Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- BS60896 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- IL2RA polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human IL2RA.
- Description
- The IL-2 receptor is amulticomponentcomplexconsisting of three subunits,Ï«, ÉÇ and ÎÛ, each ofwhich isrequired for high-affinity binding of IL-2. TheÏ«chain functions primarilyin binding IL-2, whereasthe ÉÇ and ÎÛ chainscontribute to IL-2 binding and are essential to IL-2-induced activation ofsignaling pathways leading to T cell growth. Both IL-4R and IL-7R were initially described as single chain, high-affinityligand-binding cytokine receptors. However, it is now well established that the IL-2RÎÛ chain functions as a second subunit of the high affinityIL-4R and IL-7R receptors. Consequently, the originally described subunits of these latter receptors are nowreferred to asIL-4RÏ«and IL-7RÏ«, respectively,while the common subunit isreferred to as ÎÛc. Although the common ÎÛ chain enhancesligand binding in these three cytokine receptors, it has no capacityto bind these ligands on its own. There is evidence that the ÎÛcchain is also a subunit of IL-13R.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
No comments: Submit comment
Supportive validation
- Submitted by
- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of IL2RA pAb at 1:500 dilutionLane1:Thp-1 whole cell lysateLane2:H9C2 whole cell lysateLane3:Raw264.7 whole cell lysate