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- References [124]
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- Product number
- 10231-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10231-1-AP, RRID:AB_2193323
- Product name
- SMAD4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SMAD4 antibody (Cat. #10231-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The TPx protein of Taenia solium metacestode regulates Treg and Th17 cell differentiation via the TGF-β/Smad signaling pathway.
FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression.
HDAC6 orchestrates metastatic and immunosuppressive programs in small cell lung cancer through S100A2-TGF-β/SMAD and CSF1R signaling.
CDK5RAP3 Regulates Testosterone Production in Mouse Leydig Cells.
SENP6-mediated desumoylation of SMAD5 regulates osteogenic fate in periodontal ligament stem cells.
PARP1 stabilizes FOXN3 to suppress pulmonary fibrosis through p38-related feedback regulation.
Exercise-induced extracellular vesicles derived from platelet-rich plasma improved recovery after ischemic stroke.
Modulation of endothelial-to-mesenchymal transition via NRP-1 targeting with melittin attenuates pulmonary fibrosis.
The D2.B10-Dmd(mdx)/J Mouse Model of Duchenne Muscular Dystrophy Exhibits a Severe Mitochondrial Deficiency Not Observed in the C57BL/10ScSn-Dmd(mdx)/J Mouse.
TGF-β/LAMB3 axis drives ROS-dependent renal fibrosis under hypoxic conditions.
SMAD4 Inhibits HO-1-Driven Ferroptosis Through Transcriptional Repression in Sepsis-Associated Acute Kidney Injury.
Lathyrol inhibits the proliferation of Renca cells by altering expression of TGF-β/Smad pathway components and subsequently affecting the cell cycle.
Kisspeptin Suppresses the Growth of Primary Pterygial Cells via Inhibiting Chemokine (C-X-C Motif) Ligands in Microenvironment.
Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.
Rhein alleviates renal interstitial fibrosis by inhibiting Smad3 phosphorylation in TGF-β/Smad signalling pathway.
Fecal Microbiota Transplantation Attenuated Inflammation Through TGF-β1/Smad Signaling Pathway in Caco-2 and RAW264.7 Cells.
miR-370-3p Inhibited the Proliferation of Sheep Dermal Papilla Cells by Inhibiting the Expression of SMAD4.
CD39 Contributes to the Ability of Cell Invasion in Heterogeneity of Colorectal Cancer.
CD4(+) anti-TGF-β CAR T cells and CD8(+) conventional CAR T cells exhibit synergistic antitumor effects.
Shuangshi Tonglin Capsule Improves Prostate Fibrosis through Nrf2/TGF-β1 Signaling Pathways.
Pilot Exploration of RGMa-BMP4 Signaling in Neutrophil Activation in NMOSD: Integrating Clinical and Molecular Insights.
PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation.
The role of apoptosis, immunogenic cell death, and macrophage polarization in carbon ion radiotherapy for keloids: Targeting the TGF-β1/SMADs signaling pathway.
FOXP1 is a Transcription Factor for the Alzheimer's Disease Risk Gene SORL1.
Roles of B-cell lymphoma 6 in orthodontic tooth movement of rat molars.
Phosphorylation of FOXN3 by NEK6 promotes pulmonary fibrosis through Smad signaling.
DTL promotes pancreatic cancer progression through ubiquitin-mediated degradation of SMAD4.
AMPK regulates the anti-pulmonary fibrosis effects of tracheloside.
m6A mRNA demethylase FTO promotes chondrogenic differentiation of human bone marrow mesenchymal stem cells by targeting SMAD3.
Mesenteric adipose-derived exosomal TINAGL1 enhances intestinal fibrosis in Crohn's Disease via SMAD4.
N6-Methyladenosine-Modified circSMAD4 Prevents Lumbar Instability Induced Cartilage Endplate Ossification.
The Epstein-Barr virus-miRNA-BART6-5p regulates TGF-β/SMAD4 pathway to induce glycolysis and enhance proliferation and metastasis of gastric cancer cells.
Anticancer Effects of Weizmannia coagulans MZY531 Postbiotics in CT26 Colorectal Tumor-Bearing Mice by Regulating Apoptosis and Autophagy.
Role and action mechanisms of miR-149 and miR-31 in regulating function of pig cumulus cells and oocytes.
The circadian clock gene, BMAL1, promotes radiosensitization in nasopharyngeal carcinoma by inhibiting the epithelial-to-mesenchymal transition via the TGF-β1/Smads/Snail1 axis.
Anticancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer.
Role of thrombospondin-1 in high-salt-induced mesenteric artery endothelial impairment in rats.
Structural characterization of an inulin neoseries-type fructan from Ophiopogonis Radix and the therapeutic effect on liver fibrosis in vivo.
HnRNPA2B1 ISGylation Regulates m6A-Tagged mRNA Selective Export via ALYREF/NXF1 Complex to Foster Breast Cancer Development.
Sodium arsenite induces hepatic stellate cells activation by m(6)A modification of TGF-β1 during liver fibrosis.
MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction.
Regulation of the immune microenvironment by pioglitazone-loaded polylactic glycolic acid nanosphere composite scaffolds to promote vascularization and bone regeneration.
The SIRT1/Nrf2 signaling pathway mediates the anti-pulmonary fibrosis effect of liquiritigenin.
Oncostatin M/Oncostatin M Receptor Signal Induces Radiation-Induced Heart Fibrosis by Regulating SMAD4 in Fibroblast.
ALA-PDT promotes the death and contractile capacity of hypertrophic scar fibroblasts through inhibiting the TGF-β1/Smad2/3/4 signaling pathway.
A dihydromyricetin-loaded phellinus igniarius polysaccharide/l-arginine modified chitosan-based hydrogel for promoting wound recovery in diabetic mice via JNK and TGF-β/Smad signaling pathway.
miR-6881-3p contributes to diminished ovarian reserve by regulating granulosa cell apoptosis by targeting SMAD4.
IBSP Promotes Breast Cancer Bone Metastasis and Proliferation via BMP-SMAD Signaling Pathway.
Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity.
Knockdown of long noncoding RNA AL161431.1 inhibits malignant progression of cholangiocarcinoma.
Effect of matrine in MAC-T cells and their transcriptome analysis: A basic study.
Irisin Ameliorates Renal Tubulointerstitial Fibrosis by Regulating the Smad4/β-Catenin Pathway in Diabetic Mice.
Linc-ROR Promotes EMT by Targeting miR-204-5p/SMAD4 in Endometriosis.
KMT2A associates with PHF5A-PHF14-HMG20A-RAI1 subcomplex in pancreatic cancer stem cells and epigenetically regulates their characteristics.
Hsa-miR-27b-5p suppresses the osteogenic and odontogenic differentiation of stem cells from human exfoliated deciduous teeth via targeting BMPR1A: An ex vivo study.
Paroxetine protects against bleomycin-induced pulmonary fibrosis by blocking GRK2/Smad3 pathway.
Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3.
Possible mechanisms associated with immune escape and apoptosis on anti-hepatocellular carcinoma effect of Mu Ji Fang granules.
Benzylisoquinoline alkaloids inhibit lung fibroblast activation mainly via inhibiting TGF-β1/Smads and ERK1/2 pathway proteins.
