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- Antibody Data
- Antigen structure
- References [490]
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- Product number
- 28459-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- Collagen Type II antibody
- Antibody type
- Polyclonal
- Description
- Collagen Type II antibody (Cat. #28459-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human and has been validated for the following applications: IHC,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Chondroitin sulfate alleviates osteoarthritis by upregulating HSPA8 to inhibit chondrocyte ferroptosis.
Ultrasound-responsive piezoelectric hydrogel attenuates oxidative stress-induced nucleus pulposus senescence via AMPK-FOXO1a-mediated mitophagy for intervertebral disc regeneration.
Cinnamyl Alcohol Attenuates Osteoarthritis Progression via PIGR-Mediated Regulation of Chondrocyte Senescence and Cartilage Homeostasis.
Detoxification of T-2 toxin in human chondrocytes due to its hydroxylation by carboxylesterases and arylacetamide deacetylase in the liver.
Huzhang-Xiangbaji compounds enhance the repair of meniscal cartilage by inhibiting ferroptosis and inflammatory microenvironment.
Targeted knockdown of Piezo1 in synovial macrophages attenuates osteoarthritis development.
Biomimetic mineralized xenogenic acellular cartilage matrix promotes the repair of osteochondral defects and the recovery of motor function.
Selective Visualization of Type II Collagen Using Sum-Frequency Generation (SFG).
Targeting CCNB1 Repressed Cartilage Degradation Induced by Inflammation Through NF-κB Pathway in Osteoarthritis.
WDR63 enhances the chondrogenic differentiation and regenerative potential of stem cell from apical papilla by facilitating vimentin function to promote mitochondrial fission.
Development of Intervertebral Disc Organoids through Directed Differentiation of Mesenchymal Stem Cells and Hierarchical 3D Printing.
Natural photosynthetic system for restoring homeostasis of animal organelle interaction network.
Microneedle patches deliver targeted GLP-1RAs-loaded nanoparticles for the treatment of rheumatoid arthritis.
Recycling senescent cell lipids for targeted senotherapy.
ALOX5 knockdown alleviates cartilage damage in osteoarthritis by inhibiting the NF-κB signaling pathway.
Pterostilbene inhibits ferritinophagy-mediated ferroptosis via the NRF2/NCOA4/FTH1 axis and alleviates intervertebral disc degeneration through nanoliposomal delivery.
Long-acting triamcinolone acetonide prodrug microcrystals for sustained intra-articular treatment of osteoarthritis.
Collagen II hydrogel-mediated sustained delivery of lacosamide attenuates cartilage degeneration and pain in osteoarthritis.
A dual-functional hydrogel integrating adhesive and lubricating interfaces for mitochondrial protection-Driven cartilage regeneration.
Microenvironment-educated MSC-EVs loaded injectable smart hydrogel for targeting senescent nucleus pulposus cells and inhibiting ferroptosis against intervertebral disc degeneration.
Chondrocyte-Targeted Nanoparticles Loaded with N-Acetylcysteine Protect Articular Cartilage and Attenuate Osteoarthritis by Inhibiting Ferroptosis via Glutathione Maintenance.
Extracellular vesicles originating from induced pluripotent stem cell-derived chondrocytes facilitate the regeneration of osteoarthritic cartilage.
Mechano-Iontronic Hydrogels Generating Biomimetic Endogenous Bioelectricity for Promoting Cartilage Regeneration.
Pharmacological inhibition of PGK1 by genipin reduces inflammation and oxidative damage in osteoarthritis.
Psoralen promotes SOCS5 to inhibit JAK/STAT3 to alleviate cartilage degeneration in knee osteoarthritis.
GIPC2 regulation of the PKM2/SREBP1 signaling axis controls adipogenic differentiation of mesenchymal stem cells.
An injectable dihydroartemisinin nanocomposite hydrogel for dual-targeting PANoptosis and inflammation to treat osteoarthritis.
MEGF8-mediated GDF8 phosphorylation drives TGF-β hyperactivation in osteoarthritis cartilage degeneration: Mechanism and targeted intervention.
Engineered microalgae-driven gel platform promotes the repairing of senescence-associated intervertebral disc degeneration in rats and goats.
Microenvironment-targeted strontium delivery system reshapes redox homeostasis to halt degenerative cascades in intervertebral discs.
Dopamine-functionalized bioinspired pre-chondrogenic hydrogel for cell-free cartilage regeneration.
Forsythoside B protects cartilage and subchondral bone in osteoarthritis by regulating the Nrf2/NF - κ B signaling pathway.
PTPN22 as a therapeutic target in intervertebral disc degeneration: Modulating mitophagy and pyroptosis through the PI3K/AKT/mTOR axis.
Dental Pulp Stem Cell-Derived Intracellular Vesicles Promote Cartilage Regeneration and Alleviate Pain in Temporomandibular Joint Osteoarthritis.
Injectable microgels loaded with programmable WELNs based on mendelian randomization macroanalysis alleviate osteoarthritis by restoring the circadian rhythm.
Integrating TWAS, chemical-genomic networks, and experimental models: melatonin as a ferroptosis inhibitor in osteoarthritis therapy.
Betamethasone injection at different stages showing different effect on tendon-to-bone healing in a rat rotator cuff tear model.
Remodeling Cellular Uptake via Inducing Clustering of Urokinase Receptors in Hydrogel Microspheres for Alleviating Cartilage Senescence.
Synergistic Effects of Nutritional Formula on Joint Inflammation Through Modulation of Bone Metabolism in Rats.
Integrative analysis of single-cell RNA sequencing, bulk RNA sequencing, and proteomic data identified NOTCH3 as a hub gene contributing to human intervertebral disc fibrosis.
Activated Rac1 promotes chondrocyte apoptosis through the NF-κB pathway in lumbar facet joint osteoarthritis.
Synergistic microenvironment therapy: a dual-function nanogel of supramolecular collagen ll-mimetic matrix and antioxidant MXene for attenuating intervertebral disc degeneration.
HACE1 alleviates intervertebral disc degeneration by inhibiting ferroptosis in nucleus pulposus cells.
The promoting roles of GLP1R and GIPR in stemness maintenance and multiple lineage-specific differentiation of PDLSCs.
KLK8 promotes cartilage degradation and pyroptosis in osteoarthritis by activating the NF-κB and NLRP3 inflammasome pathways.
Injectable microgels carrying engineered biomimetic nanoparticles for osteoarthritis therapy via dual-targeted senescent chondrocyte clearance and endogenous repair promotion.
An engineered triple-network alginate/gelatin hydrogel mediates osteochondral regeneration through temporal regulation of the PI3K-AKT pathway.
Lipid-modulating hyaluronic acid hydrogel promotes chondrogenesis of osteoarthritis progenitor cells for weight-bearing cartilage repair.
Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression.
Targeting adipocyte ESRRA alleviates osteoarthritis via interrupting inter-organelle crosstalk of complement C3-CFD-MAC cascade.
Identification of Autophagy-related Genes of the Osteoarthritis Using Machine Learning Algorithm.
Supramolecular dynamic hydrogels loaded with bevacizumab nanoparticles promote hyaline cartilage regeneration by inhibiting angiogenesis.
HDAC6 exacerbates osteoarthritis by promoting macrophage inflammation-mediated chondrocyte degeneration.
Biphasic Scaffolds Functionalized with Piezoelectric Nanozymes for Osteochondral Defect Regeneration.
Novel lncRNA LncMSTRG.11341.25 Promotes Osteogenic Differentiation of Human Bone Marrow Stem Cells via the miR-939-5p/PAX8 Axis.
Decoding Endoplasmic Reticulum Stress on Chondrocyte Driving Osteoarthritis Development through Integrating Single-Cell and Transcriptomic Profiling.
Microfluidic Synthesis of miR-200c-3p Lipid Nanoparticles: Targeting ZEB2 to Alleviate Chondrocyte Damage in Osteoarthritis.
Acupotomy Ameliorates KOA Related Chondrocyte Premature Senescence Through YAP/FOXD1 Pathway.
Astragaloside IV Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis via the p53/SLC7A11/GPX4 Axis.
Passive hydrotherapy preserves cartilage and muscle integrity in a murine osteoarthritis model: potential role of integrin αV/TGF-β mechanotransduction.
IL-19 suppresses Hippo signaling via modulating YAP1 phosphorylation in osteoarthritis.
Thrombospondin-1 mitigates osteoarthritis progression by inhibiting mechanical stress-induced chondrocyte ferroptosis via the integrin/YAP pathway.
Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress.
Bone remodeling stimulated by Wnt-mediated mitophagy regulated extracellular vesicles in subchondral bone contributes to osteoarthritis development.
Chronic cervical instability in mice and rats: a reproducible model to simulate human intervertebral disc degeneration.
Injectable hydrogel loaded with exosomes from hypoxic umbilical cord-derived mesenchymal stem cells alleviates intervertebral disc degeneration by reversing nucleus pulposus cell senescence.
Low hydrostatic pressure promotes functional homeostasis of nucleus pulposus cells through the TRPV4/CRT/FA complex axis.
A mouse coccygeal intervertebral disc degeneration model with tail-looping constructed using a suturing method.
Selenium nanozyme-crosslinked composite hydrogel for promoting cartilage regeneration in osteoarthritis via an integrated 'outside-in' and 'inside-out' strategy.
Oxidative stress activates YAP/TEAD1/NCOA4 axis to promote ferroptosis of endplate chondrocytes and aggravate intervertebral disc degeneration.
3D-printed advanced scaffold armed with exosomes derived from human skeletal stem cell identified by single-cell RNA sequencing enhances osteochondral regeneration.
Optimal Timing for Initiating Postoperative Mobilization for Healing Enthesis in Onto-Surface Repair.
BRD-K20733377 inhibits ferroptosis and alleviates intervertebral disc degeneration via the STAT3/NFKB1 axis: a multiapproach study.
Duhuo jisheng decoction alleviates osteoarthritis progression by mitigating ferroptosis in chondrocytes via the nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 axis.
Paeoniflorin mitigates iron overload-induced osteoarthritis by suppressing chondrocyte ferroptosis via the p53/SLC7A11/GPX4 pathway.
Amelioration of Post-traumatic Osteoarthritis by Iontophoretic Liposomal Strontium Ranelate Collaborated with Low-Intensity Pulsed Ultrasound in Rats.
A hydrogel-based drug delivery system reduces inflammation and oxidative stress to alleviate intervertebral disc degeneration.
Sodium tanshinone IIA sulfonate alleviates osteoarthritis through targeting SIRT1.
cZFP609 Tethering BiP Alleviates Cartilage Degradation in Osteoarthritis via Remedying Aberrant ER-Mitochondrial Contacts.
Antioxidant functionalized double-net/TA dynamic hydrogel promotes cartilage regeneration through stabilization of chondrocyte phenotype.
Injectable Ca(2+)/Sr(2+)-crosslinked hydrogel with sustained release of LGK-974 for cartilage repair and osteoarthritis prevention via alleviating inflammatory microenvironment.
miR-204-5p Mitigates Disc Degeneration via SKI-Mediated Modulation of Apoptotic Signaling and Matrix Remodeling in Nucleus Pulposus.
Duhuo Jisheng decoction alleviates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the exosome-mediated miR-19b-3p/ACSL4 axis.
Paeonol reduces IL-1β induced apoptosis and degeneration by regulating MAPK pathway in nucleus pulposus cells.
Cytosolic phospholipase A2 as a therapeutic target for degenerative joint diseases.
CORM-3 mitigates osteoarthritis by anti-inflammation and enhancing autophagy via inhibiting MAPK and mTOR pathways.
Circular RNA PVT1 promotes osteoarthritis progression through the miR-550a-3p/CX3CR1 pathway: A mechanistic study.
Antioxidant taurine inhibits chondrocyte ferroptosis through upregulation of OGT/Gpx4 signaling in osteoarthritis induced by anterior cruciate ligament transection.
Cuproptosis in osteoarthritis: Exploring chondrocyte cuproptosis and therapeutic avenues.
An aptamer specifically targeting mCRP ameliorates experimental arthritis.
Therapeutic extracellular vesicles enriched with SNHG5 reprogram autophagy and macrophage polarization in osteoarthritis.
Reg3β promotes chondrocyte proliferation and ECM metabolism during acetabular roof remodeling in a rat model of DDH‑induced residual dysplasia.
Yiqi Xugu HeJi restores cartilage metabolic homeostasis via AKT1-Thr473 activation in osteoarthritis.
Ultrasound-triggered injectable piezoelectric nanocomposite hyaluronic acid-based hydrogel for modulating inflammation and chondrogenesis in osteoarthritis treatment.
The Effect of Platelet-Rich Plasma on Synovial Fibrosis and Cartilage Degeneration in Knee Osteoarthritis.
Establishment and characterization of an inflammatory cartilaginous organoids model for organoid transplantation study.
SHP2-mediated ROS activation induces chondrocyte paraptosis in osteoarthritis and is attenuated by low-intensity pulsed ultrasound.
Injectable visible light cross-linking aldehyde-based methacrylated hyaluronic acid hydrogels enhance cartilage repair via improved BMSC homing and chondrogenic differentiation.
ZC3H13 Promotes NSUN4-Mediated Chondrocyte Mitochondrial Dysfunction and Pyroptosis in Temporomandibular Joint Osteoarthritis.
Therapeutic potential of quercitrin in intervertebral disc degeneration: Targeting pyroptosis and inflammation.
Nicotinamide Adenine Dinucleotide-Loaded Lubricated Hydrogel Microspheres with a Three-Pronged Approach Alleviate Age-Related Osteoarthritis.
Conditional sequential delivery of ginkgetin and rapamycin orchestrates inflammation and autophagy to alleviate intervertebral disc degeneration.
Synergistic therapeutic effect of parecoxib and ilomastat combination in osteoarthritis via inhibition of IL-17/PI3K/AKT/NF-κB activity.
Piezo1 promotes intervertebral disc degeneration through the Ca(2+)/F-actin/Yap signaling axis.
circ_0000389 inhibits intervertebral disc degeneration by targeting the miR-346/KLF7 axis.
Reprogramming Macrophage Phenotype Using a Reactive Oxygen Species-Responsive Liposome Delivery System for Inflammation Microenvironment Remodeling and Osteoarthritis Treatment.
Low intensity pulsed ultrasound alleviates synovial fibrosis in osteoarthritis via the PI3K/AKT pathway.
Selenium deficiency exacerbates cartilage degradation caused by HT-2 toxin via notch signaling pathway activation.
LATS1-modulated ZBTB20 perturbing cartilage matrix homeostasis contributes to early-stage osteoarthritis.
Gastrodin Alleviates Lumbar Intervertebral Disc Degeneration by Suppressing the NF-κB and MAPK Pathways.
Macrophage Changes and High-Throughput Sequencing in Aging Mouse Intervertebral Disks.
GM@mTG-V microspheres promote NP regeneration by reconstructing IVD biomechanics and inflammatory microenvironment.
Xanthohumol bulk-modified polyurethane for tracheal repair: A 'killing two birds with one stone' strategy for tailorable mechanics and durable anti-inflammatory efficacy.
Bi-phasic integrated silk fibroin/polycaprolactone scaffolds for osteochondral regeneration inspired by the native joint tissue and interface.
Enhancing BMSC chondrogenesis with a dynamic viscoelastic hyaluronan hydrogel loaded with kartogenin for cartilage repair.
Senescent cartilage endplate stem cells-derived exosomes induce oxidative stress injury in nucleus pulposus cells and aggravate intervertebral disc degeneration by regulating FOXO3.
Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence.
Role and mechanism of lncRNA ZEB1-AS1 endogenous competition for miR-365a-3p targeting NRF2 in ferroptosis in articular chondrocytes.
OPTN ameliorates chondrocyte apoptosis in temporomandibular joint osteoarthritis by modulating ER-mitochondria Ca(2+) transfer.
Unveiling the mechanisms of mechanical loading-induced knee osteoarthritis through transcriptomics.
RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats' intervertebral disc degeneration.
Modulating systemic anti-inflammatory response mitigates osteoarthritis progression and associated pain after low-dose radiotherapy.
MXene-Based Cartilage-Adhesive Microspheres for Photothermal-Controlled Hydrophobic Drug Release and Mesenchymal Stem Cell Delivery in Osteoarthritis.
Engineering a stem cell-embedded bilayer hydrogel with biomimetic collagen mineralization for tendon-bone interface healing.
Spatiotemporally Programming Microenvironment to Recapitulate Endochondral Ossification via Greenhouse-Inspired Bionic Niche.
Blocking the LRH-1/LCN2 axis by ML-180, an LRH-1 inverse agonist, ameliorates osteoarthritis via inhibiting the MAPK pathway.
Phellodendrine chloride alleviates gouty arthritis through IL-6/STAT3 signaling pathway.
Mechanical Load-Induced Upregulation of Talin2 through Non-Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis.
Dihydromyricetin attenuates intervertebral disc degeneration by inhibiting NLRP3 inflammasome activation via the Keap1/Nrf2/HO-1 pathway.
Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis.
Periplocin targets LRP4 to regulate metabolic homeostasis and anti-inflammation for the treatment of IVDD.
Genetically engineered chondrocyte-mimetic nanoplatform attenuates osteoarthritis by blocking IL-1β and restoring sirtuin-3.
Antler base (Cervus nippon Temminck) peptides modulate the NLRP3 inflammatory pyroptosis and Nrf2/HO-1/NQO1 signaling pathways to ameliorate osteoarthritis: a structural and mechanistic study.
Ameliorating Myocardial Infarction by Concurrent Pyroptosis Suppression and On-Demand Oxygen Production via Functionalized Nanocarrier.
Hydrogel Enhanced Organoid Multidirectional Differentiation via Yap/Tead4 Mechanotransduction for Accelerated Tissue Regeneration.
Blocking calcium-MYC regulatory axis inhibits early dedifferentiation of chondrocytes and contributes to cartilage regeneration.
Garlic-derived Exosomes Alleviate Osteoarthritis Through Inhibiting the MAPK Signaling Pathway.
Cell-free osteoarthritis treatment with dual-engineered chondrocyte-targeted extracellular vesicles derived from mechanical loading primed mesenchymal stem cells.
circ_0075048 silencing regulates LCP1 to improve IL-1β-induced chondrocyte injury by binding with miR-663b.
Enhanced Chondrogenic Potential and Osteoarthritis Treatment Using Cyaonoside A-Induced MSC Delivered via a Hyaluronic Acid-Based Hydrogel System.
Integrated analysis of bioinformatics, mendelian randomization, and experimental validation reveals novel diagnostic and therapeutic targets for osteoarthritis: progesterone as a potential therapeutic agent.
Quercetin Alleviates Hyperglycemic-Generated Endoplasmic Reticulum Stress-Contacted Apoptosis of Rat Nucleus Pulposus Cells.
Osteoarthritis-like changes in rat temporomandibular joint induced by unilateral anterior large overjet treatment.
RICTOR-mediated activation of AKT/mTOR signaling and autophagy inhibition promote osteoarthritis.
Duhuo Jisheng Decoction in reduction of inflammatory response via Transforming growth factor-β/Smad signaling pathway for repairing rabbit articular cartilage Injury: A Randomized Controlled Trial.
Injectable tissue-engineered human cartilage matrix composite fibrin glue for regeneration of articular cartilage defects.
Mechanosensitive lncRNA H19 promotes chondrocyte autophagy, but not pyroptosis, by targeting miR-148a in post-traumatic osteoarthritis.
Betaine enhances SCAPs chondrogenic differentiation and promotes cartilage repair in TMJOA through WDR81.
Blocking the CCL5/CCL7-CCR1 axis regulates macrophage polarization through NF-κB pathway to alleviate the progression of osteoarthritis.
Ferristatin II protects nucleus pulposus against degeneration through inhibiting ferroptosis and activating HIF-1α pathway mediated mitophagy.
Remodeling the Proinflammatory Microenvironment in Osteoarthritis through Interleukin-1 Beta Tailored Exosome Cargo for Inflammatory Regulation and Cartilage Regeneration.
Revolutionizing the treatment of intervertebral disc degeneration: an approach based on molecular typing.
Unbalanced occlusal loading elicited remodeling responses in growing rat temporomandibular joints and Notch1/Hes1 signaling pathway expression.
Matrix stiffness regulates nucleus pulposus cell glycolysis by MRTF-A-dependent mechanotransduction.
PIEZO1-Primary Cilia Axis Mediates Compressive Stress-Induced Growth Plate Degeneration and Ossification in Adolescent Idiopathic Scoliosis.
Sustained Release of Bone Morphogenetic Protein 2/Chitosan-Collagen Scaffold Repairs Rabbit Knee Joint Cartilage Defects.
Integrating superlubricative nanomaterials with precision drug delivery for advanced osteoarthritis therapy.
Bottom-up engineering of the nucleus pulposus using a photocrosslinkable decellularized matrix hydrogel attenuates inflammaging and enhances microtissue-mediated regeneration.
Photothermal-triggered NO-releasing nanofiber membrane mitigates intervertebral disc degeneration via inflammation inhibition and matrix stabilization.
Astragalus Polysaccharide Enhances O-GlcNAcylation Through OGT to Improve Intervertebral Disc Degeneration in Rats.
Theaflavin reduces Achilles tendon heterotopic ossification in mice through the TGF-β/Smad signaling pathway.
Ethyl gallate suppresses ferroptosis and alleviates intervertebral disc degeneration through targeting AKT1.
Targeting neuregulin-1 in cartilage homeostasis restoration: Kaempferol-3-o-rutinoside as a novel treatment for osteoarthritis.
TLR4-IN-C34 attenuates the progression of osteoarthritis through inhibiting inflammation, angiogenesis and pain.
Serum miR-576-5p as a novel diagnostic biomarker and therapeutic target for osteoarthritis via targeting KLF10-mediated chondrocyte dysfunction.
SMARCA5 Cooperates With RSF1 to Promote Pathological Glycolysis and Chondrocyte Dysfunction in Osteoarthritis Through ATPase-Dependent Chromatin Regulation.
RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA.
Mechanism of lidocaine-induced ROS generation triggering DNA double-strand breaks and promoting intervertebral disc cell senescence via the MYC-DUSP1-P53 axis.
Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1.
Schistosoma japonicum-Derived Peptide SJMHE1 Attenuates Osteoarthritis by Promoting Synovial M2 Macrophage Polarisation.
Deliver CEBPE via cartilage targeting Lipid nanoparticle to block CEBPE-LTF-STAT3 positive feedback loop for efficient treatment of cartilage endplate degeneration.
Highly biomimetic three-layer mineralized collagen scaffold featuring a wood-reinforced subchondral bone region for gradient chondrogenic-osteogenic differentiation of bone marrow-derived mesenchymal stem cells.
Zn(2+)-driven metformin conjugated with siRNA attenuates osteoarthritis progression by inhibiting NF-κB signaling and activating autophagy.
Tissue-specific composite hydrogel-loaded BMSCs inhibit apoptosis and promote meniscal repair.
Cold exposure promotes the progression of osteoarthritis through downregulating APOE in cartilage.
USP5-Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation.
β-Mangostin Attenuates TET2-Mediated DNA Demethylation of Prkcg in the Prevention of Intervertebral Disc Degeneration.
DNA Origami-Based CD44-Targeted Therapy Silences Stat3 Enhances Cartilage Regeneration and Alleviates Osteoarthritis Progression.
Matrix Stiffening-Induced SLIT3 Activation in Chondrocytes Drives Cartilage Degradation and Angiogenesis in Temporomandibular Joint Osteoarthritis.
A multifaceted strategy for intra- and extracellular nucleic acid regulation to alleviate intervertebral disc degeneration.
β-Sitosterol preconditioning enhances the resistance of BMSCs and chondrocyte to oxidative stress and promotes cartilage repair in osteoarthritis.
HIF-1α regulates the proliferation and differentiation of mouse cranial base sphenoid-occipital synchondrosis chondrocytes via PI3K/Akt signaling.
The miR-6779/XIAP axis alleviates IL-1β-induced chondrocyte senescence and extracellular matrix loss in osteoarthritis.
Synergizing adaptive immunity and regenerative signals to enhance osteochondral defects repair.
sLithospermic acid etched ZIF-8 nanoparticles delays osteoarthritis progression by inhibiting inflammatory signaling pathways and rescuing mitochondrial damage.
tsRNA-12391-Modified Adipose Mesenchymal Stem Cell-Derived Exosomes Mitigate Cartilage Degeneration in Osteoarthritis by Enhancing Mitophagy.
Inflammation-modulating elastic decellularized extracellular matrix scaffold promotes meniscus regeneration.
Cerium Dioxide Nanoparticles-Based Inspector Enhances Mitochondrial Quality Control to Maintain Chondrocyte Homeostasis in Osteoarthritis Therapy.
Palmatine activation of TFEB enhances autophagy and alleviates endoplasmic reticulum stress in intervertebral disc degeneration.
3-D Sustained-Release Culture Carrier Alleviates Rat Intervertebral Disc Degeneration by Targeting STING in Transplanted Skeletal Stem Cells.
Enhanced Ear Cartilage Regeneration with Dual-Network LT-GelMA/F127DA Hydrogel Featuring Nanomicelle Integration.
Fullerol Initiates Stem Cell-Nanomaterials Interactions for Enhanced Tissue Regeneration via Clathrin-Mediated Endocytosis and Nuclear Factor Erythroid 2-Related Factor 2 Signaling.
Microneedle delivery of CAR-M-like engineered macrophages alleviates intervertebral disc degeneration through enhanced efferocytosis capacity.
Quercetin-primed MSC exosomes synergistically attenuate osteoarthritis progression.
Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes.
Platelet-rich plasma ameliorates cartilage degradation in rat models of osteoarthritis via the OPG/RANKL/RANK system.
Hyaluronic Acid-Based Microparticles with Lubrication and Anti-Inflammation for Alleviating Temporomandibular Joint Osteoarthritis.
The role and underlying mechanism of dental pulp stem cell-derived exosomal miR-31 in the treatment of osteoarthritis by targeting mTOR to enhance chondrocyte autophagy levels.
Mume Fructus reduces interleukin-1 beta-induced cartilage degradation via MAPK downregulation in rat articular chondrocytes.
Protective effects of ectoine on articular chondrocytes and cartilage in rats for treating osteoarthritis.
The Therapeutic Potential of Pristimerin in Osteoarthritis: Mechanistic Insights from in vitro and in vivo Studies.
Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Radix Rehmanniae Praeparata - Angelica Sinensis - Radix Achyranthis Bidentatae in Treating Knee Osteoarthritis.
"Dictionary of immune responses" reveals the critical role of monocytes and the core target IRF7 in intervertebral disc degeneration.
Role of integrin β1 and tenascin C mediate TGF-SMAD2/3 signaling in chondrogenic differentiation of BMSCs induced by type I collagen hydrogel.
Melatonin Alleviates Osteoarthritis by Regulating NADPH Oxidase 4-Induced Ferroptosis and Mitigating Mitochondrial Dysfunction.
Memantine attenuates the development of osteoarthritis by blocking NMDA receptor mediated calcium overload and chondrocyte senescence.
Injectable Inflammation-Responsive Hydrogels for Microenvironmental Regulation of Intervertebral Disc Degeneration.
Suppression of YAP Ameliorates Cartilage Degeneration in Ankle Osteoarthritis via Modulation of the Wnt/β-Catenin Signaling Pathway.
Isoquercetin Ameliorates Osteoarthritis via Nrf2/NF-κB Axis: An In Vitro and In Vivo Study.
10-hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence in male mice preclinically.
Deferoxamine alleviates chondrocyte senescence and osteoarthritis progression by maintaining iron homeostasis.
Omega-3 fatty acids protect cartilage from acute injurie by reducing the mechanical sensitivity of chondrocytes.
Macrophage membrane-camouflaged biomimetic nanoparticles for rheumatoid arthritis treatment via modulating macrophage polarization.
Lubricin-Inspired Nanozymes Reconstruct Cartilage Lubrication System with an "In-Out" Strategy.
Ellagic acid improves osteoarthritis by inhibiting PGE2 production in M1 macrophages via targeting PTGS2.
Sequential Targeted Enzyme-Instructed Self-Assembly Supramolecular Nanofibers to Attenuate Intervertebral Disc Degeneration.
Enhancing long-segmental tracheal restoration: A self-repairing hydrogel loaded with chondrocytokines for sutureless anastomosis and cartilage regeneration.
Angelica sinensis polysaccharide facilitates chondrogenic differentiation of adipose-derived stem cells via MDK-PI3K/AKT signaling cascade.
ROS-Responsive Injectable Hydrogel Loaded with SLC7A11-modRNA Inhibits Ferroptosis and Mitigates Intervertebral Disc Degeneration in Rats.
IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2.
Bioenergetic-active exosomes for cartilage regeneration and homeostasis maintenance.
Cyclic negative pressure promotes chondrocyte growth: Association of IGF-2 with EGR-1.
TDP-43 ameliorates aging-related cartilage degradation through preventing chondrocyte senescence.
KLF2 Inhibits Ferroptosis and Improves Mitochondrial Dysfunction in Chondrocyte Through SIRT1/GPX4 Signaling to Improve Osteoarthritis.
An anti-senescence hydrogel with pH-responsive drug release for mitigating intervertebral disc degeneration and low back pain.
Polyphenol-modified biomimetic bioadhesives for the therapy of annulus fibrosus defect and nucleus pulposus degeneration after discectomy.
Anti-Stress and Anti-ROS Effects of MnOx-Functionalized Thermosensitive Nanohydrogel Protect BMSCs for Intervertebral Disc Degeneration Repair.
RIP1 inhibition reduces chondrocyte apoptosis through downregulating nuclear factor-kappa B signaling in a mouse osteoarthritis model.
Procyanidin C1 ameliorates acidic pH stress induced nucleus pulposus degeneration through SIRT3/FOXO3-mediated mitochondrial dynamics.
Zfp260 choreographs the early stage osteo-lineage commitment of skeletal stem cells.
Systematic analysis of lysine lactylation in nucleus pulposus cells.
HIF-2α/TFR1 mediated iron homeostasis disruption aggravates cartilage endplate degeneration through ferroptotic damage and mtDNA release: A new mechanism of intervertebral disc degeneration.
Exosomes from umbilical cord mesenchymal stem cells ameliorate intervertebral disc degeneration via repairing mitochondrial dysfunction.
Development of alginate-collagen interpenetrating network for osteoarthritic cartilage by in situ softening.
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.
Effect of umbilical cord blood-mononuclear cells on knee osteoarthritis in rabbits.
Genkwanin alleviates intervertebral disc degeneration via regulating ITGA2/PI3K/AKT pathway and inhibiting apoptosis and senescence.
Chondroprotective effects of Apolipoprotein D in knee osteoarthritis mice through the PI3K/AKT/mTOR signaling pathway.
Targeting the HSP47-collagen axis inhibits brain metastasis by reversing M2 microglial polarization and restoring anti-tumor immunity.
Engineered Exosomes with ATF5-Modified mRNA Loaded in Injectable Thermogels Alleviate Osteoarthritis by Targeting the Mitochondrial Unfolded Protein Response.
Inhibition of SAT1 alleviates chondrocyte inflammation and ferroptosis by repressing ALOX15 expression and activating the Nrf2 pathway.
Peptide-Based Hydrogel Scaffold Facilitates Articular Cartilage Damage Repair.
SIRT3 alleviates high glucose-induced chondrocyte injury through the promotion of autophagy and suppression of apoptosis in osteoarthritis progression.
Gentiopicroside ameliorates the lipopolysaccharide-induced inflammatory response and hypertrophy in chondrocytes.
Circular RNA CircFOXO3 Functions as a Competitive Endogenous RNA for Acid-Sensing Ion Channel Subunit 1 Mediating Oxeiptosis in Nucleus Pulposus.
TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis.
Low-intensity pulsed ultrasound delays the progression of osteoarthritis by regulating the YAP-RIPK1-NF-κB axis and influencing autophagy.
Atractylenolide-III attenuates osteoarthritis by repolarizing macrophages through inactivating TLR4/NF-κB signaling.
Moderate mechanical stress suppresses chondrocyte ferroptosis in osteoarthritis by regulating NF-κB p65/GPX4 signaling pathway.
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy.
Astaxanthin reduces inflammation and promotes a chondrogenic phenotype by upregulating SIRT1 in osteoarthritis.
A natural hydrogel complex improves intervertebral disc degeneration by correcting fatty acid metabolism and inhibiting nucleus pulposus cell pyroptosis.
A multifunctional nanogel encapsulating layered double hydroxide for enhanced osteoarthritis treatment via protection of chondrocytes and ECM.
Botulinum toxin A attenuates osteoarthritis development via inhibiting chondrocyte ferroptosis through SLC7Al1/GPX4 axis.
A Novel Role for Protein Tyrosine Phosphatase 1B in Alleviating Chondrocyte Senescence.
α-Ketoglutarate alleviates osteoarthritis by inhibiting ferroptosis via the ETV4/SLC7A11/GPX4 signaling pathway.
Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis.
TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes.
MMP13-targeted siRNA-loaded micelles for diagnosis and treatment of posttraumatic osteoarthritis.
Activation of Notch Signaling Pathway is involved in Extracellular Matrix Degradation in human induced pluripotent stem cells chondrocytes induced by HT-2 toxin.
Acetyl-11-keto-β-boswellic acid restrains the progression of synovitis in osteoarthritis via the Nrf2/HO-1 pathway.
The regulatory mechanism of cyclic GMP-AMP synthase on inflammatory senescence of nucleus pulposus cell.
IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte damage in osteoarthritis.
The Combined Intraosseous Administration of Orthobiologics Outperformed Isolated Intra-articular Injections in Alleviating Pain and Cartilage Degeneration in a Rat Model of MIA-Induced Knee Osteoarthritis.
Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway.
Exercise-induced modulation of myokine irisin on muscle-bone unit in the rat model of post-traumatic osteoarthritis.
Carveol alleviates osteoarthritis progression by acting on synovial macrophage polarization transformation: An in vitro and in vivo study.
COL3A1 is a potential diagnostic biomarker for synovial chondromatosis and affects the cell cycle and migration of chondrocytes.
Calycosin ameliorates osteoarthritis by regulating the imbalance between chondrocyte synthesis and catabolism.
The CREB1 inhibitor 666-15 maintains cartilage homeostasis and mitigates osteoarthritis progression.
Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
FOXO3-Activated HOTTIP Sequesters miR-615-3p away from COL2A1 to Mitigate Intervertebral Disc Degeneration.
Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6.
P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability.
SYNJ2BP ameliorates intervertebral disc degeneration by facilitating mitochondria-associated endoplasmic reticulum membrane formation and mitochondrial Zn(2+) homeostasis.
PUD@HA/PEEK Scaffold Induces Subchondral Bone Regeneration to Repair Osteochondral Defect in Rabbits.
CARMA3 Drives NF-κB Activation and Promotes Intervertebral Disc Degeneration: Involvement of CARMA3-BCL10-MALT1 Signalosome.
Macrophage polarization and macrophage-related factor expression in hypertrophy of the ligamentum flavum.
Enhanced therapeutic potential of a self-healing hyaluronic acid hydrogel for early intervention in osteoarthritis.
Injectable decellularized Wharton's jelly hydrogel containing CD56(+) umbilical cord mesenchymal stem cell-derived exosomes for meniscus tear healing and cartilage protection.
The active ingredient of Evodia rutaecarpa reduces inflammation in knee osteoarthritis rats through blocking calcium influx and NF-κB pathway.
Controlled Release of Ceria and Ferric Oxide Nanoparticles via Collagen Hydrogel for Enhanced Osteoarthritis Therapy.
Ultra-Long-Term Anti-Inflammatory Polyphenol Capsule to Remodel the Microenvironment for Accelerating Osteoarthritis Healing by Single Dosage.
Ginkgolide A enhances FoxO1 expression and reduces endoplasmic reticulum stress to mitigate osteoarthritis in mice.
Nuciferine ameliorates osteoarthritis: An in vitro and in vivo study.
Kongensin A targeting PI3K attenuates inflammation-induced osteoarthritis by modulating macrophage polarization and alleviating inflammatory signaling.
True-bone-ceramics / type I collagen scaffolds for repairing osteochondral defect.
Guilu Erxian glue reduces endoplasmic reticulum stress-mediated apoptosis and restores the balance of extracellular matrix synthesis and degradation in chondrocytes by inhibiting the ATF6/GRP78/CHOP signaling pathway.
LCCP exposure leads to skin cell senescence damage by triggering oxidative stress mediated by mitochondrial Ca(2+) overload.
Enhancing GFPT1 expression with glutamine protects chondrocytes in osteoarthritis.
Taurine rescues intervertebral disc degeneration by activating mitophagy through the PINK1/Parkin pathway.
Targeted lipid nanoparticles distributed in hydrogel treat osteoarthritis by modulating cholesterol metabolism and promoting endogenous cartilage regeneration.
Potential Effects of Indomethacin on Alleviating Osteoarthritis Progression in Vitro.
Supraspinatus Tendon Reconstruction Versus the Bridging Technique in a Rat Model: Histological, Biomechanical, and Functional Outcomes.
Diatomite-incorporated hierarchical scaffolds for osteochondral regeneration.
Excessive mechanical loading promotes osteoarthritis development by upregulating Rcn2.
Degrasyn alleviates osteoarthritis by blocking macrophagic pyroptosis via suppressing NLRP3/GSDMD signaling pathway and protecting chondrocytes.
Zwitterion-Lubricated Hydrogel Microspheres Encapsulated with Metformin Ameliorate Age-Associated Osteoarthritis.
Pulsed electromagnetic fields potentiate bone marrow mesenchymal stem cell chondrogenesis by regulating the Wnt/β-catenin signaling pathway.
Mulberroside A mitigates intervertebral disc degeneration by inhibiting MAPK and modulating Ppar-γ/NF-κB pathways.
A(2A)R regulate inflammation through PKA/NF-κB signaling pathways in intervertebral disc degeneration.
Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage.
Zhiqiao Gancao decoction regulated JAK2/STAT3/ macrophage M1 polarization to ameliorate intervertebral disc degeneration.
Inhibiting DNA methyltransferase DNMT3B confers protection against ferroptosis in nucleus pulposus and ameliorates intervertebral disc degeneration via upregulating SLC40A1.
Injectable Microgels with Hybrid Exosomes of Chondrocyte-Targeted FGF18 Gene-Editing and Self-Renewable Lubrication for Osteoarthritis Therapy.
Injectable pathological microenvironment-responsive anti-inflammatory hydrogels for ameliorating intervertebral disc degeneration.
Baicalin Maintains Articular Cartilage Homeostasis and Alleviates Osteoarthritis by Activating FOXO1.
Injectable silk fibroin peptide nanofiber hydrogel composite scaffolds for cartilage regeneration.
The NLRX1-SLC39A7 complex orchestrates mitochondrial dynamics and mitophagy to rejuvenate intervertebral disc by modulating mitochondrial Zn(2+) trafficking.
Spermidine ameliorates osteoarthritis via altering macrophage polarization.
Tenascin-C promotes endochondral ossification and fracture healing through Hedgehog and Hippo signaling.
Urolithin B reduces cartilage degeneration and alleviates osteoarthritis by inhibiting inflammation.
miR-1 Inhibits the Ferroptosis of Chondrocyte by Targeting CX43 and Alleviates Osteoarthritis Progression.
Pioglitazone-Loaded Cartilage-Targeted Nanomicelles (Pio@C-HA-DOs) for Osteoarthritis Treatment.
The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies.
Therapeutic Effect of Acupotomy at Sanheyang for Cartilage Collagen Damage in Moderate Knee Osteoarthritis: A Rabbit Model.
Digoxin protects against intervertebral disc degeneration via TNF/NF-κB and LRP4 signaling.
Microtubule stabilization promotes the synthesis of type 2 collagen in nucleus pulposus cell by activating hippo-yap pathway.
Overexpression of fibroblast growth factor receptor 2 in bone marrow mesenchymal stem cells enhances osteogenesis and promotes critical cranial bone defect regeneration.
Quiescence preconditioned nucleus pulposus stem cells alleviate intervertebral disc degeneration by enhancing cell survival via adaptive metabolism pattern in rats.
Identification of EGFR as an essential regulator in chondrocytes ferroptosis of osteoarthritis using bioinformatics, in vivo, and in vitro study.
Donor-Matched Peripheral Blood-Derived Mesenchymal Stem Cells Combined With Platelet-Rich Plasma Synergistically Ameliorate Surgery-Induced Osteoarthritis in Rabbits: An In Vitro and In Vivo Study.
Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages.
Function and regulation of nuclear factor 1 X-type on chondrocyte proliferation and differentiation.
Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis.
TGF-β1 Triggers Salivary Hypofunction via Attenuating Protein Secretion and AQP5 Expression in Human Submandibular Gland Cells.
Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF‑κB and MAPK signalling transduction through integrin αVβ3.
An in vitro and in vivo study: Valencene protects cartilage and alleviates the progression of osteoarthritis by anti-oxidative stress and anti-inflammatory effects.
Exploring the chondroprotective effect of Chaenomeles speciosa on Glucose-6-Phosphate Isomerase model mice using an integrated approach of network pharmacology and experimental validation.
Focused low-intensity pulsed ultrasound alleviates osteoarthritis via restoring impaired FUNDC1-mediated mitophagy.
Pentraxin 3 deficiency ameliorates the severity of osteoarthritis and alleviates inflammation.
Dapagliflozin suppress endoplasmic reticulum stress mediated apoptosis of chondrocytes by activating Sirt1.
α-Ketoglutaric acid ameliorates intervertebral disk degeneration by blocking the IL-6/JAK2/STAT3 pathway.
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death.
Activation of the Nrf-2 pathway by pinocembrin safeguards vertebral endplate chondrocytes against apoptosis and degeneration caused by oxidative stress.
BSHXF-medicated serum combined with ADSCs regulates the TGF-β1/Smad pathway to repair oxidatively damaged NPCs and its component analysis.
Sophisticated Magneto-Mechanical Actuation Promotes In Situ Stem Cell Assembly and Chondrogenesis for Treating Osteoarthritis.
A20 ameliorates disc degeneration by suppressing mTOR/BNIP3 axis-mediated mitophagy.
Integrin expression and extracellular matrix adhesion of septoclasts, pericytes, and endothelial cells at the chondro-osseous junction and the metaphysis of the proximal tibia in young mice.
The Bcr-Abl inhibitor DCC-2036 inhibits necroptosis and ameliorates osteoarthritis by targeting RIPK1 and RIPK3 kinases.
BuShen JianGu Fang alleviates cartilage degeneration via regulating multiple genes and signaling pathways to activate NF-κB/Sox9 axis.
An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment.
Polydopamine-Pd nanozymes as potent ROS scavengers in combination with near-infrared irradiation for osteoarthritis treatment.
Preparation of Melatonin-Loaded Nanoparticles with Targeting and Sustained Release Function and Their Application in Osteoarthritis.
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
METTL3 promotes SMSCs chondrogenic differentiation by targeting the MMP3, MMP13, and GATA3.
An esterase-responsive ibuprofen nano-micelle pre-modified embryo derived nucleus pulposus progenitor cells promote the regeneration of intervertebral disc degeneration.
PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway.
Thermosensitive hydrogel for cartilage regeneration via synergistic delivery of SDF-1α like polypeptides and kartogenin.
Experimental study of miR-503 regulating the activity as well as the function of degenerated human nucleus pulposus cells of the intervertebral disc through inhibiting Wnt pathway.
A comprehensive analysis of single-cell RNA transcriptome reveals unique SPP1+ chondrocytes in human osteoarthritis.
Stevioside protects primary articular chondrocytes against IL-1β-induced inflammation and catabolism by targeting integrin.
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway.
Silencing of NOTCH3 Signaling in Meniscus Smooth Muscle Cells Inhibits Fibrosis and Exacerbates Degeneration in a HEYL-Dependent Manner.
tsRNA-04002 alleviates intervertebral disk degeneration by targeting PRKCA to inhibit apoptosis of nucleus pulposus cells.
Du Huo Ji Sheng Tang inhibits Notch1 signaling and subsequent NLRP3 activation to alleviate cartilage degradation in KOA mice.
Wound Gel with Antimicrobial Effects Based on Polyvinyl Alcohol and Functional Aryloxycyclotriphosphazene.
TNF-α activates RELA expression via TNFRSF1B to upregulate OPA1 expression and inhibit chondrogenic differentiation of human adipose stem cells.
EIF4A3-Induced Upregulation of hsa_circ_0040039 is a Biomarker and Aggravates IL-1β-Stimulated Intervertebral Disc Degeneration.
Activating Mitochondrial Sirtuin 3 in Chondrocytes Alleviates Aging-Induced Fibrocartilage Layer Degeneration and Promotes Healing of Degenerative Rotator Cuff Injury.
Exosomal miR-429 derived from adipose-derived stem cells ameliorated chondral injury in osteoarthritis via autophagy by targeting FEZ2.
Targeting macrophagic PIM-1 alleviates osteoarthritis by inhibiting NLRP3 inflammasome activation via suppressing mitochondrial ROS/Cl(-) efflux signaling pathway.
Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy.
Pelargonidin ameliorates inflammatory response and cartilage degeneration in osteoarthritis via suppressing the NF-κB pathway.
Novel insights into the effect of deer IGF-1 on chondrocyte viability and IL-1β-induced inflammation response.
Activation of the kynurenine-aryl hydrocarbon receptor axis impairs the chondrogenic and chondroprotective effects of human umbilical cord-derived mesenchymal stromal cells in osteoarthritis rats.
Increased FGFR3 is involved in T-2 toxin-induced lesions of hypertrophic cartilage associated with endemic osteoarthritis.
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.
Hypoxia-Inducible Factor-1α Protects Against Intervertebral Disc Degeneration Through Antagonizing Mitochondrial Oxidative Stress.
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Indirubin protects chondrocytes and alleviates OA by inhibiting the MAPK and NF-κB pathways.
Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways.
Astaxanthin Promotes the Survival of Adipose-Derived Stem Cells by Alleviating Oxidative Stress via Activating the Nrf2 Signaling Pathway.
Matrix Stiffness Activating YAP/TEAD1-Cyclin B1 in Nucleus Pulposus Cells Promotes Intervertebral Disc Degeneration.
Hypoxia dissociates HDAC6/FOXO1 complex and aggregates them into nucleus to regulate autophagy and osteogenic differentiation.
Tranexamic Acid Causes Chondral Injury Through Chondrocytes Apoptosis Induced by Activating Endoplasmic Reticulum Stress.
Enhancement and Repair of Degenerative Intervertebral Disc in Rats Using Platelet-Rich Plasma/Ferulic Acid Hydrogel.
Cabozantinib prevents AGEs-induced degradation of type 2 collagen and aggrecan in human chondrocytes.
MiR-146b-5p enriched bioinspired exosomes derived from fucoidan-directed induction mesenchymal stem cells protect chondrocytes in osteoarthritis by targeting TRAF6.
Growth differentiation factor 5 inhibits lipopolysaccharide-mediated pyroptosis of nucleus pulposus mesenchymal stem cells via RhoA signaling pathway.
Ginsenoside compound K alleviates osteoarthritis by inhibiting NLRP3‑mediated pyroptosis.
Exosomes derived from bone marrow mesenchymal stem cells pretreated with decellularized extracellular matrix enhance the alleviation of osteoarthritis through miR-3473b/phosphatase and tensin homolog axis.
ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-κB signaling pathway.
ADRM1/RPN13 attenuates cartilage extracellular matrix degradation via enhancing UCH37-mediated ALK5 deubiquitination.
Injectable photocrosslinking spherical hydrogel-encapsulated targeting peptide-modified engineered exosomes for osteoarthritis therapy.
Kartogenin-loaded hydrogel promotes intervertebral disc repair via protecting MSCs against reactive oxygen species microenvironment by Nrf2/TXNIP/NLRP3 axis.
Piezo1-mediated mechanotransduction promotes entheseal pathological new bone formation in ankylosing spondylitis.
Comparative transcriptome analysis provides insight into the molecular targets and signaling pathways of deer TGF-1 regulating chondrocytes proliferation and differentiation.
Withdrawn: X. Chen, Y. Li, M. Zhang, X. Wu, J. Zhu. Silencing LCK inactivates the NF-κB pathway to attenuate cartilage injury in osteoarthritis: An in vivo and in vitro study, published in The Journal of Gene Medicine.
The journal of gene medicine 2023 Apr;25(4):e3387
Lithium-Containing Biomaterials Stimulate Cartilage Repair through Bone Marrow Stromal Cells-Derived Exosomal miR-455-3p and Histone H3 Acetylation.
Integrated Cascade Nanozyme Remodels Chondrocyte Inflammatory Microenvironment in Temporomandibular Joint Osteoarthritis via Inhibiting ROS-NF-κB and MAPK Pathways.
Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways.
Structural and biofunctional evaluation of decellularized jellyfish matrices.
BRD4 Inhibition Suppresses Senescence and Apoptosis of Nucleus Pulposus Cells by Inducing Autophagy during Intervertebral Disc Degeneration: An In Vitro and In Vivo Study.
Scrapie-Responsive Gene 1 Promotes Chondrogenic Differentiation of Umbilical Cord Mesenchymal Stem Cells via Wnt5a.
DPSCs Protect Architectural Integrity and Alleviate Intervertebral Disc Degeneration by Regulating Nucleus Pulposus Immune Status.
Gastrocnemius Muscle Injury Is the Condition to Induce Cartilage Degeneration of the Rabbit Tibiofemoral Joint: A New Perspective.
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Zoledronate promotes ECM degradation and apoptosis via Wnt/β-catenin.
Corosolic Acid Protects Rat Chondrocytes Against IL-1β-Induced ECM Degradation by Activating Autophagy via PI3K/AKT/mTOR Pathway and Ameliorates Rat Osteoarthritis.
3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy.
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
Innate/Inflammatory Bioregulation of Surfactant Protein D Alleviates Rat Osteoarthritis by Inhibiting Toll-Like Receptor 4 Signaling.
Saikosaponin D Inhibited IL-1β Induced ATDC 5 Chondrocytes Apoptosis In Vitro and Delayed Articular Cartilage Degeneration in OA Model Mice In Vivo.
Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway.
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Scutellarin Protects Against Mitochondrial Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation to Attenuate Intervertebral Disc Degeneration.
Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes.
Omentin-1 promoted proliferation and ameliorated inflammation, apoptosis, and degeneration in human nucleus pulposus cells.
Achyranthoside D (AD) improve intervertebral disc degeneration through affect the autophagy and the activation of PI3K/Akt/mTOR pathway.
Vasorin-containing small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system.
Suramin enhances chondrogenic properties by regulating the p67(phox)/PI3K/AKT/SOX9 signalling pathway.
Sinensetin attenuates IL-1β-induced cartilage damage and ameliorates osteoarthritis by regulating SERPINA3.
Disrupted tenogenesis in masseter as a potential cause of micrognathia.
Implementation of Photosensitive, Injectable, Interpenetrating, and Kartogenin-Modified GELMA/PEDGA Biomimetic Scaffolds to Restore Cartilage Integrity in a Full-Thickness Osteochondral Defect Model.
Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes.
Drugging the circadian clock feedback cycle to ameliorate cartilage degeneration.
Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages.
BAG3 protects chondrocytes against lumbar facet joint osteoarthritis by regulating autophagy and apoptosis.
Endoplasmin regulates differentiation of tonsil-derived mesenchymal stem cells into chondrocytes through ERK signaling.
Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis.
Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats.
Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration.
The anti-inflammation effect of strontium ranelate on rat chondrocytes with or without IL-1β in vitro.
Mechanical loading mitigates osteoarthritis symptoms by regulating the inflammatory microenvironment in a mouse model.
Isorhynchophylline ameliorates the progression of osteoarthritis by inhibiting the NF-κB pathway.
Upregulation of P2Y12 inhibits chondrocyte apoptosis in lumbar osteoarthritis through the PI3K/AKT signaling pathway.
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
MMP-10 Deficiency Effects Differentiation and Death of Chondrocytes Associated with Endochondral Osteogenesis in an Endemic Osteoarthritis.
BMSC-derived exosomes promote tendon-bone healing after anterior cruciate ligament reconstruction by regulating M1/M2 macrophage polarization in rats.
Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1.
Folic Acid Inhibits Aging-Induced Telomere Attrition and Apoptosis in Astrocytes In Vivo and In Vitro.
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Chondroprotective effects of multiple PRP injections in osteoarthritis by apoptosis regulation and increased aggrecan synthesis- Immunohistochemistry based Guinea pig study.
A plant-derived natural photosynthetic system for improving cell anabolism.
Exosome modification to better alleviates endoplasmic reticulum stress induced chondrocyte apoptosis and osteoarthritis.
Freeze-casting osteochondral scaffolds: The presence of a nutrient-permeable film between the bone and cartilage defect reduces cartilage regeneration.
Nodakenin attenuates cartilage degradation and inflammatory responses in a mice model of knee osteoarthritis by regulating mitochondrial Drp1/ROS/NLRP3 axis.
Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway.
An Injectable Hydrogel Scaffold Loaded with Dual-Drug/Sustained-Release PLGA Microspheres for the Regulation of Macrophage Polarization in the Treatment of Intervertebral Disc Degeneration.
Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells.
Knee Loading Enhances the Migration of Adipose-Derived Stem Cells to the Osteoarthritic Sites Through the SDF-1/CXCR4 Regulatory Axis.
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis.
Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis.
Reducing Inflammation and Vascular Invasion in Intervertebral Disc Degeneration via Cystathionine-γ-Lyase Inhibitory Effect on E-Selectin.
Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes.
Exosomes Isolated From Bone Marrow Mesenchymal Stem Cells Exert a Protective Effect on Osteoarthritis via lncRNA LYRM4-AS1-GRPR-miR-6515-5p.
Single-Cell Profiles of Age-Related Osteoarthritis Uncover Underlying Heterogeneity Associated With Disease Progression.
Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.
MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis.
Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3.
Deletion of p16 accelerates fracture healing in geriatric mice.
Baicalein Alleviates Osteoarthritis Progression in Mice by Protecting Subchondral Bone and Suppressing Chondrocyte Apoptosis Based on Network Pharmacology.
Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect.
Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development.
Maresin-1 suppresses IL-1β-induced MMP-13 secretion by activating the PI3K/AKT pathway and inhibiting the NF-κB pathway in synovioblasts of an osteoarthritis rat model with treadmill exercise.
Combination of graphene oxide and platelet-rich plasma improves tendon-bone healing in a rabbit model of supraspinatus tendon reconstruction.
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro.
Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis.
SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.
Interleukin‑Iβ promotes cartilage degeneration by regulating forkhead box protein O4 and type Ⅱ collagen.
LncRNA NONHSAT030515 promotes the chondrogenic differentiation of human adipose-derived stem cells via regulating the miR-490-5p/BMPR2 axis.
Hyaluronic acid hydrogel encapsulated BMP-14-modified ADSCs accelerate cartilage defect repair in rabbits.
SNHG16/miR-485-5p/BMP7 axis modulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.
Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.
Comparison of chondrogenesis-related biological behaviors between human urine-derived stem cells and human bone marrow mesenchymal stem cells from the same individual.
Circular RNA circPDE4D Protects against Osteoarthritis by Binding to miR-103a-3p and Regulating FGF18.
Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration.
Silencing BLNK protects against interleukin-1β-induced chondrocyte injury through the NF-κB signaling pathway.
The characterization, cytotoxicity, macrophage response and tissue regeneration of decellularized cartilage in costal cartilage defects.
Shockwave Treatment Enhanced Extracellular Matrix Production in Articular Chondrocytes Through Activation of the ROS/MAPK/Nrf2 Signaling Pathway.
LncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p/ADAMTS5 pathway.
Role of the hippo signaling pathway in the extracellular matrix degradation of chondrocytes induced by fluoride exposure.
Sulforaphane protects against oxidative stress‑induced apoptosis via activating SIRT1 in mouse osteoarthritis.
ZIP8 mediates the extracellular matrix degradation of nucleus pulposus cells via NF-κB signaling pathway.
Simultaneous Recruitment of Stem Cells and Chondrocytes Induced by a Functionalized Self-Assembling Peptide Hydrogel Improves Endogenous Cartilage Regeneration.
OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.
Steady Augmentation of Anti-Osteoarthritic Actions of Rapamycin by Liposome-Encapsulation in Collaboration with Low-Intensity Pulsed Ultrasound.
Matrisome Provides a Supportive Microenvironment for Skin Functions of Diverse Species.
MSCs reduce airway remodeling in the lungs of asthmatic rats through the Wnt/β-catenin signaling pathway.
Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression.
MicroRNA-675-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GNG5.
Sialic acid-modified chitosan oligosaccharide-based biphasic calcium phosphate promote synergetic bone formation in rheumatoid arthritis therapy.
L-polylactic acid porous microspheres enhance the mechanical properties and in vivo stability of degummed silk/silk fibroin/gelatin scaffold.
Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice.
p-Coumaric Acid Attenuates IL-1β-Induced Inflammatory Responses and Cellular Senescence in Rat Chondrocytes.
