orb106932

antibody from Biorbyt

Targeting: TSC2 LAM, PPP1R160, TSC4, tuberin

Western blot (Data presented on provider website)

Antibody Data

Product number

orb106932

Provider

Biorbyt

Product name

TSC2 antibody

Antibody type

Polyclonal

Antigen

Synthetic peptide

Description

Rabbit polyclonal to TSC2. In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Antibody clone number

RB42286

Vial size

80 ul

Storage

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles