11989-1-AP

antibody from Proteintech Group

Targeting: BSG CD147, EMMPRIN, EMPRIN, OK

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

11989-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#11989-1-AP, RRID:AB_2290597

Product name

CD147 antibody

Antibody type

Polyclonal

Description

CD147 antibody (Cat. #11989-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Functional rescue of a disease-linked ERAD pathway mutation via alternative splicing.

Wang HH, Wang Z, Lin LL, Verma SK, Gniadzik W, Wang H, Li ZJ, Whitestone E, Jiang L, Kuyumcu-Martinez MN, Sun S, Qi L
The EMBO journal 2026 May;45(9):3230-3251

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Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex.

Lin LL, Maldosevic E, Zhou LE, Jomaa A, Qi L
Nature communications 2026 Jan 27;17(1)

---

Evaluating Basigin as a Potential Biomarker of Blood-Brain Barrier Dysfunction in Cerebral Amyloid Angiopathy.

Stellingwerf A, Bosveld D, Jäkel L, De Kort AM, Küsters B, Klijn CJM, Schreuder FHBM, Kuiperij HB, Verbeek MM
Neuropathology and applied neurobiology 2026 Feb;52(1):e70064

---

CD147 mediates the adsorption of influenza A virus on the cell surface through direct interaction with HA.

Wang T, Cao L, Zhang Y, Cheng C, Mao H, Hu X, Sun X, Huang K, Jin M
Frontiers in cellular and infection microbiology 2025;15:1647283

---

Fyn inhibition by TAE684: A synergistic strategy to suppress melanoma and reverse vemurafenib resistance.

Liu W, Zhang X, Liang X, Guo Y, Zhou Z, Zhu S, Peng C, Chen X
Cell death & disease 2025 Nov 6;16(1):796

---

TanGIBLE: A selective probe for evaluating hydrophobicity-exposed defective proteins in live cells.

Iwasa Y, Miyata S, Tomita T, Yokota N, Miyauchi M, Mori R, Matsushita S, Suzuki R, Saeki Y, Kawahara H
The Journal of cell biology 2025 Mar 3;224(3)

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CD147 inhibition reduced fibronectin expression in TGF-β1-induced keloid fibroblasts by targeting Smad2 signaling pathway.

Diao JS, Du HC, Wu J, Han XN, Wu ML, Lai RG, Rahman MA, Shu MG
Burns : journal of the International Society for Burn Injuries 2025 Jun;51(5):107472

---

The ER-associated degradation adaptor SEL1L is dispensable for ER homeostasis and the differentiation of spermatogenic cells.

Tushi NJ, Zhang Z, Sun S
The Journal of biological chemistry 2025 Jul;301(7):110283

---

CD44 cross-linking promotes Plasmodium falciparum invasion.

Kongsomboonvech AK, Scally SW, Le Guen Y, Valissery P, Salinas ND, Cowman AF, Tolia NH, Egan ES
bioRxiv : the preprint server for biology 2025 Jul 30;

---

Structural insights into the human HRD1 ubiquitin ligase complex.

Guo L, Liu G, He J, Jia X, He Y, Wang Z, Qian H
Nature communications 2025 Jul 1;16(1):6007

---

CD44 cross-linking promotes Plasmodium falciparum invasion.

Kongsomboonvech AK, Scally SW, Le Guen Y, Valissery P, Salinas ND, Cowman AF, Tolia NH, Egan ES
Nature communications 2025 Dec 7;17(1):319

---

A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma.

Li J, Ma C, Cao P, Guo W, Wang P, Yang Y, Ding B, Yin F, Li Z, Wang Y, Li S, Huang C, Wang X, Zhou T, Chang A, Zhao L, Gao S, Zhao T, Wang H, Yu J, Xu J, Feng Y, Hao J
Cell reports. Medicine 2025 Aug 19;6(8):102292

---

Requirements for nuclear GRP78 transcriptional regulatory activities and interaction with nuclear GRP94.