Overexpression of miR-10a-5p facilitates the progression of osteoarthritis.
MicroRNA-132 upregulation promotes matrix degradation in intervertebral disc degeneration.
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Jiang J, Xu Y, Dai T, Chen J, Li S, Meng Q
PloS one 2026;21(2):e0342242
PloS one 2026;21(2):e0342242
Ultrasound-responsive piezoelectric hydrogel attenuates oxidative stress-induced nucleus pulposus senescence via AMPK-FOXO1a-mediated mitophagy for intervertebral disc regeneration.
Wu W, Cheng Z, Shi P, Gao H, Chen Y, Zhang A, Chen X, Wu W, Zhang Y
Biomaterials 2026 May;328:123828
Biomaterials 2026 May;328:123828
Cinnamyl Alcohol Attenuates Osteoarthritis Progression via PIGR-Mediated Regulation of Chondrocyte Senescence and Cartilage Homeostasis.
Zhu Q, You Q, Deng J, Tang H, Hu Y, Liao Y, Miao Y
Journal of medicinal food 2026 May;29(5):279-293
Journal of medicinal food 2026 May;29(5):279-293
Detoxification of T-2 toxin in human chondrocytes due to its hydroxylation by carboxylesterases and arylacetamide deacetylase in the liver.
Cheng S, Shi S, Cheng B, Liu C, Yang X, Liu L, Liu H, Wen Y, Tinkov AA, Skalny AV, Jia Y, Zhang F
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2026 May;211:116007
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2026 May;211:116007
Huzhang-Xiangbaji compounds enhance the repair of meniscal cartilage by inhibiting ferroptosis and inflammatory microenvironment.
Li J, Zhou J, Zhang G, Ding N, Kuang Z, Wang J, Liu N, Jia G, Jiang M, Wu S, Yang J, Ding X, Lei Z, Nie Y, Zhang Y, Li Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158008
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158008
Targeted knockdown of Piezo1 in synovial macrophages attenuates osteoarthritis development.
Yan Z, Wu D, Zhao H, Guan H, Chen J, Huang C, Chen X, Deng X, Hu J, Wang J, Zhang Y
Journal of orthopaedic translation 2026 Mar;57:101053
Journal of orthopaedic translation 2026 Mar;57:101053
Biomimetic mineralized xenogenic acellular cartilage matrix promotes the repair of osteochondral defects and the recovery of motor function.
Wei Y, Liao H, Guo H, Li Z, Zhao J, Yeung KWK, Chen S, Zeng C
Biomaterials 2026 Mar;326:123722
Biomaterials 2026 Mar;326:123722
Selective Visualization of Type II Collagen Using Sum-Frequency Generation (SFG).
Khandani S, Palacios YYL, Savage H, Chavez L, Potma EO
Journal of biophotonics 2026 Mar;19(3):e70258
Journal of biophotonics 2026 Mar;19(3):e70258
Targeting CCNB1 Repressed Cartilage Degradation Induced by Inflammation Through NF-κB Pathway in Osteoarthritis.
Li H, Qiao Y, Ding M, Liu Y
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2026 Mar-Apr;74(2):235-248
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2026 Mar-Apr;74(2):235-248
WDR63 enhances the chondrogenic differentiation and regenerative potential of stem cell from apical papilla by facilitating vimentin function to promote mitochondrial fission.
Zhou J, Cao Y, Sun Z, Huang Y, Zhu M, Fan Z
Stem cell research & therapy 2026 Mar 8;17(1)
Stem cell research & therapy 2026 Mar 8;17(1)
Development of Intervertebral Disc Organoids through Directed Differentiation of Mesenchymal Stem Cells and Hierarchical 3D Printing.
Wu D, Zhu D, Zhou X, Li G, Zhang X, Ma L, Liang H, Tong B, Lei J, Wang H, Ke W, Feng X, Wang K, Tan L, Shi Y, Yang C, Wang B
ACS nano 2026 Mar 31;20(12):9619-9637
ACS nano 2026 Mar 31;20(12):9619-9637
Natural photosynthetic system for restoring homeostasis of animal organelle interaction network.
Xia C, Dai Z, Wang Y, Yu J, Wang Z, Huang Z, Pan K, Yang K, Chen Y, Zhong P, Gu C, Fan S, Lin X, Chen P
Nature communications 2026 Mar 31;17(1)
Nature communications 2026 Mar 31;17(1)
Microneedle patches deliver targeted GLP-1RAs-loaded nanoparticles for the treatment of rheumatoid arthritis.
Zhang H, Liu Y, Zhang S, Wang Z, Zhang X, Zhang Y, Zhang J, Liang S, Li C, Su M, Tian Z, Luo L
Journal of nanobiotechnology 2026 Mar 16;24(1)
Journal of nanobiotechnology 2026 Mar 16;24(1)
Recycling senescent cell lipids for targeted senotherapy.
Ji X, He X, Cai H, Tang P, Zhou H, Wang J, Wu Y, Zhou J, Lin Z, Xu K, Lin C, Wu X, Wang K, Liu W, Feng G, Yan S, Jiang G, Qu Z, Qi Y
Nature communications 2026 Mar 13;17(1)
Nature communications 2026 Mar 13;17(1)
ALOX5 knockdown alleviates cartilage damage in osteoarthritis by inhibiting the NF-κB signaling pathway.
Cheng G, Chen K, Wang Z, Chen H, Shen Y
Cytokine 2026 Jun;202:157150
Cytokine 2026 Jun;202:157150
Pterostilbene inhibits ferritinophagy-mediated ferroptosis via the NRF2/NCOA4/FTH1 axis and alleviates intervertebral disc degeneration through nanoliposomal delivery.
Song Z, Yan M, Lv X, Zhang S, Kou H, Han H, Wang Z, Chen Y, Shi L, Shao Z, Hu B, Chen S, Liu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158051
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158051
Long-acting triamcinolone acetonide prodrug microcrystals for sustained intra-articular treatment of osteoarthritis.
Wang X, Dong Y, Lin X, Deng X, Li X, Shi X, Zhou Y, Yao X, Yu N, Guo S
Journal of controlled release : official journal of the Controlled Release Society 2026 Jun 10;394:114868
Journal of controlled release : official journal of the Controlled Release Society 2026 Jun 10;394:114868
Collagen II hydrogel-mediated sustained delivery of lacosamide attenuates cartilage degeneration and pain in osteoarthritis.
He C, Huang G, Moradi L, Bi J, Yang X, Liu X, Cui X, Varthi A, Wiznia DH, Waxman SG, Fu W, Liu CJ
Bioactive materials 2026 Jul;61:640-656
Bioactive materials 2026 Jul;61:640-656
A dual-functional hydrogel integrating adhesive and lubricating interfaces for mitochondrial protection-Driven cartilage regeneration.
Wu Z, Wu G, Zhu Y, Zheng G, Wang T, Liu J, Shen Z, Wang X, Bei X, Xu Y, Li J, Yuan R, Wu Z, Guo Y, Zhang Y, Peng F
Bioactive materials 2026 Jul;61:622-639
Bioactive materials 2026 Jul;61:622-639
Microenvironment-educated MSC-EVs loaded injectable smart hydrogel for targeting senescent nucleus pulposus cells and inhibiting ferroptosis against intervertebral disc degeneration.
Wu W, Cheng Z, Shi P, Gao H, Chen X, Wu W, Yu Z, Yang C, Zhang Y
Bioactive materials 2026 Jul;61:555-576
Bioactive materials 2026 Jul;61:555-576
Chondrocyte-Targeted Nanoparticles Loaded with N-Acetylcysteine Protect Articular Cartilage and Attenuate Osteoarthritis by Inhibiting Ferroptosis via Glutathione Maintenance.
Wang S, Zhang F, Zhou X, Yang J, Li Z, Li S, Lu Q, Sun H, Liu P
Small science 2026 Jan;6(1):e202500440
Small science 2026 Jan;6(1):e202500440
Extracellular vesicles originating from induced pluripotent stem cell-derived chondrocytes facilitate the regeneration of osteoarthritic cartilage.
Hu Y, Cheng P, Jia L, Hao X, Ding G, Han M, Fan J, Lu W, Zhou C, Luo Z, Yang L
Journal of orthopaedic translation 2026 Jan;56:101035
Journal of orthopaedic translation 2026 Jan;56:101035
Mechano-Iontronic Hydrogels Generating Biomimetic Endogenous Bioelectricity for Promoting Cartilage Regeneration.
Li L, Li Z, Yue M, Shao Y, Wang J, Song Y, Wang ZL, Zhou Y, Pu X
Advanced materials (Deerfield Beach, Fla.) 2026 Jan;38(2):e14604
Advanced materials (Deerfield Beach, Fla.) 2026 Jan;38(2):e14604
Pharmacological inhibition of PGK1 by genipin reduces inflammation and oxidative damage in osteoarthritis.
Li M, Peng Y, Xiao Q, Chen S, Zhang C, Chen H, Zhao Y, Chang S, Qiu L, Zhang L, Guo X, Fu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157729
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157729
Psoralen promotes SOCS5 to inhibit JAK/STAT3 to alleviate cartilage degeneration in knee osteoarthritis.
Zhang J, Tian J, Weiyang W, Yang Y, Li Y, Ye X, Huang D, Xu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157643
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157643
GIPC2 regulation of the PKM2/SREBP1 signaling axis controls adipogenic differentiation of mesenchymal stem cells.
Wang J, Xin C, Sun Z, Zhao M, Zan Y, Lv Z, Zhu S, Liu J, Wang L
Cell death & disease 2026 Jan 7;17(1):5
Cell death & disease 2026 Jan 7;17(1):5
An injectable dihydroartemisinin nanocomposite hydrogel for dual-targeting PANoptosis and inflammation to treat osteoarthritis.
Li Q, Chen L, Sun Y, Wang C, Sun Y, Lu K, Li L, Sun H, Liu M
Journal of nanobiotechnology 2026 Jan 29;24(1)
Journal of nanobiotechnology 2026 Jan 29;24(1)
MEGF8-mediated GDF8 phosphorylation drives TGF-β hyperactivation in osteoarthritis cartilage degeneration: Mechanism and targeted intervention.
Li W, Jia J, Xie R, Ni X, Cheng X, Kang S, Pan Y
Life sciences 2026 Jan 15;385:124139
Life sciences 2026 Jan 15;385:124139
Engineered microalgae-driven gel platform promotes the repairing of senescence-associated intervertebral disc degeneration in rats and goats.
Wang Y, Xu T, Wang H, Cai X, Gao S, Liang W, Deng Q, Yakefu A, Maimaiti M, Xun C, Ma L, Sheng W
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114500
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114500
Microenvironment-targeted strontium delivery system reshapes redox homeostasis to halt degenerative cascades in intervertebral discs.
Cheng H, A C, Shu Z, Zhao H, Wang L, Huang C, Li W, Fang X, Wu H, Bao X, Fang Z
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114449
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114449
Dopamine-functionalized bioinspired pre-chondrogenic hydrogel for cell-free cartilage regeneration.
Zhu Q, Zhu L, Lang J, Zhu J, Chen D, Huang Y, Zhang J, Wu X, Hu J, Ji J, Yang Q, Du Y
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114407
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114407
Forsythoside B protects cartilage and subchondral bone in osteoarthritis by regulating the Nrf2/NF - κ B signaling pathway.
Zhang H, He Z, Wang H, Lu F, Chen H
International immunopharmacology 2026 Jan 1;168(Pt 1):115762
International immunopharmacology 2026 Jan 1;168(Pt 1):115762
PTPN22 as a therapeutic target in intervertebral disc degeneration: Modulating mitophagy and pyroptosis through the PI3K/AKT/mTOR axis.
Liang H, Yang S, Huang Y, Zhu Y, Wu Q, Wu Z, Li S, Shi Y, Chen Z, Jin H, Wang X
Journal of advanced research 2026 Feb;80:775-789
Journal of advanced research 2026 Feb;80:775-789
Dental Pulp Stem Cell-Derived Intracellular Vesicles Promote Cartilage Regeneration and Alleviate Pain in Temporomandibular Joint Osteoarthritis.
Shu C, Luo Y, Liu Y, Wang J, Qin Q, Li Z, Situ J, Liu X, Wang X, He Y, Ye Q
International dental journal 2026 Feb;76(1):103974
International dental journal 2026 Feb;76(1):103974
Injectable microgels loaded with programmable WELNs based on mendelian randomization macroanalysis alleviate osteoarthritis by restoring the circadian rhythm.
Yan R, Li W, Zhao D, Zhao J, Ying S, Xiang L, Wang H, He T, Zhao C, Cui W, Zheng C, Yang L
Bioactive materials 2026 Feb;56:483-508
Bioactive materials 2026 Feb;56:483-508
Integrating TWAS, chemical-genomic networks, and experimental models: melatonin as a ferroptosis inhibitor in osteoarthritis therapy.
Feng R, Aihaiti Y, Yu H, Xu K, Lu C, Xu P
Clinical rheumatology 2026 Feb;45(2):1559-1572
Clinical rheumatology 2026 Feb;45(2):1559-1572
Betamethasone injection at different stages showing different effect on tendon-to-bone healing in a rat rotator cuff tear model.
Chen M, Xu H, Luo C, Wang H, Cheng J, Guo Y, Ju F, Sun Y, Zhu Z
Journal of shoulder and elbow surgery 2026 Feb;35(2):e344-e352
Journal of shoulder and elbow surgery 2026 Feb;35(2):e344-e352
Remodeling Cellular Uptake via Inducing Clustering of Urokinase Receptors in Hydrogel Microspheres for Alleviating Cartilage Senescence.
Lin Z, Wu C, Du Y, Zhao D, Li Y, Wang L, Kang Y, Li Z, Zuo R, Cui W, Zhao J
Advanced healthcare materials 2026 Feb;15(5):e04034
Advanced healthcare materials 2026 Feb;15(5):e04034
Synergistic Effects of Nutritional Formula on Joint Inflammation Through Modulation of Bone Metabolism in Rats.
Wang H, Wang Y, Fan D, Niu Z, Su H, Li A, Kou R, Yue Z, Wu S, Lv H, Ji X, Hu Y, Zhao Y, Wang S
Nutrients 2026 Feb 26;18(5)
Nutrients 2026 Feb 26;18(5)
Integrative analysis of single-cell RNA sequencing, bulk RNA sequencing, and proteomic data identified NOTCH3 as a hub gene contributing to human intervertebral disc fibrosis.
Ding Q, Chen X, Zheng Q, Dou Q, Zuo C, Wang Q, Shen C
Scientific reports 2026 Feb 26;16(1)
Scientific reports 2026 Feb 26;16(1)
Activated Rac1 promotes chondrocyte apoptosis through the NF-κB pathway in lumbar facet joint osteoarthritis.
Wang X, Xue P, Zhang J, Jin H, Jiang J, Xu G, Cui Z
Journal of molecular histology 2026 Feb 25;57(2)
Journal of molecular histology 2026 Feb 25;57(2)
Synergistic microenvironment therapy: a dual-function nanogel of supramolecular collagen ll-mimetic matrix and antioxidant MXene for attenuating intervertebral disc degeneration.
Lyu G, Gao Z, Cao Z, Zhou Q, Chen Y, Yang S, Liang H, Lu X, Li S, Wang X, Sun S, Gao X, Zhou Y, Wu A, Zhou X, Wang X
Journal of nanobiotechnology 2026 Feb 19;24(1)
Journal of nanobiotechnology 2026 Feb 19;24(1)
HACE1 alleviates intervertebral disc degeneration by inhibiting ferroptosis in nucleus pulposus cells.
Xia J, Zhang W, Jiang Y, Li T, Dong H, Zhu L, Xia Q, Zhao Y, Yi J, Weng Z, Feng S, Xin Z
Scientific reports 2026 Feb 13;16(1)
Scientific reports 2026 Feb 13;16(1)
The promoting roles of GLP1R and GIPR in stemness maintenance and multiple lineage-specific differentiation of PDLSCs.
Shen Y, Zhang M, Yang T, Wu Y, Qiu Y, Zhang L, Li F, Chen M, Chen Q, Wei W, Li H, Shen Y
Cellular & molecular biology letters 2026 Feb 11;31(1):22
Cellular & molecular biology letters 2026 Feb 11;31(1):22
KLK8 promotes cartilage degradation and pyroptosis in osteoarthritis by activating the NF-κB and NLRP3 inflammasome pathways.
Xu L, Jiang Z, Li H
Tissue & cell 2026 Aug;101:103427
Tissue & cell 2026 Aug;101:103427
Injectable microgels carrying engineered biomimetic nanoparticles for osteoarthritis therapy via dual-targeted senescent chondrocyte clearance and endogenous repair promotion.
Wang P, Zhao H, Zhang S, Guo Y, Xing X, Zhou S, Yang S, Wang F, Chen W, Wang J, Zhang Y
Bioactive materials 2026 Apr;58:486-504
Bioactive materials 2026 Apr;58:486-504
An engineered triple-network alginate/gelatin hydrogel mediates osteochondral regeneration through temporal regulation of the PI3K-AKT pathway.
Zhu Y, Leng P, Liang W, Xu W, Liang H, Yang Y, Si X, Liu X, Yang X, Shi C, Liu M
International journal of biological macromolecules 2026 Apr;358:151622
International journal of biological macromolecules 2026 Apr;358:151622
Lipid-modulating hyaluronic acid hydrogel promotes chondrogenesis of osteoarthritis progenitor cells for weight-bearing cartilage repair.
Liu W, Wang J, Wang W, Li M, Liu N, Luo M, Yao X
International journal of biological macromolecules 2026 Apr;353:151225
International journal of biological macromolecules 2026 Apr;353:151225
Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression.
Luo J, Yu T, Hu P, Liu J
Non-coding RNA research 2026 Apr;17:76-89
Non-coding RNA research 2026 Apr;17:76-89
Targeting adipocyte ESRRA alleviates osteoarthritis via interrupting inter-organelle crosstalk of complement C3-CFD-MAC cascade.
Huang T, Wang Z, Gao L, Gao J, Lu Z, Li P, Choy CH, Yuan Z, Zhong Y, Geng CA, Wang H, Yeung KWK, Li B, Pan H, Chen D, Guan M
Bone research 2026 Apr 29;14(1)
Bone research 2026 Apr 29;14(1)
Identification of Autophagy-related Genes of the Osteoarthritis Using Machine Learning Algorithm.
Zhang Z, Wang H, Cheng X, Zhang Z, Hou Z, Liu Z, Gao Y
Biochemical genetics 2026 Apr 21;
Biochemical genetics 2026 Apr 21;
Supramolecular dynamic hydrogels loaded with bevacizumab nanoparticles promote hyaline cartilage regeneration by inhibiting angiogenesis.
Li A, Jiao Z, Liu P, Lin M, Chen J, Liang R, Huang J, Yue Y, Cao F, You H, Zeng H, Zhang K, Lin J
Acta biomaterialia 2026 Apr 20;
Acta biomaterialia 2026 Apr 20;
HDAC6 exacerbates osteoarthritis by promoting macrophage inflammation-mediated chondrocyte degeneration.
Wang S, Fu L, Qiu W, Ouyang J, Song D, Song Z, Zhu Y, Yan Z, Jin F, Lu YJ, Liu G
International immunopharmacology 2026 Apr 1;174:116399
International immunopharmacology 2026 Apr 1;174:116399
Biphasic Scaffolds Functionalized with Piezoelectric Nanozymes for Osteochondral Defect Regeneration.
Ding H, Zhao C, Hu Y, Tong C, Gong X, Yang Y, Fang Y, Li J, Dai S, Chen W, Dong S
Advanced healthcare materials 2026 Apr 1;:e00012
Advanced healthcare materials 2026 Apr 1;:e00012
Novel lncRNA LncMSTRG.11341.25 Promotes Osteogenic Differentiation of Human Bone Marrow Stem Cells via the miR-939-5p/PAX8 Axis.
Ni F, Li J, Yin Q, Chen Y, Shao Z, Wang H
Research (Washington, D.C.) 2025;8:0601
Research (Washington, D.C.) 2025;8:0601
Decoding Endoplasmic Reticulum Stress on Chondrocyte Driving Osteoarthritis Development through Integrating Single-Cell and Transcriptomic Profiling.
Zhang Z, Cheng D, Dang J, Wang X, Fan H, Liu D
International journal of medical sciences 2025;22(15):3906-3923
International journal of medical sciences 2025;22(15):3906-3923
Microfluidic Synthesis of miR-200c-3p Lipid Nanoparticles: Targeting ZEB2 to Alleviate Chondrocyte Damage in Osteoarthritis.
Zheng D, Chen T, Yang K, Yin G, Chen Y, Gui J, Xu C, Lv S
International journal of nanomedicine 2025;20:505-521
International journal of nanomedicine 2025;20:505-521
Acupotomy Ameliorates KOA Related Chondrocyte Premature Senescence Through YAP/FOXD1 Pathway.
Ma Y, Hu T, Liu N, Guo C, Xing L, Ma W, Cui Y, Chen X
Journal of pain research 2025;18:2011-2023
Journal of pain research 2025;18:2011-2023
Astragaloside IV Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis via the p53/SLC7A11/GPX4 Axis.
Tang Z, Cheng L, Li M, Chen J, Huang C
Journal of inflammation research 2025;18:16169-16186
Journal of inflammation research 2025;18:16169-16186
Passive hydrotherapy preserves cartilage and muscle integrity in a murine osteoarthritis model: potential role of integrin αV/TGF-β mechanotransduction.
Di W, Songyang W, Ruibing F, Yong H, Hao H, Xiaofeng D, Yang R, Yunxiang D, Gang W
Frontiers in physiology 2025;16:1633618
Frontiers in physiology 2025;16:1633618
IL-19 suppresses Hippo signaling via modulating YAP1 phosphorylation in osteoarthritis.
Deng J, Gu J, Gong X, Tang H, Cai Y, Yang Y, Dong S, Zhao C
Frontiers in immunology 2025;16:1630253
Frontiers in immunology 2025;16:1630253
Thrombospondin-1 mitigates osteoarthritis progression by inhibiting mechanical stress-induced chondrocyte ferroptosis via the integrin/YAP pathway.
Wang S, Zhou X, Zhang F, Zhai H, Zhang Y, Guo Y
Frontiers in immunology 2025;16:1577234
Frontiers in immunology 2025;16:1577234
Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress.
Zhu Z, Huang Z, Zhang C, Xu B, Chen H, Pei S, Zhang B, Jie L, Shi X, Liu Y, Li Y, Shen X
Frontiers in pharmacology 2025;16:1501725
Frontiers in pharmacology 2025;16:1501725
Bone remodeling stimulated by Wnt-mediated mitophagy regulated extracellular vesicles in subchondral bone contributes to osteoarthritis development.
Gu Y, Zhou Q, Sheng S, Yang H, Huang D, Zhang Q, Zhang H, Cao Z, Zhang Y, Li Z, Jiang Y, Chen X, Jing Y, Wang C, Tan H, Xu K, Su J
Theranostics 2025;15(18):10007-10027
Theranostics 2025;15(18):10007-10027
Chronic cervical instability in mice and rats: a reproducible model to simulate human intervertebral disc degeneration.
Tu K, Tan J, Zeng G, Xu F, Liao D, Lu W, Zhao K, Chen Z, Zhou B, Dai X
PeerJ 2025;13:e20465
PeerJ 2025;13:e20465
Injectable hydrogel loaded with exosomes from hypoxic umbilical cord-derived mesenchymal stem cells alleviates intervertebral disc degeneration by reversing nucleus pulposus cell senescence.
Zhao X, Shi Y, Sun Z, Duan W, Chang L, Xu B, Lai K, Zhang J, Tian B, Tao W, Mi Z, Zhang M, Yang W, Luo Z, Ye Z
Regenerative biomaterials 2025;12:rbaf039
Regenerative biomaterials 2025;12:rbaf039
Low hydrostatic pressure promotes functional homeostasis of nucleus pulposus cells through the TRPV4/CRT/FA complex axis.
Hu J, Zhu Y, Pang Z, Li X, Zhang H, Li X, Gao Y, Wang Y, Li P, Zhou Q
Frontiers in medicine 2025;12:1531907
Frontiers in medicine 2025;12:1531907
A mouse coccygeal intervertebral disc degeneration model with tail-looping constructed using a suturing method.
Xie W, Huang Z, Huang Z, Luo D, Chen Z, Xie L, Zhu L, Liu H, Lian K, Alberton P, Docheva D, Lin D
Animal models and experimental medicine 2025 Sep;8(9):1645-1655
Animal models and experimental medicine 2025 Sep;8(9):1645-1655
Selenium nanozyme-crosslinked composite hydrogel for promoting cartilage regeneration in osteoarthritis via an integrated 'outside-in' and 'inside-out' strategy.
Gao W, Li S, Miao Y, Yuan G, Li G, Zhou G, Jia G, Yang X, Jin Y
Journal of colloid and interface science 2025 Sep;693:137612
Journal of colloid and interface science 2025 Sep;693:137612
Oxidative stress activates YAP/TEAD1/NCOA4 axis to promote ferroptosis of endplate chondrocytes and aggravate intervertebral disc degeneration.
Wang H, Liu X, Jing X, Zhang B, Liu X, Liu X, Jia F, Su C, Wang W, Cui X
Journal of orthopaedic translation 2025 Sep;54:8-25
Journal of orthopaedic translation 2025 Sep;54:8-25
3D-printed advanced scaffold armed with exosomes derived from human skeletal stem cell identified by single-cell RNA sequencing enhances osteochondral regeneration.
Lou W, Qiu X, Qin Y, Lu Y, Cao Y, Lu H
Bioactive materials 2025 Sep;51:231-256
Bioactive materials 2025 Sep;51:231-256
Optimal Timing for Initiating Postoperative Mobilization for Healing Enthesis in Onto-Surface Repair.
Naka T, Kumagai K, Ishikawa K, Inoue Y, Kusaba Y, Nagashima K, Watanabe D, Choe H, Ike H, Kobayashi N, Inaba Y
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2025 Sep;43(9):1535-1544
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2025 Sep;43(9):1535-1544
BRD-K20733377 inhibits ferroptosis and alleviates intervertebral disc degeneration via the STAT3/NFKB1 axis: a multiapproach study.
Sun H, You X, Li Z, Li Z, Hua B, Liu C, Zhang Y, Wu H, Zai S, Zhang L
Stem cell research & therapy 2025 Sep 29;16(1):531
Stem cell research & therapy 2025 Sep 29;16(1):531
Duhuo jisheng decoction alleviates osteoarthritis progression by mitigating ferroptosis in chondrocytes via the nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 axis.
Wu B, Yang Z, Duan J, Chen Z, Xiao J, Luo Z, Jian G, Wang H, Lu G
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120441
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120441
Paeoniflorin mitigates iron overload-induced osteoarthritis by suppressing chondrocyte ferroptosis via the p53/SLC7A11/GPX4 pathway.
Wu B, Luo Z, Chen Z, Lu Y, Duan J, Yang Z, Lu G
International immunopharmacology 2025 Sep 23;162:115111
International immunopharmacology 2025 Sep 23;162:115111
Amelioration of Post-traumatic Osteoarthritis by Iontophoretic Liposomal Strontium Ranelate Collaborated with Low-Intensity Pulsed Ultrasound in Rats.
Chen CH, Lin SL, Kuo SM, Lai JM, Shih WL, Shen PC, Kuo YW, Huang HH
International journal of molecular sciences 2025 Sep 10;26(18)
International journal of molecular sciences 2025 Sep 10;26(18)
A hydrogel-based drug delivery system reduces inflammation and oxidative stress to alleviate intervertebral disc degeneration.
Wang S, Zhai Y, Liu M, Cheng Z, Zhang J, Zhang H, Wang H, Hu Y, Li C, Luo Z
Acta biomaterialia 2025 Sep 1;203:229-244
Acta biomaterialia 2025 Sep 1;203:229-244
Sodium tanshinone IIA sulfonate alleviates osteoarthritis through targeting SIRT1.
Xu M, Sun X, Ma X, Qin Z, Gao X, Jin X, Sun H
Chinese medicine 2025 Sep 1;20(1):142
Chinese medicine 2025 Sep 1;20(1):142
cZFP609 Tethering BiP Alleviates Cartilage Degradation in Osteoarthritis via Remedying Aberrant ER-Mitochondrial Contacts.
Song Y, Luo JL, Zhang F, Shi J, Du S, Jiang HB, Zhang WD, Chen SY, Zhang DD, Kong P, Gao Y, Han M, Li H
MedComm 2025 Oct;6(10):e70405
MedComm 2025 Oct;6(10):e70405
Antioxidant functionalized double-net/TA dynamic hydrogel promotes cartilage regeneration through stabilization of chondrocyte phenotype.