Resveratrol plays an anti-fibrotic and anti-autophagy role by stimulating miR-192-5p expression in urethral fibrosis.
BMP4/SMAD8 signaling pathway regulated granular cell proliferation to promote follicle development in Wanxi white goose.
Trigonelline inhibits tubular epithelial-mesenchymal transformation in diabetic kidney disease via targeting Smad7.
Profibrotic role of transcription factor SP1 in cross-talk between fibroblasts and M2 macrophages.
Cell Cycle-Related FAM64A Could be Activated by TGF-β Signaling to Promote Glioma Progression.
USP25 inhibits renal fibrosis by regulating TGFβ-SMAD signaling pathway in Ang II-induced hypertensive mice.
SUMOylation of SMAD4 by PIAS1 in Conjunction with Vimentin Upregulation Promotes Migration Potential in Non-Small Cell Lung Cancer.
Qianjin Wenwu decoction suppresses renal interstitial fibrosis by enhancing the degradation of extracellular matrix in mice with unilateral ureteral obstruction.
Smad7 Is Highly Expressed in Human Degenerative Discs and Participates in IL-1β-Induced Apoptosis of Rat AF Cells via the Mitochondria Pathway.
Bu-Gu-Sheng-Sui decoction promotes osteogenesis via activating the ERK/Smad signaling pathways.
Post-translational control of beige fat biogenesis by PRDM16 stabilization.
TRIM47 promotes glioma angiogenesis by suppressing Smad4.
Apigenin inhibits fibrous scar formation after acute spinal cord injury through TGFβ/SMADs signaling pathway.
SMAD4 Inhibits Granulosa Cell Apoptosis via the miR-183-96-182 Cluster and FoxO1 Axis.
Nicotinamide N-methyltransferase ameliorates renal fibrosis by its metabolite 1-methylnicotinamide inhibiting the TGF-β1/Smad3 pathway.
Gli(ko) BMSC: A potential strategy of treatment for renal fibrosis.
Multi-material basis and multi-mechanisms of the Dahuang Zhechong pill for regulating Treg/Th1 balance in hepatocellular carcinoma.
The Photoperiod Regulates Granulosa Cell Apoptosis through the FSH-Nodal/ALK7 Signaling Pathway in Phodopus sungorus.
Agmatinase facilitates the tumorigenesis of pancreatic adenocarcinoma through the TGFβ/Smad pathway.
Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy.
Systematic Survey of the Regulatory Networks of the Long Noncoding RNA BANCR in Cervical Cancer Cells.
The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells.
Pilose Antler Peptide-3.2KD Ameliorates Adriamycin-Induced Myocardial Injury Through TGF-β/SMAD Signaling Pathway.
FOXM1-induced miR-552 expression contributes to pancreatic cancer progression by targeting multiple tumor suppressor genes.
Huangqi Shengmai Yin Ameliorates Myocardial Fibrosis by Activating Sirtuin3 and Inhibiting TGF-β/Smad Pathway.
Hsa_circ_0001021 regulates intestinal epithelial barrier function via sponging miR-224-5p in ulcerative colitis.
SMAD4 Feedback Activates the Canonical TGF-β Family Signaling Pathways.
Smad4 deficiency substitutes Cdkn2b but not Cdkn2a downregulation in pancreatic cancer following induction of genetic events in adult mice.
MiR-664-3p suppresses osteoblast differentiation and impairs bone formation via targeting Smad4 and Osterix.
A mesenchymal-like subpopulation in non-neuroendocrine SCLC contributes to metastasis.
SEPHS1 promotes SMAD2/3/4 expression and hepatocellular carcinoma cells invasion.
Comparison of anticarcinogenic properties of Viburnum opulus and its active compound p-coumaric acid on human colorectal carcinoma.
Novel Alternatively Spliced Variants of Smad4 Expressed in TGF-β-Induced EMT Regulating Proliferation and Migration of A549 Cells.
Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1.
Deubiquitinase USP13 promotes extracellular matrix expression by stabilizing Smad4 in lung fibroblast cells.
KDM6A suppresses hepatocellular carcinoma cell proliferation by negatively regulating the TGF-β/SMAD signaling pathway.
Schisandrin B regulates MC3T3-E1 subclone 14 cells proliferation and differentiation through BMP2-SMADs-RUNX2-SP7 signaling axis.
Small airway remodeling in diabetic and smoking chronic obstructive pulmonary disease patients.
Co-transplantation with adipose-derived cells to improve parathyroid transplantation in a mice model.
Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-β1 pathway and interfering with MMP-TIMPs expression.
Promotion effects of mono-2-ethyhexyl phthalate (MEHP) on migration and invasion of human melanoma cells via activation of TGF-β signals.
Transactivation of miR-202-5p by Steroidogenic Factor 1 (SF1) Induces Apoptosis in Goat Granulosa Cells by Targeting TGFβR2.
β2-microglobulin as a biomarker of pulmonary fibrosis development in COPD patients.
Exosome-mediated Hic-5 regulates proliferation and apoptosis of osteosarcoma via Wnt/β-catenin signal pathway.
Overexpression of matrix metalloproteinase-9 in breast cancer cell lines remarkably increases the cell malignancy largely via activation of transforming growth factor beta/SMAD signalling.
Oviductus Ranae protein hydrolyzate prevents menopausal osteoporosis by regulating TGFβ/BMP2 signaling.
The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis.
miR-93-5p targets Smad7 to regulate the transforming growth factor-β1/Smad3 pathway and mediate fibrosis in drug-resistant prolactinoma.
Myostatin/SMAD4 signaling-mediated regulation of miR-124-3p represses glucocorticoid receptor expression and inhibits adipocyte differentiation.
Inhibition of Skp1-Cullin-F-box complexes during bovine oocyte maturation and preimplantation development leads to delayed development of embryos†.
Transcription coactivator Cited1 acts as an inducer of trophoblast-like state from mouse embryonic stem cells through the activation of BMP signaling.
Inhibition of lysyl oxidase expression by dextran sulfate affects invasion and migration of gastric cancer cells.
Role of TGF-β1/Smad3-mediated fibrosis in drug resistance mechanism of prolactinoma.
MicroRNA-140 Inhibits the Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.
SIRT7 suppresses the epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis by promoting SMAD4 deacetylation.
Inhibiting transforming growth factor-β signaling regulates in vitro maintenance and differentiation of bovine bone marrow mesenchymal stem cells.
Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients.
TGFβ1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer.
Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGFβ2 feedback loop.
Decrease of FSTL1-BMP4-Smad signaling predicts poor prognosis in lung adenocarcinoma but not in squamous cell carcinoma.
Prognostic Value of SMAD4 in Pancreatic Cancer: A Meta-Analysis.
Let‑7a suppresses cell proliferation via the TGF‑β/SMAD signaling pathway in cervical cancer.
Anti-fibrotic effects of neferine on carbon tetrachloride-induced hepatic fibrosis in mice.
Biomarkers of TGF-β signaling pathway and prognosis of pancreatic cancer.
Aberrant elevated microRNA-146a in dendritic cells (DC) induced by human pancreatic cancer cell line BxPC-3-conditioned medium inhibits DC maturation and activation.
Sun X, Mu Q, Zhou B
Frontiers in immunology 2026;17:1612077
Frontiers in immunology 2026;17:1612077
FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression.
