BS60896

antibody from Bioworld Technology, Inc
Targeting: IL2RA CD25, IDDM10, IL2R
Provider product page for BS60896

Antibody data

Product number
BS60896 - Provider product page
Provider
Bioworld Technology, Inc
Product name
IL2RA polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human IL2RA.
Description
The IL-2 receptor is amulticomponentcomplexconsisting of three subunits,Ï«, ÉÇ and ÎÛ, each ofwhich isrequired for high-affinity binding of IL-2. TheÏ«chain functions primarilyin binding IL-2, whereasthe ÉÇ and ÎÛ chainscontribute to IL-2 binding and are essential to IL-2-induced activation ofsignaling pathways leading to T cell growth. Both IL-4R and IL-7R were initially described as single chain, high-affinityligand-binding cytokine receptors. However, it is now well established that the IL-2RÎÛ chain functions as a second subunit of the high affinityIL-4R and IL-7R receptors. Consequently, the originally described subunits of these latter receptors are nowreferred to asIL-4RÏ«and IL-7RÏ«, respectively,while the common subunit isreferred to as ÎÛc. Although the common ÎÛ chain enhancesligand binding in these three cytokine receptors, it has no capacityto bind these ligands on its own. There is evidence that the ÎÛcchain is also a subunit of IL-13R.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
IL2RA protein structure - BS60896 shown in red.