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- Antigen structure
- References [223]
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- Product number
- 28459-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- Collagen Type II antibody
- Antibody type
- Polyclonal
- Description
- Collagen Type II antibody (Cat. #28459-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human and has been validated for the following applications: IHC,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Protective effects of ectoine on articular chondrocytes and cartilage in rats for treating osteoarthritis.
Role of integrin β1 and tenascin C mediate TGF-SMAD2/3 signaling in chondrogenic differentiation of BMSCs induced by type I collagen hydrogel.
ROS-Responsive Injectable Hydrogel Loaded with SLC7A11-modRNA Inhibits Ferroptosis and Mitigates Intervertebral Disc Degeneration in Rats.
Anti-Stress and Anti-ROS Effects of MnOx-Functionalized Thermosensitive Nanohydrogel Protect BMSCs for Intervertebral Disc Degeneration Repair.
Development of alginate-collagen interpenetrating network for osteoarthritic cartilage by in situ softening.
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.
Genkwanin alleviates intervertebral disc degeneration via regulating ITGA2/PI3K/AKT pathway and inhibiting apoptosis and senescence.
Chondroprotective effects of Apolipoprotein D in knee osteoarthritis mice through the PI3K/AKT/mTOR signaling pathway.
Targeting the HSP47-collagen axis inhibits brain metastasis by reversing M2 microglial polarization and restoring anti-tumor immunity.
Engineered Exosomes with ATF5-Modified mRNA Loaded in Injectable Thermogels Alleviate Osteoarthritis by Targeting the Mitochondrial Unfolded Protein Response.
Inhibition of SAT1 alleviates chondrocyte inflammation and ferroptosis by repressing ALOX15 expression and activating the Nrf2 pathway.
Peptide-Based Hydrogel Scaffold Facilitates Articular Cartilage Damage Repair.
SIRT3 alleviates high glucose-induced chondrocyte injury through the promotion of autophagy and suppression of apoptosis in osteoarthritis progression.
Gentiopicroside ameliorates the lipopolysaccharide-induced inflammatory response and hypertrophy in chondrocytes.
Circular RNA CircFOXO3 Functions as a Competitive Endogenous RNA for Acid-Sensing Ion Channel Subunit 1 Mediating Oxeiptosis in Nucleus Pulposus.
TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis.
Low-intensity pulsed ultrasound delays the progression of osteoarthritis by regulating the YAP-RIPK1-NF-κB axis and influencing autophagy.
Atractylenolide-III attenuates osteoarthritis by repolarizing macrophages through inactivating TLR4/NF-κB signaling.
Moderate mechanical stress suppresses chondrocyte ferroptosis in osteoarthritis by regulating NF-κB p65/GPX4 signaling pathway.
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy.
Astaxanthin reduces inflammation and promotes a chondrogenic phenotype by upregulating SIRT1 in osteoarthritis.
A natural hydrogel complex improves intervertebral disc degeneration by correcting fatty acid metabolism and inhibiting nucleus pulposus cell pyroptosis.
A multifunctional nanogel encapsulating layered double hydroxide for enhanced osteoarthritis treatment via protection of chondrocytes and ECM.
Botulinum toxin A attenuates osteoarthritis development via inhibiting chondrocyte ferroptosis through SLC7Al1/GPX4 axis.
MMP13-targeted siRNA-loaded micelles for diagnosis and treatment of posttraumatic osteoarthritis.
Activation of Notch Signaling Pathway is involved in Extracellular Matrix Degradation in human induced pluripotent stem cells chondrocytes induced by HT-2 toxin.
The Combined Intraosseous Administration of Orthobiologics Outperformed Isolated Intra-articular Injections in Alleviating Pain and Cartilage Degeneration in a Rat Model of MIA-Induced Knee Osteoarthritis.
Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway.
Exercise-induced modulation of myokine irisin on muscle-bone unit in the rat model of post-traumatic osteoarthritis.
Carveol alleviates osteoarthritis progression by acting on synovial macrophage polarization transformation: An in vitro and in vivo study.
COL3A1 is a potential diagnostic biomarker for synovial chondromatosis and affects the cell cycle and migration of chondrocytes.
Calycosin ameliorates osteoarthritis by regulating the imbalance between chondrocyte synthesis and catabolism.
The CREB1 inhibitor 666-15 maintains cartilage homeostasis and mitigates osteoarthritis progression.
Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
FOXO3-Activated HOTTIP Sequesters miR-615-3p away from COL2A1 to Mitigate Intervertebral Disc Degeneration.
Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6.
P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability.
SYNJ2BP ameliorates intervertebral disc degeneration by facilitating mitochondria-associated endoplasmic reticulum membrane formation and mitochondrial Zn(2+) homeostasis.
Diatomite-incorporated hierarchical scaffolds for osteochondral regeneration.
Degrasyn alleviates osteoarthritis by blocking macrophagic pyroptosis via suppressing NLRP3/GSDMD signaling pathway and protecting chondrocytes.
Injectable Microgels with Hybrid Exosomes of Chondrocyte-Targeted FGF18 Gene-Editing and Self-Renewable Lubrication for Osteoarthritis Therapy.
Injectable pathological microenvironment-responsive anti-inflammatory hydrogels for ameliorating intervertebral disc degeneration.
Injectable silk fibroin peptide nanofiber hydrogel composite scaffolds for cartilage regeneration.
The NLRX1-SLC39A7 complex orchestrates mitochondrial dynamics and mitophagy to rejuvenate intervertebral disc by modulating mitochondrial Zn(2+) trafficking.
Spermidine ameliorates osteoarthritis via altering macrophage polarization.
Tenascin-C promotes endochondral ossification and fracture healing through Hedgehog and Hippo signaling.
CARMA3 Drives NF-κB Activation and Promotes Intervertebral Disc Degeneration: Involvement of CARMA3-BCL10-MALT1 Signalosome.
miR-1 Inhibits the Ferroptosis of Chondrocyte by Targeting CX43 and Alleviates Osteoarthritis Progression.
Pioglitazone-Loaded Cartilage-Targeted Nanomicelles (Pio@C-HA-DOs) for Osteoarthritis Treatment.
The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies.
Therapeutic Effect of Acupotomy at Sanheyang for Cartilage Collagen Damage in Moderate Knee Osteoarthritis: A Rabbit Model.
Digoxin protects against intervertebral disc degeneration via TNF/NF-κB and LRP4 signaling.
Microtubule stabilization promotes the synthesis of type 2 collagen in nucleus pulposus cell by activating hippo-yap pathway.
Overexpression of fibroblast growth factor receptor 2 in bone marrow mesenchymal stem cells enhances osteogenesis and promotes critical cranial bone defect regeneration.
Quiescence preconditioned nucleus pulposus stem cells alleviate intervertebral disc degeneration by enhancing cell survival via adaptive metabolism pattern in rats.
Identification of EGFR as an essential regulator in chondrocytes ferroptosis of osteoarthritis using bioinformatics, in vivo, and in vitro study.
Donor-Matched Peripheral Blood-Derived Mesenchymal Stem Cells Combined With Platelet-Rich Plasma Synergistically Ameliorate Surgery-Induced Osteoarthritis in Rabbits: An In Vitro and In Vivo Study.
Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages.
Function and regulation of nuclear factor 1 X-type on chondrocyte proliferation and differentiation.
Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis.
TGF-β1 Triggers Salivary Hypofunction via Attenuating Protein Secretion and AQP5 Expression in Human Submandibular Gland Cells.
Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF‑κB and MAPK signalling transduction through integrin αVβ3.
An in vitro and in vivo study: Valencene protects cartilage and alleviates the progression of osteoarthritis by anti-oxidative stress and anti-inflammatory effects.
Exploring the chondroprotective effect of Chaenomeles speciosa on Glucose-6-Phosphate Isomerase model mice using an integrated approach of network pharmacology and experimental validation.
Focused low-intensity pulsed ultrasound alleviates osteoarthritis via restoring impaired FUNDC1-mediated mitophagy.
Pentraxin 3 deficiency ameliorates the severity of osteoarthritis and alleviates inflammation.
Dapagliflozin suppress endoplasmic reticulum stress mediated apoptosis of chondrocytes by activating Sirt1.
α-Ketoglutaric acid ameliorates intervertebral disk degeneration by blocking the IL-6/JAK2/STAT3 pathway.
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death.
Activation of the Nrf-2 pathway by pinocembrin safeguards vertebral endplate chondrocytes against apoptosis and degeneration caused by oxidative stress.
BSHXF-medicated serum combined with ADSCs regulates the TGF-β1/Smad pathway to repair oxidatively damaged NPCs and its component analysis.
Sophisticated Magneto-Mechanical Actuation Promotes In Situ Stem Cell Assembly and Chondrogenesis for Treating Osteoarthritis.
A20 ameliorates disc degeneration by suppressing mTOR/BNIP3 axis-mediated mitophagy.
Integrin expression and extracellular matrix adhesion of septoclasts, pericytes, and endothelial cells at the chondro-osseous junction and the metaphysis of the proximal tibia in young mice.
The Bcr-Abl inhibitor DCC-2036 inhibits necroptosis and ameliorates osteoarthritis by targeting RIPK1 and RIPK3 kinases.
BuShen JianGu Fang alleviates cartilage degeneration via regulating multiple genes and signaling pathways to activate NF-κB/Sox9 axis.
An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment.
Polydopamine-Pd nanozymes as potent ROS scavengers in combination with near-infrared irradiation for osteoarthritis treatment.
Preparation of Melatonin-Loaded Nanoparticles with Targeting and Sustained Release Function and Their Application in Osteoarthritis.
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
METTL3 promotes SMSCs chondrogenic differentiation by targeting the MMP3, MMP13, and GATA3.
An esterase-responsive ibuprofen nano-micelle pre-modified embryo derived nucleus pulposus progenitor cells promote the regeneration of intervertebral disc degeneration.
PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway.
Thermosensitive hydrogel for cartilage regeneration via synergistic delivery of SDF-1α like polypeptides and kartogenin.
Experimental study of miR-503 regulating the activity as well as the function of degenerated human nucleus pulposus cells of the intervertebral disc through inhibiting Wnt pathway.
A comprehensive analysis of single-cell RNA transcriptome reveals unique SPP1+ chondrocytes in human osteoarthritis.
Stevioside protects primary articular chondrocytes against IL-1β-induced inflammation and catabolism by targeting integrin.
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway.
tsRNA-04002 alleviates intervertebral disk degeneration by targeting PRKCA to inhibit apoptosis of nucleus pulposus cells.
Du Huo Ji Sheng Tang inhibits Notch1 signaling and subsequent NLRP3 activation to alleviate cartilage degradation in KOA mice.
Wound Gel with Antimicrobial Effects Based on Polyvinyl Alcohol and Functional Aryloxycyclotriphosphazene.
TNF-α activates RELA expression via TNFRSF1B to upregulate OPA1 expression and inhibit chondrogenic differentiation of human adipose stem cells.
EIF4A3-Induced Upregulation of hsa_circ_0040039 is a Biomarker and Aggravates IL-1β-Stimulated Intervertebral Disc Degeneration.
Activating Mitochondrial Sirtuin 3 in Chondrocytes Alleviates Aging-Induced Fibrocartilage Layer Degeneration and Promotes Healing of Degenerative Rotator Cuff Injury.
Exosomal miR-429 derived from adipose-derived stem cells ameliorated chondral injury in osteoarthritis via autophagy by targeting FEZ2.
Targeting macrophagic PIM-1 alleviates osteoarthritis by inhibiting NLRP3 inflammasome activation via suppressing mitochondrial ROS/Cl(-) efflux signaling pathway.
Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy.
Pelargonidin ameliorates inflammatory response and cartilage degeneration in osteoarthritis via suppressing the NF-κB pathway.
Novel insights into the effect of deer IGF-1 on chondrocyte viability and IL-1β-induced inflammation response.
Activation of the kynurenine-aryl hydrocarbon receptor axis impairs the chondrogenic and chondroprotective effects of human umbilical cord-derived mesenchymal stromal cells in osteoarthritis rats.
Increased FGFR3 is involved in T-2 toxin-induced lesions of hypertrophic cartilage associated with endemic osteoarthritis.
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.
Hypoxia-Inducible Factor-1α Protects Against Intervertebral Disc Degeneration Through Antagonizing Mitochondrial Oxidative Stress.
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Indirubin protects chondrocytes and alleviates OA by inhibiting the MAPK and NF-κB pathways.
Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways.
Astaxanthin Promotes the Survival of Adipose-Derived Stem Cells by Alleviating Oxidative Stress via Activating the Nrf2 Signaling Pathway.
Hypoxia dissociates HDAC6/FOXO1 complex and aggregates them into nucleus to regulate autophagy and osteogenic differentiation.
Tranexamic Acid Causes Chondral Injury Through Chondrocytes Apoptosis Induced by Activating Endoplasmic Reticulum Stress.
Enhancement and Repair of Degenerative Intervertebral Disc in Rats Using Platelet-Rich Plasma/Ferulic Acid Hydrogel.
Cabozantinib prevents AGEs-induced degradation of type 2 collagen and aggrecan in human chondrocytes.
MiR-146b-5p enriched bioinspired exosomes derived from fucoidan-directed induction mesenchymal stem cells protect chondrocytes in osteoarthritis by targeting TRAF6.
Growth differentiation factor 5 inhibits lipopolysaccharide-mediated pyroptosis of nucleus pulposus mesenchymal stem cells via RhoA signaling pathway.
Ginsenoside compound K alleviates osteoarthritis by inhibiting NLRP3‑mediated pyroptosis.
Exosomes derived from bone marrow mesenchymal stem cells pretreated with decellularized extracellular matrix enhance the alleviation of osteoarthritis through miR-3473b/phosphatase and tensin homolog axis.
ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-κB signaling pathway.
ADRM1/RPN13 attenuates cartilage extracellular matrix degradation via enhancing UCH37-mediated ALK5 deubiquitination.
Injectable photocrosslinking spherical hydrogel-encapsulated targeting peptide-modified engineered exosomes for osteoarthritis therapy.
Kartogenin-loaded hydrogel promotes intervertebral disc repair via protecting MSCs against reactive oxygen species microenvironment by Nrf2/TXNIP/NLRP3 axis.
Piezo1-mediated mechanotransduction promotes entheseal pathological new bone formation in ankylosing spondylitis.
Comparative transcriptome analysis provides insight into the molecular targets and signaling pathways of deer TGF-1 regulating chondrocytes proliferation and differentiation.
Withdrawn: X. Chen, Y. Li, M. Zhang, X. Wu, J. Zhu. Silencing LCK inactivates the NF-κB pathway to attenuate cartilage injury in osteoarthritis: An in vivo and in vitro study, published in The Journal of Gene Medicine.
The journal of gene medicine 2023 Apr;25(4):e3387
Lithium-Containing Biomaterials Stimulate Cartilage Repair through Bone Marrow Stromal Cells-Derived Exosomal miR-455-3p and Histone H3 Acetylation.
Integrated Cascade Nanozyme Remodels Chondrocyte Inflammatory Microenvironment in Temporomandibular Joint Osteoarthritis via Inhibiting ROS-NF-κB and MAPK Pathways.
Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways.
Structural and biofunctional evaluation of decellularized jellyfish matrices.
BRD4 Inhibition Suppresses Senescence and Apoptosis of Nucleus Pulposus Cells by Inducing Autophagy during Intervertebral Disc Degeneration: An In Vitro and In Vivo Study.
Scrapie-Responsive Gene 1 Promotes Chondrogenic Differentiation of Umbilical Cord Mesenchymal Stem Cells via Wnt5a.
DPSCs Protect Architectural Integrity and Alleviate Intervertebral Disc Degeneration by Regulating Nucleus Pulposus Immune Status.
Gastrocnemius Muscle Injury Is the Condition to Induce Cartilage Degeneration of the Rabbit Tibiofemoral Joint: A New Perspective.
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Zoledronate promotes ECM degradation and apoptosis via Wnt/β-catenin.
Corosolic Acid Protects Rat Chondrocytes Against IL-1β-Induced ECM Degradation by Activating Autophagy via PI3K/AKT/mTOR Pathway and Ameliorates Rat Osteoarthritis.
3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy.
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
Innate/Inflammatory Bioregulation of Surfactant Protein D Alleviates Rat Osteoarthritis by Inhibiting Toll-Like Receptor 4 Signaling.
Saikosaponin D Inhibited IL-1β Induced ATDC 5 Chondrocytes Apoptosis In Vitro and Delayed Articular Cartilage Degeneration in OA Model Mice In Vivo.
Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway.
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Scutellarin Protects Against Mitochondrial Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation to Attenuate Intervertebral Disc Degeneration.
Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes.
Omentin-1 promoted proliferation and ameliorated inflammation, apoptosis, and degeneration in human nucleus pulposus cells.
Achyranthoside D (AD) improve intervertebral disc degeneration through affect the autophagy and the activation of PI3K/Akt/mTOR pathway.
Vasorin-containing small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system.
Suramin enhances chondrogenic properties by regulating the p67(phox)/PI3K/AKT/SOX9 signalling pathway.
Sinensetin attenuates IL-1β-induced cartilage damage and ameliorates osteoarthritis by regulating SERPINA3.
Disrupted tenogenesis in masseter as a potential cause of micrognathia.
Implementation of Photosensitive, Injectable, Interpenetrating, and Kartogenin-Modified GELMA/PEDGA Biomimetic Scaffolds to Restore Cartilage Integrity in a Full-Thickness Osteochondral Defect Model.
Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes.
Drugging the circadian clock feedback cycle to ameliorate cartilage degeneration.
Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages.
BAG3 protects chondrocytes against lumbar facet joint osteoarthritis by regulating autophagy and apoptosis.
Endoplasmin regulates differentiation of tonsil-derived mesenchymal stem cells into chondrocytes through ERK signaling.
Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis.
Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats.
Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration.
The anti-inflammation effect of strontium ranelate on rat chondrocytes with or without IL-1β in vitro.
Mechanical loading mitigates osteoarthritis symptoms by regulating the inflammatory microenvironment in a mouse model.
Isorhynchophylline ameliorates the progression of osteoarthritis by inhibiting the NF-κB pathway.
Upregulation of P2Y12 inhibits chondrocyte apoptosis in lumbar osteoarthritis through the PI3K/AKT signaling pathway.
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
MMP-10 Deficiency Effects Differentiation and Death of Chondrocytes Associated with Endochondral Osteogenesis in an Endemic Osteoarthritis.
BMSC-derived exosomes promote tendon-bone healing after anterior cruciate ligament reconstruction by regulating M1/M2 macrophage polarization in rats.
Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1.
Folic Acid Inhibits Aging-Induced Telomere Attrition and Apoptosis in Astrocytes In Vivo and In Vitro.
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Chondroprotective effects of multiple PRP injections in osteoarthritis by apoptosis regulation and increased aggrecan synthesis- Immunohistochemistry based Guinea pig study.
A plant-derived natural photosynthetic system for improving cell anabolism.
Exosome modification to better alleviates endoplasmic reticulum stress induced chondrocyte apoptosis and osteoarthritis.
Freeze-casting osteochondral scaffolds: The presence of a nutrient-permeable film between the bone and cartilage defect reduces cartilage regeneration.
Nodakenin attenuates cartilage degradation and inflammatory responses in a mice model of knee osteoarthritis by regulating mitochondrial Drp1/ROS/NLRP3 axis.
Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway.
An Injectable Hydrogel Scaffold Loaded with Dual-Drug/Sustained-Release PLGA Microspheres for the Regulation of Macrophage Polarization in the Treatment of Intervertebral Disc Degeneration.
Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells.
Knee Loading Enhances the Migration of Adipose-Derived Stem Cells to the Osteoarthritic Sites Through the SDF-1/CXCR4 Regulatory Axis.
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis.
Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis.
Reducing Inflammation and Vascular Invasion in Intervertebral Disc Degeneration via Cystathionine-γ-Lyase Inhibitory Effect on E-Selectin.
Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes.
Exosomes Isolated From Bone Marrow Mesenchymal Stem Cells Exert a Protective Effect on Osteoarthritis via lncRNA LYRM4-AS1-GRPR-miR-6515-5p.
Single-Cell Profiles of Age-Related Osteoarthritis Uncover Underlying Heterogeneity Associated With Disease Progression.
Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.
MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis.
Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3.
Deletion of p16 accelerates fracture healing in geriatric mice.
Baicalein Alleviates Osteoarthritis Progression in Mice by Protecting Subchondral Bone and Suppressing Chondrocyte Apoptosis Based on Network Pharmacology.
Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect.
Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development.
Maresin-1 suppresses IL-1β-induced MMP-13 secretion by activating the PI3K/AKT pathway and inhibiting the NF-κB pathway in synovioblasts of an osteoarthritis rat model with treadmill exercise.
Combination of graphene oxide and platelet-rich plasma improves tendon-bone healing in a rabbit model of supraspinatus tendon reconstruction.
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro.
Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis.
SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.
Interleukin‑Iβ promotes cartilage degeneration by regulating forkhead box protein O4 and type Ⅱ collagen.
LncRNA NONHSAT030515 promotes the chondrogenic differentiation of human adipose-derived stem cells via regulating the miR-490-5p/BMPR2 axis.
Hyaluronic acid hydrogel encapsulated BMP-14-modified ADSCs accelerate cartilage defect repair in rabbits.
SNHG16/miR-485-5p/BMP7 axis modulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.
Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.
Comparison of chondrogenesis-related biological behaviors between human urine-derived stem cells and human bone marrow mesenchymal stem cells from the same individual.
Circular RNA circPDE4D Protects against Osteoarthritis by Binding to miR-103a-3p and Regulating FGF18.
Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration.
Silencing BLNK protects against interleukin-1β-induced chondrocyte injury through the NF-κB signaling pathway.
The characterization, cytotoxicity, macrophage response and tissue regeneration of decellularized cartilage in costal cartilage defects.
Shockwave Treatment Enhanced Extracellular Matrix Production in Articular Chondrocytes Through Activation of the ROS/MAPK/Nrf2 Signaling Pathway.
LncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p/ADAMTS5 pathway.
Role of the hippo signaling pathway in the extracellular matrix degradation of chondrocytes induced by fluoride exposure.
Sulforaphane protects against oxidative stress‑induced apoptosis via activating SIRT1 in mouse osteoarthritis.
ZIP8 mediates the extracellular matrix degradation of nucleus pulposus cells via NF-κB signaling pathway.
Simultaneous Recruitment of Stem Cells and Chondrocytes Induced by a Functionalized Self-Assembling Peptide Hydrogel Improves Endogenous Cartilage Regeneration.
OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.
Steady Augmentation of Anti-Osteoarthritic Actions of Rapamycin by Liposome-Encapsulation in Collaboration with Low-Intensity Pulsed Ultrasound.
Matrisome Provides a Supportive Microenvironment for Skin Functions of Diverse Species.
MSCs reduce airway remodeling in the lungs of asthmatic rats through the Wnt/β-catenin signaling pathway.
Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression.
MicroRNA-675-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GNG5.
Sialic acid-modified chitosan oligosaccharide-based biphasic calcium phosphate promote synergetic bone formation in rheumatoid arthritis therapy.
L-polylactic acid porous microspheres enhance the mechanical properties and in vivo stability of degummed silk/silk fibroin/gelatin scaffold.
Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice.
p-Coumaric Acid Attenuates IL-1β-Induced Inflammatory Responses and Cellular Senescence in Rat Chondrocytes.
Overexpression of miR-10a-5p facilitates the progression of osteoarthritis.
MicroRNA-132 upregulation promotes matrix degradation in intervertebral disc degeneration.
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Li P, Huang Y, Miao L, Zhu Z, Shi Z
PloS one 2024;19(2):e0299351
PloS one 2024;19(2):e0299351
Role of integrin β1 and tenascin C mediate TGF-SMAD2/3 signaling in chondrogenic differentiation of BMSCs induced by type I collagen hydrogel.
Huang Y, Sun M, Lu Z, Zhong Q, Tan M, Wei Q, Zheng L
Regenerative biomaterials 2024;11:rbae017
Regenerative biomaterials 2024;11:rbae017
ROS-Responsive Injectable Hydrogel Loaded with SLC7A11-modRNA Inhibits Ferroptosis and Mitigates Intervertebral Disc Degeneration in Rats.
Gao T, Xu G, Ma T, Lu X, Chen K, Luo H, Chen G, Song J, Ma X, Fu W, Zheng C, Xia X, Jiang J
Advanced healthcare materials 2024 Oct;13(27):e2401103
Advanced healthcare materials 2024 Oct;13(27):e2401103
Anti-Stress and Anti-ROS Effects of MnOx-Functionalized Thermosensitive Nanohydrogel Protect BMSCs for Intervertebral Disc Degeneration Repair.
