635901

antibody from BioLegend
Targeting: TSC2 LAM, PPP1R160, TSC4, tuberin
Provider product page for 635901
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
635901 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#635901, RRID:AB_961444
Product name
Purified anti-TSC2 Phospho (Ser664)
Antibody type
Polyclonal
Antigen
Modified peptide
Description
Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder that is caused by mutation in either the TSC1 (hamartin) or TSC2 (tuberin) gene. TSC1 and TSC2 proteins form a physical and functional heterodimer in vivo thatinhibits ribosomal protein S6 kinase 1 (S6K1) and activates eukaryotic initiation factor 4E-bindingprotein 1 (4E-BP1) by inhibition of the mammalian target of rapamycin (mTOR). TSC2 belongs to small GTPase protein of the Ras superfamily, contain a Rap-GAP domain. Predicted molecular weight 201 kD. Ser664 TSC2 phosphorylation leads to TSC1-TSC2 dissociation and markedly impairs TSC2 ability to inhibit mTOR signaling, cell proliferation, and oncogenic transformation. Erk (extracellular signal-regulated kinase) may contribute to tumorigenesis by phosphorylating TSC2 at specific residues, particularly S664.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Vial size
25 µl
Storage
Upon receipt, store frozen at -20°C.
TSC2 protein structure - 635901 shown in red.