Qin J, Ma S, Wang J, Huang S, Luan J, He J, Hou G, Sun N, Zhang W, Gao M
Cell death & disease 2026 Mar 20;17(1)
Cell death & disease 2026 Mar 20;17(1)
HDAC6 orchestrates metastatic and immunosuppressive programs in small cell lung cancer through S100A2-TGF-β/SMAD and CSF1R signaling.
Jiang Y, Yu J, Wang T, Du Q, Wang J, Lu Y, Xu Q, Liu H, Li X, Tong L, Qin T, Huang D
Molecular cancer 2026 Jan 7;25(1):33
Molecular cancer 2026 Jan 7;25(1):33
CDK5RAP3 Regulates Testosterone Production in Mouse Leydig Cells.
Ruan J, Dong Q, Jin Y, Yang Y, Li J, Cai Y
International journal of molecular sciences 2026 Jan 6;27(2)
International journal of molecular sciences 2026 Jan 6;27(2)
SENP6-mediated desumoylation of SMAD5 regulates osteogenic fate in periodontal ligament stem cells.
Jin H, Liu C, Wang W, Xie H, Ji B, Wei W, Wang X
European journal of medical research 2026 Jan 30;31(1)
European journal of medical research 2026 Jan 30;31(1)
PARP1 stabilizes FOXN3 to suppress pulmonary fibrosis through p38-related feedback regulation.
Zhu X, Huo Q, Jin L, Du J, Yu J, Wang H, Wu N, Li Y, Rui Y, Zhao C, Zhou J, Zhang Y, Li H, Lin J, Zheng C, Li W
Science advances 2026 Jan 2;12(1):eady1681
Science advances 2026 Jan 2;12(1):eady1681
Exercise-induced extracellular vesicles derived from platelet-rich plasma improved recovery after ischemic stroke.
Miyauchi Y, Miyamoto N, Inaba T, Xu HB, Kijima C, Hira K, Hattori N, Ueno Y
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2026 Feb;46(2):359-376
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2026 Feb;46(2):359-376
Modulation of endothelial-to-mesenchymal transition via NRP-1 targeting with melittin attenuates pulmonary fibrosis.
Hu M, Wan Y, Chen J, Zhang C, Li S, Shan B, Wu L, Yu X
Materials today. Bio 2026 Feb;36:102659
Materials today. Bio 2026 Feb;36:102659
The D2.B10-Dmd(mdx)/J Mouse Model of Duchenne Muscular Dystrophy Exhibits a Severe Mitochondrial Deficiency Not Observed in the C57BL/10ScSn-Dmd(mdx)/J Mouse.
Tinklenberg JA, Sutton J, Slick RA, Meng H, Haberman M, Prom MJ, Beatka MJ, Vetter TA, Daugherty AL, Pacak CA, Gonzalez JP, Lawlor MW
The American journal of pathology 2026 Feb;196(2):532-549
The American journal of pathology 2026 Feb;196(2):532-549
TGF-β/LAMB3 axis drives ROS-dependent renal fibrosis under hypoxic conditions.
Wu Z, Kuang Z, Liang L, Liu J, Wang G, Zou F
Free radical biology & medicine 2026 Feb 16;244:395-409
Free radical biology & medicine 2026 Feb 16;244:395-409
SMAD4 Inhibits HO-1-Driven Ferroptosis Through Transcriptional Repression in Sepsis-Associated Acute Kidney Injury.
Han Z, Li J, Guan C, Quan Z, Zeng S, Li Y, Wen L, Bai J, Zheng J, Wang H
Antioxidants & redox signaling 2026 Apr 17;:15230864261443829
Antioxidants & redox signaling 2026 Apr 17;:15230864261443829
Lathyrol inhibits the proliferation of Renca cells by altering expression of TGF-β/Smad pathway components and subsequently affecting the cell cycle.
Song S, Song Y
Frontiers in oncology 2025;15:1629962
Frontiers in oncology 2025;15:1629962
Kisspeptin Suppresses the Growth of Primary Pterygial Cells via Inhibiting Chemokine (C-X-C Motif) Ligands in Microenvironment.
Wu P, Liu S, Xu T, Zhao G
Current eye research 2025 Sep;50(9):894-902
Current eye research 2025 Sep;50(9):894-902
Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.
Ma Y, Huang J, Gong J, Li L, Zhao Y, Jin Y, Gu J, Liu H, Wang Y, Sun Y
Chinese medicine 2025 Sep 22;20(1):146
Chinese medicine 2025 Sep 22;20(1):146
Rhein alleviates renal interstitial fibrosis by inhibiting Smad3 phosphorylation in TGF-β/Smad signalling pathway.
Zheng X, Wang L, Cheng Y, Lin H, Liu S, Chen X, Xiang Z
Chinese herbal medicines 2025 Oct;17(4):744-755
Chinese herbal medicines 2025 Oct;17(4):744-755
Fecal Microbiota Transplantation Attenuated Inflammation Through TGF-β1/Smad Signaling Pathway in Caco-2 and RAW264.7 Cells.
Qiu J, Wu C, Li S, Yang X
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2025 Oct 10;37(2):161-169
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2025 Oct 10;37(2):161-169
miR-370-3p Inhibited the Proliferation of Sheep Dermal Papilla Cells by Inhibiting the Expression of SMAD4.
Fu J, Wang D, Liu W, Qi Y, Zhang C, Li H, Cai J, Ji S, Zhang L, Sun F
Cells 2025 May 14;14(10)
Cells 2025 May 14;14(10)
CD39 Contributes to the Ability of Cell Invasion in Heterogeneity of Colorectal Cancer.
Li X, Shen Y, Lang J, Wu J, Qian Z, Shen G, Shen Y
Journal of cellular and molecular medicine 2025 Mar;29(5):e70486
Journal of cellular and molecular medicine 2025 Mar;29(5):e70486
CD4(+) anti-TGF-β CAR T cells and CD8(+) conventional CAR T cells exhibit synergistic antitumor effects.
Zheng D, Qin L, Lv J, Che M, He B, Zheng Y, Lin S, Qi Y, Li M, Tang Z, Wang BC, Wu YL, Weinkove R, Carson G, Yao Y, Wong N, Lau J, Thiery JP, Qin D, Pan B, Xu K, Zhang Z, Li P
Cell reports. Medicine 2025 Mar 18;6(3):102020
Cell reports. Medicine 2025 Mar 18;6(3):102020
Shuangshi Tonglin Capsule Improves Prostate Fibrosis through Nrf2/TGF-β1 Signaling Pathways.
Wang ZQ, Mao P, Wang BA, Guo Q, Liu H, Yuan Y, Wang C, Liu JP, Zhu XM, Wei H
Chinese journal of integrative medicine 2025 Jun;31(6):518-528
Chinese journal of integrative medicine 2025 Jun;31(6):518-528
Pilot Exploration of RGMa-BMP4 Signaling in Neutrophil Activation in NMOSD: Integrating Clinical and Molecular Insights.
Zhang W, Cui L, Zhang Y, He Y, Li X, Wang Y, Jiao J, Peng D, Jin M, Xiao C
Molecular neurobiology 2025 Jul;62(7):9151-9161
Molecular neurobiology 2025 Jul;62(7):9151-9161
PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation.