Wang X, Yu L, Duan J, Chang M, Hao M, Xiang Z, Qiu C, Sun J, Di D, Xia H, Li D, Yuan S, Tian Y, Qiu J, Liu H, Liu X, Sang Y, Wang L
Advanced healthcare materials 2024 Nov;13(29):e2400343
Advanced healthcare materials 2024 Nov;13(29):e2400343
Development of alginate-collagen interpenetrating network for osteoarthritic cartilage by in situ softening.
Du G, Zhang J, Shuai Q, Li L, Zhang Q, Shi R
International journal of biological macromolecules 2024 May;266(Pt 2):131259
International journal of biological macromolecules 2024 May;266(Pt 2):131259
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.
Dong ZL, Jiao X, Wang ZG, Yuan K, Yang YQ, Wang Y, Li YT, Wang TC, Kan TY, Wang J, Tao HR
Military Medical Research 2024 May 6;11(1):28
Military Medical Research 2024 May 6;11(1):28
Genkwanin alleviates intervertebral disc degeneration via regulating ITGA2/PI3K/AKT pathway and inhibiting apoptosis and senescence.
Li M, Yu X, Chen X, Jiang Y, Zeng Y, Ren R, Nie M, Zhang Z, Bao Y, Kang H
International immunopharmacology 2024 May 30;133:112101
International immunopharmacology 2024 May 30;133:112101
Chondroprotective effects of Apolipoprotein D in knee osteoarthritis mice through the PI3K/AKT/mTOR signaling pathway.
Zhang G, Huang C, Wang R, Guo J, Qin Y, Lv S
International immunopharmacology 2024 May 30;133:112005
International immunopharmacology 2024 May 30;133:112005
Targeting the HSP47-collagen axis inhibits brain metastasis by reversing M2 microglial polarization and restoring anti-tumor immunity.
Wang L, Li C, Zhan H, Li S, Zeng K, Xu C, Zou Y, Xie Y, Zhan Z, Yin S, Zeng Y, Chen X, Lv G, Han Z, Zhou D, Zhou D, Yang Y, Zhou A
Cell reports. Medicine 2024 May 21;5(5):101533
Cell reports. Medicine 2024 May 21;5(5):101533
Engineered Exosomes with ATF5-Modified mRNA Loaded in Injectable Thermogels Alleviate Osteoarthritis by Targeting the Mitochondrial Unfolded Protein Response.
Ma T, Xu G, Gao T, Zhao G, Huang G, Shi J, Chen J, Song J, Xia J, Ma X
ACS applied materials & interfaces 2024 May 1;16(17):21383-21399
ACS applied materials & interfaces 2024 May 1;16(17):21383-21399
Inhibition of SAT1 alleviates chondrocyte inflammation and ferroptosis by repressing ALOX15 expression and activating the Nrf2 pathway.
Xu J, Ruan Z, Guo Z, Hou L, Wang G, Zheng Z, Zhang X, Liu H, Sun K, Guo F
Bone & joint research 2024 Mar 7;13(3):110-123
Bone & joint research 2024 Mar 7;13(3):110-123
Peptide-Based Hydrogel Scaffold Facilitates Articular Cartilage Damage Repair.
Chen C, Wu D, Wang Z, Liu L, He J, Li J, Chu B, Wang S, Yu B, Liu W
ACS applied materials & interfaces 2024 Mar 6;16(9):11336-11348
ACS applied materials & interfaces 2024 Mar 6;16(9):11336-11348
SIRT3 alleviates high glucose-induced chondrocyte injury through the promotion of autophagy and suppression of apoptosis in osteoarthritis progression.
Wang X, Liu Z, Deng S, Zhou J, Li X, Huang J, Chen J, Ji C, Deng Y, Hu Y
International immunopharmacology 2024 Mar 30;130:111755
International immunopharmacology 2024 Mar 30;130:111755
Gentiopicroside ameliorates the lipopolysaccharide-induced inflammatory response and hypertrophy in chondrocytes.
Li L, Fan Q, Zhao Y, Zhang Q, Qin G, Li C, Li W
Journal of orthopaedic surgery and research 2024 Mar 25;19(1):198
Journal of orthopaedic surgery and research 2024 Mar 25;19(1):198
Circular RNA CircFOXO3 Functions as a Competitive Endogenous RNA for Acid-Sensing Ion Channel Subunit 1 Mediating Oxeiptosis in Nucleus Pulposus.
Chen X, Song Y, Chen G, Zhang B, Bai Y, Sun C, Fan D, Chen Z
Biomedicines 2024 Mar 18;12(3)
Biomedicines 2024 Mar 18;12(3)
TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis.
Wang W, Ma Z, Feng X, Ren J, Sun S, Shao Y, Zhang W, Yang X, Zhang J, Jing X
Arthritis research & therapy 2024 Mar 16;26(1):71
Arthritis research & therapy 2024 Mar 16;26(1):71
Low-intensity pulsed ultrasound delays the progression of osteoarthritis by regulating the YAP-RIPK1-NF-κB axis and influencing autophagy.
Pan C, Lu F, Hao X, Deng X, Liu J, Sun K, Hou W, Shang X, Chi R, Guo F, Xu T
Journal of translational medicine 2024 Mar 16;22(1):286
Journal of translational medicine 2024 Mar 16;22(1):286
Atractylenolide-III attenuates osteoarthritis by repolarizing macrophages through inactivating TLR4/NF-κB signaling.
Yi G, Zhang R, Li M, Song X, Li S
International immunopharmacology 2024 Mar 10;129:111629
International immunopharmacology 2024 Mar 10;129:111629
Moderate mechanical stress suppresses chondrocyte ferroptosis in osteoarthritis by regulating NF-κB p65/GPX4 signaling pathway.
Han J, Zhan LN, Huang Y, Guo S, Zhou X, Kapilevich L, Wang Z, Ning K, Sun M, Zhang XA
Scientific reports 2024 Mar 1;14(1):5078
Scientific reports 2024 Mar 1;14(1):5078
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy.
Xu T, Zhao H, Li J, Fang X, Wu H, Hu W
JOR spine 2024 Jun;7(2):e1325
JOR spine 2024 Jun;7(2):e1325
Astaxanthin reduces inflammation and promotes a chondrogenic phenotype by upregulating SIRT1 in osteoarthritis.
Qin H, Liu X, Ding Q, Liu H, Ma C, Wei Y, Lv Y, Wang S, Ren Y
The Knee 2024 Jun;48:83-93
The Knee 2024 Jun;48:83-93
A natural hydrogel complex improves intervertebral disc degeneration by correcting fatty acid metabolism and inhibiting nucleus pulposus cell pyroptosis.
Wang D, Zhang L, He D, Zhang Y, Zhao L, Miao Z, Cheng W, Zhu C, Shao Y, Ge G, Zhu H, Jin H, Zhang W, Pan H
Materials today. Bio 2024 Jun;26:101081
Materials today. Bio 2024 Jun;26:101081
A multifunctional nanogel encapsulating layered double hydroxide for enhanced osteoarthritis treatment via protection of chondrocytes and ECM.
Liu C, Sun Y, Li D, Wang F, Wang H, An S, Sun S
Materials today. Bio 2024 Jun;26:101034
Materials today. Bio 2024 Jun;26:101034
Botulinum toxin A attenuates osteoarthritis development via inhibiting chondrocyte ferroptosis through SLC7Al1/GPX4 axis.
Zeng L, Liu Y, Wang Q, Wan H, Meng X, Tu P, Chen H, Luo A, Hu P, Ding X
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167215
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167215
MMP13-targeted siRNA-loaded micelles for diagnosis and treatment of posttraumatic osteoarthritis.
Zhou D, Wei Y, Sheng S, Wang M, Lv J, Zhao B, Chen X, Xu K, Bai L, Wu Y, Song P, Cao L, Zhou F, Zhang H, Shi Z, Su J
Bioactive materials 2024 Jul;37:378-392
Bioactive materials 2024 Jul;37:378-392
Activation of Notch Signaling Pathway is involved in Extracellular Matrix Degradation in human induced pluripotent stem cells chondrocytes induced by HT-2 toxin.
Meng P, Liu H, Liu L, Wen Y, Zhang F, Zhang Y, Jia Y, Zhang Y, Zhang F, Guo X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Jul;189:114724
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Jul;189:114724
The Combined Intraosseous Administration of Orthobiologics Outperformed Isolated Intra-articular Injections in Alleviating Pain and Cartilage Degeneration in a Rat Model of MIA-Induced Knee Osteoarthritis.
Zhang K, Yu J, Li J, Fu W
The American journal of sports medicine 2024 Jan;52(1):140-154
The American journal of sports medicine 2024 Jan;52(1):140-154
Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway.
Liu Y, Zhou C, Tan J, Wu T, Pan C, Liu J, Cheng X
Chemical biology & drug design 2024 Jan;103(1):e14382
Chemical biology & drug design 2024 Jan;103(1):e14382
Exercise-induced modulation of myokine irisin on muscle-bone unit in the rat model of post-traumatic osteoarthritis.
Shang X, Hao X, Hou W, Liu J, Chi R, Deng X, Pan C, Xu T
Journal of orthopaedic surgery and research 2024 Jan 9;19(1):49
Journal of orthopaedic surgery and research 2024 Jan 9;19(1):49
Carveol alleviates osteoarthritis progression by acting on synovial macrophage polarization transformation: An in vitro and in vivo study.
Chen S, Xu H, He Y, Meng C, Fan Y, Qu Y, Wang Y, Zhou W, Huang X, You H
Chemico-biological interactions 2024 Jan 5;387:110781
Chemico-biological interactions 2024 Jan 5;387:110781
COL3A1 is a potential diagnostic biomarker for synovial chondromatosis and affects the cell cycle and migration of chondrocytes.
Chen WK, Zhang HJ, Liu J, Dai Z, Zhan XL
International immunopharmacology 2024 Jan 25;127:111416
International immunopharmacology 2024 Jan 25;127:111416
Calycosin ameliorates osteoarthritis by regulating the imbalance between chondrocyte synthesis and catabolism.
Su H, Yan Q, Du W, Hu E, Yang Z, Zhang W, Li Y, Tang T, Zhao S, Wang Y
BMC complementary medicine and therapies 2024 Jan 22;24(1):48
BMC complementary medicine and therapies 2024 Jan 22;24(1):48
The CREB1 inhibitor 666-15 maintains cartilage homeostasis and mitigates osteoarthritis progression.
Wang Y, Wu Z, Yan G, Li S, Zhang Y, Li G, Wu C
Bone & joint research 2024 Jan 2;13(1):4-18
Bone & joint research 2024 Jan 2;13(1):4-18
Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
Ma Z, Lu H, Feng X, Du T, Li J, Zhang Q, Gu X, Shao Y, Jing X, Su C
International journal of molecular medicine 2024 Feb;53(2)
International journal of molecular medicine 2024 Feb;53(2)
FOXO3-Activated HOTTIP Sequesters miR-615-3p away from COL2A1 to Mitigate Intervertebral Disc Degeneration.
Hao Y, Zhu G, Yu L, Ren Z, Zhou W, Zhang P, Lian X
The American journal of pathology 2024 Feb;194(2):280-295
The American journal of pathology 2024 Feb;194(2):280-295
Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6.
Wang X, Li X, Zhou J, Lei Z, Yang X
Chemico-biological interactions 2024 Feb 25;390:110890
Chemico-biological interactions 2024 Feb 25;390:110890
P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability.
Zheng Z, Shang X, Sun K, Hou Y, Zhang X, Xu J, Liu H, Ruan Z, Hou L, Guo Z, Wang G, Xu F, Guo F
Free radical biology & medicine 2024 Feb 20;212:336-348
Free radical biology & medicine 2024 Feb 20;212:336-348
SYNJ2BP ameliorates intervertebral disc degeneration by facilitating mitochondria-associated endoplasmic reticulum membrane formation and mitochondrial Zn(2+) homeostasis.
Song Y, Geng W, Zhu D, Liang H, Du Z, Tong B, Wang K, Li S, Gao Y, Feng X, Liao Z, Mei R, Yang C
Free radical biology & medicine 2024 Feb 20;212:220-233
Free radical biology & medicine 2024 Feb 20;212:220-233
Diatomite-incorporated hierarchical scaffolds for osteochondral regeneration.