Wu X, Wang H, Li C, Zhu Y, Wang Q, Zhang T, Fu Y, He A
Materials today. Bio 2025 Oct;34:102203
Materials today. Bio 2025 Oct;34:102203
Injectable Ca(2+)/Sr(2+)-crosslinked hydrogel with sustained release of LGK-974 for cartilage repair and osteoarthritis prevention via alleviating inflammatory microenvironment.
Wei X, Liu Y, Liu J, Zhao Z, Cui J, Sang D, Tang Y, Ding Y, Gao T, Xue Z, Lv S, Man Z, Li W, Li N
Materials today. Bio 2025 Oct;34:102164
Materials today. Bio 2025 Oct;34:102164
miR-204-5p Mitigates Disc Degeneration via SKI-Mediated Modulation of Apoptotic Signaling and Matrix Remodeling in Nucleus Pulposus.
Ran R, Gong CY, Wu ZL, Zhang SB, Zhang K, Zhou WM, Song W, Dong H, Shi YQ, Zhou KS, Zhang HH
The American journal of pathology 2025 Oct;195(10):1905-1920
The American journal of pathology 2025 Oct;195(10):1905-1920
Duhuo Jisheng decoction alleviates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the exosome-mediated miR-19b-3p/ACSL4 axis.
Feng J, Miao H, Xiao Z, Xu L, Wang Y, Cao X, Wang J, Wu Z, Xia P, Liu W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157113
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157113
Paeonol reduces IL-1β induced apoptosis and degeneration by regulating MAPK pathway in nucleus pulposus cells.
Yu C, Wei X, Wang J, Wang L, Wang J
Biochemical and biophysical research communications 2025 Oct 20;785:152687
Biochemical and biophysical research communications 2025 Oct 20;785:152687
Cytosolic phospholipase A2 as a therapeutic target for degenerative joint diseases.
Huang G, He C, Fu W, Bi J, Wang J, Wiznia DH, Liu CJ
Bone research 2025 Oct 15;13(1):86
Bone research 2025 Oct 15;13(1):86
CORM-3 mitigates osteoarthritis by anti-inflammation and enhancing autophagy via inhibiting MAPK and mTOR pathways.
Li J, Zeng Y, Wang S, Chen X, Huang H, Gan X, Kang H
International immunopharmacology 2025 Oct 10;163:115296
International immunopharmacology 2025 Oct 10;163:115296
Circular RNA PVT1 promotes osteoarthritis progression through the miR-550a-3p/CX3CR1 pathway: A mechanistic study.
Liu X, Li G, Yang L, Pan N, Tang S, Yu C, Zhang Q, Zeng L, Goswami A, Deng K, Liao X, Tian Y, Wu Y
International immunopharmacology 2025 Oct 10;163:115272
International immunopharmacology 2025 Oct 10;163:115272
Antioxidant taurine inhibits chondrocyte ferroptosis through upregulation of OGT/Gpx4 signaling in osteoarthritis induced by anterior cruciate ligament transection.
Zhou X, Yang Y, Qiu X, Deng H, Cao H, Liao T, Chen X, Huang C, Lin D, Ni G
Journal of advanced research 2025 Nov;77:551-567
Journal of advanced research 2025 Nov;77:551-567
Cuproptosis in osteoarthritis: Exploring chondrocyte cuproptosis and therapeutic avenues.
Hua H, Cheng F, Meng Z, Zhang A, Li M, Zhang M, Lou P, Zhu Y, Tong P, Zhang Y
Journal of orthopaedic translation 2025 Nov;55:293-308
Journal of orthopaedic translation 2025 Nov;55:293-308
An aptamer specifically targeting mCRP ameliorates experimental arthritis.
Wang Z, Xie D, Zhu P, Guo J, Cao C, Du Y, Lu A, Liang C
Journal of orthopaedic translation 2025 Nov;55:228-244
Journal of orthopaedic translation 2025 Nov;55:228-244
Therapeutic extracellular vesicles enriched with SNHG5 reprogram autophagy and macrophage polarization in osteoarthritis.
Wang Z, Zhang Y, Wang K, Xiang S, Guo C, Xu H
International journal of biological macromolecules 2025 Nov;330(Pt 1):147905
International journal of biological macromolecules 2025 Nov;330(Pt 1):147905
Reg3β promotes chondrocyte proliferation and ECM metabolism during acetabular roof remodeling in a rat model of DDH‑induced residual dysplasia.
Wang P, Li M, Wang W, Sun W, Zhen W, Sun Q, Ning B, Su G, Wang X
Molecular medicine reports 2025 Nov;32(5)
Molecular medicine reports 2025 Nov;32(5)
Yiqi Xugu HeJi restores cartilage metabolic homeostasis via AKT1-Thr473 activation in osteoarthritis.
Wu Z, Xu H, Qiao B, Zhu Y, Yuan R, Wu Z, Li S, Li J, Xu Y, Dong W, Guo Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157228
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157228
Ultrasound-triggered injectable piezoelectric nanocomposite hyaluronic acid-based hydrogel for modulating inflammation and chondrogenesis in osteoarthritis treatment.
Lin J, Li S, Peng Y, Qiu C, Yang M, Guo J, Yu B, Chen Y
Carbohydrate polymers 2025 Nov 1;367:123909
Carbohydrate polymers 2025 Nov 1;367:123909
The Effect of Platelet-Rich Plasma on Synovial Fibrosis and Cartilage Degeneration in Knee Osteoarthritis.
Zhang JY, Xiang XN, Wang Q, Wang XX, Guan AJ, He CQ, Yu X, He HC
The American journal of sports medicine 2025 May;53(6):1428-1439
The American journal of sports medicine 2025 May;53(6):1428-1439
Establishment and characterization of an inflammatory cartilaginous organoids model for organoid transplantation study.
Zhang Y, Fang Q, Peng Y, Liu H, Tang J, Ma R, Wang W
Journal of orthopaedic translation 2025 May;52:376-386
Journal of orthopaedic translation 2025 May;52:376-386
SHP2-mediated ROS activation induces chondrocyte paraptosis in osteoarthritis and is attenuated by low-intensity pulsed ultrasound.
Hou W, Shang X, Hao X, Pan C, Zheng Z, Zhang Y, Deng X, Chi R, Liu J, Guo F, Sun K, Xu T
Journal of orthopaedic translation 2025 May;52:233-248
Journal of orthopaedic translation 2025 May;52:233-248
Injectable visible light cross-linking aldehyde-based methacrylated hyaluronic acid hydrogels enhance cartilage repair via improved BMSC homing and chondrogenic differentiation.
Wang D, Zhong Q, Xu Y, Fu J, Xie J, Chen R, Lei M, Tang Z, Mai H, Li H, Shi Z, Zheng S, Cheng H
International journal of biological macromolecules 2025 May;307(Pt 2):141857
International journal of biological macromolecules 2025 May;307(Pt 2):141857
ZC3H13 Promotes NSUN4-Mediated Chondrocyte Mitochondrial Dysfunction and Pyroptosis in Temporomandibular Joint Osteoarthritis.
Chen Y, Ren H
Cartilage 2025 May 28;:19476035251339410
Cartilage 2025 May 28;:19476035251339410
Therapeutic potential of quercitrin in intervertebral disc degeneration: Targeting pyroptosis and inflammation.
Wu X, Pan Q, Yao C, Gong Y, Li Z, Tang F, Fang Z, Bao Y, Chen Y, Yu M, Wang Z, Jiang C, Hong Z
International immunopharmacology 2025 May 27;156:114680
International immunopharmacology 2025 May 27;156:114680
Nicotinamide Adenine Dinucleotide-Loaded Lubricated Hydrogel Microspheres with a Three-Pronged Approach Alleviate Age-Related Osteoarthritis.
Lin Y, Wu H, Wang J, He W, Hou J, Martin VT, Zhu C, Chen Y, Zhong J, Yu B, Lu A, Guan D, Qin G, Chen W
ACS nano 2025 May 13;19(18):17606-17626
ACS nano 2025 May 13;19(18):17606-17626
Conditional sequential delivery of ginkgetin and rapamycin orchestrates inflammation and autophagy to alleviate intervertebral disc degeneration.
Chen J, Gan X, Su S, Jiao S, Gong Z, Liu Z, Wu X, Jiang J, Zhang J, Wan J
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113556
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113556
Synergistic therapeutic effect of parecoxib and ilomastat combination in osteoarthritis via inhibition of IL-17/PI3K/AKT/NF-κB activity.
Feng X, Ma Y, Zhao Y, Zhao Z, Song Z, Lin L, Wang W
Molecular immunology 2025 Mar;179:94-105
Molecular immunology 2025 Mar;179:94-105
Piezo1 promotes intervertebral disc degeneration through the Ca(2+)/F-actin/Yap signaling axis.
Peng F, Sun M, Jing X, Chen F, Cao T, Li Z, Li T
Molecular medicine (Cambridge, Mass.) 2025 Mar 8;31(1):90
Molecular medicine (Cambridge, Mass.) 2025 Mar 8;31(1):90
circ_0000389 inhibits intervertebral disc degeneration by targeting the miR-346/KLF7 axis.
Liu C, Yu C, Duan Y, Li J, Chen X, Xu W, Qiu S
Acta biochimica et biophysica Sinica 2025 Mar 5;57(10):1636-1646
Acta biochimica et biophysica Sinica 2025 Mar 5;57(10):1636-1646
Reprogramming Macrophage Phenotype Using a Reactive Oxygen Species-Responsive Liposome Delivery System for Inflammation Microenvironment Remodeling and Osteoarthritis Treatment.
Lai P, Ma Y, Sang W, Zhou Q, Chen H, Wang C, Yin J, Wang T, Zhu L, Zhou X, He C, Ma J
ACS applied materials & interfaces 2025 Mar 26;17(12):17932-17947
ACS applied materials & interfaces 2025 Mar 26;17(12):17932-17947
Low intensity pulsed ultrasound alleviates synovial fibrosis in osteoarthritis via the PI3K/AKT pathway.
Liao Q, Chen J, Liu G
Scientific reports 2025 Mar 20;15(1):9644
Scientific reports 2025 Mar 20;15(1):9644
Selenium deficiency exacerbates cartilage degradation caused by HT-2 toxin via notch signaling pathway activation.
Meng P, Liu L, Jiang N, Hao S, Yao C, Liu H, Zhang Y, Zhang F, Jia Y, Guo X
European journal of nutrition 2025 Mar 19;64(3):129
European journal of nutrition 2025 Mar 19;64(3):129
LATS1-modulated ZBTB20 perturbing cartilage matrix homeostasis contributes to early-stage osteoarthritis.
Hao X, Zhao J, Jia L, Ding G, Liang X, Su F, Yang S, Yang Y, Fan J, Zhang WJ, Yang L, Jie Q
Bone research 2025 Mar 12;13(1):33
Bone research 2025 Mar 12;13(1):33
Gastrodin Alleviates Lumbar Intervertebral Disc Degeneration by Suppressing the NF-κB and MAPK Pathways.
Hu H, Xie T
Cell biochemistry and biophysics 2025 Jun;83(2):2009-2021
Cell biochemistry and biophysics 2025 Jun;83(2):2009-2021
Macrophage Changes and High-Throughput Sequencing in Aging Mouse Intervertebral Disks.
Wang W, Jiang C, Chen JH, Chen YL, Zhang ZW, Yang ZC, Li J, Li XC
JOR spine 2025 Jun;8(2):e70061
JOR spine 2025 Jun;8(2):e70061
GM@mTG-V microspheres promote NP regeneration by reconstructing IVD biomechanics and inflammatory microenvironment.
Gao R, Zhang Y, Deng B, Zhang J, Liang Z, Wei Z, Xu F, Ding T
Materials today. Bio 2025 Jun;32:101897
Materials today. Bio 2025 Jun;32:101897
Xanthohumol bulk-modified polyurethane for tracheal repair: A 'killing two birds with one stone' strategy for tailorable mechanics and durable anti-inflammatory efficacy.
Zheng S, Xu L, Bo Q, Gao E, Zheng E, Xie L, Zhao B, Yi J, Li Y, Xu Y, Wang Y, Tao B
Materials today. Bio 2025 Jun;32:101831
Materials today. Bio 2025 Jun;32:101831
Bi-phasic integrated silk fibroin/polycaprolactone scaffolds for osteochondral regeneration inspired by the native joint tissue and interface.
Zhang Z, Dong Q, Li Z, Cheng G, Li Z
Materials today. Bio 2025 Jun;32:101737
Materials today. Bio 2025 Jun;32:101737
Enhancing BMSC chondrogenesis with a dynamic viscoelastic hyaluronan hydrogel loaded with kartogenin for cartilage repair.
Li G, Ni R, Shi Z, Mao H, Luo Y, Cao X, Zhang C, Liu Y, Jin Z, Chen J, Fu J, Zhang H, Zhu Y
International journal of biological macromolecules 2025 Jun;312:144042
International journal of biological macromolecules 2025 Jun;312:144042
Senescent cartilage endplate stem cells-derived exosomes induce oxidative stress injury in nucleus pulposus cells and aggravate intervertebral disc degeneration by regulating FOXO3.
Bian Z, Zhai Y, Zhang Y, Wang T, Li H, Ouyang J, Liu C, Wang S, Hu Z, Chang X, Zhang C, Liu M, Li C
Free radical biology & medicine 2025 Jun;233:39-54
Free radical biology & medicine 2025 Jun;233:39-54
Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence.
Gan X, Li J, Jiang Y, Wang X, Zeng Y, Chen X, Huang H, Min J, Li G, Nie M, Kang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156697
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156697
Role and mechanism of lncRNA ZEB1-AS1 endogenous competition for miR-365a-3p targeting NRF2 in ferroptosis in articular chondrocytes.
Zhang R, Liu Y, Zang H, He A, Mao Y, Liu W
Journal of molecular histology 2025 Jun 7;56(3):190
Journal of molecular histology 2025 Jun 7;56(3):190
OPTN ameliorates chondrocyte apoptosis in temporomandibular joint osteoarthritis by modulating ER-mitochondria Ca(2+) transfer.
Zhang X, Liu H, Shi Y, Liu Z, Wang Y, Chen S, Yan X, Xu R, Ma J, Chen Q, Guo S
International immunopharmacology 2025 Jun 5;157:114796
International immunopharmacology 2025 Jun 5;157:114796
Unveiling the mechanisms of mechanical loading-induced knee osteoarthritis through transcriptomics.
Wu Y, Li A, Sun N, Jiang Z, Li Y, Zhou Z, Li X, Zhao D, Leng X, Dong H
International immunopharmacology 2025 Jun 5;157:114785
International immunopharmacology 2025 Jun 5;157:114785
RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats' intervertebral disc degeneration.
Chen W, Li D, Chen L, Fei J, Bian M, Zeng Q, Jiang Z, Wu J
Arthritis research & therapy 2025 Jun 19;27(1):128
Arthritis research & therapy 2025 Jun 19;27(1):128
Modulating systemic anti-inflammatory response mitigates osteoarthritis progression and associated pain after low-dose radiotherapy.
Ma G, Yang Y, Li S, Li L, Meng X, Rong Y, Tang M, Cheng Q, Guo H, Li Q, Jin X
International immunopharmacology 2025 Jun 17;158:114815
International immunopharmacology 2025 Jun 17;158:114815
MXene-Based Cartilage-Adhesive Microspheres for Photothermal-Controlled Hydrophobic Drug Release and Mesenchymal Stem Cell Delivery in Osteoarthritis.
Chen F, Wang W, Zhao H, Zhang Z, Pang N, Tang Y, Wang T, Liu C, Huang Z, Mou F, Yu C, Zhang H
ACS nano 2025 Jun 10;19(22):20502-20515
ACS nano 2025 Jun 10;19(22):20502-20515
Engineering a stem cell-embedded bilayer hydrogel with biomimetic collagen mineralization for tendon-bone interface healing.
Lei T, Zhang T, Fang T, Han J, Gu C, Liao Y, Fei Y, Luo J, Liu H, Wu Y, Shen W, Chen X, Yin Z, Wang J
Bioactive materials 2025 Jul;49:207-217
Bioactive materials 2025 Jul;49:207-217
Spatiotemporally Programming Microenvironment to Recapitulate Endochondral Ossification via Greenhouse-Inspired Bionic Niche.
Liu X, Zhao Y, Wu X, Zhou Y, Liu Y, Wang S, Zhang Y, Yang H, Song F, Huang C
Advanced materials (Deerfield Beach, Fla.) 2025 Jul;37(28):e2504057
Advanced materials (Deerfield Beach, Fla.) 2025 Jul;37(28):e2504057
Blocking the LRH-1/LCN2 axis by ML-180, an LRH-1 inverse agonist, ameliorates osteoarthritis via inhibiting the MAPK pathway.
Li J, Zhang Y, Gan X, Li J, Xia G, He L, Xia C, Zhang W, Akhtar Ali K, Zhu M, Huang H
Biochemical pharmacology 2025 Jul;237:116922
Biochemical pharmacology 2025 Jul;237:116922
Phellodendrine chloride alleviates gouty arthritis through IL-6/STAT3 signaling pathway.
Qin YY, Qin ZY, Liang T, Qin DE, Hua SY, Tan MH, Guo S, Yang F, Shi L, Yu Y, Zhang GJ
Immunobiology 2025 Jul;230(4):152918
Immunobiology 2025 Jul;230(4):152918
Mechanical Load-Induced Upregulation of Talin2 through Non-Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis.
Huang Y, Sun H, Chen H, Wang X, Zhao J, Jiao Y, Zhou H, Cai H, Dai J, Huang X, Chen W, Shen J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(25):e2501046
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(25):e2501046
Dihydromyricetin attenuates intervertebral disc degeneration by inhibiting NLRP3 inflammasome activation via the Keap1/Nrf2/HO-1 pathway.
Hong H, Guo D, Xia T, Zhang Y
European journal of pharmacology 2025 Jul 5;998:177501
European journal of pharmacology 2025 Jul 5;998:177501
Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis.
Fu Y, Hou J, Yang Q, Lin Y, Rui N, Wang J, Wu H, Yu B
Journal of nanobiotechnology 2025 Jul 5;23(1):486
Journal of nanobiotechnology 2025 Jul 5;23(1):486
Periplocin targets LRP4 to regulate metabolic homeostasis and anti-inflammation for the treatment of IVDD.
Liu Z, Qiao F, Liu D, Kong X, Liu K, Gu H, Zhang Y, Meng Q, Cheng L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156885
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156885
Genetically engineered chondrocyte-mimetic nanoplatform attenuates osteoarthritis by blocking IL-1β and restoring sirtuin-3.
Deng C, Yu L, Zhao X, Chen Y, Mei J, Wei J, Chen X, Lei G, Zeng C
Science advances 2025 Jul 25;11(30):eadv4238
Science advances 2025 Jul 25;11(30):eadv4238
Antler base (Cervus nippon Temminck) peptides modulate the NLRP3 inflammatory pyroptosis and Nrf2/HO-1/NQO1 signaling pathways to ameliorate osteoarthritis: a structural and mechanistic study.
Sun S, Qiu H, Wang C, Zhang K, Zhao H, Zhao H, Shen Y, Wang Y, Zhang Y
Journal of ethnopharmacology 2025 Jul 24;351:120149
Journal of ethnopharmacology 2025 Jul 24;351:120149
Ameliorating Myocardial Infarction by Concurrent Pyroptosis Suppression and On-Demand Oxygen Production via Functionalized Nanocarrier.
Zhu W, Lu Y, Zong B, Chen Z, Ma Y, Wang H, Cao P, Han B
ACS applied materials & interfaces 2025 Jul 23;17(29):41626-41636
ACS applied materials & interfaces 2025 Jul 23;17(29):41626-41636
Hydrogel Enhanced Organoid Multidirectional Differentiation via Yap/Tead4 Mechanotransduction for Accelerated Tissue Regeneration.
Luo P, Cheng Y, Luo Y, Zhang N, Cao J, Wang H, Jiang X, Wang Q, Wu X, Liu Y, Mao J, Zhou X, Nie JJ, Chen D
ACS applied materials & interfaces 2025 Jul 2;17(26):37601-37616
ACS applied materials & interfaces 2025 Jul 2;17(26):37601-37616
Blocking calcium-MYC regulatory axis inhibits early dedifferentiation of chondrocytes and contributes to cartilage regeneration.
Wu X, Fu Y, Ma J, Wang H, Li C, Zhu Y, Wang Q, Guo X, Zhang T, He A
Stem cell research & therapy 2025 Jul 15;16(1):372
Stem cell research & therapy 2025 Jul 15;16(1):372
Garlic-derived Exosomes Alleviate Osteoarthritis Through Inhibiting the MAPK Signaling Pathway.
Liu Y, Nie M, Li X, Wang H, Ren S, Zou D, Liu J, Li R
Applied biochemistry and biotechnology 2025 Jan;197(1):518-533
Applied biochemistry and biotechnology 2025 Jan;197(1):518-533
Cell-free osteoarthritis treatment with dual-engineered chondrocyte-targeted extracellular vesicles derived from mechanical loading primed mesenchymal stem cells.
Wang P, Zhao H, Chen W, Guo Y, Zhang S, Xing X, Yang S, Wang F, Wang J, Shao Z, Zhang Y
Journal of tissue engineering 2025 Jan-Dec;16:20417314241312563
Journal of tissue engineering 2025 Jan-Dec;16:20417314241312563
circ_0075048 silencing regulates LCP1 to improve IL-1β-induced chondrocyte injury by binding with miR-663b.
Zhang P, Pei R, Shen Q
Journal of orthopaedic surgery and research 2025 Jan 9;20(1):24
Journal of orthopaedic surgery and research 2025 Jan 9;20(1):24
Enhanced Chondrogenic Potential and Osteoarthritis Treatment Using Cyaonoside A-Induced MSC Delivered via a Hyaluronic Acid-Based Hydrogel System.
An X, Zhou Q, Sheng S, Deng A, Liu H, Wang X, Zhang Q, Jing Y, Xu K, He C, Zhao RC, Su J
Aging and disease 2025 Jan 29;17(1):466-482
Aging and disease 2025 Jan 29;17(1):466-482
Integrated analysis of bioinformatics, mendelian randomization, and experimental validation reveals novel diagnostic and therapeutic targets for osteoarthritis: progesterone as a potential therapeutic agent.
Weng Z, Wang C, Liu B, Yang Y, Zhang Y, Zhang C
Journal of orthopaedic surgery and research 2025 Jan 23;20(1):85
Journal of orthopaedic surgery and research 2025 Jan 23;20(1):85
Quercetin Alleviates Hyperglycemic-Generated Endoplasmic Reticulum Stress-Contacted Apoptosis of Rat Nucleus Pulposus Cells.
Yu Z, Wang X, Hu Y, Wang X, Zhu Z, Xu X, Wang Y, Zhang A
Balkan medical journal 2025 Jan 2;42(1):27-36
Balkan medical journal 2025 Jan 2;42(1):27-36
Osteoarthritis-like changes in rat temporomandibular joint induced by unilateral anterior large overjet treatment.
Xie X, Chao R, Mao Y, Wan T, Wang Y, Zhu Y, Xu W, Chen X, Wang Y, Ma Z, Zhang S
Scientific reports 2025 Jan 10;15(1):1646
Scientific reports 2025 Jan 10;15(1):1646
RICTOR-mediated activation of AKT/mTOR signaling and autophagy inhibition promote osteoarthritis.
Xu J, Wang G, Hou Y, Sun K, Zheng Z, Guo Z, Hou L, Zhang X, Ruan Z, Ye Y, Guo F
International immunopharmacology 2025 Jan 10;144:113681
International immunopharmacology 2025 Jan 10;144:113681
Duhuo Jisheng Decoction in reduction of inflammatory response via Transforming growth factor-β/Smad signaling pathway for repairing rabbit articular cartilage Injury: A Randomized Controlled Trial.
Ye C, Yang Z, Li P, Lu Y, Lyu T, Liu Y, Zhou X, Zhao P, Chen J
International immunopharmacology 2025 Jan 10;144:113646
International immunopharmacology 2025 Jan 10;144:113646
Injectable tissue-engineered human cartilage matrix composite fibrin glue for regeneration of articular cartilage defects.
Wang C, Yao H, Shi J, Zhang Z, Cong B, Wu Z, Shang X, Hu X, Yang J, Sun H, Gu Z, Cheng G, Chong H, Wang DA, Zhao Y
Biomaterials advances 2025 Feb;167:214095
Biomaterials advances 2025 Feb;167:214095
Mechanosensitive lncRNA H19 promotes chondrocyte autophagy, but not pyroptosis, by targeting miR-148a in post-traumatic osteoarthritis.
Zhou X, Cao H, Liao T, Hua W, Zhao R, Wang D, Deng H, Yang Y, Liu S, Ni G
Non-coding RNA research 2025 Feb;10:163-176
Non-coding RNA research 2025 Feb;10:163-176
Betaine enhances SCAPs chondrogenic differentiation and promotes cartilage repair in TMJOA through WDR81.
Wang M, Wu Z, Zheng X, Huang Y, Jin Y, Song J, Lei W, Liu H, Yu R, Yang H, Gao R
Stem cell research & therapy 2025 Feb 7;16(1):55
Stem cell research & therapy 2025 Feb 7;16(1):55
Blocking the CCL5/CCL7-CCR1 axis regulates macrophage polarization through NF-κB pathway to alleviate the progression of osteoarthritis.
Xu H, He Y, Chen S, Meng C, Liu Q, Huang XJ, You HB
International immunopharmacology 2025 Feb 6;147:114027
International immunopharmacology 2025 Feb 6;147:114027
Ferristatin II protects nucleus pulposus against degeneration through inhibiting ferroptosis and activating HIF-1α pathway mediated mitophagy.
Su C, Jing X, Liu X, Shao Y, Zheng Y, Liu X, Cui X
International immunopharmacology 2025 Feb 6;147:113895
International immunopharmacology 2025 Feb 6;147:113895
Remodeling the Proinflammatory Microenvironment in Osteoarthritis through Interleukin-1 Beta Tailored Exosome Cargo for Inflammatory Regulation and Cartilage Regeneration.
Chen M, Liu Y, Cao Y, Zhao C, Liu Q, Li N, Liu Y, Cui X, Liu P, Liang J, Fan Y, Wang Q, Zhang X
ACS nano 2025 Feb 4;19(4):4924-4941
ACS nano 2025 Feb 4;19(4):4924-4941
Revolutionizing the treatment of intervertebral disc degeneration: an approach based on molecular typing.
Chen S, Zhang W, Liu Y, Huang R, Zhou X, Wei X
Journal of translational medicine 2025 Feb 25;23(1):227
Journal of translational medicine 2025 Feb 25;23(1):227
Unbalanced occlusal loading elicited remodeling responses in growing rat temporomandibular joints and Notch1/Hes1 signaling pathway expression.
Xiao M, Yue Q, Qin Z, Hang X, Chen X, Ni S
BMC oral health 2025 Feb 19;25(1):267
BMC oral health 2025 Feb 19;25(1):267
Matrix stiffness regulates nucleus pulposus cell glycolysis by MRTF-A-dependent mechanotransduction.
Xu H, Wei K, Ni J, Deng X, Wang Y, Xiang T, Song F, Wang Q, Niu Y, Jiang F, Wang J, Sheng L, Dai J
Bone research 2025 Feb 14;13(1):23
Bone research 2025 Feb 14;13(1):23
PIEZO1-Primary Cilia Axis Mediates Compressive Stress-Induced Growth Plate Degeneration and Ossification in Adolescent Idiopathic Scoliosis.
Chen F, Chen S, Peng F, Du Y, Li J, Fan Y, Cui Z, Gu G, Zhang H, Jing X, Dong J, Li T, Xi Y
JOR spine 2025 Dec;8(4):e70133
JOR spine 2025 Dec;8(4):e70133
Sustained Release of Bone Morphogenetic Protein 2/Chitosan-Collagen Scaffold Repairs Rabbit Knee Joint Cartilage Defects.
Song H, Tang D, Wang B, Luo Y, Yan C, Ruan S
Cell biochemistry and function 2025 Dec;43(12):e70143
Cell biochemistry and function 2025 Dec;43(12):e70143
Integrating superlubricative nanomaterials with precision drug delivery for advanced osteoarthritis therapy.
