Antibody data

Product number
17-1629-42 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD162 (PSGL-1) Monoclonal Antibody (FLEG), APC, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: This FLEG monoclonal antibody recognizes human CD162, which is also known as P-selectin glyocoprotein ligand-1 (PSGL-1). This 120-kDa protein exists as a homodimer on the surface of monocytes, neutrophils, granulocytes, peripheral T cells, some B cells, and a subset of CD34+ hematopoietic progenitor cells (HPCs) in the bone marrow. CD162 binds CD62P (P-selectin), CD62E (E-selectin), and CD62L (L-selectin) to mediate leukocyte interactions with each other as well as with activated platelets and endothelium. Thus, CD162 plays a critical role in leukocyte adhesion and rolling. Furthermore, the binding of CD162 to P-selectin on HPCs has been demonstrated to inhibit hematopoiesis. Studies have also demonstrated CD162 as the receptor for enterovirus 71.
Antibody clone number
FLEG
Concentration
5 µL/Test
SELPLG protein structure - 17-1629-42 shown in red.