AGTO-G063S

antibody from Creative Biolabs

Targeting: TNFRSF9 4-1BB, CD137, ILA

Functional assay (Recommended by provider)

Antibody Data

Product number

AGTO-G063S

Provider

Creative Biolabs

Product name

Anti-TNFRSF9 immunotoxin (scFv)-Sap

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-TNFRSF9 scFv to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to the cell surface TNFRSF9 and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of graft-versus-host diseas (GVHD) and the relapse of leukemia.

Reactivity

Human

Host

Mouse