Gan X, Li J, Li S, Wang X, Wang Q, Chen X, Huang Y, Nie M, Kang H, Dai H
Materials today. Bio 2025 Dec;35:102359
Materials today. Bio 2025 Dec;35:102359
Bottom-up engineering of the nucleus pulposus using a photocrosslinkable decellularized matrix hydrogel attenuates inflammaging and enhances microtissue-mediated regeneration.
Li X, Li X, Zhou D, Xu Y, Sun B, Hu Y, Zhu Y, Hu J, Pang Z, Zhao C, Gao Y, Long Y, Li P, Zhou Q, Wang Y
Materials today. Bio 2025 Dec;35:102347
Materials today. Bio 2025 Dec;35:102347
Photothermal-triggered NO-releasing nanofiber membrane mitigates intervertebral disc degeneration via inflammation inhibition and matrix stabilization.
Huang G, Xie J, Chen J, Zhao J, Wang P, Zhang J, Xu P, Li Y, Chen X, Miao X, Xiong W, Cheng X
Materials today. Bio 2025 Dec;35:102287
Materials today. Bio 2025 Dec;35:102287
Astragalus Polysaccharide Enhances O-GlcNAcylation Through OGT to Improve Intervertebral Disc Degeneration in Rats.
Tan H, Fang C, Tan Y, Wang Z, Zhou Y, Li X
Journal of cellular and molecular medicine 2025 Dec;29(23):e70940
Journal of cellular and molecular medicine 2025 Dec;29(23):e70940
Theaflavin reduces Achilles tendon heterotopic ossification in mice through the TGF-β/Smad signaling pathway.
Li Y, Li C, Zhang W, Le S, Zhou J, Luo B, Xie P, Yan B
Biochemical pharmacology 2025 Dec;242(Pt 4):117387
Biochemical pharmacology 2025 Dec;242(Pt 4):117387
Ethyl gallate suppresses ferroptosis and alleviates intervertebral disc degeneration through targeting AKT1.
Qiu J, Liu X, Li H, Zhou X, Zhang Y, Chen Z, Li K, Wu Y, Zhang X, Zhou Y, Tian N
Biochemical pharmacology 2025 Dec;242(Pt 2):117335
Biochemical pharmacology 2025 Dec;242(Pt 2):117335
Targeting neuregulin-1 in cartilage homeostasis restoration: Kaempferol-3-o-rutinoside as a novel treatment for osteoarthritis.
Sheng Y, Li S, Wang X, Cui P, Wang Y, Wang Y, Zhang Y, Wang Q, Wang C, Tao J, Wu C, Jiang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Dec;149:157562
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Dec;149:157562
TLR4-IN-C34 attenuates the progression of osteoarthritis through inhibiting inflammation, angiogenesis and pain.
Wei K, Zou Y, Xu H, Liu H, Liu C
Cellular signalling 2025 Dec;136:112084
Cellular signalling 2025 Dec;136:112084
Serum miR-576-5p as a novel diagnostic biomarker and therapeutic target for osteoarthritis via targeting KLF10-mediated chondrocyte dysfunction.
Weng M, Yang Z, Feng X
BMC musculoskeletal disorders 2025 Dec 9;26(1):1088
BMC musculoskeletal disorders 2025 Dec 9;26(1):1088
SMARCA5 Cooperates With RSF1 to Promote Pathological Glycolysis and Chondrocyte Dysfunction in Osteoarthritis Through ATPase-Dependent Chromatin Regulation.
Xu J, Tang C, Shen H, Ni B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 31;39(24):e71324
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 31;39(24):e71324
RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA.
Zhang X, Jiang Q, Deng W, Tang H, Liu Y, Xu Z, Guo K, Liu N, Wang H, Cui T, Wang F, Qiu J
Arthritis research & therapy 2025 Dec 18;28(1):16
Arthritis research & therapy 2025 Dec 18;28(1):16
Mechanism of lidocaine-induced ROS generation triggering DNA double-strand breaks and promoting intervertebral disc cell senescence via the MYC-DUSP1-P53 axis.
Zhou R, Wang X, Jin Y, Chen B, Liu H, Zhao X, Jing D, Zhao B
Free radical biology & medicine 2025 Dec 1;240:457-471
Free radical biology & medicine 2025 Dec 1;240:457-471
Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1.
Kuang B, Geng N, Yi M, Zeng Q, Fan M, Xian M, Deng L, Chen C, Pan Y, Kuang L, Luo F, Xie Y, Liu C, Deng Z, Nie M, Du Y, Guo F
Journal of advanced research 2025 Aug;74:493-511
Journal of advanced research 2025 Aug;74:493-511
Schistosoma japonicum-Derived Peptide SJMHE1 Attenuates Osteoarthritis by Promoting Synovial M2 Macrophage Polarisation.
Zhu W, Jiang Y, Wang S, Wang X, Zhang Q, Fan W
Parasite immunology 2025 Aug;47(8):e70018
Parasite immunology 2025 Aug;47(8):e70018
Deliver CEBPE via cartilage targeting Lipid nanoparticle to block CEBPE-LTF-STAT3 positive feedback loop for efficient treatment of cartilage endplate degeneration.
Zhao J, Xu P, Li T, Yuan J, Zhao W, Ding R, Yang G, Xie J, Huang G, Peng Z, Miao X, Cheng X
Materials today. Bio 2025 Aug;33:102027
Materials today. Bio 2025 Aug;33:102027
Highly biomimetic three-layer mineralized collagen scaffold featuring a wood-reinforced subchondral bone region for gradient chondrogenic-osteogenic differentiation of bone marrow-derived mesenchymal stem cells.
Wang L, Chen X, Wang X, Chen H, Yang X, Xiao J
International journal of biological macromolecules 2025 Aug;320(Pt 1):145754
International journal of biological macromolecules 2025 Aug;320(Pt 1):145754
Zn(2+)-driven metformin conjugated with siRNA attenuates osteoarthritis progression by inhibiting NF-κB signaling and activating autophagy.
He H, Huang C, Huang H, Lan N, Liu S, Luo Y, Zheng L, Liu G, Qin Z, Zhao J
Biomaterials 2025 Aug;319:123210
Biomaterials 2025 Aug;319:123210
Tissue-specific composite hydrogel-loaded BMSCs inhibit apoptosis and promote meniscal repair.
Meng J, Deng L, Lu J, Jiang C, Wang H, Yao J
Biomaterials advances 2025 Aug;173:214258
Biomaterials advances 2025 Aug;173:214258
Cold exposure promotes the progression of osteoarthritis through downregulating APOE in cartilage.
Zhang Y, Fu M, Zhou C, Wang X, Jiang Z, Jiang C, Guo S, Pang Z, Wang C, Yu T, An S, Wang X, Wang Z
EMBO molecular medicine 2025 Aug;17(8):2137-2162
EMBO molecular medicine 2025 Aug;17(8):2137-2162
USP5-Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation.
Shi P, Gao H, Cheng Z, Wu W, Zhang A, Chen X, Wu W, Zhang Y
Journal of extracellular vesicles 2025 Aug;14(8):e70148
Journal of extracellular vesicles 2025 Aug;14(8):e70148
β-Mangostin Attenuates TET2-Mediated DNA Demethylation of Prkcg in the Prevention of Intervertebral Disc Degeneration.
Kong X, Gu H, Zhang Y, Meng Q, Li Q, Song K, Li Y, Liu K, Liu Z, Hu R, Zhai H, Li T, Ling Z, Wei Z, Wei F, Cheng L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(32):e05077
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(32):e05077
DNA Origami-Based CD44-Targeted Therapy Silences Stat3 Enhances Cartilage Regeneration and Alleviates Osteoarthritis Progression.
Lv Q, Zhao X, Teng S, Jin X, Zhou Y, Sun Y, Pei H, Yan Z, Ma C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e03939
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e03939
Matrix Stiffening-Induced SLIT3 Activation in Chondrocytes Drives Cartilage Degradation and Angiogenesis in Temporomandibular Joint Osteoarthritis.
Chen Y, Yuan W, Wang Y, Liu W, Shi J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70936
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70936
A multifaceted strategy for intra- and extracellular nucleic acid regulation to alleviate intervertebral disc degeneration.
Zhao L, Liang K, Cheng W, Zhou X, Yang L, Mao X, Qi W, Jin H, Zhang W, Pan H, Wang D
Nature communications 2025 Aug 26;16(1):7936
Nature communications 2025 Aug 26;16(1):7936
β-Sitosterol preconditioning enhances the resistance of BMSCs and chondrocyte to oxidative stress and promotes cartilage repair in osteoarthritis.
Liu C, Wang X, Zhang Y, Ge H, Chang Q, Zhou Z
Stem cell research & therapy 2025 Aug 26;16(1):460
Stem cell research & therapy 2025 Aug 26;16(1):460
HIF-1α regulates the proliferation and differentiation of mouse cranial base sphenoid-occipital synchondrosis chondrocytes via PI3K/Akt signaling.
Liang C, Yin S, Yang Z, Wang Y, Hu J, Gao G
Scientific reports 2025 Aug 25;15(1):31240
Scientific reports 2025 Aug 25;15(1):31240
The miR-6779/XIAP axis alleviates IL-1β-induced chondrocyte senescence and extracellular matrix loss in osteoarthritis.
Li Z, Dai A, Fang X, Tang K, Chen K, Gao P, Su J, Chen X, Yang S, Deng Z, Li L
Animal models and experimental medicine 2025 Apr;8(4):662-673
Animal models and experimental medicine 2025 Apr;8(4):662-673
Synergizing adaptive immunity and regenerative signals to enhance osteochondral defects repair.
Lin C, Ying C, Xu Y, Zou Y, Chen R, Xu K, Ji X, Cao Q, Weng J, Jiang L, Ye C, Xu K, He Y, Li W, Wu L, Ran J, Xiong Y, Yu X, Bao J
Bioactive materials 2025 Apr;46:242-258
Bioactive materials 2025 Apr;46:242-258
sLithospermic acid etched ZIF-8 nanoparticles delays osteoarthritis progression by inhibiting inflammatory signaling pathways and rescuing mitochondrial damage.
Zhang Y, Lou Q, Lian H, Yang R, Cui R, Wang L, Ma B, Hou L, Jin L, Teng W
Materials today. Bio 2025 Apr;31:101589
Materials today. Bio 2025 Apr;31:101589
tsRNA-12391-Modified Adipose Mesenchymal Stem Cell-Derived Exosomes Mitigate Cartilage Degeneration in Osteoarthritis by Enhancing Mitophagy.
Shi J, Zhao G, Wang S, Wei Y, Wu J, Huang G, Chen J, Xia J
Biotechnology journal 2025 Apr;20(4):e202400611
Biotechnology journal 2025 Apr;20(4):e202400611
Inflammation-modulating elastic decellularized extracellular matrix scaffold promotes meniscus regeneration.
Ding Y, Huang M, Cai P, Yu X, Cui J, Sun B, Mo X, Lu C, Chen J, Wu J
Acta biomaterialia 2025 Apr;196:93-108
Acta biomaterialia 2025 Apr;196:93-108
Cerium Dioxide Nanoparticles-Based Inspector Enhances Mitochondrial Quality Control to Maintain Chondrocyte Homeostasis in Osteoarthritis Therapy.
Chen L, Yang J, Cai Z, Huang Y, Zhang Q, Zhou C, Wang J, Huang W, Cui W, Hu N
Advanced healthcare materials 2025 Apr;14(10):e2405069
Advanced healthcare materials 2025 Apr;14(10):e2405069
Palmatine activation of TFEB enhances autophagy and alleviates endoplasmic reticulum stress in intervertebral disc degeneration.
Yu H, Chen K, Li X, Liang J, Jin Y, Bao Y, Chen H, Gou Y, Lu K, Wu L, Lin Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156431
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156431
3-D Sustained-Release Culture Carrier Alleviates Rat Intervertebral Disc Degeneration by Targeting STING in Transplanted Skeletal Stem Cells.
Luo L, Zhang S, Gong J, Zhang J, Xie P, Yin J, Zhang M, Zhang C, Chen H, Liu Y, Ni B, Li C, Tian Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2410151
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2410151
Enhanced Ear Cartilage Regeneration with Dual-Network LT-GelMA/F127DA Hydrogel Featuring Nanomicelle Integration.
Liu B, Jiang Y, Tian Y, Li T, Zhang D
ACS omega 2025 Apr 8;10(13):13570-13582
ACS omega 2025 Apr 8;10(13):13570-13582
Fullerol Initiates Stem Cell-Nanomaterials Interactions for Enhanced Tissue Regeneration via Clathrin-Mediated Endocytosis and Nuclear Factor Erythroid 2-Related Factor 2 Signaling.
Liu H, Zhu Y, Chen W, Sheng R, Liu C, Sun Y, Liu J, Wang M, Lu J, Chen J, Zhang W
ACS applied materials & interfaces 2025 Apr 30;17(17):25011-25034
ACS applied materials & interfaces 2025 Apr 30;17(17):25011-25034
Microneedle delivery of CAR-M-like engineered macrophages alleviates intervertebral disc degeneration through enhanced efferocytosis capacity.
Zhou X, Zhu D, Wu D, Li G, Liang H, Zhang W, Wu Y, Xu H, Zhang Z, Tong B, Song Y, Wang K, Feng X, Lei J, Wang H, Zhang X, Ma L, Chen Y, Wei J, Ou Z, Peng S, Wu X, Tan L, Wang B, Yang C
Cell reports. Medicine 2025 Apr 15;6(4):102079
Cell reports. Medicine 2025 Apr 15;6(4):102079
Quercetin-primed MSC exosomes synergistically attenuate osteoarthritis progression.
Lu M, Lou A, Gao J, Li S, He L, Fan W, Zhao L
Journal of orthopaedic surgery and research 2025 Apr 15;20(1):373
Journal of orthopaedic surgery and research 2025 Apr 15;20(1):373
Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes.
Wang W, Cheng Z, Yu M, Liu K, Duan H, Zhang Y, Huang X, Li M, Li C, Hu Y, Luo Z, Liu M
Nature communications 2025 Apr 1;16(1):3131
Nature communications 2025 Apr 1;16(1):3131
Platelet-rich plasma ameliorates cartilage degradation in rat models of osteoarthritis via the OPG/RANKL/RANK system.
Wu Q, Yao X, Shan N, Cai Y, Fan Y
Folia histochemica et cytobiologica 2024;62(3):154-164
Folia histochemica et cytobiologica 2024;62(3):154-164
Hyaluronic Acid-Based Microparticles with Lubrication and Anti-Inflammation for Alleviating Temporomandibular Joint Osteoarthritis.
Liu L, He G, Li Y, Xian Y, He G, Hong Y, Zhang C, Wu D
Biomaterials research 2024;28:0073
Biomaterials research 2024;28:0073
The role and underlying mechanism of dental pulp stem cell-derived exosomal miR-31 in the treatment of osteoarthritis by targeting mTOR to enhance chondrocyte autophagy levels.
Zhao G, Lyu J, Huang X, Huang G, Chen F, Wei Y, Wang S, Xia J, Chen J, Shi J
Archives of medical science : AMS 2024;20(5):1680-1694
Archives of medical science : AMS 2024;20(5):1680-1694
Mume Fructus reduces interleukin-1 beta-induced cartilage degradation via MAPK downregulation in rat articular chondrocytes.
Park DR, Choi BR, Yeo C, Yoon JE, Hong EY, Baek SH, Lee YJ, Ha IH
PloS one 2024;19(5):e0302906
PloS one 2024;19(5):e0302906
Protective effects of ectoine on articular chondrocytes and cartilage in rats for treating osteoarthritis.
Li P, Huang Y, Miao L, Zhu Z, Shi Z
PloS one 2024;19(2):e0299351
PloS one 2024;19(2):e0299351
The Therapeutic Potential of Pristimerin in Osteoarthritis: Mechanistic Insights from in vitro and in vivo Studies.
Yin L, Fan Y, Zhong X, Meng X, He Z, Hong Z, Chen J, Zhang Q, Kong M, Wang J, Tong Y, Bi Q
Drug design, development and therapy 2024;18:5445-5459
Drug design, development and therapy 2024;18:5445-5459
Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Radix Rehmanniae Praeparata - Angelica Sinensis - Radix Achyranthis Bidentatae in Treating Knee Osteoarthritis.
Liu L, Zhang B, Zhou Z, Yang J, Li A, Wu Y, Peng Z, Li X, Liu Z, Leng X, Zhao C, Dong H, Zhao W
Drug design, development and therapy 2024;18:1583-1602
Drug design, development and therapy 2024;18:1583-1602
"Dictionary of immune responses" reveals the critical role of monocytes and the core target IRF7 in intervertebral disc degeneration.
Xu P, Li K, Yuan J, Zhao J, Pan H, Pan C, Xiong W, Tan J, Li T, Huang G, Chen X, Miao X, He D, Cheng X
Frontiers in immunology 2024;15:1465126
Frontiers in immunology 2024;15:1465126
Role of integrin β1 and tenascin C mediate TGF-SMAD2/3 signaling in chondrogenic differentiation of BMSCs induced by type I collagen hydrogel.
Huang Y, Sun M, Lu Z, Zhong Q, Tan M, Wei Q, Zheng L
Regenerative biomaterials 2024;11:rbae017
Regenerative biomaterials 2024;11:rbae017
Melatonin Alleviates Osteoarthritis by Regulating NADPH Oxidase 4-Induced Ferroptosis and Mitigating Mitochondrial Dysfunction.
Wang Q, Qi B, Shi S, Jiang W, Li D, Jiang X, Yi C
Journal of pineal research 2024 Sep;76(6):e12992
Journal of pineal research 2024 Sep;76(6):e12992
Memantine attenuates the development of osteoarthritis by blocking NMDA receptor mediated calcium overload and chondrocyte senescence.
Cheng Q, He K, Zhu J, Li X, Wu X, Zeng C, Lei G, Wang N, Li H, Wei J
Journal of orthopaedic translation 2024 Sep;48:204-216
Journal of orthopaedic translation 2024 Sep;48:204-216
Injectable Inflammation-Responsive Hydrogels for Microenvironmental Regulation of Intervertebral Disc Degeneration.
Liu L, Wang W, Huang L, Xian Y, Ma W, Zhao L, Li Y, Zheng Z, Liu H, Wu D
Advanced healthcare materials 2024 Sep;13(22):e2400717
Advanced healthcare materials 2024 Sep;13(22):e2400717
Suppression of YAP Ameliorates Cartilage Degeneration in Ankle Osteoarthritis via Modulation of the Wnt/β-Catenin Signaling Pathway.
Fan Z, Zhao X, Ma J, Zhan H, Ma X
Calcified tissue international 2024 Sep;115(3):283-297
Calcified tissue international 2024 Sep;115(3):283-297
Isoquercetin Ameliorates Osteoarthritis via Nrf2/NF-κB Axis: An In Vitro and In Vivo Study.
Yu H, Lou J, Ni L, Yan M, Zhu K, Mao S, Zhu J
Chemical biology & drug design 2024 Sep;104(3):e14620
Chemical biology & drug design 2024 Sep;104(3):e14620
10-hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence in male mice preclinically.
Geng N, Fan M, Kuang B, Zhang F, Xian M, Deng L, Chen C, Pan Y, Chen J, Feng N, Liang L, Ye Y, Liu K, Li X, Du Y, Guo F
Nature communications 2024 Sep 4;15(1):7712
Nature communications 2024 Sep 4;15(1):7712
Deferoxamine alleviates chondrocyte senescence and osteoarthritis progression by maintaining iron homeostasis.
Guo Z, Lin Y, Liu H, Guo J, Hou L, Zhang X, Xu J, Ruan Z, Li M, Sun K, Guo F
International immunopharmacology 2024 Sep 30;139:112619
International immunopharmacology 2024 Sep 30;139:112619
Omega-3 fatty acids protect cartilage from acute injurie by reducing the mechanical sensitivity of chondrocytes.
Chen F, Zhang Z, Wang W, Liu C, Huang Z, Yu C, Jia Z, Zhang H
Journal of orthopaedic surgery and research 2024 Sep 28;19(1):591
Journal of orthopaedic surgery and research 2024 Sep 28;19(1):591
Macrophage membrane-camouflaged biomimetic nanoparticles for rheumatoid arthritis treatment via modulating macrophage polarization.
Zhou R, Xue S, Cheng Y, Chen Y, Wang Y, Xing J, Liu H, Xu Y, Lin Y, Pei Z, Wei X, Ding J, Li S, Wang K, Yao F, Zhao Y, Ding C, Hu W
Journal of nanobiotechnology 2024 Sep 19;22(1):578
Journal of nanobiotechnology 2024 Sep 19;22(1):578
Lubricin-Inspired Nanozymes Reconstruct Cartilage Lubrication System with an "In-Out" Strategy.
Du C, Chen Z, Liu S, Liu J, Zhan J, Zou J, Liao J, Huang W, Lei Y
Small methods 2024 Oct;8(10):e2400757
Small methods 2024 Oct;8(10):e2400757
Ellagic acid improves osteoarthritis by inhibiting PGE2 production in M1 macrophages via targeting PTGS2.
Zhang C, Li X, Wen P, Li Y
Clinical and experimental pharmacology & physiology 2024 Oct;51(10):e13918
Clinical and experimental pharmacology & physiology 2024 Oct;51(10):e13918
Sequential Targeted Enzyme-Instructed Self-Assembly Supramolecular Nanofibers to Attenuate Intervertebral Disc Degeneration.
Liu Y, Sun X, Wang L, Dou Y, Tian Y, Yu T, Zhang Y, Zhao Q, Lu J, Feng Y, Wang J, Liu X, Shang Y, Li C, Yang Q
Advanced materials (Deerfield Beach, Fla.) 2024 Oct;36(41):e2408678
Advanced materials (Deerfield Beach, Fla.) 2024 Oct;36(41):e2408678
Enhancing long-segmental tracheal restoration: A self-repairing hydrogel loaded with chondrocytokines for sutureless anastomosis and cartilage regeneration.
Guo L, Liu X, Wang Y, Yi J, Li J, Xu Y, Cai K, Dai W, Feng Q, Tao B
Materials today. Bio 2024 Oct;28:101208
Materials today. Bio 2024 Oct;28:101208
Angelica sinensis polysaccharide facilitates chondrogenic differentiation of adipose-derived stem cells via MDK-PI3K/AKT signaling cascade.
Li Y, Yang Y, Zhu L, Xie S, Guo L, Zhang Z, Zhe C, Li W, Liu F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117349
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117349
ROS-Responsive Injectable Hydrogel Loaded with SLC7A11-modRNA Inhibits Ferroptosis and Mitigates Intervertebral Disc Degeneration in Rats.
Gao T, Xu G, Ma T, Lu X, Chen K, Luo H, Chen G, Song J, Ma X, Fu W, Zheng C, Xia X, Jiang J
Advanced healthcare materials 2024 Oct;13(27):e2401103
Advanced healthcare materials 2024 Oct;13(27):e2401103
IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2.
Deng Z, Long D, Li C, Liu H, Li W, Zhong Y, Mo X, Li R, Yang Z, Kang Y, Mao G
Bone research 2024 Oct 28;12(1):63
Bone research 2024 Oct 28;12(1):63
Bioenergetic-active exosomes for cartilage regeneration and homeostasis maintenance.
Liu X, Jiang S, Jiang T, Lan Z, Zhang X, Zhong Z, Wu X, Xu C, Du Y, Zhang S
Science advances 2024 Oct 18;10(42):eadp7872
Science advances 2024 Oct 18;10(42):eadp7872
Cyclic negative pressure promotes chondrocyte growth: Association of IGF-2 with EGR-1.
Li X, Huang L, Liu B, Zhang Z, Zhou G, Guo Z, Song J, Wang X
Biomolecules & biomedicine 2024 Oct 17;24(6):1761-1775
Biomolecules & biomedicine 2024 Oct 17;24(6):1761-1775
TDP-43 ameliorates aging-related cartilage degradation through preventing chondrocyte senescence.
Wang L, Zhang J, Liang L, Song Z, Wang P, Ma L, Liao Z, Li N, Yang H, Li S
Experimental gerontology 2024 Oct 1;195:112546
Experimental gerontology 2024 Oct 1;195:112546
KLF2 Inhibits Ferroptosis and Improves Mitochondrial Dysfunction in Chondrocyte Through SIRT1/GPX4 Signaling to Improve Osteoarthritis.
Shi J, Chen L, Wang X, Ma X
Drug development research 2024 Nov;85(7):e70015
Drug development research 2024 Nov;85(7):e70015
An anti-senescence hydrogel with pH-responsive drug release for mitigating intervertebral disc degeneration and low back pain.
Wang W, Liu L, Ma W, Zhao L, Huang L, Zhou D, Fan J, Wang J, Liu H, Wu D, Zheng Z
Bioactive materials 2024 Nov;41:355-370
Bioactive materials 2024 Nov;41:355-370
Polyphenol-modified biomimetic bioadhesives for the therapy of annulus fibrosus defect and nucleus pulposus degeneration after discectomy.
Ju Y, Ma S, Fu M, Wu M, Li Y, Wang Y, Tao M, Lu Z, Guo J
Acta biomaterialia 2024 Nov;189:116-129
Acta biomaterialia 2024 Nov;189:116-129
Anti-Stress and Anti-ROS Effects of MnOx-Functionalized Thermosensitive Nanohydrogel Protect BMSCs for Intervertebral Disc Degeneration Repair.
Wang X, Yu L, Duan J, Chang M, Hao M, Xiang Z, Qiu C, Sun J, Di D, Xia H, Li D, Yuan S, Tian Y, Qiu J, Liu H, Liu X, Sang Y, Wang L
Advanced healthcare materials 2024 Nov;13(29):e2400343
Advanced healthcare materials 2024 Nov;13(29):e2400343
RIP1 inhibition reduces chondrocyte apoptosis through downregulating nuclear factor-kappa B signaling in a mouse osteoarthritis model.
Zhao H, Wang C, Liu B, Weng Z, Shi Y, Zhang C
Molecular biology reports 2024 Nov 8;51(1):1132
Molecular biology reports 2024 Nov 8;51(1):1132
Procyanidin C1 ameliorates acidic pH stress induced nucleus pulposus degeneration through SIRT3/FOXO3-mediated mitochondrial dynamics.
Hua W, Xie L, Dong C, Yang G, Chi S, Xu Z, Yang C, Wang H, Wu X
Journal of translational medicine 2024 Nov 27;22(1):1071
Journal of translational medicine 2024 Nov 27;22(1):1071
Zfp260 choreographs the early stage osteo-lineage commitment of skeletal stem cells.
Weng Y, Feng Y, Li Z, Xu S, Wu D, Huang J, Wang H, Wang Z
Nature communications 2024 Nov 24;15(1):10186
Nature communications 2024 Nov 24;15(1):10186
Systematic analysis of lysine lactylation in nucleus pulposus cells.
Sheng L, Xu H, Wang Y, Ni J, Xiang T, Xu H, Zhou X, Wei K, Dai J
iScience 2024 Nov 15;27(11):111157
iScience 2024 Nov 15;27(11):111157
HIF-2α/TFR1 mediated iron homeostasis disruption aggravates cartilage endplate degeneration through ferroptotic damage and mtDNA release: A new mechanism of intervertebral disc degeneration.
Jing X, Wang W, He X, Liu X, Yang X, Su C, Shao Y, Ge Z, Wang H, Cui X
Journal of orthopaedic translation 2024 May;46:65-78
Journal of orthopaedic translation 2024 May;46:65-78
Exosomes from umbilical cord mesenchymal stem cells ameliorate intervertebral disc degeneration via repairing mitochondrial dysfunction.
Jia S, Yang T, Gao S, Bai L, Zhu Z, Zhao S, Wang Y, Liang X, Li Y, Gao L, Zhang Z, Gao X, Li D, Chen S, Zhang B, Meng C
Journal of orthopaedic translation 2024 May;46:103-115
Journal of orthopaedic translation 2024 May;46:103-115
Development of alginate-collagen interpenetrating network for osteoarthritic cartilage by in situ softening.
Du G, Zhang J, Shuai Q, Li L, Zhang Q, Shi R
International journal of biological macromolecules 2024 May;266(Pt 2):131259
International journal of biological macromolecules 2024 May;266(Pt 2):131259
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.
Dong ZL, Jiao X, Wang ZG, Yuan K, Yang YQ, Wang Y, Li YT, Wang TC, Kan TY, Wang J, Tao HR
Military Medical Research 2024 May 6;11(1):28
Military Medical Research 2024 May 6;11(1):28
Effect of umbilical cord blood-mononuclear cells on knee osteoarthritis in rabbits.
