Antibody data
- Antibody Data
- Antigen structure
- References [42]
- Comments [0]
- Validations [0]
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- Product number
- 66261-1-Ig - Provider product page

- Provider
- Proteintech Group
- Product name
- PAI-1 antibody
- Antibody type
- Monoclonal
- Description
- PAI-1 antibody (Cat. #66261-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, pig, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1H4A5
- Vial size
- 20ul, 150ul
Submitted references Inhibition of PD-L1 in tubular epithelial cells attenuates renal fibrosis by suppressing TGFβR1 and FZD6 signaling.
Clematis tangutica extract alleviates hyperlipidemia: an integration of network pharmacology, molecular docking, molecular dynamics and experimental verification.
Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF-β1.
Extracellular vesicles derived from senescent hepatocytes drive pan-cancer metastasis in aging.
Shenyuan granules improve cellular senescence through Klotho-mediated p16/p21 signaling pathway in diabetic kidney disease.
LPAR1 Promotes Activation of Pathways Alveolar Hypercoagulation and Fibrinolytic Inhibition in ARDS via NF-κB Signaling Pathway.
Targeting MGLL: terazosin regulates glycerolipid metabolism to mitigate endothelial cell senescence.
Single-cell and spatial RNA sequencing identify divergent microenvironments and progression signatures in early- versus late-onset prostate cancer.
Herbal-based Xuebijing injection ameliorated vascular endothelial dysfunction via inhibiting ACLY/MYB/RIG-I axis in sepsis-associated lung injury.
Quercetin ameliorates ox-LDL-induced cellular senescence of aortic endothelial cells and macrophages by p16/p21, p53/SERPINE1, and AMPK/mTOR pathways.
GP73-dependent regulation of exosome biogenesis promotes colorectal cancer liver metastasis.
Plasminogen Activator Inhibitor 1 Controls Abdominal Aortic Aneurism Formation via the Modulation of TGF-β/Smad2/3 Signaling in Mice.
Restoration of NOX4 signalling reverses endothelial colony-forming cell angiogenic dysfunction associated with experimental and clinical diabetes.
A Sandwiched Patch for Prevention of Pelvic Adhesion After Uterine Operation.
Prognostic Significance and Therapeutic Potential of SERPINE1 in Head and Neck Squamous Cell Carcinoma.
Panaxadiol Attenuates Neuronal Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury via Regulation of the JAK3/STAT3/HIF-1α Signaling Pathway.
1,8-Cineole ameliorates vascular endothelial senescence in diabetes mellitus by directly targeting and deubiquitinating PPAR-γ in vivo and in vitro.
Intratumoral Collinsella aerofaciens exhibits antitumor activity in endometrial carcinoma through activation of the p53 signaling pathway.
Antifibrotic effects of specific targeting of the 5-hydroxytryptamine 2B receptor (5-HT(2B)R) in murine models and ex vivo models of scleroderma skin.
Cerium Oxide Nanoparticles Achieve Long-Lasting Senescence Inhibition in an Aging Mouse Model of Sarcopenia via Reactive Oxygen Species Scavenging and CILP2 Downregulation.
High expression of SERPINE1 and CTSL in keratinocytes in pressure injury caused by ischemia-reperfusion injury.
A spatially resolved transcriptome landscape during thyroid cancer progression.
Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway.
Protective effect of Huashi Baidu formula against AKI and active ingredients that target SphK1 and PAI-1.
Nonswellable Hydrogel Patch with Tissue-Mimetic Mechanical Characteristics Remodeling In Vivo Microenvironment for Effective Adhesion Prevention.
Immunological characterization of stroke-heart syndrome and identification of inflammatory therapeutic targets.
An anti-inflammatory chondroitin sulfate-poly(lactic-co-glycolic acid) composite electrospinning membrane for postoperative abdominal adhesion prevention.
Hypoxia-induced ROS aggravate tumor progression through HIF-1α-SERPINE1 signaling in glioblastoma.
A Cellular Senescence-Related Signature Predicts Cervical Cancer Patient Outcome and Immunotherapy Sensitivity.
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
Novel silk protein/hyaluronic acid hydrogel loaded with azithromycin as an immunomodulatory barrier to prevent postoperative adhesions.
A Cellular Senescence-Related Signature Predicts Cervical Cancer Patient Outcome and Immunotherapy Sensitivity.
Protective Effect of Shenfu Injection on Vascular Endothelial Damage in a Porcine Model of Hemorrhagic Shock.
Human umbilical cord mesenchymal stem cell-derived exosomal microRNA-148a-3p inhibits neointimal hyperplasia by targeting Serpine1.
Bioinformatics analysis of laryngeal squamous cell carcinoma: seeking key candidate genes and pathways.