Deng C, Qin C, Li Z, Lu L, Tong Y, Yuan J, Yin F, Cheng Y, Wu C
Bioactive materials 2024 Aug;38:305-320
Bioactive materials 2024 Aug;38:305-320
Degrasyn alleviates osteoarthritis by blocking macrophagic pyroptosis via suppressing NLRP3/GSDMD signaling pathway and protecting chondrocytes.
Xie S, Wang L, Lu C, Chen H, Ding Y, Jian X, Zhang Z, Zhu L
Cellular signalling 2024 Aug;120:111220
Cellular signalling 2024 Aug;120:111220
Injectable Microgels with Hybrid Exosomes of Chondrocyte-Targeted FGF18 Gene-Editing and Self-Renewable Lubrication for Osteoarthritis Therapy.
Chen M, Lu Y, Liu Y, Liu Q, Deng S, Liu Y, Cui X, Liang J, Zhang X, Fan Y, Wang Q
Advanced materials (Deerfield Beach, Fla.) 2024 Apr;36(16):e2312559
Advanced materials (Deerfield Beach, Fla.) 2024 Apr;36(16):e2312559
Injectable pathological microenvironment-responsive anti-inflammatory hydrogels for ameliorating intervertebral disc degeneration.
Liu L, Wang W, Huang L, Xian Y, Ma W, Fan J, Li Y, Liu H, Zheng Z, Wu D
Biomaterials 2024 Apr;306:122509
Biomaterials 2024 Apr;306:122509
Injectable silk fibroin peptide nanofiber hydrogel composite scaffolds for cartilage regeneration.
Wu D, Li J, Wang C, Su Z, Su H, Chen Y, Yu B
Materials today. Bio 2024 Apr;25:100962
Materials today. Bio 2024 Apr;25:100962
The NLRX1-SLC39A7 complex orchestrates mitochondrial dynamics and mitophagy to rejuvenate intervertebral disc by modulating mitochondrial Zn(2+) trafficking.
Song Y, Liang H, Li G, Ma L, Zhu D, Zhang W, Tong B, Li S, Gao Y, Wu X, Zhang Y, Feng X, Wang K, Yang C
Autophagy 2024 Apr;20(4):809-829
Autophagy 2024 Apr;20(4):809-829
Spermidine ameliorates osteoarthritis via altering macrophage polarization.
Ou Q, Tang S, Zhu J, Xue S, Huang H, Zhao Y, Cai Y, Wu C, Chen J, Ruan G, Ding C
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167083
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167083
Tenascin-C promotes endochondral ossification and fracture healing through Hedgehog and Hippo signaling.
Zhong F, Hao W, Chao H, Li Z, Chen S, Li S, Zhang S, Zhang K, Li Z, Liu H
Biochemical and biophysical research communications 2024 Apr 9;703:149634
Biochemical and biophysical research communications 2024 Apr 9;703:149634
CARMA3 Drives NF-κB Activation and Promotes Intervertebral Disc Degeneration: Involvement of CARMA3-BCL10-MALT1 Signalosome.
Liu Y, Zhang G, Wu J, Meng Y, Hu J, Fu H, Yang D
Inflammation 2024 Apr 12;
Inflammation 2024 Apr 12;
miR-1 Inhibits the Ferroptosis of Chondrocyte by Targeting CX43 and Alleviates Osteoarthritis Progression.
Zhou M, Zhai C, Shen K, Liu G, Liu L, He J, Chen J, Xu Y
Journal of immunology research 2023;2023:2061071
Journal of immunology research 2023;2023:2061071
Pioglitazone-Loaded Cartilage-Targeted Nanomicelles (Pio@C-HA-DOs) for Osteoarthritis Treatment.
Chen J, Xu W, Dai T, Jiao S, Xue X, Jiang J, Li S, Meng Q
International journal of nanomedicine 2023;18:5871-5890
International journal of nanomedicine 2023;18:5871-5890
The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies.
Li Y, Zhu S, Luo J, Tong Y, Zheng Y, Ji L, He Z, Jing Q, Huang J, Zhang Y, Bi Q
Drug design, development and therapy 2023;17:1515-1529
Drug design, development and therapy 2023;17:1515-1529
Therapeutic Effect of Acupotomy at Sanheyang for Cartilage Collagen Damage in Moderate Knee Osteoarthritis: A Rabbit Model.
Li Y, Hou Y, Sun J, Wei J, Chai Y, Guo M, Wang R
Journal of inflammation research 2023;16:2241-2254
Journal of inflammation research 2023;16:2241-2254
Digoxin protects against intervertebral disc degeneration via TNF/NF-κB and LRP4 signaling.
Meng Q, Liu K, Liu Z, Liu J, Tian Z, Qin S, Wei J, Cheng L
Frontiers in immunology 2023;14:1251517
Frontiers in immunology 2023;14:1251517
Microtubule stabilization promotes the synthesis of type 2 collagen in nucleus pulposus cell by activating hippo-yap pathway.
Zhang X, Shu S, Feng Z, Qiu Y, Bao H, Zhu Z
Frontiers in pharmacology 2023;14:1102318
Frontiers in pharmacology 2023;14:1102318
Overexpression of fibroblast growth factor receptor 2 in bone marrow mesenchymal stem cells enhances osteogenesis and promotes critical cranial bone defect regeneration.
Zhou Y, Zhu P, Shen S, Wang Y, Li B, Guo B, Li H
Frontiers in cell and developmental biology 2023;11:1208239
Frontiers in cell and developmental biology 2023;11:1208239
Quiescence preconditioned nucleus pulposus stem cells alleviate intervertebral disc degeneration by enhancing cell survival via adaptive metabolism pattern in rats.
Chen Q, Yang Q, Pan C, Ding R, Wu T, Cao J, Wu H, Zhao X, Li B, Cheng X
Frontiers in bioengineering and biotechnology 2023;11:1073238
Frontiers in bioengineering and biotechnology 2023;11:1073238
Identification of EGFR as an essential regulator in chondrocytes ferroptosis of osteoarthritis using bioinformatics, in vivo, and in vitro study.
Sun H, Peng G, Chen K, Xiong Z, Zhuang Y, Liu M, Ning X, Yang H, Deng J
Heliyon 2023 Sep;9(9):e19975
Heliyon 2023 Sep;9(9):e19975
Donor-Matched Peripheral Blood-Derived Mesenchymal Stem Cells Combined With Platelet-Rich Plasma Synergistically Ameliorate Surgery-Induced Osteoarthritis in Rabbits: An In Vitro and In Vivo Study.
Zhang K, Xu T, Xie H, Li J, Fu W
The American journal of sports medicine 2023 Sep;51(11):3008-3024
The American journal of sports medicine 2023 Sep;51(11):3008-3024
Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages.
Zhao X, Sun Z, Xu B, Duan W, Chang L, Lai K, Ye Z
Journal of nanobiotechnology 2023 Sep 4;21(1):317
Journal of nanobiotechnology 2023 Sep 4;21(1):317
Function and regulation of nuclear factor 1 X-type on chondrocyte proliferation and differentiation.
Pan D, Zhong J, Zhang J, Dong H, Zhao D, Zhang H, Yao B
Gene 2023 Sep 25;881:147620
Gene 2023 Sep 25;881:147620
Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis.
Zhao S, Xiu G, Wang J, Wen Y, Lu J, Wu B, Wang G, Yang D, Ling B, Du D, Xu J
Journal of nanobiotechnology 2023 Sep 22;21(1):341
Journal of nanobiotechnology 2023 Sep 22;21(1):341
TGF-β1 Triggers Salivary Hypofunction via Attenuating Protein Secretion and AQP5 Expression in Human Submandibular Gland Cells.
Chen Z, Chen X, Zhu B, Yu H, Bao X, Hou Y, Song W, Sun S, Li Z
Journal of proteome research 2023 Sep 1;22(9):2803-2813
Journal of proteome research 2023 Sep 1;22(9):2803-2813
Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF‑κB and MAPK signalling transduction through integrin αVβ3.
Wan J, Li M, Yuan X, Yu X, Chen A, Shao M, Kang H, Cheng P
International journal of molecular medicine 2023 Oct;52(4)
International journal of molecular medicine 2023 Oct;52(4)
An in vitro and in vivo study: Valencene protects cartilage and alleviates the progression of osteoarthritis by anti-oxidative stress and anti-inflammatory effects.
Chen S, Meng C, He Y, Xu H, Qu Y, Wang Y, Fan Y, Huang X, You H
International immunopharmacology 2023 Oct;123:110726
International immunopharmacology 2023 Oct;123:110726
Exploring the chondroprotective effect of Chaenomeles speciosa on Glucose-6-Phosphate Isomerase model mice using an integrated approach of network pharmacology and experimental validation.
Duan Z, Jin C, Deng Y, Liu J, Gu C, Wang J, Cai X, Li S, Zhou Y
Journal of ethnopharmacology 2023 Oct 5;314:116553
Journal of ethnopharmacology 2023 Oct 5;314:116553
Focused low-intensity pulsed ultrasound alleviates osteoarthritis via restoring impaired FUNDC1-mediated mitophagy.
Ye H, Li D, Wei X, Yu L, Jia L
iScience 2023 Oct 20;26(10):107772
iScience 2023 Oct 20;26(10):107772
Pentraxin 3 deficiency ameliorates the severity of osteoarthritis and alleviates inflammation.
Qiu C, Liu J, Li J, Di D, Li M, Liu T, Wang X, Zhao Y, Wang L, Liu X
Biochemical and biophysical research communications 2023 Oct 15;677:20-25
Biochemical and biophysical research communications 2023 Oct 15;677:20-25
Dapagliflozin suppress endoplasmic reticulum stress mediated apoptosis of chondrocytes by activating Sirt1.
Liu Z, Huang J, Wang X, Deng S, Zhou J, Gong Z, Li X, Wang Y, Yang J, Hu Y
Chemico-biological interactions 2023 Oct 1;384:110724
Chemico-biological interactions 2023 Oct 1;384:110724
α-Ketoglutaric acid ameliorates intervertebral disk degeneration by blocking the IL-6/JAK2/STAT3 pathway.
Xu HW, Fang XY, Liu XW, Zhang SB, Yi YY, Chang SJ, Chen H, Wang SJ
American journal of physiology. Cell physiology 2023 Oct 1;325(4):C1119-C1130
American journal of physiology. Cell physiology 2023 Oct 1;325(4):C1119-C1130
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death.
Chen X, Chen J, Miao C, Yin G, Zhang Z, Sun R, Ni S
Molecular medicine reports 2023 Nov;28(5)
Molecular medicine reports 2023 Nov;28(5)
Activation of the Nrf-2 pathway by pinocembrin safeguards vertebral endplate chondrocytes against apoptosis and degeneration caused by oxidative stress.
Wang H, Liu X, Yang H, Jing X, Wang W, Liu X, Zhang B, Liu X, Shao Y, Cui X
Life sciences 2023 Nov 15;333:122162
Life sciences 2023 Nov 15;333:122162
BSHXF-medicated serum combined with ADSCs regulates the TGF-β1/Smad pathway to repair oxidatively damaged NPCs and its component analysis.
Duan J, Li Z, Liu E, Long H, Chen L, Yang S
Journal of ethnopharmacology 2023 Nov 15;316:116692
Journal of ethnopharmacology 2023 Nov 15;316:116692
Sophisticated Magneto-Mechanical Actuation Promotes In Situ Stem Cell Assembly and Chondrogenesis for Treating Osteoarthritis.
Deng C, Li Z, Lu L, Zhang H, Chen R, Liu Y, Tong Y, Fan OR, Huang W, Sun YE, Yin F, Cheng Y
ACS nano 2023 Nov 14;17(21):21690-21707
ACS nano 2023 Nov 14;17(21):21690-21707
A20 ameliorates disc degeneration by suppressing mTOR/BNIP3 axis-mediated mitophagy.
Peng X, Zhang C, Gao JW, Wang F, Bao JP, Zhou ZM, Sun R, Ji HY, Vlf C, Wu XT
Genes & genomics 2023 May;45(5):657-671
Genes & genomics 2023 May;45(5):657-671
Integrin expression and extracellular matrix adhesion of septoclasts, pericytes, and endothelial cells at the chondro-osseous junction and the metaphysis of the proximal tibia in young mice.
Bando Y, Nagasaka A, Onozawa G, Sakiyama K, Owada Y, Amano O
Journal of anatomy 2023 May;242(5):831-845
Journal of anatomy 2023 May;242(5):831-845
The Bcr-Abl inhibitor DCC-2036 inhibits necroptosis and ameliorates osteoarthritis by targeting RIPK1 and RIPK3 kinases.