Fu Y, Zhang C, Yang Y, Zhou B, Yang M, Zhu G, Zhu Y
Journal of orthopaedic surgery and research 2024 May 30;19(1):323
Journal of orthopaedic surgery and research 2024 May 30;19(1):323
Genkwanin alleviates intervertebral disc degeneration via regulating ITGA2/PI3K/AKT pathway and inhibiting apoptosis and senescence.
Li M, Yu X, Chen X, Jiang Y, Zeng Y, Ren R, Nie M, Zhang Z, Bao Y, Kang H
International immunopharmacology 2024 May 30;133:112101
International immunopharmacology 2024 May 30;133:112101
Chondroprotective effects of Apolipoprotein D in knee osteoarthritis mice through the PI3K/AKT/mTOR signaling pathway.
Zhang G, Huang C, Wang R, Guo J, Qin Y, Lv S
International immunopharmacology 2024 May 30;133:112005
International immunopharmacology 2024 May 30;133:112005
Targeting the HSP47-collagen axis inhibits brain metastasis by reversing M2 microglial polarization and restoring anti-tumor immunity.
Wang L, Li C, Zhan H, Li S, Zeng K, Xu C, Zou Y, Xie Y, Zhan Z, Yin S, Zeng Y, Chen X, Lv G, Han Z, Zhou D, Zhou D, Yang Y, Zhou A
Cell reports. Medicine 2024 May 21;5(5):101533
Cell reports. Medicine 2024 May 21;5(5):101533
Engineered Exosomes with ATF5-Modified mRNA Loaded in Injectable Thermogels Alleviate Osteoarthritis by Targeting the Mitochondrial Unfolded Protein Response.
Ma T, Xu G, Gao T, Zhao G, Huang G, Shi J, Chen J, Song J, Xia J, Ma X
ACS applied materials & interfaces 2024 May 1;16(17):21383-21399
ACS applied materials & interfaces 2024 May 1;16(17):21383-21399
Inhibition of SAT1 alleviates chondrocyte inflammation and ferroptosis by repressing ALOX15 expression and activating the Nrf2 pathway.
Xu J, Ruan Z, Guo Z, Hou L, Wang G, Zheng Z, Zhang X, Liu H, Sun K, Guo F
Bone & joint research 2024 Mar 7;13(3):110-123
Bone & joint research 2024 Mar 7;13(3):110-123
Peptide-Based Hydrogel Scaffold Facilitates Articular Cartilage Damage Repair.
Chen C, Wu D, Wang Z, Liu L, He J, Li J, Chu B, Wang S, Yu B, Liu W
ACS applied materials & interfaces 2024 Mar 6;16(9):11336-11348
ACS applied materials & interfaces 2024 Mar 6;16(9):11336-11348
SIRT3 alleviates high glucose-induced chondrocyte injury through the promotion of autophagy and suppression of apoptosis in osteoarthritis progression.
Wang X, Liu Z, Deng S, Zhou J, Li X, Huang J, Chen J, Ji C, Deng Y, Hu Y
International immunopharmacology 2024 Mar 30;130:111755
International immunopharmacology 2024 Mar 30;130:111755
Gentiopicroside ameliorates the lipopolysaccharide-induced inflammatory response and hypertrophy in chondrocytes.
Li L, Fan Q, Zhao Y, Zhang Q, Qin G, Li C, Li W
Journal of orthopaedic surgery and research 2024 Mar 25;19(1):198
Journal of orthopaedic surgery and research 2024 Mar 25;19(1):198
Circular RNA CircFOXO3 Functions as a Competitive Endogenous RNA for Acid-Sensing Ion Channel Subunit 1 Mediating Oxeiptosis in Nucleus Pulposus.
Chen X, Song Y, Chen G, Zhang B, Bai Y, Sun C, Fan D, Chen Z
Biomedicines 2024 Mar 18;12(3)
Biomedicines 2024 Mar 18;12(3)
TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis.
Wang W, Ma Z, Feng X, Ren J, Sun S, Shao Y, Zhang W, Yang X, Zhang J, Jing X
Arthritis research & therapy 2024 Mar 16;26(1):71
Arthritis research & therapy 2024 Mar 16;26(1):71
Low-intensity pulsed ultrasound delays the progression of osteoarthritis by regulating the YAP-RIPK1-NF-κB axis and influencing autophagy.
Pan C, Lu F, Hao X, Deng X, Liu J, Sun K, Hou W, Shang X, Chi R, Guo F, Xu T
Journal of translational medicine 2024 Mar 16;22(1):286
Journal of translational medicine 2024 Mar 16;22(1):286
Atractylenolide-III attenuates osteoarthritis by repolarizing macrophages through inactivating TLR4/NF-κB signaling.
Yi G, Zhang R, Li M, Song X, Li S
International immunopharmacology 2024 Mar 10;129:111629
International immunopharmacology 2024 Mar 10;129:111629
Moderate mechanical stress suppresses chondrocyte ferroptosis in osteoarthritis by regulating NF-κB p65/GPX4 signaling pathway.
Han J, Zhan LN, Huang Y, Guo S, Zhou X, Kapilevich L, Wang Z, Ning K, Sun M, Zhang XA
Scientific reports 2024 Mar 1;14(1):5078
Scientific reports 2024 Mar 1;14(1):5078
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy.
Xu T, Zhao H, Li J, Fang X, Wu H, Hu W
JOR spine 2024 Jun;7(2):e1325
JOR spine 2024 Jun;7(2):e1325
Astaxanthin reduces inflammation and promotes a chondrogenic phenotype by upregulating SIRT1 in osteoarthritis.
Qin H, Liu X, Ding Q, Liu H, Ma C, Wei Y, Lv Y, Wang S, Ren Y
The Knee 2024 Jun;48:83-93
The Knee 2024 Jun;48:83-93
A natural hydrogel complex improves intervertebral disc degeneration by correcting fatty acid metabolism and inhibiting nucleus pulposus cell pyroptosis.
Wang D, Zhang L, He D, Zhang Y, Zhao L, Miao Z, Cheng W, Zhu C, Shao Y, Ge G, Zhu H, Jin H, Zhang W, Pan H
Materials today. Bio 2024 Jun;26:101081
Materials today. Bio 2024 Jun;26:101081
A multifunctional nanogel encapsulating layered double hydroxide for enhanced osteoarthritis treatment via protection of chondrocytes and ECM.
Liu C, Sun Y, Li D, Wang F, Wang H, An S, Sun S
Materials today. Bio 2024 Jun;26:101034
Materials today. Bio 2024 Jun;26:101034
Botulinum toxin A attenuates osteoarthritis development via inhibiting chondrocyte ferroptosis through SLC7Al1/GPX4 axis.
Zeng L, Liu Y, Wang Q, Wan H, Meng X, Tu P, Chen H, Luo A, Hu P, Ding X
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167215
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167215
A Novel Role for Protein Tyrosine Phosphatase 1B in Alleviating Chondrocyte Senescence.
Li HM, Che X, Tong Z, Wei W, Teng C
ACS omega 2024 Jun 25;9(25):27017-27029
ACS omega 2024 Jun 25;9(25):27017-27029
α-Ketoglutarate alleviates osteoarthritis by inhibiting ferroptosis via the ETV4/SLC7A11/GPX4 signaling pathway.
He R, Wei Y, Peng Z, Yang J, Zhou Z, Li A, Wu Y, Wang M, Li X, Zhao D, Liu Z, Dong H, Leng X
Cellular & molecular biology letters 2024 Jun 14;29(1):88
Cellular & molecular biology letters 2024 Jun 14;29(1):88
Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis.
Geng N, Xian M, Deng L, Kuang B, Pan Y, Liu K, Ye Y, Fan M, Bai Z, Guo F
Journal of orthopaedic translation 2024 Jul;47:50-62
Journal of orthopaedic translation 2024 Jul;47:50-62
TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes.
Lu R, Qu Y, Wang Z, He Z, Xu S, Cheng P, Lv Z, You H, Guo F, Chen A, Zhang J, Liang S
Journal of orthopaedic translation 2024 Jul;47:207-222
Journal of orthopaedic translation 2024 Jul;47:207-222
MMP13-targeted siRNA-loaded micelles for diagnosis and treatment of posttraumatic osteoarthritis.
Zhou D, Wei Y, Sheng S, Wang M, Lv J, Zhao B, Chen X, Xu K, Bai L, Wu Y, Song P, Cao L, Zhou F, Zhang H, Shi Z, Su J
Bioactive materials 2024 Jul;37:378-392
Bioactive materials 2024 Jul;37:378-392
Activation of Notch Signaling Pathway is involved in Extracellular Matrix Degradation in human induced pluripotent stem cells chondrocytes induced by HT-2 toxin.
Meng P, Liu H, Liu L, Wen Y, Zhang F, Zhang Y, Jia Y, Zhang Y, Zhang F, Guo X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Jul;189:114724
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Jul;189:114724
Acetyl-11-keto-β-boswellic acid restrains the progression of synovitis in osteoarthritis via the Nrf2/HO-1 pathway.
Zhou J, Li X, Han Z, Qian Y, Bai L, Han Q, Gao M, Xue Y, Geng D, Yang X, Hao Y
Acta biochimica et biophysica Sinica 2024 Jul 8;56(11):1644-1658
Acta biochimica et biophysica Sinica 2024 Jul 8;56(11):1644-1658
The regulatory mechanism of cyclic GMP-AMP synthase on inflammatory senescence of nucleus pulposus cell.
Sun R, Wang F, Zhong C, Shi H, Peng X, Gao JW, Wu XT
Journal of orthopaedic surgery and research 2024 Jul 22;19(1):421
Journal of orthopaedic surgery and research 2024 Jul 22;19(1):421
IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte damage in osteoarthritis.
Sun K, Lu F, Hou L, Zhang X, Pan C, Liu H, Zheng Z, Guo Z, Ruan Z, Hou Y, Zhang J, Guo F, Zhu W
Cell communication and signaling : CCS 2024 Jul 18;22(1):366
Cell communication and signaling : CCS 2024 Jul 18;22(1):366
The Combined Intraosseous Administration of Orthobiologics Outperformed Isolated Intra-articular Injections in Alleviating Pain and Cartilage Degeneration in a Rat Model of MIA-Induced Knee Osteoarthritis.
Zhang K, Yu J, Li J, Fu W
The American journal of sports medicine 2024 Jan;52(1):140-154
The American journal of sports medicine 2024 Jan;52(1):140-154
Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway.
Liu Y, Zhou C, Tan J, Wu T, Pan C, Liu J, Cheng X
Chemical biology & drug design 2024 Jan;103(1):e14382
Chemical biology & drug design 2024 Jan;103(1):e14382
Exercise-induced modulation of myokine irisin on muscle-bone unit in the rat model of post-traumatic osteoarthritis.
Shang X, Hao X, Hou W, Liu J, Chi R, Deng X, Pan C, Xu T
Journal of orthopaedic surgery and research 2024 Jan 9;19(1):49
Journal of orthopaedic surgery and research 2024 Jan 9;19(1):49
Carveol alleviates osteoarthritis progression by acting on synovial macrophage polarization transformation: An in vitro and in vivo study.
Chen S, Xu H, He Y, Meng C, Fan Y, Qu Y, Wang Y, Zhou W, Huang X, You H
Chemico-biological interactions 2024 Jan 5;387:110781
Chemico-biological interactions 2024 Jan 5;387:110781
COL3A1 is a potential diagnostic biomarker for synovial chondromatosis and affects the cell cycle and migration of chondrocytes.
Chen WK, Zhang HJ, Liu J, Dai Z, Zhan XL
International immunopharmacology 2024 Jan 25;127:111416
International immunopharmacology 2024 Jan 25;127:111416
Calycosin ameliorates osteoarthritis by regulating the imbalance between chondrocyte synthesis and catabolism.
Su H, Yan Q, Du W, Hu E, Yang Z, Zhang W, Li Y, Tang T, Zhao S, Wang Y
BMC complementary medicine and therapies 2024 Jan 22;24(1):48
BMC complementary medicine and therapies 2024 Jan 22;24(1):48
The CREB1 inhibitor 666-15 maintains cartilage homeostasis and mitigates osteoarthritis progression.
Wang Y, Wu Z, Yan G, Li S, Zhang Y, Li G, Wu C
Bone & joint research 2024 Jan 2;13(1):4-18
Bone & joint research 2024 Jan 2;13(1):4-18
Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
Ma Z, Lu H, Feng X, Du T, Li J, Zhang Q, Gu X, Shao Y, Jing X, Su C
International journal of molecular medicine 2024 Feb;53(2)
International journal of molecular medicine 2024 Feb;53(2)
FOXO3-Activated HOTTIP Sequesters miR-615-3p away from COL2A1 to Mitigate Intervertebral Disc Degeneration.
Hao Y, Zhu G, Yu L, Ren Z, Zhou W, Zhang P, Lian X
The American journal of pathology 2024 Feb;194(2):280-295
The American journal of pathology 2024 Feb;194(2):280-295
Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6.
Wang X, Li X, Zhou J, Lei Z, Yang X
Chemico-biological interactions 2024 Feb 25;390:110890
Chemico-biological interactions 2024 Feb 25;390:110890
P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability.
Zheng Z, Shang X, Sun K, Hou Y, Zhang X, Xu J, Liu H, Ruan Z, Hou L, Guo Z, Wang G, Xu F, Guo F
Free radical biology & medicine 2024 Feb 20;212:336-348
Free radical biology & medicine 2024 Feb 20;212:336-348
SYNJ2BP ameliorates intervertebral disc degeneration by facilitating mitochondria-associated endoplasmic reticulum membrane formation and mitochondrial Zn(2+) homeostasis.
Song Y, Geng W, Zhu D, Liang H, Du Z, Tong B, Wang K, Li S, Gao Y, Feng X, Liao Z, Mei R, Yang C
Free radical biology & medicine 2024 Feb 20;212:220-233
Free radical biology & medicine 2024 Feb 20;212:220-233
PUD@HA/PEEK Scaffold Induces Subchondral Bone Regeneration to Repair Osteochondral Defect in Rabbits.
Li M, Teng M, Mao G, Sun Y, Liu S, Li R, Wang X, Qiu Y
ACS biomaterials science & engineering 2024 Feb 12;10(2):1006-1017
ACS biomaterials science & engineering 2024 Feb 12;10(2):1006-1017
CARMA3 Drives NF-κB Activation and Promotes Intervertebral Disc Degeneration: Involvement of CARMA3-BCL10-MALT1 Signalosome.
Liu Y, Zhang G, Wu J, Meng Y, Hu J, Fu H, Yang D
Inflammation 2024 Dec;47(6):1936-1951
Inflammation 2024 Dec;47(6):1936-1951
Macrophage polarization and macrophage-related factor expression in hypertrophy of the ligamentum flavum.
Jiang C, Wang W, Chen YL, Chen JH, Zhang ZW, Li J, Yang ZC, Li XC
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2024 Dec;33(12):4476-4487
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2024 Dec;33(12):4476-4487
Enhanced therapeutic potential of a self-healing hyaluronic acid hydrogel for early intervention in osteoarthritis.
Wu D, Yang S, Gong Z, Zhu X, Hong J, Wang H, Xu W, Lai J, Wang X, Lu J, Fang X, Jiang G, Zhu J
Materials today. Bio 2024 Dec;29:101353
Materials today. Bio 2024 Dec;29:101353
Injectable decellularized Wharton's jelly hydrogel containing CD56(+) umbilical cord mesenchymal stem cell-derived exosomes for meniscus tear healing and cartilage protection.
Kang S, Shi X, Chen Y, Zhang L, Liu Q, Lin Z, Lu H, Pan H
Materials today. Bio 2024 Dec;29:101258
Materials today. Bio 2024 Dec;29:101258
The active ingredient of Evodia rutaecarpa reduces inflammation in knee osteoarthritis rats through blocking calcium influx and NF-κB pathway.
Gao Y, Wang S, Gao Y, Yang L
Basic & clinical pharmacology & toxicology 2024 Dec;135(6):705-719
Basic & clinical pharmacology & toxicology 2024 Dec;135(6):705-719
Controlled Release of Ceria and Ferric Oxide Nanoparticles via Collagen Hydrogel for Enhanced Osteoarthritis Therapy.
Chen X, Wang L, Zhang J, Yan H, Wang S, Xiao J
Advanced healthcare materials 2024 Dec;13(32):e2401507
Advanced healthcare materials 2024 Dec;13(32):e2401507
Ultra-Long-Term Anti-Inflammatory Polyphenol Capsule to Remodel the Microenvironment for Accelerating Osteoarthritis Healing by Single Dosage.
Wei S, Shou Z, Yang D, Sun L, Guo Y, Wang Y, Zan X, Li L, Zhang C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(48):e2407425
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(48):e2407425
Ginkgolide A enhances FoxO1 expression and reduces endoplasmic reticulum stress to mitigate osteoarthritis in mice.
Yu H, Liang J, Bao Y, Chen K, Jin Y, Li X, Chen H, Gou Y, Lu K, Lin Z
International immunopharmacology 2024 Dec 5;142(Pt B):113116
International immunopharmacology 2024 Dec 5;142(Pt B):113116
Nuciferine ameliorates osteoarthritis: An in vitro and in vivo study.
Peng M, Shen G, Tu Q, Zhang W, Wang J
International immunopharmacology 2024 Dec 5;142(Pt B):113098
International immunopharmacology 2024 Dec 5;142(Pt B):113098
Kongensin A targeting PI3K attenuates inflammation-induced osteoarthritis by modulating macrophage polarization and alleviating inflammatory signaling.
Guo Y, Wang P, Hu B, Wang L, Zhang Y, Wang J
International immunopharmacology 2024 Dec 5;142(Pt A):112948
International immunopharmacology 2024 Dec 5;142(Pt A):112948
True-bone-ceramics / type I collagen scaffolds for repairing osteochondral defect.
Jiang Y, Li T, Lou Y, Liu B, Liu Y, Li T, Zhang D
Journal of materials science. Materials in medicine 2024 Dec 30;36(1):1
Journal of materials science. Materials in medicine 2024 Dec 30;36(1):1
Guilu Erxian glue reduces endoplasmic reticulum stress-mediated apoptosis and restores the balance of extracellular matrix synthesis and degradation in chondrocytes by inhibiting the ATF6/GRP78/CHOP signaling pathway.
Geng Q, Wu W, Yang M, Gu F, Cai W, Qin Y, Wei L, Wang H, Li N
Heliyon 2024 Dec 30;10(24):e39987
Heliyon 2024 Dec 30;10(24):e39987
LCCP exposure leads to skin cell senescence damage by triggering oxidative stress mediated by mitochondrial Ca(2+) overload.
Zhang M, Zhang R, Kong Y, Li J, Wang G, Wu D, Wu M, Lan H
International immunopharmacology 2024 Dec 25;143(Pt 2):113471
International immunopharmacology 2024 Dec 25;143(Pt 2):113471
Enhancing GFPT1 expression with glutamine protects chondrocytes in osteoarthritis.
Zhang Z, Li X, Guo W, Huang Z
International immunopharmacology 2024 Dec 25;143(Pt 2):113427
International immunopharmacology 2024 Dec 25;143(Pt 2):113427
Taurine rescues intervertebral disc degeneration by activating mitophagy through the PINK1/Parkin pathway.
Lin S, Li T, Zhang B, Wang P
Biochemical and biophysical research communications 2024 Dec 20;739:150587
Biochemical and biophysical research communications 2024 Dec 20;739:150587
Targeted lipid nanoparticles distributed in hydrogel treat osteoarthritis by modulating cholesterol metabolism and promoting endogenous cartilage regeneration.
Zhao Z, Wang P, Li Z, Wei X, Li S, Lu X, Dai S, Huang B, Man Z, Li W
Journal of nanobiotechnology 2024 Dec 20;22(1):786
Journal of nanobiotechnology 2024 Dec 20;22(1):786
Potential Effects of Indomethacin on Alleviating Osteoarthritis Progression in Vitro.
Zhao X, Wang T, Li N, Meng Z, Wang W, Wang B, Song D
Journal of musculoskeletal & neuronal interactions 2024 Dec 1;24(4):409-419
Journal of musculoskeletal & neuronal interactions 2024 Dec 1;24(4):409-419
Supraspinatus Tendon Reconstruction Versus the Bridging Technique in a Rat Model: Histological, Biomechanical, and Functional Outcomes.
Liao Y, Wang J, Zhou Z, Tang B, Li H, Mu Y, Nie M, Yu S, Zhou B
The American journal of sports medicine 2024 Aug;52(10):2628-2638
The American journal of sports medicine 2024 Aug;52(10):2628-2638
Diatomite-incorporated hierarchical scaffolds for osteochondral regeneration.
Deng C, Qin C, Li Z, Lu L, Tong Y, Yuan J, Yin F, Cheng Y, Wu C
Bioactive materials 2024 Aug;38:305-320
Bioactive materials 2024 Aug;38:305-320
Excessive mechanical loading promotes osteoarthritis development by upregulating Rcn2.
Liu Y, Chen P, Hu B, Xiao Y, Su T, Luo X, Tu M, Cai G
Biochimica et biophysica acta. Molecular basis of disease 2024 Aug;1870(6):167251
Biochimica et biophysica acta. Molecular basis of disease 2024 Aug;1870(6):167251
Degrasyn alleviates osteoarthritis by blocking macrophagic pyroptosis via suppressing NLRP3/GSDMD signaling pathway and protecting chondrocytes.
Xie S, Wang L, Lu C, Chen H, Ding Y, Jian X, Zhang Z, Zhu L
Cellular signalling 2024 Aug;120:111220
Cellular signalling 2024 Aug;120:111220
Zwitterion-Lubricated Hydrogel Microspheres Encapsulated with Metformin Ameliorate Age-Associated Osteoarthritis.
Hou J, Lin Y, Zhu C, Chen Y, Lin R, Lin H, Liu D, Guan D, Yu B, Wang J, Wu H, Cui Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2402477
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2402477
Pulsed electromagnetic fields potentiate bone marrow mesenchymal stem cell chondrogenesis by regulating the Wnt/β-catenin signaling pathway.
Song K, Hu J, Yang M, Xia Y, He C, Yang Y, Zhu S
Journal of translational medicine 2024 Aug 6;22(1):741
Journal of translational medicine 2024 Aug 6;22(1):741
Mulberroside A mitigates intervertebral disc degeneration by inhibiting MAPK and modulating Ppar-γ/NF-κB pathways.
Xu T, Zhao H, Fang X, Wang S, Li J, Wu H, Hu W, Lu R
Journal of inflammation (London, England) 2024 Aug 28;21(1):32
Journal of inflammation (London, England) 2024 Aug 28;21(1):32
A(2A)R regulate inflammation through PKA/NF-κB signaling pathways in intervertebral disc degeneration.
Liu W, Li Q, Fang W, Cai L, Wang Z, Kou B, Zhou C, Zhou Y, Yao Z, Wei M, Zhang S
European journal of medical research 2024 Aug 27;29(1):433
European journal of medical research 2024 Aug 27;29(1):433
Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage.
Kan T, Li H, Hou L, Cui J, Wang Y, Sun L, Wang L, Yan M, Yu Z
iScience 2024 Aug 16;27(8):110507
iScience 2024 Aug 16;27(8):110507
Zhiqiao Gancao decoction regulated JAK2/STAT3/ macrophage M1 polarization to ameliorate intervertebral disc degeneration.
Huang Z, Shen X, Chen H, Zhu Z, Lu B, Zhang L, Liu Y, Li Y, Xu B
Heliyon 2024 Aug 15;10(15):e34715
Heliyon 2024 Aug 15;10(15):e34715
Inhibiting DNA methyltransferase DNMT3B confers protection against ferroptosis in nucleus pulposus and ameliorates intervertebral disc degeneration via upregulating SLC40A1.
Chen J, Yang X, Li Q, Ma J, Li H, Wang L, Chen Z, Quan Z
Free radical biology & medicine 2024 Aug 1;220:139-153
Free radical biology & medicine 2024 Aug 1;220:139-153
Injectable Microgels with Hybrid Exosomes of Chondrocyte-Targeted FGF18 Gene-Editing and Self-Renewable Lubrication for Osteoarthritis Therapy.
Chen M, Lu Y, Liu Y, Liu Q, Deng S, Liu Y, Cui X, Liang J, Zhang X, Fan Y, Wang Q
Advanced materials (Deerfield Beach, Fla.) 2024 Apr;36(16):e2312559
Advanced materials (Deerfield Beach, Fla.) 2024 Apr;36(16):e2312559
Injectable pathological microenvironment-responsive anti-inflammatory hydrogels for ameliorating intervertebral disc degeneration.
Liu L, Wang W, Huang L, Xian Y, Ma W, Fan J, Li Y, Liu H, Zheng Z, Wu D
Biomaterials 2024 Apr;306:122509
Biomaterials 2024 Apr;306:122509
Baicalin Maintains Articular Cartilage Homeostasis and Alleviates Osteoarthritis by Activating FOXO1.
Wei Q, Yu Z, Yang P, Chen X
Journal of medicinal food 2024 Apr;27(4):301-311
Journal of medicinal food 2024 Apr;27(4):301-311
Injectable silk fibroin peptide nanofiber hydrogel composite scaffolds for cartilage regeneration.
Wu D, Li J, Wang C, Su Z, Su H, Chen Y, Yu B
Materials today. Bio 2024 Apr;25:100962
Materials today. Bio 2024 Apr;25:100962
The NLRX1-SLC39A7 complex orchestrates mitochondrial dynamics and mitophagy to rejuvenate intervertebral disc by modulating mitochondrial Zn(2+) trafficking.
Song Y, Liang H, Li G, Ma L, Zhu D, Zhang W, Tong B, Li S, Gao Y, Wu X, Zhang Y, Feng X, Wang K, Yang C
Autophagy 2024 Apr;20(4):809-829
Autophagy 2024 Apr;20(4):809-829
Spermidine ameliorates osteoarthritis via altering macrophage polarization.
Ou Q, Tang S, Zhu J, Xue S, Huang H, Zhao Y, Cai Y, Wu C, Chen J, Ruan G, Ding C
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167083
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167083
Tenascin-C promotes endochondral ossification and fracture healing through Hedgehog and Hippo signaling.
Zhong F, Hao W, Chao H, Li Z, Chen S, Li S, Zhang S, Zhang K, Li Z, Liu H
Biochemical and biophysical research communications 2024 Apr 9;703:149634
Biochemical and biophysical research communications 2024 Apr 9;703:149634
Urolithin B reduces cartilage degeneration and alleviates osteoarthritis by inhibiting inflammation.
Xue H, Zhou H, Lou Q, Yuan P, Feng Z, Qiao L, Zhang J, Xie H, Shen Y, Ma Q, Wang S, Zhang B, Ye H, Cheng J, Sun X, Shi P
Food & function 2024 Apr 2;15(7):3552-3565
Food & function 2024 Apr 2;15(7):3552-3565
miR-1 Inhibits the Ferroptosis of Chondrocyte by Targeting CX43 and Alleviates Osteoarthritis Progression.
Zhou M, Zhai C, Shen K, Liu G, Liu L, He J, Chen J, Xu Y
Journal of immunology research 2023;2023:2061071
Journal of immunology research 2023;2023:2061071
Pioglitazone-Loaded Cartilage-Targeted Nanomicelles (Pio@C-HA-DOs) for Osteoarthritis Treatment.
Chen J, Xu W, Dai T, Jiao S, Xue X, Jiang J, Li S, Meng Q
International journal of nanomedicine 2023;18:5871-5890
International journal of nanomedicine 2023;18:5871-5890
The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies.
Li Y, Zhu S, Luo J, Tong Y, Zheng Y, Ji L, He Z, Jing Q, Huang J, Zhang Y, Bi Q
Drug design, development and therapy 2023;17:1515-1529
Drug design, development and therapy 2023;17:1515-1529
Therapeutic Effect of Acupotomy at Sanheyang for Cartilage Collagen Damage in Moderate Knee Osteoarthritis: A Rabbit Model.
Li Y, Hou Y, Sun J, Wei J, Chai Y, Guo M, Wang R
Journal of inflammation research 2023;16:2241-2254
Journal of inflammation research 2023;16:2241-2254
Digoxin protects against intervertebral disc degeneration via TNF/NF-κB and LRP4 signaling.
Meng Q, Liu K, Liu Z, Liu J, Tian Z, Qin S, Wei J, Cheng L
Frontiers in immunology 2023;14:1251517
Frontiers in immunology 2023;14:1251517
Microtubule stabilization promotes the synthesis of type 2 collagen in nucleus pulposus cell by activating hippo-yap pathway.