Weighted correlation network analysis identifies FN1, COL1A1 and SERPINE1 associated with the progression and prognosis of gastric cancer.
ZMPSTE24 Regulates SARS-CoV-2 Spike Protein-enhanced Expression of Endothelial PAI-1.
Identification of Impacted Pathways and Transcriptomic Markers as Potential Mediators of Pulmonary Fibrosis in Transgenic Mice Expressing Human IGFBP5.
Apremilast prevents IL‑17‑induced cellular senescence in ATDC5 chondrocytes mediated by SIRT1.
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability.
E4 engages uPAR and enolase-1 and activates urokinase to exert antifibrotic effects.
Rhamnocitrin extracted from Nervilia fordii inhibited vascular endothelial activation via miR-185/STIM-1/SOCE/NFATc3.
Ahui S, Xufei X, Wangshu W, Bingru Z, Minzhou W, Jiayue L, Wenkai H, Kewei X, Leyi G
International immunopharmacology 2026 Jun 15;179:116621
International immunopharmacology 2026 Jun 15;179:116621
Clematis tangutica extract alleviates hyperlipidemia: an integration of network pharmacology, molecular docking, molecular dynamics and experimental verification.
Zhang X, Ren Q, Guo X, Chen Y, Sun S, Wang M, Ren X, Liu C, Zhang M
Journal of ethnopharmacology 2026 Jun 12;364:121473
Journal of ethnopharmacology 2026 Jun 12;364:121473
Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF-β1.
Peng L, Zhang L, Fan Y, Huang S, Zhao Q, Han C, Hao Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(9):e05256
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(9):e05256
Extracellular vesicles derived from senescent hepatocytes drive pan-cancer metastasis in aging.
Li H, Zhao R, Wan L, Yuan Y, Ma E, Li Y, Chen Z, Liu B, Song Y, Cao Z, Jiao X, Wang Y, Wu P, Jin H, Li J, Yang X, Huang L, Zhang Y, Yang K, Huo J, Jin H, Zhong H, Min M, Zhang S, Cao Y, Li W, Zhang R, Wei C
Nature aging 2026 Apr 6;
Nature aging 2026 Apr 6;
Shenyuan granules improve cellular senescence through Klotho-mediated p16/p21 signaling pathway in diabetic kidney disease.
Guo X, Zhang S, Sun Q, Li H, Wang L
Frontiers in medicine 2025;12:1627412
Frontiers in medicine 2025;12:1627412
LPAR1 Promotes Activation of Pathways Alveolar Hypercoagulation and Fibrinolytic Inhibition in ARDS via NF-κB Signaling Pathway.
Liu Y, Chen X, Liu M, Yuan J, Li Q, Li L, Dong Q, Tao J, Shen F, Xiao C
FASEB bioAdvances 2025 Oct;7(10):e70050
FASEB bioAdvances 2025 Oct;7(10):e70050
Targeting MGLL: terazosin regulates glycerolipid metabolism to mitigate endothelial cell senescence.
Huang J, Yan J, Wan Z, Ji T, Li H, Liang W, Huang Y, Yang Z, Xiao Y, Nie H, Zhang C
Journal of lipid research 2025 Nov;66(11):100904
Journal of lipid research 2025 Nov;66(11):100904
Single-cell and spatial RNA sequencing identify divergent microenvironments and progression signatures in early- versus late-onset prostate cancer.
Cheng Y, Liu B, Xin J, Wu X, Li W, Shang J, Wu J, Zhang Z, Xu B, Du M, Cheng G, Wang M
Nature aging 2025 May;5(5):909-928
Nature aging 2025 May;5(5):909-928
Herbal-based Xuebijing injection ameliorated vascular endothelial dysfunction via inhibiting ACLY/MYB/RIG-I axis in sepsis-associated lung injury.
Cui J, Deng Y, Li X, Gao L, Li J, Li Z, Qu H, Chu Y, Gu Y, Meng M, Li R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156573
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156573
Quercetin ameliorates ox-LDL-induced cellular senescence of aortic endothelial cells and macrophages by p16/p21, p53/SERPINE1, and AMPK/mTOR pathways.
Liang X, Zhang J, Yu J, Zhao J, Yang S
European journal of medical research 2025 May 3;30(1):359
European journal of medical research 2025 May 3;30(1):359
GP73-dependent regulation of exosome biogenesis promotes colorectal cancer liver metastasis.
Huang L, Wei M, Li H, Yu M, Wan L, Zhao R, Gao Q, Sun L, Hou X, Mo Y, Huang Q, Zhen L, Yang X, Li J, Wang N, Zhang C, Jin H, Zhou L, Xu Y, Lin H, Zhang X, Li B, Han Y, Yuan J, Zhang R, Wu F, Zhong H, Wei C
Molecular cancer 2025 May 26;24(1):151
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Plasminogen Activator Inhibitor 1 Controls Abdominal Aortic Aneurism Formation via the Modulation of TGF-β/Smad2/3 Signaling in Mice.