Piao L, Wu D, Rui C, Yang Y, Liu S, Liu J, Jin Z, Zhang H, Feng X, Bai L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114528
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114528
BuShen JianGu Fang alleviates cartilage degeneration via regulating multiple genes and signaling pathways to activate NF-κB/Sox9 axis.
Zhou Z, Lv C, Wang Y, Zhang B, Liu L, Yang J, Leng X, Zhao D, Yao B, Wang J, Dong H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154742
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154742
An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment.
Li G, Liu S, Chen Y, Zhao J, Xu H, Weng J, Yu F, Xiong A, Udduttula A, Wang D, Liu P, Chen Y, Zeng H
Nature communications 2023 May 31;14(1):3159
Nature communications 2023 May 31;14(1):3159
Polydopamine-Pd nanozymes as potent ROS scavengers in combination with near-infrared irradiation for osteoarthritis treatment.
Hu H, Yang J, Zhong Y, Wang J, Cai J, Luo C, Jin Z, Gao M, He M, Zheng L
iScience 2023 May 19;26(5):106605
iScience 2023 May 19;26(5):106605
Preparation of Melatonin-Loaded Nanoparticles with Targeting and Sustained Release Function and Their Application in Osteoarthritis.
Liang H, Yan Y, Sun W, Ma X, Su Z, Liu Z, Chen Y, Yu B
International journal of molecular sciences 2023 May 14;24(10)
International journal of molecular sciences 2023 May 14;24(10)
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
Lu R, Xu H, Deng X, Wang Y, He Z, Xu S, Liang S, Huang X, You H, Guo F, Cheng P, Chen AM
Journal of orthopaedic translation 2023 Mar;39:74-87
Journal of orthopaedic translation 2023 Mar;39:74-87
METTL3 promotes SMSCs chondrogenic differentiation by targeting the MMP3, MMP13, and GATA3.
Hu B, Zou X, Yu Y, Jiang Y, Xu H
Regenerative therapy 2023 Mar;22:148-159
Regenerative therapy 2023 Mar;22:148-159
An esterase-responsive ibuprofen nano-micelle pre-modified embryo derived nucleus pulposus progenitor cells promote the regeneration of intervertebral disc degeneration.
Xia KS, Li DD, Wang CG, Ying LW, Wang JK, Yang B, Shu JW, Huang XP, Zhang YA, Yu C, Zhou XP, Li FC, Slater NKH, Tang JB, Chen QX, Liang CZ
Bioactive materials 2023 Mar;21:69-85
Bioactive materials 2023 Mar;21:69-85
PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway.
Cui X, Liu X, Kong P, Du T, Li T, Yang G, Zhang W, Jing X, Wang W
Aging 2023 Mar 24;15(6):2275-2292
Aging 2023 Mar 24;15(6):2275-2292
Thermosensitive hydrogel for cartilage regeneration via synergistic delivery of SDF-1α like polypeptides and kartogenin.
Yuan X, Wan J, Yang Y, Huang L, Zhou C, Su J, Hua S, Pu H, Zou Y, Zhu H, Jiang X, Xiao J
Carbohydrate polymers 2023 Mar 15;304:120492
Carbohydrate polymers 2023 Mar 15;304:120492
Experimental study of miR-503 regulating the activity as well as the function of degenerated human nucleus pulposus cells of the intervertebral disc through inhibiting Wnt pathway.
Shi X, Tian S, Tian Y
Journal of musculoskeletal & neuronal interactions 2023 Mar 1;23(1):131-144
Journal of musculoskeletal & neuronal interactions 2023 Mar 1;23(1):131-144
A comprehensive analysis of single-cell RNA transcriptome reveals unique SPP1+ chondrocytes in human osteoarthritis.
Qu Y, Wang Y, Wang S, Yu X, He Y, Lu R, Chen S, Meng C, Xu H, Pei W, Ni B, Zhang R, Huang X, You H
Computers in biology and medicine 2023 Jun;160:106926
Computers in biology and medicine 2023 Jun;160:106926
Stevioside protects primary articular chondrocytes against IL-1β-induced inflammation and catabolism by targeting integrin.
Wan J, Zhu Z, He Z, Wu H, Chen A, Zhu W, Cheng P
International immunopharmacology 2023 Jun;119:110261
International immunopharmacology 2023 Jun;119:110261
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway.
Yang G, Liu X, Jing X, Wang J, Wang H, Chen F, Wang W, Shao Y, Cui X
International immunopharmacology 2023 Jun;119:110159
International immunopharmacology 2023 Jun;119:110159
tsRNA-04002 alleviates intervertebral disk degeneration by targeting PRKCA to inhibit apoptosis of nucleus pulposus cells.
Pan J, Liu Z, Shen B, Xu J, Dai G, Xu W, Wang J, Li L, Cheng L
Journal of orthopaedic surgery and research 2023 Jun 7;18(1):413
Journal of orthopaedic surgery and research 2023 Jun 7;18(1):413
Du Huo Ji Sheng Tang inhibits Notch1 signaling and subsequent NLRP3 activation to alleviate cartilage degradation in KOA mice.
Chen WJ, Zhuang Y, Peng W, Cui W, Zhang SJ, Wang JW
Chinese medicine 2023 Jun 29;18(1):80
Chinese medicine 2023 Jun 29;18(1):80
Wound Gel with Antimicrobial Effects Based on Polyvinyl Alcohol and Functional Aryloxycyclotriphosphazene.
Yudaev P, Butorova I, Chuev V, Posokhova V, Klyukin B, Chistyakov E
Polymers 2023 Jun 27;15(13)
Polymers 2023 Jun 27;15(13)
TNF-α activates RELA expression via TNFRSF1B to upregulate OPA1 expression and inhibit chondrogenic differentiation of human adipose stem cells.
Guo J, Ye W, Wu X, Huang H, Li B, Sun Z, Ren Z, Yang Z
Journal of orthopaedic surgery and research 2023 Jun 13;18(1):430
Journal of orthopaedic surgery and research 2023 Jun 13;18(1):430
EIF4A3-Induced Upregulation of hsa_circ_0040039 is a Biomarker and Aggravates IL-1β-Stimulated Intervertebral Disc Degeneration.
Li L, Cao Y, Deng H, Jia J, Fan X
Applied biochemistry and biotechnology 2023 Jul;195(7):4292-4307
Applied biochemistry and biotechnology 2023 Jul;195(7):4292-4307
Activating Mitochondrial Sirtuin 3 in Chondrocytes Alleviates Aging-Induced Fibrocartilage Layer Degeneration and Promotes Healing of Degenerative Rotator Cuff Injury.
Xie S, Guan C, Huang T, Yang G, Hu J, Sun D, Lu H
The American journal of pathology 2023 Jul;193(7):939-949
The American journal of pathology 2023 Jul;193(7):939-949
Exosomal miR-429 derived from adipose-derived stem cells ameliorated chondral injury in osteoarthritis via autophagy by targeting FEZ2.
Meng C, Na Y, Han C, Ren Y, Liu M, Ma P, Bai R
International immunopharmacology 2023 Jul;120:110315
International immunopharmacology 2023 Jul;120:110315
Targeting macrophagic PIM-1 alleviates osteoarthritis by inhibiting NLRP3 inflammasome activation via suppressing mitochondrial ROS/Cl(-) efflux signaling pathway.
Zhang Z, Xie S, Qian J, Gao F, Jin W, Wang L, Yan L, Chen H, Yao W, Li M, Wang X, Zhu L
Journal of translational medicine 2023 Jul 8;21(1):452
Journal of translational medicine 2023 Jul 8;21(1):452
Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy.
Bao J, Gao W, Zhang W, Wang D, Pan H
Journal of orthopaedic surgery and research 2023 Jul 6;18(1):485
Journal of orthopaedic surgery and research 2023 Jul 6;18(1):485
Pelargonidin ameliorates inflammatory response and cartilage degeneration in osteoarthritis via suppressing the NF-κB pathway.
Zeng Z, Li H, Luo C, Hu W, Weng TJ, Shuang F
Archives of biochemistry and biophysics 2023 Jul 15;743:109668
Archives of biochemistry and biophysics 2023 Jul 15;743:109668
Novel insights into the effect of deer IGF-1 on chondrocyte viability and IL-1β-induced inflammation response.
Zhong J, Zhang J, Zhou Z, Pan D, Zhao D, Dong H, Yao B
Journal of biochemical and molecular toxicology 2023 Jan;37(1):e23227
Journal of biochemical and molecular toxicology 2023 Jan;37(1):e23227
Activation of the kynurenine-aryl hydrocarbon receptor axis impairs the chondrogenic and chondroprotective effects of human umbilical cord-derived mesenchymal stromal cells in osteoarthritis rats.
Wang X, Zhao Y, Li S, Wang Y, Jia C, Yang X, Li S, Zhang B, Wei W, Chang Y
Human cell 2023 Jan;36(1):163-177
Human cell 2023 Jan;36(1):163-177
Increased FGFR3 is involved in T-2 toxin-induced lesions of hypertrophic cartilage associated with endemic osteoarthritis.
Zhang Y, Fang Q, Liu Y, Zhang D, He Y, Liu F, Sun K, Chen J
Human & experimental toxicology 2023 Jan-Dec;42:9603271231219480
Human & experimental toxicology 2023 Jan-Dec;42:9603271231219480
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.
Tian Y, Feng X, Zhou Z, Qin S, Chen S, Zhao J, Hou J, Liu D
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1499-1509
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1499-1509
Hypoxia-Inducible Factor-1α Protects Against Intervertebral Disc Degeneration Through Antagonizing Mitochondrial Oxidative Stress.
Yang W, Jia C, Liu L, Fu Y, Wu Y, Liu Z, Yu R, Ma X, Gong A, Liu F, Xia Y, Hou Y, Li Y, Zhang L
Inflammation 2023 Feb;46(1):270-284
Inflammation 2023 Feb;46(1):270-284
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Dai Z, Xia C, Zhao T, Wang H, Tian H, Xu O, Zhu X, Zhang J, Chen P
Materials today. Bio 2023 Feb;18:100512
Materials today. Bio 2023 Feb;18:100512
Indirubin protects chondrocytes and alleviates OA by inhibiting the MAPK and NF-κB pathways.
Wang X, Guo Z, Lin J, Sun K, Wang G, Hou L, Xu J, Guo J, Zhang X, Guo F, Wei Y
International immunopharmacology 2023 Feb;115:109624
International immunopharmacology 2023 Feb;115:109624
Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways.
Lu R, Wei Z, Wang Z, Xu S, Sun K, Cheng P, Huang X, You H, Guo F, Liang S, Chen AM
iScience 2023 Feb 17;26(2):105936
iScience 2023 Feb 17;26(2):105936
Astaxanthin Promotes the Survival of Adipose-Derived Stem Cells by Alleviating Oxidative Stress via Activating the Nrf2 Signaling Pathway.
Yang CS, Guo XS, Yue YY, Wang Y, Jin XL
International journal of molecular sciences 2023 Feb 14;24(4)
International journal of molecular sciences 2023 Feb 14;24(4)
Hypoxia dissociates HDAC6/FOXO1 complex and aggregates them into nucleus to regulate autophagy and osteogenic differentiation.
Xu Y, Wang Y, Xiao H, Li Y
Journal of periodontal research 2023 Dec;58(6):1248-1260
Journal of periodontal research 2023 Dec;58(6):1248-1260
Tranexamic Acid Causes Chondral Injury Through Chondrocytes Apoptosis Induced by Activating Endoplasmic Reticulum Stress.
Wang J, Liang S, Ma T, Chen S, Hu Y, Wang L
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 2023 Dec;39(12):2529-2546.e1
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 2023 Dec;39(12):2529-2546.e1
Enhancement and Repair of Degenerative Intervertebral Disc in Rats Using Platelet-Rich Plasma/Ferulic Acid Hydrogel.
Chai Q, Zhang B, Da Y, Wang W, Gao Y, Yao M, Zhu H, Yang X, Zhu Y
Cartilage 2023 Dec;14(4):506-515
Cartilage 2023 Dec;14(4):506-515
Cabozantinib prevents AGEs-induced degradation of type 2 collagen and aggrecan in human chondrocytes.
