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- Antibody Data
- Antigen structure
- References [20]
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- Product number
- 24601-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- Tuberin antibody
- Antibody type
- Polyclonal
- Description
- Tuberin antibody (Cat. #24601-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse , rat and has been validated for the following applications: IF, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The effect of 4.3 GHz high-power microwave exposure on human corneal epithelial cells.
Integrating multi-omics approaches to elucidate the mechanism of XiaoPi Decoction in treating hyperplasia of mammary glands via AMPK signaling pathway activation.
The critical role of the proto-oncogene c-Kit in TSC renal cystogenesis.
Targeting TTK Inhibits Tumorigenesis of T-Cell Lymphoma Through Dephosphorylating p38α and Activating AMPK/mTOR Pathway.
YTHDF1 differentiates the contributing roles of mTORC1 in aging.
The Activation of the Microglial NLRP3 Inflammasome Is Involved in Tuberous Sclerosis Complex-Related Neuroinflammation.
Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration.
HCMV immediate-early protein IE2 induces neurotoxicity and hearing loss by disrupting TSC2-mTOR signaling and metabolic homeostasis.
Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity.
The FTO Mediated N6-Methyladenosine Modification of DDIT4 Regulation with Tumorigenesis and Metastasis in Prostate Cancer.
mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis.
25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages.
Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma.
MLN4924 Suppresses head and neck squamous cell carcinoma progression by inactivating the mTOR signaling pathway via the NEDD8/CUL4/TSC2 axis.
miR-25-5p in exosomes derived from UVB-induced fibroblasts regulates melanogenesis via TSC2-dominated cellular organelle dysfunction.
Resistance to anti-HER2 therapy associated with the TSC2 nonsynonymous variant c.4349 C > G (p.Pro1450Arg) is reversed by CDK4/6 inhibitor in HER2-positive breast cancer.
Inhibition of autophagy and induction of glioblastoma cell death by NEO214, a perillyl alcohol-rolipram conjugate.
A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression.
Oleanolic Acid Induces Autophagy and Apoptosis via the AMPK-mTOR Signaling Pathway in Colon Cancer.
Effect of STAT3 mediated epigenetic regulation in pre-eclampsia: an analysis of trial data.
Gao A, Zhao X, Wu S, Liu X, Wang X, Tan L, Li Z, Dong G, Wang C
Frontiers in cell and developmental biology 2026;14:1729198
Frontiers in cell and developmental biology 2026;14:1729198
Integrating multi-omics approaches to elucidate the mechanism of XiaoPi Decoction in treating hyperplasia of mammary glands via AMPK signaling pathway activation.
Chen L, Hu M, Ding XQ, Chen YG, Zeng QY, Zhang Z, Wang X, Liu HT
Journal of ethnopharmacology 2026 Mar 25;359:121060
Journal of ethnopharmacology 2026 Mar 25;359:121060
The critical role of the proto-oncogene c-Kit in TSC renal cystogenesis.
Zahedi K, Barone S, Brooks M, Zhang W, Yu JJ, Zaidman NA, Soleimani M
EMBO molecular medicine 2026 Feb;18(2):575-598
EMBO molecular medicine 2026 Feb;18(2):575-598
Targeting TTK Inhibits Tumorigenesis of T-Cell Lymphoma Through Dephosphorylating p38α and Activating AMPK/mTOR Pathway.
Liu B, Lu T, Ding M, Zhou X, Jiang Y, Shang J, Sun W, Hu S, Wang X, Zhou X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(10):e2413990
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(10):e2413990
YTHDF1 differentiates the contributing roles of mTORC1 in aging.
Xu C, Yu C, Zhang J, Zhang Z, Zhang J, Meng Y, Wang M, Wen M, Chen J, Ning Y, Chen X, Gu J, Su W, Liu B
Molecular cell 2025 Jun 5;85(11):2194-2210.e8
Molecular cell 2025 Jun 5;85(11):2194-2210.e8
The Activation of the Microglial NLRP3 Inflammasome Is Involved in Tuberous Sclerosis Complex-Related Neuroinflammation.
Ding R, Zhang S, Meng L, Wang L, Han Z, Gui J, Yang J, Cheng L, Xie L, Jiang L
International journal of molecular sciences 2025 Jul 26;26(15)
International journal of molecular sciences 2025 Jul 26;26(15)
Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration.
Chen H, Liu C, Cui S, Xia Y, Zhang K, Cheng H, Peng J, Yu X, Li L, Yu H, Zhang J, Zheng JS, Zhang B
Cell 2025 Jan 9;188(1):157-174.e22
Cell 2025 Jan 9;188(1):157-174.e22
HCMV immediate-early protein IE2 induces neurotoxicity and hearing loss by disrupting TSC2-mTOR signaling and metabolic homeostasis.