Zhao M, Hu L, Lin Z, Yue X, Zheng X, Piao M, Jin X, Piao L, Cui R, Liu M, Cheng XW
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 15;39(9):e70562
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 15;39(9):e70562
Restoration of NOX4 signalling reverses endothelial colony-forming cell angiogenic dysfunction associated with experimental and clinical diabetes.
O'Neill KM, Edgar KS, Pun SH, Campbell DC, Toh T, Wong XN, Botezatu B, Kandel J, McCoy U, Nicell J, McClintock C, McLoughlin KJ, Wu Y, Madishetti VV, Moez A, Alsaggaf M, Gill EK, Abudalo RA, O'Neill CL, Pedrini E, Guduric-Fuchs J, Brunssen C, Morawietz H, Dunne PD, Watson CJ, Medina RJ, Grieve DJ
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A Sandwiched Patch for Prevention of Pelvic Adhesion After Uterine Operation.
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Prognostic Significance and Therapeutic Potential of SERPINE1 in Head and Neck Squamous Cell Carcinoma.
Zhu C, Liu H, Li Z, Shi Y, Zhao J, Bai Y, Chen Q, Li W
Cancer medicine 2025 Jan;14(2):e70605
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Panaxadiol Attenuates Neuronal Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury via Regulation of the JAK3/STAT3/HIF-1α Signaling Pathway.
Zhou J, Lei Y, Zhang S, Liu Y, Yi D
CNS neuroscience & therapeutics 2025 Feb;31(2):e70233
CNS neuroscience & therapeutics 2025 Feb;31(2):e70233
1,8-Cineole ameliorates vascular endothelial senescence in diabetes mellitus by directly targeting and deubiquitinating PPAR-γ in vivo and in vitro.
Fu L, Tai S, Liao J, Du Y, Zhang G, Guo D, Chen X, Zheng T, Hu X, Yao W, Tao L, Wang X, Xu Y, Shen X
Journal of pharmaceutical analysis 2025 Dec;15(12):101307
Journal of pharmaceutical analysis 2025 Dec;15(12):101307
Intratumoral Collinsella aerofaciens exhibits antitumor activity in endometrial carcinoma through activation of the p53 signaling pathway.
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Journal of translational medicine 2025 Dec 8;24(1):54
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Antifibrotic effects of specific targeting of the 5-hydroxytryptamine 2B receptor (5-HT(2B)R) in murine models and ex vivo models of scleroderma skin.
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Cerium Oxide Nanoparticles Achieve Long-Lasting Senescence Inhibition in an Aging Mouse Model of Sarcopenia via Reactive Oxygen Species Scavenging and CILP2 Downregulation.
Lien WC, Yu YL, Liang YJ, Wang CY, Lin YC, Chang HC, Lin FH, David Wang HM
Small science 2025 Aug;5(8):2500208
Small science 2025 Aug;5(8):2500208
High expression of SERPINE1 and CTSL in keratinocytes in pressure injury caused by ischemia-reperfusion injury.
Bi L, Liu Y, Zhang L, Zhang X, Wang D
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Tissue & cell 2025 Apr;93:102746
A spatially resolved transcriptome landscape during thyroid cancer progression.
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Cell reports. Medicine 2025 Apr 15;6(4):102043
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Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway.
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Protective effect of Huashi Baidu formula against AKI and active ingredients that target SphK1 and PAI-1.
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Chinese medicine 2024 Nov 1;19(1):152
Chinese medicine 2024 Nov 1;19(1):152
Nonswellable Hydrogel Patch with Tissue-Mimetic Mechanical Characteristics Remodeling In Vivo Microenvironment for Effective Adhesion Prevention.
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ACS nano 2024 Jul 9;18(27):17651-17671
Immunological characterization of stroke-heart syndrome and identification of inflammatory therapeutic targets.
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Frontiers in immunology 2023;14:1227104
Frontiers in immunology 2023;14:1227104
An anti-inflammatory chondroitin sulfate-poly(lactic-co-glycolic acid) composite electrospinning membrane for postoperative abdominal adhesion prevention.
Gao R, Li F, Zhang Y, Kong P, Gao Y, Wang J, Liu X, Li S, Jiang L, Zhang J, Zhang C, Feng Z, Huang P, Wang W
Biomaterials science 2023 Sep 26;11(19):6573-6586
Biomaterials science 2023 Sep 26;11(19):6573-6586
Hypoxia-induced ROS aggravate tumor progression through HIF-1α-SERPINE1 signaling in glioblastoma.