Liu Z, Ha DP, Lin LL, Qi L, Lee AS
The Journal of biological chemistry 2025 Apr;301(4):108369

---

Cytoskeletal β-tubulin and cysteine cathepsin L deregulation by SARS-CoV-2 spike protein interaction with the neuronal model cell line SH-SY5Y.

Oliveira BR, Nehlmeier I, Kempf AM, Venugopalan V, Rehders M, Ceniza MEP, Cavalcanti PATPV, Hoffmann M, Pöhlmann S, Brix K
Biochimie 2024 Nov;226:49-61

---

Alarmin S100A8 imparts chemoresistance of esophageal cancer by reprogramming cancer-associated fibroblasts.

Chen X, Cheng G, Zhu L, Liu T, Yang X, Liu R, Ou Z, Zhang S, Tan W, Lin D, Wu C
Cell reports. Medicine 2024 Jun 18;5(6):101576

---

Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high-purity human blood extracellular vesicles.

Hu L, Zheng X, Zhou M, Wang J, Tong L, Dong M, Xu T, Li Z
Journal of extracellular vesicles 2024 Jul;13(7):e12470

---

Intervention with extracellular matrix metalloproteinase inducer in osteoclasts attenuates periodontitis-induced bone resorption.

Wang Y, Zhang L, Zhang L, Li J, Sheng Z, Du Y, Zuo Z, Yu X
Odontology 2024 Jan;112(1):148-157

---

Biallelic Cys141Tyr variant of SEL1L is associated with neurodevelopmental disorders, agammaglobulinemia, and premature death.

Weis D, Lin LL, Wang HH, Li ZJ, Kusikova K, Ciznar P, Wolf HM, Leiss-Piller A, Wang Z, Wei X, Weis S, Skalicka K, Hrckova G, Danisovic L, Soltysova A, Yang TT, Feichtinger RG, Mayr JA, Qi L
The Journal of clinical investigation 2024 Jan 16;134(2)

---

Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders.

Wang HH, Lin LL, Li ZJ, Wei X, Askander O, Cappuccio G, Hashem MO, Hubert L, Munnich A, Alqahtani M, Pang Q, Burmeister M, Lu Y, Poirier K, Besmond C, Sun S, Brunetti-Pierri N, Alkuraya FS, Qi L
The Journal of clinical investigation 2024 Jan 16;134(2)

---

(124)I-labeled anti-CD147 antibody for noninvasive detection of CD147-positive pan-cancers: construction and preclinical studies.

Ma XK, Liu TL, Ren YN, Ma XP, Yao Y, Hou XG, Ding J, Wang F, Huang HF, Zhu H, Yang Z
Acta pharmacologica Sinica 2024 Feb;45(2):436-448

---

Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover.

Podolsky MJ, Kheyfets B, Pandey M, Beigh AH, Yang CD, Lizama CO, Datta R, Lin LL, Wang Z, Wolters PJ, McManus MT, Qi L, Atabai K
Nature communications 2024 Feb 20;15(1):1531

---

SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex.

Lin LL, Wang HH, Pederson B, Wei X, Torres M, Lu Y, Li ZJ, Liu X, Mao H, Wang H, Zhou LE, Zhao Z, Sun S, Qi L
Nature communications 2024 Feb 16;15(1):1440

---

Optimization of protocols for immunohistochemical assessment of enteric nervous system in formalin fixed human tissue.

Hong SM, Qian X, Deshpande V, Kulkarni S
bioRxiv : the preprint server for biology 2024 Dec 17;

---

The mechanism of extracellular CypB promotes glioblastoma adaptation to glutamine deprivation microenvironment.

Yin H, Liu Y, Dong Q, Wang H, Yan Y, Wang X, Wan X, Yuan G, Pan Y
Cancer letters 2024 Aug 10;597:216862

---

Erythrocyte invasion-neutralising antibodies prevent Plasmodium falciparum RH5 from binding to basigin-containing membrane protein complexes.