Dong Y, Lin L, Ji Y, Cheng X, Zhang Z
Aging 2023 Dec 6;15(23):13646-13654
Aging 2023 Dec 6;15(23):13646-13654
MiR-146b-5p enriched bioinspired exosomes derived from fucoidan-directed induction mesenchymal stem cells protect chondrocytes in osteoarthritis by targeting TRAF6.
Lou C, Jiang H, Lin Z, Xia T, Wang W, Lin C, Zhang Z, Fu H, Iqbal S, Liu H, Lin J, Wang J, Pan X, Xue X
Journal of nanobiotechnology 2023 Dec 18;21(1):486
Journal of nanobiotechnology 2023 Dec 18;21(1):486
Growth differentiation factor 5 inhibits lipopolysaccharide-mediated pyroptosis of nucleus pulposus mesenchymal stem cells via RhoA signaling pathway.
Zhu C, Zhou Q, Wang Z, Zhang J, Xu C, Ruan D
Molecular biology reports 2023 Aug;50(8):6337-6347
Molecular biology reports 2023 Aug;50(8):6337-6347
Ginsenoside compound K alleviates osteoarthritis by inhibiting NLRP3‑mediated pyroptosis.
Li Y, Wu J, Zhuo N
Experimental and therapeutic medicine 2023 Aug;26(2):406
Experimental and therapeutic medicine 2023 Aug;26(2):406
Exosomes derived from bone marrow mesenchymal stem cells pretreated with decellularized extracellular matrix enhance the alleviation of osteoarthritis through miR-3473b/phosphatase and tensin homolog axis.
Zhang Y, Qi G, Yan Y, Wang C, Wang Z, Jiang C, Jiang Z, Ma T, Zhang C, Yan Z
The journal of gene medicine 2023 Aug;25(8):e3510
The journal of gene medicine 2023 Aug;25(8):e3510
ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-κB signaling pathway.
Huang W, Tang H, Liu Y, Li W, Shimu AS, Li B, Zhu C
International immunopharmacology 2023 Aug;121:110433
International immunopharmacology 2023 Aug;121:110433
ADRM1/RPN13 attenuates cartilage extracellular matrix degradation via enhancing UCH37-mediated ALK5 deubiquitination.
Zhu M, Cao Z, Mo F, Shi S, Hu J, Xu Q, Quan K, Liang J, Li W, Hong X, Zhang B, Liu X, Dai M
International journal of biological macromolecules 2023 Aug 30;247:125670
International journal of biological macromolecules 2023 Aug 30;247:125670
Injectable photocrosslinking spherical hydrogel-encapsulated targeting peptide-modified engineered exosomes for osteoarthritis therapy.
Wan J, He Z, Peng R, Wu X, Zhu Z, Cui J, Hao X, Chen A, Zhang J, Cheng P
Journal of nanobiotechnology 2023 Aug 21;21(1):284
Journal of nanobiotechnology 2023 Aug 21;21(1):284
Kartogenin-loaded hydrogel promotes intervertebral disc repair via protecting MSCs against reactive oxygen species microenvironment by Nrf2/TXNIP/NLRP3 axis.
Wang F, Guo K, Nan L, Wang S, Lu J, Wang Q, Ba Z, Huang Y, Wu D
Free radical biology & medicine 2023 Aug 1;204:128-150
Free radical biology & medicine 2023 Aug 1;204:128-150
Piezo1-mediated mechanotransduction promotes entheseal pathological new bone formation in ankylosing spondylitis.
Chen S, Li Z, Chen D, Cui H, Wang J, Li Z, Li X, Zheng Z, Zhan Z, Liu H
Annals of the rheumatic diseases 2023 Apr;82(4):533-545
Annals of the rheumatic diseases 2023 Apr;82(4):533-545
Comparative transcriptome analysis provides insight into the molecular targets and signaling pathways of deer TGF-1 regulating chondrocytes proliferation and differentiation.
Zhou Z, Zhong J, Zhang J, Yang J, Leng X, Yao B, Wang X, Dong H
Molecular biology reports 2023 Apr;50(4):3155-3166
Molecular biology reports 2023 Apr;50(4):3155-3166
Withdrawn: X. Chen, Y. Li, M. Zhang, X. Wu, J. Zhu. Silencing LCK inactivates the NF-κB pathway to attenuate cartilage injury in osteoarthritis: An in vivo and in vitro study, published in The Journal of Gene Medicine.
The journal of gene medicine 2023 Apr;25(4):e3387
Lithium-Containing Biomaterials Stimulate Cartilage Repair through Bone Marrow Stromal Cells-Derived Exosomal miR-455-3p and Histone H3 Acetylation.
Liu L, Yu F, Chen L, Xia L, Wu C, Fang B
Advanced healthcare materials 2023 Apr;12(11):e2202390
Advanced healthcare materials 2023 Apr;12(11):e2202390
Integrated Cascade Nanozyme Remodels Chondrocyte Inflammatory Microenvironment in Temporomandibular Joint Osteoarthritis via Inhibiting ROS-NF-κB and MAPK Pathways.
Zhang Z, Yuan L, Liu Y, Wang R, Zhang Y, Yang Y, Wei H, Ma J
Advanced healthcare materials 2023 Apr;12(10):e2203195
Advanced healthcare materials 2023 Apr;12(10):e2203195
Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways.
Lu R, Wang YG, Qu Y, Wang SX, Peng C, You H, Zhu W, Chen A
Bone & joint research 2023 Apr 6;12(4):259-273
Bone & joint research 2023 Apr 6;12(4):259-273
Structural and biofunctional evaluation of decellularized jellyfish matrices.
Zhao J, Yu W, Zhang Q, Li X, Huang Y, Zhao S, Li T, Liu S, Li Y, Shan H
Journal of materials chemistry. B 2023 Apr 26;11(16):3740-3751
Journal of materials chemistry. B 2023 Apr 26;11(16):3740-3751
BRD4 Inhibition Suppresses Senescence and Apoptosis of Nucleus Pulposus Cells by Inducing Autophagy during Intervertebral Disc Degeneration: An In Vitro and In Vivo Study.
Zhang GZ, Chen HW, Deng YJ, Liu MQ, Wu ZL, Ma ZJ, He XG, Gao YC, Kang XW
Oxidative medicine and cellular longevity 2022;2022:9181412
Oxidative medicine and cellular longevity 2022;2022:9181412
Scrapie-Responsive Gene 1 Promotes Chondrogenic Differentiation of Umbilical Cord Mesenchymal Stem Cells via Wnt5a.
Zhou Y, Zheng T, Li L, Guo Y, Xiao J, Wang J, Du Z, Gao H, Tang W, Yang L, Hu H, Wang X, Meng M, Hou Z
Stem cells international 2022;2022:9124277
Stem cells international 2022;2022:9124277
DPSCs Protect Architectural Integrity and Alleviate Intervertebral Disc Degeneration by Regulating Nucleus Pulposus Immune Status.
Dong X, Hu F, Yi J, Zhang Y, Liu C, Geng P, Duan H, Wu CT, Zhang X, Wang H
Stem cells international 2022;2022:7590337
Stem cells international 2022;2022:7590337
Gastrocnemius Muscle Injury Is the Condition to Induce Cartilage Degeneration of the Rabbit Tibiofemoral Joint: A New Perspective.
Li Y, Sun J, Hou Y, Wei J, Chai Y, Zhu X, Wang R
BioMed research international 2022;2022:7532434
BioMed research international 2022;2022:7532434
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Chen J, Cui Z, Wang Y, Lyu L, Feng C, Feng D, Cheng Y, Li Z, Sun S
Oxidative medicine and cellular longevity 2022;2022:3182368
Oxidative medicine and cellular longevity 2022;2022:3182368
Zoledronate promotes ECM degradation and apoptosis via Wnt/β-catenin.
Xiao J, Li Y, Cheng G, Xu G
Open medicine (Warsaw, Poland) 2022;17(1):768-780
Open medicine (Warsaw, Poland) 2022;17(1):768-780
Corosolic Acid Protects Rat Chondrocytes Against IL-1β-Induced ECM Degradation by Activating Autophagy via PI3K/AKT/mTOR Pathway and Ameliorates Rat Osteoarthritis.
Han H, Chen M, Li Z, Zhou S, Wu Y, Wei J
Drug design, development and therapy 2022;16:2627-2637
Drug design, development and therapy 2022;16:2627-2637
3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy.
Tang H, Qin K, Wang A, Li S, Fang S, Gao W, Lu M, Huang W, Zhang H, Yin Z
Frontiers in pharmacology 2022;13:999851
Frontiers in pharmacology 2022;13:999851
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
Shao Y, Sun L, Yang G, Wang W, Liu X, Du T, Chen F, Jing X, Cui X
Frontiers in pharmacology 2022;13:937502
Frontiers in pharmacology 2022;13:937502
Innate/Inflammatory Bioregulation of Surfactant Protein D Alleviates Rat Osteoarthritis by Inhibiting Toll-Like Receptor 4 Signaling.
Jiang H, Zhang Y, Hu G, Shang X, Ming J, Deng M, Li Y, Ma Y, Liu S, Zhou Y
Frontiers in immunology 2022;13:913901
Frontiers in immunology 2022;13:913901
Saikosaponin D Inhibited IL-1β Induced ATDC 5 Chondrocytes Apoptosis In Vitro and Delayed Articular Cartilage Degeneration in OA Model Mice In Vivo.
Wu X, Zhao K, Fang X, Lu F, Cheng P, Song X, Zhang W, Yao C, Zhu J, Chen H
Frontiers in pharmacology 2022;13:845959
Frontiers in pharmacology 2022;13:845959
Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway.
Guo Z, Lin J, Sun K, Guo J, Yao X, Wang G, Hou L, Xu J, Guo J, Guo F
Frontiers in pharmacology 2022;13:791376
Frontiers in pharmacology 2022;13:791376
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Lu R, He Z, Zhang W, Wang Y, Cheng P, Lv Z, Yuan X, Guo F, You H, Chen AM, Hu W
Frontiers in endocrinology 2022;13:1060721
Frontiers in endocrinology 2022;13:1060721
Scutellarin Protects Against Mitochondrial Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation to Attenuate Intervertebral Disc Degeneration.
Wang Z, Zhang P, Zhao Y, Yu F, Wang S, Liu K, Cheng X, Shi J, He Q, Xia Y, Cheng L
Frontiers in bioengineering and biotechnology 2022;10:883118
Frontiers in bioengineering and biotechnology 2022;10:883118
Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes.
Wang W, Jing X, Du T, Ren J, Liu X, Chen F, Shao Y, Sun S, Yang G, Cui X
Free radical biology & medicine 2022 Sep;190:234-246
Free radical biology & medicine 2022 Sep;190:234-246
Omentin-1 promoted proliferation and ameliorated inflammation, apoptosis, and degeneration in human nucleus pulposus cells.
Cabral VLF, Wang F, Peng X, Gao J, Zhou Z, Sun R, Bao J, Wu X
Archives of gerontology and geriatrics 2022 Sep-Oct;102:104748
Archives of gerontology and geriatrics 2022 Sep-Oct;102:104748
Achyranthoside D (AD) improve intervertebral disc degeneration through affect the autophagy and the activation of PI3K/Akt/mTOR pathway.
Zhang C, Li Z, Li L, Li S, Yang L, Chen L, Zhang X, Yang S, Guo Y
Journal of orthopaedic surgery (Hong Kong) 2022 Sep-Dec;30(3):10225536221135474
Journal of orthopaedic surgery (Hong Kong) 2022 Sep-Dec;30(3):10225536221135474
Vasorin-containing small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system.
Liao Z, Ke W, Liu H, Tong B, Wang K, Feng X, Hua W, Wang B, Song Y, Luo R, Liang H, Zhang W, Zhao K, Li S, Yang C
Journal of nanobiotechnology 2022 Sep 19;20(1):420
Journal of nanobiotechnology 2022 Sep 19;20(1):420
Suramin enhances chondrogenic properties by regulating the p67(phox)/PI3K/AKT/SOX9 signalling pathway.
Liu ZM, Shen PC, Lu CC, Chou SH, Tien YC
Bone & joint research 2022 Oct;11(10):723-738
Bone & joint research 2022 Oct;11(10):723-738
Sinensetin attenuates IL-1β-induced cartilage damage and ameliorates osteoarthritis by regulating SERPINA3.
Liu Z, Liu R, Wang R, Dai J, Chen H, Wang J, Li X
Food & function 2022 Oct 3;13(19):9973-9987
Food & function 2022 Oct 3;13(19):9973-9987
Disrupted tenogenesis in masseter as a potential cause of micrognathia.