He L, Wen J, Dai Q
eLife 2025 Jul 14;14
eLife 2025 Jul 14;14
The role of apoptosis, immunogenic cell death, and macrophage polarization in carbon ion radiotherapy for keloids: Targeting the TGF-β1/SMADs signaling pathway.
Zhou H, Yang P, Zhang T, Kepp O, Ren Y, Jiang N, Liu R, Li J, Li C
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167499
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167499
FOXP1 is a Transcription Factor for the Alzheimer's Disease Risk Gene SORL1.
Fu X, Quan S, Liang W, Li Y, Cai H, Ren Z, Xu Y, Wang Z, Jia L
Journal of neurochemistry 2025 Feb;169(2):e70011
Journal of neurochemistry 2025 Feb;169(2):e70011
Roles of B-cell lymphoma 6 in orthodontic tooth movement of rat molars.
Sodsook W, Kobayashi Y, Kamimoto H, Niki Y, Yokoo K, Chantarawaratit PO, Moriyama K
European journal of orthodontics 2025 Feb 7;47(2)
European journal of orthodontics 2025 Feb 7;47(2)
Phosphorylation of FOXN3 by NEK6 promotes pulmonary fibrosis through Smad signaling.
Yu J, Li Y, Li Y, Liu X, Huo Q, Wu N, Zhang Y, Zeng T, Zhang Y, Li HY, Lian J, Zhou J, Moses EJ, Geng J, Lin J, Li W, Zhu X
Nature communications 2025 Feb 21;16(1):1865
Nature communications 2025 Feb 21;16(1):1865
DTL promotes pancreatic cancer progression through ubiquitin-mediated degradation of SMAD4.
Pan XZ, Tang K, Ren LK, Chen SJ, Chen S, Li SY, Ni RJ, Zhu CH, Wang X, Pan YZ
International journal of biological macromolecules 2025 Dec;333(Pt 2):148692
International journal of biological macromolecules 2025 Dec;333(Pt 2):148692
AMPK regulates the anti-pulmonary fibrosis effects of tracheloside.
Li S, Qian R, Xie W, Lin M, Huang X, Deng L, Xiong D, Liu W, Tang S
Chinese journal of natural medicines 2025 Dec;23(12):100005
Chinese journal of natural medicines 2025 Dec;23(12):100005
m6A mRNA demethylase FTO promotes chondrogenic differentiation of human bone marrow mesenchymal stem cells by targeting SMAD3.
Shu T, Zhang D, Li J, Liu H, Cui L, Gu J, Wu L, Liu W, Wan J, Zheng X
Stem cells (Dayton, Ohio) 2025 Aug 22;43(9)
Stem cells (Dayton, Ohio) 2025 Aug 22;43(9)
Mesenteric adipose-derived exosomal TINAGL1 enhances intestinal fibrosis in Crohn's Disease via SMAD4.
Chen Y, Li J, Zhang X, Li S, Cheng Y, Fu X, Li J, Zhu L
Journal of advanced research 2025 Apr;70:139-158
Journal of advanced research 2025 Apr;70:139-158
N6-Methyladenosine-Modified circSMAD4 Prevents Lumbar Instability Induced Cartilage Endplate Ossification.
Li H, Tang Y, Hu S, Ruan X, Zhang J, Shi Y, Qiu L, Yang H, Zhang K, Chen H, Chen K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2413970
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2413970
The Epstein-Barr virus-miRNA-BART6-5p regulates TGF-β/SMAD4 pathway to induce glycolysis and enhance proliferation and metastasis of gastric cancer cells.
Zhao X, Huang X, Dang C, Wang X, Qi Y, Li H
Oncology research 2024;32(5):999-1009
Oncology research 2024;32(5):999-1009
Anticancer Effects of Weizmannia coagulans MZY531 Postbiotics in CT26 Colorectal Tumor-Bearing Mice by Regulating Apoptosis and Autophagy.
Zhong B, Zhao Y, Gao L, Yang G, Gao Y, Li F, Li S
Life (Basel, Switzerland) 2024 Oct 19;14(10)
Life (Basel, Switzerland) 2024 Oct 19;14(10)
Role and action mechanisms of miR-149 and miR-31 in regulating function of pig cumulus cells and oocytes.
Wu JS, Gong S, Zhang M, Ma RJ, Wang HL, Luo MJ, He N, Tan JH
Theriogenology 2024 May;220:84-95
Theriogenology 2024 May;220:84-95
The circadian clock gene, BMAL1, promotes radiosensitization in nasopharyngeal carcinoma by inhibiting the epithelial-to-mesenchymal transition via the TGF-β1/Smads/Snail1 axis.
Li Y, Zhou Y, Zhao C, Liu L, He Q, Shang K, Xu X, Luo X, Zhou D, Jin F
Oral oncology 2024 May;152:106798
Oral oncology 2024 May;152:106798
Anticancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer.
Yu S, Liao R, Bai L, Guo M, Zhang Y, Zhang Y, Yang Q, Song Y, Li Z, Meng Q, Wang S, Huang X
Drug delivery and translational research 2024 May;14(5):1352-1369
Drug delivery and translational research 2024 May;14(5):1352-1369
Role of thrombospondin-1 in high-salt-induced mesenteric artery endothelial impairment in rats.
Xu FF, Zheng F, Chen Y, Wang Y, Ma SB, Ding W, Zhang LS, Guo JZ, Zheng CB, Shen B
Acta pharmacologica Sinica 2024 Mar;45(3):545-557
Acta pharmacologica Sinica 2024 Mar;45(3):545-557
Structural characterization of an inulin neoseries-type fructan from Ophiopogonis Radix and the therapeutic effect on liver fibrosis in vivo.
Liu W, Zhang L, Wei X, Xu Y, Fang Q, Qi S, Chen J, Wang C, Wang S, Qin L, Liu P, Wu J
Carbohydrate polymers 2024 Mar 1;327:121659
Carbohydrate polymers 2024 Mar 1;327:121659
HnRNPA2B1 ISGylation Regulates m6A-Tagged mRNA Selective Export via ALYREF/NXF1 Complex to Foster Breast Cancer Development.
Jin T, Yang L, Chang C, Luo H, Wang R, Gan Y, Sun Y, Guo Y, Tang R, Chen S, Meng D, Dai P, Liu M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(24):e2307639
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(24):e2307639
Sodium arsenite induces hepatic stellate cells activation by m(6)A modification of TGF-β1 during liver fibrosis.
Qiu T, Hou K, Zhang J, Wang N, Yao X, Yang G, Jiang L, Dong J, Miao M, Bai J, Sun X
Ecotoxicology and environmental safety 2024 Jun 15;278:116435
Ecotoxicology and environmental safety 2024 Jun 15;278:116435
MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction.
Guo L, Li K, Ma Y, Niu H, Li J, Shao X, Li N, Sun Y, Wang H
Human cell 2024 Jul;37(4):972-985
Human cell 2024 Jul;37(4):972-985
Regulation of the immune microenvironment by pioglitazone-loaded polylactic glycolic acid nanosphere composite scaffolds to promote vascularization and bone regeneration.