Jamwal A, Constantin CF, Hirschi S, Henrich S, Bildl W, Fakler B, Draper SJ, Schulte U, Higgins MK
eLife 2023 Oct 5;12

---

SLC16a6, mTORC1, and Autophagy Regulate Ketone Body Excretion in the Intestinal Cells.

Uebanso T, Fukui M, Naito C, Shimohata T, Mawatari K, Takahashi A
Biology 2023 Nov 26;12(12)

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Large-Scale Single-Cell and Bulk Sequencing Analyses Reveal the Prognostic Value and Immune Aspects of CD147 in Pan-Cancer.

Zhang J, Wang Z, Zhang X, Dai Z, Zhi-Peng W, Yu J, Peng Y, Wu W, Zhang N, Luo P, Zhang J, Liu Z, Feng S, Zhang H, Cheng Q
Frontiers in immunology 2022;13:810471

---

Lactate Activates AMPK Remodeling of the Cellular Metabolic Profile and Promotes the Proliferation and Differentiation of C2C12 Myoblasts.

Zhou Y, Liu X, Huang C, Lin D
International journal of molecular sciences 2022 Nov 13;23(22)

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Novel long non-coding RNA CYB561-5 promotes aerobic glycolysis and tumorigenesis by interacting with basigin in non-small cell lung cancer.

Li L, Li Z, Qu J, Wei X, Suo F, Xu J, Liu X, Chen C, Zheng S
Journal of cellular and molecular medicine 2022 Mar;26(5):1402-1412

---

Heat shock protein A12A activates migration of hepatocellular carcinoma cells in a monocarboxylate transporter 4-dependent manner.

Min X, Cheng H, Cao X, Chen Z, Zhang X, Li Y, Mao Q, Xue B, Fang L, Liu L, Ding Z
Cell stress & chaperones 2022 Jan;27(1):83-95

---

Serum Exosomal mir-340-5p Promotes Angiogenesis in Brain Microvascular Endothelial Cells During Oxygen-Glucose Deprivation.

Xu C, Yu H, Chen B, Ma Y, Lv P
Neurochemical research 2022 Apr;47(4):907-920

---

Interaction of CD147 and human epididymis protein 4 promotes invasion and metastasis of ovarian cancer.

Gao L, Nie X, Gou R, Qi Y, Liu J, Lin B
Journal of Cancer 2021;12(24):7422-7435

---

CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGFβ.

Chen R, Wang K, Feng Z, Zhang MY, Wu J, Geng JJ, Chen ZN
Cellular & molecular immunology 2021 Jan;18(1):171-181

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Resveratrol-induced apoptosis is associated with regulating the miR-492/CD147 pathway in malignant melanoma cells.

Zhao S, Tang L, Chen W, Su J, Li F, Chen X, Wu L
Naunyn-Schmiedeberg's archives of pharmacology 2021 Apr;394(4):797-807

---

LncRNA RHPN1-AS1 accelerates proliferation, migration, and invasion via regulating miR-485-5p/BSG axis in hepatocellular carcinoma.

Zhang W, Han L, Xing P, Liu B, Sun Z, Zhou W, Dong J
Naunyn-Schmiedeberg's archives of pharmacology 2020 Dec;393(12):2543-2551

---

α2,6-Sialylation promotes immune escape in hepatocarcinoma cells by regulating T cell functions and CD147/MMP signaling.

Wang L, Li S, Yu X, Han Y, Wu Y, Wang S, Chen X, Zhang J, Wang S
Journal of physiology and biochemistry 2019 Jun;75(2):199-207

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Effects of excess thromboxane A2 on placental development and nutrient transporters in a Mus musculus model of fetal growth restriction.

Gibbins KJ, Gibson-Corley KN, Brown AS, Wieben M, Law RC, Fung CM
Biology of reproduction 2018 May 1;98(5):695-704

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Changes in Corticotrope Gene Expression Upon Increased Expression of Peptidylglycine α-Amidating Monooxygenase.

