BS7320

antibody from Bioworld Technology, Inc
Targeting: TNNC1 TNNC
Provider product page for BS7320
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS7320 - Provider product page
Provider
Bioworld Technology, Inc
Product name
TNNC1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human TNNC1.
Description
Troponin, working in conjunction with tropomyosin, functions as a molecular switch, regulating muscle contraction in response to changes in the intracellular Ca2+ concentration. Troponin consists of three subunits: the Ca2+-binding subunit troponin C (TnC), the tropomyosin-binding subunit troponin T (TnT), and the inhibitory subunit troponin I (TnI) (1). In response to ÉÇ-adrenergic stimulation of the heart, Ser23 and Ser24 of TnI (cardiac) are phosphorylated by PKA and PKC. This phosphorylation stimulates a conformational change of the regulatory domain of TnC, reduces the association between TnI and TnC, and decreases myofilament Ca2+ sensitivity by reducing the Ca2+ binding affinity of TnC (1-3).
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
TNNC1 protein structure - BS7320 shown in red.