Fan S, Tan Y, Yuan X, Liu C, Wu X, Dai T, Ni S, Wang J, Weng Y, Zhao H
Journal of tissue engineering 2024 Jan-Dec;15:20417314241231452
Journal of tissue engineering 2024 Jan-Dec;15:20417314241231452
The SIRT1/Nrf2 signaling pathway mediates the anti-pulmonary fibrosis effect of liquiritigenin.
Hua Q, Ren L
Chinese medicine 2024 Jan 18;19(1):12
Chinese medicine 2024 Jan 18;19(1):12
Oncostatin M/Oncostatin M Receptor Signal Induces Radiation-Induced Heart Fibrosis by Regulating SMAD4 in Fibroblast.
Xu P, Yi Y, Xiong L, Luo Y, Xie C, Luo D, Zeng Z, Liu A
International journal of radiation oncology, biology, physics 2024 Jan 1;118(1):203-217
International journal of radiation oncology, biology, physics 2024 Jan 1;118(1):203-217
ALA-PDT promotes the death and contractile capacity of hypertrophic scar fibroblasts through inhibiting the TGF-β1/Smad2/3/4 signaling pathway.
Qu Z, Chen Y, Du K, Qiao J, Chen L, Chen J, Wei L
Photodiagnosis and photodynamic therapy 2024 Feb;45:103915
Photodiagnosis and photodynamic therapy 2024 Feb;45:103915
A dihydromyricetin-loaded phellinus igniarius polysaccharide/l-arginine modified chitosan-based hydrogel for promoting wound recovery in diabetic mice via JNK and TGF-β/Smad signaling pathway.
Yang J, Zhang L, Sun S, Zhang S, Ding Q, Chai G, Yu W, Zhao T, Shen L, Gao Y, Liu W, Ding C
International journal of biological macromolecules 2024 Feb;259(Pt 1):129124
International journal of biological macromolecules 2024 Feb;259(Pt 1):129124
miR-6881-3p contributes to diminished ovarian reserve by regulating granulosa cell apoptosis by targeting SMAD4.
Ju W, Zhao S, Wu H, Yu Y, Li Y, Liu D, Lian F, Xiang S
Reproductive biology and endocrinology : RB&E 2024 Feb 1;22(1):17
Reproductive biology and endocrinology : RB&E 2024 Feb 1;22(1):17
IBSP Promotes Breast Cancer Bone Metastasis and Proliferation via BMP-SMAD Signaling Pathway.
Ding W, Lv D, Wang M, Pei D
Cancer reports (Hoboken, N.J.) 2024 Aug;7(8):e2153
Cancer reports (Hoboken, N.J.) 2024 Aug;7(8):e2153
Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity.
Fang L, Liu C, Jiang ZZ, Wang M, Geng K, Xu Y, Zhu Y, Fu Y, Xue J, Shan W, Zhang Q, Chen J, Chen J, Zhao M, Guo Y, Siu KWM, Chen YE, Xu Y, Liu D, Zheng L
Signal transduction and targeted therapy 2024 Aug 23;9(1):218
Signal transduction and targeted therapy 2024 Aug 23;9(1):218
Knockdown of long noncoding RNA AL161431.1 inhibits malignant progression of cholangiocarcinoma.
Bai Z, Tian N, Ding Z, Lu Q, Wang Y, Du S, Hui Y
Aging 2024 Aug 1;16(15):11501-11512
Aging 2024 Aug 1;16(15):11501-11512
Effect of matrine in MAC-T cells and their transcriptome analysis: A basic study.
Zhang Z, Yang Y, Yan L, Wan X, Sun K, Gou H, Ding J, Peng J, Liu G, Wang C
PloS one 2023;18(1):e0280905
PloS one 2023;18(1):e0280905
Irisin Ameliorates Renal Tubulointerstitial Fibrosis by Regulating the Smad4/β-Catenin Pathway in Diabetic Mice.
Yang Z, Wei J, Wang Y, Du Y, Song S, Li J, Su Z, Shi Y, Wu H
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:1577-1593
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:1577-1593
Linc-ROR Promotes EMT by Targeting miR-204-5p/SMAD4 in Endometriosis.
Yi M, Wang S, Zhang X, Jiang L, Xia X, Zhang T, Fang X
Reproductive sciences (Thousand Oaks, Calif.) 2023 Sep;30(9):2665-2679
Reproductive sciences (Thousand Oaks, Calif.) 2023 Sep;30(9):2665-2679
KMT2A associates with PHF5A-PHF14-HMG20A-RAI1 subcomplex in pancreatic cancer stem cells and epigenetically regulates their characteristics.
Mouti MA, Deng S, Pook M, Malzahn J, Rendek A, Militi S, Nibhani R, Soonawalla Z, Oppermann U, Hwang CI, Pauklin S
Nature communications 2023 Sep 14;14(1):5685
Nature communications 2023 Sep 14;14(1):5685
Hsa-miR-27b-5p suppresses the osteogenic and odontogenic differentiation of stem cells from human exfoliated deciduous teeth via targeting BMPR1A: An ex vivo study.
Guo R, Gu T, Xiao Y, Xiao T, Liu Q, Li Z, Yu J
International endodontic journal 2023 Oct;56(10):1284-1300
International endodontic journal 2023 Oct;56(10):1284-1300
Paroxetine protects against bleomycin-induced pulmonary fibrosis by blocking GRK2/Smad3 pathway.
Zhao K, Nie H, Tang Z, Chen G, Huang J
Aging 2023 Oct 9;15(19):10524-10539
Aging 2023 Oct 9;15(19):10524-10539
Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3.
Huang Z, Shen S, Wang M, Li W, Wu G, Huang W, Luo W, Liang G
EMBO reports 2023 Mar 6;24(3):e56135
EMBO reports 2023 Mar 6;24(3):e56135
Possible mechanisms associated with immune escape and apoptosis on anti-hepatocellular carcinoma effect of Mu Ji Fang granules.
Zhang YB, Bao YR, Wang S, Li TJ, Tai H, Leng JP, Yang XX, Wang BC, Meng XS
World journal of gastrointestinal oncology 2023 Mar 15;15(3):504-522
World journal of gastrointestinal oncology 2023 Mar 15;15(3):504-522
Benzylisoquinoline alkaloids inhibit lung fibroblast activation mainly via inhibiting TGF-β1/Smads and ERK1/2 pathway proteins.
Ren HL, Zhang JH, Xiao JH
Heliyon 2023 Jun;9(6):e16849
Heliyon 2023 Jun;9(6):e16849
Resveratrol plays an anti-fibrotic and anti-autophagy role by stimulating miR-192-5p expression in urethral fibrosis.
Lv J, Zhang R, Li D, Liu Y
Functional & integrative genomics 2023 Jul 14;23(3):241
Functional & integrative genomics 2023 Jul 14;23(3):241
BMP4/SMAD8 signaling pathway regulated granular cell proliferation to promote follicle development in Wanxi white goose.
Wei C, Chen X, Peng J, Yu S, Chang P, Jin K, Geng Z
Poultry science 2023 Jan;102(1):102282
Poultry science 2023 Jan;102(1):102282
Trigonelline inhibits tubular epithelial-mesenchymal transformation in diabetic kidney disease via targeting Smad7.
Gong M, Guo Y, Dong H, Wu W, Wu F, Lu F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115747
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115747
Profibrotic role of transcription factor SP1 in cross-talk between fibroblasts and M2 macrophages.
