Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
DCC
DCC netrin 1 receptorIGDCC1, NTN1R1
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
Top validated antibodies |
|||||
| antibodies-online |  ABIN953653 |
2 references | Polyclonal |
WB
IHC
|
|
| Invitrogen Antibodies | PA5-50946 |
1 references | Polyclonal |
WB
EL
OA
|
|
| HUABIO Research | 0911-5 |
Polyclonal |
WB
ICC
IHC
FC
|
||
| Proteintech Group | 19123-1-AP |
2 references | Polyclonal |
WB
EL
|
|
| R&D Systems | AF844 |
6 references | Polyclonal |
WB
BN
|
|
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive) Recommended by provider