Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- NBP1-05203 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-05203, RRID:AB_1556319
- Product name
- Mouse Monoclonal MBP Antibody
- Antibody type
- Monoclonal
- Description
- Affinity purified. The MBP Antibody (7G7) antibody binds all four of the CNS MBP isoforms, so that the epitope for the antibody is located in the core shared by all four gene products.
- Reactivity
- Human, Mouse, Rat, Bovine, Porcine
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Netrin-1 Contributes to Myelinated Afferent Fiber Sprouting and Neuropathic Pain.
Phasic Treatment with Interferon Gamma Stimulates Release of Exosomes that Protect Against Spreading Depression.
Spreading depression transiently disrupts myelin via interferon-gamma signaling.
Wu CH, Yuan XC, Gao F, Li HP, Cao J, Liu YS, Yu W, Tian B, Meng XF, Shi J, Pan HL, Li M
Molecular neurobiology 2016 Oct;53(8):5640-51
Molecular neurobiology 2016 Oct;53(8):5640-51
Phasic Treatment with Interferon Gamma Stimulates Release of Exosomes that Protect Against Spreading Depression.
Pusic AD, Kraig RP
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2015 Oct;35(10):795-807
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2015 Oct;35(10):795-807
Spreading depression transiently disrupts myelin via interferon-gamma signaling.
Pusic AD, Mitchell HM, Kunkler PE, Klauer N, Kraig RP
Experimental neurology 2015 Feb;264:43-54
Experimental neurology 2015 Feb;264:43-54
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: MBP Antibody (7G7) [NBP1-05203] - Analysis of different tissue lysates using mouse mAb to MBP, NBP1-05203, dilution 1:20,000 in green: [1] protein standard (red), [2] rat brain, [3] rat spinal cord, [4] rat sciatic nerve, [5] mouse brain, [6] mouse spinal cord. Multiple bands at 14kDa, 17kDa, 18.5kDa to 21.5kDa are the alternate transcripts of MBP. Other bands are proteolytic fragments of the MBP protein.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: MBP Antibody (7G7) [NBP1-05203] - Analysis of rat hippocampal section stained with mouse mAb to myelin basic protein (MBP), NBP1-05203, dilution 1:5,000 in green, and costained with rabbit pAb to neurofilament NF-H, dilution 1:2,000, in red. The MBP antibody stains oligodendrocyte cell bodies and the myelin sheathes around axons, while the NF-H antibody labels the axons themselves.