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- Antibody Data
- Antigen structure
- References [4]
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- Western blot [1]
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- Product number
- ABIN501073 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Tuberous Sclerosis 2 (TSC2) (C-Term) antibody
- Antibody type
- Polyclonal
- Antigen
- TSC2 antibody was raised against a 15 amino acid peptide from near the carboxy-terminus of human TSC2.
- Description
- Peptide affinity chromatography
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- C-Term
- Isotype
- IgG
- Vial size
- 0.1 mg
- Storage
- Store at 2 - 8°C for up to one month or (in aliquots) at -20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references Signaling by target of rapamycin proteins in cell growth control.
Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K.
Integration of growth factor and nutrient signaling: implications for cancer biology.
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Inoki K, Ouyang H, Li Y, Guan KL
Microbiology and molecular biology reviews : MMBR 2005 Mar;69(1):79-100
Microbiology and molecular biology reviews : MMBR 2005 Mar;69(1):79-100
Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K.
Tabancay AP Jr, Gau CL, Machado IM, Uhlmann EJ, Gutmann DH, Guo L, Tamanoi F
The Journal of biological chemistry 2003 Oct 10;278(41):39921-30
The Journal of biological chemistry 2003 Oct 10;278(41):39921-30
Integration of growth factor and nutrient signaling: implications for cancer biology.
Shamji AF, Nghiem P, Schreiber SL
Molecular cell 2003 Aug;12(2):271-80
Molecular cell 2003 Aug;12(2):271-80
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Inoki K, Li Y, Xu T, Guan KL
Genes & development 2003 Aug 1;17(15):1829-34
Genes & development 2003 Aug 1;17(15):1829-34
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Western blot analysis of TSC2 in L1210 cell lysate with AP30961PU-N at 1 ?g/ml in the (A) absence and (B) presence of blocking peptide.
