FNab09101

antibody from FineTest Biotech
Targeting: TSC2 LAM, PPP1R160, TSC4, tuberin
Provider product page for FNab09101
Western blot
ELISA
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
FNab09101 - Provider product page
Provider
FineTest Biotech
Product name
Tuberin-Specific antibody
Antibody type
Polyclonal
Antigen
Recombinant protein fragment
Description
TSC2, also named as TSC4, FLJ43106 and LAM, acts as a GTPase-activating protein(GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In complex with TSC1, TSC2 inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. TSC2 implicated as a tumor suppressor. It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. TSC2 stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Mutations in either TSC2 or the related TSC1(hamartin) gene cause tuberous sclerosis complex(TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. The antibody is specific to TSC2.
Reactivity
Human, Mouse
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
tuberous sclerosis 2
Epitope
IgG
Isotype
IgG
Vial size
100¦Ìg
Concentration
Immunogen affinity purified
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
TSC2 protein structure - FNab09101 shown in red.