Yu M, Wang Z, Wang Y, Zhang X, Wei Z, Wang B
Journal of neuroinflammation 2025 Dec 2;23(1):4
Journal of neuroinflammation 2025 Dec 2;23(1):4
Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity.
Li Y, Sheng M, Li W, Liu S, Wang B, Liu B, Luo M, Zhou X, Xia Q, Hong S, Zheng Z, Cheng SY, Jiang X, Li J, Huang T
Nature communications 2025 Dec 13;17(1):440
Nature communications 2025 Dec 13;17(1):440
The FTO Mediated N6-Methyladenosine Modification of DDIT4 Regulation with Tumorigenesis and Metastasis in Prostate Cancer.
Zhao Y, Hu X, Yu H, Sun H, Zhang L, Shao C
Research (Washington, D.C.) 2024;7:0313
Research (Washington, D.C.) 2024;7:0313
mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis.
Zhao S, Hao S, Zhou J, Chen X, Zhang T, Qi Z, Zhang T, Jalal S, Zhai C, Yin L, Bo Y, Teng H, Wang Y, Gao D, Zhang H, Huang L
Cellular & molecular biology letters 2024 Sep 27;29(1):125
Cellular & molecular biology letters 2024 Sep 27;29(1):125
25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages.
Xiao J, Wang S, Chen L, Ding X, Dang Y, Han M, Zheng Y, Shen H, Wu S, Wang M, Yang D, Li N, Dong C, Hu M, Su C, Li W, Hui L, Ye Y, Tang H, Wei B, Wang H
Immunity 2024 May 14;57(5):1087-1104.e7
Immunity 2024 May 14;57(5):1087-1104.e7
Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma.
Li M, Yan X, Liu H, Miao W, Wu W, Zhao Y, Wang C, Liu H
Translational research : the journal of laboratory and clinical medicine 2024 Mar;265:26-35
Translational research : the journal of laboratory and clinical medicine 2024 Mar;265:26-35
MLN4924 Suppresses head and neck squamous cell carcinoma progression by inactivating the mTOR signaling pathway via the NEDD8/CUL4/TSC2 axis.
Jiang Y, Le F, Huang S, Chen X, Deng Z
The international journal of biochemistry & cell biology 2024 Dec;177:106696
The international journal of biochemistry & cell biology 2024 Dec;177:106696
miR-25-5p in exosomes derived from UVB-induced fibroblasts regulates melanogenesis via TSC2-dominated cellular organelle dysfunction.
Yang H, Zhang X, Wang W, Ge Y, Yang Y, Lin T
Journal of dermatological science 2024 Aug;115(2):75-84
Journal of dermatological science 2024 Aug;115(2):75-84
Resistance to anti-HER2 therapy associated with the TSC2 nonsynonymous variant c.4349 C > G (p.Pro1450Arg) is reversed by CDK4/6 inhibitor in HER2-positive breast cancer.
Yang Z, Feng J, Jing J, Huang Y, Ye WW, Lei L, Wang XJ, Cao WM
NPJ breast cancer 2023 May 9;9(1):36
NPJ breast cancer 2023 May 9;9(1):36
Inhibition of autophagy and induction of glioblastoma cell death by NEO214, a perillyl alcohol-rolipram conjugate.
Ou M, Cho HY, Fu J, Thein TZ, Wang W, Swenson SD, Minea RO, Stathopoulos A, Schönthal AH, Hofman FM, Tang L, Chen TC
Autophagy 2023 Dec;19(12):3169-3188
Autophagy 2023 Dec;19(12):3169-3188
A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression.
Yan C, Xiong J, Zhou Z, Li Q, Gao C, Zhang M, Yu L, Li J, Hu MM, Zhang CS, Cai C, Zhang H, Zhang J
eLife 2023 Aug 17;12
eLife 2023 Aug 17;12
Oleanolic Acid Induces Autophagy and Apoptosis via the AMPK-mTOR Signaling Pathway in Colon Cancer.
Hu C, Cao Y, Li P, Tang X, Yang M, Gu S, Xiong K, Li T, Xiao T
Journal of oncology 2021;2021:8281718
Journal of oncology 2021;2021:8281718
Effect of STAT3 mediated epigenetic regulation in pre-eclampsia: an analysis of trial data.
Zhang XL, Pan J, Wang G, Li H, Wang JL, Jiang XM, Zhao XY
European review for medical and pharmacological sciences 2020 Jun;24(11):5843-5855
European review for medical and pharmacological sciences 2020 Jun;24(11):5843-5855
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TSC2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TSC2. This antibody recognizes human antigen. The TSC2 antibody has been validated for the following applications: ELISA, WB analysis.