Mains RE, Blaby-Haas C, Rheaume BA, Eipper BA
Endocrinology 2018 Jul 1;159(7):2621-2639

---

Enterovirus 71 protease 2Apro and 3Cpro differentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms, and enterovirus 71 hijacks ERAD component p97 to promote its replication.

Wang T, Wang B, Huang H, Zhang C, Zhu Y, Pei B, Cheng C, Sun L, Wang J, Jin Q, Zhao Z
PLoS pathogens 2017 Oct;13(10):e1006674

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CD147 promotes IKK/IκB/NF-κB pathway to resist TNF-induced apoptosis in rheumatoid arthritis synovial fibroblasts.

Zhai Y, Wu B, Li J, Yao XY, Zhu P, Chen ZN
Journal of molecular medicine (Berlin, Germany) 2016 Jan;94(1):71-82

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Triptolide inhibits the migration and invasion of human prostate cancer cells via Caveolin-1/CD147/MMPs pathway.

Yuan S, Wang L, Chen X, Fan B, Yuan Q, Zhang H, Yang D, Wang S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Dec;84:1776-1782

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The fucosylated CD147 enhances the autophagy in epithelial ovarian cancer cells.

Hu Z, Cai M, Deng L, Zhu L, Gao J, Tan M, Liu J, Lin B
Oncotarget 2016 Dec 13;7(50):82921-82932

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Inhibition of STAT3 reduces proliferation and invasion in salivary gland adenoid cystic carcinoma.

Bu LL, Deng WW, Huang CF, Liu B, Zhang WF, Sun ZJ
American journal of cancer research 2015;5(5):1751-61

---

C4.4A as a biomarker of head and neck squamous cell carcinoma and correlated with epithelial mesenchymal transition.

Liu JF, Mao L, Bu LL, Ma SR, Huang CF, Zhang WF, Sun ZJ
American journal of cancer research 2015;5(12):3505-15

---

Association Study between an SNP in CD147 and Its Expression With Acute Coronary Syndrome in a Jiangsu Chinese Population.

Yan J, Mao Y, Wang C, Wang Z
Medicine 2015 Oct;94(42):e1537

---

FGF2 as a potential prognostic biomarker for proneural glioma patients.

Sooman L, Freyhult E, Jaiswal A, Navani S, Edqvist PH, Pontén F, Tchougounova E, Smits A, Elsir T, Gullbo J, Lennartsson J, Bergqvist M, Ekman S
Acta oncologica (Stockholm, Sweden) 2015 Mar;54(3):385-94

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A chimeric antibody targeting CD147 inhibits hepatocellular carcinoma cell motility via FAK-PI3K-Akt-Girdin signaling pathway.

Wang Y, Yuan L, Yang XM, Wei D, Wang B, Sun XX, Feng F, Nan G, Wang Y, Chen ZN, Bian H
Clinical & experimental metastasis 2015 Jan;32(1):39-53

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Clinical significance of Keap1 and Nrf2 in oral squamous cell carcinoma.

Huang CF, Zhang L, Ma SR, Zhao ZL, Wang WM, He KF, Zhao YF, Zhang WF, Liu B, Sun ZJ
PloS one 2013;8(12):e83479

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Association of increased ligand cyclophilin A and receptor CD147 with hypoxia, angiogenesis, metastasis and prognosis of tongue squamous cell carcinoma.

Huang C, Sun Z, Sun Y, Chen X, Zhu X, Fan C, Liu B, Zhao Y, Zhang W
Histopathology 2012 Apr;60(5):793-803

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

human liver tissue were subjected to SDS PAGE followed by western blot with 11989-1-AP(CD147 antibody) at dilution of 1:500

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The CD147 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CD147. This antibody recognizes human antigen. The CD147 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

11989-1-AP.pdf

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