Zhang L, Cao Y, Guo X, Wang X, Han X, Kanwore K, Hong X, Zhou H, Gao D
Journal of Zhejiang University. Science. B 2023 Jan 15;24(1):32-49
Journal of Zhejiang University. Science. B 2023 Jan 15;24(1):32-49
A Cellular Senescence-Related Signature Predicts Cervical Cancer Patient Outcome and Immunotherapy Sensitivity.
Shao H, Li X, Wu P, Chen Z, Zhang C, Gu H
Reproductive sciences (Thousand Oaks, Calif.) 2023 Dec;30(12):3661-3676
Reproductive sciences (Thousand Oaks, Calif.) 2023 Dec;30(12):3661-3676
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
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Transplantation and cellular therapy 2023 Aug;29(8):492.e1-492.e10
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Novel silk protein/hyaluronic acid hydrogel loaded with azithromycin as an immunomodulatory barrier to prevent postoperative adhesions.
Tian L, Sun T, Fan M, Lu H, Sun C
International journal of biological macromolecules 2023 Apr 30;235:123811
International journal of biological macromolecules 2023 Apr 30;235:123811
A Cellular Senescence-Related Signature Predicts Cervical Cancer Patient Outcome and Immunotherapy Sensitivity.
Shao H, Li X, Wu P, Chen Z, Zhang C, Gu H
Research square 2023 Apr 20;
Research square 2023 Apr 20;
Protective Effect of Shenfu Injection on Vascular Endothelial Damage in a Porcine Model of Hemorrhagic Shock.
Zhang MQ, Zhang Q, Yuan W, Wu JY, Liang Y, Qin HJ, Li CS
Chinese journal of integrative medicine 2022 Sep;28(9):794-801
Chinese journal of integrative medicine 2022 Sep;28(9):794-801
Human umbilical cord mesenchymal stem cell-derived exosomal microRNA-148a-3p inhibits neointimal hyperplasia by targeting Serpine1.
Zhang X, Zhou Y, Ye Y, Wu R, Li W, Yao C, Wang S
Archives of biochemistry and biophysics 2022 Apr 15;719:109155
Archives of biochemistry and biophysics 2022 Apr 15;719:109155
Bioinformatics analysis of laryngeal squamous cell carcinoma: seeking key candidate genes and pathways.
Ma J, Hu X, Dai B, Wang Q, Wang H
PeerJ 2021;9:e11259
PeerJ 2021;9:e11259
Weighted correlation network analysis identifies FN1, COL1A1 and SERPINE1 associated with the progression and prognosis of gastric cancer.
Zhao Q, Xie J, Xie J, Zhao R, Song C, Wang H, Rong J, Yan L, Song Y, Wang F, Xie Y
Cancer biomarkers : section A of Disease markers 2021;31(1):59-75
Cancer biomarkers : section A of Disease markers 2021;31(1):59-75
ZMPSTE24 Regulates SARS-CoV-2 Spike Protein-enhanced Expression of Endothelial PAI-1.
Han M, Pandey D
American journal of respiratory cell and molecular biology 2021 Sep;65(3):300-308
American journal of respiratory cell and molecular biology 2021 Sep;65(3):300-308
Identification of Impacted Pathways and Transcriptomic Markers as Potential Mediators of Pulmonary Fibrosis in Transgenic Mice Expressing Human IGFBP5.
Nguyen XX, Renaud L, Feghali-Bostwick C
International journal of molecular sciences 2021 Nov 22;22(22)
International journal of molecular sciences 2021 Nov 22;22(22)
Apremilast prevents IL‑17‑induced cellular senescence in ATDC5 chondrocytes mediated by SIRT1.
Wang B, Sun W, Bi K, Li Y, Li F
International journal of molecular medicine 2021 Mar;47(3)
International journal of molecular medicine 2021 Mar;47(3)
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability.
Wu M, Chen W, Miao M, Jin Q, Zhang S, Bai M, Fan J, Zhang Y, Zhang A, Jia Z, Huang S
Clinical science (London, England : 1979) 2021 Jul 30;135(14):1707-1726
Clinical science (London, England : 1979) 2021 Jul 30;135(14):1707-1726
E4 engages uPAR and enolase-1 and activates urokinase to exert antifibrotic effects.
Sharma S, Watanabe T, Nishimoto T, Takihara T, Mlakar L, Nguyen XX, Sanderson M, Su Y, Chambers RA, Feghali-Bostwick C
JCI insight 2021 Dec 22;6(24)
JCI insight 2021 Dec 22;6(24)
Rhamnocitrin extracted from Nervilia fordii inhibited vascular endothelial activation via miR-185/STIM-1/SOCE/NFATc3.
Lin T, Luo W, Li Z, Zhang L, Zheng X, Mai L, Yang W, Guan G, Su Z, Liu P, Li Z, Xie Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Dec;79:153350
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Dec;79:153350
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