Liu C, Zhou N, Li N, Xu T, Chen X, Zhou H, Xie A, Liu H, Zhu L, Wang S, Xiao J
International journal of oral science 2022 Oct 18;14(1):50
International journal of oral science 2022 Oct 18;14(1):50
Implementation of Photosensitive, Injectable, Interpenetrating, and Kartogenin-Modified GELMA/PEDGA Biomimetic Scaffolds to Restore Cartilage Integrity in a Full-Thickness Osteochondral Defect Model.
Yu H, Feng M, Mao G, Li Q, Zhang Z, Bian W, Qiu Y
ACS biomaterials science & engineering 2022 Oct 10;8(10):4474-4485
ACS biomaterials science & engineering 2022 Oct 10;8(10):4474-4485
Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes.
Wang X, Liu Z, Peng P, Gong Z, Huang J, Peng H
Chemico-biological interactions 2022 Oct 1;366:110148
Chemico-biological interactions 2022 Oct 1;366:110148
Drugging the circadian clock feedback cycle to ameliorate cartilage degeneration.
He T, Pang S, Wang H, Yun H, Hao X, Jia L, Liu H, Wang D, Wang D, Xu H, Jie Q, Yang L, Zheng C
The FEBS journal 2022 Nov;289(21):6643-6658
The FEBS journal 2022 Nov;289(21):6643-6658
Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages.
Jin Y, Zhang Q, Qin X, Liu Z, Li Z, Zhong X, Xia L, He J, Fang B
Journal of nanobiotechnology 2022 Nov 3;20(1):469
Journal of nanobiotechnology 2022 Nov 3;20(1):469
BAG3 protects chondrocytes against lumbar facet joint osteoarthritis by regulating autophagy and apoptosis.
Lu X, Zhang J, Xue P, Wang Q, Wang X, Sun Y, Cui Z
Journal of physiology and biochemistry 2022 May;78(2):427-437
Journal of physiology and biochemistry 2022 May;78(2):427-437
Endoplasmin regulates differentiation of tonsil-derived mesenchymal stem cells into chondrocytes through ERK signaling.
Kim HR, Choi H, Park SY, Song YC, Kim JH, Shim S, Jun W, Kim KJ, Han J, Chi SW, Leem SH, Chung JW
BMB reports 2022 May;55(5):226-231
BMB reports 2022 May;55(5):226-231
Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis.
Zhang Y, Li S, Jin P, Shang T, Sun R, Lu L, Guo K, Liu J, Tong Y, Wang J, Liu S, Wang C, Kang Y, Zhu W, Wang Q, Zhang X, Yin F, Sun YE, Cui L
Nature communications 2022 May 4;13(1):2447
Nature communications 2022 May 4;13(1):2447
Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats.
Dai WY, Luo ZP
Cellular signalling 2022 Mar;91:110243
Cellular signalling 2022 Mar;91:110243
Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration.
Wang J, Xia D, Lin Y, Xu W, Wu Y, Chen J, Chu J, Shen P, Weng S, Wang X, Shen L, Fan S, Shen S
Experimental & molecular medicine 2022 Mar;54(3):285-297
Experimental & molecular medicine 2022 Mar;54(3):285-297
The anti-inflammation effect of strontium ranelate on rat chondrocytes with or without IL-1β in vitro.
Yu H, Liu Y, Yang X, He J, Zhong Q, Guo X
Experimental and therapeutic medicine 2022 Mar;23(3):208
Experimental and therapeutic medicine 2022 Mar;23(3):208
Mechanical loading mitigates osteoarthritis symptoms by regulating the inflammatory microenvironment in a mouse model.
Zheng W, Li X, Li J, Wang X, Liu D, Zhai L, Ding B, Li G, Sun Y, Yokota H, Zhang P
Annals of the New York Academy of Sciences 2022 Jun;1512(1):141-153
Annals of the New York Academy of Sciences 2022 Jun;1512(1):141-153
Isorhynchophylline ameliorates the progression of osteoarthritis by inhibiting the NF-κB pathway.
Li Z, Shi H, Li Y, Wang W, Li Z, Chen B, Nie D
European journal of pharmacology 2022 Jun 5;924:174971
European journal of pharmacology 2022 Jun 5;924:174971
Upregulation of P2Y12 inhibits chondrocyte apoptosis in lumbar osteoarthritis through the PI3K/AKT signaling pathway.
Wu G, Xue P, Jin H, Zhang M, Gui C, Bao G, Xu G, Jiang J, Zhang J, Cui S, Cui Z, Sun Y
Molecular biology reports 2022 Jul;49(7):6459-6466
Molecular biology reports 2022 Jul;49(7):6459-6466
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
Zhu W, Tang H, Cao L, Zhang J, Li J, Ma D, Guo C
Chemical biology & drug design 2022 Jul;100(1):108-120
Chemical biology & drug design 2022 Jul;100(1):108-120
MMP-10 Deficiency Effects Differentiation and Death of Chondrocytes Associated with Endochondral Osteogenesis in an Endemic Osteoarthritis.
Zhang D, Deng X, Liu Y, Zhang Y, Wang H, Zhang M, Fang Q, Yi C, Zhao X, Ma T, Wu C, Chen J
Cartilage 2022 Jul-Sep;13(3):19476035221109226
Cartilage 2022 Jul-Sep;13(3):19476035221109226
BMSC-derived exosomes promote tendon-bone healing after anterior cruciate ligament reconstruction by regulating M1/M2 macrophage polarization in rats.
Li Z, Li Q, Tong K, Zhu J, Wang H, Chen B, Chen L
Stem cell research & therapy 2022 Jul 15;13(1):295
Stem cell research & therapy 2022 Jul 15;13(1):295
Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1.
Jin Y, Liu Z, Li Z, Li H, Zhu C, Li R, Zhou T, Fang B
International journal of oral science 2022 Jul 14;14(1):34
International journal of oral science 2022 Jul 14;14(1):34
Folic Acid Inhibits Aging-Induced Telomere Attrition and Apoptosis in Astrocytes In Vivo and In Vitro.
Li Z, Zhou D, Zhang D, Zhao J, Li W, Sun Y, Chen Y, Liu H, Wilson JX, Qian Z, Huang G
Cerebral cortex (New York, N.Y. : 1991) 2022 Jan 10;32(2):286-297
Cerebral cortex (New York, N.Y. : 1991) 2022 Jan 10;32(2):286-297
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Wu ZL, Chen YJ, Zhang GZ, Xie QQ, Wang KP, Yang X, Liu TC, Wang ZQ, Zhao GH, Zhang HH
Apoptosis : an international journal on programmed cell death 2022 Feb;27(1-2):133-148
Apoptosis : an international journal on programmed cell death 2022 Feb;27(1-2):133-148
Chondroprotective effects of multiple PRP injections in osteoarthritis by apoptosis regulation and increased aggrecan synthesis- Immunohistochemistry based Guinea pig study.
Patel S, Mishra NP, Chouhan DK, Nahar U, Dhillon MS
Journal of clinical orthopaedics and trauma 2022 Feb;25:101762
Journal of clinical orthopaedics and trauma 2022 Feb;25:101762
A plant-derived natural photosynthetic system for improving cell anabolism.
Chen P, Liu X, Gu C, Zhong P, Song N, Li M, Dai Z, Fang X, Liu Z, Zhang J, Tang R, Fan S, Lin X
Nature 2022 Dec;612(7940):546-554
Nature 2022 Dec;612(7940):546-554
Exosome modification to better alleviates endoplasmic reticulum stress induced chondrocyte apoptosis and osteoarthritis.
Wang Y, Fan A, Lu L, Pan Z, Ma M, Luo S, Liu Z, Yang L, Cai J, Yin F
Biochemical pharmacology 2022 Dec;206:115343
Biochemical pharmacology 2022 Dec;206:115343
Freeze-casting osteochondral scaffolds: The presence of a nutrient-permeable film between the bone and cartilage defect reduces cartilage regeneration.
Chen J, Li Y, Liu S, Du Y, Zhang S, Wang J
Acta biomaterialia 2022 Dec;154:168-179
Acta biomaterialia 2022 Dec;154:168-179
Nodakenin attenuates cartilage degradation and inflammatory responses in a mice model of knee osteoarthritis by regulating mitochondrial Drp1/ROS/NLRP3 axis.
Yi N, Mi Y, Xu X, Li N, Chen B, Yan K, Tan K, Zhang B, Wang L, Kuang G, Lu M
International immunopharmacology 2022 Dec;113(Pt A):109349
International immunopharmacology 2022 Dec;113(Pt A):109349
Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway.
Ma T, Wang X, Qu W, Yang L, Jing C, Zhu B, Zhang Y, Xie W
Molecules (Basel, Switzerland) 2022 Dec 6;27(23)
Molecules (Basel, Switzerland) 2022 Dec 6;27(23)
An Injectable Hydrogel Scaffold Loaded with Dual-Drug/Sustained-Release PLGA Microspheres for the Regulation of Macrophage Polarization in the Treatment of Intervertebral Disc Degeneration.
Cheng H, Guo Q, Zhao H, Liu K, Kang H, Gao F, Guo J, Yuan X, Hu S, Li F, Yang Q, Fang Z
International journal of molecular sciences 2022 Dec 26;24(1)
International journal of molecular sciences 2022 Dec 26;24(1)
Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells.
Chen W, Yasen M, Wang H, Zhuang C, Wang Z, Lu S, Jiang L, Lin H
BMC pharmacology & toxicology 2022 Dec 1;23(1):90
BMC pharmacology & toxicology 2022 Dec 1;23(1):90
Knee Loading Enhances the Migration of Adipose-Derived Stem Cells to the Osteoarthritic Sites Through the SDF-1/CXCR4 Regulatory Axis.
Zhang Y, Li X, Li J, Liu D, Zhai L, Wang X, Abdurahman A, Yokota H, Zhang P
Calcified tissue international 2022 Aug;111(2):171-184
Calcified tissue international 2022 Aug;111(2):171-184
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Zhu W, Tang H, Li J, Guedes RM, Cao L, Guo C
Bioengineered 2022 Apr;13(4):9233-9247
Bioengineered 2022 Apr;13(4):9233-9247
Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis.
Yu H, Li M, Wen X, Yang J, Liang X, Li X, Bao X, Shu J, Ren X, Chen W, Li Z, Li Y
Arthritis research & therapy 2022 Apr 29;24(1):93
Arthritis research & therapy 2022 Apr 29;24(1):93
Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis.
Lin Z, Ni L, Teng C, Zhang Z, Wu L, Jin Y, Lu X, Lin Z
Frontiers in cell and developmental biology 2021;9:745621
Frontiers in cell and developmental biology 2021;9:745621
Reducing Inflammation and Vascular Invasion in Intervertebral Disc Degeneration via Cystathionine-γ-Lyase Inhibitory Effect on E-Selectin.
Xu H, Wei K, Tu J, Chen Y, He Y, Ding Y, Xu H, Bao X, Xie H, Fang H, Wang H
Frontiers in cell and developmental biology 2021;9:741046
Frontiers in cell and developmental biology 2021;9:741046
Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes.
Luo L, Gong J, Zhang H, Qin J, Li C, Zhang J, Tang Y, Zhang Y, Chen J, Zhou Y, Tian Z, Liu Y, Liu M
Frontiers in cell and developmental biology 2021;9:648201
Frontiers in cell and developmental biology 2021;9:648201
Exosomes Isolated From Bone Marrow Mesenchymal Stem Cells Exert a Protective Effect on Osteoarthritis via lncRNA LYRM4-AS1-GRPR-miR-6515-5p.
Wang X, Li Z, Cui Y, Cui X, Chen C, Wang Z
Frontiers in cell and developmental biology 2021;9:644380
Frontiers in cell and developmental biology 2021;9:644380
Single-Cell Profiles of Age-Related Osteoarthritis Uncover Underlying Heterogeneity Associated With Disease Progression.
Liu W, Chen Y, Zeng G, Yang S, Yang T, Ma M, Song W
Frontiers in molecular biosciences 2021;8:748360
Frontiers in molecular biosciences 2021;8:748360
Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.
Liao Z, Li S, Liu R, Feng X, Shi Y, Wang K, Li S, Zhang Y, Wu X, Yang C
Oxidative medicine and cellular longevity 2021;2021:5584447
Oxidative medicine and cellular longevity 2021;2021:5584447
MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis.