Feng P, Che Y, Gao C, Chu X, Li Z, Li L, Li J, Gao J, Dong Y
iScience 2023 Dec 15;26(12):108484
iScience 2023 Dec 15;26(12):108484
Cell Cycle-Related FAM64A Could be Activated by TGF-β Signaling to Promote Glioma Progression.
Fu M, Zhang J, Zhang L, Feng Y, Fang X, Zhang J, Wen W, Hua W, Mao Y
Cellular and molecular neurobiology 2023 Aug;43(6):2975-2987
Cellular and molecular neurobiology 2023 Aug;43(6):2975-2987
USP25 inhibits renal fibrosis by regulating TGFβ-SMAD signaling pathway in Ang II-induced hypertensive mice.
Zhao Y, Chen X, Lin Y, Li Z, Su X, Fan S, Chen Y, Wang X, Liang G
Biochimica et biophysica acta. Molecular basis of disease 2023 Aug;1869(6):166713
Biochimica et biophysica acta. Molecular basis of disease 2023 Aug;1869(6):166713
SUMOylation of SMAD4 by PIAS1 in Conjunction with Vimentin Upregulation Promotes Migration Potential in Non-Small Cell Lung Cancer.
Wu C, Zhu X, Dai Q, Chu Z, Yang S, Dong Z
Frontiers in bioscience (Landmark edition) 2023 Aug 31;28(8):192
Frontiers in bioscience (Landmark edition) 2023 Aug 31;28(8):192
Qianjin Wenwu decoction suppresses renal interstitial fibrosis by enhancing the degradation of extracellular matrix in mice with unilateral ureteral obstruction.
Jin C, Wu X, You Y, Wang Y, Wu J, Zuo A, Zheng Y, Guo J
Chinese journal of natural medicines 2023 Apr;21(4):253-262
Chinese journal of natural medicines 2023 Apr;21(4):253-262
Smad7 Is Highly Expressed in Human Degenerative Discs and Participates in IL-1β-Induced Apoptosis of Rat AF Cells via the Mitochondria Pathway.
Li B, Lu ZY, Jiang SD, Jiang LS, Zheng XF
Oxidative medicine and cellular longevity 2022;2022:2912276
Oxidative medicine and cellular longevity 2022;2022:2912276
Bu-Gu-Sheng-Sui decoction promotes osteogenesis via activating the ERK/Smad signaling pathways.
Liu N, Qi B, Zhang Y, Fang S, Sun C, Li Q, Wei X
Frontiers in pharmacology 2022;13:976121
Frontiers in pharmacology 2022;13:976121
Post-translational control of beige fat biogenesis by PRDM16 stabilization.
Wang Q, Li H, Tajima K, Verkerke ARP, Taxin ZH, Hou Z, Cole JB, Li F, Wong J, Abe I, Pradhan RN, Yamamuro T, Yoneshiro T, Hirschhorn JN, Kajimura S
Nature 2022 Sep;609(7925):151-158
Nature 2022 Sep;609(7925):151-158
TRIM47 promotes glioma angiogenesis by suppressing Smad4.
Wang Z, Li Z, Han C, Cheng Y, Wang K
In vitro cellular & developmental biology. Animal 2022 Oct;58(9):771-779
In vitro cellular & developmental biology. Animal 2022 Oct;58(9):771-779
Apigenin inhibits fibrous scar formation after acute spinal cord injury through TGFβ/SMADs signaling pathway.
Jin Z, Tian L, Zhang Y, Zhang X, Kang J, Dong H, Huang N, Pan L, Ning B
CNS neuroscience & therapeutics 2022 Nov;28(11):1883-1894
CNS neuroscience & therapeutics 2022 Nov;28(11):1883-1894
SMAD4 Inhibits Granulosa Cell Apoptosis via the miR-183-96-182 Cluster and FoxO1 Axis.
Yao W, Wang S, Du X, Lin C, Zhang J, Pan Z, Li Q
Reproductive sciences (Thousand Oaks, Calif.) 2022 May;29(5):1577-1585
Reproductive sciences (Thousand Oaks, Calif.) 2022 May;29(5):1577-1585
Nicotinamide N-methyltransferase ameliorates renal fibrosis by its metabolite 1-methylnicotinamide inhibiting the TGF-β1/Smad3 pathway.
Zhang W, Rong G, Gu J, Fan C, Guo T, Jiang T, Deng W, Xie J, Su Z, Yu Q, Mai J, Zheng R, Chen X, Tang X, Zhang J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Mar;36(3):e22084
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Mar;36(3):e22084
Gli(ko) BMSC: A potential strategy of treatment for renal fibrosis.
Shi L, Gao X, Bi Y, Li M, Sun H, Tian X, Bi W
Regenerative therapy 2022 Jun;20:157-164
Regenerative therapy 2022 Jun;20:157-164
Multi-material basis and multi-mechanisms of the Dahuang Zhechong pill for regulating Treg/Th1 balance in hepatocellular carcinoma.
Wu L, Yang FR, Xing ML, Lu SF, Chen HL, Yang QW, Zhang YT, Lu Y, Huang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154055
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154055
The Photoperiod Regulates Granulosa Cell Apoptosis through the FSH-Nodal/ALK7 Signaling Pathway in Phodopus sungorus.
Qi Y, Xue HL, Zheng YJ, Yin YF, Xu WL, Xu JH, Wu M, Chen L, Xu LX
Animals : an open access journal from MDPI 2022 Dec 16;12(24)
Animals : an open access journal from MDPI 2022 Dec 16;12(24)
Agmatinase facilitates the tumorigenesis of pancreatic adenocarcinoma through the TGFβ/Smad pathway.
Zhang Y, Cao L, Xie Y, Wang C, Liu X, Zhang X, Chen J
Experimental and therapeutic medicine 2022 Aug;24(2):490
Experimental and therapeutic medicine 2022 Aug;24(2):490
Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy.
Sun X, Yang Y, Sun X, Meng H, Hao W, Yin J, Ma F, Guo X, Du L, Sun L, Wu H
Journal of agricultural and food chemistry 2022 Aug 17;70(32):9865-9876
Journal of agricultural and food chemistry 2022 Aug 17;70(32):9865-9876
Systematic Survey of the Regulatory Networks of the Long Noncoding RNA BANCR in Cervical Cancer Cells.
Wang B, Wang M, Jia S, Li T, Yang M, Ge F
Journal of proteome research 2022 Apr 1;21(4):1137-1152
Journal of proteome research 2022 Apr 1;21(4):1137-1152
The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells.
Zhang Z, Chen B, Zhu Y, Zhang T, Zhang X, Yuan Y, Xu Y
Frontiers in cell and developmental biology 2021;9:664375
Frontiers in cell and developmental biology 2021;9:664375
Pilose Antler Peptide-3.2KD Ameliorates Adriamycin-Induced Myocardial Injury Through TGF-β/SMAD Signaling Pathway.
Xu Y, Qu X, Zhou J, Lv G, Han D, Liu J, Liu Y, Chen Y, Qu P, Huang X
Frontiers in cardiovascular medicine 2021;8:659643
Frontiers in cardiovascular medicine 2021;8:659643
FOXM1-induced miR-552 expression contributes to pancreatic cancer progression by targeting multiple tumor suppressor genes.
