MAB377-100

antibody from R&D Systems

Targeting: NRG1 GGF, HGL, HRG, NDF, NRG1-IT2

Western blot (Data presented on provider website)

Antibody Data

Product number

MAB377-100

Provider

R&D Systems

Product name

Human Neuregulin-1/NRG1 Antibody

Antibody type

Monoclonal

Description

Protein A or G purified from hybridoma culture supernatant. Detects human Neuregulin-1/NRG1 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with the EGF-like domains of recombinant human (rh) NRG1-beta 1 (aa 176-246) or rhNRG1-alpha (aa 177-241). Therefore, this antibody recognizes an epitope located within aa 2-176 segment N-terminal to the EGF-like domain. This segment is present in all NRG1-alpha , beta and gamma isoforms and in NDF43 and glial growth factor (GGF). It is absent from the NRG1 gene products GGF2 and SMDF.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

AAA58639


Isotype

IgG

Antibody clone number

147724

Vial size

100 ug

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.

Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, Wang D, Gao Y, Zhu Y, Sheng X, Chen K, Wang N, Zhu L, Can D, Marten Y, Shinohara M, Liu CC, Du D, Sun H, Wen L, Xu H, Bu G, Chen XF
Nature communications 2019 Mar 25;10(1):1365

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BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors.

Rhyasen GW, Yao Y, Zhang J, Dulak A, Castriotta L, Jacques K, Zhao W, Gharahdaghi F, Hattersley MM, Lyne PD, Clark E, Zinda M, Fawell SE, Mills GB, Chen H
PloS one 2018;13(7):e0200826

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Expression of the neuroprotective protein aryl hydrocarbon receptor nuclear translocator 2 correlates with neuronal stress and disability in models of multiple sclerosis.

Rahim T, Becquart P, Baeva ME, Quandt J
Journal of neuroinflammation 2018 Sep 19;15(1):270

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Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury.

Choi YK, Maki T, Mandeville ET, Koh SH, Hayakawa K, Arai K, Kim YM, Whalen MJ, Xing C, Wang X, Kim KW, Lo EH
Nature medicine 2016 Nov;22(11):1335-1341

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Fibroblast-derived neuregulin 1 promotes compensatory ErbB3 receptor signaling in mutant BRAF melanoma.

Capparelli C, Rosenbaum S, Berger AC, Aplin AE
The Journal of biological chemistry 2015 Oct 2;290(40):24267-77

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BRCA1-IRIS inactivation sensitizes ovarian tumors to cisplatin.

Paul BT, Blanchard Z, Ridgway M, ElShamy WM
Oncogene 2015 Jun 4;34(23):3036-52

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The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene.

Chua YL, Ito Y, Pole JC, Newman S, Chin SF, Stein RC, Ellis IO, Caldas C, O'Hare MJ, Murrell A, Edwards PA
Oncogene 2009 Nov 19;28(46):4041-52

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Fractalkine/CX3CL1 enhances GABA synaptic activity at serotonin neurons in the rat dorsal raphe nucleus.

Heinisch S, Kirby LG
Neuroscience 2009 Dec 15;164(3):1210-23