Ni B, Pei W, Qu Y, Zhang R, Chu X, Wang Y, Huang X, You H
Oxidative medicine and cellular longevity 2021;2021:4139048
Oxidative medicine and cellular longevity 2021;2021:4139048
Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3.
Jin Y, Li Z, Wu Y, Li H, Liu Z, Liu L, Ouyang N, Zhou T, Fang B, Xia L
Journal of inflammation research 2021;14:6067-6083
Journal of inflammation research 2021;14:6067-6083
Deletion of p16 accelerates fracture healing in geriatric mice.
Ding Q, Liu H, Liu L, Ma C, Qin H, Wei Y, Ren Y
American journal of translational research 2021;13(10):11107-11125
American journal of translational research 2021;13(10):11107-11125
Baicalein Alleviates Osteoarthritis Progression in Mice by Protecting Subchondral Bone and Suppressing Chondrocyte Apoptosis Based on Network Pharmacology.
Yi N, Mi Y, Xu X, Li N, Zeng F, Yan K, Tan K, Kuang G, Lu M
Frontiers in pharmacology 2021;12:788392
Frontiers in pharmacology 2021;12:788392
Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect.
Lu R, Yu X, Liang S, Cheng P, Wang Z, He ZY, Lv ZT, Wan J, Mo H, Zhu WT, Chen AM
Frontiers in pharmacology 2021;12:761922
Frontiers in pharmacology 2021;12:761922
Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development.
Zhou H, Li G, Wang Y, Jiang R, Li Y, Wang H, Wang F, Ma H, Cao L
Frontiers in pharmacology 2021;12:659597
Frontiers in pharmacology 2021;12:659597
Maresin-1 suppresses IL-1β-induced MMP-13 secretion by activating the PI3K/AKT pathway and inhibiting the NF-κB pathway in synovioblasts of an osteoarthritis rat model with treadmill exercise.
Lu J, Feng X, Zhang H, Wei Y, Yang Y, Tian Y, Bai L
Connective tissue research 2021 Sep;62(5):508-518
Connective tissue research 2021 Sep;62(5):508-518
Combination of graphene oxide and platelet-rich plasma improves tendon-bone healing in a rabbit model of supraspinatus tendon reconstruction.
Bao D, Sun J, Gong M, Shi J, Qin B, Deng K, Liu G, Zeng S, Xiang Z, Fu S
Regenerative biomaterials 2021 Oct;8(6):rbab045
Regenerative biomaterials 2021 Oct;8(6):rbab045
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro.
Gao XX, Liu CH, Hu ZL, Li HY, Chang X, Li YY, Zhang YY, Zhai Y, Li CQ
Frontiers in bioscience (Landmark edition) 2021 Oct 30;26(10):799-812
Frontiers in bioscience (Landmark edition) 2021 Oct 30;26(10):799-812
Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis.
Li S, Liu J, Liu S, Jiao W, Wang X
Journal of nanobiotechnology 2021 Oct 26;19(1):343
Journal of nanobiotechnology 2021 Oct 26;19(1):343
SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.
Ding N, Zeng MY, Song WJ, Xiao CX, Li EM, Wei B
Stem cells and development 2021 Oct 15;30(20):1028-1036
Stem cells and development 2021 Oct 15;30(20):1028-1036
Interleukin‑Iβ promotes cartilage degeneration by regulating forkhead box protein O4 and type Ⅱ collagen.
Wu J, Zhang H, Deng R, Xing L, Hu M, Fu X
Molecular medicine reports 2021 Nov;24(5)
Molecular medicine reports 2021 Nov;24(5)
LncRNA NONHSAT030515 promotes the chondrogenic differentiation of human adipose-derived stem cells via regulating the miR-490-5p/BMPR2 axis.
Yang Q, Guo J, Ren Z, Li B, Huang H, Yang Z
Journal of orthopaedic surgery and research 2021 Nov 6;16(1):658
Journal of orthopaedic surgery and research 2021 Nov 6;16(1):658
Hyaluronic acid hydrogel encapsulated BMP-14-modified ADSCs accelerate cartilage defect repair in rabbits.
Liu H, Rui Y, Liu J, Gao F, Jin Y
Journal of orthopaedic surgery and research 2021 Nov 3;16(1):657
Journal of orthopaedic surgery and research 2021 Nov 3;16(1):657
SNHG16/miR-485-5p/BMP7 axis modulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.
Asila A, Yang X, Kaisaer Y, Ma L
The journal of gene medicine 2021 Mar;23(3):e3296
The journal of gene medicine 2021 Mar;23(3):e3296
Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.
Huang H, Liu K, Ou H, Qian X, Wan J
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
Comparison of chondrogenesis-related biological behaviors between human urine-derived stem cells and human bone marrow mesenchymal stem cells from the same individual.
Sun J, Xing F, Zou M, Gong M, Li L, Xiang Z
Stem cell research & therapy 2021 Jun 28;12(1):366
Stem cell research & therapy 2021 Jun 28;12(1):366
Circular RNA circPDE4D Protects against Osteoarthritis by Binding to miR-103a-3p and Regulating FGF18.
Wu Y, Hong Z, Xu W, Chen J, Wang Q, Chen J, Ni W, Mei Z, Xie Z, Ma Y, Wang J, Lu J, Chen C, Fan S, Shen S
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Jan 6;29(1):308-323
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Jan 6;29(1):308-323
Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration.
Guo Z, Qiu C, Mecca C, Zhang Y, Bian J, Wang Y, Wu X, Wang T, Su W, Li X, Zhang W, Chen B, Xiang H
BMC musculoskeletal disorders 2021 Jan 13;22(1):77
BMC musculoskeletal disorders 2021 Jan 13;22(1):77
Silencing BLNK protects against interleukin-1β-induced chondrocyte injury through the NF-κB signaling pathway.
Cheng Y, Li F, Zhang WS, Zou GY, Shen YX
Cytokine 2021 Dec;148:155686
Cytokine 2021 Dec;148:155686
The characterization, cytotoxicity, macrophage response and tissue regeneration of decellularized cartilage in costal cartilage defects.
Changchen W, Hongquan W, Bo Z, Leilei X, Haiyue J, Bo P
Acta biomaterialia 2021 Dec;136:147-158
Acta biomaterialia 2021 Dec;136:147-158
Shockwave Treatment Enhanced Extracellular Matrix Production in Articular Chondrocytes Through Activation of the ROS/MAPK/Nrf2 Signaling Pathway.
Shen PC, Chou SH, Lu CC, Huang HT, Chien SH, Huang PJ, Liu ZM, Shih CL, Su SJ, Chen LM, Tien YC
Cartilage 2021 Dec;13(2_suppl):238S-253S
Cartilage 2021 Dec;13(2_suppl):238S-253S
LncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p/ADAMTS5 pathway.
Long H, Li Q, Xiao Z, Yang B
Bioengineered 2021 Dec;12(1):3148-3158
Bioengineered 2021 Dec;12(1):3148-3158
Role of the hippo signaling pathway in the extracellular matrix degradation of chondrocytes induced by fluoride exposure.
Yu FF, Zuo J, Fu X, Gao MH, Sun L, Yu SY, Li Z, Zhou GY, Ba Y
Ecotoxicology and environmental safety 2021 Dec 1;225:112796
Ecotoxicology and environmental safety 2021 Dec 1;225:112796
Sulforaphane protects against oxidative stress‑induced apoptosis via activating SIRT1 in mouse osteoarthritis.
Chen M, Huang L, Lv Y, Li L, Dong Q
Molecular medicine reports 2021 Aug;24(2)
Molecular medicine reports 2021 Aug;24(2)
ZIP8 mediates the extracellular matrix degradation of nucleus pulposus cells via NF-κB signaling pathway.
Ding W, Ge Y, Sun H, Xu J, Gu H, Bian C, Chen H, Jiang L, Yin X
Biochemical and biophysical research communications 2021 Apr 23;550:30-36
Biochemical and biophysical research communications 2021 Apr 23;550:30-36
Simultaneous Recruitment of Stem Cells and Chondrocytes Induced by a Functionalized Self-Assembling Peptide Hydrogel Improves Endogenous Cartilage Regeneration.
Lv X, Sun C, Hu B, Chen S, Wang Z, Wu Q, Fu K, Xia Z, Shao Z, Wang B
Frontiers in cell and developmental biology 2020;8:864
Frontiers in cell and developmental biology 2020;8:864
OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.
Tian J, Cheng C, Kuang SD, Su C, Zhao X, Xiong YL, Li YS, Gao SG
Pain research & management 2020;2020:3428587
Pain research & management 2020;2020:3428587
Steady Augmentation of Anti-Osteoarthritic Actions of Rapamycin by Liposome-Encapsulation in Collaboration with Low-Intensity Pulsed Ultrasound.
Chen CH, Kuo SM, Tien YC, Shen PC, Kuo YW, Huang HH
International journal of nanomedicine 2020;15:3771-3790
International journal of nanomedicine 2020;15:3771-3790
Matrisome Provides a Supportive Microenvironment for Skin Functions of Diverse Species.
Liu B, Zhang S, Wang W, Yun Z, Lv L, Chai M, Wu Z, Zhu Y, Ma J, Leng L
ACS biomaterials science & engineering 2020 Oct 12;6(10):5720-5733
ACS biomaterials science & engineering 2020 Oct 12;6(10):5720-5733
MSCs reduce airway remodeling in the lungs of asthmatic rats through the Wnt/β-catenin signaling pathway.
Song J, Zhu XM, Wei QY
European review for medical and pharmacological sciences 2020 Nov;24(21):11199-11211
European review for medical and pharmacological sciences 2020 Nov;24(21):11199-11211
Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression.
Zhang X, Huang CR, Pan S, Pang Y, Chen YS, Zha GC, Guo KJ, Zheng X
International immunopharmacology 2020 Jun;83:106425
International immunopharmacology 2020 Jun;83:106425
MicroRNA-675-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GNG5.
Shen XF, Cheng Y, Dong QR, Zheng MQ
Biochemical and biophysical research communications 2020 Jun 25;527(2):458-465
Biochemical and biophysical research communications 2020 Jun 25;527(2):458-465
Sialic acid-modified chitosan oligosaccharide-based biphasic calcium phosphate promote synergetic bone formation in rheumatoid arthritis therapy.
Xu XL, Shu GF, Wang XJ, Qi J, Jin FY, Shen QY, Ying XY, Ji JS, Du YZ
Journal of controlled release : official journal of the Controlled Release Society 2020 Jul 10;323:578-590
Journal of controlled release : official journal of the Controlled Release Society 2020 Jul 10;323:578-590
L-polylactic acid porous microspheres enhance the mechanical properties and in vivo stability of degummed silk/silk fibroin/gelatin scaffold.
Li T, Liu B, Jiang Y, Lou Y, Chen K, Zhang D
Biomedical materials (Bristol, England) 2020 Dec 17;16(1):015025
Biomedical materials (Bristol, England) 2020 Dec 17;16(1):015025
Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice.
Wang W, Yang R, Zhang M, Li J, Peng J, Xu M, Zhao Y, Li H, Pan X
Inflammation 2020 Aug;43(4):1312-1322
Inflammation 2020 Aug;43(4):1312-1322
p-Coumaric Acid Attenuates IL-1β-Induced Inflammatory Responses and Cellular Senescence in Rat Chondrocytes.
Huang X, You Y, Xi Y, Ni B, Chu X, Zhang R, You H
Inflammation 2020 Apr;43(2):619-628
Inflammation 2020 Apr;43(2):619-628
Overexpression of miR-10a-5p facilitates the progression of osteoarthritis.
Li HZ, Xu XH, Lin N, Wang DW, Lin YM, Su ZZ, Lu HD
Aging 2020 Apr 13;12(7):5948-5976
Aging 2020 Apr 13;12(7):5948-5976
MicroRNA-132 upregulation promotes matrix degradation in intervertebral disc degeneration.
Liu W, Xia P, Feng J, Kang L, Huang M, Wang K, Song Y, Li S, Wu X, Yang S, Yang C
Experimental cell research 2017 Oct 1;359(1):39-49
Experimental cell research 2017 Oct 1;359(1):39-49
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Tu J, Li W, Zhang Y, Wu X, Song Y, Kang L, Liu W, Wang K, Li S, Hua W, Yang C
Inflammation 2017 Jun;40(3):725-734
Inflammation 2017 Jun;40(3):725-734
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