15943-1-AP

antibody from Proteintech Group

Targeting: COL2A1 AOM, SEDC, STL1

Provider product page for 15943-1-AP

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [59]
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Validations
Western blot [1]

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Product number: 15943-1-AP - Provider product page
Provider: Proteintech Group
Product name: Collagen Type II antibody
Antibody type: Polyclonal
Description: Collagen Type II antibody (Cat. #15943-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

COL2A1 protein structure - 15943-1-AP shown in red.

Submitted references microRNA-365 attenuated intervertebral disc degeneration through modulating nucleus pulposus cell apoptosis and extracellular matrix degradation by targeting EFNA3.

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DMT1-mediated iron overload accelerates cartilage degeneration in Hemophilic Arthropathy through the mtDNA-cGAS-STING axis.

Liu H, Chi R, Xu J, Guo J, Guo Z, Zhang X, Hou L, Zheng Z, Lu F, Xu T, Sun K, Guo F
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167058

Tizoxanide as a novel theraputic candidate for osteoarthritis.

Ni B, Yan J, Cai W, Xiao Y, Tu C
Heliyon 2023 Sep;9(9):e19472

Mitoquinone alleviates osteoarthritis progress by activating the NRF2-Parkin axis.

Hou L, Wang G, Zhang X, Lu F, Xu J, Guo Z, Lin J, Zheng Z, Liu H, Hou Y, Sun K, Guo F
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JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy.

Sun K, Hou L, Guo Z, Wang G, Guo J, Xu J, Zhang X, Guo F
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Inhibition of TRADD ameliorates chondrocyte necroptosis and osteoarthritis by blocking RIPK1-TAK1 pathway and restoring autophagy.

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BMP7 ameliorates intervertebral disc degeneration in type 1 diabetic rats by inhibiting pyroptosis of nucleus pulposus cells and NLRP3 inflammasome activity.

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Desferoxamine protects against hemophilic arthropathy through the upregulation of HIF-1α-BNIP3 mediated mitophagy.

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Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying circ_0050205 Attenuate Intervertebral Disc Degeneration.

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ALPK1 Accelerates the Pathogenesis of Osteoarthritis by Activating NLRP3 Signaling.

Liu X, Zhao J, Jiang H, Guo H, Li Y, Li H, Feng Y, Ke J, Long X
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Oct;37(10):1973-1985

ALPK1 Aggravates TMJOA Cartilage Degradation via NF-κB and ERK1/2 Signaling.

Liu X, Zhao J, Jiang H, Li H, Feng Y, Ke J, Long X
Journal of dental research 2022 Nov;101(12):1499-1509

PRDX2 Knockdown Inhibits Extracellular Matrix Synthesis of Chondrocytes by Inhibiting Wnt5a/YAP1/CTGF and Activating IL-6/JAK2/STAT3 Pathways in Deer Antler.

Sun X, Gu X, Peng J, Yang L, Zhang X, Ran Z, Xiong J
International journal of molecular sciences 2022 May 7;23(9)

The anti-inflammation effect of strontium ranelate on rat chondrocytes with or without IL-1β in vitro.

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Experimental and therapeutic medicine 2022 Mar;23(3):208

Melatonin Promotes Antler Growth by Accelerating MT1-Mediated Mesenchymal Cell Differentiation and Inhibiting VEGF-Induced Degeneration of Chondrocytes.

Sun X, Gu X, Li K, Li M, Peng J, Zhang X, Yang L, Xiong J
International journal of molecular sciences 2022 Jan 11;23(2)

C/EBP-β contributes to pig endometrial LE receptivity by targeting cell remodeling genes during implantation.

Sun Y, Yang Y, Jiang Z, Wang F, Han K, Hong L, Cao J, Yu M
Reproduction (Cambridge, England) 2022 Dec 1;164(6):269-281

Synovial mesenchymal stem cell-derived extracellular vesicles alleviate chondrocyte damage during osteoarthritis through microRNA-130b-3p-mediated inhibition of the LRP12/AKT/β-catenin axis.

Zeng Z, Dai Y, Deng S, Zou S, Dou T, Wei F
Immunopharmacology and immunotoxicology 2022 Apr;44(2):247-260

Selonsertib Alleviates the Progression of Rat Osteoarthritis: An in vitro and in vivo Study.

Yan J, Zhang Y, Sheng G, Ni B, Xiao Y, Wang S, Wang T, Ma Y, Wang H, Wu H, Tu C
Frontiers in pharmacology 2021;12:687033

M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Rα2/MAPK Pathway in Rat Intervertebral Disc Degeneration.

Li L, Wei K, Ding Y, Ahati P, Xu H, Fang H, Wang H
Frontiers in immunology 2021;12:666361

Rhoifolin Ameliorates Osteoarthritis via Regulating Autophagy.

Yan J, Ni B, Sheng G, Zhang Y, Xiao Y, Ma Y, Li H, Wu H, Tu C
Frontiers in pharmacology 2021;12:661072

Human Bone Mesenchymal Stem Cell-Derived Exosomes Inhibit IL-1β-Induced Inflammation in Osteoarthritis Chondrocytes.

