orb386070

antibody from Biorbyt
Targeting: FLG
Provider product page for orb386070
Immunohistochemistry

Antibody data

Product number
orb386070 - Provider product page
Provider
Biorbyt
Product name
Filaggrin Antibody
Antibody type
Monoclonal
Description
Filaggrin (FLG) is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple Filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional Filaggrin molecules. Active Filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
FLG/1562
Vial size
20 ug
Storage
Store the Filaggrin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
FLG protein structure - orb386070 shown in red.