Wang X, Dou N, Wang J, Zhang Y, Li Y, Gao Y
International journal of biological sciences 2021;17(4):915-925
International journal of biological sciences 2021;17(4):915-925
Huangqi Shengmai Yin Ameliorates Myocardial Fibrosis by Activating Sirtuin3 and Inhibiting TGF-β/Smad Pathway.
Pan J, Cao Z, Fang C, Lei Y, Sun J, Huang X, Han D
Frontiers in pharmacology 2021;12:722530
Frontiers in pharmacology 2021;12:722530
Hsa_circ_0001021 regulates intestinal epithelial barrier function via sponging miR-224-5p in ulcerative colitis.
Li B, Li Y, Li L, Yu Y, Gu X, Liu C, Long X, Yu Y, Zuo X
Epigenomics 2021 Sep;13(17):1385-1401
Epigenomics 2021 Sep;13(17):1385-1401
SMAD4 Feedback Activates the Canonical TGF-β Family Signaling Pathways.
Liu L, Li Q, Yang L, Li Q, Du X
International journal of molecular sciences 2021 Sep 16;22(18)
International journal of molecular sciences 2021 Sep 16;22(18)
Smad4 deficiency substitutes Cdkn2b but not Cdkn2a downregulation in pancreatic cancer following induction of genetic events in adult mice.
Jia X, Sun B, Tu Q, Qi H, Li L, Liu X, Yan L, Dai H, Kong Q, Tang C, Zhao X
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2021 Mar;21(2):418-427
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2021 Mar;21(2):418-427
MiR-664-3p suppresses osteoblast differentiation and impairs bone formation via targeting Smad4 and Osterix.
Xu Y, Jin Y, Hong F, Ma Y, Yang J, Tang Y, Zhu Z, Wu J, Bao Q, Li L, Yao B, Li D, Ma C
Journal of cellular and molecular medicine 2021 Jun;25(11):5025-5037
Journal of cellular and molecular medicine 2021 Jun;25(11):5025-5037
A mesenchymal-like subpopulation in non-neuroendocrine SCLC contributes to metastasis.
Jin Y, Xiao T, Feng Y, Yang J, Guo C, Hu L, Ji H
Journal of genetics and genomics = Yi chuan xue bao 2021 Jul 20;48(7):571-581
Journal of genetics and genomics = Yi chuan xue bao 2021 Jul 20;48(7):571-581
SEPHS1 promotes SMAD2/3/4 expression and hepatocellular carcinoma cells invasion.
Yang S, Zhang H, Yang H, Zhang J, Wang J, Luo T, Jiang Y, Hua H
Experimental hematology & oncology 2021 Feb 23;10(1):17
Experimental hematology & oncology 2021 Feb 23;10(1):17
Comparison of anticarcinogenic properties of Viburnum opulus and its active compound p-coumaric acid on human colorectal carcinoma.
Karakurt S, AbuŞoĞlu G, Arituluk ZC
Turkish journal of biology = Turk biyoloji dergisi 2020;44(5):252-263
Turkish journal of biology = Turk biyoloji dergisi 2020;44(5):252-263
Novel Alternatively Spliced Variants of Smad4 Expressed in TGF-β-Induced EMT Regulating Proliferation and Migration of A549 Cells.
Wan R, Xu X, Ma L, Chen Y, Tang L, Feng J
OncoTargets and therapy 2020;13:2203-2213
OncoTargets and therapy 2020;13:2203-2213
Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1.
Yang Y, Wang Y, He Z, Liu Y, Chen C, Wang Y, Wang DW, Wang H
Frontiers in pharmacology 2020;11:1136
Frontiers in pharmacology 2020;11:1136
Deubiquitinase USP13 promotes extracellular matrix expression by stabilizing Smad4 in lung fibroblast cells.
Liao X, Li Y, Liu J, Zhang Y, Tan J, Kass DJ, Rojas M, Mallampalli RK, Zhao J, Zhao Y
Translational research : the journal of laboratory and clinical medicine 2020 Sep;223:15-24
Translational research : the journal of laboratory and clinical medicine 2020 Sep;223:15-24
KDM6A suppresses hepatocellular carcinoma cell proliferation by negatively regulating the TGF-β/SMAD signaling pathway.
Li Y, Yang J, Zhang X, Liu H, Guo J
Experimental and therapeutic medicine 2020 Sep;20(3):2774-2782
Experimental and therapeutic medicine 2020 Sep;20(3):2774-2782
Schisandrin B regulates MC3T3-E1 subclone 14 cells proliferation and differentiation through BMP2-SMADs-RUNX2-SP7 signaling axis.
Wang X, Liao X, Zhang Y, Wei L, Pang Y
Scientific reports 2020 Sep 2;10(1):14476
Scientific reports 2020 Sep 2;10(1):14476
Small airway remodeling in diabetic and smoking chronic obstructive pulmonary disease patients.
Wu N, Wu Z, Sun J, Yan M, Wang B, Du X, Liu Y
Aging 2020 May 5;12(9):7927-7944
Aging 2020 May 5;12(9):7927-7944
Co-transplantation with adipose-derived cells to improve parathyroid transplantation in a mice model.
Cui Q, Zhang D, Kong D, Tang J, Liao X, Yang Q, Ren J, Gong Y, Wu G
Stem cell research & therapy 2020 May 26;11(1):200
Stem cell research & therapy 2020 May 26;11(1):200
Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-β1 pathway and interfering with MMP-TIMPs expression.
Su C, Wang Q, Luo H, Jiao W, Tang J, Li L, Tian L, Chen X, Liu B, Yu X, Li S, Guo S, Wang W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110132
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110132
Promotion effects of mono-2-ethyhexyl phthalate (MEHP) on migration and invasion of human melanoma cells via activation of TGF-β signals.
Fan P, Li Z, Zuo C, Fang M
Cell biochemistry and function 2020 Jan;38(1):38-46
Cell biochemistry and function 2020 Jan;38(1):38-46
Transactivation of miR-202-5p by Steroidogenic Factor 1 (SF1) Induces Apoptosis in Goat Granulosa Cells by Targeting TGFβR2.
Ding Q, Jin M, Wang Y, Liu J, Kalds P, Wang Y, Yang Y, Wang X, Chen Y
Cells 2020 Feb 14;9(2)
Cells 2020 Feb 14;9(2)
β2-microglobulin as a biomarker of pulmonary fibrosis development in COPD patients.
Wu Z, Yan M, Zhang M, Wu N, Ma G, Wang B, Fan Y, Du X, Ding C, Liu Y
Aging 2020 Dec 21;13(1):1251-1263
Aging 2020 Dec 21;13(1):1251-1263
Exosome-mediated Hic-5 regulates proliferation and apoptosis of osteosarcoma via Wnt/β-catenin signal pathway.
Sha L, Ma D, Chen C
Aging 2020 Dec 13;12(23):23598-23608
Aging 2020 Dec 13;12(23):23598-23608
Overexpression of matrix metalloproteinase-9 in breast cancer cell lines remarkably increases the cell malignancy largely via activation of transforming growth factor beta/SMAD signalling.
Dong H, Diao H, Zhao Y, Xu H, Pei S, Gao J, Wang J, Hussain T, Zhao D, Zhou X, Lin D
Cell proliferation 2019 Sep;52(5):e12633
Cell proliferation 2019 Sep;52(5):e12633
Oviductus Ranae protein hydrolyzate prevents menopausal osteoporosis by regulating TGFβ/BMP2 signaling.