Zhang X, Shu S, Feng Z, Qiu Y, Bao H, Zhu Z
Frontiers in pharmacology 2023;14:1102318
Frontiers in pharmacology 2023;14:1102318
Overexpression of fibroblast growth factor receptor 2 in bone marrow mesenchymal stem cells enhances osteogenesis and promotes critical cranial bone defect regeneration.
Zhou Y, Zhu P, Shen S, Wang Y, Li B, Guo B, Li H
Frontiers in cell and developmental biology 2023;11:1208239
Frontiers in cell and developmental biology 2023;11:1208239
Quiescence preconditioned nucleus pulposus stem cells alleviate intervertebral disc degeneration by enhancing cell survival via adaptive metabolism pattern in rats.
Chen Q, Yang Q, Pan C, Ding R, Wu T, Cao J, Wu H, Zhao X, Li B, Cheng X
Frontiers in bioengineering and biotechnology 2023;11:1073238
Frontiers in bioengineering and biotechnology 2023;11:1073238
Identification of EGFR as an essential regulator in chondrocytes ferroptosis of osteoarthritis using bioinformatics, in vivo, and in vitro study.
Sun H, Peng G, Chen K, Xiong Z, Zhuang Y, Liu M, Ning X, Yang H, Deng J
Heliyon 2023 Sep;9(9):e19975
Heliyon 2023 Sep;9(9):e19975
Donor-Matched Peripheral Blood-Derived Mesenchymal Stem Cells Combined With Platelet-Rich Plasma Synergistically Ameliorate Surgery-Induced Osteoarthritis in Rabbits: An In Vitro and In Vivo Study.
Zhang K, Xu T, Xie H, Li J, Fu W
The American journal of sports medicine 2023 Sep;51(11):3008-3024
The American journal of sports medicine 2023 Sep;51(11):3008-3024
Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages.
Zhao X, Sun Z, Xu B, Duan W, Chang L, Lai K, Ye Z
Journal of nanobiotechnology 2023 Sep 4;21(1):317
Journal of nanobiotechnology 2023 Sep 4;21(1):317
Function and regulation of nuclear factor 1 X-type on chondrocyte proliferation and differentiation.
Pan D, Zhong J, Zhang J, Dong H, Zhao D, Zhang H, Yao B
Gene 2023 Sep 25;881:147620
Gene 2023 Sep 25;881:147620
Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis.
Zhao S, Xiu G, Wang J, Wen Y, Lu J, Wu B, Wang G, Yang D, Ling B, Du D, Xu J
Journal of nanobiotechnology 2023 Sep 22;21(1):341
Journal of nanobiotechnology 2023 Sep 22;21(1):341
TGF-β1 Triggers Salivary Hypofunction via Attenuating Protein Secretion and AQP5 Expression in Human Submandibular Gland Cells.
Chen Z, Chen X, Zhu B, Yu H, Bao X, Hou Y, Song W, Sun S, Li Z
Journal of proteome research 2023 Sep 1;22(9):2803-2813
Journal of proteome research 2023 Sep 1;22(9):2803-2813
Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF‑κB and MAPK signalling transduction through integrin αVβ3.
Wan J, Li M, Yuan X, Yu X, Chen A, Shao M, Kang H, Cheng P
International journal of molecular medicine 2023 Oct;52(4)
International journal of molecular medicine 2023 Oct;52(4)
An in vitro and in vivo study: Valencene protects cartilage and alleviates the progression of osteoarthritis by anti-oxidative stress and anti-inflammatory effects.
Chen S, Meng C, He Y, Xu H, Qu Y, Wang Y, Fan Y, Huang X, You H
International immunopharmacology 2023 Oct;123:110726
International immunopharmacology 2023 Oct;123:110726
Exploring the chondroprotective effect of Chaenomeles speciosa on Glucose-6-Phosphate Isomerase model mice using an integrated approach of network pharmacology and experimental validation.
Duan Z, Jin C, Deng Y, Liu J, Gu C, Wang J, Cai X, Li S, Zhou Y
Journal of ethnopharmacology 2023 Oct 5;314:116553
Journal of ethnopharmacology 2023 Oct 5;314:116553
Focused low-intensity pulsed ultrasound alleviates osteoarthritis via restoring impaired FUNDC1-mediated mitophagy.
Ye H, Li D, Wei X, Yu L, Jia L
iScience 2023 Oct 20;26(10):107772
iScience 2023 Oct 20;26(10):107772
Pentraxin 3 deficiency ameliorates the severity of osteoarthritis and alleviates inflammation.
Qiu C, Liu J, Li J, Di D, Li M, Liu T, Wang X, Zhao Y, Wang L, Liu X
Biochemical and biophysical research communications 2023 Oct 15;677:20-25
Biochemical and biophysical research communications 2023 Oct 15;677:20-25
Dapagliflozin suppress endoplasmic reticulum stress mediated apoptosis of chondrocytes by activating Sirt1.
Liu Z, Huang J, Wang X, Deng S, Zhou J, Gong Z, Li X, Wang Y, Yang J, Hu Y
Chemico-biological interactions 2023 Oct 1;384:110724
Chemico-biological interactions 2023 Oct 1;384:110724
α-Ketoglutaric acid ameliorates intervertebral disk degeneration by blocking the IL-6/JAK2/STAT3 pathway.
Xu HW, Fang XY, Liu XW, Zhang SB, Yi YY, Chang SJ, Chen H, Wang SJ
American journal of physiology. Cell physiology 2023 Oct 1;325(4):C1119-C1130
American journal of physiology. Cell physiology 2023 Oct 1;325(4):C1119-C1130
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death.
Chen X, Chen J, Miao C, Yin G, Zhang Z, Sun R, Ni S
Molecular medicine reports 2023 Nov;28(5)
Molecular medicine reports 2023 Nov;28(5)
Activation of the Nrf-2 pathway by pinocembrin safeguards vertebral endplate chondrocytes against apoptosis and degeneration caused by oxidative stress.
Wang H, Liu X, Yang H, Jing X, Wang W, Liu X, Zhang B, Liu X, Shao Y, Cui X
Life sciences 2023 Nov 15;333:122162
Life sciences 2023 Nov 15;333:122162
BSHXF-medicated serum combined with ADSCs regulates the TGF-β1/Smad pathway to repair oxidatively damaged NPCs and its component analysis.
Duan J, Li Z, Liu E, Long H, Chen L, Yang S
Journal of ethnopharmacology 2023 Nov 15;316:116692
Journal of ethnopharmacology 2023 Nov 15;316:116692
Sophisticated Magneto-Mechanical Actuation Promotes In Situ Stem Cell Assembly and Chondrogenesis for Treating Osteoarthritis.
Deng C, Li Z, Lu L, Zhang H, Chen R, Liu Y, Tong Y, Fan OR, Huang W, Sun YE, Yin F, Cheng Y
ACS nano 2023 Nov 14;17(21):21690-21707
ACS nano 2023 Nov 14;17(21):21690-21707
A20 ameliorates disc degeneration by suppressing mTOR/BNIP3 axis-mediated mitophagy.
Peng X, Zhang C, Gao JW, Wang F, Bao JP, Zhou ZM, Sun R, Ji HY, Vlf C, Wu XT
Genes & genomics 2023 May;45(5):657-671
Genes & genomics 2023 May;45(5):657-671
Integrin expression and extracellular matrix adhesion of septoclasts, pericytes, and endothelial cells at the chondro-osseous junction and the metaphysis of the proximal tibia in young mice.
Bando Y, Nagasaka A, Onozawa G, Sakiyama K, Owada Y, Amano O
Journal of anatomy 2023 May;242(5):831-845
Journal of anatomy 2023 May;242(5):831-845
The Bcr-Abl inhibitor DCC-2036 inhibits necroptosis and ameliorates osteoarthritis by targeting RIPK1 and RIPK3 kinases.
Piao L, Wu D, Rui C, Yang Y, Liu S, Liu J, Jin Z, Zhang H, Feng X, Bai L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114528
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114528
BuShen JianGu Fang alleviates cartilage degeneration via regulating multiple genes and signaling pathways to activate NF-κB/Sox9 axis.
Zhou Z, Lv C, Wang Y, Zhang B, Liu L, Yang J, Leng X, Zhao D, Yao B, Wang J, Dong H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154742
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154742
An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment.
Li G, Liu S, Chen Y, Zhao J, Xu H, Weng J, Yu F, Xiong A, Udduttula A, Wang D, Liu P, Chen Y, Zeng H
Nature communications 2023 May 31;14(1):3159
Nature communications 2023 May 31;14(1):3159
Polydopamine-Pd nanozymes as potent ROS scavengers in combination with near-infrared irradiation for osteoarthritis treatment.
Hu H, Yang J, Zhong Y, Wang J, Cai J, Luo C, Jin Z, Gao M, He M, Zheng L
iScience 2023 May 19;26(5):106605
iScience 2023 May 19;26(5):106605
Preparation of Melatonin-Loaded Nanoparticles with Targeting and Sustained Release Function and Their Application in Osteoarthritis.
Liang H, Yan Y, Sun W, Ma X, Su Z, Liu Z, Chen Y, Yu B
International journal of molecular sciences 2023 May 14;24(10)
International journal of molecular sciences 2023 May 14;24(10)
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
Lu R, Xu H, Deng X, Wang Y, He Z, Xu S, Liang S, Huang X, You H, Guo F, Cheng P, Chen AM
Journal of orthopaedic translation 2023 Mar;39:74-87
Journal of orthopaedic translation 2023 Mar;39:74-87
METTL3 promotes SMSCs chondrogenic differentiation by targeting the MMP3, MMP13, and GATA3.
Hu B, Zou X, Yu Y, Jiang Y, Xu H
Regenerative therapy 2023 Mar;22:148-159
Regenerative therapy 2023 Mar;22:148-159
An esterase-responsive ibuprofen nano-micelle pre-modified embryo derived nucleus pulposus progenitor cells promote the regeneration of intervertebral disc degeneration.
Xia KS, Li DD, Wang CG, Ying LW, Wang JK, Yang B, Shu JW, Huang XP, Zhang YA, Yu C, Zhou XP, Li FC, Slater NKH, Tang JB, Chen QX, Liang CZ
Bioactive materials 2023 Mar;21:69-85
Bioactive materials 2023 Mar;21:69-85
PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway.
Cui X, Liu X, Kong P, Du T, Li T, Yang G, Zhang W, Jing X, Wang W
Aging 2023 Mar 24;15(6):2275-2292
Aging 2023 Mar 24;15(6):2275-2292
Thermosensitive hydrogel for cartilage regeneration via synergistic delivery of SDF-1α like polypeptides and kartogenin.
Yuan X, Wan J, Yang Y, Huang L, Zhou C, Su J, Hua S, Pu H, Zou Y, Zhu H, Jiang X, Xiao J
Carbohydrate polymers 2023 Mar 15;304:120492
Carbohydrate polymers 2023 Mar 15;304:120492
Experimental study of miR-503 regulating the activity as well as the function of degenerated human nucleus pulposus cells of the intervertebral disc through inhibiting Wnt pathway.
Shi X, Tian S, Tian Y
Journal of musculoskeletal & neuronal interactions 2023 Mar 1;23(1):131-144
Journal of musculoskeletal & neuronal interactions 2023 Mar 1;23(1):131-144
A comprehensive analysis of single-cell RNA transcriptome reveals unique SPP1+ chondrocytes in human osteoarthritis.
Qu Y, Wang Y, Wang S, Yu X, He Y, Lu R, Chen S, Meng C, Xu H, Pei W, Ni B, Zhang R, Huang X, You H
Computers in biology and medicine 2023 Jun;160:106926
Computers in biology and medicine 2023 Jun;160:106926
Stevioside protects primary articular chondrocytes against IL-1β-induced inflammation and catabolism by targeting integrin.
Wan J, Zhu Z, He Z, Wu H, Chen A, Zhu W, Cheng P
International immunopharmacology 2023 Jun;119:110261
International immunopharmacology 2023 Jun;119:110261
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway.
Yang G, Liu X, Jing X, Wang J, Wang H, Chen F, Wang W, Shao Y, Cui X
International immunopharmacology 2023 Jun;119:110159
International immunopharmacology 2023 Jun;119:110159
Silencing of NOTCH3 Signaling in Meniscus Smooth Muscle Cells Inhibits Fibrosis and Exacerbates Degeneration in a HEYL-Dependent Manner.
Sun H, Liu F, Lin Z, Jiang Z, Wen X, Xu J, Zhang Z, Ma R
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jun;10(16):e2207020
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jun;10(16):e2207020
tsRNA-04002 alleviates intervertebral disk degeneration by targeting PRKCA to inhibit apoptosis of nucleus pulposus cells.
Pan J, Liu Z, Shen B, Xu J, Dai G, Xu W, Wang J, Li L, Cheng L
Journal of orthopaedic surgery and research 2023 Jun 7;18(1):413
Journal of orthopaedic surgery and research 2023 Jun 7;18(1):413
Du Huo Ji Sheng Tang inhibits Notch1 signaling and subsequent NLRP3 activation to alleviate cartilage degradation in KOA mice.
Chen WJ, Zhuang Y, Peng W, Cui W, Zhang SJ, Wang JW
Chinese medicine 2023 Jun 29;18(1):80
Chinese medicine 2023 Jun 29;18(1):80
Wound Gel with Antimicrobial Effects Based on Polyvinyl Alcohol and Functional Aryloxycyclotriphosphazene.
Yudaev P, Butorova I, Chuev V, Posokhova V, Klyukin B, Chistyakov E
Polymers 2023 Jun 27;15(13)
Polymers 2023 Jun 27;15(13)
TNF-α activates RELA expression via TNFRSF1B to upregulate OPA1 expression and inhibit chondrogenic differentiation of human adipose stem cells.
Guo J, Ye W, Wu X, Huang H, Li B, Sun Z, Ren Z, Yang Z
Journal of orthopaedic surgery and research 2023 Jun 13;18(1):430
Journal of orthopaedic surgery and research 2023 Jun 13;18(1):430
EIF4A3-Induced Upregulation of hsa_circ_0040039 is a Biomarker and Aggravates IL-1β-Stimulated Intervertebral Disc Degeneration.
Li L, Cao Y, Deng H, Jia J, Fan X
Applied biochemistry and biotechnology 2023 Jul;195(7):4292-4307
Applied biochemistry and biotechnology 2023 Jul;195(7):4292-4307
Activating Mitochondrial Sirtuin 3 in Chondrocytes Alleviates Aging-Induced Fibrocartilage Layer Degeneration and Promotes Healing of Degenerative Rotator Cuff Injury.
Xie S, Guan C, Huang T, Yang G, Hu J, Sun D, Lu H
The American journal of pathology 2023 Jul;193(7):939-949
The American journal of pathology 2023 Jul;193(7):939-949
Exosomal miR-429 derived from adipose-derived stem cells ameliorated chondral injury in osteoarthritis via autophagy by targeting FEZ2.
Meng C, Na Y, Han C, Ren Y, Liu M, Ma P, Bai R
International immunopharmacology 2023 Jul;120:110315
International immunopharmacology 2023 Jul;120:110315
Targeting macrophagic PIM-1 alleviates osteoarthritis by inhibiting NLRP3 inflammasome activation via suppressing mitochondrial ROS/Cl(-) efflux signaling pathway.
Zhang Z, Xie S, Qian J, Gao F, Jin W, Wang L, Yan L, Chen H, Yao W, Li M, Wang X, Zhu L
Journal of translational medicine 2023 Jul 8;21(1):452
Journal of translational medicine 2023 Jul 8;21(1):452
Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy.
Bao J, Gao W, Zhang W, Wang D, Pan H
Journal of orthopaedic surgery and research 2023 Jul 6;18(1):485
Journal of orthopaedic surgery and research 2023 Jul 6;18(1):485
Pelargonidin ameliorates inflammatory response and cartilage degeneration in osteoarthritis via suppressing the NF-κB pathway.
Zeng Z, Li H, Luo C, Hu W, Weng TJ, Shuang F
Archives of biochemistry and biophysics 2023 Jul 15;743:109668
Archives of biochemistry and biophysics 2023 Jul 15;743:109668
Novel insights into the effect of deer IGF-1 on chondrocyte viability and IL-1β-induced inflammation response.
Zhong J, Zhang J, Zhou Z, Pan D, Zhao D, Dong H, Yao B
Journal of biochemical and molecular toxicology 2023 Jan;37(1):e23227
Journal of biochemical and molecular toxicology 2023 Jan;37(1):e23227
Activation of the kynurenine-aryl hydrocarbon receptor axis impairs the chondrogenic and chondroprotective effects of human umbilical cord-derived mesenchymal stromal cells in osteoarthritis rats.
Wang X, Zhao Y, Li S, Wang Y, Jia C, Yang X, Li S, Zhang B, Wei W, Chang Y
Human cell 2023 Jan;36(1):163-177
Human cell 2023 Jan;36(1):163-177
Increased FGFR3 is involved in T-2 toxin-induced lesions of hypertrophic cartilage associated with endemic osteoarthritis.
Zhang Y, Fang Q, Liu Y, Zhang D, He Y, Liu F, Sun K, Chen J
Human & experimental toxicology 2023 Jan-Dec;42:9603271231219480
Human & experimental toxicology 2023 Jan-Dec;42:9603271231219480
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.
Tian Y, Feng X, Zhou Z, Qin S, Chen S, Zhao J, Hou J, Liu D
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1499-1509
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1499-1509
Hypoxia-Inducible Factor-1α Protects Against Intervertebral Disc Degeneration Through Antagonizing Mitochondrial Oxidative Stress.
Yang W, Jia C, Liu L, Fu Y, Wu Y, Liu Z, Yu R, Ma X, Gong A, Liu F, Xia Y, Hou Y, Li Y, Zhang L
Inflammation 2023 Feb;46(1):270-284
Inflammation 2023 Feb;46(1):270-284
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Dai Z, Xia C, Zhao T, Wang H, Tian H, Xu O, Zhu X, Zhang J, Chen P
Materials today. Bio 2023 Feb;18:100512
Materials today. Bio 2023 Feb;18:100512
Indirubin protects chondrocytes and alleviates OA by inhibiting the MAPK and NF-κB pathways.
Wang X, Guo Z, Lin J, Sun K, Wang G, Hou L, Xu J, Guo J, Zhang X, Guo F, Wei Y
International immunopharmacology 2023 Feb;115:109624
International immunopharmacology 2023 Feb;115:109624
Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways.
Lu R, Wei Z, Wang Z, Xu S, Sun K, Cheng P, Huang X, You H, Guo F, Liang S, Chen AM
iScience 2023 Feb 17;26(2):105936
iScience 2023 Feb 17;26(2):105936
Astaxanthin Promotes the Survival of Adipose-Derived Stem Cells by Alleviating Oxidative Stress via Activating the Nrf2 Signaling Pathway.
Yang CS, Guo XS, Yue YY, Wang Y, Jin XL
International journal of molecular sciences 2023 Feb 14;24(4)
International journal of molecular sciences 2023 Feb 14;24(4)
Matrix Stiffness Activating YAP/TEAD1-Cyclin B1 in Nucleus Pulposus Cells Promotes Intervertebral Disc Degeneration.
Zhou Z, Suo Y, Bai J, Lin F, Gao X, Shan H, Ni Y, Zhou X, Sheng L, Dai J
Aging and disease 2023 Feb 11;
Aging and disease 2023 Feb 11;
Hypoxia dissociates HDAC6/FOXO1 complex and aggregates them into nucleus to regulate autophagy and osteogenic differentiation.
Xu Y, Wang Y, Xiao H, Li Y
Journal of periodontal research 2023 Dec;58(6):1248-1260
Journal of periodontal research 2023 Dec;58(6):1248-1260
Tranexamic Acid Causes Chondral Injury Through Chondrocytes Apoptosis Induced by Activating Endoplasmic Reticulum Stress.
Wang J, Liang S, Ma T, Chen S, Hu Y, Wang L
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 2023 Dec;39(12):2529-2546.e1
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 2023 Dec;39(12):2529-2546.e1
Enhancement and Repair of Degenerative Intervertebral Disc in Rats Using Platelet-Rich Plasma/Ferulic Acid Hydrogel.
Chai Q, Zhang B, Da Y, Wang W, Gao Y, Yao M, Zhu H, Yang X, Zhu Y
Cartilage 2023 Dec;14(4):506-515
Cartilage 2023 Dec;14(4):506-515
Cabozantinib prevents AGEs-induced degradation of type 2 collagen and aggrecan in human chondrocytes.
Dong Y, Lin L, Ji Y, Cheng X, Zhang Z
Aging 2023 Dec 6;15(23):13646-13654
Aging 2023 Dec 6;15(23):13646-13654
MiR-146b-5p enriched bioinspired exosomes derived from fucoidan-directed induction mesenchymal stem cells protect chondrocytes in osteoarthritis by targeting TRAF6.
Lou C, Jiang H, Lin Z, Xia T, Wang W, Lin C, Zhang Z, Fu H, Iqbal S, Liu H, Lin J, Wang J, Pan X, Xue X
Journal of nanobiotechnology 2023 Dec 18;21(1):486
Journal of nanobiotechnology 2023 Dec 18;21(1):486
Growth differentiation factor 5 inhibits lipopolysaccharide-mediated pyroptosis of nucleus pulposus mesenchymal stem cells via RhoA signaling pathway.
Zhu C, Zhou Q, Wang Z, Zhang J, Xu C, Ruan D
Molecular biology reports 2023 Aug;50(8):6337-6347
Molecular biology reports 2023 Aug;50(8):6337-6347
Ginsenoside compound K alleviates osteoarthritis by inhibiting NLRP3‑mediated pyroptosis.
Li Y, Wu J, Zhuo N
Experimental and therapeutic medicine 2023 Aug;26(2):406
Experimental and therapeutic medicine 2023 Aug;26(2):406
Exosomes derived from bone marrow mesenchymal stem cells pretreated with decellularized extracellular matrix enhance the alleviation of osteoarthritis through miR-3473b/phosphatase and tensin homolog axis.
Zhang Y, Qi G, Yan Y, Wang C, Wang Z, Jiang C, Jiang Z, Ma T, Zhang C, Yan Z
The journal of gene medicine 2023 Aug;25(8):e3510
The journal of gene medicine 2023 Aug;25(8):e3510
ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-κB signaling pathway.
Huang W, Tang H, Liu Y, Li W, Shimu AS, Li B, Zhu C
International immunopharmacology 2023 Aug;121:110433
International immunopharmacology 2023 Aug;121:110433
ADRM1/RPN13 attenuates cartilage extracellular matrix degradation via enhancing UCH37-mediated ALK5 deubiquitination.
Zhu M, Cao Z, Mo F, Shi S, Hu J, Xu Q, Quan K, Liang J, Li W, Hong X, Zhang B, Liu X, Dai M
International journal of biological macromolecules 2023 Aug 30;247:125670
International journal of biological macromolecules 2023 Aug 30;247:125670
Injectable photocrosslinking spherical hydrogel-encapsulated targeting peptide-modified engineered exosomes for osteoarthritis therapy.
Wan J, He Z, Peng R, Wu X, Zhu Z, Cui J, Hao X, Chen A, Zhang J, Cheng P
Journal of nanobiotechnology 2023 Aug 21;21(1):284
Journal of nanobiotechnology 2023 Aug 21;21(1):284
Kartogenin-loaded hydrogel promotes intervertebral disc repair via protecting MSCs against reactive oxygen species microenvironment by Nrf2/TXNIP/NLRP3 axis.
Wang F, Guo K, Nan L, Wang S, Lu J, Wang Q, Ba Z, Huang Y, Wu D
Free radical biology & medicine 2023 Aug 1;204:128-150
Free radical biology & medicine 2023 Aug 1;204:128-150
Piezo1-mediated mechanotransduction promotes entheseal pathological new bone formation in ankylosing spondylitis.
Chen S, Li Z, Chen D, Cui H, Wang J, Li Z, Li X, Zheng Z, Zhan Z, Liu H
Annals of the rheumatic diseases 2023 Apr;82(4):533-545
Annals of the rheumatic diseases 2023 Apr;82(4):533-545
Comparative transcriptome analysis provides insight into the molecular targets and signaling pathways of deer TGF-1 regulating chondrocytes proliferation and differentiation.
Zhou Z, Zhong J, Zhang J, Yang J, Leng X, Yao B, Wang X, Dong H
Molecular biology reports 2023 Apr;50(4):3155-3166
Molecular biology reports 2023 Apr;50(4):3155-3166
Withdrawn: X. Chen, Y. Li, M. Zhang, X. Wu, J. Zhu. Silencing LCK inactivates the NF-κB pathway to attenuate cartilage injury in osteoarthritis: An in vivo and in vitro study, published in The Journal of Gene Medicine.
The journal of gene medicine 2023 Apr;25(4):e3387
Lithium-Containing Biomaterials Stimulate Cartilage Repair through Bone Marrow Stromal Cells-Derived Exosomal miR-455-3p and Histone H3 Acetylation.
Liu L, Yu F, Chen L, Xia L, Wu C, Fang B
Advanced healthcare materials 2023 Apr;12(11):e2202390
Advanced healthcare materials 2023 Apr;12(11):e2202390
Integrated Cascade Nanozyme Remodels Chondrocyte Inflammatory Microenvironment in Temporomandibular Joint Osteoarthritis via Inhibiting ROS-NF-κB and MAPK Pathways.
Zhang Z, Yuan L, Liu Y, Wang R, Zhang Y, Yang Y, Wei H, Ma J
Advanced healthcare materials 2023 Apr;12(10):e2203195
Advanced healthcare materials 2023 Apr;12(10):e2203195
Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways.
Lu R, Wang YG, Qu Y, Wang SX, Peng C, You H, Zhu W, Chen A
Bone & joint research 2023 Apr 6;12(4):259-273
Bone & joint research 2023 Apr 6;12(4):259-273
Structural and biofunctional evaluation of decellularized jellyfish matrices.
Zhao J, Yu W, Zhang Q, Li X, Huang Y, Zhao S, Li T, Liu S, Li Y, Shan H
Journal of materials chemistry. B 2023 Apr 26;11(16):3740-3751
Journal of materials chemistry. B 2023 Apr 26;11(16):3740-3751
BRD4 Inhibition Suppresses Senescence and Apoptosis of Nucleus Pulposus Cells by Inducing Autophagy during Intervertebral Disc Degeneration: An In Vitro and In Vivo Study.
Zhang GZ, Chen HW, Deng YJ, Liu MQ, Wu ZL, Ma ZJ, He XG, Gao YC, Kang XW
Oxidative medicine and cellular longevity 2022;2022:9181412
Oxidative medicine and cellular longevity 2022;2022:9181412
Scrapie-Responsive Gene 1 Promotes Chondrogenic Differentiation of Umbilical Cord Mesenchymal Stem Cells via Wnt5a.
Zhou Y, Zheng T, Li L, Guo Y, Xiao J, Wang J, Du Z, Gao H, Tang W, Yang L, Hu H, Wang X, Meng M, Hou Z
Stem cells international 2022;2022:9124277
Stem cells international 2022;2022:9124277
DPSCs Protect Architectural Integrity and Alleviate Intervertebral Disc Degeneration by Regulating Nucleus Pulposus Immune Status.
Dong X, Hu F, Yi J, Zhang Y, Liu C, Geng P, Duan H, Wu CT, Zhang X, Wang H
Stem cells international 2022;2022:7590337
Stem cells international 2022;2022:7590337
Gastrocnemius Muscle Injury Is the Condition to Induce Cartilage Degeneration of the Rabbit Tibiofemoral Joint: A New Perspective.
Li Y, Sun J, Hou Y, Wei J, Chai Y, Zhu X, Wang R
BioMed research international 2022;2022:7532434
BioMed research international 2022;2022:7532434
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Chen J, Cui Z, Wang Y, Lyu L, Feng C, Feng D, Cheng Y, Li Z, Sun S
Oxidative medicine and cellular longevity 2022;2022:3182368
Oxidative medicine and cellular longevity 2022;2022:3182368
Zoledronate promotes ECM degradation and apoptosis via Wnt/β-catenin.
Xiao J, Li Y, Cheng G, Xu G
Open medicine (Warsaw, Poland) 2022;17(1):768-780
Open medicine (Warsaw, Poland) 2022;17(1):768-780
Corosolic Acid Protects Rat Chondrocytes Against IL-1β-Induced ECM Degradation by Activating Autophagy via PI3K/AKT/mTOR Pathway and Ameliorates Rat Osteoarthritis.
Han H, Chen M, Li Z, Zhou S, Wu Y, Wei J
Drug design, development and therapy 2022;16:2627-2637
Drug design, development and therapy 2022;16:2627-2637
3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy.