Zhou L, Ye H, Liu L, Chen Y
Cell journal 2021 Sep;23(4):485-494

Chondroprotective and antiarthritic effects of galangin in osteoarthritis: An in vitro and in vivo study.

Huang X, Pei W, Ni B, Zhang R, You H
European journal of pharmacology 2021 Sep 5;906:174232

HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy.

He R, Wang Z, Cui M, Liu S, Wu W, Chen M, Wu Y, Qu Y, Lin H, Chen S, Wang B, Shao Z
Autophagy 2021 Nov;17(11):3338-3360

Zonal-Layered Chondrocyte Sheets for Repairment of Full-Thickness Articular Cartilage Defect: A Mini-Pig Model.

Shen PC, Lu CC, Chou SH, Liu ZM, Su SJ, Tien YC
Biomedicines 2021 Nov 30;9(12)

Growth factors contribute to the mediation of angiogenic capacity of glioma-associated mesenchymal stem cells.

Zhang Q, Xiang W, Xue BZ, Yi DY, Zhao HY, Fu P
Oncology letters 2021 Mar;21(3):215

Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study.

Sun K, Luo J, Jing X, Xiang W, Guo J, Yao X, Liang S, Guo F, Xu T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153387

ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.

Ding J, Zhang R, Li H, Ji Q, Cheng X, Thorne RF, Hondermarck H, Liu X, Shen C
Aging 2021 Apr 6;13(7):10703-10723

Oxymatrine Liposomes for Intervertebral Disc Treatment: Formulation, in vitro and vivo Assessments.

Wang H, Ding Y, Zhang W, Wei K, Pei Y, Zou C, Zhang C, Ding J, Fang H, Tan S
Drug design, development and therapy 2020;14:921-931

Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.

Wei K, Dai J, Wang Z, Pei Y, Chen Y, Ding Y, Ding Q, Ahati P, Zhou X, Wang H, Fang H
Experimental biology and medicine (Maywood, N.J.) 2020 Mar;245(6):532-541

lncRNA HOTAIR upregulates autophagy to promote apoptosis and senescence of nucleus pulposus cells.

Zhan S, Wang K, Xiang Q, Song Y, Li S, Liang H, Luo R, Wang B, Liao Z, Zhang Y, Yang C
Journal of cellular physiology 2020 Mar;235(3):2195-2208

Genipin-crosslinked decellularized annulus fibrosus hydrogels induces tissue-specific differentiation of bone mesenchymal stem cells and intervertebral disc regeneration.

Peng Y, Huang D, Li J, Liu S, Qing X, Shao Z
Journal of tissue engineering and regenerative medicine 2020 Mar;14(3):497-509

A comprehensive analysis on the effects of 1,25(OH)2D3 on primary chondrocytes cultured from patients with osteoarthritis.

Zhang G, Gu M, Xu Y, Wu Z
Gene 2020 Mar 10;730:144322

The GPR55 antagonist CID16020046 mitigates advanced glycation end products (AGEs)- induced chondrocyte activation.

Zeng Y, Liu Z, Tan X, Lei L
Chemico-biological interactions 2020 Jul 1;325:109088

Protectin DX attenuates IL-1β-induced inflammation via the AMPK/NF-κB pathway in chondrocytes and ameliorates osteoarthritis progression in a rat model.

Piao S, Du W, Wei Y, Yang Y, Feng X, Bai L
International immunopharmacology 2020 Jan;78:106043

Advanced oxidation protein products increase TNF-α and IL-1β expression in chondrocytes via NADPH oxidase 4 and accelerate cartilage degeneration in osteoarthritis progression.

Liao CR, Wang SN, Zhu SY, Wang YQ, Li ZZ, Liu ZY, Jiang WS, Chen JT, Wu Q
Redox biology 2020 Jan;28:101306

High BMPR2 expression leads to enhanced SMAD1/5/8 signalling and GDF6 responsiveness in human adipose-derived stem cells: implications for stem cell therapies for intervertebral disc degeneration.

Hodgkinson T, Wignall F, Hoyland JA, Richardson SM
Journal of tissue engineering 2020 Jan-Dec;11:2041731420919334

Vitamin D3 protects articular cartilage by inhibiting the Wnt/β-catenin signaling pathway.

Yang T, Sun W, Duan YH, Sun YB, Ren YM, Hou WY, Tian MQ
Experimental and therapeutic medicine 2020 Aug;20(2):1775-1781

TRIM59 attenuates IL-1β-driven cartilage matrix degradation in osteoarthritis via direct suppression of NF-κB and JAK2/STAT3 signaling pathway.

Teng Y, Ni G, Zhang W, Hua J, Sun L, Zheng M, Dong Q, Huang W
Biochemical and biophysical research communications 2020 Aug 13;529(1):28-34

Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane.