Li X, Sui X, Yang Q, Li Y, Li N, Shi X, Han D, Li Y, Huang X, Yu P, Qu X
Archives of gynecology and obstetrics 2019 Mar;299(3):873-882
Archives of gynecology and obstetrics 2019 Mar;299(3):873-882
The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis.
Xue K, Zhang J, Li C, Li J, Wang C, Zhang Q, Chen X, Yu X, Sun L, Yu X
Journal of cellular and molecular medicine 2019 Jun;23(6):4229-4243
Journal of cellular and molecular medicine 2019 Jun;23(6):4229-4243
miR-93-5p targets Smad7 to regulate the transforming growth factor-β1/Smad3 pathway and mediate fibrosis in drug-resistant prolactinoma.
Hu B, Mao Z, Du Q, Jiang X, Wang Z, Xiao Z, Zhu D, Wang X, Zhu Y, Wang H
Brain research bulletin 2019 Jul;149:21-31
Brain research bulletin 2019 Jul;149:21-31
Myostatin/SMAD4 signaling-mediated regulation of miR-124-3p represses glucocorticoid receptor expression and inhibits adipocyte differentiation.
Liu K, Zhang X, Wei W, Liu X, Tian Y, Han H, Zhang L, Wu W, Chen J
American journal of physiology. Endocrinology and metabolism 2019 Apr 1;316(4):E635-E645
American journal of physiology. Endocrinology and metabolism 2019 Apr 1;316(4):E635-E645
Inhibition of Skp1-Cullin-F-box complexes during bovine oocyte maturation and preimplantation development leads to delayed development of embryos†.
Kinterova V, Kanka J, Petruskova V, Toralova T
Biology of reproduction 2019 Apr 1;100(4):896-906
Biology of reproduction 2019 Apr 1;100(4):896-906
Transcription coactivator Cited1 acts as an inducer of trophoblast-like state from mouse embryonic stem cells through the activation of BMP signaling.
Xu Y, Luo X, Fang Z, Zheng X, Zeng Y, Zhu C, Gu J, Tang F, Hu Y, Hu G, Jin Y, Li H
Cell death & disease 2018 Sep 11;9(9):924
Cell death & disease 2018 Sep 11;9(9):924
Inhibition of lysyl oxidase expression by dextran sulfate affects invasion and migration of gastric cancer cells.
Xu Y, Wang X, Huang Y, Ma Y, Jin X, Wang H, Wang J
International journal of molecular medicine 2018 Nov;42(5):2737-2749
International journal of molecular medicine 2018 Nov;42(5):2737-2749
Role of TGF-β1/Smad3-mediated fibrosis in drug resistance mechanism of prolactinoma.
Hu B, Mao Z, Jiang X, He D, Wang Z, Wang X, Zhu Y, Wang H
Brain research 2018 Nov 1;1698:204-212
Brain research 2018 Nov 1;1698:204-212
MicroRNA-140 Inhibits the Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.
Li J, Zou K, Yu L, Zhao W, Lu Y, Mao J, Wang B, Wang L, Fan S, Song B, Li L
Molecular therapy. Nucleic acids 2018 Mar 2;10:426-437
Molecular therapy. Nucleic acids 2018 Mar 2;10:426-437
SIRT7 suppresses the epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis by promoting SMAD4 deacetylation.
Li W, Zhu D, Qin S
Journal of experimental & clinical cancer research : CR 2018 Jul 13;37(1):148
Journal of experimental & clinical cancer research : CR 2018 Jul 13;37(1):148
Inhibiting transforming growth factor-β signaling regulates in vitro maintenance and differentiation of bovine bone marrow mesenchymal stem cells.
Zhao XX, An XL, Zhu XC, Jiang Y, Zhai YH, Zhang S, Cai NN, Tang B, Li ZY, Zhang XM
Journal of experimental zoology. Part B, Molecular and developmental evolution 2018 Dec;330(8):406-416
Journal of experimental zoology. Part B, Molecular and developmental evolution 2018 Dec;330(8):406-416
Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients.
Deng WL, Gao ML, Lei XL, Lv JN, Zhao H, He KW, Xia XX, Li LY, Chen YC, Li YP, Pan D, Xue T, Jin ZB
Stem cell reports 2018 Apr 10;10(4):1267-1281
Stem cell reports 2018 Apr 10;10(4):1267-1281
TGFβ1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer.
Zhuang J, Shen L, Yang L, Huang X, Lu Q, Cui Y, Zheng X, Zhao X, Zhang D, Huang R, Guo H, Yan J
Theranostics 2017;7(12):3053-3067
Theranostics 2017;7(12):3053-3067
Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGFβ2 feedback loop.
Lei K, Liang X, Gao Y, Xu B, Xu Y, Li Y, Tao Y, Shi W, Liu J
Biochemical and biophysical research communications 2017 Mar 11;484(3):514-521
Biochemical and biophysical research communications 2017 Mar 11;484(3):514-521
Decrease of FSTL1-BMP4-Smad signaling predicts poor prognosis in lung adenocarcinoma but not in squamous cell carcinoma.
Chiou J, Su CY, Jan YH, Yang CJ, Huang MS, Yu YL, Hsiao M
Scientific reports 2017 Aug 29;7(1):9830
Scientific reports 2017 Aug 29;7(1):9830
Prognostic Value of SMAD4 in Pancreatic Cancer: A Meta-Analysis.
Shugang X, Hongfa Y, Jianpeng L, Xu Z, Jingqi F, Xiangxiang L, Wei L
Translational oncology 2016 Feb;9(1):1-7
Translational oncology 2016 Feb;9(1):1-7
Let‑7a suppresses cell proliferation via the TGF‑β/SMAD signaling pathway in cervical cancer.
Wu T, Chen X, Peng R, Liu H, Yin P, Peng H, Zhou Y, Sun Y, Wen L, Yi H, Li A, Zhang Z
Oncology reports 2016 Dec;36(6):3275-3282
Oncology reports 2016 Dec;36(6):3275-3282
Anti-fibrotic effects of neferine on carbon tetrachloride-induced hepatic fibrosis in mice.
Chen MS, Zhang JH, Wang JL, Gao L, Chen XX, Xiao JH
The American journal of Chinese medicine 2015;43(2):231-40
The American journal of Chinese medicine 2015;43(2):231-40
Biomarkers of TGF-β signaling pathway and prognosis of pancreatic cancer.
Javle M, Li Y, Tan D, Dong X, Chang P, Kar S, Li D
PloS one 2014;9(1):e85942
PloS one 2014;9(1):e85942
Aberrant elevated microRNA-146a in dendritic cells (DC) induced by human pancreatic cancer cell line BxPC-3-conditioned medium inhibits DC maturation and activation.
Du J, Wang J, Tan G, Cai Z, Zhang L, Tang B, Wang Z
Medical oncology (Northwood, London, England) 2012 Dec;29(4):2814-23
Medical oncology (Northwood, London, England) 2012 Dec;29(4):2814-23
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 10231-1-AP(SMAD4 antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SMAD4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SMAD4. This antibody recognizes human, mouse antigen. The SMAD4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
