10-4125

antibody from ABEOMICS Inc.

Targeting: IL2RA CD25, IDDM10, IL2R

Antibody data

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Validation data

Product number: 10-4125 - Provider product page
Provider: ABEOMICS Inc.
Product name: Anti-Human CD25 Antibody
Antibody type: Monoclonal
Description: CD25 is the alpha chain of the IL-2 receptor. It is a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2. Though CD25 has been shown to influence effector function of lymphocytes, it is thought to play a greater role in immune tolerance in mice. Constitutive expression of CD25 on Treg cells is thought to be crucial to their survival and maintenance of immune homeostasis. Expression of CD25 and its role in immunology may be species dependent, since CD25 appears to play a larger role in T-cell effector responses in humans compared to mice, and may be somewhat dispensable for the maintenance of Treg cells as seen in patients treated with CD25-blocking antibodies.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Antigen sequence: Recombinant human CD25 protein was used as an imunogen for this antido dy.
Isotype: IgG
Antibody clone number: 7G7B6
Vial size: 100 µg
Concentration: 0.5 mg/ml
Storage: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing

IL2RA protein structure - 10-4125 shown in red.