PAB16960

antibody from Abnova Corporation

Targeting: TSC2 LAM, PPP1R160, TSC4, tuberin

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

PAB16960

Provider

Abnova Corporation

Proper citation

Abnova Corporation Cat#PAB16960, RRID:AB_10616178

Product name

TSC2 (phospho T1462) polyclonal antibody

Antibody type

Polyclonal

Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of TSC2.

Storage

Store at 4°C for three months. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.

References

Submitted references

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning.

Cai SL, Tee AR, Short JD, Bergeron JM, Kim J, Shen J, Guo R, Johnson CL, Kiguchi K, Walker CL
The Journal of cell biology 2006 Apr 24;173(2):279-89

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Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.

Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J
Proceedings of the National Academy of Sciences of the United States of America 2004 Sep 14;101(37):13489-94

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The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.

Li Y, Inoki K, Vacratsis P, Guan KL
The Journal of biological chemistry 2003 Apr 18;278(16):13663-71

Immunohistochemistry

Supportive validation

Submitted by

Abnova Corporation (provider)

Main image

Experimental details

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using TSC2 (phospho Thr1462) polyclonal antibody (Cat # PAB16960).

Validation comment

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)