BMS110FI

antibody from Invitrogen Antibodies
Targeting: SELE CD62E, ELAM, ELAM1, ESEL
Provider product page for BMS110FI
Flow cytometry

Antibody data

Product number
BMS110FI - Provider product page
Provider
Invitrogen Antibodies
Product name
CD62E (E-selectin) Monoclonal Antibody (CL2), FITC, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: E-Selectin (CL-2) is a mouse monoclonal antibody raised against E-Selectinof human origin. CL2, but not CL37, blocks binding of leukocytes to E-selectin. . Endothelial Leukocyte Adhesion Molecule-1 belongs to the selectin family of adhesion molecules. Together with L-selectin and P-selectin, E-selectin mediates the initial interactions of leukocytes and platelets with endothelial cells. Molecular structure: The extracellular part of all selectins consists of an aminoterminal c-type lectin domain which specifically binds to carbohydrate ligands. This is followed by an EGF-like domain, and, in the case of E-selectin, by 6 short consensus repeats. The transmembrane portion of the molecule is followed by a short cytoplasmic tail. Selectins guide non-activated polymorphonuclear cells to the areas of inflammation in creating first, loose contacts with the endothelial layer. Together with P-selectin, E-selectin is expressed on cytokine-activated endothelial cells, and contributes to the adhesion of still resting leukocytes to the endothelium. This initial binding event is an essential prerequisite for the activation of the immune cells via different inflammatory mediators. In contrast to P-selectin, E-selectin is maximally expressed 2-4 hours after cell activation. Within the next 24-48 hours E-selectin is again eliminated from the cytoplasmic membrane by shedding into the circulation. Applications Tested: Flow Cytometry. Purity: >95%. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser
Reactivity
Human
Host
Mouse
Conjugate
Green dye
Isotype
IgG
Antibody clone number
CL2
Vial size
100 Tests
Concentration
10 µL/Test
Storage
4° C, store in dark
SELE protein structure - BMS110FI shown in red.