4):825-32
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Cell research 2010 Sep;20(9):994-1011
Cell research 2010 Sep;20(9):994-1011
Salivary monitoring related to major surgery.
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European journal of clinical investigation 2010 Dec;40(12):1074-80
European journal of clinical investigation 2010 Dec;40(12):1074-80
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 13171-1-AP(HSP90 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using HSP90AA1 antibody 13171-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-HSP90 (IP:13171-1-AP, 3ug; Detection:13171-1-AP 1:500) with K-562 cells lysate 2000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 13171-1-AP(HSP90 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 13171-1-AP(HSP90 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