Xu X, Wang D, Zheng C, Gao B, Fan J, Cheng P, Liu B, Yang L, Luo Z
Theranostics 2019;9(8):2252-2267

KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.

Gao X, Jiang S, Du Z, Ke A, Liang Q, Li X
Oxidative medicine and cellular longevity 2019;2019:8564681

Schisandrin A Inhibits the IL-1β-Induced Inflammation and Cartilage Degradation via Suppression of MAPK and NF-κB Signal Pathways in Rat Chondrocytes.

Tu C, Huang X, Xiao Y, Song M, Ma Y, Yan J, You H, Wu H
Frontiers in pharmacology 2019;10:41

Liquiritigenin inhibits IL-1β-induced inflammation and cartilage matrix degradation in rat chondrocytes.

Tu C, Ma Y, Song M, Yan J, Xiao Y, Wu H
European journal of pharmacology 2019 Sep 5;858:172445

Vanillic acid attenuates cartilage degeneration by regulating the MAPK and PI3K/AKT/NF-κB pathways.

Huang X, Xi Y, Mao Z, Chu X, Zhang R, Ma X, Ni B, Cheng H, You H
European journal of pharmacology 2019 Sep 15;859:172481

Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis.

Sun K, Luo J, Jing X, Guo J, Yao X, Hao X, Ye Y, Liang S, Lin J, Wang G, Guo F
Aging 2019 Nov 26;11(22):10513-10531

A cancellous bone matrix system with specific mineralisation degrees for mesenchymal stem cell differentiation and bone regeneration.

Liu S, Wang Y, Wang J, Qiu P, Wang S, Shi Y, Li M, Chen P, Lin X, Fang X
Biomaterials science 2019 May 28;7(6):2452-2467

miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis.

Wu J, Kuang L, Chen C, Yang J, Zeng WN, Li T, Chen H, Huang S, Fu Z, Li J, Liu R, Ni Z, Chen L, Yang L
Biomaterials 2019 Jun;206:87-100

miR-93-5p attenuates IL-1β-induced chondrocyte apoptosis and cartilage degradation in osteoarthritis partially by targeting TCF4.

Xue H, Tu Y, Ma T, Wen T, Yang T, Xue L, Cai M, Wang F, Guan M
Bone 2019 Jun;123:129-136

Role of synovium-derived fibrous cartilage in temporomandibular joint synovial chondromatosis.

Li Y, Feng Y, Cao P, Ke J, Fang W, Cai H, Deng M, Long X
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2019 Jan;48(1):79-86

Isorhapontigenin Suppresses Interleukin-1β-Induced Inflammation and Cartilage Matrix Damage in Rat Chondrocytes.

Ma Y, Tu C, Liu W, Xiao Y, Wu H
Inflammation 2019 Dec;42(6):2278-2285

Protective effects of ten oligostilbenes from Paeonia suffruticosa seeds on interleukin-1β-induced rabbit osteoarthritis chondrocytes.

He YK, Cen XT, Liu SS, Lu HD, He CN
BMC chemistry 2019 Dec;13(1):72

Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis.

Huang X, Ni B, Xi Y, Chu X, Zhang R, You H
Aging 2019 Dec 16;11(24):12532-12545

SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis.

Wang J, Wang K, Huang C, Lin D, Zhou Y, Wu Y, Tian N, Fan P, Pan X, Xu D, Hu J, Zhou Y, Wang X, Zhang X
International journal of biological sciences 2018;14(13):1873-1882

Development of chondrocyte-seeded electrosprayed nanoparticles for repair of articular cartilage defects in rabbits.

Yang SW, Ku KC, Chen SY, Kuo SM, Chen IF, Wang TY, Chang SJ
Journal of biomaterials applications 2018 Jan;32(6):800-812

Taurine alleviates endoplasmic reticulum stress in the chondrocytes from patients with osteoarthritis.

Bian Y, Wang H, Sun S
Redox report : communications in free radical research 2018 Dec;23(1):118-124

Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo.

Ding QH, Ye CY, Chen EM, Zhang W, Wang XH
International immunopharmacology 2018 Aug;61:222-230

Lin28a overexpression reveals the role of Erk signaling in articular cartilage development.

Kobayashi T, Kozlova A
Development (Cambridge, England) 2018 Aug 2;145(15)

T140 blocks the SDF-1/CXCR4 signaling pathway and prevents cartilage degeneration in an osteoarthritis disease model.

Wang K, Li Y, Han R, Cai G, He C, Wang G, Jia D
PloS one 2017;12(4):e0176048

Heme oxygenase-1 attenuates IL-1β induced alteration of anabolic and catabolic activities in intervertebral disc degeneration.

Hu B, Shi C, Xu C, Cao P, Tian Y, Zhang Y, Deng L, Chen H, Yuan W
Scientific reports 2016 Feb 15;6:21190

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Collagen Type II antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human Collagen Type II. This antibody recognizes human antigen. The Collagen Type II antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 15943-1-AP.pdf

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