Tang H, Qin K, Wang A, Li S, Fang S, Gao W, Lu M, Huang W, Zhang H, Yin Z
Frontiers in pharmacology 2022;13:999851
Frontiers in pharmacology 2022;13:999851
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
Shao Y, Sun L, Yang G, Wang W, Liu X, Du T, Chen F, Jing X, Cui X
Frontiers in pharmacology 2022;13:937502
Frontiers in pharmacology 2022;13:937502
Innate/Inflammatory Bioregulation of Surfactant Protein D Alleviates Rat Osteoarthritis by Inhibiting Toll-Like Receptor 4 Signaling.
Jiang H, Zhang Y, Hu G, Shang X, Ming J, Deng M, Li Y, Ma Y, Liu S, Zhou Y
Frontiers in immunology 2022;13:913901
Frontiers in immunology 2022;13:913901
Saikosaponin D Inhibited IL-1β Induced ATDC 5 Chondrocytes Apoptosis In Vitro and Delayed Articular Cartilage Degeneration in OA Model Mice In Vivo.
Wu X, Zhao K, Fang X, Lu F, Cheng P, Song X, Zhang W, Yao C, Zhu J, Chen H
Frontiers in pharmacology 2022;13:845959
Frontiers in pharmacology 2022;13:845959
Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway.
Guo Z, Lin J, Sun K, Guo J, Yao X, Wang G, Hou L, Xu J, Guo J, Guo F
Frontiers in pharmacology 2022;13:791376
Frontiers in pharmacology 2022;13:791376
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Lu R, He Z, Zhang W, Wang Y, Cheng P, Lv Z, Yuan X, Guo F, You H, Chen AM, Hu W
Frontiers in endocrinology 2022;13:1060721
Frontiers in endocrinology 2022;13:1060721
Scutellarin Protects Against Mitochondrial Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation to Attenuate Intervertebral Disc Degeneration.
Wang Z, Zhang P, Zhao Y, Yu F, Wang S, Liu K, Cheng X, Shi J, He Q, Xia Y, Cheng L
Frontiers in bioengineering and biotechnology 2022;10:883118
Frontiers in bioengineering and biotechnology 2022;10:883118
Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes.
Wang W, Jing X, Du T, Ren J, Liu X, Chen F, Shao Y, Sun S, Yang G, Cui X
Free radical biology & medicine 2022 Sep;190:234-246
Free radical biology & medicine 2022 Sep;190:234-246
Omentin-1 promoted proliferation and ameliorated inflammation, apoptosis, and degeneration in human nucleus pulposus cells.
Cabral VLF, Wang F, Peng X, Gao J, Zhou Z, Sun R, Bao J, Wu X
Archives of gerontology and geriatrics 2022 Sep-Oct;102:104748
Archives of gerontology and geriatrics 2022 Sep-Oct;102:104748
Achyranthoside D (AD) improve intervertebral disc degeneration through affect the autophagy and the activation of PI3K/Akt/mTOR pathway.
Zhang C, Li Z, Li L, Li S, Yang L, Chen L, Zhang X, Yang S, Guo Y
Journal of orthopaedic surgery (Hong Kong) 2022 Sep-Dec;30(3):10225536221135474
Journal of orthopaedic surgery (Hong Kong) 2022 Sep-Dec;30(3):10225536221135474
Vasorin-containing small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system.
Liao Z, Ke W, Liu H, Tong B, Wang K, Feng X, Hua W, Wang B, Song Y, Luo R, Liang H, Zhang W, Zhao K, Li S, Yang C
Journal of nanobiotechnology 2022 Sep 19;20(1):420
Journal of nanobiotechnology 2022 Sep 19;20(1):420
Suramin enhances chondrogenic properties by regulating the p67(phox)/PI3K/AKT/SOX9 signalling pathway.
Liu ZM, Shen PC, Lu CC, Chou SH, Tien YC
Bone & joint research 2022 Oct;11(10):723-738
Bone & joint research 2022 Oct;11(10):723-738
Sinensetin attenuates IL-1β-induced cartilage damage and ameliorates osteoarthritis by regulating SERPINA3.
Liu Z, Liu R, Wang R, Dai J, Chen H, Wang J, Li X
Food & function 2022 Oct 3;13(19):9973-9987
Food & function 2022 Oct 3;13(19):9973-9987
Disrupted tenogenesis in masseter as a potential cause of micrognathia.
Liu C, Zhou N, Li N, Xu T, Chen X, Zhou H, Xie A, Liu H, Zhu L, Wang S, Xiao J
International journal of oral science 2022 Oct 18;14(1):50
International journal of oral science 2022 Oct 18;14(1):50
Implementation of Photosensitive, Injectable, Interpenetrating, and Kartogenin-Modified GELMA/PEDGA Biomimetic Scaffolds to Restore Cartilage Integrity in a Full-Thickness Osteochondral Defect Model.
Yu H, Feng M, Mao G, Li Q, Zhang Z, Bian W, Qiu Y
ACS biomaterials science & engineering 2022 Oct 10;8(10):4474-4485
ACS biomaterials science & engineering 2022 Oct 10;8(10):4474-4485
Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes.
Wang X, Liu Z, Peng P, Gong Z, Huang J, Peng H
Chemico-biological interactions 2022 Oct 1;366:110148
Chemico-biological interactions 2022 Oct 1;366:110148
Drugging the circadian clock feedback cycle to ameliorate cartilage degeneration.
He T, Pang S, Wang H, Yun H, Hao X, Jia L, Liu H, Wang D, Wang D, Xu H, Jie Q, Yang L, Zheng C
The FEBS journal 2022 Nov;289(21):6643-6658
The FEBS journal 2022 Nov;289(21):6643-6658
Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages.
Jin Y, Zhang Q, Qin X, Liu Z, Li Z, Zhong X, Xia L, He J, Fang B
Journal of nanobiotechnology 2022 Nov 3;20(1):469
Journal of nanobiotechnology 2022 Nov 3;20(1):469
BAG3 protects chondrocytes against lumbar facet joint osteoarthritis by regulating autophagy and apoptosis.
Lu X, Zhang J, Xue P, Wang Q, Wang X, Sun Y, Cui Z
Journal of physiology and biochemistry 2022 May;78(2):427-437
Journal of physiology and biochemistry 2022 May;78(2):427-437
Endoplasmin regulates differentiation of tonsil-derived mesenchymal stem cells into chondrocytes through ERK signaling.
Kim HR, Choi H, Park SY, Song YC, Kim JH, Shim S, Jun W, Kim KJ, Han J, Chi SW, Leem SH, Chung JW
BMB reports 2022 May;55(5):226-231
BMB reports 2022 May;55(5):226-231
Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis.
Zhang Y, Li S, Jin P, Shang T, Sun R, Lu L, Guo K, Liu J, Tong Y, Wang J, Liu S, Wang C, Kang Y, Zhu W, Wang Q, Zhang X, Yin F, Sun YE, Cui L
Nature communications 2022 May 4;13(1):2447
Nature communications 2022 May 4;13(1):2447
Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats.
Dai WY, Luo ZP
Cellular signalling 2022 Mar;91:110243
Cellular signalling 2022 Mar;91:110243
Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration.
Wang J, Xia D, Lin Y, Xu W, Wu Y, Chen J, Chu J, Shen P, Weng S, Wang X, Shen L, Fan S, Shen S
Experimental & molecular medicine 2022 Mar;54(3):285-297
Experimental & molecular medicine 2022 Mar;54(3):285-297
The anti-inflammation effect of strontium ranelate on rat chondrocytes with or without IL-1β in vitro.
Yu H, Liu Y, Yang X, He J, Zhong Q, Guo X
Experimental and therapeutic medicine 2022 Mar;23(3):208
Experimental and therapeutic medicine 2022 Mar;23(3):208
Mechanical loading mitigates osteoarthritis symptoms by regulating the inflammatory microenvironment in a mouse model.
Zheng W, Li X, Li J, Wang X, Liu D, Zhai L, Ding B, Li G, Sun Y, Yokota H, Zhang P
Annals of the New York Academy of Sciences 2022 Jun;1512(1):141-153
Annals of the New York Academy of Sciences 2022 Jun;1512(1):141-153
Isorhynchophylline ameliorates the progression of osteoarthritis by inhibiting the NF-κB pathway.
Li Z, Shi H, Li Y, Wang W, Li Z, Chen B, Nie D
European journal of pharmacology 2022 Jun 5;924:174971
European journal of pharmacology 2022 Jun 5;924:174971
Upregulation of P2Y12 inhibits chondrocyte apoptosis in lumbar osteoarthritis through the PI3K/AKT signaling pathway.
Wu G, Xue P, Jin H, Zhang M, Gui C, Bao G, Xu G, Jiang J, Zhang J, Cui S, Cui Z, Sun Y
Molecular biology reports 2022 Jul;49(7):6459-6466
Molecular biology reports 2022 Jul;49(7):6459-6466
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
Zhu W, Tang H, Cao L, Zhang J, Li J, Ma D, Guo C
Chemical biology & drug design 2022 Jul;100(1):108-120
Chemical biology & drug design 2022 Jul;100(1):108-120
MMP-10 Deficiency Effects Differentiation and Death of Chondrocytes Associated with Endochondral Osteogenesis in an Endemic Osteoarthritis.
Zhang D, Deng X, Liu Y, Zhang Y, Wang H, Zhang M, Fang Q, Yi C, Zhao X, Ma T, Wu C, Chen J
Cartilage 2022 Jul-Sep;13(3):19476035221109226
Cartilage 2022 Jul-Sep;13(3):19476035221109226
BMSC-derived exosomes promote tendon-bone healing after anterior cruciate ligament reconstruction by regulating M1/M2 macrophage polarization in rats.
Li Z, Li Q, Tong K, Zhu J, Wang H, Chen B, Chen L
Stem cell research & therapy 2022 Jul 15;13(1):295
Stem cell research & therapy 2022 Jul 15;13(1):295
Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1.
Jin Y, Liu Z, Li Z, Li H, Zhu C, Li R, Zhou T, Fang B
International journal of oral science 2022 Jul 14;14(1):34
International journal of oral science 2022 Jul 14;14(1):34
Folic Acid Inhibits Aging-Induced Telomere Attrition and Apoptosis in Astrocytes In Vivo and In Vitro.
Li Z, Zhou D, Zhang D, Zhao J, Li W, Sun Y, Chen Y, Liu H, Wilson JX, Qian Z, Huang G
Cerebral cortex (New York, N.Y. : 1991) 2022 Jan 10;32(2):286-297
Cerebral cortex (New York, N.Y. : 1991) 2022 Jan 10;32(2):286-297
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Wu ZL, Chen YJ, Zhang GZ, Xie QQ, Wang KP, Yang X, Liu TC, Wang ZQ, Zhao GH, Zhang HH
Apoptosis : an international journal on programmed cell death 2022 Feb;27(1-2):133-148
Apoptosis : an international journal on programmed cell death 2022 Feb;27(1-2):133-148
Chondroprotective effects of multiple PRP injections in osteoarthritis by apoptosis regulation and increased aggrecan synthesis- Immunohistochemistry based Guinea pig study.
Patel S, Mishra NP, Chouhan DK, Nahar U, Dhillon MS
Journal of clinical orthopaedics and trauma 2022 Feb;25:101762
Journal of clinical orthopaedics and trauma 2022 Feb;25:101762
A plant-derived natural photosynthetic system for improving cell anabolism.
Chen P, Liu X, Gu C, Zhong P, Song N, Li M, Dai Z, Fang X, Liu Z, Zhang J, Tang R, Fan S, Lin X
Nature 2022 Dec;612(7940):546-554
Nature 2022 Dec;612(7940):546-554
Exosome modification to better alleviates endoplasmic reticulum stress induced chondrocyte apoptosis and osteoarthritis.
Wang Y, Fan A, Lu L, Pan Z, Ma M, Luo S, Liu Z, Yang L, Cai J, Yin F
Biochemical pharmacology 2022 Dec;206:115343
Biochemical pharmacology 2022 Dec;206:115343
Freeze-casting osteochondral scaffolds: The presence of a nutrient-permeable film between the bone and cartilage defect reduces cartilage regeneration.
Chen J, Li Y, Liu S, Du Y, Zhang S, Wang J
Acta biomaterialia 2022 Dec;154:168-179
Acta biomaterialia 2022 Dec;154:168-179
Nodakenin attenuates cartilage degradation and inflammatory responses in a mice model of knee osteoarthritis by regulating mitochondrial Drp1/ROS/NLRP3 axis.
Yi N, Mi Y, Xu X, Li N, Chen B, Yan K, Tan K, Zhang B, Wang L, Kuang G, Lu M
International immunopharmacology 2022 Dec;113(Pt A):109349
International immunopharmacology 2022 Dec;113(Pt A):109349
Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway.
Ma T, Wang X, Qu W, Yang L, Jing C, Zhu B, Zhang Y, Xie W
Molecules (Basel, Switzerland) 2022 Dec 6;27(23)
Molecules (Basel, Switzerland) 2022 Dec 6;27(23)
An Injectable Hydrogel Scaffold Loaded with Dual-Drug/Sustained-Release PLGA Microspheres for the Regulation of Macrophage Polarization in the Treatment of Intervertebral Disc Degeneration.
Cheng H, Guo Q, Zhao H, Liu K, Kang H, Gao F, Guo J, Yuan X, Hu S, Li F, Yang Q, Fang Z
International journal of molecular sciences 2022 Dec 26;24(1)
International journal of molecular sciences 2022 Dec 26;24(1)
Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells.
Chen W, Yasen M, Wang H, Zhuang C, Wang Z, Lu S, Jiang L, Lin H
BMC pharmacology & toxicology 2022 Dec 1;23(1):90
BMC pharmacology & toxicology 2022 Dec 1;23(1):90
Knee Loading Enhances the Migration of Adipose-Derived Stem Cells to the Osteoarthritic Sites Through the SDF-1/CXCR4 Regulatory Axis.
Zhang Y, Li X, Li J, Liu D, Zhai L, Wang X, Abdurahman A, Yokota H, Zhang P
Calcified tissue international 2022 Aug;111(2):171-184
Calcified tissue international 2022 Aug;111(2):171-184
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Zhu W, Tang H, Li J, Guedes RM, Cao L, Guo C
Bioengineered 2022 Apr;13(4):9233-9247
Bioengineered 2022 Apr;13(4):9233-9247
Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis.
Yu H, Li M, Wen X, Yang J, Liang X, Li X, Bao X, Shu J, Ren X, Chen W, Li Z, Li Y
Arthritis research & therapy 2022 Apr 29;24(1):93
Arthritis research & therapy 2022 Apr 29;24(1):93
Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis.
Lin Z, Ni L, Teng C, Zhang Z, Wu L, Jin Y, Lu X, Lin Z
Frontiers in cell and developmental biology 2021;9:745621
Frontiers in cell and developmental biology 2021;9:745621
Reducing Inflammation and Vascular Invasion in Intervertebral Disc Degeneration via Cystathionine-γ-Lyase Inhibitory Effect on E-Selectin.
Xu H, Wei K, Tu J, Chen Y, He Y, Ding Y, Xu H, Bao X, Xie H, Fang H, Wang H
Frontiers in cell and developmental biology 2021;9:741046
Frontiers in cell and developmental biology 2021;9:741046
Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes.
Luo L, Gong J, Zhang H, Qin J, Li C, Zhang J, Tang Y, Zhang Y, Chen J, Zhou Y, Tian Z, Liu Y, Liu M
Frontiers in cell and developmental biology 2021;9:648201
Frontiers in cell and developmental biology 2021;9:648201
Exosomes Isolated From Bone Marrow Mesenchymal Stem Cells Exert a Protective Effect on Osteoarthritis via lncRNA LYRM4-AS1-GRPR-miR-6515-5p.
Wang X, Li Z, Cui Y, Cui X, Chen C, Wang Z
Frontiers in cell and developmental biology 2021;9:644380
Frontiers in cell and developmental biology 2021;9:644380
Single-Cell Profiles of Age-Related Osteoarthritis Uncover Underlying Heterogeneity Associated With Disease Progression.
Liu W, Chen Y, Zeng G, Yang S, Yang T, Ma M, Song W
Frontiers in molecular biosciences 2021;8:748360
Frontiers in molecular biosciences 2021;8:748360
Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.
Liao Z, Li S, Liu R, Feng X, Shi Y, Wang K, Li S, Zhang Y, Wu X, Yang C
Oxidative medicine and cellular longevity 2021;2021:5584447
Oxidative medicine and cellular longevity 2021;2021:5584447
MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis.
Ni B, Pei W, Qu Y, Zhang R, Chu X, Wang Y, Huang X, You H
Oxidative medicine and cellular longevity 2021;2021:4139048
Oxidative medicine and cellular longevity 2021;2021:4139048
Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3.
Jin Y, Li Z, Wu Y, Li H, Liu Z, Liu L, Ouyang N, Zhou T, Fang B, Xia L
Journal of inflammation research 2021;14:6067-6083
Journal of inflammation research 2021;14:6067-6083
Deletion of p16 accelerates fracture healing in geriatric mice.
Ding Q, Liu H, Liu L, Ma C, Qin H, Wei Y, Ren Y
American journal of translational research 2021;13(10):11107-11125
American journal of translational research 2021;13(10):11107-11125
Baicalein Alleviates Osteoarthritis Progression in Mice by Protecting Subchondral Bone and Suppressing Chondrocyte Apoptosis Based on Network Pharmacology.
Yi N, Mi Y, Xu X, Li N, Zeng F, Yan K, Tan K, Kuang G, Lu M
Frontiers in pharmacology 2021;12:788392
Frontiers in pharmacology 2021;12:788392
Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect.
Lu R, Yu X, Liang S, Cheng P, Wang Z, He ZY, Lv ZT, Wan J, Mo H, Zhu WT, Chen AM
Frontiers in pharmacology 2021;12:761922
Frontiers in pharmacology 2021;12:761922
Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development.
Zhou H, Li G, Wang Y, Jiang R, Li Y, Wang H, Wang F, Ma H, Cao L
Frontiers in pharmacology 2021;12:659597
Frontiers in pharmacology 2021;12:659597
Maresin-1 suppresses IL-1β-induced MMP-13 secretion by activating the PI3K/AKT pathway and inhibiting the NF-κB pathway in synovioblasts of an osteoarthritis rat model with treadmill exercise.
Lu J, Feng X, Zhang H, Wei Y, Yang Y, Tian Y, Bai L
Connective tissue research 2021 Sep;62(5):508-518
Connective tissue research 2021 Sep;62(5):508-518
Combination of graphene oxide and platelet-rich plasma improves tendon-bone healing in a rabbit model of supraspinatus tendon reconstruction.
Bao D, Sun J, Gong M, Shi J, Qin B, Deng K, Liu G, Zeng S, Xiang Z, Fu S
Regenerative biomaterials 2021 Oct;8(6):rbab045
Regenerative biomaterials 2021 Oct;8(6):rbab045
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro.
Gao XX, Liu CH, Hu ZL, Li HY, Chang X, Li YY, Zhang YY, Zhai Y, Li CQ
Frontiers in bioscience (Landmark edition) 2021 Oct 30;26(10):799-812
Frontiers in bioscience (Landmark edition) 2021 Oct 30;26(10):799-812
Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis.
Li S, Liu J, Liu S, Jiao W, Wang X
Journal of nanobiotechnology 2021 Oct 26;19(1):343
Journal of nanobiotechnology 2021 Oct 26;19(1):343
SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.
Ding N, Zeng MY, Song WJ, Xiao CX, Li EM, Wei B
Stem cells and development 2021 Oct 15;30(20):1028-1036
Stem cells and development 2021 Oct 15;30(20):1028-1036
Interleukin‑Iβ promotes cartilage degeneration by regulating forkhead box protein O4 and type Ⅱ collagen.
Wu J, Zhang H, Deng R, Xing L, Hu M, Fu X
Molecular medicine reports 2021 Nov;24(5)
Molecular medicine reports 2021 Nov;24(5)
LncRNA NONHSAT030515 promotes the chondrogenic differentiation of human adipose-derived stem cells via regulating the miR-490-5p/BMPR2 axis.
Yang Q, Guo J, Ren Z, Li B, Huang H, Yang Z
Journal of orthopaedic surgery and research 2021 Nov 6;16(1):658
Journal of orthopaedic surgery and research 2021 Nov 6;16(1):658
Hyaluronic acid hydrogel encapsulated BMP-14-modified ADSCs accelerate cartilage defect repair in rabbits.
Liu H, Rui Y, Liu J, Gao F, Jin Y
Journal of orthopaedic surgery and research 2021 Nov 3;16(1):657
Journal of orthopaedic surgery and research 2021 Nov 3;16(1):657
SNHG16/miR-485-5p/BMP7 axis modulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.
Asila A, Yang X, Kaisaer Y, Ma L
The journal of gene medicine 2021 Mar;23(3):e3296
The journal of gene medicine 2021 Mar;23(3):e3296
Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.
Huang H, Liu K, Ou H, Qian X, Wan J
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
Comparison of chondrogenesis-related biological behaviors between human urine-derived stem cells and human bone marrow mesenchymal stem cells from the same individual.
Sun J, Xing F, Zou M, Gong M, Li L, Xiang Z
Stem cell research & therapy 2021 Jun 28;12(1):366
Stem cell research & therapy 2021 Jun 28;12(1):366
Circular RNA circPDE4D Protects against Osteoarthritis by Binding to miR-103a-3p and Regulating FGF18.
Wu Y, Hong Z, Xu W, Chen J, Wang Q, Chen J, Ni W, Mei Z, Xie Z, Ma Y, Wang J, Lu J, Chen C, Fan S, Shen S
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Jan 6;29(1):308-323
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Jan 6;29(1):308-323
Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration.
Guo Z, Qiu C, Mecca C, Zhang Y, Bian J, Wang Y, Wu X, Wang T, Su W, Li X, Zhang W, Chen B, Xiang H
BMC musculoskeletal disorders 2021 Jan 13;22(1):77
BMC musculoskeletal disorders 2021 Jan 13;22(1):77
Silencing BLNK protects against interleukin-1β-induced chondrocyte injury through the NF-κB signaling pathway.
Cheng Y, Li F, Zhang WS, Zou GY, Shen YX
Cytokine 2021 Dec;148:155686
Cytokine 2021 Dec;148:155686
The characterization, cytotoxicity, macrophage response and tissue regeneration of decellularized cartilage in costal cartilage defects.
Changchen W, Hongquan W, Bo Z, Leilei X, Haiyue J, Bo P
Acta biomaterialia 2021 Dec;136:147-158
Acta biomaterialia 2021 Dec;136:147-158
Shockwave Treatment Enhanced Extracellular Matrix Production in Articular Chondrocytes Through Activation of the ROS/MAPK/Nrf2 Signaling Pathway.
Shen PC, Chou SH, Lu CC, Huang HT, Chien SH, Huang PJ, Liu ZM, Shih CL, Su SJ, Chen LM, Tien YC
Cartilage 2021 Dec;13(2_suppl):238S-253S
Cartilage 2021 Dec;13(2_suppl):238S-253S
LncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p/ADAMTS5 pathway.
Long H, Li Q, Xiao Z, Yang B
Bioengineered 2021 Dec;12(1):3148-3158
Bioengineered 2021 Dec;12(1):3148-3158
Role of the hippo signaling pathway in the extracellular matrix degradation of chondrocytes induced by fluoride exposure.
Yu FF, Zuo J, Fu X, Gao MH, Sun L, Yu SY, Li Z, Zhou GY, Ba Y
Ecotoxicology and environmental safety 2021 Dec 1;225:112796
Ecotoxicology and environmental safety 2021 Dec 1;225:112796
Sulforaphane protects against oxidative stress‑induced apoptosis via activating SIRT1 in mouse osteoarthritis.
Chen M, Huang L, Lv Y, Li L, Dong Q
Molecular medicine reports 2021 Aug;24(2)
Molecular medicine reports 2021 Aug;24(2)
ZIP8 mediates the extracellular matrix degradation of nucleus pulposus cells via NF-κB signaling pathway.
Ding W, Ge Y, Sun H, Xu J, Gu H, Bian C, Chen H, Jiang L, Yin X
Biochemical and biophysical research communications 2021 Apr 23;550:30-36
Biochemical and biophysical research communications 2021 Apr 23;550:30-36
Simultaneous Recruitment of Stem Cells and Chondrocytes Induced by a Functionalized Self-Assembling Peptide Hydrogel Improves Endogenous Cartilage Regeneration.
Lv X, Sun C, Hu B, Chen S, Wang Z, Wu Q, Fu K, Xia Z, Shao Z, Wang B
Frontiers in cell and developmental biology 2020;8:864
Frontiers in cell and developmental biology 2020;8:864
OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.
Tian J, Cheng C, Kuang SD, Su C, Zhao X, Xiong YL, Li YS, Gao SG
Pain research & management 2020;2020:3428587
Pain research & management 2020;2020:3428587
Steady Augmentation of Anti-Osteoarthritic Actions of Rapamycin by Liposome-Encapsulation in Collaboration with Low-Intensity Pulsed Ultrasound.
Chen CH, Kuo SM, Tien YC, Shen PC, Kuo YW, Huang HH
International journal of nanomedicine 2020;15:3771-3790
International journal of nanomedicine 2020;15:3771-3790
Matrisome Provides a Supportive Microenvironment for Skin Functions of Diverse Species.
Liu B, Zhang S, Wang W, Yun Z, Lv L, Chai M, Wu Z, Zhu Y, Ma J, Leng L
ACS biomaterials science & engineering 2020 Oct 12;6(10):5720-5733
ACS biomaterials science & engineering 2020 Oct 12;6(10):5720-5733
MSCs reduce airway remodeling in the lungs of asthmatic rats through the Wnt/β-catenin signaling pathway.
Song J, Zhu XM, Wei QY
European review for medical and pharmacological sciences 2020 Nov;24(21):11199-11211
European review for medical and pharmacological sciences 2020 Nov;24(21):11199-11211
Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression.
Zhang X, Huang CR, Pan S, Pang Y, Chen YS, Zha GC, Guo KJ, Zheng X
International immunopharmacology 2020 Jun;83:106425
International immunopharmacology 2020 Jun;83:106425
MicroRNA-675-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GNG5.
Shen XF, Cheng Y, Dong QR, Zheng MQ
Biochemical and biophysical research communications 2020 Jun 25;527(2):458-465
Biochemical and biophysical research communications 2020 Jun 25;527(2):458-465
Sialic acid-modified chitosan oligosaccharide-based biphasic calcium phosphate promote synergetic bone formation in rheumatoid arthritis therapy.
Xu XL, Shu GF, Wang XJ, Qi J, Jin FY, Shen QY, Ying XY, Ji JS, Du YZ
Journal of controlled release : official journal of the Controlled Release Society 2020 Jul 10;323:578-590
Journal of controlled release : official journal of the Controlled Release Society 2020 Jul 10;323:578-590
L-polylactic acid porous microspheres enhance the mechanical properties and in vivo stability of degummed silk/silk fibroin/gelatin scaffold.
Li T, Liu B, Jiang Y, Lou Y, Chen K, Zhang D
Biomedical materials (Bristol, England) 2020 Dec 17;16(1):015025
Biomedical materials (Bristol, England) 2020 Dec 17;16(1):015025
Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice.
Wang W, Yang R, Zhang M, Li J, Peng J, Xu M, Zhao Y, Li H, Pan X
Inflammation 2020 Aug;43(4):1312-1322
Inflammation 2020 Aug;43(4):1312-1322
p-Coumaric Acid Attenuates IL-1β-Induced Inflammatory Responses and Cellular Senescence in Rat Chondrocytes.
Huang X, You Y, Xi Y, Ni B, Chu X, Zhang R, You H
Inflammation 2020 Apr;43(2):619-628
Inflammation 2020 Apr;43(2):619-628
Overexpression of miR-10a-5p facilitates the progression of osteoarthritis.
Li HZ, Xu XH, Lin N, Wang DW, Lin YM, Su ZZ, Lu HD
Aging 2020 Apr 13;12(7):5948-5976
Aging 2020 Apr 13;12(7):5948-5976
MicroRNA-132 upregulation promotes matrix degradation in intervertebral disc degeneration.
Liu W, Xia P, Feng J, Kang L, Huang M, Wang K, Song Y, Li S, Wu X, Yang S, Yang C
Experimental cell research 2017 Oct 1;359(1):39-49
Experimental cell research 2017 Oct 1;359(1):39-49
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Tu J, Li W, Zhang Y, Wu X, Song Y, Kang L, Liu W, Wang K, Li S, Hua W, Yang C
Inflammation 2017 Jun;40(3):725-734
Inflammation 2017 Jun;40(3):725-734
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