Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Immunohistochemistry [1]
- Other assay [1]
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Validation data
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- Product number
- NBP2-75758-20ug - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal CDX2 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified. The specificity of this monoclonal antibody to its intended target was validated by HuProt Human Proteome Microarray, containing more than 19,000, full-length human proteins. The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoids and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma. However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 20 ug
- Concentration
- 0.2 mg/ml
- Storage
- Store at 4C.
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: CDX2 Antibody (UPK1A/2923) [NBP2-75758] - Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with CDX2 Mouse Monoclonal Antibody (PCRP-CDX2-1A3).
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Microarray: CDX2 Antibody (UPK1A/2923) [NBP2-75758] - Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29. Image using the Azide and BSA Free format of this antibody.