12-1509-42

antibody from Invitrogen Antibodies

Targeting: SLAMF1 CD150, SLAM

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

12-1509-42

Provider

Invitrogen Antibodies

Product name

CD150 Monoclonal Antibody (A12 (7D4)), PE, eBioscience™

Antibody type

Monoclonal

Antigen

Other

Description

Description: The A12 monoclonal antibody reacts with human CD150, an ~70 kDa transmembrane glycoprotein also known as Signaling Lymphocyte Activation Molecule (SLAM). CD150 is expressed by T and B cells and its expression is rapidly upregulated on these cells upon activation. Immature thymocytes and dendritic cells also express this antigen. Signaling through SLAM induces proliferation and cytokine production of T cells and SLAM plays a role in activation of T and B cells.

Conjugate

Yellow dye

Antibody clone number

A12 (7D4)

Concentration

5 µL/Test

References

Submitted references

Depletion of regulatory T cells in a mouse experimental glioma model through anti-CD25 treatment results in the infiltration of non-immunosuppressive myeloid cells in the brain.

Maes W, Verschuere T, Van Hoylandt A, Boon L, Van Gool S
Clinical & developmental immunology 2013;2013:952469

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In vivo induction of type 1-like regulatory T cells using genetically modified B cells confers long-term IL-10-dependent antigen-specific unresponsiveness.

Ahangarani RR, Janssens W, VanderElst L, Carlier V, VandenDriessche T, Chuah M, Weynand B, Vanoirbeek JA, Jacquemin M, Saint-Remy JM
Journal of immunology (Baltimore, Md. : 1950) 2009 Dec 15;183(12):8232-43

Flow cytometry

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Staining of normal human peripheral blood cells with Mouse IgG1 K Isotype Control PE (Product # 12-4714-81) (open histogram) or Anti-Human CD150 PE (filled histogram). Cells in the lymphocyte gate were used for analysis.

Conjugate

Yellow dye