Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations [0]
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- Product number
- 635902 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#635902, RRID:AB_961443
- Product name
- Purified anti-TSC2 Phospho (Ser664)
- Antibody type
- Polyclonal
- Antigen
- Modified peptide
- Description
- Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder that is caused by mutation in either the TSC1 (hamartin) or TSC2 (tuberin) gene. TSC1 and TSC2 proteins form a physical and functional heterodimer in vivo thatinhibits ribosomal protein S6 kinase 1 (S6K1) and activates eukaryotic initiation factor 4E-bindingprotein 1 (4E-BP1) by inhibition of the mammalian target of rapamycin (mTOR). TSC2 belongs to small GTPase protein of the Ras superfamily, contain a Rap-GAP domain. Predicted molecular weight 201 kD. Ser664 TSC2 phosphorylation leads to TSC1-TSC2 dissociation and markedly impairs TSC2 ability to inhibit mTOR signaling, cell proliferation, and oncogenic transformation. Erk (extracellular signal-regulated kinase) may contribute to tumorigenesis by phosphorylating TSC2 at specific residues, particularly S664.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Vial size
- 100 µl
- Storage
- Upon receipt, store frozen at -20°C.
Submitted references Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling.
Role of the TSC1-TSC2 complex in the integration of insulin and glucose signaling involved in pancreatic beta-cell proliferation.
Miyazaki M, McCarthy JJ, Fedele MJ, Esser KA
The Journal of physiology 2011 Apr 1;589(Pt 7):1831-46
The Journal of physiology 2011 Apr 1;589(Pt 7):1831-46
Role of the TSC1-TSC2 complex in the integration of insulin and glucose signaling involved in pancreatic beta-cell proliferation.
Bartolomé A, Guillén C, Benito M
Endocrinology 2010 Jul;151(7):3084-94
Endocrinology 2010 Jul;151(7):3084-94
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